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TITLE jsr.mod VCN conductances COMMENT Ih for VCN neurons - average from several studies in auditory neurons Implementation by Paul B. Manis, April (JHU) and Sept, (UNC)1999. revised 2/28/04 pbm pmanis@med.unc.edu Modifed implementation; includes all temperature scaling, passes modlunit 7/10/2014 pbm ENDCOMMENT ...
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: HH TEA-sensitive Purkinje potassium current : Created 8/5/02 - nwg NEURON { THREADSAFE SUFFIX kpkj USEION k READ ek WRITE ik RANGE gbar, ik, gk GLOBAL minf, hinf, mtau, htau } UNITS { (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { v (mV) gbar = .004 (mho/cm2) mivh = -24 (mV) mik = 15.4 (mV) mt...
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TITLE kdrglia : Kalium delayed rectifier (AHP) : twee gates met elk twee toestanden : : uit: Traub et al. : A branching dendritic model of a rodent CA3 : pyramidal neurone. UNITS { (molar) = (1/liter) (mV) = (millivolt) (mA) = (milliamp) (mM) = (millimolar) } INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)} NEURON { ...
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COMMENT Iclamp2.mod: Electrode current injection, revised for our own use I specifically needed more step changes in a single waveform than were provided by the default code. This routine gives us 5 levels: holding, 3 steps, and a final (holding?) level. This version generates a pulse of duration at amplitude I for ...
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: HH P-type Calcium current : Created 8/13/02 - nwg NEURON { THREADSAFE SUFFIX cap USEION ca READ cai, cao WRITE ica RANGE pcabar, ica RANGE minf, mtau RANGE monovalConc, monovalPerm } UNITS { (mV) = (millivolt) (mA) = (milliamp) (mM) = (milli/liter) F = 9.6485e4 (coul) R = 8.3145 (joule/degC) } PARA...
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//Geometry of EndFoot create EndFoot[4] connect soma[0](1), EndFoot[0](0) //connect EndFoot[0](1), EndFoot[1](0) //connect EndFoot[0](1), EndFoot[2](0) EndFoot[0] { pt3dclear() pt3dadd(-1,-1.67,0.12,1.34) pt3dadd(-0.67,-1.34,0.12,1.34) pt3dadd(-0.67,-0.67,0.12,1.34) pt3dadd(-0.33,0,0.12,1.34) pt3d...
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UNITS { (mA) = (milliamp) (mV) = (millivolt) (molar) = (1/liter) (mM) = (millimolar) F = 96485 (coul) R = 8.3134 (joule/degC) } PARAMETER { v (mV) celsius (degC) PcalBar=0.00006622 (cm/s) ki=.00002 (mM) cai=5.e-5 (mM) cao = 10 (mM) q10m=11.45 q10Ampl=2.1 }...
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TITLE kir.mod COMMENT Inwardly rectifying potassium (Kir) currents based on mathematical model from Leao et al (2012) Ceballos CC, Li S, Roque AC, Tzounopoulos T, Leão RM (2016) Ih Equalizes Membrane Input Resistance in a Heterogeneous Population of Fusiform Neurons in the Dorsal Cochlear Nucleus. Front Cell Neuro...
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UNITS { (mA) = (milliamp) (mV) = (millivolt) : hier eigene Befehle (molar) = (1/liter) (mM) = (millimolar) F = 96485 (coul) R = 8.3134 (joule/degC) } PARAMETER { v (mV) celsius (degC) PcalBar=0.00006622 (cm/s) ki=.00002 (mM) cai=5.e-5 (mM) cao = 10 (mM) q10m=11.45 q10Ampl=2.1 } NEUR...
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objref VFSec[10000000] //GapJunctionMaxNumber=800 for i = 1, NumberDendrites-SeedNumber-1 { dendrite[i] connect dendrite[i+SeedNumber](0), 1 //264 access dendrite[i+SeedNumber] { L=0.1 diam=3 } // L and dim in um define the geometry of small seeds pt3dclear() } soma { Ra = 100 // Ohm cm c...
