id stringlengths 11 14 | sentence1 stringlengths 21 192 | sentence2 stringlengths 55 47.4k | label stringclasses 2
values |
|---|---|---|---|
converted_381 | Is cadasil syndrome a hereditary disease? | CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast... | yes |
converted_4032 | Is G3BP1 found in stress granules? | RAS GTPase-activating protein-binding protein (G3BP1) is an RNA-binding protein that is essential for assembling stress granules. , Within SGs, single-molecule localization microscopy revealed distributed hotspots of immobilized G3BP1 and IMP1 that reflect the presence of relatively immobile nanometer-sized nanocores.,... | yes |
converted_169 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs., ... | no |
converted_2571 | Can gas vesicles be detected by ultrasound? | Gas vesicles-genetically encoded protein nanostructures isolated from buoyant photosynthetic microbes-have recently been identified as nanoscale reporters for ultrasound., Here, we demonstrate that genetic engineering of gas vesicles results in nanostructures with new mechanical, acoustic, surface, and functional prope... | yes |
converted_2784 | Is there any association between the human gut microbiome and depression? | Moreover, recent findings are suggestive of the possibility that dysregulation of the enteric microbiota (i.e., dysbiosis) and associated bacterial translocation across the intestinal epithelium may be involved in the pathophysiology of stress-related psychiatric disorders, particularly depression.[SEP]Definitions: hum... | yes |
converted_2877 | Can enasidenib be used for the treatment of acute myeloid leukemia? | In August 2017, the United States Federal Drug Administration (FDA) approved enasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory acute myelogenous leukemia (AML) with an IDH2 mutation. [SEP]Definitions: AML defined as following: Clonal expansion of myeloid blasts in bone marrow, blood, and other ... | yes |
converted_3791 | Do nematodes contain a CTCF gene? | Our findings show that CTCF and possibly chromatin insulation are present in basal nematodes. We suggest that the insulator protein CTCF has been secondarily lost in derived nematodes like C. elegans., The most highly enriched motif (LM1) corresponds to the X-box motif known from yeast and nematode. , show that three ... | yes |
converted_1695 | Is calcium overload involved in the development of diabetic cardiomyopathy? | High-glucose treatment resulted in increased intracellular calcium ([Ca2+]i) which was mobilized to the mitochondria. Concomitant intra-mitochondrial calcium ([Ca2+]m) increase resulted in enhanced reactive oxygen and nitrogen species generation. These events led to mitochondrial dysfunction and apoptosis., The novel f... | yes |
converted_3736 | Is αCGRP a member of the CGRP family? | αCGRP, another amyloidogenic member of the CGRP family., Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP f... | yes |
converted_188 | Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring, These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1, Here we show that three proteins requi... | yes |
converted_4178 | Do bacteria release extracellular vesicles? | Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites., Knowledge of the structure, molecular cargo and function of bacterial extracellular vesicles (BEVs) is primarily obtained from bacteria cultured i... | yes |
converted_523 | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC., Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass ... | yes |
converted_3248 | Is endotrophin derived from collagen? | endotrophin production from type IV collagen, High levels of COL6A3 and its cleaved product, endotrophin (ETP), Endotrophin is released from COL VI[SEP]Definitions: COL6A3 defined as following: Collagen alpha-3(VI) chain (3177 aa, ~344 kDa) is encoded by the human COL6A3 gene. This protein plays a role in extracellular... | yes |
converted_2129 | Is diphosphatidylglycerol (cardiolipin) a phospholipid of the mitochondrial membranes? | A unique organelle for studying membrane biochemistry is the mitochondrion whose functionality depends on a coordinated supply of proteins and lipids. Mitochondria are capable of synthesizing several lipids autonomously such as phosphatidylglycerol, cardiolipin and in part phosphatidylethanolamine, phosphatidic acid an... | yes |
converted_1467 | Are BRAF mutations common in melanoma? | patients with BRAF-mutant melanoma., BRAF-mutated melanoma , The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in part... | yes |
