id stringlengths 11 14 | sentence1 stringlengths 21 192 | sentence2 stringlengths 55 47.4k | label stringclasses 2
values |
|---|---|---|---|
converted_2662 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer., We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype.[SEP]Definiti... | no |
converted_3238 | Do tumour-associated macrophages have a prognostic role in gliomas? | Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double immunofluorescence., This is the first study to use automated quan... | yes |
converted_1082 | Are there any Decision support systems for chronic pain management ? | a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS), We based the DSS on the existing ATHENA-DSS, Use of this iterative process led to development of a multifunctional DSS, interactive decision dashboard... | yes |
converted_1421 | is there an increase in ultrasound comets after intense exercise? | Healthy athletes developed subclinical increase in pulmonary water content immediately after an Ironman race at sea level, as shown by the increased number of ULCs related to cardiac changes occurring during exercise., Increased EVLW is associated with estimated PCWP and indices of left ventricular systolic and diastol... | yes |
converted_2832 | Is durvalumab used for lung cancer treatment? | In the phase III PACIFIC trial consolidation with durvalumab, an anti-PDL-1 antibody, was associated with survival benefit in patients diagnosed with LA-NSCLC who responded to concurrent chemoradiotherapy., METHODS: An electronic literature search was performed of public databases (MEDLINE, Excerpta Medica dataBASE [E... | yes |
converted_1567 | Does low T3 negatively affect prognosis of patients after cardiac surgery? | ur findings suggest that the development of LCOS after congenital heart surgery is associated with decreased total and free T3, and increased IL-8 levels at 48 hours, and preoperative tT4 level is an independent predictor of LCOS., Low basal fT3 concentration can reliably predict the occurrence of postoperative AF in C... | yes |
converted_1383 | Is there an association between c-reactive protein concentrations and outcomes of subarachnoid hemorrhage patients? | Besides the baseline characteristics, daily interleukin-6 (IL-6), procalcitonin, C-reactive protein levels, and leukocyte counts were prospectively measured until day 14 after subarachnoid hemorrhage. Occurrence of infectious complications and application of therapeutic hypothermia were assessed as confounding factors.... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_2391 | Does the association of PARP1 and CTCF follow a circadian rhythm? | here we uncovered an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated domains (LADs)., Synchronization of the circadian rhythm by serum shock induces oscillations in PARP1-CTCF interactions, which is accompanied by oscillating recruitment of circadian loci to t... | yes |
converted_1206 | Is the SDHAF2 gene encoding a protein necessary for flavination of SDHA? | Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in SDHAF2, required for flavination of SDHA. , At present, these are RET proto-oncogene, von Hippel-Lindau disease tumor suppressor gene (VHL), neurofibromatosis type 1 tumor s... | yes |
converted_3284 | Do de novo truncating mutations in WASF1 cause cancer? | De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures., Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autis... | no |
converted_4419 | Is Sotatercept effective for Pulmonary Arterial Hypertension? | Sotatercept for the Treatment of Pulmonary Arterial Hypertension., CONCLUSIONS: Treatment with sotatercept resulted in a reduction in pulmonary vascular resistance in patients receiving background therapy for pulmonary arterial hypertension., Sotatercept for the Treatment of Pulmonary Arterial Hypertension, CONCLUSIONS... | yes |
converted_1071 | Are there any specific antidotes for dabigatran? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. ,... | no |
converted_1391 | Can RNASeq be used for the analysis of nascent transcripts? | Here, we utilize nascent RNA sequencing to document dosage compensation during transcriptional elongation., Here we show that RNA-seq can also be used for studying nascent RNAs undergoing transcription, Conversely, the nuclear fraction shows an enrichment of unprocessed RNA compared with total RNA-seq, making it suitab... | yes |
converted_2788 | Is pembrolizumab effective against Ewing's sarcoma? | None of the 13 patients with Ewing's sarcoma had an objective response. , Between March 13, 2015, and Feb 18, 2016, we enrolled 86 patients, 84 of whom received pembrolizumab (42 in each disease cohort) and 80 of whom were evaluable for response (40 in each disease cohort). [SEP]Definitions: Ewing's sarcoma defined as ... | no |
