id stringlengths 11 14 | sentence1 stringlengths 20 168 | sentence2 stringlengths 55 19.7k | label stringclasses 2
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converted_790 | Is recommended the use of perioperative treatment with thyroid hormone therapy in patients undergoing coronary artery bypass grafting? | Short duration postoperative iv T(3) therapy increases cardiac index and does not alter mortality., We conclude that although widespread interest has been shown on the use of thyroid hormones in the perioperative period, and the effect of cardiopulmonary bypass on thyroid hormone metabolism widely studied, there is no ... | no |
converted_3145 | Can TAD disruption lead to disease? | its perturbation will lead to human disease, highlighting the accumulating evidence that links the diverse 3D genome architecture components to a multitude of human diseases and the emerging mechanisms by which 3D genome derangement causes disease phenotypes., TAD boundaries are insulators of genomic neighborhoods. In ... | yes |
converted_3854 | Are super enhancers structurally insulated in chromatin loops? | Dissecting super-enhancer hierarchy based on chromatin interactions, Genetic ablation of hub enhancers results in profound defects in gene activation and local chromatin landscape., We also demonstrate that the Wap super-enhancer, which is built on STAT5 and other common transcription factors, retains its exquisite mam... | no |
converted_1171 | Is nicotinamide effective for skin cancer prevention? | Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses., ESULTS: At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% (95% confidence interval [CI], 4 to 38) in the nicotinamide group than ... | yes |
converted_1878 | Is there alternative polyadenylation during zebrafish development? | Extensive alternative polyadenylation during zebrafish development., At 2 h post-fertilization, thousands of unique poly(A) sites appear at locations lacking a typical polyadenylation signal, which suggests a wave of widespread cytoplasmic polyadenylation of mRNA degradation intermediates. Our insights into the identit... | yes |
converted_4040 | Is there an upper limit on the functional fraction of the human genome? | Mutational load considerations lead to the conclusion that the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower.[SEP] | yes |
converted_3960 | Is avelumab effective for urothelial carcinoma? | ince then, additional checkpoint inhibitors, including avelumab, durvalumab, and nivolumab, have gained approval. , Avelumab, an anti-programmed death-ligand 1 monoclonal antibody approved for the treatment of metastatic Merkel cell carcinoma and platinum-treated urothelial carcinoma, was initially approved with a 10 m... | yes |
converted_2832 | Is durvalumab used for lung cancer treatment? | In the phase III PACIFIC trial consolidation with durvalumab, an anti-PDL-1 antibody, was associated with survival benefit in patients diagnosed with LA-NSCLC who responded to concurrent chemoradiotherapy., METHODS: An electronic literature search was performed of public databases (MEDLINE, Excerpta Medica dataBASE [E... | yes |
converted_1411 | Is the ACE inhibitor indicated for lung cancer treatment? | The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease the risk of some cancers, although available data are conflicting. , Using cell viability and fluorescent activated cell sorting analysis tests, we demonstrated that captopril inhi... | no |
converted_2933 | Is there a deep-learning algorithm for protein solubility prediction? | DeepSol: a deep learning framework for sequence-based protein solubility prediction., Protein solubility plays a vital role in pharmaceutical research and production yield. For a given protein, the extent of its solubility can represent the quality of its function, and is ultimately defined by its sequence. Thus, it is... | yes |
converted_1596 | Have thyronamines effects on fat tissue? | Intraperitoneal or central injection of 3-T(1)AM or T(0)AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. [SEP]Relations... | yes |
converted_3375 | Are breaks in double stranded DNA associated with ionizing radiation? | DNA double-strand breaks (DSBs) are major DNA lesions that are constantly formed during physiological processes such as DNA replication, transcription, and recombination, or as a result of exogenous agents such as ionizing radiation, radiomimetic drugs, and genome editing nucleases, Whereas most endogenous and exogenou... | yes |
converted_4422 | Is pRETRO-SUPER an adenoviral vector? | In this study, we investigated the effect of small interfering RNA (siRNA) of connective tissue growth factor (CTGF) by pRetro-Super (PRS) retrovirus vector on the expression of CTGF and related extracellular matrix molecules in human renal proximal tubular cells (HKCs) induced by high glucose, to provide help for ren... | no |
converted_2207 | Is Prochlorococcus the most abundant photosynthetic organism? | The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth., The marine cyanobacterium Prochlorococcus is the numerically dominant photosynthetic organism in the oligotrophic oceans, and a model system in marine microbial ecology., The marine cyanobacterium Prochlorococ... | yes |
