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It is the third most common cancer worldwide and the fourth most common cause of death [2, 3]. Rectal cancer is defined as disease occurring in the distal 1215 cm of the large bowel, where the distal two - thirds is extraperitoneal . Total mesorectal excision (tme) is the standard surgical approach to proctectomy for r... |
Metabolic syndrome (mets), known as insulin resistance syndrome, is characterized by a cluster of cardiovascular risk factors such as hypertension, glucose intolerance, high triglycerides, and low high density lipoprotein - cholesterol (hdl - c) concentrations.1) mets confers an increased risk for vascular disease - as... |
Dynamic time warping (dtw), described in the text of kruskal and liberman (1), is an algorithm to compute the optimal alignment of numerical sequences . Using dynamic programming (2), dtw was first introduced by vintsyuk (3) and applied in speech recognition by sakoe and chiba (4). While most applications of dtw are in... |
In the previous issue of critical care, kollef and colleagues compared 7 days of doripenem with 10 days of imipenem in patients with ventilator - associated pneumonia (vap) caused by gram - negative bacilli (gnb). The 7-day course arm was found to have non - significant higher rates of clinical failure and mortality co... |
Syphilis is a sexually transmitted disease (std) caused by the bacterium treponema pallidum, but little is known about its mechanism of action or what determines virulence of infection . Untreated syphilis in pregnancy leads to adverse outcomes among more than half of the women with active disease, including early feta... |
The prevalence of allergic diseases is continuously increasing . It is estimated that approximately one - third of the general population is affected by allergic diseases . Asthma, food allergy, dermatitis, and systemic anaphylaxis are amongst the most common allergic diseases . The myriad of symptoms observed may invo... |
Sweat gland carcinoma is very rare with a reported incidence of less than 0.005% of all tumour specimens resected surgically . They represent a group of tumours with potential for local tissue infiltration and regional as well as distant metastasis . Due to limited availability of literature, the diagnosis as well as m... |
In order to reduce the challenges of community participation in health research methods, suggested solution is to use community - based participatory research (cbpr). This kind of research aims to promote health or decrease inequality in health by attracting community participation . It is reasonable to believe that cb... |
Emphysematous pyelonephritis (epn) is a condition in which there is gas forming necrotizing infection of the renal parenchyma and perinephric tissue . Workup for other etiological agents should be carried out if patient does nt respond to antibiotic therapy or deteriorates clinically . Fungal etiology has rarely been r... |
They have widespread distribution in the world and have important roles as agricultural pests and spread of infectious diseases . There are many parasites in rodents, which can be transmitted to human and domestic animals (1). Investigation on the role of rodents as reservoirs of parasitic agents is a subject of intere... |
The only studies with physician subjects involve peer - coaching, a model distinct from professional coaching.56,57 a pilot study of four nurses and physical therapists demonstrated improvement in job satisfaction and self- efficacy.58 physician coaching case reports exist, both to improve communication skills23 and fo... |
The hypothalamic - pituitary - gonadal (hpg) axis is finely regulated at a central level by the activity of gnrh neurons, a peculiar hypothalamic neuronal subpopulation, comprising few cells (8002000 cells in the adult brain) scattered within the preoptic area (poa) of the hypothalamus [1, 2]. The anatomical position o... |
As an emerging biomedical imaging technique, photoacoustic imaging (pai) has experienced considerable growth in the past decade . It has been explored for molecular imaging of biomarkers, functional imaging of physiological parameters [3, 4] and the imaging of tumor angiogenesis [57] in both preclinical and clinical st... |
In biological systems, l - lactate (lactate) is usually considered as a waste product of glycolysis . Recent evidence supports that lactate has an independent function in modulating neurotransmission and it serves as an important energy source for neurons.1,2 the brain contains considerable amounts of lactate that can ... |
Retinal redetachment, especially in a silicone oil - filled eye, continues to be among the most frustrating and challenging conditions faced by vitreoretinal surgeons . The recurrence rate of retinal detachment in silicone oil - filled eyes is approximately 20% [14]. The major cause of redetachment in these cases is at... |
Scc arise on sun - exposed areas of the skin and may behave aggressively, resulting in recurrence or metastasis . Many genetic and environmental factors are known to contribute to the development of sccs, the most important being repeated exposures to the ultraviolet (uv) in the sunlight [3, 4]. Epidemiological studies... |