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COMMENT kca.mod Calcium-dependent potassium channel Based on Pennefather (1990) -- sympathetic ganglion cells taken from Reuveni et al (1993) -- neocortical cells Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu Kole: the caix increased from 1 -> 4, Ra 0.01 to 0.05 and Rb 0.02 to 0.1, according to Schaefer ...
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NEURON
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// Octopus cell, stick representation // From Spencer et al., Front. Comput. Neurosci., 22 October 2012 | https://doi.org/10.3389/fncom.2012.00083 // Figure 1. objref soma soma = new SectionList() objref primarydendrite primarydendrite = new SectionList() objref hillock hillock = new SectionList() objref unmyelinateda...
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objref soma soma = new SectionList() objref primarydendrite primarydendrite = new SectionList() objref secondarydendrite secondarydendrite = new SectionList() objref hillock hillock = new SectionList() objref unmyelinatedaxon unmyelinatedaxon = new SectionList() objref myelinatedaxon myelinatedaxon = new SectionList() ...
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: CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010) : The file was downloaded from https://senselab.med.yale.edu/ModelDB/showmodel.cshtml?model=125152 UNITS { (mA) = (milliamp) (mV) = (millivolt) (molar) = (1/liter) (mM) = (millimolar) F = 96485 (coul) ...
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load_file("CalciumParameters.hoc") // UI objref vBoxCaWave, plotShapeCaWaveCai, graphCaWaveCai // Sets initial UI and simulation params. proc initParamsCaWave() { TimeDelayCaWave = 1000 InitIp3 = 0.05 } // Shows Calcium Wave UI. proc showCaWaveUi() { vBoxCaWave = new VBox() vBoxCaWave.intercept(1) ...
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objref soma soma = new SectionList() objref primarydendrite primarydendrite = new SectionList() objref secondarydendrite secondarydendrite = new SectionList() objref hillock hillock = new SectionList() objref unmyelinatedaxon unmyelinatedaxon = new SectionList() objref myelinatedaxon myelinatedaxon = new SectionList() ...
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TITLE decay of internal calcium concentration : : Internal calcium concentration due to calcium currents and pump. : Differential equations. : : Simple model of ATPase pump with 3 kinetic constants (Destexhe 92) : Cai + P <-> CaP -> Cao + P (k1,k2,k3) : A Michaelis-Menten approximation is assumed, which reduces t...
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// This file is original file from Neuron Data base // https://senselab.med.yale.edu // Accession:97985 //A 3-d reconstructed neuron model can be simulated in parallel on a dozen or so processors and experience almost linear speedup. Network models can be simulated when there are more processors than cells. //Referenc...
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// UI objref vBoxFrequencySimulations // IClampSin on soma objref stimFreq // Sets IClampSin params on the soma. // $1 - Delay // $2 - Duration // $3 - Frequency // $4 - Amplitude // $5 - Phase proc simulateFrequency() { soma { stimFreq = new IClampSin(0.5) stimFreq.del = $1 // ms st...
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COMMENT kv.mod Potassium channel, Hodgkin-Huxley style kinetics Kinetic rates based roughly on Sah et al. and Hamill et al. (1991) Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu ENDCOMMENT INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX Kv USEION k READ ek WRITE ik RANGE n, gk, gbar RANGE ...
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COMMENT cleftXmtr This is simple state model that generates "cleft" transmitter, through the following scheme: A netreceive block receives the driving event. This forces XV (the vesicle state) to be set to XMax to mimic the release of a vesicle. Then: XV --> XC --> XU where XV is the vesicle transmitter, XC is the cl...
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TITLE kdpyr.mod DCN pyramidal cell model, delayed rectifier COMMENT This is part of a model implements a Dorsal Cochlear Nucleus Pyramidal point cell based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis Added export of start states for some variables to...
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TITLE Slow Ca-dependent potassium current : : Ca++ dependent K+ current IC responsible for slow AHP : Differential equations : : Model based on a first order kinetic scheme : : <closed> + n cai <-> <open> (alpha,beta) : : Following this model, the activation fct will be half-activated at : a concentrati...
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TITLE T-type calcium channel (Cav3.3) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { SUFFIX cav33 USEION ca READ cai, cao WRITE ica VALENCE 2 RANGE pbar, mvh...
