id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 21.3k | label stringclasses 2
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converted_1402 | Are there Conserved Noncoding Elements (CNEs) in plant genomes? | Conservation and functional element discovery in 20 angiosperm plant genomes, The detailed view of conservation across angiosperms revealed not only high coding-sequence conservation but also a large set of previously uncharacterized intergenic conservation, Conserved noncoding sequences highlight shared components of ... | yes |
converted_3493 | Is there a BRCA mutation analysis in the Greek population? | Comprehensive BRCA mutation analysis in the Greek population. Experience from a single clinical diagnostic center., Germline mutations in the BRCA1 and BRCA2 genes are associated with hereditary predisposition to breast and ovarian cancer. Sensitive and accurate detection of BRCA1 and BRCA2 mutations is crucial for per... | yes |
converted_2585 | Can CD55 deficiency cause thrombosis? | The loss of CD55 and CD59 renders PNH erythrocytes susceptible to intravascular haemolysis, which can lead to thrombosis and to much of the morbidity and mortality of PNH. , CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis., CONCLUSIONS: CD55 deficiency with hyperactivation of complement, angiop... | yes |
converted_2522 | Does Uc.160 promote cancer? | We previously discovered the downregulation of T-UCR expression in gastric cancer (GC), indicating that T-UCRs could play an important role in GC biology. Uc.160+, a T-UCR reported to be downregulated in human cancer, has not been examined in GC.METHODS: We analyzed the expression pattern of Uc.160+ in nonneoplastic an... | no |
converted_1122 | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism., Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis, This is the first case of germline mosaicism in tuberous ... | yes |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_4444 | Can epigenetic modifications be heritable? | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. [SEP] | yes |
converted_218 | Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of vitamin D3 for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). , The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing fall... | yes |
converted_4366 | Is there a genetic cause of craniostenosis? | Apert syndrome - acrocephalosyndactyly - is a rare autosomal dominant disorder representing 1:65 000 cases of living newborns. Characteristic malformations of the Apert syndrome are early craniostenosis, microviscerocranium and II-V finger syndactyly of hand and toes with proximal phalanx of the bilateral thumb "in del... | yes |
converted_2843 | Is ADP-ribosylation a PTM? | ADP-ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine dinucleotide (NAD+) to modify target proteins with ADP-ribose, Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is critically involved in many biological processes that are linked to cell stress... | yes |
converted_2040 | Does Yersinia pestis causes a respiratory infection? | Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia, Yersinia pestis causes the fatal respiratory disease pneumonic plague., Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal disease., Pulmon... | yes |
converted_1985 | Does HuR bind to the untranslated regions (UTRs) of mRNAs? | HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3'UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes., Human antigen R (HuR) is a ubiquitous 32 kDa protein comprising three RNA Recognition ... | yes |
converted_733 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
converted_2587 | Are sleep apnea and snoring associated with cardiac arrhythmias? | Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF., There is a growing consensus in the scientific community that suggests a s... | yes |
converted_3373 | Is the drug Exubera currently (March 2020) available? | Despite discontinuation of the first inhalable insulin, Exubera®, due to suboptimal market acceptance, development of orally inhaled insulin delivery systems has been galvanized by the recent approval of Afrezza® and several others awaiting approval.[SEP] | no |
converted_1775 | Is exon skipping correlated with exon circularization? | Exon Skipping Is Correlated with Exon Circularization, We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome, Exon Skipping Is Correlated with Exon Circularization., We find that circularization of ... | yes |
converted_2370 | Can the yeast protein Abf1 act as insulator? | Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a potent insulating capacity, Insulating domains in Rap1p coincide with previously described transcription activation domains, whereas four adjacent subdomains spanning the whole of the Abf1p C terminus (440-731) were found to display autonomous insulat... | yes |
