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converted_4499 | Does Amblyopia affect the eye? | The main goal of our study is to assess the effect of transcranial magnetic stimulation, specifically theta burst stimulation (TBS), in a group of amblyopic volunteers measuring several visual parameters: visual acuity, suppressive imbalance, and stereoacuity, This study was undertaken to determine if optometrists in G... | yes |
converted_543 | Is the gene DUX4 epigenetically regulated in somatic cells? | There are several genes on chromosome 4q35 region including DUX4 within D4Z4 repeats. Transcription of these genes is usually repressed by epigenetic modifications of this chromosomal region and also accumulation of transcriptional repressors to the repeat array., Recent studies provide compelling evidence that a retro... | yes |
converted_406 | Can botulism poisoning of a pregnant woman harm her fetus? | Two botulism outbreaks were attributed to commercial ready-to-eat meat products and 3 to foods served in restaurants; several cases were attributed to non-Native home-prepared foods. Three affected pregnant women delivered healthy infants., Botulinum toxin is not expected to be present in systemic circulation following... | no |
converted_1948 | Do IEG create a ripple effect of transcription? | Rapid induction of immediate-early genes (IEGs) in response to growth factor stimulations is accompanied by co-upregulation of their neighbouring genes., Even in surrounding intergenic regions, transcriptional activation took place at the same time. , Here we show that intensive transcription at one locus frequently sp... | yes |
converted_3744 | Has tocilizumab been assessed against Covid-19? | Preliminary clinical results have indicated that antagonism of the IL-6 receptor (IL-6R), including with the FDA-approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID-19 while maintaining a good safety profile.[SEP]Relations: interleukin-6 receptor activi... | yes |
converted_2370 | Can the yeast protein Abf1 act as insulator? | Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a potent insulating capacity, Insulating domains in Rap1p coincide with previously described transcription activation domains, whereas four adjacent subdomains spanning the whole of the Abf1p C terminus (440-731) were found to display autonomous insulat... | yes |
converted_1411 | Is the ACE inhibitor indicated for lung cancer treatment? | The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease the risk of some cancers, although available data are conflicting. , Using cell viability and fluorescent activated cell sorting analysis tests, we demonstrated that captopril inhi... | no |
converted_2936 | Can midostaurin inhibit angiogenesis? | Midostaurin was a prototype kinase inhibitor, originally developed as a protein kinase C inhibitor and subsequently as an angiogenesis inhibitor, based on its inhibition of vascular endothelial growth factor receptor.[SEP]Relations: Midostaurin has relations: drug_drug with Estradiol, drug_drug with Estradiol, drug_dru... | yes |
converted_1723 | Does fibronectin constitute a serum biomarker for Duchenne muscular dystrophy? | Fibronectin is a serum biomarker for Duchenne muscular dystrophy, There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive ... | yes |
converted_688 | Is Ctf4 involved in sister chromatid cohesion establishment? | In addition to Eco1, several other factors contribute to cohesion establishment, including Ctf4, Ctf18, Tof1, Csm3, Chl1 and Mrc1, but little is known about their roles. Here, we show that each of these factors facilitates cohesin acetylation. Moreover, the absence of Ctf4 and Chl1, but not of the other factors, causes... | yes |
converted_4634 | Is HDAC1 required for GATA-1 transcriptional activity? | HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis., GATA-12RA knock-in (KI) mice suffer mild anemia and thrombocytopenia with accumulation of immature erythrocytes and megakaryocytes in bone marrow and spleen. Single cell RNA-seq analysis of Lin- cKit+ (LK) cells further ... | yes |
converted_3440 | Does teplizumab hold promise for diabetes prevention? | Anti-CD3 teplizumab and anti-CD3 otelixizumab have been shown to provide C-peptide preservation. , Underway are secondary prevention studies with teplizumab and with abatacept., INTERPRETATION: Findings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have incr... | yes |
converted_3710 | Has ORMD-0801 been tested in patients? | Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study., In efforts to provide patients with a more compliable treatment method, Oramed Pharmaceuticals tested the capacity of its oral insulin capsule (ORMD-0801, 8 mg insulin) in addressing this res... | yes |