converted_2797 | Is selenocysteine an aminoacid? | Selenocysteine (Sec), a rare genetically encoded amino acid with unusual chemical properties, is of great interest for protein engineering., Selenocysteine (SeC) is a naturally available Se-containing amino acid that displays splendid anticancer activities against several human tumors. [SEP]Definitions: Selenocysteine ... | yes |
converted_404 | Is endostatin a proangiogenic factor? | endostatin (antiangiogenic factor, antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin, human endostatin (rh-endostatin), a potential antiangiogenic agent, , antiangiogenic PF4 and endostatin, Angiostatin and endostatin are endogenous inhibitors of angiogenesis with anticancer effects, the ant... | no |
converted_3897 | Can Freund's complete adjuvant induce arthritis? | complete Freund's adjuvant (CFA) induced RA, The RA model was established using Freund's complete adjuvant, , Rheumatoid arthritis (RA) was induced by Freund's Complete Adjuvant (FCA; 1 mg/0.1 ml paraffin oil), injected subcutaneously on days 0, 30 and 40, The rats were made arthritic using a subcutaneous injection wi... | yes |
converted_4560 | Is serotonin transported by platelets? | activated platelets, which carry peripheral serotonin,, Platelet serotonin response was measured by serotonin augmented platelet aggregation and platelet serotonin receptor density. , SERT was studied in the 1970s and 1980s using membrane vesicles isolated from blood platelets., platelet-dense granules contain neurotr... | yes |
converted_3707 | Has MLE4901 been tested in phase III clinical trials? | METHODS
This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 receptor antagonist (MLE4901) on menopausal hot flushes., Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double... | no |
converted_3384 | Does the chromatin remodeling complex, RSC target H2A.Z nucleosomes? | In contrast, the upstream nucleosome which covers the TATA box under repressed conditions is shifted approximately 50 bp further upstream by the ATP-dependent chromatin remodeler RSC upon activation. It is marked with the histone variant H2A.Z and H4K16 acetylation in active state, In RSC-depleted cells, NFRs shrink su... | yes |
converted_3978 | Can radiosurgery be used for the DNET tumors? | Salvage gamma knife radiosurgery in the management of dysembryoplastic neuroepithelial tumors: Long-term outcome in a single-institution case series., BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT/DNET) are rare epileptogenic tumors. Microsurgery remains the best treatment option, although case reports exist... | yes |
converted_1360 | Is triadin involved in cardiac function? | Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-m... | yes |
converted_308 | Is nucleosome eviction ATP-dependent? | ATP-dependent chromatin remodeling and nucleosome-depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, ATP-dependent nucleosome-remodeling factors endow chromatin with structural flexibility by promoting assembly or disruption of nucleosomes and the exchange of histone variants., remodel... | yes |
converted_2487 | Is there any role of Dlx1 and Dlx2 transcription factors in cortical interneurons? | The postnatal functions of the Dlx1&2 transcription factors in cortical interneurons (CINs) are unknown. Here, using conditional Dlx1, Dlx2, and Dlx1&2 knockouts (CKOs), we defined their roles in specific CINs. The CKOs had dendritic, synaptic, and survival defects, affecting even PV+ CINs. We provide evidence that DLX... | yes |
converted_3 | Are long non coding RNAs spliced? | Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths., For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced in some c... | yes |
converted_4463 | Is EuroQol 5-Dimension Health Assessment (EQ-5D) [a widely used, simple instrument that monitors the general health-related quality of life (HRQoL) in chronic disease] a 5 question assessment? | The 6-question EuroQol 5-Dimension Health Assessment (EQ-5D) is a widely used, simple instrument that monitors general health-related quality of life (HRQoL) in chronic disease. , OBJECTIVE: The 6-question EuroQol 5-Dimension Health Assessment (EQ-5D) is a widely used, simple instrument that monitors general health-rel... | no |
converted_900 | Are there plasma membrane receptors for thyroid hormones? | ntegrins are heterodimeric structural components of the plasma membrane whose ligands include a large number of extracellular matrix (ECM) proteins. , Recently, integrin αvβ3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrote... | yes |
converted_1278 | Is there evidence for de novo genesis of enhancers in vertebrates? | De novo genesis of enhancers in vertebrates., Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhan... | yes |