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TITLE Glutamate-induced glutamate release (GIGR) UNITS { (molar) = (1/liter) (mM) = (millimolar) (uM) = (micromolar) } NEURON { POINT_PROCESS gigr RANGE K2, K5, KX, KY, KZ, kc, kf, eps, V0, V1, VM2, VM3, V4, VM5 RANGE n, r1, r2, r3, ru, rb, V, B, Rmax, VmaxA, VmaxN, KN, KA, abg RANGE x0, y...
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TITLE h current for Octopus cells of Cochlear Nucleus : From Bal and Oertel (2000) : Modified, P. Manis July 2014, 2017 : Parameters from McGinley et al. paper NEURON { THREADSAFE SUFFIX hcnobo NONSPECIFIC_CURRENT i RANGE gbar, eh, gh, q10tau GLOBAL hinf, tau1, tau2 } UNITS { (mA) = (millia...
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COMMENT changed from (AS Oct0899) ca.mod to lead to thalamic ca current inspired by destexhe and huguenrd Uses fixed eca instead of GHK eqn ENDCOMMENT INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX it2 USEION ca READ eca WRITE ica RANGE m, h, gcaT, icaT, gcabar RANGE minf, hinf, mtau, htau, inactF, ac...
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TITLE T-type calcium channel (Cav3.2) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { SUFFIX cav32 USEION ca READ cai, cao WRITE ica VALENCE 2 RANGE pbar, ica...
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COMMENT ca.mod Uses fixed eca instead of GHK eqn HVA Ca current Based on Reuveni, Friedman, Amitai and Gutnick (1993) J. Neurosci. 13: 4609-4621. Author: Zach Mainen, Salk Institute, 1994, zach@salk.edu ENDCOMMENT INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX ca USEION ca READ eca WRITE ica RANGE m, ...
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TITLE CaPCalyx.mod The presynaptic calcium current at the MNTB calyx of Held COMMENT NEURON implementation of Calcium current from Borst and Sakmann, 1998. Equations are basic HH; parameters are taken from Figure 8 legend in that paper. Original implementation by Paul B. Manis, October 2007 Contact: pmanis@med.unc...
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TITLE h current for Octopus cells of Cochlear Nucleus : From Bal and Oertel (2000) : M.Migliore Oct. 2001 : Modified, P. Manis July 2014. NEURON { THREADSAFE SUFFIX hcno NONSPECIFIC_CURRENT i RANGE gbar, eh, gh GLOBAL hinf, tau1, tau2 } UNITS { (mA) = (milliamp) (mV) = (millivolt) (pS...
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: the dynamics mechanism of the FRAP is developed by Savchenko and others. 2018 NEURON { SUFFIX FRAP USEION frapion READ frapiono, frapioni WRITE frapioni VALENCE 1 GLOBAL vol, Buffer0 RANGE frapion0, Alpha } DEFINE NANN 4 UNITS { (molar) = (1/liter) (mM) = (millimolar) (um) = (micron) ...
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: BK-type Purkinje calcium-activated potassium current : Created 8/19/02 - nwg NEURON { THREADSAFE SUFFIX bkpkj USEION k READ ek WRITE ik USEION ca READ cai RANGE gbar, ik, gbkpkj GLOBAL minf, mtau, hinf, htau, zinf, ztau GLOBAL m_vh, m_k, mtau_y0, mtau_vh1, mtau_vh2, m...
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TITLE nacn.mod A sodium conductance for a ventral cochlear nucleus neuron model COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements the average brain sodium current used in the Rothman model. In the absence of direct measurements in the VCN, this is a fair assumpt...
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TITLE T-type calcium current (Cav3.2) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { SUFFIX cat32 USEION ca READ cai, cao WRITE ica VALENCE 2 RANGE pbar, ica...
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TITLE T-type calcium current (Cav3.3) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { SUFFIX cat33 USEION ca READ cai, cao WRITE ica VALENCE 2 RANGE pbar, ica...
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// UI objref vBoxSpatialVoltage, voltagePlot, graphDendrogramm // IClamp on soma objref currentDendrogramm // Sets IClamp params on the soma. // $1 - Amplitude // $2 - Duration proc stimulDendro() { soma { currentDendrogramm = new IClamp(0.5) currentDendrogramm.del = 0 // ms currentDendrog...
