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PhdDz
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BioASQ_5_WITH_RELATION_vsimilarity_both_normalized

original_question stringlengths 20 192	id stringlengths 11 14	sentence1 stringlengths 24 217	sentence2 stringlengths 94 25.3k	label stringclasses 2 values
Can methylenetetrahydrofolate reductase (MTHFR) gene mutations cause homocystinuria?	converted_2090	Can methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) Gene Mutation cause Homocystinuria?	Methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) deficiency is a rare Autosomal Recessive Disorder. , Several mutations seen in methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) give rise to the formation of Hyperhomocysteinemia and Homocystinuria, a cons...	yes
Is Wnt16b secreted in response to chemotherapy?	converted_1129	Is Wnt16b secreted in response to chemotherapy?	In this study, we found WNT16B could be expressed and secreted into the microenvironment by Homo sapiens ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation., In a recent article in Nature Medicine, Sun et al. show that increased expression of Wnt family member wingles...	yes
There is no drug available to prevent HIV infection, Pre-exposure prophylaxis (PrEP), yes or no?	converted_2965	There is no drug available to prevent Human immunodeficiency virus II infection, Pre-exposure prophylaxis (HIV: PrEP and PEP), yes or no?	pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London - analysis of pharmacokinetics, safety and outcomes., The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (tenofovir dis...	no
Has the protein TIEG1 been associated with apoptosis?	converted_147	Has the protein TIEG1 been associated with apoptosis?	Recombinant Transforming Growth Factor-Beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in Recombinant Transforming Growth Factor-Beta sensitive pancreatic Tumor Cells, malignant, yet its effect on Recombinant Transforming Growth Factor-Beta resistant Tumor Cells, malignant remains unclear, overexpress...	yes
Have the promoter regions of the genes implicated in Rett Syndrome been characterized with CAGE?	converted_1899	Have the promoter regions of the genes implicated in MECP2 protein, Homo sapiens gene been characterized with CAGE?	CAGE-defined promoter regions of the genes implicated in MECP2 protein, Homo sapiens protein, Homo sapiens Genes., Gene Mutation in three functionally diverse genes cause MECP2 protein, Homo sapiens protein, Homo sapiens Genes. Although the functions of FOXG1 Genes (FOXG1), Methyl-CpG-Binding Protein 2 (MECP2 protein, ...	yes
Does smoking increase risk for glioblastoma?	converted_1125	Does Location characteristic ID - Smoking increase risk for glioblastoma?	Glioma risk has consistently been inversely associated with allergy history but not with Location characteristic ID - Smoking history despite putative biologic plausibility., No relation was observed between Glioma risk and Location characteristic ID - Smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P ...	no
Has istadefylline been considered as a treatment for Parkinson's disease?	converted_3602	Has istadefylline been considered as a treatment for Parkinson Disease?	istradefylline (Urethral intrinsic sphincter deficiency) is a new Pharmacologic Substance developed for the treatment of Parkinson Disease (Lugano Lymphoma Response Classification Progressive Disease by PET). It is an adenosine receptor A2A antagonists that will represent an important option for patients with advanced ...	yes
Should minocycline be used for mild Alzheimer disease?	converted_3984	Should minocycline be used for mild Alzheimer disease?	Conclusions and Relevance: minocycline did not delay the progress of cognitive or functional impairment in people with mild cytarabine/daunorubicin protocol during a 2-year period. [SEP]Relations: minocycline has relations: drug_effect with Arthritis, drug_effect with Arthritis, contraindication with kidney disease, co...	no
Are there clinical trials on stem cells in multiple sclerosis	converted_1057	Are there clinical trials on stem Cells in Multiple Sclerosis	Cells are generally given intravenously. Multiple sclerosis, Rheumatoid Arthritis and Discoid Discoid lupus erythematosus erythematosus have been successfully treated in Homo sapiens clinical trials, Human multipotent mesenchymal stem cell (selenomethylselenocysteine) therapies are currently being tested in clinical tr...	yes
