id stringlengths 11 14 | sentence1 stringlengths 20 168 | sentence2 stringlengths 55 29.8k | label stringclasses 2
values |
|---|---|---|---|
converted_2889 | Does Panitumumab prolong survival of biliary tract cancer patients? | Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: A randomized phase 2 trial (Vecti-BIL study)., CONCLUSIONS: Panitumumab in combination with chemotherapy does not improve ORR, PFS and OS in patients with KRAS wild-type, advanced bilia... | no |
converted_3855 | Does IL18 signaling have a role in thymus? | IL18 signaling promotes homing of mature Tregs into the thymus., Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus., er, we show that IL18R+ T... | yes |
converted_28 | Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3)., Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a., Here, we described the high quality draft genome sequence, annotations and the features ofArthrobactersp. B6., Complete genom... | yes |
converted_1334 | Is protein Fbw7 a SCF type of E3 ubiquitin ligase? | FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase., However, very few E3 ubiquitin ligases are known to target G-CSFR for ubiquitin-proteasome pathway. Here we identified F-box and WD rep... | yes |
converted_4475 | Is Acute Necrotizing Encephalopathy (ANE) which typically affects young, healthy children usually triggered by exposure to air pollution? | Acute necrotizing encephalopathy (ANE) is a recently identified, uncommon encephalopathy affecting children. ANE is characterized by a preceding viral illness followed by seizures and rapid progressive neurologic deterioration. , Acute necrotizing encephalopathy (ANE) is a specific type of encephalopathy usually follow... | no |
converted_3733 | Has saracatinib been tested in clinical trials? | Saracatinib as a metastasis inhibitor in metastatic castration-resistant prostate cancer: A University of Chicago Phase 2 Consortium and DOD/PCF Prostate Cancer Clinical Trials Consortium Study., A phase II study of saracatinib (AZD0530), a Src inhibitor, administered orally daily to patients with advanced thymic malig... | yes |
converted_1241 | Is poly (ADP- ribosylation) involved in transcriptional control? | Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivotal roles in the maintenance of transcriptional fidelity, oly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear protein that is involved in DNA r... | yes |
converted_1122 | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism., Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis, This is the first case of germline mosaicism in tuberous ... | yes |
converted_3829 | Is there any role of genotoxic pks + E. coli in cancer? | Mutational signature in colorectal cancer caused by genotoxic pks+, Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the p... | yes |
converted_4024 | Is the apilimod inhibitor effective against SARS-CoV-2? | To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we profiled a library of known drugs encompassing approximately 12,000 clinical-stage or FDA-approved small molecules. Here, we report the identification of 30 known drugs that inhibit viral replication. Of these, six were characterized for cellu... | yes |
converted_393 | Is there an association between bruxism and reflux? | Sleep bruxism is prevalent in GERD patients, and GERD is highly associated with SB., There was a statistical trend towards tooth wear progression being associated with gastric risk factors (p < 0.05). , This article presents a case report of a 27-year-old male smoker with tooth wear and dentin sensitivity caused by GER... | yes |
converted_4694 | Are there any R packages that help with visualizing data on spirals? | spiralize: an R package for Visualizing Data on Spirals., Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here we present t... | yes |
converted_2410 | Is overproduction of transthyretin is associated with amyloidosis associated neuropathy? | Transthyretin-associated familial amyloid polyneuropathy (TTR-FAP) is a disease caused by the deposit of abnormal transthyretin on tissues, mainly nerves, transthyretin familial amyloid polyneuropathy, We report a new transthyretin (ATTR) gene c.272C>G mutation and variant protein, p.Leu32Val, in a kindred of Bolivian ... | yes |
converted_697 | Are there randomised controlled trials on sevoflurane? | After Ethics Review Board approval, 44 ASA I-III patients undergoing elective gynaecological surgery were randomised after surgery to either hypercapnic hyperpnoea or control groups., Hypercapnic hyperpnoea in spontaneously breathing patients halves the time of recovery from sevoflurane-induced anaesthesia in the opera... | yes |
converted_1000 | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | PTH can induce skeletal synthesis of another potent phosphaturic hormone, fibroblast growth factor 23 (FGF23), , Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that has recently been identified as a CKD-related factor affecting CRS. , circulating phosphaturic hormone fibroblast growth factor-23 levels,... | yes |
converted_4450 | Is SOX10 expressed in melanoma cells? | Our study confirmed that SOX10 is an oncogene and activate Notch signaling pathway, which suggests the potential treatment for melanoma patients by target SOX10/Notch axis., The most commonly used melanocytic markers include S100, Melan-A, HMB45 and SOX10, melanocytic markers melan-A and SOX10 [SEP]Definitions: Melan-A... | yes |
converted_4634 | Is HDAC1 required for GATA-1 transcriptional activity? | HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis., GATA-12RA knock-in (KI) mice suffer mild anemia and thrombocytopenia with accumulation of immature erythrocytes and megakaryocytes in bone marrow and spleen. Single cell RNA-seq analysis of Lin- cKit+ (LK) cells further ... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.