converted_1187 | Is there any link between conserved noncoding elements and alternative splicing in vertebrates? | Some of the most highly conserved sequences occur in genes encoding RNA binding proteins, particularly the RNA splicing-associated SR genes. Differences in sequence conservation between plants and animals are likely to reflect differences in the biology of the organisms, with plants being much more able to tolerate gen... | yes |
converted_909 | Does resveratrol reduce cardiac remodeling? | In conclusion, resveratrol attenuated cardiac oxidative damage and left ventricular remodeling and enhanced the decreased expression of SIRT1 in hearts of old rats with emphysema and thus might be a therapeutic modality for cardiac injury complicated in chronic obstructive pulmonary disease (COPD)., In conclusion, resv... | yes |
converted_249 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by xerostomia and altered taste., It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, lips, and hard and soft palate. , BMS is a chronic disorder that frequently ... | yes |
converted_4250 | Is Ozanimod effective for Ulcerative Colitis? | Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis., CONCLUSIONS: Ozanimod was more effective than placebo as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis., CONCLUSIONS: There was a high rate of continued study participation and long-term benefit ... | yes |
converted_3387 | Has ZP-PTH been tested in a phase II clinical trial? | This system was successfully tested in a Phase 2 clinical trial for the treatment of post-menopausal women with osteoporosis.[SEP]Relations: stenosis or atrophy of the coronary ostium has relations: disease_disease with abnormal origin or aberrant course of coronary artery, disease_disease with abnormal origin or aberr... | yes |
converted_1853 | Could hypophosphatemic rickets cause craniosynostosis? | This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. , Hypophosphatemic rickets and craniosynostosis: a multicenter case series., A 20-year retrospective review identified patients with hypophosphatemic ric... | yes |
converted_1664 | Is the protein FAK (Focal Adhesion Kinase) phosphorylated? | Overexpression of NEDD9 led to tyrosine phosphorylation of FAK and SRC oncoproteins, , yrosine phosphorylated FAK, TNFα contributes for attenuating both Y397FAK and Y416Src phosphorylations in osteoblasts., It was possible to show that TNFα provokes attenuation at Y-phosphorylation of both FAK (at Y397 ), ownregulatio... | yes |
converted_3898 | Can saponins be used as adjuvant? | We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants, The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate, BALB/c mice immunized with subcutaneous injections of the recombinant protein... | yes |
converted_2965 | There is no drug available to prevent HIV infection, Pre-exposure prophylaxis (PrEP), yes or no? | pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London - analysis of pharmacokinetics, safety and outcomes., The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also ... | no |
converted_3855 | Does IL18 signaling have a role in thymus? | IL18 signaling promotes homing of mature Tregs into the thymus., Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus., er, we show that IL18R+ T... | yes |
converted_3947 | Is there a link between rare variants in PPARG and type 1 diabetes? | Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes., By sequencing PPARG in 19,752 T2D cases and controls drawn from multiple studies and ethnic groups, we identified 49 previously unidentified, nonsynonymous PPARG variants (MAF < 0.5%). Con... | no |
converted_3339 | Can MVA85A confer immunity against smallpox? | We assessed the safety, immunogenicity, and efficacy of a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults infected with HIV-1., Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised,... | no |
converted_4667 | Is Ameloblastoma (AB) a common benign tumor occurring in the brain? | Ameloblastoma is a benign odontogenic tumor which undergoes malignant transformation to ameloblastic carcinoma. , Ameloblastomas are benign tumors that most commonly affecting the mandible. , Ameloblastoma is a neoplasm arising in the craniofacial skeleton., Ameloblastoma is an invasive odontogenic tumor, and for recon... | no |
converted_2959 | Is Adar3 involved in learning and memory? | Adar3 Is Involved in Learning and Memory in Mice., The newest member of the A-I editing family of ADAR proteins, the vertebrate-specific ADAR3, is highly expressed in the brain, but its functional significance is unknown. In vitro studies have suggested that ADAR3 acts as a negative regulator of A-I RNA editing but th... | yes |
converted_1551 | Can we use platelet biomarkers to study Alzheimer's disease? | Platelet biomarkers in Alzheimer's disease., platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B., Alternative plasma and platelet measures are described,, The success of these studies led to the applicati... | yes |
converted_24 | Is Alu hypomethylation associated with breast cancer? | Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer, In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status, In survival analyses, low Alu methylation status tended to be associated with poor disease-free survival of the patients., Alu hypomethylation is ... | yes |