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TITLE na.mod A sodium channel for cochlear nucleus neurons COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements the average brain sodium current used in the Rothman model. In the absence of direct measurements in the VCN, this is a fair assumption. The model differ...
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TITLE kis.mod DCN pyramidal cell model Slow transient K current COMMENT This model implements the slow transient potassium current from Dorsal Cochlear Nucleus Pyramidal cells based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis 2/10/02, 7/24/2014. P. Manis....
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: 6-state bushy cell model from Yang, Ramamurthy, Neef and Xu-Friedman : "Low somatic sodium conducdtance... " J. Neurosci 26: 11999, 2016 : : Implementation by P.B. Manis : Kinetic data taken from Table 1 : Transition states from Figure 3A NEURON { THREADSAFE SUFFIX nabu USEION na READ ena WRITE ina R...
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TITLE decay of submembrane calcium concentration : : Internal calcium concentration due to calcium currents and pump. : Differential equations. : : This file contains two mechanisms: : : 1. Simple model of ATPase pump with 3 kinetic constants (Destexhe 1992) : : Cai + P <-> CaP -> Cao + P (k1,k2,k3) : : A Mich...
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TITLE inward rectifier potassium (Kir) channel COMMENT Mod File by A. Hanuschkin <AH, 2011> for: Yim MY, Hanuschkin A, Wolfart J (2015) Hippocampus 25:297-308. http://onlinelibrary.wiley.com/doi/10.1002/hipo.22373/abstract Channel description and parameters from: Stegen M, Kirchheim F, Hanuschkin A, Staszewski O, Ve...
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// Diameter distribution objref diamDistrLeaves, diamDistrStalks diamStep = 0 nanoDistrLoaded = 0 // Boolean // Random objref randomDiameters randomDiameters = new Random() // Shows window to select a .TXT file with diameter distribution. proc loadDiamDistrFile() { local divisions localobj radiiFile, line, neuronLine,...
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TITLE nap.mod Persistent sodium conductance COMMENT Persistent sodium current from deSchutter and Bower, J. Neurophys. 71:375, 1994. 2/10/02, 10/10/2014. P. Manis. ENDCOMMENT UNITS { (mA) = (milliamp) (mV) = (millivolt) } NEURON { THREADSAFE SUFFIX nap USEION na READ ena WRITE ina RANGE nap_inf,...
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NEURON { SUFFIX GluTrans8st RANGE part, C1, C2, C3, C4, C5, C6, C7, C8 GLOBAL k12, k21, k23, k32, k34, k43, k45, k54, k56, k65, k67, k76, k78, k87, k18, k81 GLOBAL Nain, Naout, Kin, Kout, Gluin, charge RANGE itrans, Gluout, density NONSPECIFIC_CURRENT itrans } UNITS { (l) = (liter) (nA) = (nanoamp) (...
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// This file is original file from Neuron Data base // https://senselab.med.yale.edu // Accession:97985 //A 3-d reconstructed neuron model can be simulated in parallel on a dozen or so processors and experience almost linear speedup. Network models can be simulated when there are more processors than cells. //Referenc...
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TITLE ihpyr.mod DCN pyramidal cell model H-current COMMENT This model is part a Dorsal Cochlear Nucleus Pyramidal point cell based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis Added export of start states for some variables to do perturbation tests These s...
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TITLE simple AMPA receptors NEURON { POINT_PROCESS adaptive_zahra_AMPA RANGE R, g, ina, Alpha, Beta, iAMPA USEION na WRITE ina NONSPECIFIC_CURRENT iAMPA POINTER weight RANGE g, Alpha, Beta, Erev, gmax, Cdur, iNMDA,mg, Cmax, eta, alpha, treshf,synon,flag USEION ca_nmda READ ca_nmdai WRITE ica_nmda VALENCE ...
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objref trajectories_tvec // vector of doubles objref trajectories_name // list of strings objref trajectories_vvec // list of vectors of doubles trajectories_name = new List() trajectories_vvec = new List() // $o1 - (list of strings) the name of section array where the watched variable resides, e.g. { "soma...
