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converted_84 | Is valproic acid effective for glioblastoma treatment? | A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma., PURPOSE: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in precl... | yes |
converted_646 | Are chromomethylases present in animal genomes? | Many plant, animal, and fungal genomes contain cytosine DNA methylation in asymmetric sequence contexts (CpHpH, H = A, T, C)., However, at the SUPERMAN locus, asymmetric methylation was only completely abolished in drm1 drm2 chromomethylase 3 (cmt3) triple mutant plants., Although neither the drm1 drm2 double mutants n... | no |
converted_2657 | Are AAV vectors considered for the treatment of retinal dystrophies? | These novel gene vectors aim to more safely and efficiently transduce retinal cells, expand the gene packaging capacity of AAV, and utilize new strategies to correct the varying mechanisms of dysfunction found with inherited retinal dystrophies. [SEP]Relations: retinal dystrophy in systemic or cerebroretinal lipidoses... | yes |
converted_1974 | Does mTOR regulate the translation of MAPKAPK2? | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype., Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show p... | yes |
converted_3792 | Is tocilizumab a csDMARD? | The task force agreed on 5 overarching principles and 12 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GCs); biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, inflixim... | no |
converted_2782 | Can breastfeeding confer protection from type I diabetes? | In the neonate and infant, among other benefits, lactation confers protection from future both type 1 and type 2 diabetes.[SEP] | yes |
converted_4031 | Was golimumab tested for diabetes? | CONCLUSIONS: Among children and young adults with newly diagnosed overt type 1 diabetes, golimumab resulted in better endogenous insulin production and less exogenous insulin use than placebo. , Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes., lticenter, placebo-controlled, double-blind, paral... | yes |
converted_4538 | Is lumbar puncture the first test that should be performed on a patient with increased intracranial pressure? | As an emergency diagnostic procedure, spinal puncture is indicated when CNS infection is suspected or to establish the diagnosis of subarachnoid hemorrhage when results of cranial computed tomography are normal. The major contraindication is elevated intracranial pressure with evidence of a mass lesion., Brain shift is... | no |
converted_4357 | Is MEDI2228 a bispecific antibody? | We here delineated the molecular and cellular mechanisms underlying novel immunomodulatory effects triggered by BCMA pyrrolobenzodiazepine (PBD) antibody drug conjugate (ADC) MEDI2228 which can augment efficacy of these immunotherapies.[SEP]Relations: molecular system has relations: anatomy_anatomy with gABAergic syste... | no |
converted_2424 | Are organisms in the genus Morexella associated with sepsis? | Out of 130 culture proven cases of neonatal sepsis, gram negative bacteria were found in 71 (54.6%) cases and gram positive bacteria in 59 (45.4%) cases. Staphylococcus aureus was the most common bacteria found in 35 (26.9%) cases followed by Escherichia coli in 30 (23.1%) cases. Acinetobacter species, Staphylococcus e... | yes |
converted_159 | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | Charcot-Marie-Tooth disease type 2D (CMT2D) is an autosomal-dominant axonal peripheral neuropathy characterized by impaired motor and sensory function in the distal extremities. Mutations in the glycyl-tRNA synthetase (GARS) gene cause CMT2D, Dominant mutations in GARS cause rare forms of Charcot-Marie-Tooth disease an... | yes |
converted_1865 | Is adalimumab effective for hidradenitis suppurativa? | If patient is not improved, then Adalimumab 160 mg at week 0, 80 mg at week 2; then 40 mg subcutaneously weekly should be administered (LOE Ib, SOR A). If improvement occurs then therapy should be maintained as long as HS lesions are present., Reduction in pain scores and improvement in depressive symptoms in patients ... | yes |
converted_506 | Are there conserved noncoding elements identified between genomes of human and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogenetically and functio... | yes |
converted_773 | Is corpus callosum involved in the Mowat–Wilson syndrome? | The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. , Mowat-Wilson syndrome in a fetus with antenat... | yes |
converted_1544 | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | The use of HIPEC after aggressive cytoreductive surgery in patients with ovarian cancer with peritoneal dissemination can be performed with acceptable postoperative morbidity rates. Knowledge of the factors associated with the onset of these postoperative adverse events allows better management of the same and offers t... | yes |
