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Depending on the primary site there may be a different prognosis and biological characteristics; in fact, an aggressive clinical course and a high rate of systemic relapse after curative resection in the abdominal primary site are observed . When surgical margins are close, especially in high - grade sarcomas, preopera...
In eukaryotes, dna is packaged into a group of histone proteins to form nucleosome, the basic structural unit of chromatin . Dimers of four distinct histone proteins (h2a, h2b, h3, and h4) constitutes the histone octamer that is a structural scaffold for nucleosome . Because dna is tightly packaged in nucleosome and nu...
Cyclophosphamide, doxorubicin, vincristine, and prednisolone (chop) therapy is an effective systemic chemotherapy for non - hodgkin's lymphoma, and chop - based regimens have been widely used . However, most of these drugs cannot cross the blood - brain barrier, and thus they fail to attain effective concentrations in ...
Atherosclerosis is the major cause of cardiovascular morbidity and mortality, with underlying pathological processes that may begin during childhood [1, 2]. Although the exact causes of atherosclerosis are not clear, it is thought to involve lipoprotein influx into the wall, across the endothelium, and chronic inflamma...
In the previous issue of critical care, wittbrodt and colleagues report the results of their long - term follow - up of human subjects from a randomized trial comparing hydroxyethyl starch and ringer's acetate solution . At first glance, the authors' observations appear to be pedestrian and could be misperceived as a t...
However, the egna - neumarkt glaucoma study stated that the burden of pacg in europe has been underestimated previously . The prevalence in this study was 0.6%, which accounts for about a quarter of all primary glaucoma cases . The most frequent type was chronic angle closure, which is more insidious and hence more oft...
Type 2 diabetes mellitus (t2 dm) is a chronic disease arising from both environmental and genetic factors . T2 dm is characterized by disrupted secretory activity in pancreatic -cells, resistance to insulin action in peripheral tissues, or both together . New treatment options for t2 dm are needed because current treat...
This network enabled assessment of serum samples from patients during the early clinical phase of infection . Of these samples, 377 were positive for igg against puuv, of which 330 were positive for igm against puuv by an in - house elisa (11) and immunoblot assay (recomline bunyavirus; mikrogen, neuried, germany). The...
Imaging has an important role to play in the management of breast diseases, which often present as breast mass, breast pain and the likes . Breast imaging has only come of age in the twenteith century, beginning with the introduction of mammography, which stemmed from the discoveries of x - rays and radiation in the la...
The incidence of cutaneous melanoma (cm) continues to increase in the caucasian population in the united states . In 2014, women only accounted for 42% of the 76,100 new melanoma cases and only 33% of the 9,710 deaths associated with cm in the united states . Indeed, gender disparity in melanoma outcome is so consisten...
Parathyroid dysfunction is well known in long duration lithium treatment, though it is less frequent when compared to hypothyroidism . We are reporting a patient who developed hypercalcemia while on treatment with lithium, requiring surgical treatment . A 28-year - old lady reported to the endocrinology department for ...
, actin is a key player in the development of neurons and maintenance of neuronal physiology . In developing neurons, actin provides the structural network for morphogenesis . In adult neurons, actin participates in the formation and dynamics of pre- and postsynaptic structural integrity . Therefore, it is not a surpri...
Gamma - secretase is a key protease activity involved in the production of alzheimer's disease a amyloid peptides and in regulated intramembrane processing of a subset of membrane receptors, including notch (reviewed in). A is proteolytically derived from the type i integral amyloid precursor protein (app) by two seque...
Epilepsy is the most common serious chronic neurological brain disorder afflicting humankind, with no racial, socioeconomic, national, or geographic predilections; it affects more than 50 million people worldwide . The tendency of epilepsy to onset in children renders its socioeconomic impact disproportionate; moreover...
Cells migrate by coordinating cytoskeletal - mediated extensions and contractions concomitantly with making and breaking contacts to an underlying substratum . To orchestrate directional movements, cells must activate a specific site(s) at the membrane periphery in response to a polarized external cue (fig . 1; cortica...
Hyperphosphatemia is a risk factor for secondary hyperparathyroidism, a serious complication that increases the risk of cardiovascular diseases in hemodialysis patients . Lanthanum carbonate (lac), a phosphate binder that does not contain calcium, has been reported to decrease serum phosphorus levels . It has been repo...