Is amantadine effective for treatment of disorders conciousness?	converted_129	Is amantadine effective for treatment of disorders conciousness?	We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from Apraxia, oculomotor, Cogan type. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, lea...	yes
Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis?	converted_108	Are Stress Granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis?	Shprintzen-Goldberg syndrome have been linked to several pathologies including inflammatory diseases, Primary malignant neoplasm, Virus Diseases, and Neurodegenerative Disorders such as AMYOTROPHIC LATERAL SCLEROSIS 1 (ALS) and frontotemporal dementia (Frontotemporal dementia)., Like several other ALS-associated Protei...	yes
Is muscle lim protein (MLP) involved in cardiomyopathies?	converted_828	Is Muscle Tissue lim Protein Info (MARCKSL1 gene) involved in cardiomyopathies?	Muscle LIM Protein Info (MARCKSL1 gene) has been proposed to be a central player in the pathogenesis of Cardiomyopathies. In line with this notion, the homozygous loss of MARCKSL1 gene results in Cardiac - anatomy qualifier hypertrophy and Cardiomyopathy, Dilated. Moreover, MARCKSL1 gene is induced in several models of...	yes
Can multiple myeloma patients develop hyperviscosity syndrome?	converted_2451	Can Multiple Myeloma patients develop Hyperviscosity syndrome?	Multiple myeloma (millimeter) is an immedicable malignancy of the human plasma cells producing abnormal Antibodies, in vitro diagnostic (also referred to as Paraproteins) leading to kidney problems and Hyperviscosity syndrome. , This skin condition may be observed in patients with the following condtions, such as prima...	yes
Is Loss of function one of the cardinal signs of inflammation?	converted_2390	Is Loss of function one of the cardinal signs of Inflammation?	The concept of the four cardinal signs of acute Inflammation comes from antiquity as Redness et tumor cum calore et dolore, (Erythema and Swelling with heat and Pain:-:Point in time:^Patient:-) extended later by functio laesa (loss of function)., As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Cels...	yes
Does the Oncotype DX test work with paraffin embedded tissues?	converted_1713	Does the Oncotype DX Breast Cancer Assay test work with paraffin embedded tissues?	The Oncotype-DX Breast Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21 Genes in Malignant neoplasm of breast tissue by performing reverse transcription polymerase chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks that are obtained during initial surgery (...	yes
Does Yersinia pestis causes a respiratory infection?	converted_2040	Does Yersinia pestis causes a respiratory Communicable Diseases?	Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing Pneumonia, Yersinia pestis causes the fatal Respiratory Tract Diseases pneumonic plague., Pulmonary Communicable Diseases by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fat...	yes
Is there any research that relates the function of Notch Signaling with Alzheimer Disease?	converted_1491	Is there any research that relates the function of Notch Signaling with Alzheimer Disease?	RALBP1 gene regulates signaling pathways by abrogating or releasing signaling molecules. Since the discovery, already >15 years ago, of its catalytic component, Presenilin-1, and even much earlier with the identification of Amyloid beta-Protein Precursor as its first substrate, γ-secretase has been commonly associated ...	yes
Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish?	converted_1883	Is there any tool that facilitates the functional analysis of cis-regulatory regions in Zebrafish?	Zebrafish Enhancer of transcription detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in Zebrafish., he cis-regulatory sequences control when, where, and how much Genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. ...	yes
Does TRIM37 gene mutation causes Mulibrey nanism?	converted_1595	Does TRIM37 Protein Info, Homo sapiens gene Mutation Abnormality causes Mulibrey nanism?	OBJECTIVE: We studied pubertal development and fecundity in males with Mulibrey nanism (TRIM37 Protein Info, Homo sapiens wt Allele) caused by Gene Mutation in the TRIM37 Protein Info, Homo sapiens Protein Info, Homo sapiens gene., In TRIM37 Protein Info, Homo sapiens wt Allele, Gene Mutation in TRIM37 Protein Info, Ho...	yes
