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Mary, Mel and Sue all announced in September that they would stay with the BBC rather than move to Channel 4 with Bake Off and former colleague Paul.
UNITED NATIONS, December 23/24, updated -- As the UN Budget committee finally began voting at midnight, Iran's attempt to cut funding to the Group of Experts of its Sanctions Committee lost with 79 against, 36 abstaining and 11 for, including Venezuela, Ecuador, Zimbabwe, Swaziland and Myanmar.
Funding for the Durban III review day passed, 102 for, 33 abstaining and 17 against, including Canada and the United States, whose Joseph Melrose spoke.
Venezuela, Cuba and Nicaragua proposed a paragraph against Responsibility to Protect. Cuba spoke at length as did Nicaragua, denouncing the arrogance of R2P while speechifying to a GA hall full of half sleeping delegates.
Argentina's representative was sleeping, as was Swazilands. Russia had five large people, and took over a seat of Sierra Leone or the Seychelles.
Still, the ALBA group lost, 68 against, 51 abstaining and 17 for them in opposing R2P, including Qatar, the Solomon Island and not surprisingly Sudan. India voted “no,” that is, for R2P, a change from their prior Permanent Representative's position.
A vote was held on the overall Genocide resolution, now with only nine opposed including Iran, Ecuador and Zimbabwe. Iran called for a vote against all the Special Political Missions. On this, only Iran voted against, with three abstaining: North Korea, Myanmar and Syria - on Roed Larsen and Resolution 1559? Watch this site.
Updates: Budget committee meeting ends at 1:35 am with $5 billion quietly allocated.
At 1:44 am Eritrea takes the floor, quoting Henry Ford, a real Hallmark Card of a speech from a country dis-invited from the UN's September Somalia meeting.
At 2:23 am, after a coffee or drinks drink, full UNGA starts, with France complaining again about English only. Iceland rep has been knitting, Latvia sleeping. Deiss is not here. Why not?
As full UNGA votes on the budget, among countries absent is Somalia. Where's the TFG? Sri Lanka is here, but didn't vote on Iran resolutions. Very diplomatic.
In full UNGA, Durban III funding passes 104 for (2 more than in Budget committeee), 22 against (5 more) and 33 abstaining (same).
Fin: it's over, budget votes finished at 4:39 am, ritual Xmas tree up on voting screen, flashbulbs of cell phone cameras, handshakes, 10-4.
UNITED NATIONS, December 23 -- The UN Budget fight went into overtime Thursday evening on the issues of genocide and the Responsibility to Protect (R2P).
Venezuela, Cuba and Nicaragua put forward a proposal to bar the UN Special Representative on Genocide from having anything to do with R2P, which they say is a concept which has never been approved by the UN General Assembly and which could be used for imperialist interventions.
The standoff took place in the context of Cote d'Ivoire strongman Laurent Gbagbo issuing threats against the UN peacekeepers there.
Whereas Wednesday night UN officials Susana Malcorra, Catherine Pollard and Controller Yamasaki were on hand to lobby for the Secretariat, neither R2P Special Adviser Ed Luck nor current top genocide official Francis Deng were seen on Thursday evening.
No UNTV stake out had been set up for statements to the Press. Ban Ki-moon's spokespeople had left, and would not hold a briefing until 2011. Thus are billions fought for and spent.
Budget Committee diplomats milled around the UN's North Lawn building while negotiations continued in Conference Room 5. “OICT is done,” a delegate called out, referring to the Office of Information and Communications Technology. A final deadline was announced: 10 or 10:45 in the General Assembly.
There, contested votes were still predicted on Durban III and on Iran's challenge to the Group of Experts on its Sanctions Committee, and to Special Political Missions more generally.
Earlier the General Assembly met in its old building, but only to act on the Credentials Committee's recommendation to accept the new Cote d'Ivoire Mission personnel appointed by Ouattara. President of the General Assembly Joseph Deiss quickly read out the proposal and quickly gaveled approval.
Nigeria and Namibia protested that they had wanted to speak, even to ask for a postponement. But Deiss would not relent. With other countries asking to speak, Deiss suspended the meeting, to reconvene only when the Budget Committee is ready.
The decision promises to end a long-running shortage of medicines to treat one of the commonest emergencies in the poorest regions of Ghana – and one of the deadliest.