Despite the fact that the outcome of patients with systemic lupus erythematosus (sle) has improved considerably over the last decades, neuropshychiatric involvement remains a main cause of morbi - mortality 1, 2, being responsible for up to 19% of deaths in sle 3, 4 . The real prevalence of neuropsychiatric sle (npsle)...
Transurethral resection of the prostate (turp) is considered the standard treatment for men with benign prostatic hyperplasia (bph) (1). However, this procedure is associated with significant morbidity . In order to minimize the perioperative morbidity of turp procedures, various minimally invasive alternatives have be...
Endoscopic treatment of stone disease in children has developed dramatically during the last 2 decades . Since the first pediatric ureteroscopic procedure in 1988, ureterorenoscopy (urs) has become a more attractive option for treating children due to significant improvements in the miniaturization and durability of en...
For decades, endodontically treated teeth with significant coronal tissue loss were restored with cast metal post and core . Despite the high retention rate and thin layer of cement, metal posts have been associated with irreparable root fractures . This is primarily due to the modulus of elasticity of metal being high...
These agents are popular for inpatient and home administration because of the decreased need for laboratory monitoring, resulting in lower costs, and their limited interactions with other medications or foods, new york, ny) are the simplified fixed dosing and the improved safety in patients with severe renal insufficie...
Recent reports have highlighted white adipose tissue (wat) as one of the primary contributors to the chronic low - grade inflammation commonly observed in obesity and related complications (e.g., type 2 diabetes, metabolic syndrome). As wat expands, it has been hypothesized that microhypoxia results in adipocyte stress...
At the first of july 2006, the rohs directive of the european union (directive on the restriction of the use of certain hazardous substances in electrical and electronic equipment 2002/95/ec) has come into force . Due to this directive the use of lead is prohibited in electronic products, however, with a number of exem...
The approach we adopted in our first experiments was to create a cavity in the cerebral cortex which could serve as a culturing chamber where the exposed vessel - rich surface of the underlying choroidal fissue could serve as a source of rapid vascularization . Small pieces of tissue dissected from the fetal brain were...
A 60-year - old woman is presented who required resection of both pulmonary and adrenal metastases from cervical adenocarcinoma . The patient was diagnosed with stage ia adenocarcinoma of the cervix which was treated surgically . Five years later she was diagnosed with recurrent, metastatic cervical adenocarcinoma to b...
Mexican population is estimated to be over 120 million of which 78% lives in urban areas [1, 2]. This implies a significant burden to provide medical care where gdp is nearly $1,300 billion usd and average income per capita is fairly below $10 thousand usd . Yet nearly a fourth of its citizens is deprived of adequate m...
A 38-year - old woman planned to undergo open heart surgery to surgically correct a known severe mr . She had a history of undergoing percutaneous balloon valvuloplasty due to rheumatic mitral stenosis (ms) during a previous pregnancy 10 years before . At the preoperative evaluation employing 2d tte, a tearing of the t...
Phosphorus is necessary for several, various biological roles in the signal transduction of cells and energy exchange of human body . About 80%90% of phosphorus mineral balance is regulated by a complex interaction between gastrointestinal absorption, renal excretion and translocation between parts of the human body . ...
Cancer is the third leading cause of death worldwide, and lung cancer is the second most commonly occurring non - cutaneous cancer with the highest mortality rate among all cancers . There are 1.38 million new cases of lung cancer every year, along with 1.23 million deaths due to lung cancer.1 based on the histological...
Restoration of missing, decayed or mutilated dentition has been one of the foremost responsibilities of dentists the world over . Materials selected for the restoration of teeth should fulfill the basic criteria of strength, biocompatibility and esthetics . In the past, metals were employed widely due to their unsurpas...
We screened stool specimens for sav by using rt - pcr and described the genetic diversity of virus - positive specimens . A total of 95 stool specimens were collected from children <18 years of age treated for gastrointestinal illness at the sydney children's hospital . These specimens were negative for common foodborn...
Psoriasis, a common and enigmatic recurrent cutaneous disease, has for long been considered a hyperproliferation with extremely increased rate of epidermal turnover, and an activated mononuclear infiltrate in the underlyingdermis . Recent progress in the understanding of psoriasis has attributed its pathogenesis to the...
Esophageal varices are the major complication of portal hypertension . It is detected in about 50% of cirrhosis patients, and approximately 515% of cirrhosis patients show newly formed varices or worsening of varices each year [15]. It is a hemodynamic abnormality characterized by sudden bleeding episode; about a third...