converted_3649 | Is SATB1 expressed in thymocytes? | A thymocyte factor SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter genes., SATB1 is a homeodomain protein and is predominantly expressed in thymocytes. , SATB1 is a cell-type specific nuclear protein that recruits chromatin-remodeling factors and regulates numerous genes dur... | yes |
converted_2874 | Are phagosomal proteins ubiquitinated? | Phagosomal proteins are ubiquitylated, and ubiquitylation was found to be required for formation of acidic multivesicular structures., membranes of the bacterial phagosome are enriched with ubiquitinated proteins in a way that requires its Dot/Icm type IV secretion system, suggesting the involvement of effectors in the... | yes |
converted_286 | Is pregabalin effective for treatment of patients with restless leg syndrome? | CONCLUSIONS: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. , CONCLUSIONS: Pregabalin provided signi... | yes |
converted_93 | Have Quantitative Trait Loci affecting splicing (splicing QTLs) been linked to disease? | The spontaneously hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. Previously we identified thousands of cis-regulated expression quantitative trait loci (eQTLs) across multiple tissues using a panel of rat recombinant inbred (RI) strains derived from Brown Norway and SHR pro... | yes |
converted_999 | Has single guide RNA been used on human cells? | We used a library containing 73,000 sgRNAs to generate knockout collections and performed screens in two human cell lines., Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering transcriptional activation domains either directly to a nuclease-null Cas9 protein or to an aptamer-... | yes |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_2210 | Is dupilumab an antibody targeting the IL-1 receptor? | Atopic dermatitis (AD) is characterized by type 2 helper T (Th2) cell-driven inflammation. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2-mediated pathways., Dupilumab, a humanized monoclonal antibody to ... | no |
converted_2903 | Should dacomitinib be used for treatment of glioblastoma patients? | Expert opinion: Despite the poor global results of Dacomitinib in recurrent GB shown in a phase II trial, some patients had a significant benefit. , Conclusions: Dacomitinib has a limited single-agent activity in recurrent GB with EGFR amplification., Expert opinion: Despite the poor global results of Dacomitinib in re... | no |
converted_191 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | This study reports the consequences of LT4 treatment over a prolonged period of time in 2 of the first patients with a heterozygous mutation in TRα1., Here we show that the dysregulation of the pituitary-thyroid axis was worsened by the lack of TR alpha1 in TR betaPV mice, and severe impairment of postnatal growth was ... | yes |
converted_187 | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO t... | yes |
converted_146 | Is SLC22A3 expressed in the brain? | The organic cation transporter (OCT) 3 is widely expressed in various organs in humans, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that OCT3 expressed in the brain plays an important role in the regulation of neurotransmission. , The organic cati... | yes |
converted_1502 | Can Alzheimer's disease related miRNAs be detected in patients' blood? | miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD., miRN... | yes |
converted_528 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. , The vein graft s... | yes |
converted_4629 | Is covid-19 induced anosmia caused by disruption of nuclear architecture? | Disruption of nuclear architecture as a cause of COVID-19 induced anosmia., Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components... | yes |
converted_3608 | Is amantadine ER the first approved treatment for akinesia? | Extended-release amantadine (amantadine ER) is the first approved medication for the treatment of dyskinesia.[SEP]Relations: genetic syndromic Pierre Robin syndrome has relations: disease_disease with tarp syndrome, disease_disease with tarp syndrome, disease_disease with Pierre Robin syndrome associated with branchial... | no |
converted_2552 | Is the consumption of chocolate associated with an increase in cardiovascular disease? | The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke., chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties., A number of studies have shown that dietary polyphen... | no |
