id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 21.3k | label stringclasses 2
values |
|---|---|---|---|
converted_3799 | Can SMAD6 variants cause craniosynostosis? | SMAD6 variants in craniosynostosis: genotype and phenotype evaluation., Enrichment of heterozygous missense and truncating SMAD6 variants was previously reported in nonsyndromic sagittal and metopic synostosis, and interaction of SMAD6 variants with a common polymorphism nearBMP2 (rs1884302) was proposed to contribute ... | yes |
converted_1559 | Are the proteins Erbin (LAP2) and Merlin cooperating? | Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta., The results show that the epithelial-enriched protein Erbin controls the function of the NF2 tumor suppressor Merlin by determining the output of Merlin's physical interactions with active PAK2. , Erbin ... | yes |
converted_124 | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | DITPA normalized the elevated serum T(3) and TSH when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range., The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type TRs with relatively low affinity was unique in that this analog improves left ventricul... | yes |
converted_995 | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification, gfi1aa and gfi1b have distinct roles in regulating primitive and d... | yes |
converted_2552 | Is the consumption of chocolate associated with an increase in cardiovascular disease? | The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke., chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties., A number of studies have shown that dietary polyphen... | no |
converted_2227 | Is Downs syndrome associated with decreased risk of leukemia? | The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population., We present a case of congenital acute myeloid leukemia manifesting from the ver... | no |
converted_2860 | Can CPX-351 be used for the treatment of tuberculosis? | CPX-351 is a novel liposomal formulation of cytarabine and daunorubicin which has recently been FDA approved for treatment of acute myeloid leukemia (AML).[SEP] | no |
converted_4036 | Is colistin an antibiotic? | all antibiotics tested, apart from colistin, , Among the selected antibiotics, there were 12 fluoroquinolone antibiotics (tosufloxacin, levofloxacin, sparfloxacin, clinafloxacin, pazufloxacin, gatifloxacin, enrofloxacin, lomefloxacin, norfloxacin, fleroxacin, flumequine, ciprofloxacin), 15 beta-lactam or cephalosporin ... | yes |
converted_3570 | Is palbociclib effective for glioblastoma? | Although further research is needed, cyclin-dependent kinase 4/6 inhibitors represent intriguing developments in the treatment of various malignancies, including those with such poor prognoses as glioblastoma multiforme, mantle cell lymphoma, and metastatic melanoma., CONCLUSION: In this trial, despite adequate tissue ... | no |
converted_677 | Are there any urine biomarkers for bladder cancer diagnosis? | CONCLUSIONS: Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer, Novel promising markers are in v... | yes |
converted_2788 | Is pembrolizumab effective against Ewing's sarcoma? | None of the 13 patients with Ewing's sarcoma had an objective response. , Between March 13, 2015, and Feb 18, 2016, we enrolled 86 patients, 84 of whom received pembrolizumab (42 in each disease cohort) and 80 of whom were evaluable for response (40 in each disease cohort). [SEP] | no |
converted_742 | Can mutations in Calmodulin cause ventricular fibrillation? | We characterized a family presenting with a history of ventricular fibrillation (VF) and sudden death without ECG or echocardiographic abnormalities at rest. Two siblings died suddenly at the ages of 9 and 10 years, and another two were resuscitated from out-of-hospital cardiac arrest with documented VF at age 10 and 1... | yes |
converted_2284 | Has IVIG been tested in clinical trials for the treatment of Alzheimer's disease? | Clinical trials of intravenous immunoglobulin for Alzheimer's disease., Preclinical and clinical studies have shown that IVIG has anti-amyloid and immune modulatory properties relevant to treating neurodegenerative disorders. In early stage AD clinical trials, IVIG was found to reduce cognitive decline and increase bra... | yes |
converted_2420 | SGOT is an abbreviation for an enzyme other wise known as alanine amino transferase, yes or no? | patients with aspartate amino transferase (SGOT), alanine amino transferase (SGPT),, Alanine amino transferase (SGPT), , aspartate aminotransferase (AST-SGOT), alanine amino-transferase (ALT-SGPT), Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyl... | no |