Hand disability limits a patient's activities of daily life, leading to reductions in self - sufficiency and deterioration of quality of life . This condition can be caused by injuries, surgery and diseases . Recovering hand function requires pharmacological treatment together with a rehabilitation protocol including t...
The main structures that are known to process pain are the primary and secondary somatosensory, insula, anterior cingulated, and prefrontal cortices, as well as the thalamus (1). Additional structures that play a smaller role are the basal ganglia, cerebellum, amygdala, hippocampus, and areas within the parietal and te...
It is a rather dynamic process of wound healing in response to a variety of persistent liver injury caused by factors such as ethanol intake, chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infection, drugs, toxins, cholestasis, and metabolic disorders . Liver fibrogenesis is a common widespread pathologica...
Multidimensional infrared spectroscopy probes nuclear motions in condensed phase and biomolecular systems through the dynamics associated with vibrational couplings . Maximal interpretation of multidimensional vibrational spectra in terms of molecular structure and dynamical fluctuations relies on simulating observable...
Fluticasone propionatemicroparticles were prepared by the spray - drying method using chitosan, mannitol along with l - leucine . The particle sizes of the microparticles were increased with the increase in the chitosan concentration . As low inlet temperatures of air - drying and feed flow rate are important parameter...
Mucocele is a common salivary gland disorder which is defined as a mucus filling cyst that usually appears in the oral cavity, paranasal sinuses, or lacrimal sac . The term mucocele is derived from a latin word, mucus and cocele meaning cavity . Clinically, mucoceles are of two types (a) extravasation and (b) retention...
The rise in the prevalence of obesity over the past decade has become an increasingly relevant issue because this medical condition is an important risk factor for type 2 diabetes mellitus (t2 dm) and cardiovascular disease (cvd), which may lead to a higher incidence of all - cause mortality . Approximately 30% of obes...
Drilling into mechanisms governing the control of hemoglobin synthesis led to the discovery in the 1980s of a new class of transcription factors containing a highly conserved cys4 dual zinc finger dna - binding module . These proteins were deemed gata factors based on the nucleotide composition of their cognate dna - b...
We can model circulation systems in order to find the parameters of pressure, flow and blood volume . Among the variables that are involved in the value of these parameters, we can point to the dimensions and elasticity of vessels, fluid density at standard conditions and viscosity of vessel . For better analysis of th...
Hypertension is considered the leading risk factor for cardiovascular disease (cvd), with myocardial infarction and stroke accounting for most cases.1 because of its high prevalence, hypertension is responsible for the majority of the cases of cvd.2 however, data from longitudinal cohort studies are subject to confound...
This article is a descriptive analytic research carried out as a case - control study during years 2007 and 2008 in isfahan university of medical sciences, school of medicine . The study included 100 children and adolescents from 5 to 18 years old with type 1 diabetes mellitus referred to the isfahan diabetes research ...
A 12-year - old boy known to have idiopathic he s presented to our ed with a complaint of cough, shortness of breath (sob), and severe chest tightness for the previous 1 h. he had been diagnosed with refractory he s 4 years back, with a course complicated by multiple organ involvement . Previous medications included cy...
Studies have shown that in the 20 century, 80% of scientific productions were related to science and technology (2). Scientific works requires information, and also the essential part of information is derived from previous works (3). The world of education, technology, and research is also faced with increasing comple...
Williams syndrome (omim #194050) is a rare, well - documented, multisystem genetic condition affecting approximately 1/7,500 individuals . There are no marked regional differences in the prevalence of this disease.1) the syndrome is caused by the hemizygous deletion of approximately 28 genes, including eln on chromosom...
In a genome - wide association study of breast cancer conducted among chinese women, we identified a new susceptibility locus for breast cancer, the single nucleotide polymorphism (snp) rs2046210 . Snp rs2046210 is located on chromosome 6q25.1, 29 kb upstream of the first untranslated exon and 180 kb upstream of the tr...
The term proteomics describes the study and characterization of complete set of proteins present in a cell, organ, or organism at a given time . In general, proteomic approaches can be used (a) for proteome profiling, (b) for comparative expression analysis of two or more protein samples, (c) for the localization and i...