converted_4061 | Is acupotomy used to treat muscle stiffness? | All the included studies reviewed musculoskeletal disorders and reported a significantly higher total effective and cure rates in the acupotomy group for frozen shoulder, cervical spondylosis, third lumbar vertebrae transverse process syndrome, trigger finger, knee osteoarthritis, and lumbar spinal stenosis, compared t... | no |
converted_2009 | Can Pentraxin 3 predict outcomes of sepsis? | As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. , Neonates with high nPTX3 concentrations also have lowered... | yes |
converted_1745 | Are microtubules marked by glutamylation? | Together with detyrosination, glutamylation and other modifications, tubulin acetylation may form a unique 'language' to regulate microtubule structure and function., Glutamylation, the most prevalent tubulin posttranslational modification, marks stable microtubules and regulates recruitment and activity of microtubule... | yes |
converted_3500 | Does deletion of cohesin change gene expression? | The conditional deletion of cohesin from noncycling thymocytes preserved enhancer position, H3K27ac, H4K4me1, and enhancer transcription, but weakened interactions between enhancers., Interestingly, ∼ 50% of deregulated genes reside in the vicinity of enhancer elements, suggesting that cohesin regulates gene expressio... | yes |
converted_2464 | Is Marfan syndrome associated with chordal rupture? | Repair of the mitral valve in children who have Marfan syndrome is especially difficult due to the presence of generalized connective tissue disorder, which may lead to future elongation and rupture of chordae tendineae that were unaffected at the time of mitral valve repair., Mitral regurgitation was caused by annulus... | yes |
converted_4628 | Is tirabrutinib effective for lymphoma? | In March 2020, oral tirabrutinib was approved in Japan for the treatment of recurrent or refractory primary central nervous system lymphoma. Tirabrutinib is also under regulatory review in Japan for the treatment of Waldenström's macroglobulinemia and lymphoplasmacytic lymphoma. Clinical development is underway in the ... | yes |
converted_1369 | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
converted_182 | Does thyroid hormone regulate calcium transient in the myocardium? | 3-iodothyronamine (T(1)AM) is a novel endogenous relative of thyroid hormone, able to interact with trace amine-associated receptors, a class of plasma membrane G protein-coupled receptors, and to produce a negative inotropic and chronotropic effect, In adult rat cardiomyocytes acute exposure to 20 microM T(1)AM decrea... | yes |
converted_360 | Have thyronamines effects on fat tissue? | In conclusion, trace amines and thyronamines are negative inotropic agents., Their in vivo administration induces effects opposite to those induced by thyroid hormone, including lowering of body temperature.[SEP]Relations: response to thyroid hormone has relations: bioprocess_protein with GBA, bioprocess_protein with G... | no |
converted_4611 | Has CPX-351 been approved by the FDA and the EMA? | CPX-351 (United States: Vyxeos®; Europe: Vyxeos® Liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, is approved by the US FDA and the EMA for the treatment of adults with newly diagnosed therapy-related acute myeloid leukemia or acute myeloid leukemia with m... | yes |
converted_4184 | Are interferons defensive proteins? | In response to viral infections, various pattern recognition receptors (PRRs) are activated for the production of type I interferon (IFN I). , activating interferon (IFN) production and positively regulating antiviral response in mammals. , The innate immune system, in particular the type I interferon (IFN) response, ... | yes |
converted_523 | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC., Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass ... | yes |
converted_3132 | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | Predicting Functions of Disordered Proteins with MoRFpred., Intrinsically disordered proteins and regions are involved in a wide range of cellular functions, and they often facilitate protein-protein interactions. Molecular recognition features (MoRFs) are segments of intrinsically disordered regions that bind to partn... | yes |
converted_74 | Do patients with Pendred syndrome present congenital deafness? | Pendred Syndrome can be characterized by the triad composed of familial goitre, abnormal perchlorate discharge and congenital deafness., Pendred syndrome is an autosomal recessive disorder characterized by congenital deafness and goiter. , Pendred syndrome comprises congenital sensorineural hearing loss, thyroid goiter... | yes |