Is FKBP52 encoding a chaperone ?	converted_4296	Is tacrolimus binding protein 4 encoding a chaperone ?	HSP90AA1 wt Allele co-chaperones tissue-factor-pathway inhibitor 2 and FKBPs, The co-chaperone FK506-binding protein 51 (FKBP5 wt Allele), co‑chaperone tacrolimus binding protein 4 [SEP]Relations: tau protein binding has relations: molfunc_protein with FKBP4, molfunc_protein with FKBP4, molfunc_protein with PRKAA1, mol...	yes
Is subacute sclerosing panencephalitis caused by the Measles vaccine?	converted_2562	Is subacute sclerosing panencephalitis caused by the Measles vaccine?	Subacute Sclerosing Panencephalitis (SSPE) is a potentially fatal complication of measles. , Subacute Sclerosing Panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk f, Subacute Sclerosing Panencephalitis should be eliminated by measles vaccination, T...	no
Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer?	converted_15	Is the monoclonal immunoglobulin complex location trastuzumab (Herceptin) of potential use in the treatment of Malignant neoplasm of Pelvis>Prostate?	Herceptin is widely used in treating Her2-overexpressing Breast cancer. However, the application of Herceptin in Malignant neoplasm of Pelvis>Prostate is still controversial., Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated...	yes
Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans?	converted_2721	Is Brucella species abortus the organism that causes brucillosis known to cause spontaneous Abortions:Number:Point in time:^Patient:Quantitative:Reported in Homo sapiens?	. Brucellosis is a major cause of Fever of unknown origin (Pyrexia of unknown origin (excl puerperal)), Brucellosis is the most common Bacterial Zoonoses, and causes a considerable burden of Disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to Communicable Diseases with Brucell...	no
Is Rucaparib effective for ovarian cancer?	converted_2602	Is rucaparib effective for ovarian cancer?	INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and Loss of Heterozygosity high Platinum-Sensitive Disease ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type Loss of Heterozygosity low carcinomas., High Loss of Heterozygosity is associated...	yes
Does a tonsillectomy affect the patient's voice?	converted_2286	Does a tonsillectomy affect the patient's TelecommunicationCapabilities <voice>?	Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), TelecommunicationCapabilities <TelecommunicationCapabilities <voice>> change (61 vs 19%, P = .005), and Burn injury to Lip structure and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of t...	yes
Has ZP-PTH been tested in a phase II clinical trial?	converted_3387	Has ZP-PTH been tested in a phase II clinical trial?	This system was successfully tested in a Phase 2 clinical trial for the treatment of post-menopausal women with Encounter due to family history of Encounter due to family history of osteoporosis.[SEP]Relations: stenosis or atrophy of the coronary ostium has relations: disease_disease with abnormal origin or aberrant co...	yes
Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome?	converted_1105	Are Thyroid Hormones receptor alpha1 mutations implicated in Thyroid Hormones resistance syndrome?	Gene Mutation in Homo sapiens TRα1 mediate RTH with features of Hypothyroidism in particular Body tissue (e.g. skeleton, Multisection:Find:Pt:Abdomen+Pelvis>Gastrointestinal tract:Doc:US), but are not associated with a markedly dysregulated pituitary-thyroid axis., Clinical phenotype of a new type of Thyroid Hormones r...	yes
Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity?	converted_1274	Is Fanconi Genus Anemia presented as a genetically and clinically heterogeneous Disease entity?	Fanconi Anemia (doxorubicin/fluorouracil protocol) is a rare, Autosomal recessive inheritance, genetically complex, DNA repair deficiency syndrome in man. Patients with doxorubicin/fluorouracil protocol exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics...	yes
Is pazopanib an effective treatment of glioblastoma?	converted_2868	Is pazopanib an effective treatment of glioblastoma?	RESULTS: The six-month progression-free survival (PFS) rates in phase II (n = 41) were 0% and 15% in the PTEN/EGFRvIII-positive and PTEN/EGFRvIII-negative cohorts, respectively, leading to early termination. , Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity a...	no