A tender for supplies of anti-snakebite serum was put out by the Ministry of Health and closed in August 2018. This was followed by just one round of full competitive bidding between six companies. Five then dropped out, some complaining about what they saw as special treatment for one company, which was allowed to review its tender document and offer.
The Ministry of Health then announced that the company ‒ Pharmanova Ltd, owned by the Indian businessman Dhananjay Tripathi ‒ had won the tender. Two rival firms raised objections, claiming that Pharmanova had underbid in the first round.
On 21 March, the PPA ordered the Ministry of Health to rescind its decision to offer the contract to Pharmanova and to put the tender out to the companies which lost in the first round.
The Daily Statesman understands that a member of the ministry’s procurement staff has been forced out following the PPA investigation.
A source close to one of the firms involved in the negotiations told the Daily Statesman: “During the bidding, Pharmanova offered the lowest price and was challenged by another company.
Pharmanova’s initial offer to supply its trademarked product, Vins, for GHC2,333,500 increased to GHC23 million ‒ against bids for products by two rival firms at GHC20 million and GHC20.75 million.
The rivals claimed it was clear after the first round of bidding that the Ministry of Health’s interest lay in one direction.
On 18 January the PPA announced it had launched an investigation into the tender after receiving two complaints. Within a week, the Ministry of Health backed down and said that it had cancelled the tender for anti-snakebite serum.
With last month’s decision, that is what the PPA has ordered the ministry to do. The serious doubts about cost were compounded by the Authority’s finding that Pharmanova in effect engaged in double bidding.
Two companies ‒ Pharmanova Export Private Ltd of India and Pharmanova Ltd of Ghana ‒ with the same owner, Mr Tripathi, bid in the first round. The Daily Statesman source described this as both unfair and borderline illegal.
The Daily Statesman’s source placed the blame for what he described as mismanagement of the tender squarely within the government department. “All mistakes lie at the door of the directorate of procurement at the Ministry of Health,” he said.
Pharmanova failed to respond to the Daily Statesman’s attempts to get it to put its side of the story. Senior officials at the ministry also declined several opportunities to comment.
The PPA’s decision promises to bring to an end accounts of a snakebite serum shortage in the North.
In December last year, the Daily Graphic reported that Wa Regional Hospital had run out of serum and at least three people had died in the previous two months for lack of access to the required medicine.
The acting medical director for the Wa hospital told the paper that it had in fact operated without the appropriate serum for the previous four months.
MENASHA - The Wildcats pulled off the upset road playoff win over Bay Conference foe Menasha.
Jefferson Cooper-Holmes is only a freshman but he made a veteran play at the buzzer, blocking a layup attempt by Alex Zeinert to preserve Green Bay West’s win.
The Bluejays, who had trailed by 10 points with 8:18 remaining, battled back to tie the game 49-49 on a 3-point basket by Jacob Everson with 25 seconds left.
Following a timeout by Green Bay West with 12 seconds left, Freeman Jackson found an opening down the lane for the go-ahead layup.
Jquail Hanks totaled 19 points to lead West in scoring, while Jackson added 17 points and Prince Robinson had seven points.
Benjamin Romnek recorded a game-high 20 points for Menasha, while Jacob Everson tallied 19 points and Zeinert scored eight points.
G.B. WEST- Jackson 17, Hanks 19, Dudley 2, Kirk 1, Coleman 2, Carter 3, Robinson 7. 3-pt: Jackson, Hanks 3. FT: 7-15. F: 12.
PESHTIGO – Peshtigo knocked out Clintonville in the first round to move on in the WIAA Tournament.
Trent Carriveau led the Bulldogs in scoring with 12 points while Max Neumann recorded a double double with 10 points and 10 rebounds.
For Clintonville, Kyle Finger tallied 11 points and Presley Rosenow and Aiden Polzin each finished with 10.
CLINTONVILLE – K. Finger 11, Rosenow 10, Polzin 10, S. Finger 4, Wittman 3, Morse 2, Viergutz 2. 3-pt: K. Finger 3, Rosenow 2, Polzin 2. FT: 4-8. F: 17.
PESHTIGO – Carriveau 12, Neumann 10, Noffke 9, VanVooren 6, Nielson 6, Marquardt 4, Sodini 4, Dionne 4, Tackmier 3. 3-pt: Tackmier 1. FT: 13-25. F: 13.