converted_2570 | Is pregabalin effective for sciatica? | CONCLUSIONS: Treatment with pregabalin did not significantly reduce the intensity of leg pain associated with sciatica and did not significantly improve other outcomes, as compared with placebo, over the course of 8 weeks. The incidence of adverse events was significantly higher in the pregabalin group than in the plac... | no |
converted_2394 | Does erythromycin increase risk of hypertrophic pyloric stenosis? | Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis., PURPOSE: Macrolide antibiotics, erythromycin, in particular, have been linked to the development of infantile hypertrophic pyloric stenosis (IHPS)., Overall, erythromycin exposure was significa... | yes |
converted_419 | Are there transposon-free regions in mammalian genomes? | Transposon-free regions in mammalian genomes., Despite the presence of over 3 million transposons separated on average by approximately 500 bp, the human and mouse genomes each contain almost 1000 transposon-free regions (TFRs) over 10 kb in length. The majority of human TFRs correlate with orthologous TFRs in the mous... | yes |
converted_3486 | Are there lncRNAs that control the extent of neuronal outgrowth? | Regulation of Neuroregeneration by Long Noncoding RNAs., Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the exten... | yes |
converted_508 | Does cortical spreading depression appear in ischemic penumbra following ischemic stroke? | During the subacute phase, the irreversible damage expands into the penumbra: multiple electrical and biological signals are triggered by periinfarct, spreading depression-like depolarizations leading to hypoxia and stepwise increase in lactate., Experimental and clinical studies indicate that waves of cortical spreadi... | yes |
converted_4444 | Can epigenetic modifications be heritable? | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. [SEP] | yes |
converted_3970 | Does erenumab target the calcitonin gene-related peptide? | Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab).[SEP]Relations: CALCRL has relations: drug_protein with Erenumab, drug_protein with Erenumab, molfun... | no |
converted_4366 | Is there a genetic cause of craniostenosis? | Apert syndrome - acrocephalosyndactyly - is a rare autosomal dominant disorder representing 1:65 000 cases of living newborns. Characteristic malformations of the Apert syndrome are early craniostenosis, microviscerocranium and II-V finger syndactyly of hand and toes with proximal phalanx of the bilateral thumb "in del... | yes |
converted_292 | Is RET the major gene involved in Hirschsprung disease? | The RET proto-oncogene is the major gene associated to HSCR with differential contributions of its rare and common, coding and noncoding mutations to the multifactorial nature of this pathology, The RET proto-oncogene is the major gene for HSCR with differential contributions of its rare and common, coding and noncodin... | yes |
converted_3555 | Is AZD5153 active in prostate cancer? | AZD5153 Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo., Bromodomain-containing protein 4 (BRD4) overexpression participates in prostate cancer progression by enhancing the transcriptional activity and expression of several key oncogenes. AZD5153 is a novel BRD4 inhibitor.METHODS: Prostate cancer cells were ... | yes |
converted_3849 | Can ATAC-Seq be employed in single-cell mode? | Single-cell ATAC-seq: strength in numbers., Assembly, and Single-Cell ATAC-Seq., Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement., Here, we comprehensively characterize mouse cardiac progenitor cells (CPCs) marked by Nkx2-5 and Isl1 expression from E7.5 to ... | yes |
converted_539 | Are integrins part of the extracellular matrix? | Several constituents of the ECM provide adhesive cues, which serve as binding sites for cell trans-membrane receptors, such as integrins., We also determined that blocking β1integrins, the major class of receptors for all ECM proteins tested,, Here, we elucidate a cross-scale mechanism for tissue assembly and ECM remod... | yes |
converted_4449 | Is Belimumab used for lupus nephritis? | In particular, depletion (Obinutuzumab, anti-CD20 monoclonal antibody) or neutralization (Belimumab, anti-"B-cell activating factor" monoclonal antibody) of B lymphocytes, and the use of a calcineurin inhibitor with a low profile of renal and systemic toxicity (Voclosporin) demonstrated an improvement in renal response... | yes |
converted_3359 | Is the FIP virus thought to be a mutated strain for the Feline enteric Coronavirus? | Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection., It is caused by FIP virus (FIPV), a virulent mutant strain of Feline Enteric Coronavirus (FECV)., Feline infectious peritonitis virus (FIPV) was presumed to arise from mutations i... | yes |
