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__label__wiki	0.998584	0.998584	Tony Abbott and Cory Bernardi clash over potential Liberal Party split 7:56pm Dec 30, 2016 South Australian Denator Cory Bernardi has hit out at Tony Abbott, claiming the former prime minister is the "only person" talking about a Liberal Party split. Mr Abbot urged "rebellious" conservative colleagues not to leave the Liberals and risk delivering government benches to Labor in an article for today’s issue of The Australian. Instead, he said it was better to "stay in and fight", in a message clearly aimed at conservative Senator Bernardi and other backbenchers. "If we think the party is headed in the wrong direction or is making a big mistake, our duty is to try to fix it, not to leave it," Mr Abbott wrote. "Any abandonment of the party would be a catastrophic mistake." The former prime minister later told 2GB radio there were "cross-currents" within the party and urged colleagues to think twice, not make a bad situation worse. "The conservative instinct is to fix things, not to junk them," he said. A feud is brewing between Senator Cory Bernadi and former prime minister Tony Abbott over a "Liberal Party split". (AAP) But Senator Bernardi hit back at Mr Abbott on Twitter, questioning his motives. Rumours have heated up in recent months the conservative firebrand is preparing to start his own party. Speculation was further fuelled by revelations Senator Bernardi's Conservative Leadership Foundation has registered a website for a political group called Australian Majority, after his Australian Conservatives network boasted it had signed up 60,000 people since July and promised "a massive 2017". Former speaker Bronwyn Bishop, who was dumped in April as the Liberal Party's candidate for her long-held seat, said Mr Abbott's article was unhelpful because it just added "fuel to chat". "It's a broad church, I'd like to see it stay that way and continue to work," she told Sky News of the party. Cabinet minister Scott Ryan echoed the broad church mantra, and said the party's culture of internal debate was one of its great strengths. "I don't think there are wings in the Liberal Party. I think there are individuals with liberal views on some things and conservative views on others," he told reporters in Melbourne. Senator Ryan urged his colleagues to heed the lessons of history, in particular the 1987 "Joh for Canberra" campaign that split the coalition and saw Labor elected with an increased majority. With AAP 6pm news Auto news: BMW i8 production to end in April - caradvice.com.au	cc/2021-04/en_middle_0086.json.gz/line1796920
__label__cc	0.580523	0.419477	Tom-Stade TOM STADE Monday 1 January 0001 - Saturday 16 February 2019 Doors: 6:45pmTime: 7:30pm Following last year’s smash-hit UK tour, the Canadian comedy legend is back with a new show. Welcome back to ‘I SWEAR TO…’ picking up just where he left off as an hour simply wasn’t long enough. Direct from the Edinburgh Festival, join Tom as he attempts to figure out exactly where he fits into this emerging new world of feelings and FaceTime. Exactly when did he, and all his stuff become vintage - and why didn’t he see it coming? Armed with his usual swagger and playful sense of mischief, join Tom as he explores these generational conundrums, and a whole lot more…. One of the most prolific and engaging stand-ups of our time. As seen on Ch4’s Comedy Gala, BBC One’s Michael McIntyre’s Comedy Roadshow, The John Bishop Show and Live at the Apollo (twice, bitches!) "Sack loads of charm. Poise and free-flowing spontaneity. Mischievous, high-spirited, no-nonsense stand-up from an expertly skilled Pro” Chortle “Every inch a star. If comedy is the new rock and roll, then tom stade is keith richards” “Huge presence. Really knows how to work a room. Attitude and energy. Properly hilarious, thoroughly enjoyable” “So cool he could well be the answer to global warming. Gloriously funny” Share TOM STADE with Friends...	