One of the major concerned questions in solid organ transplantation is how to establish long - term allograft survival that is free from immunosuppressive strategies . The most promising answer to decades of years have witnessed the attempts to achieve this goal from cotransplantation with hematopoietic stem cell to th...
A 56-year - old male patient presented to our emergency department with chief complains of inability to void urine for 24 hours and vague abdominal pain . He was diagnosed as a case of acute urinary retention and was referred to the surgical team for further management . The surgical junior resident briefly examined hi...
Celiac disease (cd) is an immune - mediated inflammation of the small intestine caused by sensitivity to dietary gluten in genetically sensitive individuals . The disorder is common, occurring in 0.5 to 1 percent of the general population in most countries (1). Overall, the global distribution of the disease seems to p...
Hydroxyapatite (ha; ca10(po4)6(oh)2) is a type of calcium phosphate that has extensive application in the healing of bones and teeth, due to its biocompatibility and similar composition to that of natural bone.15 one of the most common methods for the synthesis of hydroxyapatite and fluorapatite is the sol - gel method...
The current study was performed as part of the maastricht aging study (maas), a longitudinal study of determinants of cognitive aging (12). A total of 10,396 people were sampled from the registration network family practices (rnh), a patient register of collaborating general practitioners in the province of limburg, th...
There is a societal trend towards increased awareness and emphasis on beauty and facial aesthetics . Accordingly, the facial profile is one of the most important factors to consider in orthodontic or orthognathic surgical patients.1 many studies have assessed anterior - posterior relationships of the maxilla and mandib...
The genus cymbopogon belongs to one of the most important essential oil yielding families of the poaceae and comprises nearly 140 species that are widely distributed in semitemperate to tropical regions of asia, africa, and america . Stapf is native from the southwest asia and now it grows spontaneously around the worl...
The study subjects were pregnant women recruited from 2 medical institutions of obstetrics in osaka, japan . All subjects provided written informed consent after the nature and possible consequences of the study had been explained . The study protocol was approved by the ethics committee at the osaka city university gr...
The present classification of phacomatosis pigmentovascularis includes four distinct types, namely, phacomatosis cesioflammea, phacomatosis cesiomarmorata, phacomatosis spilorosea, and phacamatosis melanorosea . An additional group comprises various unclassifiable forms of extensive capillary nevi coexisting with a lar...
Influenza frequently results in the development of acute respiratory infection in children younger than 2 years, with a higher admission rate than that caused by respiratory syncytial virus infection1). During an influenza epidemic, influenza - related morbidity increases significantly in children younger than 1 year, ...
An increasing number of patients are visiting hospitals owing to abnormal posture and idiopathic spinal deformities . Such conditions are especially serious for adolescents, who are undergoing dramatic musculoskeletal growth . This problem appears closely related to lifestyle issues such as learning environment and lac...
Different strategies are available to teach specific topics for surgeons such as courses, cadaver laboratories, and online presentations . However, the learning process is complex, and sometimes the knowledge transfer strategy is not as successful as expected . In an attempt to improve teaching tools, de boer et al dev...
Diabetes is a common chronic condition which requires several complex self - care chores(1). It has been reported that the incidence of type 2 diabetes mellitus (t2 dm) is increasing in both industrialized and developing countries due to behavioral causes and changes in the life style (2). It has been expected that the...
Apurinic / apyrimidinic endonuclease 1/redox factor-1 (ape1/ref-1), also known as apex1, is the mammalian ortholog of escherichia coli xth (exonuclease iii). Oxidative dna lesions, including apurinic / apyrimidinic (ap) sites, have been reported as occuring at an estimated rate of 1.510 residues / cell / day.1 ape1/ref...
In recent years expectations have been raised that stem cell replacement therapy could be used as a therapeutic approach to compensate for lost or damaged neuronal cells and to restore functionality in brain areas affected by chronic neurodegenerative diseases, such as alzheimer disease (ad). The accumulation of amyloi...
Expert reviewing of microscopic data is a well - known procedure in medical practice, within the framework of cooperative studies with therapeutic, epidemiological, or scientific purposes . In the current state of things, this notion, however, mostly remains a theoretical one owing to persisting practical difficulties ...
The advent of the flexible endoscope and its world - wide use in clinical practice has had a major impact on the management of gastric cancer. (1) histopathologic diagnosis remains the foundation of clinical decision making in the treatment of gastric neoplasia . However, based on subjective morphologic criteria, clini...