Are long non coding RNAs as conserved in sequence as protein coding genes?	converted_63	Are long non coding RNAs as conserved in sequence as protein coding genes?	Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally., hey are under stronger selective pressure than neutrally evolving sequences-particularly in their Promoter Regions, Genetic, which display levels of selec...	no
Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia?	converted_1223	Is there any association of the chromosomal region harboring the gene ITIH3 gene with SCHIZOPHRENIA 2 (disorder)?	The most widely shared subset of genes-common to five of six disorders-included ANK3 gene gene, AS3MT gene gene, CACNA1C gene gene, CACNB2 gene gene, CNNM2 gene gene, CSMD1 protein, human protein, human, MUCL3 gene, ITIH3 gene gene, NT5C2 gene gene, PPP1R11 gene gene, SYNE1 gene gene, TCF7L2 protein, human, TENM4 gene ...	yes
Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate?	converted_3670	Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate?	TET proteins regulate the lineage specification and transcription-coupled nucleotide-excision repair-mediated expansion of Invariant Natural Killer T-Cells., We found that simultaneous Gene Deletion Abnormality of Probable Methylcytosine Dioxygenase TET2 and Methylcytosine Dioxygenase TET3 in Mus sp. CD4+CD8+ double-po...	yes
Does replication timing affect the rate of somatic mutations?	converted_888	Does replication timing affect the rate of somatic Gene Mutation?	Here we observe that Mutation Abnormality rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human Genome - anatomical entity, ll classes of substitutions are affected, suggesting a generalized mechanism involving replication ti...	yes
Is g-H2AX a marker for double strand breaks?	converted_3610	Is g-H2AX a marker for double strand breaks?	The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). , expression of the DNA double-strand break marker gamma-H2AX (γH2AX) , pH2AX, a marker of the DNA double-strand break (DSB)[SEP]Relations: Serine has relation...	yes
Is intraoperative radiotherapy used for treatment of glioblastoma?	converted_2166	Is intraoperative radiotherapy used for treatment of glioblastoma?	1) Intraoperative radiotherapy ( indolepyruvate ferredoxin oxidoreductase activity , 1,000-2,000 rad) was applied in 13 cases; the 2-year survival was 41.6%. , The median survival time after IORT was 12 months for 9 patients with glioblastoma or Anaplastic astrocytoma, while it was 51 months for 8 patients with less i...	no
Can sorafenib activate AMPK?	converted_328	Can sorafenib activate AMP-Activated Protein Kinases?	Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMP-Activated Protein Kinases), in a manner that involves either upstream LKB1 or CAMKK2 gene gene. , Persistent activation of AMP-Activated Protein Kinases by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKB...	yes
Are there interactomes available for POU5F1 and SOX2?	converted_1226	Are there interactomes available for POU5F1 protein, human and SOX2 protein, human?	The interactomes of POU5F1 protein, human protein, human and SOX2 protein, human protein, human enhancers in human embryonic stem cells., We assayed long-range chromosomal interactions on putative enhancers of POU5F1 protein, human protein, human and SOX2 protein, human protein, human Genes in human embryonic stem cell...	yes
Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia?	converted_364	Is alemtuzumab effective for remission induction in patients diagnosed with T-Cell Prolymphocytic Leukemia?	Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-Cell Prolymphocytic Leukemia, A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curre...	yes
Tocilizumab is an anti-TNF antibody, yes or no?	converted_3168	tocilizumab is an anti-Recombinant Tumor Necrosis Factor Family Protein antibody, yes or no?	was treated with tocilizumab, an anti-Interleukin 6 Receptor Monoclonal Antibody [EPC] , tocilizumab (TCZ) is a humanized Monoclonal Antibody [EPC] against Recombinant Interleukin-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult Rheumatoid Arthritis populations. Rheumatoid Arthritis ...	no
Does atemoya juice inhibit the CYP1A2 enzyme?	converted_4587	Does atemoya juice inhibit the CYP1A2 enzyme?	Atemoya juice significantly inhibited CYP1A2 activity in Homo sapiens liver microsomes, but not the activities of Cytochrome p450 Cytochrome p450 CYP2C9 enzyme enzyme and cytochrome P450 3A., This suggests that the intake of an excess amount of atemoya juice is necessary to cause a change in the pharmacokinetics of phe...	yes