converted_3875 | Is MK-1602 a CGRP antagonist? | The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine., This trial supports ubrogepant's efficacy and provides further evidence that CGRP-RAs are viable options for the acute treat... | yes |
converted_2451 | Can multiple myeloma patients develop hyperviscosity syndrome? | Multiple myeloma (MM) is an immedicable malignancy of the human plasma cells producing abnormal antibodies (also referred to as paraproteins) leading to kidney problems and hyperviscosity syndrome. , This skin condition may be observed in patients with the following condtions, such as primary polycythemic hyperviscosit... | yes |
converted_1478 | Is Titin the largest single protein molecule found in Nature? | Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly., Titin is the largest protein in mammals; it forms an elastic filament along the myofibril of cardiac and skeletal muscles., Titin is recently known as the largest protein... | yes |
converted_480 | Are epigenetic modifications implicated in cardiovascular development and disease? | Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored., The study of epigenetic markers is, therefore, a very promising frontier of scienc... | yes |
converted_2207 | Is Prochlorococcus the most abundant photosynthetic organism? | The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth., The marine cyanobacterium Prochlorococcus is the numerically dominant photosynthetic organism in the oligotrophic oceans, and a model system in marine microbial ecology., The marine cyanobacterium Prochlorococ... | yes |
converted_128 | Is MammaPrint cleared by the United States Food and Drug Administration? | Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel.[SEP]Relations: salivary gland type cancer of the breast has relations: disease_disease with breast cancer, disease_disease with br... | yes |
converted_317 | Have mutations in the Polycomb group been found in human diseases? | We identify a novel mutation in PHC1, a human orthologue of the Drosophila polyhomeotic member of polycomb group (PcG), which significantly decreases PHC1 protein expression, increases Geminin protein level and markedly abolishes the capacity to ubiquitinate histone H2A in patient cells., In clinical specimens of head ... | yes |
converted_2184 | Is hydroxyurea usually used to treated infectious disease? | Hydroxyurea represents the only available disease-modifying therapy for SCA, and has proven safety and efficacy in high-resource countries, In conclusion, the data here presented suggests that hydroxyurea may prevent priapism attacks in sickle cell disease, probably at higher doses than usually prescribed for painful c... | no |
converted_3046 | Does Rhamnose have any effect on aging? | The monosaccharide analysis showed that rhamnose (Rha) and glucose (Glu) may play vital roles in maintaining the antioxidant and anti-aging activities. , Some of these mechanisms will be reviewed as well as the capacity of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP) to counteract several of the... | yes |
converted_3370 | Is Nivolumab (Opdivo) a PD-L1 inhibitor? | Fatal Myocarditis Following Treatment with the PD-1 Inhibitor Nivolumab, PD-1 inhibitor nivolumab (Opdivo), programmed cell death protein 1 (PD-1)-blocking antibodies nivolumab or pembrolizumab , An improvement in the understanding of the role of the immune system in tumor immunosurveillance has led to the development... | no |
converted_2663 | Is the petrous bone used in ancient DNA sampling? | Large-scale genomic analyses of ancient human populations have become feasible partly due to refined sampling methods. The inner part of petrous bones and the cementum layer in teeth roots are currently recognized as the best substrates for such research., Ancient DNA (aDNA) research involves invasive and destructive s... | yes |
converted_2111 | Does the TOP2B/TOP2A expression ratio affect the response to AML chemotherapy? | High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia, Genes with distinct expression profiles such as TOP2B/TOP2A expression ratio at diagnosis can be employed for outcome prediction after the treatment with standard regimens in AML patie... | yes |
converted_3643 | Is Selumetinib effective for low-grade glioma? | Conclusion: Selumetinib has promising antitumor activity in children with LGG., INTERPRETATION
Selumetinib is active in recurrent, refractory, or progressive pilocytic astrocytoma harbouring common BRAF aberrations and NF1-associated paediatric low-grade glioma., These results show that selumetinib could be an alterna... | yes |