cc/2021-04/en_middle_0086.json.gz/line1796921
__label__cc	0.683886	0.316114	Doggie Bath House: Alpharetta’s Best Dog Grooming And Spa ALPHARETTA, GA – January 20th, 2018 – Dog owners and their four-legged friends from Alpharetta and its surrounding areas have found a dog grooming and spa provider that stands out for its professionalism and impeccable services: Doggie Bath House. As part of its core principles, the Doggie Bath House puts pets over profits, and ensures that every pooch is both relaxed and spoiled while thoroughly enjoying a luxurious pampering session. The Doggie Bath House offers doggie baths, doggie grooms, and doggie spa days packages, while it can also arrange for pet sitting services, upon contact with the owners. The grooming center caters to the individual needs of each dog, helping in managing skin issues through medicated baths, and planning meeting sessions with timid dogs, prior to their grooming appointments, so as to help them acclimate to the Doggie Bath House surroundings. What makes the Doggie Bath House stand out is the fact that it is the only dog grooming facility in the area that includes doggie daycare with grooming services. The facility is clean, safe, and cage-less, ensuring that each pup enjoys a stress-free experience. Ms. Lisa Hawkins, the Doggie Bath House groomer specializes in Designer Breeds, and has been widely recognized for her skills and reviews. Ms. Hawkins has had the pleasure of managing and training veterinarians nationwide in their practice, while she has been a guest speaker at the Western Veterinarian Conference for many years in Las Vegas. What’s more, Ms. Hawkins’ while in corporate America worked with The Ohio State Veterinarian School, as well as UC Davis in California. “My extensive career, hobby and passion about grooming is rooted in my love for all dogs. At the Doggie Bath House, we welcome owners to come experience the knowledge and caring of our staff, and witness, firsthand, how we make every dog feel like home while with us,” said Ms. Hawkins. Doggie Bath House prioritizes giving back, offering a 10-15% of its profits to charities promoting the advancement of women, youth globally and the welfare of all animals. Those interested in booking an appointment should contact the business directly by calling at 770 – 802-5160 or by filling in the New Client Sign Up form found on the company’s website. To learn more about Doggie Bath House, please visit: www.doggiebathhouse.com Company Name: Doggie Bath House Contact Person: Lisa Hawkins Email: lisa@doggiebathhouse.com Address:3355 Highway 9 N City: Alpharetta State: Ga. Website: http://www.doggiebathhouse.com/	cc/2021-04/en_middle_0086.json.gz/line1796922
__label__wiki	0.665409	0.665409	Home Food Roulay Restaurant and Bar, a new Cajun-French restaurant finds its way to... Roulay Restaurant and Bar, a new Cajun-French restaurant finds its way to downtown Lexington Roulay Restaurant and Bar A new Cajun-French restaurant finds its way to downtown Lexington BY: KRISTINA ROSEN Filling the void of Cajun-French cuisine in downtown Lexington, Roulay Restaurant and Bar is preparing to open on West Short Street. Executive Chef Kelly Mackey and Nick Lagagsorn, owner of Buddha Lounge, are the creative masterminds behind Lexington’s newest upscale Cajun-French focused restaurant. Mackey was raised on Cajun and Creole food, and doesn’t hesitate to mention her deep Mississippi roots. She fell in love with French style cooking and honed her cooking skills while working as a sous chef at Le Deauville. After several years there, she opened her own food truck, Lady Remoulade, with the goal to find a business partner who was willing to invest in a Cajun-Creole food concept. She eventually found that business partner in Lagagsorn, whom shared her passion for bringing Cajun inspired cuisine to downtown in addition to her beliefs on how to treat employees. “I think as a team–me being back of house, him being in front of house–we have a lot to offer Lexington,” says Mackey. “I had this dream of creating this environment, this healthy family oriented restaurant environment. Nick was gracious enough to let me live out my dream. I honestly couldn’t have asked for a better partner on this journey.” A dream for them both, Mackey and Lagagsorn are quick to admit that Roulay didn’t happen overnight. The project took roughly two and a half years from conception to completion. The building, formerly home to law offices, but the space has been gutted and completely remodeled. The first floor features an intimate dining and bar area, two garage style doors that open into the street, and plenty of seating. With a heavy French southern vibe, the restaurant makes you feel like you’re tucked away in a cozy, authentic restaurant in downtown New Orleans. The second level is a lounge that features an original mural done by Joe King of Oracle Tattoo Guild and the third level is a patio. There are plans for live music events in the lounge and access to the patio during warmer weather. “We gave Joe some ideas and vibes we were going for — magnolia flowers, masks, feather–and we let him design it himself,” explains