converted_3855 | Does IL18 signaling have a role in thymus? | IL18 signaling promotes homing of mature Tregs into the thymus., Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus., er, we show that IL18R+ T... | yes |
converted_4400 | Does the royal jelly contain proteins? | We observed differences in the metabolome, proteome, and phytosterol compositions of royal jelly synthesized by nurse bees from multi-pesticide exposed colonies, including significant reductions of key nutrients such as 24-methylenecholesterol, major royal jelly proteins, and 10-hydroxy-2-decenoic acid. , Two-dimensi... | yes |
converted_3620 | Are tumour specific antigens originating from known protein coding genes? | It is well established that MHC class I molecules present peptides from endogenous proteins, such as virus or tumour antigens, to CD8+ T lymphocytes. , So far, human tumour specific antigens that can be presented by HLA molecules have not been identified on the molecular level., These CTLs recognize short peptides deri... | yes |
converted_2451 | Can multiple myeloma patients develop hyperviscosity syndrome? | Multiple myeloma (MM) is an immedicable malignancy of the human plasma cells producing abnormal antibodies (also referred to as paraproteins) leading to kidney problems and hyperviscosity syndrome. , This skin condition may be observed in patients with the following condtions, such as primary polycythemic hyperviscosit... | yes |
converted_3718 | Are there negative enhancers? | Role of a YY-1 factor-binding negative enhancer, Mutations targeted to the CArG-like motif abolished the suppressive effect of the negative enhancer and the inducibility of the promoter during myogenic differentiation, Our results suggest that the activity of the negative enhancer may determine the level of expression ... | yes |
converted_2259 | Does TUC.338 inhibit colorectal cancer? | TUC.338 promotes invasion and metastasis in colorectal cancer., Until now, the role of TUC.338 in colorectal cancers remains undefined. This study revealed that TUC.338 is significantly up-regulated in colorectal cancers (CRC) tissue and CRC cell lines, and the up-regulated TUC.338 is associated with lymph node metasta... | no |
converted_3686 | Does saracatinib promote oncogenesis? | Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer., We evaluated the antitumor effect of a c-Src/Abl kinase inhibitor, saracatinib (AZD0530), alone or combined with chemotherapeutic agents in gastric cancer cell lines and a ... | no |
converted_2973 | Have yeast prions become important models for the study of the basic mechanisms underlying human amyloid diseases? | Endogenous yeast amyloids that control heritable traits and are frequently used as models for human amyloid diseases are termed yeast prions, Fibrous cross-β aggregates (amyloids) and their transmissible forms (prions) cause diseases in mammals (including humans) and control heritable traits in yeast. , These infectiou... | yes |
converted_3543 | Does an interferon (IFN) signature exist for SLE patients? | Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease., In SLE post-transplant, recurrent disease activity and induction of IRF7 protein expression correlated with activation of the IFN signature., JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement... | yes |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_4408 | Does UBE4B promote renal cancer? | UBE4B might act as an oncogene in regulating RCC development. Therefore it could be served as an effective indicator to predict OS and a potential biomarker for targeted therapy of RCC patients.[SEP] | yes |
converted_1950 | Do T-Cells regulate neuropathic pain? | here is evidence for a considerable impact of the immune system also in neuropathic pain. However, the role of the adaptive immune system is still unclear., Our investigation revealed a clear shift of T-cell subsets towards anti-inflammation in patients with neuropathic pain. , GITRL expressed on macrophages drives c... | yes |
converted_2965 | There is no drug available to prevent HIV infection, Pre-exposure prophylaxis (PrEP), yes or no? | pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London - analysis of pharmacokinetics, safety and outcomes., The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also ... | no |