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TITLE Axonal voltage-gated potassium current COMMENT Hallermann, de Kock, Stuart and Kole, Nature Neuroscience, 2012 doi:10.1038/nn.3132 n8*h1 + n8*h2 Hodgkin-Huxley model ENDCOMMENT NEURON { SUFFIX Kv1 USEION k READ ek WRITE ik RANGE gkv1, ikv1, gbar GLOBAL ninf, ntau GLOBAL h1inf, h1tau GLOBAL h2inf, h2...
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TITLE R-type calcium current (Cav2.3) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { SUFFIX car USEION ca READ cai, cao WRITE ica VALENCE 2 RANGE pbar, ical ...
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TITLE klt.mod The low threshold conductance of cochlear nucleus neurons COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements the transient potassium current found in ventral cochlear nucleus "Type I" cells, which are largely "stellate" or "multipolar" cells (Manis...
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: $Id: pregen.mod 3 2003-02-11 18:36:05Z hines $ : comments at end NEURON { POINT_PROCESS SpikeGenerator RANGE y RANGE fast_invl, slow_invl, burst_len, start, end RANGE noise } PARAMETER { fast_invl = 1 (ms) : time between spikes in a burst (msec) slow_invl = 50 (ms) : burst period (msec) : actually, above...
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load_file("nrngui.hoc") load_file("CellInit.hoc") load_file("CellUpdate.hoc") load_file("MechanismSwitch.hoc") load_file("MainUi.hoc") load_file("GeometricalParameters.hoc") load_file("Simulations/SimFrapInCircleGeometry.hoc") load_file("Simulations/SimFrapLine.hoc") load_file("Simulations/SimSpatialVoltageDistribution...
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: AdEx GIF model : This implementation is for the equations in: : Naud R, Marcille N, Clopath C, Gerstner W. Firing patterns in the adaptive : exponential integrate-and-fire model. Biol Cybern. 2008 Nov;99(4-5):335-47. doi: : 10.1007/s00422-008-0264-7. Epub 2008 Nov 15. PubMed PMID: 19011922; PubMed : Central PMCID: ...
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TITLE pyrna.mod DCN pyramidal cell model sodium channel COMMENT Revised version of DCN Pyramidal cell model sodium channel This model implements part of a Dorsal Cochlear Nucleus Pyramidal point cell based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis This...
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: ATM GIF model : This implementation the adaptive theshold model (ATM) is for the equations in: : Fontaine, B., Benichourx, V., Joris, P.X., and Brette, R. Prediciting : spike timing in hhigy synchronous auditory neurons at different sound : levels. J. Neurophysiol. 110: 1672-1688, 2013. : Which in turn is based on:...
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load_file("nrngui.hoc") objref input, NetInput NumberLeaves=12 // Number of leaves per stalk //objref gsec[1000000] // NUmber of sections NumberListSoma=0 // SizeTotal is a total number of geometrical objects SizeTotal=NumberDendrites*NumberLeaves+1+NumberListSoma*NumberLeaves //********************************** ...
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TITLE jsrnaf.mod VCN Na conductance, fast model COMMENT gnaf is the modified form used in his 1993 M.S. thesis (as in Rothman et al., J. Neurophysiol. 70:2562, 1993), with rapid recovery from inactivation for potentials below rest. Implementation by Paul B. Manis, April and Sept, 1999. ENDCOMMENT UNITS { (mA) = (mi...
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NEURON
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TITLE ihpyr_adj.mod DCN pyramidal cell model H-current COMMENT This model is part a Dorsal Cochlear Nucleus Pyramidal point cell based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis Added export of start states for some variables to do perturbation tests The...
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NEURON
2,991
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TITLE kif.mod DCN pyramidal cell model fast transient current COMMENT This model implements a fast transient potassium current from Dorsal Cochlear Nucleus Pyramidal cells based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) -- 15 Jan 1999 P. Manis 2/10/02. P. Manis. ...
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TITLE detailed model of Glycine receptors COMMENT ----------------------------------------------------------------------------- Kinetic model of Glycine-A receptors ==================================== C -- C1 -- C2 -- O1 | | D1 -- D2 -- D3 ----------------------------------------...