Bladder cancer is one of the most frequent malignancies around the world (1). In the united states, the estimated number of new cases for 2014 is 69,000 while the estimated number of deaths is approximately 15,000 (2). Evidence suggests that the activation of the telomerase enzyme is a pivotal step in the development o...
The skin, a major site of defense against pathogenic agents, is exposed to a large number of environmental chemicals, some of which induce allergic reactions (sensitizers)., great efforts have been made to identify and quantitatively assess skin sensitizers, in view of the risk of unexpected exposure to identified and ...
Melanocortin-4 receptor (mc4r) is the cognate receptor for -melanocyte stimulating hormone (-msh), a cleavage product of proopiomelanocortin (pomc) which is expressed in hypothalamic arcuate nuclei (arc) neurons (1). Mc4r activation by agonists such as -msh inhibits feeding and causes weight loss (2). Agouti related pe...
Since combination therapy with steroids and cyclophosphamide was first introduced, the prognosis for patients with anti--neutrophil cytoplasmic antibody (anca)-associated vasculitis has improved significantly [1, 2]. However, the effectiveness of this therapy has proved to be limited, and adverse reactions to these med...
A prerecorded message instructed callers to contact their state or local health department if they had not done so . Calls that could be answered with frequently asked questions documents or guidelines published in the morbidity and mortality weekly report (mmwr) were handled directly by public health advisors, epidemi...
Triad has been described in detail elsewhere (2). In 20002001 and 20022003, surveys were administered by computer - assisted telephone interview or in writing by mail . We included participants who had survey and medical record data at both baseline and follow - up (n = 5,478). Characteristics of the study population w...
Despite recent advances in treatment of non - small - cell lung cancer (nsclc), almost all patients with metastatic or unresectable cases of nsclc inevitably experience disease progression . In addition, as supportive care of patients with advanced cancer is developing, an increasing number of patients with advanced ns...
Individuals with cancer commonly experience anorexia, weight loss, and wasting of muscle and adipose tissue [1, 2]. These symptoms are also accompanied by a number of metabolic abnormalities, including alterations in carbohydrate, protein, and lipid metabolism, and insulin resistance [3, 4]. This syndrome, known as cac...
Presbycusis, or age related hearing loss, exerts a substantial socioeconomic impact, affecting over 25% of those 50 years old and over . This loss manifests as progressive high - to - low frequency loss . Clinically, there is difficulty in speech localization and sound discrimination . The cause of presbycusis is still...
However, recent studies showed that the adipose tissue is a highly active endocrine organ, which synthesizes and secretes a large number of proteins, such as leptin, resistin, adiponectin, angiotensinogen, and many others . Some of these proteins induce insulin resistance, others play a role in glucose and lipid metabo...
The discovery by cheresh and coworkers that antagonists specific for v3 or v5 selectively block angiogenesis induced by bfgf and vegf, respectively, provided some of the first support for a role of v integrins in angiogenesis and led them to postulate the existence of two separate angiogenic pathways (friedlander et al...
Although some reports describing the incidence of atrial fibrillation (af) after closure of interatrial septal communications (iasc) have been published, most of them have used a few well - established devices [13]. Some limitations of these studies have been acknowledged, the larger study choosing to omit analyzing at...
Although pterygium excision with conjunctival autograft is a widely performed surgical procedure, surgically induced necrotizing scleritis (sins) following such surgery is extremely rare . On postoperative day 17, the conjunctival graft was avascular, with epithelial defect . Although topical steroid and antibacterial ...
Cat and dog fleas are the most common parasites responsible for flea bite in humans . Cat flea bite results in extreme pruritis which may be prolonged if not identified early . It requires appropriate medical management and eradication of fleas from the environment to achieve treatment success . Cat flea infestation is...
Schizophrenia, with a prevalence of about 1% among the general population, is one of the major mental health problems around the world . The disease develops during childhood and adolescence . In the course of this disorder, the patient experiences recurrent relapses and long - term hospitalization, which lead to consi...
Balance is indispensable to an individual s ability to safely and independently perform activities of daily living such as moving or walking1 . In stroke patients, trunk muscle weakness and the loss of proprioception on the affected side can interfere with balance, stability, and functional ability2, 3 and may reduce t...