DENMARK – Zane Short led Denmark past Kiel in a first-round blowout.
Short finished with a game-high of 28 points, including four three-pointers. Brady Jens also contributed to the Vikings’ victory with 15 points and Patrick Suemnick chipped in 12.
KIEL – Klauck 11, Goebel 11, Voelker 7, Winkel 6, Rattatz 4, Lepisto 4, Cieslewicz 2, Kuhn 2, Dodering 1. 3-pt: Goebel 3, Winkel 1, Voelker 1. FT: 4-6. F: 18.
DENMARK – Short 28, Jens 15, Suemnick 12, Pelischek 10, Sipiorski 7, Rabas 6, Vakselis 4, Honnef 4, Satori 3. 3-pt: Short 4, Jens 3, Satori 1, Pelischek 1. FT: 18-23. F: 10.
APPLETON - The No. 9 seeded Panthers outscored the No. 8 seeded Foxes 31-20 in the first half and held on to get the win in a regional quarterfinal game.
Mitchell Manns led Oconto Falls with 15 points.
Stephen Baehman paced the Foxes with 20 points.
OCONTO FALLS - Sefcik 9, Nelson 14, Manns 15, Schoen 7, Carriveau 16, Parsons 4. 3-pt: Sefcik, Nelson 2, Manns 3, Carriveau. FT: 12-16. F: 14.
FOX VALLEY LUTHERAN - Thiesfeldt 3, Steigenberger 12, Ulman 4, Baehman 20, Jens 3, Behm 2, Blobe 3, Uitebroek 5. 3-pt: Thiesfeldt, Steigenberger, Ulman, Baehman 3, Jens. FT: 9-18. F: 17.
BONDUEL - Bryce Weier broke a school record for points in a game to lead Bonduel to a home playoff win.
Weier recorded a game-high 48 points to set a team record, including seven 3-pointers for the Bears.
Parker Bohm tallied 29 assists for Bonduel, while Dalton Cairns has 23 points and Cole Letter added 14 assists.
Warren Wilber led Menominee Indian with 29 points, while Richard Wayka totaled 20 points. Both Nathan Frechette and Raymond Fish scored 10 points for the Eagles.
MENOMINEE INDIAN – Wilber 29, Corn 3, Frechette 10, Wayka 20, Caldwell 4, Waukau 1, Lyons 9, Fish 10, Kakwitch 6. 3-pt: Wilber 3, Frechette 2, Lyons 1, Fish 1. FT: 17-28. F: 22.
BONDUEL – Weier 46, Garside 5, Letter 3, Bohm 29, Burch 23. 3-pt: Weier 7, Garside 1, Letter 1, Bohm 2. FT: 22-28. F: 17.
COLEMAN – After trailing by 15 points at halftime, Coleman made an astounding comeback in the second half to stay alive in the WIAA Tournament.
Austin Marquardt led the Cougars with 20 points, including five three-pointers. Meanwhile, Cole Woulf finished with 17 points and Cayden Bintz registered 13.
Jacob Christianson was Wabeno-Laona’s leading scorer with 13 points.
WABENO-LAONA – Christianson 13, Pakulski 11, Caley 11, Brauer 4, Jakubiec 4. 3-pt: Christianson 3, Caley 1. FT: 9-18. F: 13.
COLEMAN – Marquardt 20, Woulf 17, Bintz 13, Nelson 4, Fraser 2, Teteak 1. 3-pt: Marquardt 5, Bintz 3. FT: 7-13. F: 19.
SURING - The Eagles won the home playoff game in convincing fashion to advance to the next round.
Ryan Mahoney led all scorers with a game-high 28 points for Suring, while Caleb Lally had 16 points and Mitch Stegeman scored 11 points.
Mac Morrison tallied 15 points to lead Elcho in scoring.
ELCHO – Morrison 15, Novak 7, Klingler 5, Wheeler 4. 3-pt: Morrison 2, Novak 1, Klingler 1. FT: 3-5. F: 8.
SURING – Mahoney 28, Smith 6, Stegeman 11, Sepulveda 4, Lally 16, Hischke 2, Garrigan 4. 3-pt: Mahoney 4, Stegeman 1. FT: 6-8. F: 7.
ONEIDA – Oneida Nation defended their home court in the first round of the playoffs with a win against Valley Christian.
Ryan King led the Thunderhawks with 15 points while Seth Charles scored 13 and Richard Summers added 11.
For Valley Christian, Isaiah Wade scored a game-high of 12 points.
VALLEY CHRISTIAN – Wade 21, Jeffers 10, Dunn 9, McFarlane , Francis 2, Giannopoulos 2, Curtis 2. 3-pt: Dunn 3. FT: 5-16. F: 25.
ONEIDA NATION – King 15, Charles 13, Summers 11, Hill 6, Fowler 4, Jordan 3. 3-pt: Summers 2, King 1. FT: 11-20. F: 16.
GREEN BAY – NEW Lutheran survived in the first round in the first half after extending their lead to double digits in the second half.
Luke Bukowski finished with 13 points for the Blazers, including three three-pointers. Meanwhile, Jacob Champeau tallied 11 points in the victory.
For Sevastopol, Nelson Demmin led all scorers with 15 points, as well as five three-pointers.
SEVASTOPOL – Demmin 15, Pollman 9, Haberli 9, Pflieger 6, Garcia 5, Krohn 2, Rosales 2. 3-pt: Demmin 5, Pollman 2, Pflieger 1, Haberli 1, Garcia 1. FT: 6-8. F: 13.
NEW LUTHERAN– L. Bukowski 13, Champeau 11, M. Bukowski 9, Kinot 8, Meerstein 7, Reisler 5, Luepke 3, Gast 3, Bullock 2. 3-pt: L. Bukowski 3, Champewau 1, Luepke 1. FT: 12-21. F: 12.
WAUSAUKEE - The Rangers held on in the second-half to win and advance to the next round.
Matt Delfosse totaled a game-high 25 points for Wausaukee, while Hayden Renikow scored 13 points and Brandon Shigouri had 12 points.