The global world of the 21 century has created communities and cultures that are interconnected, thanks to the development both in the field of transportation and technology . In this global intercultural community, future physicians, and even more so future general practitioners (gps)/family physicians (fps), need to ... |
Chondroblastoma is a rare tumor entity that comprises approximately 1% of all benign bone tumors . In up to 95% cases, it occurs in the second decade of life with a male: female ratio of 2:1 . The most frequent localizations of chondroblastoma are epiphyses of long bones (proximal humerus, proximal femur, distal femur ... |
In the previous issue of critical care, cuthbertson and colleagues capped a long - standing research agenda by reporting long - term mortality and quality of life among survivors of severe sepsis from a scottish cohort . These sepsis - specific data from a large population catchment are a nice complement to the previou... |
Strontium ranelate is a relatively new drug used for the treatment of osteoporosis that both stimulates bone formation and inhibits bone resorption.1,2 randomized, placebo - controlled clinical trials have demonstrated the efficacy of strontium ranelate in reducing the risk of osteoporotic vertebral and nonvertebral fr... |
Non - small cell lung carcinomas are a heterogeneous group of tumors having poor prognosis . Eighty percent of lung cancer cases are at an inoperable advanced stage at the time of diagnosis . A wide range of therapies, including targeted therapy, are being used for treatment . It frequently shows histological heterogen... |
Acute pulmonary embolism (pe) is a common clinical problem, often with fatal consequences . Most cases of pe arise from deep vein thrombosis (dvt) in the calf and about 80% of patients with pe have dvt at the time of presentation (1). Various factors associated with pe such as smoking, immobilization, and malignancy ha... |
New and interesting rna sequences are being rapidly discovered . As a consequence, researchers are becoming increasingly reliant on computer - generated secondary structure predictions as an initial step in elucidating structurefunction relationships . Thermodynamics - based dynamic folding algorithms, such as mfold an... |
Human cysticercosis is caused by infection with the larvae (cysticerci) of taenia solium, a cestode (tapeworm) transmitted among humans and between humans and pigs . Humans acquire tapeworm infection from eating raw or undercooked pork meat containing t. solium cysticerci . When ingested, cysticerci are activated by st... |
Protein tyrosine kinases (tks) play a crucial role in signal transduction pathways regulating numerous cellular functions, including differentiation and proliferation . Chronic myeloid leukemia (cml) is caused by the constitutively up - regulated tk bcr - abl1 resulting from the reciprocal balanced chromosomal transloc... |
Chronic pain represents a relevant medical condition with detrimental effects on life quality and socio - economical state . Patients with chronic pain may not respond positively to standard pharmacological therapies and may require other alternative approaches to relieve symptoms . In 1991, tsubokawa et al . Reported ... |
Paroxysmal nocturnal hemoglobinuria (pnh) is a disease characterized by intra - vascular hemolysis, thrombosis, and bone marrow failure . The disease is associated with mutations in the pig - a gene in hematopoietic stem cells, resulting in a deficiency of glycosylphosphatidylinositol (gpi)-anchored proteins.1 this def... |
Cissus sicyoides (cs) belonging to the vitaceae family comprises of about 165 genus and 1370 species, which are distributed throughout the tropics, mainly in brazil and the caribbean . Insulinas, cipo - puc, bejuco de porra, bejuco caro, puci, and anil trepador . Originally from the dominican republic, it is used in po... |
Healthcare spending is growing at an explosive rate and accordingly cost - containment is a major goal in healthcare at present . Given the heavy financial burden and social expectations, healthcare reform has also become a major economic and political issue . In the midst of this, advanced diagnostic imaging modalitie... |
Data on infants, ages <12 months, hospitalized with a clinical diagnosis of dhf were obtained from four hospitals: children s hospital no . 1, ho chi minh city, vietnam; the queen sirikit national institute of child health, also referred to as bangkok children s hospital, bangkok, thailand; children s hospital, yangon,... |
Recent medical progress has led to an increase in the number of cardiac arrest survivors . According to one estimate, up to 200 people per 1 million inhabitants however, about half of these survivors suffer severe neurological sequelae (brct 1991), because the brain is the organ most vulnerable to hypoxia . Focal neuro... |
Viral culture of the stool of a 6-day - old patient with a 2-day history of high fever and poor feeding and no history of gastrointestinal or respiratory symptoms showed enterovirus cytopathic effects . However, pcr targeted at the 5 untranslated region (utr) of enterovirus (13) was negative, whereas a 5 utr pcr specif... |