converted_836 | Is there any functional association during viral replication between flaviviridae viral RNA depended RNA polymerase and viral helicase? | Several labs have obtained evidence for a protein complex that involves many of the nonstructural (NS) proteins encoded by the virus. NS3, NS4A, NS4B, NS5A, and NS5B appear to interact structurally and functionally. In this study, we investigated the interaction between the helicase, NS3, and the RNA polymerase, NS5B. ... | yes |
converted_697 | Are there randomised controlled trials on sevoflurane? | After Ethics Review Board approval, 44 ASA I-III patients undergoing elective gynaecological surgery were randomised after surgery to either hypercapnic hyperpnoea or control groups., Hypercapnic hyperpnoea in spontaneously breathing patients halves the time of recovery from sevoflurane-induced anaesthesia in the opera... | yes |
converted_3701 | Have toll-like receptor 2 activators been found in food? | Toll-like receptor 2 (TLR2) is a widely expressed pattern recognition receptor critical for innate immunity. TLR2 is also a key regulator of mucosal immunity implicated in the development of allergic disease. TLR2 activators are found in many common foods,, TLR2 activators are found in many common foods, but the role o... | yes |
converted_3445 | Does radiation for tinea capitis increases brain tumor risk? | Emphasis is placed on meningiomas resulting from childhood treatment for primary brain tumor or tinea capitis, exposure to dental x-rays, and exposure to atomic explosions in Hiroshima and Nagasaki. , It is well known that radiation can induce meningiomas. These tumors usually arise in patients with a history of low-do... | yes |
converted_347 | Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Z ∼ 1/X in genomes. The most powerful test is a new non-parametric one based upon the correlation ratio, which is able to reject Z ∼ 1/X in nine... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_4475 | Is Acute Necrotizing Encephalopathy (ANE) which typically affects young, healthy children usually triggered by exposure to air pollution? | Acute necrotizing encephalopathy (ANE) is a recently identified, uncommon encephalopathy affecting children. ANE is characterized by a preceding viral illness followed by seizures and rapid progressive neurologic deterioration. , Acute necrotizing encephalopathy (ANE) is a specific type of encephalopathy usually follow... | no |
converted_2171 | Is tirilazad effective for treatment of aneurysmal subarachnoid haemorrhage? | There was no significant difference between the two groups at the end of follow up for the primary outcome, death (odds ratio (OR) 0.89, 95% confidence interval (CI) 0.74 to 1.06), or in poor outcome (death, vegetative state or severe disability) (OR 1.04, 95% CI 0.90 to 1.21). During the treatment period, fewer patien... | no |
converted_874 | Is cystatin C or cystatin 3 used as a biomarker of kidney function? | to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes., Cystatin C, a more specific kidney function biomarker, was also elevated at 24 h after CLP., This study evaluated FGF-23 as well as traditi... | yes |
converted_3239 | Is TNF-α an activator of pancreatic stellate cells? | TNF-α is the prime factor responsible for the activation of pancreatic stellate cells, Activated PSCs expressed IL-33 in the nucleus, and the expression was increased by IL-1β, TNF-α, PDGF-BB, and IFN-γ, but not TGF-β1. [SEP]Relations: pancreatic stellate cell proliferation has relations: bioprocess_bioprocess with fib... | yes |
converted_2004 | Are there methods for generating highly multiplexed ChIP-seq libraries? | A method for generating highly multiplexed ChIP-seq libraries., The barcoding of next generation sequencing libraries has become an essential part of the experimental design. Barcoding not only allows the sequencing of more than one sample per lane, but also reduces technical bias. However, current barcoding strategies... | yes |
converted_4279 | Are variants in FHF2 (also known as FGF13) associated with encephalopathy? | Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy., Whole-exome sequencing identified hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A). The X-linked FHF2 gene (also known as FGF13) has alternati... | yes |
converted_4535 | Is there a way to distinguish COVID-19 clinically from other respiratory illnesses, particularly influenza? | Findings indicate that clinical symptoms alone would be insufficient to distinguish between coronavirus disease 2019 and other respiratory infections (eg, influenza) and/or to evaluate the effects of preventive interventions (eg, vaccinations)., Our reasoning highlights how challenging a balanced approach to a patient ... | no |