Mackey. “It turned out better than our expectations.” Mackey describes Cajun and Creole cuisine as country comfort food with the flair of culinary art. While she is a fan of other local Cajun offerings, she plans to elevate the staple dishes that Lexington knows and loves while infusing French techniques. “The menu is designed with Lexington’s palette in mind,” says Mackey. “Even the dishes you’ve never heard of or tried before, just give it a shot.” The restaurant will be open for breakfast, lunch and dinner. Breakfast will include beignets, pastries, and chicory coffee. Rachel Chancellor is the Pastry Chef behind the breakfast items and upcoming dessert menu that includes vegan and gluten free options. Lunch features traditional rice bowls like étouffée, gumbo, and jambalaya along with po boy and muffuletta sandwiches. While lunch is casual, dinner switches to a more fine dining experience. With a heavy French-Creole influence, the dinner menu features alligator, turtle soup, and seafood pasta dishes. Roulay is a female-run kitchen with a big focus on attention to detail. Mackey claims to cook grandma style, meaning very small batch quantities and fresh ingredients. Being so landlocked in Kentucky, she wants to offer high end menu items, show them off, and execute them right. As a scratch kitchen among many others in downtown Lexington, Mackey isn’t worried about competition. She thinks more and better offerings only elevate the local food scene. Mackey continues, “And with us, our food is so different. The neat thing is we’ve been welcomed into the community not only because we’re a scratch kitchen, but because we are different. The more amazing restaurants that come up in Lexington, the better.” Roulay Restaurant and Bar opens at 107 W. Short Street in February. Subscribe to the Ace e-dition for Lexington news, arts, culture, food, and entertainment news delivered to your inbox. Call today to advertise in Ace, 859.225.4889 Previous articleWhat’s Open, What’s Closed on Presidents’ Day 2020 in Lexington, KY? Next articleWho is playing at Forecastle 2020? Kristina Rosen Guidelines for Ace Palindrome Project on 1.20.21 What’s Open, What’s Closed on Martin Luther King Day 2021 in Lexington, KY? Lexington Vegan Week kicks off in January 2021	cc/2021-04/en_middle_0086.json.gz/line1796924
__label__wiki	0.744643	0.744643	Voting Rights Advocates Sue to Protect the Right to Vote of Missourians in the November 2020 Election September 18, 2020 - 12:00pm %3Ciframe%20width%3D%22560%22%20height%3D%22315%22%20src%3D%22https%3A%2F%2Fwww.youtube.com%2Fembed%2FDlm7mZ6uTN0%3Fautoplay%3D1%26version%3D3%26playsinline%3D1%22%20frameborder%3D%220%22%20allow%3D%22accelerometer%3B%20autoplay%3B%20clipboard-write%3B%20encrypted-media%3B%20gyroscope%3B%20picture-in-picture%22%20allowfullscreen%3D%22%22%3E%3C%2Fiframe%3E Privacy statement. This embed will serve content from youtube.com. "Challenge seeks to streamline processes absentee and mail-in ballots and ensure counting of ballots cast by valid voters." ST. LOUIS, MO—Today, the Organization for Black Struggle, Missouri Faith Voices, the St. Louis and Greater Kansas City Chapters of the A. Philip Randolph Institute, and the National Council of Jewish Women St. Louis Section filed a federal lawsuit against Missouri Secretary of State Jay Ashcroft and Missouri’s 116 local election authorities alleging that the state’s absentee and mail voting systems place unlawful restrictions on Missourians’ right to vote. The American Civil Liberties Union of Missouri, Dēmos, Lawyers’ Committee for Civil Rights Under Law, and the Missouri Voter Protection Coalition jointly represent the Plaintiffs. In the midst of a global pandemic when more people than ever are casting a ballot outside of their Election Day polling place, Missouri has constructed barriers to the ability of people to request and cast an absentee or mail ballot, and then have that ballot counted. The case, filed in the U.S. District Court for the Western Division in Missouri, seeks relief for aspects of Missouri’s absentee and mail-ballot provisions, specifically differing rules for requesting and returning mail-in ballots compared to absentee ballots; and rejection of absentee and mail-in ballots for minor deficiencies in ballot envelope forms, without consistent notice and cure guarantees for voters. In June 2020, Missouri, which only allowed people to cast an absentee ballot if they could proffer one of a limited number of excuses, temporarily extended opportunities to vote absentee, and also created a new category of