converted_1369 | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
converted_3465 | Are lamina-associated domains (LADs) associated with transcriptional activation? | Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains., Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes., Such lamina-associated dom... | no |
converted_2542 | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | The addition of poly(A) tails to eukaryotic nuclear mRNAs promotes their stability, export to the cytoplasm and translation. , Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3' ends, Polyadenylation is the non-template addition of adenosine nucleotides at the 3'-end of RNA, which oc... | no |
converted_3947 | Is there a link between rare variants in PPARG and type 1 diabetes? | Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes., By sequencing PPARG in 19,752 T2D cases and controls drawn from multiple studies and ethnic groups, we identified 49 previously unidentified, nonsynonymous PPARG variants (MAF < 0.5%). Con... | no |
converted_533 | Can a peptide aptamer be used as protein inhibitor? | Peptide aptamers of LIM-only protein 2 (Lmo2) were previously used to successfully treat Lmo2-induced tumours in a mouse model of leukaemia., Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity., Accumulating work over the past decade has shown t... | yes |
converted_3070 | Are recessive coding variants responsible for the majority of undiagnosed nonconsanguineous individuals? | Our results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.[SEP] | no |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_2657 | Are AAV vectors considered for the treatment of retinal dystrophies? | These novel gene vectors aim to more safely and efficiently transduce retinal cells, expand the gene packaging capacity of AAV, and utilize new strategies to correct the varying mechanisms of dysfunction found with inherited retinal dystrophies. [SEP]Relations: retinal dystrophy in systemic or cerebroretinal lipidoses... | yes |
converted_1574 | Does the concentration of protein HIF-1α increase after the administration of the cytoprotective prodrug"amifostine" (ethyol) ? | We demonstrated that the treatment of several human cancer cell lines with therapeutical doses of WR-1065 led to a strong induction of different VEGF-A mRNA isoforms independently of HIF-1alpha, e investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anh... | yes |
converted_2669 | Is CXCL7 a chemokine? | CXCL7, a chemokine highly expressed in platelets, , Chemokine CXCL7 Heterodimers[SEP]Relations: Chemokine receptors bind chemokines has relations: pathway_protein with CXCL8, pathway_protein with CXCL8, pathway_protein with CXCL5, pathway_protein with CXCL5, pathway_protein with CXCL6, pathway_protein with CXCL6, pathw... | yes |
converted_2592 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively., The bulk of these differ... | yes |
converted_2866 | Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | Randomized controlled trials have shown that simvastatin and intravenous magnesium do not prevent DCI or improve functional outcomes after aneurysmal subarachnoid hemorrhage (aSAH)., Conclusions Simvastatin showed no benefits in decreasing the incidence of vasospasm, DCI, or all-cause mortality after aneurysmal SAH. We... | no |
converted_4138 | Is methotrexate used for the treatment of Rheumatoid Arthritis (RA)? | The use of methotrexate in rheumatoid arthritis., Historical perspective on the use of methotrexate for the treatment of rheumatoid arthritis., Aminopterin, a folic acid analogue was first reported in 1948 to produce temporary remission of acute leukemia of children, was also reported in 1951 to produce an important an... | yes |
converted_1519 | Does nifedipine inhibit L-type calcium channels? | Nifedipine, an L-type calcium channel blocker, reduced the expression of synaptogamin and syntaxin and blocked the suppressive effect of vecuronium, suggesting that both agents inhibit presynaptic L-type calcium channels., Treatment with nifedipine to inhibit calcium influx via the L-type channel Cav1.2 (alpha(1C)) inh... | yes |
converted_1599 | Is there any protein that undergoes both mono-ubiquitination and poly-ubiquitination? | The yeast G protein alpha subunit Gpa1 represents a rare example of a protein that undergoes both mono- and poly-ubiquitination. , Expression of p34 promotes PTEN poly-ubiquitination, leading to PTEN protein degradation, whereas p34 knockdown results in PTEN mono-ubiquitination., These fingers possess E3 activities of ... | yes |
