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COMMENT Conceptual model: D current for a model of a fast-spiking cortical interneuron. Authors and citation: Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007). Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156. Original implementation and program...
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COMMENT ipulse2.mod Generates a train of current pulses User specifies dur (pulse duration), per (period, i.e. interval between pulse onsets), and number of pulses. Ensures that period is longer than pulse duration. 2/6/2002 NTC ENDCOMMENT NEURON { POINT_PROCESS Ipulse2 RANGE del, dur, per, num, amp, ...
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/***************************** TMS simulator for T2N morphologies Main simulation function; call to execute and run according to input parameters AUTHOR: Nicholas Hananeia CONTACT: nickhananeia@gmail.com *******************************/ func TMS_sim(){ localobj detector //*********Load libraries and initialize******...
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TITLE Cortical Muscarinic current COMMENT ----------------------------------------------------------------------------- Muscarinic potassium current ---------------------------- - noninactivating K+ current responsible for the adaptation of firing rate and the afterhyperpolarization (AHP) of cortical pyramid...
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:Reference :Colbert and Pan 2002, from Hay et al., 2011 PLOS Comp Bio, https://doi.org/10.1371/journal.pcbi.1002107 :comment: took the NaTa and shifted both activation/inactivation by 6 mv :Comment : corrected rates using q10 = 2.3, target temperature 37 (K. Duecker for duecker_ET_model, fast L5 ET pyr APs), orginal ...
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:Reference :Colbert and Pan 2002, from Hay et al., 2011 PLOS Comp Bio, https://doi.org/10.1371/journal.pcbi.1002107 :comment: took the NaTa and shifted both activation/inactivation by 6 mv :Comment : corrected rates using q10 = 2.3, target temperature 32 (K. Duecker for duecker_ET_model, slower L2/3 pyr APs), orginal 2...
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TITLE fast activated potassium Kv3 (Kv3.1/3.2) for PV interneurons COMMENT modeled by Gunay et al., 2008 implemented in NEURON by Kitano, 2011 ENDCOMMENT UNITS { (mV) = (millivolt) (mA) = (milliamp) } NEURON { SUFFIX Kv3m USEION k READ ek WRITE ik RANGE gmax, iKv3, ik RANGE theta_m, k_m, tau_m0, tau_m1, phi_...
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TITLE fast activated potassium Kv3 (Kv3.1/3.2) for PV interneurons COMMENT modeled by Gunay et al., 2008 implemented in NEURON by Kitano, 2011 ENDCOMMENT UNITS { (mV) = (millivolt) (mA) = (milliamp) } NEURON { SUFFIX Kv3mixed USEION k READ ek WRITE ik RANGE gmax, iKv3, ik RANGE theta_m, k_m, tau_m0, tau_m1, ...
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TITLE fast activated potassium Kv3 (Kv3.1/3.2) for PV interneurons COMMENT modeled by Gunay et al., 2008 implemented in NEURON by Kitano, 2011 ENDCOMMENT UNITS { (mV) = (millivolt) (mA) = (milliamp) } NEURON { SUFFIX Kv3 USEION k READ ek WRITE ik RANGE gmax, iKv3, ik RANGE theta_m, k_m, tau_m0, tau_m1, phi_m...
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: HH TEA-sensitive Purkinje potassium current : Created 8/5/02 - nwg : Suffix from kpkj to Kv3_4 NEURON { SUFFIX Kv3_4 USEION k READ ek WRITE ik RANGE gkbar, ik RANGE minf, hinf, mtau, htau } UNITS { (mV) = (millivolt) (mA) = (milliamp) } CONSTANT { q10 = 3 } PARAMETER { v (mV) gk...
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:Comment : mtau deduced from text (said to be 6 times faster than for NaTa) :Comment : so I used the equations from NaT and multiplied by 6 :Reference : Modeled according to kinetics derived from Magistretti & Alonso 1999 :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 : **Modified to use '...
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:Comment : mtau deduced from text (said to be 6 times faster than for NaTa) :Comment : so I used the equations from NaT and multiplied by 6 :Reference : Modeled according to kinetics derived from Magistretti & Alonso 1999, from Hay et al., 2011 PLOS Comp Bio, https://doi.org/10.1371/journal.pcbi.1002107 :Comment: corre...