Pain is a common symptom in patients with advanced malignant cancer and greatly increases physical and mental suffering . Most of the patients (60%90%) with advanced cancer present different degrees of pain, of which 30% are with unbearable pain symptoms [1, 2]. Surgery, radiotherapy, and chemotherapy have been used as... |
Bardet - biedl syndrome is a continuum of systemic manifestations that include obesity, polydactyly, hypogonadism and mental retardation . The ocular examination can reveal different types and severity of pigmentary retinal dystrophy (including retinitis pigmentosa sine pigmento, retinitis punctate albescens or even ty... |
Chiral sulfides are important for the synthesis of a wide range of biologically relevant molecules and are also versatile synthetic intermediates for a variety of organic transformations . In recent years, a number of methods have been developed for the direct formation of stereogenic carbon centers bearing sulfur . Th... |
Anaemia is common in cancer patients with a reported prevalence of 40% in solid tumours [1, 2]. Overall anaemia in patients presenting with cancer is associated with reduced survival [3, 4] and reduced quality of life [2, 5]. Although anaemia is associated with chronic blood loss from the gastrointestinal tract, malign... |
Fibromyalgia (fms) is a chronic pain syndrome in which pathogenesis is complex and cure is not known . It affects approximately 10 million adults in the united states with an estimated 90% of diagnoses being reported in women . Sequelae of fms include physical and psychological distress, loss of work productivity, redu... |
Cellular responses induced by traumatic central nervous system (cns) injury are associated with both destructive and regenerative processes mediated by neurons, glial and immunogenic cell types, and the endothelial compartment . They are orchestrated by defined changes in gene expression, leading to chronological casca... |
The incidence of type 2 diabetes mellitus (type 2 dm) is increasing at an alarming rate both nationally and worldwide . Defects in pancreatic -cell function, insulin sensitivity, and systemic inflammation all contribute to the development of type 2 dm . Since insulin resistance is a risk factor for diabetes, understand... |
Nesfatin-1 is an 82-amino - acid peptide originated from post translational processing of the n - terminal fragment of nucleobindin 2 (nucb2), a 396-amino - acid protein exceptionally conserved across mammalian species (oh - i et al ., 2006). Post translational cleavage of nucb-2 appears in the expression of nesfatin-2... |
Brucellosis is a zoonosis disease caused by the bacterial genus brucella . That is transmitted directly or indirectly by contact with infected animals or contaminated dairy products . Brucella species are small, gram - negative, nonmotile, nonspore - forming, and rod - shaped (coccobacilli) bacterial organisms and 8 sp... |
Vorapaxar is a firstinclass oral proteaseactivated receptor (par)1 antagonist, which inhibits thrombininduced platelet activation and is effective in the secondary prevention of atherothrombosis . We previously reported the primary results of the thrombin receptor antagonist in secondary prevention of atherothrombotic ... |
As a service to our authors and readers, this journal provides supporting information supplied by the authors . Such materials are peer reviewed and may be reorganized for online delivery, but are not copyedited or typeset . Technical support issues arising from supporting information (other than missing files) should ... |
A 10-year - old japanese girl presented with an 8-month history of pigmented lesion on the sole of the right foot . Examination showed a rhomboid - shaped brown macule with keratotic scale, 4x3 mm in size, on the lateral center side of the sole (figure 1). Dermoscopic examination revealed that a number of black dots an... |
We retrospectively evaluated the clinical records of all the consecutive patients, diagnosed with acute lgi bleeding and who underwent an angiography from january 2003 to october 2007 . We obtained a waiver from the institutional review board for patient consent for this study . In total, we identified 46 patients who ... |
Myotonic dystrophy (md) is a multi - system disorder, the most well known symptoms being muscle weakness and myotonia . Distressing daytime sleepiness and diminished spontaneous activity, often referred to as inertia, reduced initiative, inactivity or apathy, these latter symptoms often seem to cause more hindrance in ... |
Testicular lymphoma is an aggressive extranodal lymphoma that arises primarily in the testis or as a part of generalized nhl . Primary testicular lymphoma (ptl) usually presents as a unilateral testicular mass of variable size and can show contiguous spread to rete testis, epididymis, spermatic cord and rarely to tunic... |
Laser in situ keratomileusis (lasik), originally described in 1990 by pallikaris,1 remains the most commonly performed surgical technique to correct refractive errors . Adequate repositioning of the lasik flap at the end of the procedure with symmetrical gutters circumferentially is essential to attain good postoperati... |