converted_1989 | Does CRISPR inversion of CTCF sites alter genome topology? | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function, To test the functional significance of this observation, we combined CRISPR/Cas9-based genomic-DNA-fragment editing with chromosome-conformation-capture experiments to show that the location and relative orientations of CBSs determine... | yes |
converted_980 | Is there a relationship between junctin and ryanodine receptors? | Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. , Junctin ablation appears to affect how RyRs 'sense' SR Ca(2+) load, resulting in decreased diastolic SR Ca(2+) leak despite an elevated [C... | yes |
converted_2372 | Is there any linear-time and linear-space algorithm for the computation of avoided words in biological sequences? | The systematic search for avoided words is particularly useful for biological sequence analysis. We present a linear-time and linear-space algorithm for the computation of avoided words of lengthkin a given sequencex. We suggest a modification to this algorithm so that it computes all avoided words ofx, irrespective of... | yes |
converted_528 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. , The vein graft s... | yes |
converted_3364 | Is PRDM9 essential for meiosis? | Our findings do not identify the nature of the underlying DNA sequences, but argue against the proposed role of Prdm9 as an essential transcription factor in mouse meiosis, PRDM9 gene polymorphism may not be associated with defective spermatogenesis in the Chinese Han population, PRDM9 is essential for the progression ... | yes |
converted_1562 | Is abdominal pain a common symptom in autism? | Participants included 132 children with ASD and 81 with special educational needs (SEN) but no ASD, aged 10-14 years plus 82 typically developing (TD) children, The ASD group had significantly increased past vomiting and diarrhoea compared with the TD group and more abdominal pain than the SEN group, Many children with... | yes |
converted_2662 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer., We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype.[SEP] | no |
converted_4419 | Is Sotatercept effective for Pulmonary Arterial Hypertension? | Sotatercept for the Treatment of Pulmonary Arterial Hypertension., CONCLUSIONS: Treatment with sotatercept resulted in a reduction in pulmonary vascular resistance in patients receiving background therapy for pulmonary arterial hypertension., Sotatercept for the Treatment of Pulmonary Arterial Hypertension, CONCLUSIONS... | yes |
converted_3539 | Are gut microbiota profiles altered by irradiation? | Specific Members of the Gut Microbiota are Reliable Biomarkers of Irradiation Intensity and Lethality in Large Animal Models of Human Health., Irradiation profoundly impacted gut microbiota profiles in both animals., Our findings suggest that gut symbiont-based probiotics can be used as agents for reversing radiation-i... | yes |
converted_418 | Is there evidence that tomato juice lowers cholesterol levels? | The hypocholesterolemic effect of tomato juice has been investigated in an intervention study with rats, along with the possible inhibition effect of bioactive tomato compounds binding to the HMGCR enzyme., The molecular modelling showed that components of tomato can bind to the active site of the enzyme and compete wi... | yes |
converted_2111 | Does the TOP2B/TOP2A expression ratio affect the response to AML chemotherapy? | High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia, Genes with distinct expression profiles such as TOP2B/TOP2A expression ratio at diagnosis can be employed for outcome prediction after the treatment with standard regimens in AML patie... | yes |
converted_3655 | Does gavestinel improve outcomes of stroke patients? | CONCLUSION: Consistent with the clinical outcomes in the GAIN trials, no effects of gavestinel on ischemic infarction was observed., No effects of gavestinel on infarct volume were observed in the primary or other analyses. , Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the... | no |
converted_4261 | Is Lysozyme abundant in human tears? | lysozyme present in the natural tear, Lysozyme (Lyz) is a naturally occurring enzyme that operates against Gram-positive bacteria and leads to cell death. This antimicrobial enzyme forms the part of the innate defense system of nearly all animals and exists in their somatic discharges such as milk, tears, saliva and ur... | yes |