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NEURON
1,551
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TITLE H-current that uses Na ions NEURON { SUFFIX h RANGE gbar,vhalf, K, taun, ninf, g ,ina USEION na READ ena WRITE ina : NONSPECIFIC_CURRENT i } UNITS { (um) = (micrometer) (mA) = (milliamp) (uA) = (microamp) (mV) = (millivolt) (pmho) = (picomho) (mmho) = (millimho) } ...
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/* * $Id: stim.hoc,v 1.5 2009/02/24 00:55:27 ted Exp ted $ * Set up stimulation waveform * 2018/05/20 Modified by Aman Aberra * Modified by Sina Shirinpour */ //n_time = tstop/dt+1 // number of time points objref stim_amp, stim_time stim_amp = new Vector()//n_time) stim_time = new Vector()//n_time) proc stim_wavefor...
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TITLE K-DR channel : from Klee Ficker and Heinemann : modified to account for Dax et al. : M.Migliore 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) } PARAMETER { v (mV) ek (mV) : must be explicitely def. in hoc celsius (degC) gkdrbar=.003 (mho/cm2) vhalfn=13 (mV) a0...
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NEURON
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TITLE CaGk : Calcium activated K channel. : Modified from Moczydlowski and Latorre (1983) J. Gen. Physiol. 82 UNITS { (molar) = (1/liter) } UNITS { (mV) = (millivolt) (mA) = (milliamp) (mM) = (millimolar) } NEURON { SUFFIX mykca USEION ca READ cai USEION k READ ek WRITE ik RANGE gkbar,ik ...
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COMMENT "NaV1.1" channel. BBP 'fast' Na channel, but activation/inactivation vHalf and slope adjusted to fit experimental data. ENDCOMMENT :Reference :Colbert and Pan 2002 : Adapted by Werner Van Geit @ BBP, 2015 (with help from M.Hines): : channel detects TTX concentration set by TTXDynamicsSwitch.mod NEURON { ...
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COMMENT Two state kinetic scheme described by rise time tau1, and decay time constant tau2. The normalized peak current is 1nA. Decay time MUST be greater than rise time. The solution of A->G->bath with rate constants 1/tau1 and 1/tau2 is A = a*exp(-t/tau1) and G = a*tau2/(tau2-tau1)*(-exp(-t/tau1) + exp(-t/t...
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// TREES package // neu_tree (name) // //Saves a neuron morphology into a conversion filetype // for the matlab TREES package. To keep things simple // please never load more than ONE cell before applying // this procedure. Read about restrictions in documentation // Run by calling: // // load_file("neu_tree.hoc") // n...
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// TREES package // neu_tree (name) // //Saves a neuron morphology into a conversion filetype // for the matlab TREES package. To keep things simple // please never load more than ONE cell before applying // this procedure. Read about restrictions in documentation // Run by calling: // // load_file("neu_tree.hoc") // n...
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NEURON
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TITLE Delayer rectifier COMMENT ----------------------------------------------------------------------------- "delayer-rectifier" K current for action potentials --------------------------------------------------- - potassium current, voltage-dependent - iterative equations Model of IKd for hippocampal pyram...
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NEURON
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TITLE Calcium dependent potassium channel : Implemented in Rubin and Cleland (2006) J Neurophysiology : Parameters from Bhalla and Bower (1993) J Neurophysiology : Adapted from /usr/local/neuron/demo/release/nachan.mod - squid : by Andrew Davison, The Babraham Institute [Brain Res Bulletin, 2000] :Suffix from...
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NEURON
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TITLE l-calcium channel : l-type calcium channel UNITS { (mA) = (milliamp) (mV) = (millivolt) FARADAY = 96520 (coul) R = 8.3134 (joule/degC) KTOMV = .0853 (mV/degC) } PARAMETER { v (mV) celsius= 34 (degC) gcalbar=0 (mho/cm2) ki=.001 (mM) cai = 50.e-6 (mM) cao = 2 (mM) tfa = 5 ...