For Niagara, Austin Hagerty led the way with 15 points. Alex Hagerty totaled 12 points for the Badgers and Tristan DeJardin added eight points.
NIAGARA – Oratch 2, Kaldor 2, Al. Hagerty 12, Au. Hagerty 15, Antonissen 2, DeJardin 8, Hansen 3, Prideaux 5. 3-pt: Au. Hagerty 1. FT: 14-31. F: 18.
WAUSAUKEE – Gruszynski 2, B. Shigouri 12, C. Shigouri 2, Schroeder 2, Renikow 13, Delfosse 25, Thomson 2. 3-pt: None. FT: 14-20. F: 20.
Neoadjuvant immunotherapy with the PD-1 inhibitor nivolumab is safe and feasible prior to surgery for early lung cancer, researchers reported at the ESMO 2016 Congress in Copenhagen.
"Until now nivolumab and the other anti-PD-1 and anti-PD-L1 drug studies have only been reported in metastatic or advanced lung cancer," said lead author Dr Patrick Forde, Assistant Professor of Oncology, Sidney Kimmel Comprehensive Cancer Centre, Johns Hopkins, Baltimore, US. "This was the first study of neoadjuvant PD-1 blockade in early stage lung cancer."
The primary objective of the study was to see whether it was safe and feasible to administer neoadjuvant nivolumab to patients with early stage non-small-cell lung cancer (NSCLC) prior to resection of the tumour. Treatment was considered feasible if it did not delay surgery.
Exploratory aims included extensive correlative analyses of the pretreatment biopsy and post-treatment resected tumour including PD-L1 staining, multiplex immunohistochemistry and T cell receptor sequencing. An additional exploratory analysis looked at the degree of pathological regression. This was analysed by a lung cancer pathologist using a method previously reported for use in measuring response to neoadjuvant chemotherapy in NSCLC. Major pathological regression (90% or more) was defined as a resected specimen with less than 10% remaining viable tumour cells.
The study included 20 patients who had a tumour biopsy taken. They then received two doses of nivolumab at four and two weeks prior to surgical resection of the tumour.
The results in the first 16 patients were presented today. The investigators found that there were no significant safety concerns and no delays to surgery with nivolumab.
Six of 15 patients (40%) had major pathological regression of their tumour following nivolumab. All of those tumours had dense infiltration of immune cells and either a complete pathologic response or isolated remaining tumour cells. An additional five patients had some regression of their tumour noted and evidence of immune infiltration. Multiplex IHC demonstrated infiltration of cytotoxic T cells into the tumours and also detection of new T cell clones in the tumour that did not appear to be present in the pre-treatment biopsy.
Forde said: "We found that neoadjuvant administration of nivolumab is safe and feasible in stage I-IIIA NSCLC and also a preliminary signal that anti-PD-1 immunotherapy may have activity in early stage lung cancer. Following these initial results we are expanding the study. One cohort will receive a third dose of nivolumab preoperatively and the other will receive the combination of nivolumab and ipilimumab preoperatively. This expanded study will continue to be conducted in collaboration with investigators at Johns Hopkins University and Memorial Sloan-Kettering Cancer Centre. Others, such as the Lung Cancer Mutation Consortium in the United States, are also conducting larger studies of neoadjuvant immune checkpoint inhibition in NSCLC."
Commenting on the study, Professor Pieter Postmus, chair of Thoracic Oncology at the University of Liverpool, UK, said: "There is a potential for bias when comparing a small biopsy, which might not represent the whole tumour, with the resected tumour. This is not a validated way to measure response to a treatment. It describes a biological effect but whether that has any clinical impact on survival is unproven."
"Although we do not know for the time being if a major pathological response is correlated with improved survival, this method could first be validated in a cohort of patients with advanced disease by comparing the percentages of viable tumour cells in tumour biopsies taken before and four to eight weeks after immunotherapy," continued Postmus. "If in this way regression - as defined in the preoperative study - correlates with survival in patients with advanced cancer, it is likely to hold true in less advanced or resectable patients. Long-term survival data will be the ultimate test for these neoadjuvant immunotherapy strategies."

