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Abstract LBA41_PR - 'Neoadjuvant anti-PD1, nivolumab, in early resectable non-small-cell lung cancer' presented by Dr Patrick Forde during the Proffered Paper Session, Non-metastatic NSCLC and other thoracic malignancies on Friday, 7 October, 14:00 to 15:30 (CEST) in Room Madrid.
European Society for Medical Oncology (E. "Neoadjuvant immunotherapy prior to surgery is safe and feasible in early lung cancer." Medical News Today. MediLexicon, Intl., 10 Oct. 2016. Web.
"To help wherever I can, anyway I can."
As you may have noticed I love tigers, they are my passion!
I was born in the year of the tiger and have collected them my whole life.
Here are some pics I have, if you have any tiger pics you think I might like, please feel free to pass them on to me.
I try to do what I can for these magnificent creatures, and I hope that mankind doesn't wipe them out entirely.
WE NEED TO STOP KILLING THESE BEAUTIFUL ANIMALS!!
The following is a poem I wrote a long time ago for a friend.
I entered it into a contest online and actually made it into the finals!
I think the words suit the care2 site and all my friends on here perfectly.
Another year rolls by, Another battle won.
We've had disagreements, We've seen the rising sun.
Said goodbye to childhood, Locked up those carefree days.
Setting forth to new ones, Cold and thick with haze.
Although times are confusing and seem to be unfair.
I've got an ear to lend, Because I really care.
If you're ever down and out and everything offends.
Don't hesitate to call, In me you've got a friend.
About Me I am an honest, loyal, real down to earth person who loves this planet. Animals are a big part of my life, always have been, always will be. I try very hard to be mindful of the fact that we are all connected.
Wild Fact About Me I love to hand-raise/rehabilitate and rerelease wild baby animals. Squirrels and raccoons mostly.
My Philosophy What comes around, goes around.
What/who changed my life and why "Women who run with wolves"
I think all women should read this book, it will change their lives.
Quotation "We are not human beings having a spiritual experience, we are spiritual beings having a human experience."
As members of Rajya Sabha continued to disrupt proceedings over various issues, chairman Hamid Ansari, who was forced to adjourn the proceedings, deplored them for not allowing a discussion on the death of a student from Arunachal Pradesh.
Nido Taniam, son of an Arunachal Pradesh MLA, was allegedly beaten up by some shopkeepers in Lajpat Nagar area of south Delhi after he got into an altercation with them over their remarks on his hairstyle. He subsequently died on January 30.
As soon as the proceedings commenced, members from different political parties demanded a discussion on Nido Taniam.
AIADMK and Telegu Desam Party (TDP) members created noisy scenes on different issues even after Ansari agreed for the discussion as sought by various political parties earlier.
Ansari even asked Ravi Shankar Prasad of the Bharatiya Janata Party (BJP) to speak on the issue.
But, AIADMK members rushed to the Well protesting the arrest of Tamil fishermen by Sri Lankan authorities, while TDP members shouted slogans against the plan to bifurcate Andhra Pradesh.
"Can we not respect the dead even?" asked Ansari as the din continued.
He then adjourned the House till noon.
Rajya Sabha was adjourned till 2pm and Lok Sabha for the day as soon as the Houses reconvened for the second time.
Earlier, both Lok Sabha and Rjaya Sabha were adjourned till 12pm after an uproar over a variety of issues including the Telangana statehood and plight of Tamil fishermen.
As soon as Lok Sabha met for the day, several anti-Telangana members trooped into the Well holding placards and shouting slogans like 'Save Andhra'.
They were joined by members from erstwhile UPA ally Dravida Munnetra Kazhagam (DMK), who were demanding "justice" for Tamil fishermen languishing in Sri Lankan jails.
Some Samajwadi Party members also rushed to the Well but their demand could not be heard in the din.
Amid the pandemonium, speaker Meira Kumar adjourned the House till noon.
For Hurd and Yearick, they are making a habit of trips to the Giant Center in Hershey as they were both there last year.
For Powers and Dowling, this is a historic trip as they are the first St. Joseph’s wrestlers to reach Chocolate Town.
Yearick and Powers cruised to the 120-pound semifinals.
Yearick pinned his opening opponent in 59 seconds. He then used a dominating 9-0 major decision over North Star’s Keaton Furry, who was the District 5 champion.