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NEURON
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TITLE CaV 3.3 CA3 hippocampal neuron COMMENT Cell model: CA3 hippocampal neuron Created by jun xu @ Clancy Lab of Cornell University Medical College on 3/27/05 Geometry: single-compartment model modified on 04/19/07 Xu J, Clancy CE (2008) Ionic mechanisms of endogenous bursting in CA3 hippoc...
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NEURON
1,812
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TITLE Cerebellum Granule Cell Model COMMENT Reference: Theta-Frequency Bursting and Resonance in Cerebellar Granule Cells:Experimental Evidence and Modeling of a Slow K+-Dependent Mechanism Egidio D'Angelo,Thierry Nieus,Arianna Maffei,Simona Armano,Paola Rossi,Vanni Taglietti, Andrea Fontana and Giovanni Nal...
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NEURON
1,820
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TITLE Ca R-type channel with medium threshold for activation : used in somatic regions. It has lower threshold for activation/inactivation : and slower activation time constant : than the same mechanism in dendritic regions : uses channel conductance (not permeability) : written by Yiota Poirazi on 3/12/01 poirazi@LNC...
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NEURON
1,873
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TITLE Ca L-type channel with high treshold of activation : inserted in distal dendrites to account for distally : restricted initiation of Ca++ spikes : uses channel conductance (not permeability) : written by Yiota Poirazi, 1/8/00 poirazi@LNC.usc.edu NEURON { SUFFIX calH USEION ca READ eca WRITE ica RANGE g...
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NEURON
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TITLE I-h HCN1 channel from Kamilla Angelo, Michael London,Soren R. Christensen, and Michael Hausser 2007 J. of Neurosci. COMMENT We call it HCN1 as PC express only HCN1 Santoro et al. 2000 :aggiunta di correzione per Q10 by ERICA GRANDI ENDCOMMENT NEURON { SUFFIX HCN1 USEION h READ eh WRITE ih VALENCE 1...
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NEURON
1,920
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TITLE K-DR channel : from Klee Ficker and Heinemann : modified to account for Dax et al. : M.Migliore 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} PARAMETER { dt (ms) v (mV) ek = -90 (mV) : must be explicitely def. in hoc celsius = 24 (degC) gkdrba...
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NEURON
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COMMENT 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines (michael.hines@yale.edu) and Ruggero Scorcioni (rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal kca....
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NEURON
2,012
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TITLE na3 : Na current for axon. No slow inact. : M.Migliore Jul. 1997 NEURON { SUFFIX nax USEION na READ ena WRITE ina RANGE gbar GLOBAL minf, hinf, mtau, htau,thinf, qinf } PARAMETER { gbar = 0.010 (mho/cm2) :tha = -30 (mV) : v 1/2 for act tha = -30 (mV) : v 1/2 for ...
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NEURON
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TITLE Sodium channels COMMENT ----------------------------------------------------------------------------- Na current for action potentials -------------------------------- - fast sodium current - iterative equations Model of INa for hippocampal pyramidal cells, from Traub & Miles, Neuronal Networks of th...
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NEURON
2,038
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TITLE K-A channel from Klee Ficker and Heinemann : modified to account for Dax A Current --- M.Migliore Jun 1997 : modified to be used with cvode M.Migliore 2001 UNITS { (mA) = (milliamp) (mV) = (millivolt) } PARAMETER { v (mV) celsius (degC) gkabar=.008 (mho/cm2) vhalfn=11 (mV) ...
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NEURON
2,063
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TITLE K-A channel from Klee Ficker and Heinemann : modified to account for Dax A Current ---------- : M.Migliore Jun 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) } PARAMETER { celsius v (mV) gkabar=.008 (mho/cm2) vhalfn=-1 (mV) vhalfl=-56 (mV) ...
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NEURON
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COMMENT Conceptual model: Sodium current for a model of a fast-spiking cortical interneuron. Authors and citation: Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007). Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156. Original implementation and pr...
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NEURON
2,200
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TITLE Low threshold calcium current : : Ca++ current responsible for low threshold spikes (LTS) : RETICULAR THALAMUS : Differential equations : : Model of Huguenard & McCormick, J Neurophysiol 68: 1373-1383, 1992. : : Written by Alain Destexhe, Salk Institute, Sept 18, 1992 : : - Biophysica...