converted_2205 | Does the Abelson-related gene (ARG) gene encode for a serine kinase? | One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton., The non-receptor tyrosine kinase Abelson related gene (Arg/Abl2) regulates cell migration and morphogenesis by modulating the cytoskeleton. , The human Arg (Abl... | no |
converted_995 | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification, gfi1aa and gfi1b have distinct roles in regulating primitive and d... | yes |
converted_996 | Has Revlimid been approved by the US Food and Drug Administration? | In the past decade, immunomodulatory drugs have been approved by the US Food and Drug Administration for the treatment of multiple myeloma (MM)-and a number of emerging agents that target the cellular pathways or proteins involved in the pathophysiology of MM are currently in development. Lenalidomide (Revlimid) and po... | yes |
converted_3875 | Is MK-1602 a CGRP antagonist? | The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine., This trial supports ubrogepant's efficacy and provides further evidence that CGRP-RAs are viable options for the acute treat... | yes |
converted_4138 | Is methotrexate used for the treatment of Rheumatoid Arthritis (RA)? | The use of methotrexate in rheumatoid arthritis., Historical perspective on the use of methotrexate for the treatment of rheumatoid arthritis., Aminopterin, a folic acid analogue was first reported in 1948 to produce temporary remission of acute leukemia of children, was also reported in 1951 to produce an important an... | yes |
converted_811 | Is myasthenia gravis associated with osteoporosis? | We performed PVP in 4 patients with generalized MG associated with recent steroid-induced symptomatic VFs. , In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis., INTRODUCTION: ... | yes |
converted_2244 | Does RNA polymerase II have RNA cleavage activity? | In addition to RNA synthesis, multisubunit RNA polymerases (msRNAPs) support enzymatic reactions such as intrinsic transcript cleavage., msRNAP active sites from different species appear to exhibit differential intrinsic transcript cleavage efficiency and have likely evolved to allow fine-tuning of the transcription pr... | yes |
converted_3234 | Anaplasma phagocytophilum is an obligate gram-negative, intracellular bacterium, yes or no | The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. ... | yes |
converted_4608 | Is Benralizumab effective for Chronic Spontaneous Urticaria? | Finally, treatments aimed at reducing eosinophil accumulation and activation, such as the anti-IL-5 antibodies mepolizumab, reslizumab, and benralizumab, have been reported to reduce CSU symptoms. , The treatments that are under clinical trials for CSU are anti-IgE treatments such as ligelizumab, molecules targeting in... | yes |
converted_2558 | Is the gene CDKN2A nevogenic? | Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts., Phenotypic characteristics of members of a melanoma prone kindred with a V126D CDKN2A gene mutation were monitored over approximately 15 y., Rare germline mutations in CDKN2A predisp... | yes |
converted_2096 | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. , Cryptococcus is a ubiquitous fungus and is k... | no |
converted_4439 | Are circular RNAs implicated in diseases of the eye? | n this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment., This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative d... | yes |
converted_445 | Is there any relationship between histone ubiquitylation and splicing? | histone H2B-specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons., H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae, H2B ubiquitination by facilitating splicing, pre-mRNA splicing plays a crit... | yes |
converted_4604 | Is Daprodustat effective for anemia? | CONCLUSIONS: Oral daprodustat was noninferior to CERA in achieving and maintaining target hemoglobin levels in Japanese ND patients. , BACKGROUND: The Anemia Studies in chronic kidney disease (CKD): Erythropoiesis via a Novel prolyl hydroxylase inhibitor (PHI) Daprodustat-Dialysis (ASCEND-D) trial will test the hypothe... | yes |
converted_1452 | Does dronedarone affect T3 and T4 levels? | Amiodarone resulted in increased T4, T4/T3 and rT3, whereas dronedarone did not alter the thyroid hormone profile in normal animals., Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17)., Thyroid function was ... | no |
converted_1543 | Is there a mouse model for Fanconi anemia? | Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities, We compared Cy preconditioning with fludarabine (Flu) or cytarabine (AraC) or no conditioning as a control in fanca ( -/- ) mutant mice receiving gene-modified bone marrow cells, We... | yes |
converted_213 | Is protein M3/6 a dual specificity phosphatase? | Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus., The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi. , This study examines the molecular mechanism... | yes |
converted_2016 | Is ocular melanosis a risk factor for uveal melanoma? | Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 in 400 affected patients., Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 ... | yes |
converted_2308 | Is there an RNAi drug being developed to treat amyloidosis? | Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality.[SEP]Relations: primary amyloidosis has relations: disease_disease with AL amyloidosis, dise... | yes |