converted_3899 | Is erabutoxin b usually found in plants? | The variants are the curaremimetic toxin alpha from Naja nigricollis and erabutoxin a or b from Laticauda semifasciata, The three-dimensional structure of erabutoxin b, a short-chain neurotoxic peptide purified from the venom of the sea snake Laticauda semifasciata, , THe characteristic feature of the crystal structure... | no |
converted_1223 | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. , Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associati... | yes |
converted_1491 | Is there any research that relates the function of Notch Signaling with Alzheimer Disease? | RIP regulates signaling pathways by abrogating or releasing signaling molecules. Since the discovery, already >15 years ago, of its catalytic component, presenilin, and even much earlier with the identification of amyloid precursor protein as its first substrate, γ-secretase has been commonly associated with Alzheimer'... | yes |
converted_3035 | Is Lasmiditan effective for migraine? | Amongst the ditans, lasmiditan: (i) fails to constrict human coronary arteries; and (ii) is effective for the acute treatment of migraine in preliminary Phase III clinical trials., Although ongoing phase III clinical trials are needed to confirm its efficacy and safety, lasmiditan might offer an alternative to treat ac... | yes |
converted_3856 | Does an antiphlogistic promotes inflammation? | The therapeutic effect of olipiphate was demonstrated for chronic inflammation of advanced arthritis and concanavalin A-related acute edema. The best systemic effect was obtained with 50 mg/kg, symptomatic--100 mg/kg. Skin wounds treated with 5% olipiphate (26 + 2) healed faster than those treated with 2% solcoseryl (3... | no |
converted_1343 | Are conserved noncoding elements associated with the evolution of animal body plans? | Here, we discuss the evidence that CNEs are part of the core gene regulatory networks (GRNs) that specify alternative animal body plans. The major animal groups arose>550 million years ago. We propose that the cis-regulatory inputs identified by CNEs arose during the "re-wiring" of regulatory interactions that occurred... | yes |
converted_3046 | Does Rhamnose have any effect on aging? | The monosaccharide analysis showed that rhamnose (Rha) and glucose (Glu) may play vital roles in maintaining the antioxidant and anti-aging activities. , Some of these mechanisms will be reviewed as well as the capacity of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP) to counteract several of the... | yes |
converted_3339 | Can MVA85A confer immunity against smallpox? | We assessed the safety, immunogenicity, and efficacy of a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults infected with HIV-1., Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised,... | no |
converted_2670 | The TRPM2 gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for o... | no |
converted_3402 | Does promoter shape vary across populations? | Promoter shape varies across populations and affects promoter evolution and expression noise., Animal promoters initiate transcription either at precise positions (narrow promoters) or dispersed regions (broad promoters), a distinction referred to as promoter shape. Although highly conserved, the functional properties ... | yes |
converted_2665 | Is Lysyl oxidase crosslinking collagen? | Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. , Lysyl oxidase-like 1, a crosslinking enzyme implicated in collagen and elastin biogenesis, LOXL2 mediates collagen crosslinking, The same was true for assaying lysyl ox... | yes |
converted_3754 | Glucoraphanin from broccoli can help reduce obesity , yes or no? | Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance., A recent study demonstrated that glucoraphanin, a precursor of the Nrf2 activator sulforaphane, ameliorates obesity by enhancing energy expenditure and browning of white adipose tissue, and attenuates obesity... | yes |
converted_2801 | Is ibudilast effective for multiple sclerosis? | Ibudilast slowed brain atrophy in PPMS and SPMS patients in a multicenter phase 2b study., Ibudilast inhibits several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and toll-like receptor 4 and can cross the blood-brain barrier, with potential salutary effects in progressive multiple scl... | yes |
converted_3527 | Does metformin alleviate atherosclerosis? | Metformin and rosiglitazone both improve glycemic control in type 2 diabetes mellitus, however may possess different anti-inflammatory and anti-atherosclerotic properties. , Demonstrating antiatherothrombotic properties of dipeptidyl peptidase-4 inhibitors on proven markers is of substantial clinical significance. Coup... | yes |
converted_4686 | Is retinol binding protein 4 an adipokine? | Systematic Quantification of Neurotrophic Adipokines RBP4, PEDF, and Clusterin in Human Cerebrospinal Fluid and Serum., Retinol-binding protein 4 (RBP4) is a prominent adipokine i, Fetuin-A and retinol-binding protein 4 (RBP4) are secreted as both hepatokine and adipokine. [SEP]Definitions: adipokine defined as followi... | yes |