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/* * Procedures for generating GUI panels for choosing E-field parameters * AUTHOR: Sina Shirinpour, University of Minnesota * CONTACT: shiri008[at]umn.edu */ objref shplot, pElec,sElec_list // for shape plot /* proc getes(){ E_uniform = $4 if (E_uniform){ getes_uniform($1, $2, $3) } else { getes_realis...
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NEURON
2,354
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TITLE na3 : Na current for axon. No slow inact. : M.Migliore Jul. 1997 INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX nax USEION na READ ena WRITE ina RANGE gbar, ina, thegna RANGE minf, hinf, mtau, htau GLOBAL thinf, qinf, mscale, hscale } PARAMETER { gbar = 0.010 (mho/cm2) tha...
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NEURON
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COMMENT 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines (michael.hines@yale.edu) and Ruggero Scorcioni (rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal km.m...
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NEURON
2,412
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TITLE SK2 multi-state model Cerebellum Golgi Cell Model COMMENT Author:Sergio Solinas, Lia Forti, Egidio DAngelo Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998 Last revised: May 2007 Published in: Sergio M. Solinas, Lia Forti, Elisabetta Cesana, Jonathan Mapell...
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NEURON
2,435
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TITLE Ca R-type channel with medium threshold for activation : used in distal dendritic regions, together with calH.mod, to help : the generation of Ca++ spikes in these regions : uses channel conductance (not permeability) : written by Yiota Poirazi on 11/13/00 poirazi@LNC.usc.edu : : updated to use CVode by Car...
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NEURON
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// Connection Probability Prob_PN2PN = 0.15//0.10 Prob_PN2MN = 0.10//0.05 Prob_PN2BN = 0.10//0.05 Prob_PN2VN = 0.10//0.05 Prob_MN2PN = 0.20//0.15 Prob_MN2MN = 0.10//0.05 Prob_MN2BN = 0.10//0.05 Prob_MN2VN = 0.10//0.05 Prob_BN2PN = 0.20//0.15 Prob_BN2MN = 0.10//0.05 Prob_BN2BN = 0.10//0.05 Prob_BN2VN = 0.10//0.05 Pro...
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NEURON
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COMMENT 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines (michael.hines@yale.edu) and Ruggero Scorcioni (rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal Int...
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NEURON
2,621
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TITLE P-type calcium channel COMMENT Constructed from the recording data provided by Bruce Bean. Reference: Swensen AM and Bean BP (2005) Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci 25:3509-20 Current Model Reference: Anwar H, Hong S...
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NEURON
2,631
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TITLE decay of internal calcium concentration : : Internal calcium concentration due to calcium currents and pump. : Differential equations. : : Simple model of ATPase pump with 3 kinetic constants (Destexhe 92) : Cai + P <-> CaP -> Cao + P (k1,k2,k3) : A Michaelis-Menten approximation is assumed, which red...
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NEURON
2,641
118
TITLE Cardiac IKur current & nonspec cation current with identical kinetics : Hodgkin - Huxley type channels, modified to fit IKur data from Feng et al Am J Physiol 1998 275:H1717 - H 1725 : Suffix from Kv15 to Kv1_5 NEURON { SUFFIX Kv1_5 USEION k READ ek WRITE ik :,ki,ko :USEION na READ nai,nao :USEION n...
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NEURON
2,665
132
TITLE na3 : Na current : from Jeff M. : ---------- modified -------M.Migliore may97 NEURON { SUFFIX na3dend USEION na READ ena WRITE ina RANGE gbar, ar2 GLOBAL minf, hinf, mtau, htau, sinf, taus,qinf, thinf } PARAMETER { gbar = 0.010 (mho/cm2) tha = -23 (mV) : v 1/2 for act q...
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NEURON
2,670
132
TITLE na3 : Na current : from Jeff M. : ---------- modified -------M.Migliore may97 NEURON { SUFFIX na3notrunk USEION na READ ena WRITE ina RANGE gbar, ar2 GLOBAL minf, hinf, mtau, htau, sinf, taus,qinf, thinf } PARAMETER { gbar = 0.010 (mho/cm2) tha = -23 (mV) : v 1/2 for act ...