Mary, Mel and Sue all announced in September that they would stay with the BBC rather than move to Channel 4 with Bake Off and former colleague Paul.

UNITED NATIONS, December 23/24, updated -- As the UN Budget committee finally began voting at midnight, Iran's attempt to cut funding to the Group of Experts of its Sanctions Committee lost with 79 against, 36 abstaining and 11 for, including Venezuela, Ecuador, Zimbabwe, Swaziland and Myanmar.

Funding for the Durban III review day passed, 102 for, 33 abstaining and 17 against, including Canada and the United States, whose Joseph Melrose spoke.

Venezuela, Cuba and Nicaragua proposed a paragraph against Responsibility to Protect. Cuba spoke at length as did Nicaragua, denouncing the arrogance of R2P while speechifying to a GA hall full of half sleeping delegates.

Argentina's representative was sleeping, as was Swazilands. Russia had five large people, and took over a seat of Sierra Leone or the Seychelles.

Still, the ALBA group lost, 68 against, 51 abstaining and 17 for them in opposing R2P, including Qatar, the Solomon Island and not surprisingly Sudan. India voted “no,” that is, for R2P, a change from their prior Permanent Representative's position.

A vote was held on the overall Genocide resolution, now with only nine opposed including Iran, Ecuador and Zimbabwe. Iran called for a vote against all the Special Political Missions. On this, only Iran voted against, with three abstaining: North Korea, Myanmar and Syria - on Roed Larsen and Resolution 1559? Watch this site.

Updates: Budget committee meeting ends at 1:35 am with $5 billion quietly allocated.

At 1:44 am Eritrea takes the floor, quoting Henry Ford, a real Hallmark Card of a speech from a country dis-invited from the UN's September Somalia meeting.

At 2:23 am, after a coffee or drinks drink, full UNGA starts, with France complaining again about English only. Iceland rep has been knitting, Latvia sleeping. Deiss is not here. Why not?

As full UNGA votes on the budget, among countries absent is Somalia. Where's the TFG? Sri Lanka is here, but didn't vote on Iran resolutions. Very diplomatic.

In full UNGA, Durban III funding passes 104 for (2 more than in Budget committeee), 22 against (5 more) and 33 abstaining (same).

Fin: it's over, budget votes finished at 4:39 am, ritual Xmas tree up on voting screen, flashbulbs of cell phone cameras, handshakes, 10-4.

UNITED NATIONS, December 23 -- The UN Budget fight went into overtime Thursday evening on the issues of genocide and the Responsibility to Protect (R2P).

Venezuela, Cuba and Nicaragua put forward a proposal to bar the UN Special Representative on Genocide from having anything to do with R2P, which they say is a concept which has never been approved by the UN General Assembly and which could be used for imperialist interventions.

The standoff took place in the context of Cote d'Ivoire strongman Laurent Gbagbo issuing threats against the UN peacekeepers there.

Whereas Wednesday night UN officials Susana Malcorra, Catherine Pollard and Controller Yamasaki were on hand to lobby for the Secretariat, neither R2P Special Adviser Ed Luck nor current top genocide official Francis Deng were seen on Thursday evening.

No UNTV stake out had been set up for statements to the Press. Ban Ki-moon's spokespeople had left, and would not hold a briefing until 2011. Thus are billions fought for and spent.

Budget Committee diplomats milled around the UN's North Lawn building while negotiations continued in Conference Room 5. “OICT is done,” a delegate called out, referring to the Office of Information and Communications Technology. A final deadline was announced: 10 or 10:45 in the General Assembly.

There, contested votes were still predicted on Durban III and on Iran's challenge to the Group of Experts on its Sanctions Committee, and to Special Political Missions more generally.

Earlier the General Assembly met in its old building, but only to act on the Credentials Committee's recommendation to accept the new Cote d'Ivoire Mission personnel appointed by Ouattara. President of the General Assembly Joseph Deiss quickly read out the proposal and quickly gaveled approval.

Nigeria and Namibia protested that they had wanted to speak, even to ask for a postponement. But Deiss would not relent. With other countries asking to speak, Deiss suspended the meeting, to reconvene only when the Budget Committee is ready.

The decision promises to end a long-running shortage of medicines to treat one of the commonest emergencies in the poorest regions of Ghana – and one of the deadliest.

A tender for supplies of anti-snakebite serum was put out by the Ministry of Health and closed in August 2018. This was followed by just one round of full competitive bidding between six companies. Five then dropped out, some complaining about what they saw as special treatment for one company, which was allowed to review its tender document and offer.

The Ministry of Health then announced that the company ‒ Pharmanova Ltd, owned by the Indian businessman Dhananjay Tripathi ‒ had won the tender. Two rival firms raised objections, claiming that Pharmanova had underbid in the first round.