converted_2590 | Does temsirolimus improve survival of glioblastoma patients? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_1414 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
converted_2408 | Was saracatinib being considered as a treatment for Alzheimer's disease in November 2017? | A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease., Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treat... | yes |
converted_1283 | Is factor XI deficient in Hemophilia C? | Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic,, Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C), rare case of an acute cerebral aneurysm rupture in a patient with a known factor XI defic... | yes |
converted_4100 | Are synonymous sites in primates and rodents functionally constrained? | To resolve this contradiction between expectations and observations, we used processed pseudogenes as a model for strict neutral evolution, and estimated selective constraint on synonymous sites using the rate of substitution at pseudosynonymous and pseudononsynonymous sites in pseudogenes as the neutral expectation. A... | no |
converted_162 | Is there an increased risk for cancer in Dyskeratosis Congenita? | People with DC are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis, Clinical progression of the disease can lead to aplastic anemi... | yes |
converted_985 | Is JTV519 (K201) a potential drug for the prevention of arrhythmias? | We compared the suppressive effect of K201 (JTV519), a multiple-channel blocker and cardiac ryanodine receptor-calcium release channel (RyR2) stabilizer, with that of diltiazem, a Ca(2+ )channel blocker, in 2 studies of isoproterenol-induced (n = 30) and ischemic-reperfusion-induced VAs (n = 38) in rats. , After admini... | yes |
converted_1530 | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels., The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes., at hyperthyroid p... | no |
converted_4578 | Is the protein HOXA11 associated with endometrial disease? | Both CD10 and HOXA11 have been implicated in regulation of endometrial homeostasis., Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors., The combination of HOXA11 and CD10 expression profiles provides a useful tool to identify ectopic endometrial tissue and for distinguish... | yes |
converted_2141 | Is osteocrin expressed exclusively in the bone? | Evolution of Osteocrin as an activity-regulated factor in the primate brain., Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons., Osteocrin (Ostn) is a recentl... | no |
converted_319 | Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. I, In addition, miR-21, -24, -133, -210, -494, and -499 appear to protect myocytes against I/R-induced apoptosis, whereas mi... | yes |
converted_4711 | Can METTL3 methylate long noncoding RNAs? | METTL3-Mediated lncRNA m6A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein., This study aimed to explore the regulatory mechanism of methyltransferase3 (METTL3) -mediated long non-coding RNA (lncRNA) N6-methyladenosine (m6A) modification in the osteogenic... | yes |
converted_1775 | Is exon skipping correlated with exon circularization? | Exon Skipping Is Correlated with Exon Circularization, We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome, Exon Skipping Is Correlated with Exon Circularization., We find that circularization of ... | yes |
converted_703 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. , The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 113... | yes |
converted_677 | Are there any urine biomarkers for bladder cancer diagnosis? | CONCLUSIONS: Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer, Novel promising markers are in v... | yes |
converted_3174 | Was stelara developed by Amgen? | NICE does not specifically recommend switching from one biologic to another, and only ustekinumab (UST; STELARA®, Janssen Pharmaceuticals, Inc., Horsham, PA, USA) is recommended after anti-tumour necrosis factor failure.[SEP]Definitions: Janssen Pharmaceuticals defined as following: A pharmaceutical company providing m... | no |
converted_2357 | Is Kummell’s disease an avascular necrosis of the vertebral body? | Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis., Kumme... | yes |
converted_62 | Is pregnancy an additional risk during during H1N1 infection? | H1N1 influenza in pregnancy can be associated with severe complications, This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09., Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection., Pregnant women are at increased risk for complica... | yes |