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NEURON
2,693
120
TITLE Cardiac IKur current & nonspec cation current with identical kinetics : Hodgkin - Huxley type channels, modified to fit IKur data from Feng et al Am J Physiol 1998 275:H1717 - H 1725 : Suffix from Kv15 to Kv1_5 NEURON { SUFFIX Kv1_5 USEION k READ ek WRITE ik : is not working with ,ki,ko :USEION na REA...
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NEURON
2,708
133
TITLE na3 : Na current : from Jeff M. : ---------- modified -------M.Migliore may97 NEURON { SUFFIX na3 USEION na READ ena WRITE ina RANGE gbar, ar2,ina GLOBAL minf, hinf, mtau, htau, sinf, taus,qinf, thinf } PARAMETER { gbar = 0.010 (mho/cm2) tha = -25(mV) : v 1/2 for act q...
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NEURON
2,731
149
TITLE K-A channel from Klee Ficker and Heinemann : modified to account for Dax A Current ---------- : M.Migliore Jun 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} PARAMETER { dt (ms) v (mV) ek = -90 (mV) : must be explicitely def. in hoc...
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NEURON
2,737
141
TITLE Voltage-gated potassium channel from Kv3 subunits COMMENT Voltage-gated potassium channel with high threshold and fast activation/deactivation kinetics KINETIC SCHEME: Hodgkin-Huxley (n^4) n'= alpha * (1-n) - betha * n g(v) = gbar * n^4 * ( v-ek ) The rate constants of activation (alpha) and deactivat...
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NEURON
2,739
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TITLE hh2.mod sodium, potassium, and leak channels COMMENT This is an adjusted Hodgkin-Huxley treatment for sodium, potassium, and leakage channels. Membrane voltage is in absolute mV and has been reversed in polarity from the original HH convention and shifted to reflect a resting potential of -65 mV. Re...
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NEURON
2,746
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TITLE AMPA and NMDA receptor with presynaptic short-term plasticity COMMENT AMPA and NMDA receptor conductance using a dual-exponential profile presynaptic short-term plasticity based on Fuhrmann et al. 2002 Implemented by Srikanth Ramaswamy, Blue Brain Project, July 2009 GUY: Removed plasticity and depression END...
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2,751
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TITLE K-A channel from Klee Ficker and Heinemann : modified to account for Dax A Current ---------- : M.Migliore Jun 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) (mS) = (millisiemens) } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} PARAMETER { dt (ms) v (mV) ek = -90 (mV) : must be e...
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NEURON
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COMMENT 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines(michael.hines@yale.edu) and Ruggero Scorcioni (rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal ca.mo...
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NEURON
2,790
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TITLE T-calcium channel UNITS { (mA) = (milliamp) (mV) = (millivolt) (molar) = (1/liter) (mM) = (millimolar) FARADAY = 96520 (coul) R = 8.3134 (joule/degC) KTOMV = .0853 (mV/degC) } NEURON { SUFFIX cat USEION ca READ cai,cao USEION Ca WRITE iCa VALENCE 2 : The T-cur...
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NEURON
2,802
144
TITLE Low threshold calcium current Cerebellum Purkinje Cell Model COMMENT Kinetics adapted to fit the Cav3.1 Iftinca et al 2006, Temperature dependence of T-type Calcium channel gating, NEUROSCIENCE Reference: Anwar H, Hong S, De Schutter E (2010) Controlling Ca2+-activated K+ channels with models of Ca2+ buffering...
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NEURON
2,804
145
TITLE Voltage-gated low threshold potassium current from Kv1 subunits COMMENT NEURON implementation of a potassium channel from Kv1.1 subunits Kinetical scheme: Hodgkin-Huxley m^4, no inactivation Experimental data taken from: Human Kv1.1 expressed in xenopus oocytes: Zerr et al., J Neurosci 18, 2842, 2848, ...
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begintemplate Temperature external strf, cellList public init, reset, correct proc init() { q10_g_pas = 1.98 // simulations. Passive membrane parameters (Ra, cm, g_pas) q10_Ra = 0.80 // have no built-in temperature dependence. Instead, they q10_cm = 0.96 // will be scaled when calling membrane...