converted_1237 | Has the protein GFP been used in transgenesis for live protein imaging? | we review recent advancement in the functional studies of the three different GnRH neuron systems, mainly focusing on the electrophysiological analysis of the GnRH-green fluorescent protein (GFP) transgenic animals., founders were found to be transgenic for GFP., GFP expression was detected in a wide range of murine ti... | yes |
converted_4370 | Is hemoglobin antimicrobial? | the α137-141 peptide, a natural antimicrobial peptide, can be obtained after hydrolysis of hemoglobin, the main constituent of blood red part, Beyond its physiological activity, hemoglobins are able to inhibit the growth of several microorganisms., A novel AMP, T. granosa hemoglobin-derived peptide (TGH1), was identifi... | yes |
converted_3115 | Is lactotransferrin a tumour suppressor? | LTF (lactotransferrin, or lactoferrin) plays important role in innate immunity, and its anti-tumor function has also been reported in multiple cancers., We previously reported that LTF is significantly down-regulated in nasopharyngeal carcinoma (NPC) and acts as a tumor suppressor by suppressing AKT signaling., The tum... | yes |
converted_1131 | Do conserved noncoding elements co-occur with matrix-attachment regions? | We hypothesized that some of these regions might be matrix-scaffold attachment regions, MARs (or S/MARs). MARs comprise one of the few classes of eukaryotic noncoding DNA with an experimentally characterized function, being involved in the attachment of chromatin to the nuclear matrix, chromatin remodeling and transcri... | yes |
converted_818 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury., Treatment with T3 (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. , Western blot analysis reve... | yes |
converted_1267 | Does HER2 under-expression lead to favorable response to trastuzumab? | over-expression of HER2 is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. , In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. Addition of... | no |
converted_3280 | Is Protoporphyrinogen oxidase localized to the mitochondrium? | We showed that 28 amino acids in the amino terminus of PPOX contain an independently functioning signal for mitochondrial targeting., Based on our results we propose a mechanism for protoporphyrinogen oxidase targeting to the mitochondrion., Mitochondrial targeting of human protoporphyrinogen oxidase., In the present s... | yes |
converted_3620 | Are tumour specific antigens originating from known protein coding genes? | It is well established that MHC class I molecules present peptides from endogenous proteins, such as virus or tumour antigens, to CD8+ T lymphocytes. , So far, human tumour specific antigens that can be presented by HLA molecules have not been identified on the molecular level., These CTLs recognize short peptides deri... | yes |
converted_3090 | Is eculizumab used for treatment of myasthenia gravis? | Eculizumab treatment improved symptoms compared with placebo in a phase II study in patients with refractory gMG. D, Eculizumab (Soliris) has been approved in several countries for refractory forms of generalized seropositive severe myasthenia gravis. , The humanized monoclonal antibody eculizumab (Soliris®) is a compl... | yes |
converted_2421 | Is patisiran currently (November 2017) in clinical phase II trials? | This review addresses nine small-interfering RNAs (siRNAs) and one unique microRNA (miRNA) inhibitor, which entered the phase 2-3 clinical trials. The siRNAs in focus are PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). , patisiran (phase 3), Ph... | no |
converted_4699 | Are there roles for cohesin mutations in AML? | Several landmark studies have shown that cohesin mutations perturb the balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPC). Emerging data now begin to uncover the molecular mechanisms that underpin this phenotype. Among these mechanisms is a role for cohesin in the control... | yes |
converted_1899 | Have the promoter regions of the genes implicated in Rett Syndrome been characterized with CAGE? | CAGE-defined promoter regions of the genes implicated in Rett Syndrome., Mutations in three functionally diverse genes cause Rett Syndrome. Although the functions of Forkhead box G1 (FOXG1), Methyl CpG binding protein 2 (MECP2) and Cyclin-dependent kinase-like 5 (CDKL5) have been studied individually, not much is known... | yes |
converted_214 | Are there focused databases from which you can retrieve gene expression data on renal disease? | Proteomics database in chronic kidney disease, Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease[SEP]Relations: Chronic kidney disease has relations: disease_phenotype_positive with glycogen storage disease, disease_phenotype_positive with glycogen storage disease, disease_phenot... | yes |
converted_1325 | Do all archaea possess multiple origins of DNA replication? | Origins differ in number and structure across the three domains of life and their properties determine the dynamics of chromosome replication. Bacteria and some archaea replicate from single origins, whereas most archaea and all eukaryotes replicate using multiple origins., Replication starts at a single Ori site in ba... | no |