converted_4152 | Are there sex differences in oncogenic mutational processes? | Sex differences in oncogenic mutational processes.[SEP] | yes |
converted_4184 | Are interferons defensive proteins? | In response to viral infections, various pattern recognition receptors (PRRs) are activated for the production of type I interferon (IFN I). , activating interferon (IFN) production and positively regulating antiviral response in mammals. , The innate immune system, in particular the type I interferon (IFN) response, ... | yes |
converted_1037 | Is Vitamin D deficiency in pregnant women associated with gestational diabetes? | Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89, Vitamin D insufficiency is associated with an increased risk of gestational diabetes, p, Therefore, it is important to identify potentially modifiable risk factors for GDM. Accumu... | yes |
converted_2626 | Can nanoparticles be used for afterglow imaging? | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging, Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rar... | yes |
converted_182 | Does thyroid hormone regulate calcium transient in the myocardium? | 3-iodothyronamine (T(1)AM) is a novel endogenous relative of thyroid hormone, able to interact with trace amine-associated receptors, a class of plasma membrane G protein-coupled receptors, and to produce a negative inotropic and chronotropic effect, In adult rat cardiomyocytes acute exposure to 20 microM T(1)AM decrea... | yes |
converted_443 | Can we detect DNA strand asymmetries using dinucleotide relative abundance "genomic signatures"? | comparing the heterogeneities of bacterial genomes with respect to strand-independent first- and second-order features, (i) G + C content and (ii) dinucleotide relative abundance,, the concept of a genomic signature was introduced with the observation of species-type specific Dinucleotide Relative Abundance Profiles (D... | no |
converted_4694 | Are there any R packages that help with visualizing data on spirals? | spiralize: an R package for Visualizing Data on Spirals., Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here we present t... | yes |
converted_865 | Have C12orf65 mutations been associated with axonal neuropathy and optic atrophy? | Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy, Charcot-Marie Tooth disease (CMT) forms a clinically and genetically heterogeneous group of disorders. Although a number of disease genes have been identified for CMT, the gene discovery for some complex form of CMT has lagged behind. The as... | yes |
converted_3714 | Is deletion at 6q24.2-26 associated with shorter survival for ovarian cancer patients? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., Standard treatments for advanced high-grade serous ovarian carcinomas (HGSOCs) show significant side-effects and provide only short-term survival benefits due to disease recurrence. Thus, identification of novel pro... | no |
converted_347 | Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Z ∼ 1/X in genomes. The most powerful test is a new non-parametric one based upon the correlation ratio, which is able to reject Z ∼ 1/X in nine... | yes |
converted_552 | Is zyxin a focal adhesion protein? | zyxin from FAs, zyxin relocation from focal adhesions , . Here we systematically examined the expression, localization, and function of zyxin, a focal adhesion protein, focal adhesion protein zyxin, Focal adhesions formed in the absence of α-actinins are delayed in their maturation, exhibit altered morphology, have de... | yes |
converted_818 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury., Treatment with T3 (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. , Western blot analysis reve... | yes |
converted_2802 | Does gepotidacin activate bacterial topoisomerase? | GSK2140944 is a novel bacterial topoisomerase inhibitor in development for the treatment of bacterial infections.[SEP]Relations: Recurrent bacterial infections has relations: disease_phenotype_positive with purine nucleoside phosphorylase deficiency, disease_phenotype_positive with purine nucleoside phosphorylase defic... | no |
converted_2004 | Are there methods for generating highly multiplexed ChIP-seq libraries? | A method for generating highly multiplexed ChIP-seq libraries., The barcoding of next generation sequencing libraries has become an essential part of the experimental design. Barcoding not only allows the sequencing of more than one sample per lane, but also reduces technical bias. However, current barcoding strategies... | yes |