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//objref midSecX, midSecY, midSecZ strdef s, result_folder proc exportLocs_seg(){ localobj savLocs, savDiam, sref // all segment locs neuron_section_size = 0 savLocs = new File() sprint(s,"../../Results/NEURON/locs/locs_all_seg.txt") savLocs.wopen(s) forall{ // loop over all sections sref =...
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NEURON
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obfunc init_cell() {localobj model if (strcmp($s1, "HL23MN1") == 0){ model = new NeuronTemplate("morphologies/HL23MN1.swc", "HL23MN1") biophys_HL23MN1(model) } if (strcmp($s1, "HL23PN1") == 0){ model = new NeuronTemplate("morphologies/HL23PN1.swc", "HL23PN1") biophys_HL23PN1(model) } if (strcmp($s...
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: Vector stream of events COMMENT A VecStim is an artificial spiking cell that generates events at times that are specified in a Vector. --- AES: This newer version of vecevent.mod was taken from https://github.com/neuronsimulator/nrn/blob/master/share/examples/nrniv/netcon/vecevent.mod as of this commit https://git...
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NEURON
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: $Id: netstim.mod,v 1.1.1.1 2001/01/01 20:30:37 hines Exp $ : modified in such a way that the first event will never be before start : M.Migliore Dec.2001 : modified in such a way to have the first event at start : M.Migliore Sep. 2003 NEURON { POINT_PROCESS NetStims RANGE y RANGE interval, number, st...
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NEURON
3,361
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TITLE dual-exponential model of NMDA receptors COMMENT Classic double-exponential model of NMDAR Mg++ voltage dependency from Spruston95 -> Woodhull, 1973 Keivan Moradi 2011 --- (and now back to the original exp2syn comments) --- Two state kinetic scheme synapse described by rise time tau1, and decay time constant...
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NEURON
3,362
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TITLE na3 : Na current : from Jeff M. : ---------- modified -------M.Migliore may97 INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX na3 USEION na READ ena WRITE ina RANGE gbar, ar2, ina, thegna RANGE minf, hinf, mtau, htau, sinf, taus, tauss GLOBAL qinf, thinf, mscale, hscale, sscale } PARAME...
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NEURON
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NEURON { ARTIFICIAL_CELL mpi_input RANGE interval, number, start, time_synch THREADSAFE : if APCount.record uses distinct instances of Vector } PARAMETER { interval = 10 (ms) <1e-9,1e9>: time between spikes (msec) number = 10 <0,1e9> : number of spikes (independent of noise) start = 50 (ms) : start of firs...
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NEURON
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TITLE Cerebellum Granule Cell Model COMMENT KA channel Author: E.D'Angelo, T.Nieus, A. Fontana Last revised: Egidio 3.12.2003 :Suffix from GRC_KA to Kv4_3 ENDCOMMENT NEURON { SUFFIX Kv4_3 USEION k READ ek WRITE ik RANGE gkbar, ik, g, alpha_a, beta_a, alpha_b, beta_b RANGE Aalpha_a,...
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begintemplate Location2 public secRef, loc objref secRef proc init() { secRef = new SectionRef() loc = $1 } endtemplate Location2 proc read_params(){local THETA, PHI, bPolar localobj params, timing TMSAMP = 1 // Default value if not specified SYN_FREQ = 25 SYN_NOISE = 0.5 SYN_WEIGHT = 0.001 SYNC_WEIGH...
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TITLE Large conductance Ca2+ activated K+ channel mslo COMMENT Parameters from Cox et al. (1987) J Gen Physiol 110:257-81 (patch 1). Current Model Reference: Anwar H, Hong S, De Schutter E (2010) Controlling Ca2+-activated K+ channels with models of Ca2+ buffering in Purkinje cell. Cerebellum* *Article available as...
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// Author: Alexandre Guet-McCreight // // Adapted from: // Etay Hay 2014 // Dendritic excitability and gain control in recurrent cortical microcircuits (Hay and Segev, 2014, Cerebral Cortex) // // Parallel simulation code for microcircuits of human L2/3 neurons //===============================================...