Mferg responses were recorded in 40 subjects with a history of preterm birth (table). All subjects had serial fundus examinations in the newborn intensive care nursery in accordance with the american academy of pediatrics section on ophthalmology guidelines for rop screening . Rop was classified using the international... |
Gold nanoparticles which absorb light strongly in the near - infrared (nir) wavelength region from 700 to 1100 nm, where blood and tissue absorb weakly, are of great utility in biomedical imaging modalities such as photoacoustic imaging . Strong nir extinction is often produced from nanoclusters of closely spaced prima... |
The world that we are living in is constantly changing and survival is based on learning both the reward and the penalty information associated with changing contingencies . During evolution, animals increased their ability to adapt their responses or actions to environmental stimuli depending on trial - to - trial fee... |
An mri of the lumbar spine was then performed, which clearly demonstrated a lesion of the fifth lumbar vertebra, within the confines of the vertebral cortex, having low t1- and high t2-weighted signal intensities, and showing no enhancement (fig . There was no evidence of soft tissue extension . In the presence of only... |
A canine is considered as being impacted if it is interrupted after complete root development or if the contralateral tooth is erupted for at least 6 months with complete root formation . Maxillary canines are one of the most commonly impacted teeth after the third molars with prevalence in the range of 0.82.8% . The i... |
Oral and maxillofacial surgical procedures under general anesthesia have a relatively common complication of postoperative nausea and vomiting (ponv). Postoperative vomiting may predispose patients to increased pain, bleeding, dehydration, electrolyte imbalance, and delayed wound healing1 . There are a number of drugs ... |
The description of macromolecular interactions in terms of the binding constant and gibbs energy of binding is widely used in considering protein protein and protein dna complexes . However, it is far from sufficient for elucidating the nature of the physical forces acting between the partners, in particular for unders... |
Serum samples were obtained from 4 areas in peru: chiclayito and salitral (piura department); la merced (junin department); and cusco (cusco department) (figure). Chiclayito is a small village (population 6,133) 30 m above sea level on the outskirts of the city of piura in the northern coastal desert . Salitral is a sm... |
Squamous cell carcinoma is not uncommon in patients with xeroderma pigmentosum and mostly involving the face, head, neck, and scalp . Here, we present a huge squamous cell carcinoma of the scalp in a three - years - old child with xeroderma pigmentosum . In addition, we illustrate the challenges of a child with xeroder... |
Osteoporosis is the most common bone disease known, affecting an estimated 200 million people worldwide . Approximately 30% of all postmenopausal women are affected and up to 40% will develop a fragility fracture within their lifetime . Over time, a number of risk factors have been associated with osteoporosis and are ... |
Anorectal malignancies are commonly adenocarcinoma or squamous cell carcinoma(1), with melanoma having a relative incidence of 0.5% 4% of all malignancies in this region (13). This site is the third most common primary location for melanoma after the skin and retina and yet only 0.4 - 1.6% of all primary melanomas aris... |
Are generally caused by inadequate production due to suppression of bone marrow by hiv infection through abnormal cytokine expression and alteration of the bone marrow microenvironment . We present a series of bone marrow abnormalities in hiv infected children who presented with anemia . A 7-year - old boy presented wi... |
We aimed to visualize the retinal arterial wall thickness, assisted by noninvasive adaptive optics scanning laser ophthalmoscopy (ao - slo). The arterial wall thickness was measured and compared between one normal subject and one patient suffering from malignant hypertensive retinopathy . Increased arterial wall thickn... |
The use of liver grafts from public health service (phs) increased risk donors (irds), donors at increased risk for transmission of blood - borne diseases, remains inconsistent in liver transplantation . These donors include those who have been recently incarcerated, those who practice intravenous drug abuse or prostit... |
Primary biliary cholangitis (pbc), previously known as primary biliary cirrhosis, is a chronic cholestatic liver disease with an autoimmune basis, affecting mostly middle - aged women.1 the inflammatory response leads to slow destruction of small intrahepatic bile ducts and progression at varying rates to cirrhosis lea... |
When hyperglycemia begins before the age of 6 months and lasts for more than 14 days, it is considered as neonatal diabetes . Overall, neonatal diabetes is categorized into two groups . In half of the cases; i.e., the transient form, the patients hyperglycemia is spontaneously improved . In the other type, the patients... |