converted_79 | Are there any urine biomarkers for chronic kidney disease? | Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict CKD progression early in diabetic nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures., Both blood and urine biomarkers are reviewed in this paper and offer a consid... | yes |
converted_3074 | Has strimvelis been approved by the European Medicines Agency? | Strimvelis (autologous CD34+ cells transduced to express adenosine deaminase [ADA]) is the first ex vivo stem cell gene therapy approved by the European Medicines Agency (EMA), indicated as a single treatment for patients with ADA-severe combined immunodeficiency (ADA-SCID) who lack a suitable matched related bone marr... | yes |
converted_4279 | Are variants in FHF2 (also known as FGF13) associated with encephalopathy? | Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy., Whole-exome sequencing identified hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A). The X-linked FHF2 gene (also known as FGF13) has alternati... | yes |
converted_253 | Can life style changes reduce oxidative stress | The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated ... | yes |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_3501 | Do MAIT cells have a role in multiple myeloma? | hus, MAIT cells are reduced in MM patients, which may contribute to disease in these individuals, and moreover, MAIT cells may represent new immunotherapeutic targets for treatment of MM and other malignancies., Here we have analysed the frequency and function of MAIT cells in multiple myeloma (MM) patients. We show th... | yes |
converted_3379 | Is NicVAX vaccine effective for smoking cessation? | CONCLUSION: The nicotine vaccine, NicVAX, does not appear to improve the chances of stopping smoking when given in addition to varenicline and behavioural support., First efficacy results of the nicotine vaccine 3'-AmNic-rEPA (NicVAX) showed that only a subgroup of the top 30% antibody responders achieved higher absti... | no |
converted_4226 | Is phosphoenolpyruvate carboxykinase 1 (PCK1) the rate-limiting enzyme in gluconeogenesis? | Phosphoenolpyruvate carboxykinase (PEPCK) is a metabolic enzyme in the gluconeogenesis pathway,, PEPCK, a key enzyme involved in gluconeogenesis associated with a decrease in the expression of master genes involved in the VLDL synthesis , Transcriptome analysis of rate-limiting enzymes involved in hepatic gluconeogenes... | yes |
converted_1513 | Is thrombophilia related to increased risk of miscarriage? | Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH, for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetrical outcom... | yes |
converted_4119 | Can propofol cause green urine? | Reasons for discontinuing propofol are signs of rhabdomyolysis (92.9%), green urine, elevated liver enzymes (71.4% each) and elevated triglycerides (57.1%)., Propofol-Induced Green Urine in a Patient with Refractory Status Epilepticus., We present the case of a 52-year-old man, who developed green urine following propo... | yes |
converted_785 | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder., Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.... | yes |
converted_4038 | Is the process of DNA loop-extrusion independent of ATP? | The DNA-organizing mechanism of condensin depends on the energy of ATP hydrolysis but how this activity specifically promotes proper compaction and segregation of chromosomes during mitosis remains poorly understood., We suggest that loading and translocation are mediated by conformational changes in cohesin's hinge dr... | yes |
converted_2055 | Does Jarid2 play a role in early embryo development? | Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development, Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulat... | yes |
converted_3785 | Is yeast fbp1 affected by glucose starvation stress? | Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression, chromatin is reconstituted in the fission yeast Schizosaccharomyces pombefbp1 gene, which is robustly induced upon glucose starvation but tightly repressed under glucose-rich conditions., ... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_3222 | Is Pim-1 a protein phosphatase? | Pim-1 proto-oncogene, serine/threonine kinase (PIM-1) phosphorylates a series of substrates to exert its oncogenic function in numerous malignancies., The Pim1 serine/threonine kinase is associated with multiple cellular functions including proliferation, survival, differentiation, apoptosis, tumorigenesis, immune regu... | no |