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proc GUI(){ E_UNIFORM = 1 xpanel("E-field Type") xlabel("Choose how extracllular potentials are calculated:") xradiobutton("Uniform Electric Field", "E_UNIFORM=1",1) xradiobutton("Realistc Electric Field", "E_UNIFORM=0") xbutton("Select","E_field_params()") xpanel() } proc E_field_params(){ localobj pwm...
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TITLE simple NMDA receptors : Modified from the original AMPA.mod, M.Migliore Jan 2003 : A weight of 0.0035 gives a peak conductance of 1nS in 0Mg COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ===============================...
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NEURON
4,493
170
TITLE Fluctuating conductances COMMENT ----------------------------------------------------------------------------- Fluctuating conductance model for synaptic bombardment ====================================================== THEORY Synaptic bombardment is represented by a stochastic model containing two flu...
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TITLE COMMENT ENDCOMMENT NEURON { POINT_PROCESS PF_syn NONSPECIFIC_CURRENT i RANGE Q10_diff,Q10_channel RANGE R, g, ic RANGE Cdur, Erev RANGE r1FIX, r2, r3,r4,r5,gmax,r1,r6,r6FIX,kB RANGE tau_1, tau_rec, tau_facil, U RANGE PRE,T,Tmax,x RANGE y_read,z_read,u_read RANGE C,O,D RANGE diffuse,Trelease,la...
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NEURON
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TITLE resurgent sodium channel COMMENT Neuron implementation of a resurgent sodium channel (with blocking particle) Based om updated kinetic parameters from Raman and Bean, Biophys.J. 80 (2001) 729 Modified from Khaliq et al., J.Neurosci. 23(2003)4899 by qt-correction of all rate constants Laboratory for...
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NEURON
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TITLE resurgent sodium channel COMMENT Neuron implementation of a resurgent sodium channel (with blocking particle) Based om updated kinetic parameters from Raman and Bean, Biophys.J. 80 (2001) 729 Modified from Khaliq et al., J.Neurosci. 23(2003)4899 by qt-correction of all rate constants Laboratory for...
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NEURON
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TITLE Slow Ca-dependent potassium current : : Ca++ dependent K+ current IC responsible for slow AHP : Differential equations : : Model based on a first order kinetic sch...
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TITLE simple NMDA receptors COMMENT ----------------------------------------------------------------------------- Essentially the same as /examples/nrniv/netcon/ampa.mod in the NEURON distribution - i.e. Alain Destexhe's simple AMPA model - but with different binding and unbinding rates and with a magnesiu...
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: $Id: gabab.mod,v 1.9 2004/06/17 16:04:05 billl Exp $ : Taken from Neymotin 2016 https://doi.org/10.1016/j.neuroscience.2015.12.043 : COMMENT ----------------------------------------------------------------------------- Kinetic model of GABA-B receptors ================================= MODEL OF SECOND-ORDER G-...
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TITLE Gaba mod file only for fitting purpose COMMENT Thierry Nieus, unpublished results, please keep reserved. Variables with suffix "_s" are meant for single IPSC fit, with suffix "_2" for CGP experimental condition Does not work with variable dt! ENDCOMMENT NEURON { POINT_PROCESS PC_gaba_alpha1 NONSPECIFIC...
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begintemplate NeuronTemplate public init, delete_axon, delete_axon_BPO, insertChannel, distribute, geom_nseg public set_parameters, locateSites, getLongestBranch, distribute_channels, connect2target public initRand, indexSections, cell_name, rd1, pA public all, apical, basal, somatic, axonal, nSecAll, nSecSoma, ...
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proc init() { realtime = 0 dtsav = dt // Save desired dt value to reset after temporarily changing dt secondordersav = secondorder // Save desired secondorder value to reset after temporarily changing secondorder finitialize(v_init) // Call finitialize (since we are replacing the default init proc that calls...
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module github.com/chroma-core/chroma/go go 1.23.0 toolchain go1.23.10 require ( ariga.io/atlas-provider-gorm v0.3.1 github.com/DATA-DOG/go-sqlmock v1.5.2 github.com/aws/aws-sdk-go-v2 v1.36.3 github.com/aws/aws-sdk-go-v2/config v1.28.6 github.com/aws/aws-sdk-go-v2/credentials v1.17.47 github.com/aws/aws-sdk-go-...