converted_3006 | Is galcanezumab effective for treatment of migraine? | Importance: Galcanezumab (LY2951742), a monoclonal antibody against calcitonin gene-related peptide (CGRP), is one of a novel class of new medicines for migraine prevention., Conclusions and Relevance: Monthly subcutaneous injections of galcanezumab, both 120 mg and 300 mg, demonstrated efficacy (repeated-measures anal... | yes |
converted_3371 | Does clinical trial data support the use of minocycline for amyotrophic lateral sclerosis? | Two double-blind, randomized, placebo-controlled feasibility trials of minocycline in ALS were conducted. , This pilot study shows that minocycline and riluzole can be taken safely together. Further trials are needed to assess efficacy of such treatment., It reduces apoptosis in mouse models of Huntington's disease and... | no |
converted_3936 | Is cabergoline used for treatment of the Nelson's syndrome ? | Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time. , Identification of D(2) receptors in corticotroph tumors led to clinical trials of cabergoline therapy in limited cases of Nelson's syndrome, ectopic ACTH-sec... | yes |
converted_3682 | Is indinavir effective for treatment of amyotrophic lateral sclerosis? | Group differences in the rate of decline were not significant between the groups for the ALS Functional Rating Scale (p = 0.36) or for the secondary variables. The toxicity and negative efficacy trends discourage further indinavir trials in ALS.[SEP] | no |
converted_1865 | Is adalimumab effective for hidradenitis suppurativa? | If patient is not improved, then Adalimumab 160 mg at week 0, 80 mg at week 2; then 40 mg subcutaneously weekly should be administered (LOE Ib, SOR A). If improvement occurs then therapy should be maintained as long as HS lesions are present., Reduction in pain scores and improvement in depressive symptoms in patients ... | yes |
converted_2667 | Is transcription of eRNA bidirectional? | In addition to widespread transcription of long non-coding RNAs (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referred to as enhancer RNAs (eRNAs)., Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene a... | yes |
converted_1853 | Could hypophosphatemic rickets cause craniosynostosis? | This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. , Hypophosphatemic rickets and craniosynostosis: a multicenter case series., A 20-year retrospective review identified patients with hypophosphatemic ric... | yes |
converted_51 | Is peripheral neuroepithelioma related to Ewing sarcoma? | The term "small round-cell tumor" describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with high nuclear to cytoplasmic ratios. This group includes Ewing's sarcoma (ES), peripheral neuroepithelioma (aka, primitive neuroectodermal tumor or extraskelet... | yes |
converted_5 | Does metformin interfere thyroxine absorption? | LT4 absorption is unchanged by concomitant metformin ingestion., It has been hypothesized that metformin may suppress serum thyrotropin (TSH) concentrations by enhancing LT4 absorption or by directly affecting the hypothalamic-pituitary axis.[SEP] | no |
converted_274 | Is single-cell analysis (SCA) possible in proteomics? | Toward Single Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry., he advent of proteomics and genomics at a single-cell level has set the basis for an outstanding improvement in analytical technology and data acquisition., The new-generation technology of single-cell analysi... | no |
converted_2179 | Is airplane stroke syndrome a common disease. | Only 37 cases of stroke during or soon after long-haul flights have been published to our knowledge. , Our centre admitted 5727 stroke patients, of whom 42 (0.73%) had flight-related strokes., The authors report three cases of ischemic stroke in young adults that occurred during or after an airplane flight.[SEP] | no |
converted_1272 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals, The phytochemical, curcumin, has been reported to play many beneficial roles., Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive p... | yes |
converted_1804 | Is RASA2 involved in melanoma? | Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated wit... | yes |
converted_3284 | Do de novo truncating mutations in WASF1 cause cancer? | De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures., Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autis... | no |
converted_2668 | Is the protein pelota a ribosomal rescue factor? | a novel binding partner of the ribosome recycling protein Pelota, n eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. , In eukaryotes, the protein complex of Pelota (yeast Dom34) and Hbs1 translational GTPase recognizes the stalled ribosome cont... | yes |