converted_3884 | Is there high nucleotide diversity in the Drosophila suzukii species? | Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here, we investigate the genetic population str... | yes |
converted_1965 | Is butterfly rash a symptom of Systemic lupus erythematosus? | Diagnosing SLE can be challenging because of the myriad of clinical features and substantial variability between patients. Cutaneous involvement is present in about 60% of cases and typically manifests as a malar or butterfly rash., The prevalence of systemic lupus erythematosus (SLE) is 28 per 100,000. , We report a 1... | yes |
converted_1664 | Is the protein FAK (Focal Adhesion Kinase) phosphorylated? | Overexpression of NEDD9 led to tyrosine phosphorylation of FAK and SRC oncoproteins, , yrosine phosphorylated FAK, TNFα contributes for attenuating both Y397FAK and Y416Src phosphorylations in osteoblasts., It was possible to show that TNFα provokes attenuation at Y-phosphorylation of both FAK (at Y397 ), ownregulatio... | yes |
converted_3132 | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | Predicting Functions of Disordered Proteins with MoRFpred., Intrinsically disordered proteins and regions are involved in a wide range of cellular functions, and they often facilitate protein-protein interactions. Molecular recognition features (MoRFs) are segments of intrinsically disordered regions that bind to partn... | yes |
converted_2424 | Are organisms in the genus Morexella associated with sepsis? | Out of 130 culture proven cases of neonatal sepsis, gram negative bacteria were found in 71 (54.6%) cases and gram positive bacteria in 59 (45.4%) cases. Staphylococcus aureus was the most common bacteria found in 35 (26.9%) cases followed by Escherichia coli in 30 (23.1%) cases. Acinetobacter species, Staphylococcus e... | yes |
converted_1122 | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism., Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis, This is the first case of germline mosaicism in tuberous ... | yes |
converted_3169 | Is it possible to analyze exosomes with FACS? | whose presence was validated by a bead-exosome FACS assay., We analyzed exosomes from mouse (C57Bl/6) and breast, lung, and ovarian cancer patient samples and cultured cancer cells with different approaches, including nanoparticle tracking analysis, biolayer interferometry, FACS, and electron microscopy., we applied a ... | yes |
converted_511 | Is Alpers disease inherited in an autosomal recessive mode? | Alpers-Huttenlocher syndrome (AHS) is a very rare autosomal recessive disorder, Alpers syndrome is an autosomal recessive mitochondrial DNA depletion disorder that affects children and young adults, Alpers' syndrome is a fatal neurogenetic disorder first described more than 70 years ago. It is an autosomal recessive, d... | yes |
converted_1556 | Is CHEK2 involved in cell cycle control? | Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased., As CHEK2 is a cell-cycle master contro... | yes |
converted_419 | Are there transposon-free regions in mammalian genomes? | Transposon-free regions in mammalian genomes., Despite the presence of over 3 million transposons separated on average by approximately 500 bp, the human and mouse genomes each contain almost 1000 transposon-free regions (TFRs) over 10 kb in length. The majority of human TFRs correlate with orthologous TFRs in the mous... | yes |
converted_4311 | Does bleomycin cause lung toxicity? | bleomycin-induced pulmonary fibrosis, bleomycin (BLM)-induced pulmonary , Pulmonary toxicity is a devastating complication of bleomycin chemotherapy. , Bleomycin containing regimen is routinely employed in the treatment of HL. Pulmonary toxicity due to this drug is the most feared side effect in these regimens where th... | yes |
converted_1493 | Was modafinil tested for schizophrenia treatment? | Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study., CONCLUSION: The data suggest that modafinil was a safe adjunctive treatment which improved p... | yes |
converted_3243 | Does GRHL2 over-expression lead to EMT? | Grhl2 is down-regulated in disseminated cancer cells that have undergone EMT, and over-expression of Grhl2 is sufficient to induce epithelial gene expression., Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT and tumor progression., In breast cancer cell lines, shRNA-me... | no |
converted_1408 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | Here we refine our approach, and apply it to novel variants found in 2266 patients across two large cohorts with inherited sudden death syndromes, namely catecholaminergic polymorphic ventricular tachycardia (CPVT) or Brugada syndrome (BrS)., Calsequestrin-associated catecholaminergic polymorphic ventricular tachycardi... | yes |