remote voting (referred to in the state as “mail-in voting”) that is open to all registered Missourians in 2020 due to the pandemic. The law restricts how mail-in ballots may be requested and returned that do not exist for absentee ballots, increasing the risk that people who vote a mail ballot will be disenfranchised this November, and fails to provide basic procedural safeguards to prevent rejection of mail and absentee ballots. Missouri allows absentee and mail ballots to be rejected for minor errors not material to the voter’s eligibility and fails to ensure voters have opportunities to correct errors or omissions on their ballot envelope statement. Eligible voters can have their ballot rejected without notice or opportunity to cure defects—and may never learn their vote was not counted. While some jurisdictions attempt to alert voters to such deficiencies, there are no required procedural protections prior to rejecting a voter’s mail ballot, leaving many Missourians no means to cure ballot envelope statements without having to travel to their local board of elections in person. These burdens on the right to vote already disenfranchised scores of voters during the August 2020 elections, including first-time voters, Black and brown voters, and older voters, some of whom were quarantined in senior living facilities. Plaintiffs seek declaratory and injunctive relief for Missouri voters on these issues in advance of November’s election: allowing mail-in voters to request and return ballots in the same manner as absentee ballots, enjoin rejection of ballots for non-material deficiencies on the ballot envelope; and give voters opportunities to notice and cure any deficiencies. The voting rights and public interest organizations involved in the lawsuit issued the following statements in response: Rev. Cassandra Gould, Executive Director of Missouri Faith Voices: “In Black and other communities of Color in Missouri, the onset of the pandemic meant a struggle for access to life or death COVID testing due to no clear direction from elected officials. As people of faith, leaders at Missouri Faith Voices and other community partners were overly burdened with caring for the most vulnerable residents of Missouri. This election season is no different. Our communities are struggling to access democracy due to negligence of those responsible for ensuring all voters have uninhibited access to the ballot box. For Missouri Faith Voices these are both moral issues. We will continue to work to ensure that democracy is not impaired, but we also believe that elected officials have a moral responsibility to all of the residents of Missouri and we will work tirelessly to hold them accountable.” Jamala Rogers, Executive Director of the Organization for Black Struggle: “The pandemic has uprooted our lives in ways we never imagined and that includes the voting process. It appears that instead of trying to make this critical process safe and seamless, government officials have added a layer of stress and vulnerability, especially for African American communities. Neighborhood mailboxes being removed, polling sites closed abruptly, confusion around mail-in voting are just a few examples of barriers that Black voters are facing in 2020. This is unconscionable.” Keith Robinson, President of the A. Philip Randolph Institute’s St. Louis Chapter: “In the midst of a global pandemic that has disproportionately impacted Black and Hispanic individuals, Missouri is constructing unnecessary barriers to the ballot that are forcing people to decide between their vote and their health. This violates the basic promise of a democracy. While APRI St. Louis is committed to helping individuals navigate the absentee and mail voting systems, it is incumbent on the State of Missouri to do better.” Patricia A. Jones-Macklin, Vice President of the A. Philip Randolph Institute’s Greater Kansas City Chapter: “When it’s citizens are struggling to remain afloat in the midst of a public health emergency, economic downturn, and record unemployment, Missouri should be making voting easier, not harder. The fact that Missouri has constructed what are sometimes insurmountable hurdles to people being able to vote by mail or absentee is indefensible. And, as past experience has shown this will result in disproportionately silencing the voices of Black voters and other voters of color. We will fight Missouri’s system of voter suppression and continue to work for an inclusive democracy.” Ellen Alper, CEO of the National Council of Jewish Women St. Louis Section: “Voting