converted_4065 | Is ofatumumab effective for multiple sclerosis? | Anti-CD20 Agents for Multiple Sclerosis: Spotlight on Ocrelizumab and Ofatumumab., Ofatumumab, a fully human anti-CD20 monoclonal antibody, that binds a distinct epitope, has been further investigated in phase 3 trials for relapsing forms of MS. , Conclusion: Ofatumumab offers beneficial outcomes for RMS by reducing re... | yes |
converted_3610 | Is g-H2AX a marker for double strand breaks? | The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). , expression of the DNA double-strand break marker gamma-H2AX (γH2AX) , pH2AX, a marker of the DNA double-strand break (DSB)[SEP] | yes |
converted_381 | Is cadasil syndrome a hereditary disease? | CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast... | yes |
converted_2570 | Is pregabalin effective for sciatica? | CONCLUSIONS: Treatment with pregabalin did not significantly reduce the intensity of leg pain associated with sciatica and did not significantly improve other outcomes, as compared with placebo, over the course of 8 weeks. The incidence of adverse events was significantly higher in the pregabalin group than in the plac... | no |
converted_1167 | Is COL5A2 gene associated to ischemic heart disease? | Analysis of a gene co-expression network establishes robust association between Col5a2 and ischemic heart disease, Col5a2, a gene previously not specifically linked to MI response but responsible for the classic type of Ehlers-Danlos syndrome, was found to have many and strong co-expression associations within this com... | yes |
converted_249 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by xerostomia and altered taste., It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, lips, and hard and soft palate. , BMS is a chronic disorder that frequently ... | yes |
converted_1861 | Is treatment resistant depression related to vitamin B9? | Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in ... | yes |
converted_4055 | Is progeria caused by an autosomal recessive gene? | Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic disease that leads to accelerated aging and often premature death caused by cardiovascular complications. , Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease., Progeria is sp... | yes |
converted_1434 | Does MVIIA and MVIIC bind to the same calcium channel? | We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal cortex infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (omega-conotoxins MVIIA and MVIIC respectively; 6.8 and 45 pmol infused respectively) in rat pups., Additionall... | no |
converted_3007 | Can mitochondria be inherited by both parents in humans? | Biparental Inheritance of Mitochondrial DNA in Humans., Although there has been considerable debate about whether paternal mitochondrial DNA (mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally believed that mitochondria and mtDNA are exclusively maternally inherited in humans. Here, we... | yes |
converted_2938 | Does Groucho related gene 5 (GRG5) have a role only in late development? | Groucho related gene 5 (GRG5) is a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. Here, we describe a previously unknown role of GRG5 in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we ... | no |
converted_3552 | Is the BAGEL algorithm used for arrayed CRISPR screens? | BAGEL: a computational framework for identifying essential genes from pooled library screens., The adaptation of the CRISPR-Cas9 system to pooled library gene knockout screens in mammalian cells represents a major technological leap over RNA interference, the prior state of the art. New methods for analyzing the data a... | no |
converted_694 | Is there a phylogenetic analysis for HIV? | The results of Burst and phylogenetic analysis suggested that the C. neoformans var. grubii strains could be separated into three nonredundant evolutionary groups (Burst group 1 to group 3). , Phylogenetic trees were constructed to evaluate the relationships between the variants, We analyzed pol (protease/reverse trans... | yes |
converted_4609 | Do the proteins Talin and Amot interact? | we show that Amot binds Talin and is essential for relaying forces between fibronectin and the cytoskeleton[SEP] | yes |
converted_516 | Is there an association between TERT promoter mutation and survival of glioma patients? | Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas., Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), Isocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (O... | yes |
converted_3898 | Can saponins be used as adjuvant? | We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants, The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate, BALB/c mice immunized with subcutaneous injections of the recombinant protein... | yes |