Alopecia areata (aa) is an autoimmune disorder cause of inflammation - inducednon - scarring type of hair loss, which consists of 1% patients referred to the dermatology clinic.1 aa due to the complications affects the patients quality of life and reduces their self - esteem.2 the life - time risk of aa is about 2.1% a...
Retinal prostheses are under investigation by several groups [1, 2], and some preclinical and clinical trials have been reported [36]. Preclinical experiments are intended to estimate the stimulation parameters and to evaluate the efficacy and the safety of the devices and the clinical trials are aimed at demonstrating...
In the last decades, deaths from stroke have declined . Despite the decline in mortality, the annual number of cases of stroke is expected to increase within the next few decades, mainly due to a 30% growth in the elderly population . Stroke is a heterogeneous disorder consisting of three major pathological types: isch...
The prevalence and incidence of hypertension, arguably the most important modifiable risk factor for cardiac and cerebrovascular diseases, are going to increase dramatically worldwide over the next decade . Prevention and treatment of high blood pressure (bp) already represent a public health challenge in many areas of...
Osteoblastoma (ob) is a benign tumor of bone characterized by osteoid and bone formation with the presence of numerous osteoblasts . This tumor was first described by jaffe and mayer in 1932 . The current term benign osteoblastoma was proposed by jaffe and lichtenstein in two separate reports in 1956 ., osteoblastoma c...
Smoking causes a variety of disabilities in man . It kills more than five million people a year an average of one person every 6 seconds and is responsible for one in ten adult deaths . More than 80% of the one billion smokers worldwide live in low- and middle - income countries, where the burden of tobacco - related i...
Worldwide reports have revealed that occurrence of such disorders are very low in populations where consanguinity is discouraged (1). However, in pakistan, high rate of consanguinity have resulted in comparative increase in probability of the disease occurrence . Wholly hair loss is generally considered to be associate...
A number of causes for these mutations have been described, including intrinsic mutation processes such as damage from endogenous reactive oxygen species or incomplete fidelity of the dna replication machinery and extrinsic factors such as environmental and lifestyle exposures . For example, uv light and tobacco exposu...
In recent years, aesthetics has become increasingly important: everyone wants to be beautiful, according to modern society's concept of beauty . Since a beautiful smile can make the difference, dental and oral implantology are no exception: patients have high aesthetic expectations of implant - prosthetic treatment and...
One of the main steps of the root canal treatment is to provide the suitable conditions for periapical tissues to heal up by biomechanical instrumentation of the root canal system . During the instrumentation, necrotic debris, residual pulp tissue, microorganisms, dentin chips, or irrigation solutions this situation ma...
Primary data collection, whereby researchers collect information on subjects for purposes of analysis within a study, remains a core and necessary requirement for many clinical research studies, even with the expanded secondary use of electronic health information for research . The costs of collecting and managing res...
Pseudomonas aeruginosa is an oxidase positive, glucose non - fermenting gram negative bacillus that normally inhabits soil and aquatic environments . Its large genome, adaptive regulatory systems, metabolic versatility and high intrinsic antibiotic resistance, facilitates its survival in a diverse range of habitats.p ....
Prostate cancer is the most common malignancy in the united state . In 2009, 192,280 men were estimated to have been diagnosed with prostate cancer, and 27,360 of these patients died in the united states . The prostate - specific antigen (psa) is used for the detection of prostate cancer in daily practice, but its diag...
Modification of otherwise soluble proteins with hydrophobic moieties, such as myristoyl or isoprenyl groups, is essential for their targeting to cell membranes . In contrast, thioester linkage of palmitate, a c16 saturated fatty acid, to cysteine residues (s - palmitoylation) is a reversible modification catalyzed by m...
Thyroid eye disease (ted) is an autoimmune inflammatory disorder involving the orbital tissues . It is the most common extrathyroidal manifestation of graves disease but may also be associated with hashimoto s thyroiditis.13 although its pathogenesis is not completely understood, autoimmune activation of pre - adipocyt...
The application of wireless telemedicine in monitoring patients is seen as a useful and potentially powerful tool to help patients seek medical treatment [1, 2]. In remote monitoring systems of asthmatic patients, cough signals (as well as other body vital signs) are collected by sensors attached to the patient and sen...
In this issue of critical care, dale rublee and colleagues look beyond 28-day all - cause mortality, assessing the effects of antithrombin iii on quality of life in sepsis survivors . Although many of us would like to think that the battle has been won when a patient leaves the intensive care unit (icu) after severe se...