converted_4546 | Is METTL1 overexpression associated with better patient survival? | Here we find METTL1 is frequently amplified and overexpressed in cancers and is associated with poor patient survival. METTL1 depletion causes decreased abundance of m7G-modified tRNAs and altered cell cycle and inhibits oncogenicity. Conversely, METTL1 overexpression induces oncogenic cell transformation and cancer. ... | no |
converted_691 | Do lincRNAs play a role in human cancer? | Long non-coding RNA H19 increases bladder cancer metastasis, These data suggest that upregulated H19 enhances bladder cancer metastasis by associating with EZH2 and inhibiting E-cad expression, lncRNA H19 is essential for human tumor growth, Previous reports have demonstrated that HOTAIR associates with chromatin modif... | yes |
converted_1536 | Are OATP1B1 and OATP1B3 associated with bilirubin transport? | OATP1B1 and OATP1B3-mediated transport of bilirubin was confirmed and inhibition was determined for atazanavir, rifampicin, indinavir, amprenavir, cyclosporine, rifamycin SV and saquinavir. , Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bi... | yes |
converted_1274 | Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity? | Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics are stem cell loss, causing progressive bone marrow failure and sterilit... | yes |
converted_3984 | Should minocycline be used for mild Alzheimer disease? | Conclusions and Relevance: Minocycline did not delay the progress of cognitive or functional impairment in people with mild AD during a 2-year period. [SEP]Definitions: Minocycline defined as following: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective agai... | no |
converted_3183 | Are protamines ubiquitously expressed? | Protamines are nuclear proteins which are specifically expressed in haploid male germ cells.[SEP]Definitions: Protamines defined as following: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino ... | no |
converted_3510 | Are there interactions between short and long noncoding RNAs? | It is now evident that noncoding RNAs play key roles in regulatory networks determining cell fate and behavior, in a myriad of different conditions, and across all species. Among these noncoding RNAs are short RNAs, such as MicroRNAs, snoRNAs, and Piwi-interacting RNAs, and the functions of those are relatively well un... | yes |
converted_3383 | AhR ligands are attractive drug targets for pharmaceutical development due to their induction of Cyp1a1, yes or no? | Based on our review of the data, there is little evidence to support the indiscriminate exclusion of AhR activators/Cyp1a1 inducers from early drug developmental pipelines. We also found no evidence that short-term treatment with RMAhRLs produce "dioxin-like toxicity", However, recent discoveries of new AhR ligands wi... | yes |
converted_2176 | Is dexamethasone recommended for treatment of intracerebral hemorrhage? | Dexamethasone and other glucocorticoids should be avoided. , During the third interim analysis, the death rate at the 21st day was identical in the two groups (dexamethasone vs. placebo, 21 of 46 vs. 21 of 47; chi-square = 0.01, P = 0.93). In contrast, the rate of complications (mostly infections and complications of d... | no |
converted_2565 | Does armodafinil improve fatigue of glioma patients? | CONCLUSIONS: While treatment was well-tolerated, an 8-week course of armodafinil did not improve fatigue or QOL in glioma patients undergoing RT in this pilot study. , We evaluated whether armodafinil, a wakefulness-promoting medication, improves fatigue in glioma patients undergoing RT., Armodafinil did not significan... | no |
converted_2787 | Is cohesin linked to myeloid differentiation? | Consistent with a role for inflammatory signals in promoting myeloid differentiation of hematopoietic stem and progenitor cells (HPSCs), cohesin mutations in HSPCs led to reduced inflammatory gene expression and increased resistance to differentiation-inducing inflammatory stimuli. These findings uncover an unexpected ... | yes |
converted_3007 | Can mitochondria be inherited by both parents in humans? | Biparental Inheritance of Mitochondrial DNA in Humans., Although there has been considerable debate about whether paternal mitochondrial DNA (mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally believed that mitochondria and mtDNA are exclusively maternally inherited in humans. Here, we... | yes |