On 21 March, the PPA ordered the Ministry of Health to rescind its decision to offer the contract to Pharmanova and to put the tender out to the companies which lost in the first round.

The Daily Statesman understands that a member of the ministry’s procurement staff has been forced out following the PPA investigation.

A source close to one of the firms involved in the negotiations told the Daily Statesman: “During the bidding, Pharmanova offered the lowest price and was challenged by another company.

Pharmanova’s initial offer to supply its trademarked product, Vins, for GHC2,333,500 increased to GHC23 million ‒ against bids for products by two rival firms at GHC20 million and GHC20.75 million.

The rivals claimed it was clear after the first round of bidding that the Ministry of Health’s interest lay in one direction.

On 18 January the PPA announced it had launched an investigation into the tender after receiving two complaints. Within a week, the Ministry of Health backed down and said that it had cancelled the tender for anti-snakebite serum.

With last month’s decision, that is what the PPA has ordered the ministry to do. The serious doubts about cost were compounded by the Authority’s finding that Pharmanova in effect engaged in double bidding.

Two companies ‒ Pharmanova Export Private Ltd of India and Pharmanova Ltd of Ghana ‒ with the same owner, Mr Tripathi, bid in the first round. The Daily Statesman source described this as both unfair and borderline illegal.

The Daily Statesman’s source placed the blame for what he described as mismanagement of the tender squarely within the government department. “All mistakes lie at the door of the directorate of procurement at the Ministry of Health,” he said.

Pharmanova failed to respond to the Daily Statesman’s attempts to get it to put its side of the story. Senior officials at the ministry also declined several opportunities to comment.

The PPA’s decision promises to bring to an end accounts of a snakebite serum shortage in the North.

In December last year, the Daily Graphic reported that Wa Regional Hospital had run out of serum and at least three people had died in the previous two months for lack of access to the required medicine.

The acting medical director for the Wa hospital told the paper that it had in fact operated without the appropriate serum for the previous four months.

MENASHA - The Wildcats pulled off the upset road playoff win over Bay Conference foe Menasha.

Jefferson Cooper-Holmes is only a freshman but he made a veteran play at the buzzer, blocking a layup attempt by Alex Zeinert to preserve Green Bay West’s win.

The Bluejays, who had trailed by 10 points with 8:18 remaining, battled back to tie the game 49-49 on a 3-point basket by Jacob Everson with 25 seconds left.

Following a timeout by Green Bay West with 12 seconds left, Freeman Jackson found an opening down the lane for the go-ahead layup.

Jquail Hanks totaled 19 points to lead West in scoring, while Jackson added 17 points and Prince Robinson had seven points.

Benjamin Romnek recorded a game-high 20 points for Menasha, while Jacob Everson tallied 19 points and Zeinert scored eight points.

G.B. WEST- Jackson 17, Hanks 19, Dudley 2, Kirk 1, Coleman 2, Carter 3, Robinson 7. 3-pt: Jackson, Hanks 3. FT: 7-15. F: 12.

PESHTIGO – Peshtigo knocked out Clintonville in the first round to move on in the WIAA Tournament.

Trent Carriveau led the Bulldogs in scoring with 12 points while Max Neumann recorded a double double with 10 points and 10 rebounds.

For Clintonville, Kyle Finger tallied 11 points and Presley Rosenow and Aiden Polzin each finished with 10.

CLINTONVILLE – K. Finger 11, Rosenow 10, Polzin 10, S. Finger 4, Wittman 3, Morse 2, Viergutz 2. 3-pt: K. Finger 3, Rosenow 2, Polzin 2. FT: 4-8. F: 17.

PESHTIGO – Carriveau 12, Neumann 10, Noffke 9, VanVooren 6, Nielson 6, Marquardt 4, Sodini 4, Dionne 4, Tackmier 3. 3-pt: Tackmier 1. FT: 13-25. F: 13.

DENMARK – Zane Short led Denmark past Kiel in a first-round blowout.

Short finished with a game-high of 28 points, including four three-pointers. Brady Jens also contributed to the Vikings’ victory with 15 points and Patrick Suemnick chipped in 12.

KIEL – Klauck 11, Goebel 11, Voelker 7, Winkel 6, Rattatz 4, Lepisto 4, Cieslewicz 2, Kuhn 2, Dodering 1. 3-pt: Goebel 3, Winkel 1, Voelker 1. FT: 4-6. F: 18.

DENMARK – Short 28, Jens 15, Suemnick 12, Pelischek 10, Sipiorski 7, Rabas 6, Vakselis 4, Honnef 4, Satori 3. 3-pt: Short 4, Jens 3, Satori 1, Pelischek 1. FT: 18-23. F: 10.