converted_3024 | Is deletion at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., We found that loss at 6q24.2-26 was significantly associated with the cluster of longer survival independently from other confounding factors (HR = 0.06, 95%CI = 0.01-0.43, Padj = 0.005). The prognostic value of thi... | yes |
converted_1059 | Are piRNAs involved in gene silencing? | In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown., Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcri... | yes |
converted_1285 | Are EDNRB mutations involved in the development of Hirschsprung disease? | QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations, As reported previously, when the same null mutation of the Ednrb gene, Ednrb(sl), was introgressed into the F344 strain, almost 60% of F344-Ednrb(sl/sl) pups did not show any symptoms of agan... | yes |
converted_1800 | Does Vitamin D induce autophagy? | 1,25(OH)2D treatment was accompanied by autophagy activation , Autophagy signaling pathway was regulated by vitamin D3, vitamin D induces autophagy, Vitamin D shows promise for the prevention and amelioration of pathologic responses in IBD, an effect that is mediated, at least in part, by the induction and modulation ... | yes |
converted_2265 | Does echinacea increase anaphylaxis risk? | Chicoric acid (dicaffeoyl-tartaric acid), is a natural phenolic compound found in a number of plants, such as chicory (Cichorium intybus) and Echinacea (Echinacea purpurea), which possesses antioxidant, anti-inflammatory, antiviral, and analgesic activities. Although these biological effects of chicoric acid have been ... | yes |
converted_836 | Is there any functional association during viral replication between flaviviridae viral RNA depended RNA polymerase and viral helicase? | Several labs have obtained evidence for a protein complex that involves many of the nonstructural (NS) proteins encoded by the virus. NS3, NS4A, NS4B, NS5A, and NS5B appear to interact structurally and functionally. In this study, we investigated the interaction between the helicase, NS3, and the RNA polymerase, NS5B. ... | yes |
converted_3683 | Is there an increased risk for meningiomas in childhood leukemia survivors? | Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). , Combined chemotherapy and prophylactic cranial irradiation has improv... | yes |
converted_3210 | Are cardenolides inhibitors of Na+/K+ ATPase? | . Previously, we reported that a variety of cardenolides impart anti-transmissible gastroenteritis coronavirus (TGEV) activity in swine testicular (ST) cells, through targeting of the cell membrane sodium/potassium pump, Na+/K+-ATPase. , : We found evidence for low cardenolides by HPLC, but substantial toxicity when ex... | yes |
converted_360 | Have thyronamines effects on fat tissue? | In conclusion, trace amines and thyronamines are negative inotropic agents., Their in vivo administration induces effects opposite to those induced by thyroid hormone, including lowering of body temperature.[SEP]Definitions: thyroid hormone defined as following: Natural hormones secreted by the THYROID GLAND, such as T... | no |
converted_2275 | Is Drk essential for anesthesia-resistant memory (ARM) in Drosophila? | Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory inDrosophilaremain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more ... | yes |
converted_2245 | Is there a sequence bias in MNase digestion patterns? | In addition, unlike MNase, MPE-Fe(II) cleaves nuclear DNA with little sequence bias., These findings collectively indicate that MPE-seq provides a unique and straightforward means for the genome-wide analysis of chromatin structure with minimal DNA sequence bias., Micrococcal nuclease does not substantially bias nucleo... | yes |
converted_3360 | Does SATB1 regulate the RAG1 and RAG2 genes? | High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein, Its onset preceded the rearrangement of TCR genes, as Xlr expression was conserved in thymus cells from RAG1(0/0) mice. , An anti-silencer- and SATB1-dependent chromatin h... | yes |
converted_1005 | Is amoxicillin used for treatment of malnutrition in children? | Another RCT did not show superiority of ceftriaxone over amoxicilllin for these same outcomes, but adressed SAM children with and without complications (p = 0.27). Another RCT showed no difference between amoxicillin and cotrimoxazole efficacies for pneumonia in underweight, but not SAM. Our meta-analysis of 12 pooled... | yes |
converted_839 | Are seizures among the neurological symptoms of incontinentia pigmenti? | High-dose glucocorticoid therapy in the management of seizures in neonatal incontinentia pigmenti, Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can ari... | yes |