Powers opened the day with a 9-2 victory over Gary Loeffler from South Fayette. In the quarterfinals, Powers took care of District 6 foe Conne Polacek of Westmont Hilltop 6-0.
Hurd and Dowling had to gut out quarterfinal wins to reach the 145- and 132-pound semifinals, respectively.
After opening the day with an 11-2 major decision, Dowling used a late score to reach the semifinals.
Trailing 1-0, the freshman hit a reversal with about 25 seconds to go in the match. His opponent needed injury time with 15 seconds to go. Dowling said he started talking to himself.
Dowling came out of that injury time with a solid 15-second rideout and the 2-1 win. Dowling’s win remind St. Joseph’s coach Pat Flynn about something that happened earlier in the week.
Hurd was in the same situation as Dowling. He trailed 1-0 late in the second period. He was able to get a takedown and opened the third period with a 2-1 lead.
Hurd started in the bottom position. He collected a reversal with 25 seconds to go for the 4-1 win.
Penns Valley has three others alive in the consolation brackets. Baylor Shunk (106), Andrew Sharer (152) and Abraham Allebach (160) remain in the hunt. They each need just two wins on Saturday to punch their tickets.
The Wolves also have their other two wrestlers in Ethan Kauffman (106) and Evan Courts (138) alive. Flynn was very happy with how the first day ended up but knows there is still work to be done.
A Ferris wheel for downtown Boston?
Proposal to spruce up City Hall Plaza includes an "observation wheel," a pop-up beach and a windy ice skating track.
The summertime proposal includes an "urban beach" and boardwalk.
More from the Delaware North Cos. bid to revitalize City Hall Plaza.
Boston over the years has found many creative ways to spruce up the bleak brick desert that is City Hall Plaza.
The wind-whipped slab in its time has welcomed thousands to the Boston Calling music extravaganza, a steady rotation of food festivals and, this summer, a giant carpet of Astroturf.
But soon, according to a proposal from the owners of the TD Garden, the plaza could welcome a towering Ferris wheel.
The city announced on Thursday it picked a bid from Delaware North Companies, the sports-arena’s operator, to revitalize the plaza for the duration of a three-year contract.
Among many ideas, the bid seeks to add a hip restaurant, a marquee with the word “Boston” in big block letters and a series of art installations - beginning with glowing, musical see-saws.
For the summer, the bid proposes an “urban beach” complete with sand and a boardwalk.
In the winter, plans include a windy ice skating track, curling rink, “winter cabanas” and places to warm up and drink hot chocolate.
None of those ideas are final.
The proposal would maintain the plaza’s status as a concert venue, and city officials have said work in the area would not cost taxpayer money.
Good sleep is highly important for our physical and mental health. While we slumber and rest, our body gets rid of toxins, repairs injury, and reduces stress. Staying up till late nights is considered as bad sleep pattern, which really interferes with natural sleep pattern and hinders all those processes which are very essential for natural repair of body and brain. A bad sleep pattern can lead to many types of disorders. Staying up till late nights, waking early on workdays and sleeping till late on days off may not be as restful as we think. A best healthy sleep pattern for us is designed by the nature, when we disturb it with our unhealthy sleep habits, our risk for diabetes and heart disease rises. The people with large differences in their sleep schedules on workdays and free days tended to have worse cholesterol and fasting insulin levels, greater insulin resistance, larger waist size, and higher body mass index (BMI).
Interference with natural sleep rhythms increases risk of heart attack, increases risk of breast cancer, increases risk of depression, increases risk of workplace injury, increases the risk of road traffic accidents, changes metabolism, increases risk of obesity and diabetes. Staying up in late night and sleep till late in day, can negatively affect a range of systems in the body. Not getting enough sleep at night prevents the body from strengthening the immune system and producing more cytokines to fight infection. This means a person can take more time to recover from sickness as well as having an increased risk of chronic illness. Unhealthy sleep pattern can also result in an increased risk of new and advanced respiratory diseases. Unhealthy sleep pattern can affect body weight. Two hormones in the body, leptin and ghrelin, control feelings of hunger and satiety, or fullness. The levels of these hormones are affected by sleep, that is the reason night owls often go out for having food in late night hours and then suffered from sleep deprivation. This situation causes the release of insulin, which leads to increased fat storage and a higher risk of type 2 diabetes. It also can affect hormone production, including growth hormones and testosterone in men.