APPLETON - The No. 9 seeded Panthers outscored the No. 8 seeded Foxes 31-20 in the first half and held on to get the win in a regional quarterfinal game.

Mitchell Manns led Oconto Falls with 15 points.

Stephen Baehman paced the Foxes with 20 points.

OCONTO FALLS - Sefcik 9, Nelson 14, Manns 15, Schoen 7, Carriveau 16, Parsons 4. 3-pt: Sefcik, Nelson 2, Manns 3, Carriveau. FT: 12-16. F: 14.

FOX VALLEY LUTHERAN - Thiesfeldt 3, Steigenberger 12, Ulman 4, Baehman 20, Jens 3, Behm 2, Blobe 3, Uitebroek 5. 3-pt: Thiesfeldt, Steigenberger, Ulman, Baehman 3, Jens. FT: 9-18. F: 17.

BONDUEL - Bryce Weier broke a school record for points in a game to lead Bonduel to a home playoff win.

Weier recorded a game-high 48 points to set a team record, including seven 3-pointers for the Bears.

Parker Bohm tallied 29 assists for Bonduel, while Dalton Cairns has 23 points and Cole Letter added 14 assists.

Warren Wilber led Menominee Indian with 29 points, while Richard Wayka totaled 20 points. Both Nathan Frechette and Raymond Fish scored 10 points for the Eagles.

MENOMINEE INDIAN – Wilber 29, Corn 3, Frechette 10, Wayka 20, Caldwell 4, Waukau 1, Lyons 9, Fish 10, Kakwitch 6. 3-pt: Wilber 3, Frechette 2, Lyons 1, Fish 1. FT: 17-28. F: 22.

BONDUEL – Weier 46, Garside 5, Letter 3, Bohm 29, Burch 23. 3-pt: Weier 7, Garside 1, Letter 1, Bohm 2. FT: 22-28. F: 17.

COLEMAN – After trailing by 15 points at halftime, Coleman made an astounding comeback in the second half to stay alive in the WIAA Tournament.

Austin Marquardt led the Cougars with 20 points, including five three-pointers. Meanwhile, Cole Woulf finished with 17 points and Cayden Bintz registered 13.

Jacob Christianson was Wabeno-Laona’s leading scorer with 13 points.

WABENO-LAONA – Christianson 13, Pakulski 11, Caley 11, Brauer 4, Jakubiec 4. 3-pt: Christianson 3, Caley 1. FT: 9-18. F: 13.

COLEMAN – Marquardt 20, Woulf 17, Bintz 13, Nelson 4, Fraser 2, Teteak 1. 3-pt: Marquardt 5, Bintz 3. FT: 7-13. F: 19.

SURING - The Eagles won the home playoff game in convincing fashion to advance to the next round.

Ryan Mahoney led all scorers with a game-high 28 points for Suring, while Caleb Lally had 16 points and Mitch Stegeman scored 11 points.

Mac Morrison tallied 15 points to lead Elcho in scoring.

ELCHO – Morrison 15, Novak 7, Klingler 5, Wheeler 4. 3-pt: Morrison 2, Novak 1, Klingler 1. FT: 3-5. F: 8.

SURING – Mahoney 28, Smith 6, Stegeman 11, Sepulveda 4, Lally 16, Hischke 2, Garrigan 4. 3-pt: Mahoney 4, Stegeman 1. FT: 6-8. F: 7.

ONEIDA – Oneida Nation defended their home court in the first round of the playoffs with a win against Valley Christian.

Ryan King led the Thunderhawks with 15 points while Seth Charles scored 13 and Richard Summers added 11.

For Valley Christian, Isaiah Wade scored a game-high of 12 points.

VALLEY CHRISTIAN – Wade 21, Jeffers 10, Dunn 9, McFarlane , Francis 2, Giannopoulos 2, Curtis 2. 3-pt: Dunn 3. FT: 5-16. F: 25.

ONEIDA NATION – King 15, Charles 13, Summers 11, Hill 6, Fowler 4, Jordan 3. 3-pt: Summers 2, King 1. FT: 11-20. F: 16.

GREEN BAY – NEW Lutheran survived in the first round in the first half after extending their lead to double digits in the second half.

Luke Bukowski finished with 13 points for the Blazers, including three three-pointers. Meanwhile, Jacob Champeau tallied 11 points in the victory.

For Sevastopol, Nelson Demmin led all scorers with 15 points, as well as five three-pointers.

SEVASTOPOL – Demmin 15, Pollman 9, Haberli 9, Pflieger 6, Garcia 5, Krohn 2, Rosales 2. 3-pt: Demmin 5, Pollman 2, Pflieger 1, Haberli 1, Garcia 1. FT: 6-8. F: 13.