converted_3545 | Does the BRAFV600E mutation have an effect on clinical response to radioiodine therapy? | Preclinical studies showed that BRAF mutation significantly reduced radioiodine uptake and decreased the sensitivity to radioactive iodine (RAI) therapy., The status of BRAF mutation may not affect the clinical response to RAI therapy for patients with PTMC with intermediate-risk to high-risk features. More trials exam... | yes |
converted_2136 | Is Cri Du Chat associated with an expansion of a repeat with in the gene found on chromosome 5? | Cri-du-chat syndrome is a chromosomal disorder caused by a deletion of the short arm of chromosome 5, The typical cri du chat syndrome, due to 5p15.2 deletion, includes severe intellectual disability, facial dysmorphisms, neonatal hypotonia and pre- and post-natal growth retardation, whereas more distal deletions in 5p... | no |
converted_3406 | Does xaliproden improve prognosis of amyotrophic lateral sclerosis? | Treatment for crampsThere is evidence (13 RCTs, N = 4012) that for the treatment of cramps in MND, compared to placebo:- memantine and tetrahydrocannabinol (THC) are probably ineffective (moderate-quality evidence);- vitamin E may have little or no effect (low-quality evidence); and- the effects of L-threonine, gabapen... | no |
converted_3584 | Can PRL3-zumab inhibit PRL3+ cancer cells in vitro and in vivo? | Here we show that PRL3-zumab specifically inhibits PRL3+ cancer cells in vivo, but not in vitro.[SEP]Definitions: PRL3 defined as following: Human PTP4A3 wild-type allele is located in the vicinity of 8q24.3 and is approximately 40 kb in length. This allele, which encodes protein tyrosine phosphatase type IVA 3 protein... | no |
converted_2286 | Does a tonsillectomy affect the patient's voice? | Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), voice change (61 vs 19%, P = .005), and burns to lips and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of tonsillectomy as good or very good (P = .017)., Some patients complaint for dry... | yes |
converted_1444 | Is arimoclomol a co-inducer of the heat shock response? | Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique properties as co-inducers of heat shock protein expression, but only under conditions of cellular stress. , In this review we summarize the evidence for the neuroprotective effects of enhanced heat shock protein expression by Arimoclomol ... | yes |
converted_1548 | Is the gene SLC6A2 associated with orthostatic intolerance? | Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. , Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intol... | yes |
converted_366 | Is there an association between TERT promoter mutation and survival of glioblastoma patients? | Glioblastoma patients with TERT mutations showed a shorter survival than those without TERT mutations in univariate analysis (median, 9.3 vs. 10.5 months; P = 0.015) and multivariate analysis after adjusting for age and gender (HR 1.38, 95 % CI 1.01-1.88, P = 0.041). However, TERT mutations had no significant impact on... | yes |
converted_2096 | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. , Cryptococcus is a ubiquitous fungus and is k... | no |
converted_4566 | Is Otolin-1 a matrix protein? | otoconia matrix protein, otolin-1, Otolin-1 is a collagen-like protein expressed in the inner ear of vertebrates. , Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1, binds to otolin-1 and forming matrix protein architectures[... | yes |
converted_2848 | Is inositol effective for trichotillomania? | Patients assigned to inositol failed to show significantly greater reductions on primary or secondary outcomes measures compared with placebo (all P>0.05)., This is the first study assessing the efficacy of inositol in the treatment of trichotillomania, but found no differences in symptom reductions between inositol an... | no |
converted_4119 | Can propofol cause green urine? | Reasons for discontinuing propofol are signs of rhabdomyolysis (92.9%), green urine, elevated liver enzymes (71.4% each) and elevated triglycerides (57.1%)., Propofol-Induced Green Urine in a Patient with Refractory Status Epilepticus., We present the case of a 52-year-old man, who developed green urine following propo... | yes |
converted_3539 | Are gut microbiota profiles altered by irradiation? | Specific Members of the Gut Microbiota are Reliable Biomarkers of Irradiation Intensity and Lethality in Large Animal Models of Human Health., Irradiation profoundly impacted gut microbiota profiles in both animals., Our findings suggest that gut symbiont-based probiotics can be used as agents for reversing radiation-i... | yes |