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TITLE klt.mod The low threshold conductance of cochlear nucleus neurons COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements the low threshold potassium current found in several brainstem nuclei of the auditory system, including the spherical and globular bushy ce...
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COMMENT Updated Exp2Syn synapse with Mg-blocked nmda channel. Defaul values of parameters (time constants etc) set to match synaptic channels in striatal medium spiny neurons (Du et al., 2017; Chapman et al., 2003; Ding et al., 2008). Robert . Lindroos @ ki . se original comment: ________________ Two state kinetic ...
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TITLE kht.mod The high threshold conductance of cochlear nucleus neurons COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements the high threshold potassium current found in several brainstem nuclei of the auditory system, including the spherical and globular bushy ...
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NEURON
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TITLE Model of glycine receptors COMMENT ----------------------------------------------------------------------------- Kinetic model of glycine receptors =============================== 6-state gating model with 2 open states provide dual exponential response. O1 | ...
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TITLE HVA L-type calcium current (Cav1.2) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { THREADSAFE SUFFIX cal12 USEION ca READ cai, cao WRITE ica VALENCE 2 ...
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COMMENT Updated Exp2Syn synapse with Mg-blocked nmda channel. Defaul values of parameters (time constants etc) set to match synaptic channels in striatal medium spiny neurons (Du et al., 2017; Chapman et al., 2003; Ding et al., 2008). Robert . Lindroos @ ki . se original comment: ________________ Two state kinetic ...
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NEURON
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TITLE detailed model of Glycine receptors COMMENT ----------------------------------------------------------------------------- Kinetic model of Glycine-A receptors ==================================== C -- C1 -- C2 | | O1 O2 ---------------------------------------------------...
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// UI objref vBoxCadifusParams // Inits Calcium parameters. proc initCaParams() { DCa_cadifus = 0.15 TBufs_cadifus = 0.07 kfs_cadifus = 1000 KDs_cadifus = 10 TBufm_cadifus = 0.0075 kfm_cadifus = 1000 KDm_cadifus = 0.24 DBufm_cadifus = 0.05 cath_cadifus = 2e-005 gamma_cadifus = 2...
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TITLE detailed model of Glycine receptors COMMENT ----------------------------------------------------------------------------- Kinetic model of Glycine-A receptors: Pascal Legendre (Mauthner Cell) ==================================== C0--C1--C2--O1 | C3--O2 -------------------...
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COMMENT The model of Glutamate transporter. is based on two papers, from the paper 1. Zhang Z1, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, Grewer C. Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18025-30...
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TITLE LVA L-type calcium current (Cav1.3) UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) (molar) = (1/liter) (mM) = (millimolar) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { THREADSAFE SUFFIX cal13 USEION ca READ cai, cao WRITE ica VALENCE 2 ...
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TITLE NMDA receptor--one of the two input stimulation of our model : This mechanism is taken from the Neuron data base "exp2syn.mod" : The original comment are below between "COMMENT" and "ENDCOMMENT". : : Our modifications: : : 1.We added a single receptor conductance factor: "g_max=0.000045 (uS)". : An event of...
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// Number of Gaps distributed in the model astrocyte GapJunctionMaxNumber = NumberDendrites+1 objref gaps[GapJunctionMaxNumber] NumberListSoma = 1 // Total number of geometrical objects // NumberDendrites is a Number in the file of 3D reconstruction SizeTotal = (NumberDendrites+NumberListSoma)*NumberLeaves+1 // Leaves...
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// UI objref vBoxConstantStimulations // Stimulators objref electricalStim, current, synapticInput, NetInput // Electrical stimulation // This set of parameters define the single synaptic input. // The user can add here as much as possible. // $1 - Current delay // $2 - Current duration // $3 - Current amplitude // $4...
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// This file is original file from Neuron Data base // https://senselab.med.yale.edu // Accession:97985 //A 3-d reconstructed neuron model can be simulated in parallel on a dozen or so processors and experience almost linear speedup. Network models can be simulated when there are more processors than cells. //Referenc...
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: Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized and efficient : axonal acti...