converted_375 | Is lambrolizumab effective for treatment of patients with melanoma ? | However, through parallel efforts that have showcased the efficacy of small-molecule BRAF and MAP-ERK kinase (MEK) inhibitors, as well as the immune checkpoint inhibitors, namely ipilimumab and the anti-PD1/PDL1 antibodies (lambrolizumab, nivolumab, MPDL3280), an opportunity exists to transform the treatment of melanom... | yes |
converted_4482 | Is neurofilament light marker for disease? | sNfL levels during the first demyelinating event of MS are associated with greater impairment of BBB integrity, immune cell extravasation, and brain lesion activity on MRI., Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated the correlat... | yes |
converted_156 | Is the gene MAOA epigenetically modified by methylation? | Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men., We found significant interindividual differences in methylation status and methylation patterns of the core MAOA promoter. , In the present study, DNA methylation patterns in the MAOA regu... | yes |
converted_3143 | Velocardial facial syndrome, otherwise known as Di George syndrome is caused by a deletion in chromosome 21, yes or no? | The deletion of chromosome 22q11.2 is involved in the majority of DiGeorge or velo-cardiofacial syndrome., deletions of chromosome 7q11.23 (Williams syndrome), 15q11-q13 (Angelman syndrome, Prader-Willi syndrome) and 22q11 (Di George syndrome), Submicroscopic deletions of chromosome 22q11 have been reported in a multip... | no |
converted_2856 | Can exposure to heavy metals like lead(Pb) or cadmium(Cd) cause changes in DNA methylation patterns in Isoetes sinensis? | DNA methylation in endangered plants after exposure to heavy metals, the Isoetes sinensis, an endangered plant, was stressed with three different concentrations of two heavy metals lead (Pb) and cadmium (Cd), The results showed that the DNA methylated profile of I. sinensis was affected by Pb and Cd stress., The propor... | yes |
converted_3360 | Does SATB1 regulate the RAG1 and RAG2 genes? | High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein, Its onset preceded the rearrangement of TCR genes, as Xlr expression was conserved in thymus cells from RAG1(0/0) mice. , An anti-silencer- and SATB1-dependent chromatin h... | yes |
converted_3344 | Is marimastat effective for small-cell lung cancer? | The phase III trial in small cell lung cancer was discontinued when the results of study 140 were released in February 2001 showing that marimastat was not significantly more effective than placebo in prolonging the survival of small cell lung cancer patients., CONCLUSION: Treatment with marimastat after induction ther... | no |
converted_878 | Is dichlorphenamide effective for periodic paralysis? | BACKGROUND AND PURPOSE: Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP)., In one study dichlorphenamide (DCP) vs placebo was tested in two groups of participants: 42 with hypokalemic periodic paralysis (HypoPP) and ... | yes |
converted_1044 | Does Chromatin Immunoprecipitation (ChIP) show a bias for highly expressed loci? | However, several issues in the processing and analysis of ChIP-chip data have not been resolved fully, including the effect of background (mock control) subtraction and normalization within and across arrays, Proper normalization is essential for ChIP-chip experiments. The proposed normalization technique can correct ... | yes |
converted_2226 | Is there any involvement of L1 retrotransposition in the Rett syndrome? | Using neuronal progenitor cells derived from human induced pluripotent stem cells and human tissues, we revealed that patients with Rett syndrome (RTT), carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposition. Our data demonstrate that L1 retrotransposition can be controlled in a tissue-specif... | yes |
converted_1225 | Is the regulation of Vsr endonuclease independent of the growth phase of bacteria? | Growth phase-dependent regulation of Vsr endonuclease, Vsr endonuclease levels are growth phase dependent., Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli., Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylas... | no |
converted_404 | Is endostatin a proangiogenic factor? | endostatin (antiangiogenic factor, antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin, human endostatin (rh-endostatin), a potential antiangiogenic agent, , antiangiogenic PF4 and endostatin, Angiostatin and endostatin are endogenous inhibitors of angiogenesis with anticancer effects, the ant... | no |