There is a direct link between unhealthy sleep pattern and our mental and physical health, it also called “social jetlag” which refers to the mismatch between an individual’s biological circadian rhythm “body clock” and their socially imposed sleep timetables. Social jetlag relates to weight gain and some pointers of cardiovascular function. Unhealthy sleep pattern can contribute to metabolic problems, these metabolic changes can directly contribute to the development of obesity, diabetes and cardiovascular disease.
A bad sleep pattern weakens the ability of the part of the brain that handles reasoning, known as the prefrontal cortex, to control the emotional part, the amygdala. This leads to the abnormal processing of emotions. Good sleep is very essential to prepare the brain for learning. When the brain is deprived of sleep due to a bad sleep pattern, it is difficult for brain to concentrate and form new memories. When we stay awake till late night or significantly cut sleep short, the body does not release the hormones necessary to regulate growth and appetite, and instead of positive hormones our body forms an excess of stress chemicals, such as norepinephrine and cortisol. Unhealthy sleep pattern, sleep deprivation and short sleep durations are predictors of weight gain in adults and children. Each one-hour reduction in sleep time per day is related with an increase of 0.35 kilograms (kg) in our body weight. These changes result in increased risks for obesity, diabetes, hypertension, heart attack, and chronic sleep-deprivation.
Bad sleep pattern can have a profound impact on both emotional function and normal thinking abilities in healthy individuals, resulting in reduced tendency to think positively, bad moods, a decreased enthusiasm to solve problems, a greater tendency towards superstitious, illogical and magical thinking, intolerance and less empathy toward others, poor impulse control. The people with a sleep pattern against the nature rules are more likely to report increased feelings of worthlessness, inadequacy, powerlessness, failure, low self-esteem, poor job performance, conflicts with co-workers, and reduced quality of life. Finally, individuals with disturbed sleep pattern score higher on clinical scales measuring depression, anxiety, and paranoia.
Bad sleep pattern also leads to increase the risk of accidents. In our country most of heavy vehicles travelled during night hours, drivers, staff and passengers of heavy vehicles all are running against natural sleep pattern. Approximately, after 16 hours of staying awake, the body trying attempts to balance the need for sleep. If a person tries to resist the need of sleep and does not get enough sleep, the brain obtains sleep through short sleep attacks called microsleeps. This is an uncontrollable brain response that makes a person unable to process environmental stimulation and sensory information for a brief amount of time. A person’s eyes mostly remain open during microsleeps, but they are essentially “zoned out” and slept already. As the nature of these attacks is unexpected and sudden, the consequences of a sleep-deprived in an individual who is operating heavy machinery or driving can be catastrophic to the individual and as well as innocent passengers, co-workers and bystanders. Microsleeps will continue to occur despite person’s forced attempt to stay awake, and because of this inbuilt sleep mechanism, it is extremely difficult for an individual to remain awake for more than 48 hours straight.
Disturbed sleep pattern can be linked to serious accidents and poor job or school performances. It can significantly lower individual’s overall quality of life. Lack of sleep disturbs the brain’s ability to balance emotions and thinking capabilities, lowers the body’s natural defenses, and increases the chances of developing chronic medical problems. While the occasional poor night’s sleep is not a serious problem in itself, but persistent habit to stay up till late night, disturbed sleep pattern and sleep deprivation can be. Sure, there is no substitute for a natural and restorative sleep pattern. So, there is a need to create awareness in the society about the importance of a positive sleep pattern. A certain amount of care should be taken to prevent ongoing disturbed sleep pattern and sleep deprivation in individuals of all ages.
Unhealthy sleep pattern is a common problem in all classes of Pakistani society, especially people living in urban areas. Sleep pattern of new era is affecting majority of individuals at some point in their lives, school going children and young adults are more vulnerable. Although occasional sleep interruptions are generally no more than a nuisance. Ongoing bad sleep pattern, a routine of staying up till late nights and lack of sleep can lead to excessive daytime drowsiness, sleepiness, emotional difficulties, poor job performance, obesity and a lowered perception to quality of life. Having a bad sleep pattern alters normal functioning of attention and disrupts the ability to focus on environmental sensory input. It has been implicated as playing a significant role in tragic accidents involving airplanes, ships, trains, automobiles and even in heavy industrial plants. Children and young adults are most vulnerable to the negative effects of unhealthy sleep pattern.