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TITLE ihsgc-apical.mod - Spiral Ganglion Cell Ih current for Apical Region COMMENT Ih for Spiral ganglion cells. Kinetcs are based on average fits to mouse SGCs, This model is for just the apical cell group. Data used to establish the kinetic parameters were collected by Qing Liu and Robin Davis (Rutgers). Data were t...
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: : ichanWT2005.mod : : Alan Goldin Lab, University of California, Irvine : Jay Lickfett - Last Modified: 6 July 2005 : : This file is the Nav1.1 wild-type channel model described in: : : Barela et al. An Epilepsy Mutation in the Sodium Channel SCN1A That Decreases : Channel Excitability. J. Neurosci. 26(1...
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objref NetInput1[TotalNUmberGapJunction+2] // *********** Calcium stimulation sets******************************************* objref r, inputSt[TotalNUmberGapJunction+2], StimTrigger[TotalNUmberGapJunction+2] r = new Random(Initseed) // $1 BasicStimulus, // $2 Interval, // $3 ECaresting, // $4 Tau1St, // $5 ...
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TITLE ihsgc-basalmiddle.mod - Spiral Ganglion Cell Ih current for basal and middle Regions COMMENT Ih for Spiral ganglion cells. Kinetcs are based on average fits to mouse SGCs, This model is for the basal and middle cell groups (averaged). Data used to establish the kinetic parameters were collected by Qing Liu and R...
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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TITLE Glutamatergic synapse with short-term plasticity NEURON { THREADSAFE POINT_PROCESS glutamate_sat RANGE tau1_ampa, tau2_ampa, tau1_nmda, tau2_nmda RANGE g_ampa, g_nmda, i_ampa, i_nmda, weight_ampa, weight_nmda RANGE e_ampa, e_nmda, g, i, q, mg RANGE tau, tauR, tauF, U, u0 RANGE ca_rati...
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TITLE Glutamatergic synapse with short-term plasticity NEURON { THREADSAFE POINT_PROCESS tmGlut RANGE tau1_ampa, tau2_ampa, tau1_nmda, tau2_nmda RANGE g_ampa, g_nmda, i_ampa, i_nmda, nmda_ratio RANGE e_ampa, e_nmda, g, i, q, mg RANGE tau, tauR, tauF, U, u0 RANGE ca_ratio_ampa, ca_ratio_nmda...
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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TITLE Calcium ion accumulation and diffusion with pump : The internal coordinate system is set up in PROCEDURE coord_cadifus() : and must be executed before computing the concentrations. : The scale factors set up in this procedure do not have to be recomputed : when diam or DFree are changed. : The amount of calcium i...
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: Nav1.2 (SCN2A) - mutated channel : : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports l...
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: Nav1.2 (SCN2A) - mutated channel : : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports l...
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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: Nav1.6 (SCN8A) : : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized ...
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: Nav1.2 (SCN2A) : : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized ...
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: Nav1.2 (SCN2A) : : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized ...
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TITLE Rsg sodium channel : Resurgent sodium channel (with blocking particle) : with updated kinetic parameters from Raman and Bean NEURON { SUFFIX naRsg USEION na READ ena WRITE ina RANGE gna, gbar } UNITS { (mV) = (millivolt) (S) = (siemens) } PARAMETER { gbar = .015 (S/cm2) : kinetic parameters Co...
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TITLE nacn.mod A sodium conductance for a ventral cochlear nucleus neuron model COMMENT NEURON implementation of Jason Rothman's measurements of VCN conductances. This file implements a modified version of the average brain sodium current used in the Rothman and Manis 2003 models. The model differs from th...
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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NEURON
4,418
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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TITLE simple AMPA receptors COMMENT ----------------------------------------------------------------------------- Simple model for glutamate AMPA receptors ========================================= - FIRST-ORDER KINETICS, FIT TO WHOLE-CELL RECORDINGS Whole-cell recorded postsynaptic currents mediated by AMP...
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// Calcium Gap Junctions objref gapsca[SizeTotal*2] // Random objref randomStretch objref randomLeavesDiameters randomLeavesDiameters = new Random() // Sets rresistance and potential to gaps. // $1 - Gap resistance // $2 - Potential proc res_gap() { for i = 2, NumberDendrites-2 { gaps[i].r = $1 ga...
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: Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized and efficient : axonal action...