policies in Missouri have disproportionately impacted many groups of individuals, including, but not limited to seniors, people of color, disabled, those at greater risk of COVID complications and more. We need to assure that every vote counts, no matter how it is delivered to the local election authority. It is incumbent upon all of us to make sure that everyone who is eligible to vote can cast their ballot in a way that they feel safe. Since our founding in 1895, NCJWSTL has worked to promote voting rights by advocating for women’s suffrage, the Voting Rights Act of 1965, the Motor Voter Act, and beyond. NCJWSTL believes that our vote is our voice, and our democracy is at its strongest when every voice is heard. This lawsuit is critical to make sure that voting rights in Missouri are protected and that every vote is counted.” Denise Lieberman, General Counsel for the Missouri Voter Protection Coalition: “Hundreds of thousands of Missouri voters – disproportionately voters of color, first-time voters, seniors, and other vulnerable populations - will need to cast their ballot remotely in the November 3, 2020, election. Voter advocates in Missouri urged lawmakers to take steps to ensure all voters could safely access and cast ballots amid this pandemic. Instead, Missouri implemented a needlessly restrictive, confusing, and complicated mail-voting scheme. Missouri's needlessly restrictive and confusing rules and lack of basic notice and cure opportunities will cause valid Missouri voters to have their ballots rejected for reasons such as mail delays outside their control or minor mistakes unless the courts step in to ensure all valid votes can be counted.” Naila Awan, senior counsel at Dēmos: “At a time when people are struggling to find work and keep their families afloat, Missouri has chosen to make what should be the simple act of casting a ballot unnecessarily complicated and burdensome. It has elected to construct a system of voting that we know will make it harder for Black and first-time voters to have their voices heard in this November’s election. And it does so in the midst of a global pandemic that has sharply exposed the systemic inequalities that exist in our nation. This is antithetical to the basic understanding of how a democracy should and must function.” Tony Rothert, legal director of American Civil Liberties Union of Missouri: “As November approaches Missouri’s years-long campaign to make voting difficult is running headlong into the state’s blundering response to the pandemic. Because Missourians’ right to vote is endangered, we are headed to court.” Kristen Clarke, President and Executive Director at the Lawyers’ Committee for Civil Rights Under Law: “Missouri is known as the Show-Me State, which may explain why the secretary of state and election official’s actions show so little regard for the absentee voting rights of millions of their citizens. By rejecting mail-in ballots for trivial reasons, state officials are depriving Missouri citizens of their right to participate fully in the election amid an ongoing public health crisis.” pdfOBS vs Ashcroft.pdf	cc/2021-04/en_middle_0086.json.gz/line1796925
__label__wiki	0.799745	0.799745	What’s Coming To Disney+ In January DISNEY+ NEWS WHAT’S NEW ON DISNEY+ COMING SOON TO DISNEY+ WHAT TO WATCH ON DISNEY+ DISNEY+ LIBRARY Fantastic Four (2005) Review What's On Disney Plus > Blog > Brands > 20th Century Studios > Fantastic Four (2005) Review A group of four family and friends go to space and develop superpowers they must use to defeat a rich scientist who went on the space mission with them in the 2005 film, “Fantastic Four.” The film based on the team of Marvel superheroes is the second attempt to make a movie based on the team and the first to actually see the light of day. This is a weird film for me. It’s reputation is one of the disappointing film, but it was successful enough to get a sequel. I always end up enjoying myself whenever I watch this film, but when I’m not watching it, but thinking back on it, I remember it as not being very good. Maybe this is one of those bad films that I’m just able to have fun with. Maybe it’s better than we give it credit for. Either way, it’s definitely better than the attempted reboot in 2015. There are two parts of the cast that I truly enjoy. A pre-Captain America Chris Evans plays Johnny Storm, also known as the Human Torch. The Human Torch was my favorite part of the “Fantastic Four” comics and the “Fantastic Four” cartoon of the 90s. I think Evans does a great job of capturing his spirit and