converted_3243 | Does GRHL2 over-expression lead to EMT? | Grhl2 is down-regulated in disseminated cancer cells that have undergone EMT, and over-expression of Grhl2 is sufficient to induce epithelial gene expression., Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT and tumor progression., In breast cancer cell lines, shRNA-me... | no |
converted_4629 | Is covid-19 induced anosmia caused by disruption of nuclear architecture? | Disruption of nuclear architecture as a cause of COVID-19 induced anosmia., Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components... | yes |
converted_4213 | Is capmatinib effective for glioblastoma? | CONCLUSION: The combination of INC280/buparlisib resulted in no clear activity in patients with recurrent PTEN-deficient glioblastoma. [SEP]Definitions: glioblastoma defined as following: The most malignant astrocytic tumor (WHO grade 4). It is composed of poorly differentiated neoplastic astrocytes and is characterize... | no |
converted_1501 | Have germline variants been associated to colorectal cancer? | Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intron 10 ... | yes |
converted_1651 | Does SCRIB deregulation promote cancer? | human homologs of Drosophila dlg, scrib, and lgl are cancer-associated genes., Aberrant overexpression of the cell polarity module scribble in human cancer., we show that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal t... | yes |
converted_1544 | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | The use of HIPEC after aggressive cytoreductive surgery in patients with ovarian cancer with peritoneal dissemination can be performed with acceptable postoperative morbidity rates. Knowledge of the factors associated with the onset of these postoperative adverse events allows better management of the same and offers t... | yes |
converted_4538 | Is lumbar puncture the first test that should be performed on a patient with increased intracranial pressure? | As an emergency diagnostic procedure, spinal puncture is indicated when CNS infection is suspected or to establish the diagnosis of subarachnoid hemorrhage when results of cranial computed tomography are normal. The major contraindication is elevated intracranial pressure with evidence of a mass lesion., Brain shift is... | no |
converted_1883 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish., he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe... | yes |
converted_1369 | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
converted_3226 | Is myc a tumour suppressor gene? | oncogenic Myc, a master transcription factor that turns on anabolic metabolism to promote cell growth in many cancers. , he MYC oncogene, the proto-oncogene protein c-MYC, however, other genes such as the proto-oncogene c-Myc are promising targets for anticancer therapy[SEP]Definitions: MYC oncogene defined as followi... | no |
converted_4514 | Do angiotensin-converting-enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) increase the likelihood of severe COVID-19? | These findings suggest that the use of ACE-I and ARB is not associated with adverse outcomes and may be associated with improved outcomes in COVID-19, which is immediately relevant to care of the many patients on these medications., There are theoretical concerns that angiotensin-converting enzyme inhibitors (ACEIs) an... | no |
converted_4697 | Is disruption of immune regulation mechanisms associated with adverse pregnancy outcomes, including preeclampsia (PE)? | Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. , Our results indicate these proteins are new factors that play important roles in the ... | yes |
converted_3768 | Is tocilizumab a tumor necrosis factor inhibitor? | For the first-line bDMARD/tsDMARD, either tumor necrosis factor inhibitors (TNFi), non-TNFi (abatacept, tocilizumab, rituximab), or tsDMARDs, may be considered.[SEP]Definitions: rituximab defined as following: A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and ... | no |
converted_2190 | Is there an association between Histone H3.3 mutations and glioma? | PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas. We report a case of thalamic glioma with H3F3A K27M mutation,... | yes |
converted_3162 | Is actin present in the nucleus? | Moreover, inhibition of ATM kinase or deficiency in nuclear actin polymerization causes carcinogenic RET/PTC chromosome rearrangements after DSBs induction in human cells., Our findings establish that nuclear actin-based mobility shapes chromatin organization by generating repair domains that are essential for homolog... | yes |
converted_214 | Are there focused databases from which you can retrieve gene expression data on renal disease? | Proteomics database in chronic kidney disease, Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease[SEP]Definitions: chronic kidney disease defined as following: Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.. renal disease d... | yes |