converted_1530 | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels., The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes., at hyperthyroid p... | no |
converted_1447 | Has silicon been used in treatment of incontinence ? | an artificial anal sphincter. Worldwide, there are two established devices on the market: the artificial bowel sphincter® (ABS) from A. M. S. (Minnetonka, MN, USA) and the soft anal band® from A. M. I. (Feldkirch, Austria). How to implant the artificial anal sphincter? Both devices consist of a silicon cuff which can b... | yes |
converted_213 | Is protein M3/6 a dual specificity phosphatase? | Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus., The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi. , This study examines the molecular mechanism... | yes |
converted_2223 | Are selenium supplements recommended for prostate cancer prevention? | Our meta-analysis in prospective studies demonstrated a significant inverse association between selenium status and CVD risk within a narrow selenium range and a null effect of selenium supplementation on CVD was observed in RCTs. These findings indicate the importance of considering selenium status, dose and safety in... | no |
converted_1377 | Is there a relation between ANP and transcapillary albumin escape? | Thus, in a large ethnically homogeneous cohort of diabetic subjects, our data show: (1) a significant association of C708/T polymorphism with microalbuminuria in long-term diabetes and with both lower plasma ANP levels and widespread albumin leakage, hese results suggest a possible role of PND gene in conferring protec... | yes |
converted_4540 | Do only changes in coding regions of MEF2C cause developmental disorders? | Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms., Clinical genetic testing of protein-coding regions identifies a likely causative variant in only around half of developmental disorder (DD) cases. The contribution of regulatory variatio... | no |
converted_3070 | Are recessive coding variants responsible for the majority of undiagnosed nonconsanguineous individuals? | Our results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.[SEP] | no |
converted_2577 | Is Citrobacter rodentium pathogenic? | One day after colonization, mice were infected with the colonic pathogen, Citrobacter rodentium., The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases., EPEC-like... | yes |
converted_1302 | Does thyroid hormone signaling affect microRNAs expression in the heart? | e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a., On the other hand, T₃ treatment increased miR-35... | yes |
converted_1152 | Does thyroid hormone affect cardiac remodeling ? | Thyroid hormones exert important effects on heart remodeling through mir-208., RV and RA function and mechanics are significantly affected by SHT. l-T4 therapy and 1-year maintenance of euthyroid status improved but did not completely recover RV and RA function and deformation in the SHT patients, which implies that ri... | yes |
converted_3321 | Is there a vaccine for rotavirus? | Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5), This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5), Effectiveness of rotavirus pentavalent vaccine, rotavirus pentavalent vaccine (RotaTeq®) as a sole vaccine, We describe rotavirus vaccine coverage and missed oppor... | yes |
converted_969 | Are Sidekick proteins members of the immunoglobulin superfamily? | Here we show that four closely related immunoglobulin superfamily (IgSF) adhesion molecules--Dscam (Down's syndrome cell adhesion molecule), DscamL (refs 6-9), Sidekick-1 and Sidekick-2, Sidekick-1, a cell adhesion molecule of the immunoglobulin superfamily, is up-regulated in glomerular podocytes in the collapsing glo... | yes |
converted_1105 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | Mutations in human TRα1 mediate RTH with features of hypothyroidism in particular tissues (e.g. skeleton, gastrointestinal tract), but are not associated with a markedly dysregulated pituitary-thyroid axis., Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor[SEP] | yes |
converted_690 | Are retroviruses used for gene therapy? | Several immunodeficiencies have been treated successfully by stem cell-targeted, retroviral-mediated gene transfer with reconstitution of the immune system following infusion of the transduced cells., In this work we have developed and tested a self-inactivating (SIN) gammaretroviral vector (SINfes.gp91s) containing a ... | yes |