Non - coding rnas such as micrornas (mirnas) are now well established as important biological regulators . In particular, mirnas act both to destabilize the transcripts they bind to and to block their translation . This binding event is mediated by a protein complex that recruits the mature mirna to its target transcri... |
Chest wall skeletal defects are usually closed using muscle flaps, other autogenous tissue, or prosthetic materials . However, reconstruction procedures involving typical muscle flaps, such as the pectoralis major, latissimus dorsi, serratus anterior, and rectus abdominis, need additional incisions and plastic surgery ... |
Amflora (eh92 - 527 - 1) is a genetically modified (gm) potato variety, solanum tuberosum l. of the chemical company basf (ludwigshafen, germany). Is composed of two main parts amylose and amylopectin, 20 and 80% respectively . While amylopectin is the required starch component for industrial purposes due to its thicke... |
Graves' disease management guidelines of the japanese thyroid association recommend that methimazole (mmi) should be used in every patient with graves' disease as the first - choice drug except for during the first trimester of pregnancy . However, when patients with graves' disease show an allergic skin reaction to mm... |
We estimated 338 thyroidectomy specimens from the files of the department of pathology, seoul national university hospital and boramae hospital, from 1993 to 2003 . These tissue samples were from patients with adenomatous goiter (ag, n=57), follicular adenoma (fa, n=58), follicular carcinoma (fc, n=57), papillary carci... |
On anterior segment examination, she had iris abnormalities of hypoplasia, corectopia, and sclerocornea prominent at the lateral limbus of both eyes (fig . Cycloplegic retinoscopy was -3.5 diopters (d) in the right eye and -4.0d in the left eye . Ocular alignment revealed 20 prism diopters (pd) of exotropia with 30pd o... |
Laparoscopic cholecystectomy (lc) has become the first - line procedure for most patients with gallstones . Endo - retractors are convenient devices for exposure and traction during minimally invasive surgery and are widely used in lc . Herein we present a patient with diaphragmatic injury caused by an endo - retractor... |
Primary biliary cirrhosis (pbc), primary sclerosing cholangitis (psc), and hepatolithiasis in adults and biliary atresia and choledochal cyst in infants are biliary diseases in which different anatomical levels of the biliary tree are specifically affected and characterized by cholangiopathy . The biliary tree, consist... |
Spinal anaesthesia (sa) is nowadays considered the standard anaesthetic technique for elective caesarean section . However, the chance of hypotension is a major limitation of this technique . The incidence of hypotension is more than 80% without any prophylactic measures . The incidence of hypotension can be lowered by... |
Pulpectomy is intended to remove an irreversibly infected or necrotic pulp of deciduous tooth, meanwhile maintaining the functional state until the permanent teeth take its position . However, the procedure has its own shortcomings which include incomplete instrumentation of complex torturous canals and unavailability ... |
We took both gross dissection and microscopic examination to elucidate whether lateral palpebral raphe existed or not, in which the decision was made by the single examiner (hk). In gross dissection, five eyelids of three caucasian cadavers (2 males: 1 right, 2 left; 1 female: 1 right, 1 left) aged from 81 to 89 years ... |
Striving for excellence motivates you; striving for perfection is demoralizing . Striving for excellence motivates you; striving for perfection is demoralizing . Striving for excellence in any endeavor conscientiously striving to achieve difficult but attainable goals usually leads to feelings of satisfaction . However... |
Citation indexing databases entitle journals to index their citations if the journal s structure coincides with the platform of that database and on condition that the journal contains a valid number of citations . Authors need to present their names in these databases too, in order to gain higher scientific reputation... |
Nonsteroidal anti - inflammatory drugs (nsaids) form the basis of treatment and contraceptive pills are also used in treatment . Nsaids inhibit prostaglandin synthesis, and so, they are important in the treatment of this disease . The effectiveness of these agents has been consistently confirmed, with response rates ex... |
We retrospectively reviewed the medical records of patients with rae who were diagnosed between january 1995 and december 2007 at yeungnam university hospital . Approval to conduct this study was obtained from the institutional review board of yeungnam university hospital . Patients who met the following criteria were ... |
Due to lower birth rates and better healthcare, the average age of the world's population has increased . In korea in particular, rapid increases in life expectancy have been observed over the past few decades, with the life expectancy of females increasing from 79.6 years in 2000 to 85.1 years in 2013 (1). This increa... |