converted_2478 | Is there an association between Klinefelter syndrome and breast cancer? | Screening for breast cancer in male-to-female transsexuals should be undertaken for those with additional risk factors (e.g., family history, BRCA2 mutation, Klinefelter syndrome) and should be available to those who desire screening, preferably in a clinical trial., Klinefelter syndrome (OR = 24.7; 95% CI = 8.94 to 68... | yes |
converted_3500 | Does deletion of cohesin change gene expression? | The conditional deletion of cohesin from noncycling thymocytes preserved enhancer position, H3K27ac, H4K4me1, and enhancer transcription, but weakened interactions between enhancers., Interestingly, ∼ 50% of deregulated genes reside in the vicinity of enhancer elements, suggesting that cohesin regulates gene expressio... | yes |
converted_3529 | Are CD8+ (cytotoxic) T cells and CD4+ Helper T cells generated in the thyroid and express the T-cell receptor? | A fundamental question in developmental immunology is how bipotential thymocyte precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages., CD4+CD8+ progenitor thymocytes undergo selection following interaction with MHC class I and class II molecules bearing peptide self-antigens, giving rise to CD8+ cyto... | no |
converted_2425 | Are there mammalian promoters with distal enhancer functions? | Genome-wide characterization of mammalian promoters with distal enhancer functions., Gene expression in mammals is precisely regulated by the combination of promoters and gene-distal regulatory regions, known as enhancers. Several studies have suggested that some promoters might have enhancer functions. However, the ex... | yes |
converted_4001 | Should nerinetide be used for treatment of ischaemic stroke? | 337 (61·4%) of 549 patients with nerinetide and 329 (59·2%) of 556 with placebo achieved an mRS score of 0-2 at 90 days (adjusted risk ratio 1·04, 95% CI 0·96-1·14; p=0·35). Secondary outcomes were similar between groups., INTERPRETATION: Nerinetide did not improve the proportion of patients achieving good clinical out... | no |
converted_1974 | Does mTOR regulate the translation of MAPKAPK2? | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype., Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show p... | yes |
converted_4418 | Do SETD1A mutations predispose to schizophrenia? | Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice., SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics... | yes |
converted_3444 | Does ProSavin use an adenoviral vector? | Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease., ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolerated in a Phase I/II first-in-human study, with significant improvements in... | no |
converted_2159 | Is autophagy the process where bacteria ingest viral particles? | Autophagy, a cellular degradation process, Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis., Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both ... | yes |
converted_3090 | Is eculizumab used for treatment of myasthenia gravis? | Eculizumab treatment improved symptoms compared with placebo in a phase II study in patients with refractory gMG. D, Eculizumab (Soliris) has been approved in several countries for refractory forms of generalized seropositive severe myasthenia gravis. , The humanized monoclonal antibody eculizumab (Soliris®) is a compl... | yes |
converted_1502 | Can Alzheimer's disease related miRNAs be detected in patients' blood? | miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD., miRN... | yes |
converted_509 | Is phospholamban a regulatory/inhibitory protein of the Ca ATPase SERCA? | The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) controls Ca(2+) transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism., Phospholamban (... | yes |
converted_1255 | Is lenvatinib effective for thyroid cancer? | New insights in the treatment of radioiodine refractory differentiated thyroid carcinomas: to lenvatinib and beyond., However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was con... | yes |
converted_1669 | Does ghrelin play a role in ischemic stroke? | Recent evidence suggests that ghrelin may also be neuroprotective after injury in animal models of cerebral ischemia., Overall, these experiments point to a neurodegenerative but antiapoptotic effect of endogenous ghrelin in this model of global ischemia, highlighting that further research is essential before we can ap... | yes |
converted_1414 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
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