converted_3280 | Is Protoporphyrinogen oxidase localized to the mitochondrium? | We showed that 28 amino acids in the amino terminus of PPOX contain an independently functioning signal for mitochondrial targeting., Based on our results we propose a mechanism for protoporphyrinogen oxidase targeting to the mitochondrion., Mitochondrial targeting of human protoporphyrinogen oxidase., In the present s... | yes |
converted_3449 | Can Flotillin be used as exosomal marker? | Flotillin 1 and tumor susceptibility gene 101 (TSG101), two exosomal marker proteins, , expressed exosomal marker tumor susceptibility gene (TSG) 101 and flotillin (Flot) 1.[SEP] | yes |
converted_3234 | Anaplasma phagocytophilum is an obligate gram-negative, intracellular bacterium, yes or no | The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. ... | yes |
converted_2141 | Is osteocrin expressed exclusively in the bone? | Evolution of Osteocrin as an activity-regulated factor in the primate brain., Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons., Osteocrin (Ostn) is a recentl... | no |
converted_1215 | Is zolpidem an antibiotic? | Zolpidem is a short-acting imidazopyridine hypnotic drug that is metabolized mainly by CYP3A4., FGIN-1-27 and alpidem, like the neurosteroid 3 alpha,21-dehydroxy-5 alpha-pregnane-20-one (THDOC), clonazepam and zolpidem (the direct allosteric modulators of gamma-aminobutyric acidA receptors) delay the onset of isoniazid... | no |
converted_2131 | Is POLD3 essential for mouse development? | The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologs are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizosaccharomyces pombe ortholog is essential. POLD3 also has a specialized role in the repair of broken replication forks, suggesting that POLD3 activity c... | yes |
converted_3434 | Can CMB305 be used against sarcomas? | CMB305 induces NY-ESO-1 specific T cell responses in both SS and MRC patients and these patients had excellent overall survival (OS) outcomes in the initial phase I study., Data suggesting this vaccine may improve OS for SS and MRCL patients is exciting but early, and on-going work is testing the impact of CMB305 on pa... | yes |
converted_68 | Is there any algorithm for enhancer identification from chromatin state? | RFECS: a random-forest based algorithm for enhancer identification from chromatin state., However, only a limited number of cell types or chromatin marks have previously been investigated for this purpose, leaving the question unanswered whether there exists an optimal set of histone modifications for enhancer predicti... | yes |
converted_4629 | Is covid-19 induced anosmia caused by disruption of nuclear architecture? | Disruption of nuclear architecture as a cause of COVID-19 induced anosmia., Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components... | yes |
converted_2055 | Does Jarid2 play a role in early embryo development? | Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development, Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulat... | yes |
converted_4311 | Does bleomycin cause lung toxicity? | bleomycin-induced pulmonary fibrosis, bleomycin (BLM)-induced pulmonary , Pulmonary toxicity is a devastating complication of bleomycin chemotherapy. , Bleomycin containing regimen is routinely employed in the treatment of HL. Pulmonary toxicity due to this drug is the most feared side effect in these regimens where th... | yes |
converted_2619 | Does SARM1 deletion cause neurodegeneration? | Finally, using neurons from two distinct mutant mouse strains whose axons are highly resistant to neurodegeneration (Wld(S) and Sarm1(-/-)), we found that the three different fibrils were secreted by axons after anterograde transport, in the absence of axonal lysis, indicating that trans-neuronal spread can occur in in... | no |
converted_2324 | Are mutations in the nf1 gene associated with memory? | We hypothesized that NF1 mutations disturb the expression of genes important for memory formation, Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1 mutants. In the present report, our experiments showed that in addition to learning, long-term memory was also ab... | yes |
converted_649 | Is low T3 syndrome related with high BNP in cardiac patients? | BNP and fT3 are independently associated with exercise capacity in severely compromised HF patients., fter adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95%CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95%CI 1.4-6.3) were predictive for mortality afte... | yes |