converted_1103 | Is miR-21 related to carcinogenesis? | miR-21* and miR-203 were significantly dysregulated (P < 0.05) in PTC tissues with BRAFV600E., Expressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation., Levels of miRNA-21 (miR-21) and miR-106a in gastric cancer tissues were significantly higher compared with the levels i... | yes |
converted_2259 | Does TUC.338 inhibit colorectal cancer? | TUC.338 promotes invasion and metastasis in colorectal cancer., Until now, the role of TUC.338 in colorectal cancers remains undefined. This study revealed that TUC.338 is significantly up-regulated in colorectal cancers (CRC) tissue and CRC cell lines, and the up-regulated TUC.338 is associated with lymph node metasta... | no |
converted_646 | Are chromomethylases present in animal genomes? | Many plant, animal, and fungal genomes contain cytosine DNA methylation in asymmetric sequence contexts (CpHpH, H = A, T, C)., However, at the SUPERMAN locus, asymmetric methylation was only completely abolished in drm1 drm2 chromomethylase 3 (cmt3) triple mutant plants., Although neither the drm1 drm2 double mutants n... | no |
converted_4001 | Should nerinetide be used for treatment of ischaemic stroke? | 337 (61·4%) of 549 patients with nerinetide and 329 (59·2%) of 556 with placebo achieved an mRS score of 0-2 at 90 days (adjusted risk ratio 1·04, 95% CI 0·96-1·14; p=0·35). Secondary outcomes were similar between groups., INTERPRETATION: Nerinetide did not improve the proportion of patients achieving good clinical out... | no |
converted_2308 | Is there an RNAi drug being developed to treat amyloidosis? | Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality.[SEP]Definitions: amyloidosis defined as following: A group of sporadic, familial and/or inh... | yes |
converted_3037 | Are there graph kernel libraries available implemented in JAVA? | graphkernels: R and Python packages for graph comparison., Measuring the similarity of graphs is a fundamental step in the analysis of graph-structured data, which is omnipresent in computational biology. Graph kernels have been proposed as a powerful and efficient approach to this problem of graph comparison. Here we ... | no |
converted_528 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. , The vein graft s... | yes |
converted_4434 | Is Satb1 a transcription factor? | Special AT-rich sequence binding protein-1 (SATB1) is localized to the nucleus and remodels chromatin structure in T cells, chromatin organizers SATB2 and SATB1 , transcription factor complexes. These MYB complexes assemble aberrantly with LYL1, E2A, C/EBP family members, LMO2, and SATB1. , Staining for the transcripti... | yes |
converted_4052 | Is SLIC-CAGE used for quantification of translation? | Transcription Start Site Mapping Using Super-low Input Carrier-CAGE., SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA., Cap analysis of gene expression (CAGE) is a methodology for genome-wide quantitative mapping of mRNA 5' ends to precisely capture transcription start sit... | no |
converted_4277 | Αre plants from the genus Strychnos the original source of curare? | Poisons are widespread in plants and animals and humankind has often tried to turn them to its own advantage. Owing to their poisonous properties, some species of Strychnos genus have been employed mainly in hunting and fishing, as an adjunct to weapons used not only in the search of food and clothes, but also for prev... | yes |
converted_4485 | Is nerinetide effective for ischaemic stroke? | 337 (61·4%) of 549 patients with nerinetide and 329 (59·2%) of 556 with placebo achieved an mRS score of 0-2 at 90 days (adjusted risk ratio 1·04, 95% CI 0·96-1·14; p=0·35). Secondary outcomes were similar between groups. , INTERPRETATION: Nerinetide did not improve the proportion of patients achieving good clinical ou... | no |
converted_84 | Is valproic acid effective for glioblastoma treatment? | A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma., PURPOSE: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in precl... | yes |
converted_4416 | Is periampullary carcinoma (PAC) a relatively rare genitourinary malignancy | Pancreaticobiliary subtype of Periampullary carcinoma (PAC) has a poor prognosis in comparison to the intestinal subtype., MUC1, CK20, and CDX2 immunohistochemical markers can sub-classify periampullary carcinomas into pancreaticobiliary, intestinal, and mixed subtypes., Pancreaticoduodenectomy (PD) is a complex surgic... | no |
converted_1766 | Is ocrelizumab effective for treatment of multiple sclerosis? | Advances made in immunomodulation are driving the progress being made in the treatment of MS. Ocrelizumab is the first treatment with positive results in the primarily progressive forms and tocilizumab, a drug product for rheumatoid arthritis, stands out as a potential candidate for the treatment of neuromyelitis opti... | yes |