converted_983 | Have mutations in the ZEB2 gene been found in any human syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene, Mowat-Wilson syndrome (MWS; OMIM#235730) have characteristic facial features, a variety of congenital anomalies such as Hirschsprung disease, and intellectual disabilities ca... | yes |
converted_2795 | Is chlorotoxin a peptide? | chlorotoxin peptide , Chlorotoxin (CTX) is a 36-amino-acid disulfide-containing peptide derived from the venom of the scorpion Leiurus quinquestriatus., The mature Odontobuthus doriae chlorotoxin peptide has a 35-amino-acid residue and four disulfide bounds. , Chlorotoxin (CTX), a disulfide-rich peptide from the scorpi... | yes |
converted_3938 | Is carpal tunnel syndrome a type of nerve entrapment? | Carpal tunnel syndrome (CTS) is a common entrapment neuropathy, often requiring carpal tunnel release (CTR) surgery., Carpal tunnel syndrome (CTS) is an entrapment neuropathy accounting for up to 90% of nerve compression syndromes, Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy in humans. , C... | yes |
converted_4236 | Is SMOC2 expressed during wound healing? | All three fibroblast populations were PDGFRα+/CD34 + but were distinct in their expression of Ngfr/Spon2/Angptl7 (F1), Cxcl14/Smoc2/Rgs2 (F2), and Clec3b/Col14a1/Mmp3 (F3), with potential functions in the regulation of immune responses, response to wounding, and organization of extracellular matrix, respectively., Defi... | yes |
converted_4647 | Is telomestatin, a novel statin drug used to treat high cholesterol? | Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very potent telomerase inhibitor., Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex., Activity of a novel G-quadruplex-interactive t... | no |
converted_128 | Is MammaPrint cleared by the United States Food and Drug Administration? | Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel.[SEP] | yes |
converted_88 | Is fatigue prevalent in patients receiving treatment for glioblastoma? | By contrast, fatigue worsened over time, with a difference in mean score of 5.6 points between baseline and 4-month follow-up (P=.02)., In the GB cohort, the most common side effects were fatigue (56 %), diarrhea (44 %), neutropenia (31 %), and thrombocytopenia (25 %). , A total of 37 patients were treated, and treatme... | yes |
converted_259 | Is oxidative stress affected by FOXO expression? | Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress., Statin-mediated upregulation of klotho expression and differential regulation of FoxO expression promote resistance to CsA-induced oxidative stres... | yes |
converted_432 | Is it possible to detect survivin protein expression in normal human adult tissues? | Survivin (BIRC5) is one of the members of IAP-family apoptosis inhibitors. The BIRCS gene is expressed in most human embryonic tissues and malignant tumors but not in normal differentiated tissues of adult human., Survivin is an inhibitor of apoptosis that is undetectable in most terminally differentiated normal human ... | no |
converted_3930 | Has the olive tree pollen proteome been studied? | Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome. [SEP] | yes |
converted_4183 | Is Tranexamic acid effective for intracerebral haemorrhage? | Tranexamic acid did not increase the risk of post-intracerebral haemorrhage seizures in the first 90 days., The primary outcome was not different between the two groups: 26 (52%) patients in the placebo group and 22 (44%) in the tranexamic acid group had intracerebral haemorrhage growth (odds ratio [OR] 0·72 [95% CI 0·... | no |
converted_3965 | Is co-loss of BRCA2-RB1 associated with better prognosis for prostate cancer patients? | In human prostate cancer cell lines (LNCaP and LAPC4), loss of BRCA2 leads to the castration-resistant phenotype. Co-loss of BRCA2-RB1 in human prostate cancer cells induces an epithelial-to-mesenchymal transition, which is associated with invasiveness and a more aggressive disease phenotype. Importantly, PARP inhibito... | no |
converted_891 | Is NOD1 activated in inflammation? | Nod1 and Nod2 control bacterial infections and inflammation, The Nod proteins Nod1 and Nod2 are two NLR family members that trigger immune defense in response to bacterial peptidoglycan, Nod proteins fight off bacterial infections by stimulating proinflammatory signaling and cytokine networks and by inducing antimicrob... | yes |
converted_4546 | Is METTL1 overexpression associated with better patient survival? | Here we find METTL1 is frequently amplified and overexpressed in cancers and is associated with poor patient survival. METTL1 depletion causes decreased abundance of m7G-modified tRNAs and altered cell cycle and inhibits oncogenicity. Conversely, METTL1 overexpression induces oncogenic cell transformation and cancer. ... | no |