converted_1962 | Do normal cells express the protein TERT? | Since telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells, it has become a very promising target for anti-cancer therapy, Telomerase plays a pivotal role in cellular immortality and tumorigenesis. Its activity is normally not detectable in most somatic cells while it is rea... | no |
converted_1835 | Do statins cause diabetes? | Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients, The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing ... | yes |
converted_2216 | Is Hepatic mesenchymal hamartoma usually a malignant tumor? | Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, , Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age, This review on the pathology of hepatic tumors in childhood, from a personal series of 245 tumors, focuses on in... | no |
converted_634 | Could Arimidex (anastrozole) cause hot flashes? | More than a third of breast cancer patients undergoing aromatase inhibitor (AI) treatment report joint pain., In the first 6 weeks, emergence of joint pain was associated with increase in general pain, fatigue, disturbed sleep, hot flashes, vaginal dryness, and decreased sexual activity., Antiestrogen therapy can cause... | yes |
converted_1298 | Are there Conserved Noncoding Elements (CNEs) in invertebrate genomes? | Here, we use genome-wide comparisons between C. intestinalis and C. savignyi to identify putative urochordate cis-regulatory sequences. Ciona conserved non-coding elements (ciCNEs) are associated with largely the same key regulatory genes as vertebrate CNEs, We have identified Conserved Non-coding Elements (CNEs) in th... | yes |
converted_2991 | Does Eucommia ulmoides leaf extract ameliorates steatosis/fatty liver induced by high-fat diet? | These results demonstrate that the Du-zhong leaf extract exhibits antihyperlipidemic properties by suppressing hepatic fatty acid and cholesterol biosynthesis with the simultaneous reduction of plasma and hepatic lipids in high fat-fed hamsters., Together, these results suggest that EUE and its active components enhan... | yes |
converted_2549 | Are stress granules membraneous? | PMLOs are different in size, shape, and composition, and almost invariantly contain intrinsically disordered proteins (e.g., eIF4B and TDP43 in stress granules,, Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA me... | no |
converted_3216 | Is collagen matrix of human articular cartilage changing with disease? | The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease., the chondrocytes in ageing articular cartilage have limited capacity to turnover the interterritorial matrix., Type II collagen is a major component of... | no |
converted_3493 | Is there a BRCA mutation analysis in the Greek population? | Comprehensive BRCA mutation analysis in the Greek population. Experience from a single clinical diagnostic center., Germline mutations in the BRCA1 and BRCA2 genes are associated with hereditary predisposition to breast and ovarian cancer. Sensitive and accurate detection of BRCA1 and BRCA2 mutations is crucial for per... | yes |
converted_2324 | Are mutations in the nf1 gene associated with memory? | We hypothesized that NF1 mutations disturb the expression of genes important for memory formation, Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1 mutants. In the present report, our experiments showed that in addition to learning, long-term memory was also ab... | yes |
converted_3337 | Are Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumors(MPNST) rare in neurofibromatosis patients? | Spinal intradural primary malignant peripheral nerve sheath tumors (MPNST) are rare in patients without neurofibromatosis., Primary malignant peripheral nerve sheath tumors (MPNSTs) are extremely rare in patients without a history of neurofibromatosis; only 18 cases have been reported in the English-language literature... | no |
converted_3356 | Is golimumab effective for sarcoidosis? | Introduced monoclonal antibodies (infliximab, etanercept, adaluimumab, golimumab, rituximab), tested for efficacy in other pathologies associated with the formation of granulomas, have a limited application in patients with SA. , Although treatment was well tolerated, neither ustekinumab nor golimumab demonstrated effi... | no |
converted_3033 | Is there a link between BCL11B haploinsufficiency and syndromic neurodevelopmental delay? | BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells., Using massively parallel sequencing we identified 13 patients bearing heterozygous germline alterations in BCL11B. Notably, all of them are affected by global developmental delay with speech impairment and... | no |