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: Calcium ion accumulation with endogenous buffers, DCM and pump COMMENT The basic code of Example 9.8 and Example 9.9 from NEURON book was adapted as: 1) Extended using parameters from Schmidt et al. 2003. 2) Pump rate was tuned according to data from Maeda et al. 1999 3) DCM was introduced and tuned to approximate...
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/* Adapted from interpxyz.hoc: * $Id: interpxyz.hoc,v 1.2 2005/09/10 23:02:15 ted Exp $ * 2018/05/20 Modified by Aman Aberra * AUTHOR: Aman Aberra, Duke University * CONTACT: aman.aberra@duke.edu */ // original data, irregularly spaced objref xx, yy, zz, length // interpolated data, spaced at regular intervals objref ...
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/* Created by BluePyOpt(1.5.3) at 2020-05-02 08:46:08.997716 */ {load_file("stdrun.hoc")} {load_file("import3d.hoc")} /* * Check that global parameters are the same as with the optimization */ proc check_parameter(/* name, expected_value, value */){ strdef error if($2 != $3){ sprint(error, "Parameter %s has d...
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/* Created by BluePyOpt(1.5.3) at 2020-05-02 08:46:08.997716 */ {load_file("stdrun.hoc")} {load_file("import3d.hoc")} /* * Check that global parameters are the same as with the optimization */ proc check_parameter(/* name, expected_value, value */){ strdef error if($2 != $3){ sprint(error, "Parameter %s has d...
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//======================================================================================== //============================== position related functions ============================== //======================================================================================== proc rotateZ(){ local i c = cos($1) s = sin(...
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// ---------------------------------------------------------------------------- // morpho.hoc // stand-alone morphology file // // 2007-06-17, Christoph Schmidt-Hieber, University of Freiburg // // accompanies the publication: // Schmidt-Hieber C, Jonas P, Bischofberger J (2007) // Subthreshold Dendritic Signal Process...
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/* This is a CellBuilder-like file written for the simulator NEURON by an automatic procedure "neuron_tree" part of the TREES package in MATLAB copyright 2009 Hermann Cuntz */ begintemplate GC7 proc celldef() { topol() subsets() geom() biophys() geom_nseg() } public soma public adendGCL public adendIML pub...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ########################################################################################## ## Script to convert Illumina Manifests files into Intervals.list GATK files ## ## Also works for BED to intervals ## ## david bau...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ########################################################################################################## ## Script to remove genes from an annotated file (tsv format) ## ## david baux 11/2015 ## ## david.baux@ins...
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#!/usr/bin/env perl use POSIX qw/WEXITSTATUS/; my $vtag = "v[0-9]*"; sub git { my $args = shift; my $output = `git $args 2>&1`; my $rc = WEXITSTATUS($?); die "git command '$args' returned $rc. output was '$output'" if $rc; chomp $output; return $output; } sub is_git_repo { eval { git("st...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ########################################################################################################## ## Script to mark genes from an annotated file (tsv format) ## ## david baux 10/2016 ...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ########################################################################################################## ## Script to remove genes from an annotated file (tsv format) ## ## david baux 11/2015 ## ## david.baux@ins...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ############################################################################################################ ## Script to put a barcode resuming genotypes in an annotated txt variant file with multiple samples ## ## david baux ...
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#!/usr/bin/perl -wT use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ########################################################################################################## ## Script to merge annotation files form cava and annovar, obtained from IURC_VFC_ANNOT_1.2.sh ## ## david baux 11/2015 ...
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#!/usr/bin/perl -w use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ############################################################################################################ ## Script to put a LED (Lgm Exome Database) to get occurence of variants in the lab ## ## david baux 08/2016 ...
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#!/usr/bin/perl -w use strict; use Getopt::Std; $Getopt::Std::STANDARD_HELP_VERSION = 1; ################################################################################################### ### script to add spidex results to tsv files ### ### david baux 2015 david.baux@inserm.fr ### ###################...