converted_4258 | Can FTO promote pancreatic cancer development? | m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling., Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, in... | no |
converted_3834 | Does the use of bDMARDs during pregnancy impact neonatal development? | Exposure to bDMARDs during pregnancy does not seem to interfere with post-natal development up to infancy., Long-term follow-up data about newborns exposed to bDMARDs during pregnancy are however scarce. [SEP] | no |
converted_1871 | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. , Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit., AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility of the NEECHAM... | yes |
converted_1497 | Is depression associated with poor prognosis of brain tumor patients? | Before surgery 27 patients (35%) had BDI scores indicating the presence of depression. These scores were significantly higher in patients with a history of depression (p = 0.017) and in those with a lower functional outcome (p = 0.015)., A lower functional status (KPS score < or = 70) in patients was significantly asso... | yes |
converted_572 | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB, phosphorylation of PLN, at either Ser(16) by PKA , Activation of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB), which relieves the inhibitory effects of PLB... | yes |
converted_4450 | Is SOX10 expressed in melanoma cells? | Our study confirmed that SOX10 is an oncogene and activate Notch signaling pathway, which suggests the potential treatment for melanoma patients by target SOX10/Notch axis., The most commonly used melanocytic markers include S100, Melan-A, HMB45 and SOX10, melanocytic markers melan-A and SOX10 [SEP]Definitions: Melan-A... | yes |
converted_831 | Have 5q35 microdeletions been implicated in Sotos syndrome development? | Loss-of-function mutations of NSD1 and 5q35 microdeletions encompassing NSD1 are a major cause of Sotos syndrome (Sos), which is characterized by overgrowth, macrocephaly, characteristic facies, and variable intellectual disability (ID), We observed a novel 3.5 Mb 5q subtelomeric deletion in a 3-year-old girl with deve... | yes |
converted_4036 | Is colistin an antibiotic? | all antibiotics tested, apart from colistin, , Among the selected antibiotics, there were 12 fluoroquinolone antibiotics (tosufloxacin, levofloxacin, sparfloxacin, clinafloxacin, pazufloxacin, gatifloxacin, enrofloxacin, lomefloxacin, norfloxacin, fleroxacin, flumequine, ciprofloxacin), 15 beta-lactam or cephalosporin ... | yes |
converted_2117 | Is Lennox-Gastaut Syndrome usually diagnosed in older adults? | We studied 15 LGS patients (mean age ± 1 standard deviation [SD] = 28.7 ± 10.6 years) and 17 healthy controls (mean age ± 1 SD = 27.6 ± 6.6 years), children with Lennox-Gastaut syndrome, Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by mixed seizures, cognitive decline, and genera... | no |
converted_827 | Are histone deacetylase (HDAC) inhibitors good candidates to control metastasis of solid tumors? | JNJ-26481585 also fully inhibited the growth of C170HM2 colorectal liver metastases, whereas again 5-fluorouracil/Leucovorin showed modest activity., Although not meeting the RECIST response criteria for adequate single-agent activity, the observed tolerable toxicities and the potential for clinical benefit in terms of... | yes |
converted_3241 | Can Enlimomab improve stroke outcomes? | Treatment with a murine anti-ICAM-1 antibody (enlimomab) has been investigated in patients with acute ischemic stroke in the Enlimomab Acute Stroke Trial (EAST). Unfortunately, the case fatality rate in this trial was significantly higher in the enlimomab patient group than in the placebo group., The two clinical trial... | no |
converted_3445 | Does radiation for tinea capitis increases brain tumor risk? | Emphasis is placed on meningiomas resulting from childhood treatment for primary brain tumor or tinea capitis, exposure to dental x-rays, and exposure to atomic explosions in Hiroshima and Nagasaki. , It is well known that radiation can induce meningiomas. These tumors usually arise in patients with a history of low-do... | yes |
converted_1345 | Are DNA methylation maps applicable to the diagnosis of non-small-cell lung carcinomas? | Here we present a genome-wide DNA methylation analysis of NSCLC samples and paired lung tissues, where we combine MethylCap and next generation sequencing (MethylCap-seq) to provide comprehensive DNA methylation maps of the tumor and paired lung samples., Analysis of the MethylCap-seq data revealed a strong positive co... | yes |