converted_3656 | Can Systemic Lupus Erythematosus cause seizures? | The mean ± SD age at SLE diagnosis and at onset of PRES was 25.02 ± 13.78 and 28.31 ± 12.61 years, respectively. Seizure was the most common presenting symptom, as seen in 28 episodes, followed by acute severe headache in 17,, Epilepsy is characterized by a relevant epidemiological and clinical burden. In the extant li... | yes |
converted_4540 | Do only changes in coding regions of MEF2C cause developmental disorders? | Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms., Clinical genetic testing of protein-coding regions identifies a likely causative variant in only around half of developmental disorder (DD) cases. The contribution of regulatory variatio... | no |
converted_3111 | Does Axitinib prolong survival of Pancreatic Cancer patients? | CONCLUSIONS: Axitinib/gemcitabine, while tolerated, did not provide survival benefit over gemcitabine alone in patients with advanced pancreatic cancer from Japan or other regions., RESULTS: Among Japanese patients, median overall survival was not estimable (95% confidence interval, 7.4 months-not estimable) with axiti... | no |
converted_2854 | Is pacritinib effective for treatment of myelofibrosis? | Pacritinib and its use in the treatment of patients with myelofibrosis who have thrombocytopenia., Pacritinib, a dual JAK2 and FLT3 inhibitor which also inhibits IRAK1, has demonstrated the ability to favorably impact MF-associated splenomegaly and symptom burden, while having limited myelosuppression with manageable g... | yes |
converted_4587 | Does atemoya juice inhibit the CYP1A2 enzyme? | Atemoya juice significantly inhibited CYP1A2 activity in human liver microsomes, but not the activities of CYP2C9 and CYP3A., This suggests that the intake of an excess amount of atemoya juice is necessary to cause a change in the pharmacokinetics of phenacetin when the IC50 values for CYP1A2 inhibition by atemoya and ... | yes |
converted_156 | Is the gene MAOA epigenetically modified by methylation? | Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men., We found significant interindividual differences in methylation status and methylation patterns of the core MAOA promoter. , In the present study, DNA methylation patterns in the MAOA regu... | yes |
converted_3263 | Are astrocytes part of the blood brain barrier? | The blood-brain barrier (BBB) is a tight boundary formed between endothelial cells and astrocytes, which separates and protects brain from most pathogens as well as neural toxins in circulation., The blood-brain barrier (BBB) consists of endothelial cells, astrocytes, and pericytes embedded in basal lamina (BL).[SEP]De... | yes |
converted_2436 | Is CREB a key memory protein? | Human cyclic AMP response element binding protein (CREB) transcription factor which plays a crucial role in memory, The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. , A mouse genetic study showed that cAMP-responsive element-binding prot... | yes |
converted_1487 | Does Serca2a bind PLN in the heart? | The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase., Moreover, PLN-R14Del did not co-immunoprecipitate with SERCA2a (as did WT-PLN),, n this review, we attempted to highlight the functional significance of PLN in vertebrate cardiac physiology. We will refer to ... | yes |
converted_3639 | Is poliosis circumscripta another term for a white or unpigmented patch of hair or skin? | "white forelock," poliosis circumscripta, defined as a localized patch of white hair in a group of hair follicle, Although traditionally known as "white forelock," poliosis circumscripta, defined as a localized patch of white hair in a group of hair follicles, can involve any hairy area on the body including the scalp,... | yes |
converted_649 | Is low T3 syndrome related with high BNP in cardiac patients? | BNP and fT3 are independently associated with exercise capacity in severely compromised HF patients., fter adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95%CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95%CI 1.4-6.3) were predictive for mortality afte... | yes |
converted_4679 | Is there any role of the 'Greek islands' in olfactory receptor choice? | Chromatin conformation capture using in situ Hi-C on fluorescence-activated cell-sorted olfactory sensory neurons and their progenitors shows that olfactory receptor gene clusters from 18 chromosomes make specific and robust interchromosomal contacts that increase with differentiation of the cells. These contacts are o... | yes |
converted_3129 | Has Hesperidin any role as a Neuroprotective Agent? | Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease, Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury, Neuroprotective Effects of Hesperidin on Cerebral Vasospasm, The neuro... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.