Quantum theory states that, at zero temperature and in the absence of any radiation, there are fluctuations of the electromagnetic field (the so - called vacuum fluctuations) that give rise to the well - known van der waals and casimir forces between polarizable objects . These forces are at the heart of many fluctuati... |
The concept of oral health - related quality of life (ohrqol) relates to the impact which oral health or disease has on the individual's daily functioning, well - being or quality of life (qol). There is current interest in children's qol18,21, which includes social, psychological and functional aspects5, as well as or... |
Neurofibromatosis type 1 (nf1) is a common, progressive, autosomal dominant neurocutaneous disorder characterized by variable expressivity and a predisposition to the development of tumors . Clinical features include caf - au - lait macules, skin - fold freckles, lisch nodules, and dermal neurofibromas . Chronic myeloi... |
Calcium hydroxide (ca(oh)2) as an intracanal medicament (icm) has been extensively studied and its clinical use well established . In aqueous solution ca(oh)2 dissociates into calcium and hydroxyl ions . The large amount of hydroxyl ions liberated interferes with the bacterial cytoplasmic membrane integrity, largely by... |
Urinary incontinence (ui) is a common condition that affects approximately 27% (957%) of women worldwide . It has a negative impact on quality of life, especially in the domains of social, physiological, physical and sexual well - being . Health is understood as a state of full physical, psychological and social well b... |
With an overall incidence of approximately 1 in 50,000 to 1 in 1,00,000 live births, gaucher's disease is the most prevalent lysosomal storage disorder . An autosomal recessive disorder, gaucher's disease is caused by mutations in the glucocerebrosidase gene, leading to decreased enzyme activity and accumulation of glu... |
Extracapillary proliferative cellular lesions or cellular crescents are a hallmark of severe inflammatory reactions in glomeruli and have been documented in various forms of glomerulonephritis (gn). Crescents are observed in various forms of gn including rapidly progressive gn, postinfectious gn, iga nephropathy, purpu... |
Vertigo in migraine patients may be in two forms: either both symptoms (migraine and vertigo) may co - occur in the same patient as different entities or vertigo may be an integral part of migraine . In order to differentiate migraine and vertigo as integral phenomena of a single disorder from simply co - morbid sympto... |
Heart failure (hf) is a common disease in the community setting.1 at the same time, the sensitivity of clinical signs is low and gps have a limited toolbox available to provide a rapid diagnosis.2 assessment of left ventricular (lv) function with echocardiography is mandatory in patients with suspected hf.3 however, mo... |
Cystic echinococcosis (ce) is a zoonotic infection of human and domestic animals caused by the larval stages of the cestode echinococcus granulosus . This helminthic zoonosis is one of the most important diseases for human and livestock in the country (1 - 3). Larvae of e. granulosus produce an antigen, known as antige... |
Hydrocephalus is most commonly treated with shunt insertion (si) and/or endoscopic third ventriculostomy (etv). In spite of the many attempts at comparing the surgery methods in question, there has been no definite answer as to which method of treating hydrocephalus in a population of young children is superior and whi... |
B. monnieri is an important constituent of ayurveda and has been mentioned in haraka samhita, suruta - samhita and other treatise (1). The presence of active saponins like bacosides a and b in bm act as antioxidant and memory enhancer (2). The antioxidant property of bm has been studied against various toxicants includ... |
The dimorphic fungi coccidioides immitis and posadasii are endemic to the southwestern united states as well as parts of mexico and south america . However, in a small percentage of cases coccidioides disseminate widely to the skin, meninges, joints, and bones . We report a case of disseminated coccidioidomycosis in a ... |
Sweating capacity as measured by sweat secretion rates has been reported reduced in adult patients with gh deficiency [14] as well as in children with gh deficiency (ghd) and gh insensitivity syndromes [5, 6]. Furthermore, sweat secretion has been found correlated to circulating igf - i levels [1, 4, 7], and gh deficie... |
Genetic alterations in various genes responsible for the maintenance of the normal epithelial phenotype has come forward as a major cause for the deregulation of normal epithelial physiology however, it is well established that genetic mutations are correlated with various environmental stimuli . In addition, direct ex... |
It has been shown to affect 18% of women and 6.5% of men in united states . Worldwide approximately 240 millions of people have an estimated 1.4 billion attacks of migraine each year . Severe migraine has been included in the list of global burden of diseases by world health organization (who) and it represents a serio... |
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