personality. There’s clearly something special in him that shines beyond this film. You can see the future star he would become, but we had no idea he would be easily recognized as Captain America. The other cast member who stands out to me is Michael Chiklis as Ben Grimm, also known as the Thing. While Chiklis just seems like himself when playing Grimm before the accident that gave him powers, he does an excellent job in making you believe he is the Thing. While Evans and Chiklis are great in their roles, the other three main stars leave a lot to be desired. Ioan Gruffold is a perfectly fine actor, but he does a terrible job as the leader of a superhero team. As Reed Richards, I believe Gruffold as a scientist hoping to learn more about cosmic energy clouds. But, I can’t believe him as Mr. Fantastic. The character has always been kind of silly because of his powers, but Gruffold doesn’t make the silly work for him. Meanwhile, Jessica Alba doesn’t really shine as the Invisible Girl. This is another case of an actress not right for the role. She isn’t a great superhero female lead. She’s not bad, she’s just not good. The real problem with this film is Dr. Doom. Julian McMahon is an excellent actor and Dr. Doom is one of the best Marvel villains, when written correctly. This one falls on the scriptwriter. McMahon did his best to make a poorly written role into a threat, but he just came across as cheesy. The writing for this character is a disservice to both McMahon and Dr. Doom. At the end of the day, I still had fun watching this film again. Despite all my critiques of this film, I enjoyed it once again. But, looking back on what I watched, it was really dumb. I’m not sure where this falls in the realm of superhero movies. If it were in the MCU, it would be the worst of the bunch. But, as 20th Century Fox production, it’s somewhere in the middle. I’m not sure why I enjoy it when it’s on, but I do, and I’m glad I took the time to watch it again. Ranking: 2.5 stars out of 5 What do you think of “Fantastic Four?” Sign up for the Disney Streaming Bundle (Disney+, ESPN+, and ad-supported Hulu) now through Hulu Jeremy Brown Jeremy has been a big Disney fan since he was a kid growing up during the Disney Renaissance. One day he hopes to go to every Disney Park in the world. 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How Much Is Disney+ How To Watch Disney+? Can I Download Movies & Shows On Disney+ ? What Won’t Be On Disney+? Will Disney+ Include 4K Video? How To Cancel Disney+ Why Are Movies & Shows Removed From Disney+ ? Star FAQ What Is Star? Why Isn’t Star Available On Disney+ In The US? How Much Is Disney+ Star Cost? What Is Star+? What Movies & Shows Will Be On Disney+ Star? What’s On Disney Plus covers everything to do with new Disney’s Streaming Service, Disney+. We cover the news, previews and what’s available on Disney+ and much more. Like our content? Please consider supporting us via Patreon JOIN OUR DISNEY+ FACEBOOK GROUP What’s on Disney Plus (WhatsOnDisneyPlus.com) is a unofficial fan site and is not endorsed, moderated, owned by or affiliated with Disney in any capacity. This site includes affiliate links. If you buy something through one of these links, we may earn an affiliate commission.	cc/2021-04/en_middle_0086.json.gz/line1796934
__label__cc	0.694455	0.305545	The Year Of The Pivot: How Agencies Adapted Their Strategies In 2020 by AdExchanger Content Studio // Thursday, December 3rd, 2020 – 6:00 am This article is sponsored by Criteo. As brands have reevaluated how they communicate in unprecedented times, agencies have spent the better part of 2020 adapting their strategies to fit into this new reality. Understanding changes in consumer behavior, improving the consumer experience and fostering industrywide collaboration have each emerged as key initiatives in service of this larger mission. Over the past several months, powerful insights across these categories have crystallized into new best practices that promise to live on long after the coronavirus is gone. Here are a few of the ways forward-thinking agencies have adapted this year – and how they plan to continue evolving as we head into 2021. Navigating shifting consumer trends It’s no secret that consumers have shifted their daily routines since the onset of the global pandemic – everything from how they eat, shop and connect with loved ones has changed. Based on data from 856 of Criteo’s retailers, ecommerce transactions in October saw a 28% year-over-year increase in the United States. Additionally, according to