converted_2617 | Is there a link between nuclear position and DNA repair pathway choice? | Nuclear position dictates DNA repair pathway choice., We demonstrate that DSBs induced at the nuclear membrane (but not at nuclear pores or nuclear interior) fail to rapidly activate the DNA damage response (DDR) and repair by homologous recombination (HR). Real-time and superresolution imaging reveal that DNA DSBs wit... | yes |
converted_3290 | Are ICAMS, Intracellular Adhesion Molecules, part of the immunoglobulin superfamily? | It has now been shown that adhesion molecules, particularly those of the immunoglobulin super family (e.g. ICAM-1, VCAM-1 and PECAM-1),, Intercellular adhesion molecule 3 (ICAM-3, also known as CD50), a human leukocyte-restricted immunoglobulin super-family (IgSF) member, has previously been implicated in apoptotic ce... | yes |
converted_2216 | Is Hepatic mesenchymal hamartoma usually a malignant tumor? | Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, , Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age, This review on the pathology of hepatic tumors in childhood, from a personal series of 245 tumors, focuses on in... | no |
converted_72 | Are transcribed ultraconserved regions involved in cancer? | Although most cancer research has focused in mRNA, non-coding RNAs are also an essential player in tumorigenesis. In addition to the well-recognized microRNAs, recent studies have also shown that epigenetic silencing by CpG island hypermethylation of other classes of non-coding RNAs, such as transcribed ultraconserved ... | yes |
converted_4694 | Are there any R packages that help with visualizing data on spirals? | spiralize: an R package for Visualizing Data on Spirals., Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here we present t... | yes |
converted_4037 | Is Tocilizumab (Actemra) used to block/antagonize the IL-6 receptor? | Preliminary clinical results have indicated that antagonism of the IL-6 receptor (IL-6R), including with the FDA-approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID-19 while maintaining a good safety profile., Tocilizumab, an anti-IL-6 receptor antibody... | yes |
converted_2562 | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. , Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk f, Subacute sclerosing panencephalitis should be eliminated by measles vaccination, T... | no |
converted_299 | Has the protein SETMAR (Metnase) a transposase domain? | Metnase (SETMAR) is a SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair in humans., The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations., Metnase (also termed SETMAR) is a fusion of a histone methylase and transposase protein that arose specifically in... | yes |
converted_3273 | Has the drug Afrezza been approved by the FDA? | In contrary, MannKind Corporation started developing its ultra-rapid-acting insulin Afrezza in a bold bid, probably by managing the issues in which Exubera was not successful. Afrezza has been marketed since February, 2015 by Sanofi after getting FDA approval in June 2014.[SEP] | yes |
converted_4419 | Is Sotatercept effective for Pulmonary Arterial Hypertension? | Sotatercept for the Treatment of Pulmonary Arterial Hypertension., CONCLUSIONS: Treatment with sotatercept resulted in a reduction in pulmonary vascular resistance in patients receiving background therapy for pulmonary arterial hypertension., Sotatercept for the Treatment of Pulmonary Arterial Hypertension, CONCLUSIONS... | yes |
converted_1122 | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism., Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis, This is the first case of germline mosaicism in tuberous ... | yes |
converted_4125 | Is vocimagene amiretrorepvec effective for glioblastoma? | CONCLUSIONS: These results support an immune-related mechanism of action for Toca 511 and Toca FC, and suggest that molecular and immunologic signatures are related to clinical benefit from treatment., The median OS was 11.10 months for the Toca 511/FC group and 12.22 months for the control group (hazard ratio, 1.06; 9... | no |
converted_1176 | Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | In addition, IL-6 concentrations affect clinical outcomes in ischemic stroke., After appropriate adjustment, the odds ratios for the association of markers and poor outcome (comparing the upper and the lower third) were interleukin-6, 3.1 (95% CI: 1.9-5.0); C-reactive protein, 1.9 (95% CI: 1.2-3.1); fibrinogen, 1.5 (9... | yes |
converted_390 | Does PU.1 (SPI1) affect NF-kB binding? | Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs)., Within 1217 bp of upstream sequence, 3 sites for N... | yes |
converted_2274 | Is autophagy modulated in a circadian fashion? | TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster., Our results indicate that the TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in the behavior and plast... | yes |