converted_3144 | Is the protein Asporin related to disease? | Accumulating evidence demonstrates the involvement of asporin in OA pathogenesis., Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer., Asporin has been implicated as an oncogene in various types of human cancers; , These results sugg... | yes |
converted_2024 | Is the enzyme EPRS phosphorylated? | Phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) has been investigated extensively in our laboratory for more than a decade, and has served as an archetype for studies of other AARSs., EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by a Cdk5-dependent-AGC kinase at Ser(9... | yes |
converted_4112 | Is there a role for TFII-I in megakaryopoiesis? | TFII-I/Gtf2i and Erythro-Megakaryopoiesis., TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizyg... | yes |
converted_1125 | Does smoking increase risk for glioblastoma? | Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility., No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of... | no |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_957 | Is selenium deficiency involved in autoimmune thyroid disease? | In areas with severe selenium deficiency higher incidence of thyroiditis has been reported due to a decreased activity of selenium-dependent glutathione peroxidase enzyme within thyroid cells, Of 30 patients in the selenium treated group, 6 patients were overtly hypothyroid, 15 were subclinical hypothyroid, 6 were euth... | yes |
converted_785 | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder., Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.... | yes |
converted_3449 | Can Flotillin be used as exosomal marker? | Flotillin 1 and tumor susceptibility gene 101 (TSG101), two exosomal marker proteins, , expressed exosomal marker tumor susceptibility gene (TSG) 101 and flotillin (Flot) 1.[SEP]Relations: Protein S human has relations: drug_drug with Trabectedin, drug_drug with Trabectedin, drug_drug with Drotrecogin alfa, drug_drug w... | yes |
converted_572 | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB, phosphorylation of PLN, at either Ser(16) by PKA , Activation of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB), which relieves the inhibitory effects of PLB... | yes |
converted_356 | Is the yeast Μac1 transcription factor induced upon copper deficiency? | Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae., The copper-depletion induced CTR2 transcription can be abrogated by genetic deletion of copper-sensing transcription factor Mac1p, Taken together, our results suggest that Mac1p can activate the ... | yes |
converted_450 | Can SUMO affect calcium homeostasis? | Increasing SUMOylation levels correlated inversely with calcium influx in sensory neurons., CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant., Thus, our results identify a novel role for SUMO modification in CRMP2/CaV2.2 signaling pathway, Moreover, SUMO1 o... | yes |
converted_4291 | Is histone variant H3.3K27M associated with gliomas? | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling., Well-known oncohistones, with mutations on both H3.1 and H3.3, include H3K36M in chondroblastoma, H3K27M in glioma, Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children w... | yes |
converted_3531 | Is Huntington's disease is caused by expansion of a CTG repeat in the HTT gene on Chromosome 4? | Huntington's disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT)., Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion mutation in the huntingtin (HTT) gene, which results in the HTT protein that con... | no |
converted_271 | Is the Dictyostelium discoideum proteome known? | The Negative Proteome Database (NPD) is populated with pair-wise protein sequence comparisons between each of the following proteomes: Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Dictyostelium discoideum, Chlamydomonus reinhardti, Escherichia coli K12, Arabidop... | yes |
converted_3884 | Is there high nucleotide diversity in the Drosophila suzukii species? | Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here, we investigate the genetic population str... | yes |
converted_825 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | Two siblings died suddenly at the ages of 9 and 10 years, Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a type of cardiac arrhythmia that occurs in people with a structurally normal heart. Stress or anxiety-induced release of endogenous catecholamines causes a dysfunction in the myocytic calcium-ion c... | yes |
converted_1340 | Are there enhancer RNAs (eRNAs)? | active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription, eRNAs may then facilitate enhancer-promoter interaction or... | yes |
converted_1835 | Do statins cause diabetes? | Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients, The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing ... | yes |
converted_3012 | Is pimavanserin effective for Parkinson's disease psychosis? | Two cases of Parkinson's disease with an unusual delusional misidentification, intermetamorphosis, are presented, along with their improvement with pimavanserin, a novel atypical antipsychotic medication., RATIONALE: Pimavanserin, a selective serotonin 2A receptor inverse agonist, is a promising candidate for treating ... | yes |
converted_15 | Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer? | Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial., Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated cohorts. This implies... | yes |