The people who does not get enough sleep in night to stay awake and alert in day time, they begin to experience of sleep deprivation with severe symptoms of sleep loss, daytime sleepiness, yawning, moodiness, fatigue, irritability, depressed mood, difficulty learning new concepts, forgetfulness, inability to concentrate or a “fuzzy” head, lack of motivation, clumsiness, increased appetite and carbohydrate cravings. As a developing nation we have to do struggle more to get a respectful status among the developed nations, so as a nation we cannot afford all above mentioned sickness caused by our bad and unhealthy sleep pattern.
A healthy sleep pattern is a night sleep pattern, as per new research specific age groups are recommended for following specific sleep hours.
In our society majority of people may consider sleep as wasted time and purposely deprive themselves of sleep to pursue other things such as educational goals, or money-making pursuits. But this practice has the worst effect on their mental and physical health and also negative impacts on their educational and socio-economic growth. Others may unintentionally not get enough sleep because of demanding jobs, shift work or family obligations. Consistent sleep-wake patterns of going to bed late, waking up too early or sleeping till late in the day can lead to sleep deprivation, perpetuate the late sleep phase and the accumulation of sleep debt. Additional causes of sleep deprivation include depression, anxiety and other medical problems such as obstructive sleep apnea, hormone imbalances, and additional chronic illnesses.
Our behaviors during the day, and especially before bedtime, can have a major impact on our sleep. They can promote healthy sleep pattern or contribute to sleeplessness. Our daily routines, what we eat and drink, the medications we take, how we schedule our days and how we choose to spend our evenings, can significantly impact our quality of sleep. There is a term “sleep hygiene” which refers to a series of healthy sleep habits that can improve our ability to fall asleep and stay asleep. A natural and healthy Sleep pattern helps the heart vessels to heal and rebuild as well as affecting processes that maintain blood pressure and sugar levels as well as inflammation control.
In order to create awareness in the society about healthy sleep pattern, as a researcher in the field of public healthcare, I would like to suggest following 18 most important tips to adopt a healthy sleep pattern.
Realize the importance of early night sleep.
Keep a consistent sleep schedule. Get up at the same time every morning, even on weekends or during vacations.
Set a bedtime that is early enough for you to get at least 7 to 8 hours of sleep.
Don’t go to bed unless you are feeling sleepy.
If you don’t fall asleep after 20 minutes, get out of bed.
Establish a relaxing bedtime routine.
Make your bedroom quiet and relaxing. Keep the room at a comfortable, cool temperature.
Limit exposure to bright light in the evenings.
Turn off mobile phones, TV and other electronic devices at least 30 minutes before bedtime.
Don’t watch movies or late-night shows.
Don’t eat a large meal before bedtime. If you are hungry at night, eat a very light snack.
Stop habit of having heavy meals in mid-night.
Stop going out at roadside dhabaas, food courts, and restaurants in late night hours.
Get rid of the habit of checking refrigerator for food in the mid of nights.
Exercise regularly and maintain a healthy diet.
Avoid consuming tea or coffee in the late afternoon or evening.
Reduce your fluid intake before bedtime.
Know how sleep pattern affects our health.
Hollywood is still reeling from news that Angelina Jolie and Brad Pitt are divorcing – one of the most high-profile splits in recent memory. Now, new allegations that Pitt may have been abusive to their children could have an impact on legal proceedings.
Days after Jolie, 41, filed for divorce from the 52-year-old actor, requesting sole physical custody of their children, PEOPLE confirmed Thursday that Pitt is under investigation by the L.A. County Department of Children and Family Services for allegedly getting verbally and physically abusive with one of the couple’s six kids.
Legal experts say that the allegations may affect the divorce and custody of the couple’s six children (Maddox, 15, Pax, 12, Zahara, 11, Shiloh, 10, and 8-year-old twins Knox and Vivienne) – if the claims turn out to be true.
For more details inside Jolie and Pitt’s decision to end their marriage, pick up this week’s issue of PEOPLE.