converted_2129 | Is diphosphatidylglycerol (cardiolipin) a phospholipid of the mitochondrial membranes? | A unique organelle for studying membrane biochemistry is the mitochondrion whose functionality depends on a coordinated supply of proteins and lipids. Mitochondria are capable of synthesizing several lipids autonomously such as phosphatidylglycerol, cardiolipin and in part phosphatidylethanolamine, phosphatidic acid an... | yes |
converted_2663 | Is the petrous bone used in ancient DNA sampling? | Large-scale genomic analyses of ancient human populations have become feasible partly due to refined sampling methods. The inner part of petrous bones and the cementum layer in teeth roots are currently recognized as the best substrates for such research., Ancient DNA (aDNA) research involves invasive and destructive s... | yes |
converted_8 | Has Denosumab (Prolia) been approved by FDA? | Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors., The authors present the imaging findings and technical report of an attempted percutaneous vertebroplasty in the only patient found to be actively under... | yes |
converted_1519 | Does nifedipine inhibit L-type calcium channels? | Nifedipine, an L-type calcium channel blocker, reduced the expression of synaptogamin and syntaxin and blocked the suppressive effect of vecuronium, suggesting that both agents inhibit presynaptic L-type calcium channels., Treatment with nifedipine to inhibit calcium influx via the L-type channel Cav1.2 (alpha(1C)) inh... | yes |
converted_530 | Is there an association between bruxism and reflux | Rhythmic masticatory muscle activity, including sleep bruxism (SB), can be induced in healthy individuals by experimental esophageal acidification, which plays an important role in the pathogenesis of gastroesophageal reflux disease (GERD). However, no robust evidence supports the association between SB and GERD., Slee... | yes |
converted_4634 | Is HDAC1 required for GATA-1 transcriptional activity? | HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis., GATA-12RA knock-in (KI) mice suffer mild anemia and thrombocytopenia with accumulation of immature erythrocytes and megakaryocytes in bone marrow and spleen. Single cell RNA-seq analysis of Lin- cKit+ (LK) cells further ... | yes |
converted_4512 | Does p85α homodimerize? | homodimerized p85α, p110α-free p85α homodimerizes, homodimeric but not monomeric p85α[SEP] | yes |
converted_1238 | Is the Snord116 cluster associated with the Prader-Willi syndrome? | All three deletions included SNORD116, but only two encompassed parts of SNURF-SNRPN, implicating SNORD116 as the major contributor to the Prader-Willi phenotype. Our case adds further information about genotype-phenotype correlation and supports the hypothesis that SNORD116 plays a major role in the pathogenesis of Pr... | yes |
converted_3008 | Can Diazepam be beneficial in the treatment of traumatic brain injury? | he present experiment examined the effects of diazepam, a positive modulator at the GABA(A) receptor, on survival and cognitive performance in traumatically brain-injured animals. I[SEP]Relations: Diazepam has relations: drug_effect with Memory impairment, drug_effect with Memory impairment, drug_effect with Loss of co... | yes |
converted_1329 | Is p100 the precursor protein molecule of the NF-kappaB transcription factor subunit p50? | We previously reported that alymphoplasia (aly/aly) mice, which have a natural loss-of-function mutation in the Nik gene, which encodes a kinase essential for the processing of p100 to p52 in the alternative nuclear factor-κB (NF-κB) pathway, show mild osteopetrosis with an increase in several parameters of bone format... | no |
converted_767 | Is tubulin acetylation involved in cell motility? | In this study, we found that paclitaxel induced tubulin acetylation in endothelial and tumor cells, at concentrations that affected cell motility but not proliferation (10(-8) to 10(-9) M, for 4 hours). Induction of tubulin acetylation correlated with inhibition of motility but not proliferation based on a comparison o... | yes |
converted_1255 | Is lenvatinib effective for thyroid cancer? | New insights in the treatment of radioiodine refractory differentiated thyroid carcinomas: to lenvatinib and beyond., However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was con... | yes |
converted_1082 | Are there any Decision support systems for chronic pain management ? | a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS), We based the DSS on the existing ATHENA-DSS, Use of this iterative process led to development of a multifunctional DSS, interactive decision dashboard... | yes |
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