converted_4070 | Is there a role for Dickkopf-1 (DKK1) in prostate cancer? | Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer., Metastatic castration-resistant prostate cancer (mCRPC) with low androgen receptor (AR) and without neuroendocrine signaling, termed double-negative prostate cancer (DNPC), is increasingly prevalent in patients treated with AR si... | yes |
converted_3269 | Is Li–Fraumeni syndrome a rare, autosomal recessive, hereditary disorder that predisposes carriers to cancer development? | Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome inherited in an autosomal dominant fashion that involves a germline mutation of tumor protein 53 (TP53). , Li-Fraumeni syndrome (LFS), a multiorgan cancer predisposition caused by germline TP53 mutations, confers significant cancer risks for young peop... | no |
converted_2280 | Is enzastaurin effective treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_2105 | Does the word ovine refers to goats? | Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep that has rarely been found in goats. , In sheep, a bronchiolo-alveolar carcinoma, known as ovine pulmonary carcinoma (OPC), is caused by jaagsiekte sheep retrovirus (JSRV), an exogenou... | no |
converted_900 | Are there plasma membrane receptors for thyroid hormones? | ntegrins are heterodimeric structural components of the plasma membrane whose ligands include a large number of extracellular matrix (ECM) proteins. , Recently, integrin αvβ3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrote... | yes |
converted_1497 | Is depression associated with poor prognosis of brain tumor patients? | Before surgery 27 patients (35%) had BDI scores indicating the presence of depression. These scores were significantly higher in patients with a history of depression (p = 0.017) and in those with a lower functional outcome (p = 0.015)., A lower functional status (KPS score < or = 70) in patients was significantly asso... | yes |
converted_2391 | Does the association of PARP1 and CTCF follow a circadian rhythm? | here we uncovered an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated domains (LADs)., Synchronization of the circadian rhythm by serum shock induces oscillations in PARP1-CTCF interactions, which is accompanied by oscillating recruitment of circadian loci to t... | yes |
converted_3810 | Can AGY be used as antidiuretic replacement therapy? | AGY, a Novel Egg Yolk-Derived Anti-gliadin Antibody, Is Safe for Patients with Celiac Disease., Oral egg yolk anti-gliadin antibody (AGY) is a novel treatment to neutralize gluten and may improve the efficacy of the GFD., To determine the safety, tolerability, and potential efficacy of AGY in patients with CD., Most pa... | no |
converted_1948 | Do IEG create a ripple effect of transcription? | Rapid induction of immediate-early genes (IEGs) in response to growth factor stimulations is accompanied by co-upregulation of their neighbouring genes., Even in surrounding intergenic regions, transcriptional activation took place at the same time. , Here we show that intensive transcription at one locus frequently sp... | yes |
converted_835 | Is metabolic syndrome related with cardiovascular disease? | The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). , As a molecular link between metabolic signals, i... | yes |
converted_2780 | Is cariprazine effective for treatment of bipolar disorder? | BACKGROUND: We evaluated the safety/tolerability of longer-term open-label treatment with cariprazine in patients who had responded to cariprazine for acute bipolar mania., Clinically relevant response and remission outcomes in cariprazine-treated patients with bipolar I disorder., Cariprazine is FDA approved for the a... | yes |
converted_3157 | Is Apelin usually decreased in diabetes? | Apelin has been shown to act on glucose and lipid metabolism but also to modulate insulin secretion. Moreover, different studies in both animals and humans have shown that plasma apelin concentrations are usually increased during obesity and type 2 diabetes., Upregulated expression of resistin, vaspin, apelin and TNF-α... | no |
converted_4428 | Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila? | Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning., Here, using the dorsoventral patterning of the Drosophila melanogaster embryo as a model system, we provide evidence for the independence of chromatin organization and dorsoventral gene expression. We define tissue-sp... | no |