converted_2145 | Are alterations in ultraconserved elements associated with colorectal adenocarcinoma? | Genetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma, Our results strongly suggest that several genetic variants in the UCEs may contribute to CRC susceptibility, individually and jointly, and that different genetic etiology may be involved in RCRC and LC... | yes |
converted_3829 | Is there any role of genotoxic pks + E. coli in cancer? | Mutational signature in colorectal cancer caused by genotoxic pks+, Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the p... | yes |
converted_4691 | Is HYDIN (Hydrocephalus-inducing protein homolog) an axonemal protein? | Hydin was recently identified as an axonemal protein; however, its function is as yet unknown., precise axonemal location of hydin, a protein that, when mutated, causes hydrocephalus, and defined a unique role for hydin in ciliary motility.[SEP]Definitions: protein defined as following: Protein; provides access to the ... | yes |
converted_1177 | Could bioprinting be used in regenerative medicine against bone disease? | Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. , It is expecte... | yes |
converted_187 | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO t... | yes |
converted_34 | Do mutations of AKT1 occur in meningiomas? | The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas., A mutation in PIK3CA or AKT1 was found in around 9 % of the cases., AKT1E17K mutations cluster with meningothelial an... | yes |
converted_4428 | Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila? | Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning., Here, using the dorsoventral patterning of the Drosophila melanogaster embryo as a model system, we provide evidence for the independence of chromatin organization and dorsoventral gene expression. We define tissue-sp... | no |
converted_1556 | Is CHEK2 involved in cell cycle control? | Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased., As CHEK2 is a cell-cycle master contro... | yes |
converted_384 | Is nintedanib effective for Idiopathic Pulmonary Fibrosis? | In this review, we present the positive results of recently published clinical trials regarding therapy for IPF, with emphasis on pirfenidone and nintedanib., Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis, In the Phase II TOMORROW trial, treatment with 150 mg of nintedanib twice d... | yes |
converted_1294 | Are optogenetics tools used in the study and treatment of epilepsy? | The emerging revolutionary technique of optogenetics enables manipulation of the activity of specific neuronal populations in vivo with exquisite spatiotemporal resolution using light. We used optogenetic approaches to test the role of hippocampal excitatory neurons in the lithium-pilocarpine model of acute elicited se... | yes |
converted_3255 | Can Daptacel be used instead of IPOL? | Our goal was to compare the safety and immunogenicity of a combination vaccine (DTaP(5)-IPV-Hib; Pentacel) with that of its separately administered, US-licensed equivalent vaccines (diphtheria, tetanus, 5-component acellular pertussis vaccine [DTaP(5); Daptacel], inactivated poliovirus vaccine [IPV; IPOL], and Haemophi... | no |
converted_3930 | Has the olive tree pollen proteome been studied? | Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome. [SEP] | yes |
converted_216 | Are there any DNMT3 proteins present in plants? | De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3., Here we describe DNA methyltransferase genes from both Arabidopsis and maize that show a high level of sequence similarity to Dnmt3, suggesting that they encode plant ... | yes |
converted_3231 | Is CD63 an exosomal marker? | f exosome marker proteins (e.g., CD63, Alix) , CD63 levels and acetylcholinesterase (AChE) activity were used as markers of exosome,, The results demonstrated these exosomes all expressed CD9, CD63, CD81, Alix[SEP]Definitions: exosome defined as following: A type of extracellular vesicle, containing RNA and proteins,... | yes |
converted_211 | Is long QT syndrome a cause for sudden cardiac death in athletes? | A diversity of cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, aortic rupture due to Marfan syndrome, myocarditis, valvular disease and electrical disorders (Wolff-Parkinson-White syndrome, long QT syndrom... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.