converted_3674 | Thymoquinone is ineffective against radiation induced enteritis, yes or no? | n this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. , In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., TQ... | no |
converted_227 | Can DNA intercalators function as topoisomerase inhibitors? | The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding a... | yes |
converted_3162 | Is actin present in the nucleus? | Moreover, inhibition of ATM kinase or deficiency in nuclear actin polymerization causes carcinogenic RET/PTC chromosome rearrangements after DSBs induction in human cells., Our findings establish that nuclear actin-based mobility shapes chromatin organization by generating repair domains that are essential for homolog... | yes |
converted_1729 | Are mutations in the STXBP1 gene associated with epilepsy? | Folinic acid responsive epilepsy in Ohtahara syndrome caused by STXBP1 mutation., A novel mutation in STXBP1 gene in a child with epileptic encephalopathy and an atypical electroclinical pattern., Mutations in STXBP1 gene, encoding the syntaxin binding protein 1, have been recently described in Ohtahara syndrome, or ea... | yes |
converted_3681 | Is Aptiganel effective for treatment of stroke? | Trends for increased mortality with three NMDA antagonists were seen - selfotel (OR 1.19 [0.81-1.74]), aptiganel (OR 1.32 [0.91-1.93]) and gavestinel (OR 1.12 [0.95-1.32]) - but this did not achieve significance for the NMDA antagonists considered as a class (1.09 [0.96-1.23]). Aptiganel was also associated with a tren... | no |
converted_1059 | Are piRNAs involved in gene silencing? | In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown., Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcri... | yes |
converted_4511 | Is thalidomide used as an immunomodulatory drug nowadays? | Potential immunomodulatory, antiinflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma., In 1990s, however, thalidomide received attention due to the discovery of its anticancer potential derived from antiangiogenic and immu... | yes |
converted_4190 | Do honey contain diastases/amylases? | A new rapid method for the determination of honey diastase activity using direct potentiometric principles has been proposed. , The major alpha-amylase in honey was characterized. , Separation of honey amylase[SEP] | yes |
converted_3584 | Can PRL3-zumab inhibit PRL3+ cancer cells in vitro and in vivo? | Here we show that PRL3-zumab specifically inhibits PRL3+ cancer cells in vivo, but not in vitro.[SEP] | no |
converted_1768 | Is there a role of regorafenib for sarcoma treatment? | Regorafenib has been approved for third-line therapy., Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial., DISCUSSION: The design of this trial allows an assessment of regorafenib activity over placebo in... | yes |
converted_281 | Are reduced-nicotine cigarettes effective for smoking cessation? | CONCLUSIONS: In this 6-week study, reduced-nicotine cigarettes versus standard-nicotine cigarettes reduced nicotine exposure and dependence and the number of cigarettes smoked. , RESULTS: Significant reductions in nicotine intake were observed between usual brand smoking (∼1.2 mg nicotine) and the 0.3 and 0.05 mg nicot... | yes |
converted_4316 | Is fusobacterium associated with Lemierre's syndrome? | Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study., Lemierre's syndrome is defined as an oropharyngeal infection due to Fusobacterium necrophorum,, Lemierre's syndrome is a rare but life-threatening condition characterized by an oropharyng... | yes |
converted_4184 | Are interferons defensive proteins? | In response to viral infections, various pattern recognition receptors (PRRs) are activated for the production of type I interferon (IFN I). , activating interferon (IFN) production and positively regulating antiviral response in mammals. , The innate immune system, in particular the type I interferon (IFN) response, ... | yes |
converted_3173 | Can prevnar 13 be used in children? | PCV13 is approved for routine vaccination of all infants as a 4-dose series at age 2, 4, 6, and 12-15 months for children who previously received 1 or more doses of the 7-valent pneumococcal conjugate vaccine (PCV7), and for children with underlying medical conditions that increase their risk for pneumococcal disease o... | yes |
converted_773 | Is corpus callosum involved in the Mowat–Wilson syndrome? | The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. , Mowat-Wilson syndrome in a fetus with antenat... | yes |
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