converted_3880 | Does inactivation of CYLD help in colorectal cancer? | Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report., CYLD is a tumor suppressor that has been linked to the development of various human malignancies, including colon cancer. The tumor-suppressing function of CYLD is associated with its deubiqui... | no |
converted_4619 | Do we find bacteriophages in the gut? | a multitude of symbiotic bacteria and bacteriophages are decreased in abundance in patients with COVID-19, Bacterial viruses (bacteriophages, phages) of the gut have increasingly become a focus in microbiome studies, with an understanding that they are likely key players in health and disease., Already without exogenou... | yes |
converted_2372 | Is there any linear-time and linear-space algorithm for the computation of avoided words in biological sequences? | The systematic search for avoided words is particularly useful for biological sequence analysis. We present a linear-time and linear-space algorithm for the computation of avoided words of lengthkin a given sequencex. We suggest a modification to this algorithm so that it computes all avoided words ofx, irrespective of... | yes |
converted_1501 | Have germline variants been associated to colorectal cancer? | Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intron 10 ... | yes |
converted_3174 | Was stelara developed by Amgen? | NICE does not specifically recommend switching from one biologic to another, and only ustekinumab (UST; STELARA®, Janssen Pharmaceuticals, Inc., Horsham, PA, USA) is recommended after anti-tumour necrosis factor failure.[SEP]Relations: Ustekinumab has relations: drug_drug with AMG 108, drug_drug with AMG 108, drug_drug... | no |
converted_34 | Do mutations of AKT1 occur in meningiomas? | The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas., A mutation in PIK3CA or AKT1 was found in around 9 % of the cases., AKT1E17K mutations cluster with meningothelial an... | yes |
converted_2391 | Does the association of PARP1 and CTCF follow a circadian rhythm? | here we uncovered an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated domains (LADs)., Synchronization of the circadian rhythm by serum shock induces oscillations in PARP1-CTCF interactions, which is accompanied by oscillating recruitment of circadian loci to t... | yes |
converted_2092 | Can valproic acid prolong survival of glioblastoma patients? | For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment., This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment., Several in vivo and in vi... | yes |
converted_1475 | Is aganglionic megacolon a feature of Down syndrome? | Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS, Of the 17 patients with HD who w... | yes |
converted_4408 | Does UBE4B promote renal cancer? | UBE4B might act as an oncogene in regulating RCC development. Therefore it could be served as an effective indicator to predict OS and a potential biomarker for targeted therapy of RCC patients.[SEP]Relations: UBE4B has relations: anatomy_protein_present with kidney, anatomy_protein_present with kidney, protein_protein... | yes |
converted_1409 | Does Apolipoprotein E (ApoE) have anti-inflammatory activity? | have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternativ... | yes |
converted_345 | Are circRNAs associated with diseases and traits? | Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits., Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Their interaction with disease associated miRNAs indicates that circular RNAs are... | yes |
converted_704 | Are CD44 variants (CD44v) associated with poor prognosis of metastasis? | CD44 variants and prognosis, The CD44 variant (CD44v) isoforms have been noted as markers for tumour metastasis and prognosis in several adenocarcinomas., Positive CD44v3 expression was associated with more advanced pathological stage and poorer prognosis than negative CD44v3 expression, CD44v6 expression in the adenoc... | yes |
converted_431 | Is invasion and metastasis one of the hallmarks of cancer? | The pathogenesis of MM involves the accumulation of extensive cytogenetic changes, as well as cancer-related phenotypic alterations that facilitate tumor cell survival, invasion and metastasis. This review presents current knowledge regarding the biological characteristics of this disease that are linked to the so-call... | yes |
converted_3937 | Are mucins glycosylated proteins? | Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion., Mucin is a glycoprotein that is the primary component of the mucus overlaying the epithelial tissues. ... | yes |
converted_994 | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a chemical modification of DNA involved in the regulation of gene expression by controlling the access to the DNA sequence. , Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development., DNA methylation patter... | yes |
converted_1982 | Is lenvatinib effective for renal cell carcinoma? | However, the combination of lenvatinib, a multitargeted agent that inhibits VEGF as well as FGF receptors, and everolimus demonstrated promising results in a randomized phase II trial. , The FDA has approved the combination of lenvatinib and everolimus to treat advanced or metastatic renal cell carcinoma., Moreover, a ... | yes |
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