converted_1134 | Are Drosophila ultraconserved elements candidate ncRNAs? | Highly constrained intergenic Drosophila ultraconserved elements are candidate ncRNAs., Here, we report the discovery and characterization of UCEs from 12 sequenced Drosophila species. We identified 98 elements ≥80 bp long with very high conservation across the Drosophila phylogeny. Population genetic analyses reveal t... | yes |
converted_3832 | Is the Paramyxovirus geneome segmented, negative-sense RNA? | The paramyxovirus family has a genome consisting of a single strand of negative sense RNA, The avian paramyxovirus type 1 (APMV-1), or Newcastle disease virus (NDV), comprise a diverse group of viruses with a single-stranded, negative-sense RNA genome., Members of the Paramyxoviridae such as measles, mumps, and parainf... | no |
converted_1644 | Is Calcium/Calmodulin dependent protein kinase II (CaMKII) involved in cardiac arrhythmias and heart failure? | In human hypertrophy, both CaMKII and PKA functionally regulate RyR2 and may induce SR Ca(2+) leak. In the transition from hypertrophy to HF, the diastolic Ca(2+) leak increases and disturbed Ca(2+) cycling occurs. This is associated with an increase in CaMKII- but not PKA-dependent RyR2 phosphorylation. CaMKII inhibit... | yes |
converted_3662 | Should Lubeluzole be used for treatment of ischemic stroke? | Lubeluzole showed promising neuroprotective effects in animal stroke models, but failed to show benefits in acute ischemic stroke in humans. , However, clinical research on lubeluzole is now at a standstill, since lubeluzole seems to be associated with the acquired long QT syndrome and ventricular arrhythmias. , Ten cl... | no |
converted_3323 | Is BNN20 involved in Parkinson's disease? | Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). However, in most cases, they cannot readily cross the human blood-brain-barrier (BBB). Herein, we propose as a therapeutic for PD the small molecule 17-beta-spiro-[5-androsten-17,2'-ox... | yes |
converted_1896 | Has whole exome sequencing been performed in Alzheimer patients? | Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants., We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) families followed by functional studies of select variants., Whole-exome... | yes |
converted_855 | Do carmustine wafers improve survival of glioblastoma patients? | At recurrence, treatment options include repeat surgery (with or without Gliadel wafer placement), reirradiation or systemic therapy. , DISCUSSION: Carmustine wafers for primary HGG surgery in accordance with the NICE TA121 were associated with a median survival of 15.3 months; this is improved compared with previously... | yes |
converted_1467 | Are BRAF mutations common in melanoma? | patients with BRAF-mutant melanoma., BRAF-mutated melanoma , The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in part... | yes |
converted_28 | Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3)., Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a., Here, we described the high quality draft genome sequence, annotations and the features ofArthrobactersp. B6., Complete genom... | yes |
converted_1619 | Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor., The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancreatic islet... | yes |
converted_67 | Is TENS machine effective in pain? | Transcutaneous electrical nerve stimulation is widely used in pain management but its effectiveness depends on the stimulation being targeted appropriately, hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain., The results of this study have provided evidence of... | yes |
converted_1055 | Does splicing occur co-transcriptionally? | Researchers working in multiple model organisms - notably yeast, insects and mammalian cells - have shown that pre-mRNA can be spliced during the process of transcription (i.e. co-transcriptionally), as well as after transcription termination (i.e. post-transcriptionally), The consensus view, based on four organisms, i... | yes |
converted_4120 | Are Gram positive bacteria able to release extracellular vesicles? | Gram-negative and Gram-positive bacteria release a variety of membrane vesicles through different formation routes. , Release of extracellular vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria. However, the biogenesis and downstream biological effects of EVs released from gram-positive bacteria... | yes |
converted_3060 | Does the interaction of MOV10 and RNASEH2 promote L1 retrotransposition? | Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition., We show that MOV10 interacts with RNASEH2, and their interplay is crucial for restricting L1 retrotransposition. , Furthermore, we show that RNASEH2-MOV10-mediated L1 restriction downregulates expression of the rheumatoid arthritis-associated infl... | no |
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