NEW LUTHERAN– L. Bukowski 13, Champeau 11, M. Bukowski 9, Kinot 8, Meerstein 7, Reisler 5, Luepke 3, Gast 3, Bullock 2. 3-pt: L. Bukowski 3, Champewau 1, Luepke 1. FT: 12-21. F: 12.

WAUSAUKEE - The Rangers held on in the second-half to win and advance to the next round.

Matt Delfosse totaled a game-high 25 points for Wausaukee, while Hayden Renikow scored 13 points and Brandon Shigouri had 12 points.

For Niagara, Austin Hagerty led the way with 15 points. Alex Hagerty totaled 12 points for the Badgers and Tristan DeJardin added eight points.

NIAGARA – Oratch 2, Kaldor 2, Al. Hagerty 12, Au. Hagerty 15, Antonissen 2, DeJardin 8, Hansen 3, Prideaux 5. 3-pt: Au. Hagerty 1. FT: 14-31. F: 18.

WAUSAUKEE – Gruszynski 2, B. Shigouri 12, C. Shigouri 2, Schroeder 2, Renikow 13, Delfosse 25, Thomson 2. 3-pt: None. FT: 14-20. F: 20.

Neoadjuvant immunotherapy with the PD-1 inhibitor nivolumab is safe and feasible prior to surgery for early lung cancer, researchers reported at the ESMO 2016 Congress in Copenhagen.

"Until now nivolumab and the other anti-PD-1 and anti-PD-L1 drug studies have only been reported in metastatic or advanced lung cancer," said lead author Dr Patrick Forde, Assistant Professor of Oncology, Sidney Kimmel Comprehensive Cancer Centre, Johns Hopkins, Baltimore, US. "This was the first study of neoadjuvant PD-1 blockade in early stage lung cancer."

The primary objective of the study was to see whether it was safe and feasible to administer neoadjuvant nivolumab to patients with early stage non-small-cell lung cancer (NSCLC) prior to resection of the tumour. Treatment was considered feasible if it did not delay surgery.

Exploratory aims included extensive correlative analyses of the pretreatment biopsy and post-treatment resected tumour including PD-L1 staining, multiplex immunohistochemistry and T cell receptor sequencing. An additional exploratory analysis looked at the degree of pathological regression. This was analysed by a lung cancer pathologist using a method previously reported for use in measuring response to neoadjuvant chemotherapy in NSCLC. Major pathological regression (90% or more) was defined as a resected specimen with less than 10% remaining viable tumour cells.

The study included 20 patients who had a tumour biopsy taken. They then received two doses of nivolumab at four and two weeks prior to surgical resection of the tumour.

The results in the first 16 patients were presented today. The investigators found that there were no significant safety concerns and no delays to surgery with nivolumab.

Six of 15 patients (40%) had major pathological regression of their tumour following nivolumab. All of those tumours had dense infiltration of immune cells and either a complete pathologic response or isolated remaining tumour cells. An additional five patients had some regression of their tumour noted and evidence of immune infiltration. Multiplex IHC demonstrated infiltration of cytotoxic T cells into the tumours and also detection of new T cell clones in the tumour that did not appear to be present in the pre-treatment biopsy.

Forde said: "We found that neoadjuvant administration of nivolumab is safe and feasible in stage I-IIIA NSCLC and also a preliminary signal that anti-PD-1 immunotherapy may have activity in early stage lung cancer. Following these initial results we are expanding the study. One cohort will receive a third dose of nivolumab preoperatively and the other will receive the combination of nivolumab and ipilimumab preoperatively. This expanded study will continue to be conducted in collaboration with investigators at Johns Hopkins University and Memorial Sloan-Kettering Cancer Centre. Others, such as the Lung Cancer Mutation Consortium in the United States, are also conducting larger studies of neoadjuvant immune checkpoint inhibition in NSCLC."

Commenting on the study, Professor Pieter Postmus, chair of Thoracic Oncology at the University of Liverpool, UK, said: "There is a potential for bias when comparing a small biopsy, which might not represent the whole tumour, with the resected tumour. This is not a validated way to measure response to a treatment. It describes a biological effect but whether that has any clinical impact on survival is unproven."

"Although we do not know for the time being if a major pathological response is correlated with improved survival, this method could first be validated in a cohort of patients with advanced disease by comparing the percentages of viable tumour cells in tumour biopsies taken before and four to eight weeks after immunotherapy," continued Postmus. "If in this way regression - as defined in the preoperative study - correlates with survival in patients with advanced cancer, it is likely to hold true in less advanced or resectable patients. Long-term survival data will be the ultimate test for these neoadjuvant immunotherapy strategies."