Nielsen, in-streaming consumption across all video has increased 74% amid the COVID-19 pandemic. According to Jason Crawford, VP, head of display, US, iProspect, these changes are necessitating new methods to target the right consumers and drive demand. “In an increasingly dynamic and competitive ecommerce market, as we’ve seen over the last few months, using sophisticated data signals and message personalization has been key for us to accelerate demand and sales for our clients in 2020,” Crawford said. “By partnering with Criteo, the iProspect team has been able to provide our clients with better insights regarding relevant shopping behaviors leading to more informed targeting and ultimately, tailored creative that is optimized to drive the desired consumer behavior. “We look forward to seeing what new behaviors consumers will adopt as we head into 2021, and how we can help our clients succeed in reaching them within relevant content and brand-safe environment that drives performance.” Prioritizing the consumer experience In response to COVID health concerns, shelter-in-place orders and other factors, consumers have rapidly shifted their lives online. To keep up with these trends, the ad tech space has shifted as well. Now, as consumers become savvier, vendors and marketers are expected to deliver a more personalized experience than ever before. Marketers need to stay connected at every step of the consumer journey to remain relevant and avoid the risk of being forgotten. “The rapid acceleration of the commerce industry has blurred more lines and opened up possibilities for new collaborations, activations and connection points with the consumer,” said Amy Lanzi, EVP, North America Practice Lead, Publicis Commerce. “Our goal as marketers and agencies is to maximize these opportunities and super serve the consumer at every part of their journey – adding value along the way. Putting consumers at the center has always been a priority for Publicis Commerce and leveraging the right data can help us ultimately build and nurture the unique relationships our clients have with their customers.” Collaborating to find a new identity solution At the beginning of this year, Google announced that it will begin deprecating third-party cookies on Chrome in 2022 – instantly starting an industrywide countdown. While this presents the ecosystem with the challenge of finding an alternative to third-party cookies to ensure advertisers reach their target audiences, it also presents an opportunity to create an even better solution that benefits consumers – as well as advertising players. To do this, the industry is coming together in ways it never has before to discuss various options and promote testing and adoption to advertisers and publishers. According to Kolin Kleveno, SVP, Addressable Audiences at Tinuiti: “As the industry looks to an alternative to third-party cookies, it’s been incredibly encouraging to see the collaborative nature between brands, agencies, ad tech vendors and publishers in finding a new solution for identity. There will likely be a handful of solutions that will end up being adopted, so it’s critical that all sectors of the ecosystem join forces to collectively reimagine digital advertising. At Tinuiti, we’ve committed to preparing our clients with the right information and tools to help them effectively reach consumers online.” In practice, collaboration has taken different forms – including technology consolidation. For example, Criteo's recent collaboration with The Trade Desk centered on an agreement to join Unified ID 2.0, an industrywide initiative that will create a streamlined and scalable identity solution across the ecosystem. This identity solution puts consumers in control with a proposed transparency portal, enabling them to define and manage their advertising rights and preferences and data privacy. This makes it obvious how and why people are being advertised to. For example, if they said yes to personalization, they know why the site that they’re on is allowing a personalized ad to be delivered. In many cases, it is still early on in the solution-building phase. Next year is positioned to become a year of action, as vendors and agencies take the things they have learned this year and continue to adapt them into strategies that will delight customers and drive success. Cast Away But Not Lost: How Publishers Can Navigate Their New Surroundings A Review Of Key Terms And Emerging Best Practices In Connected TV As Ad Spending Falls, Savvy Marketers Turn Focus To Optimizing Cross-Platform Reach Dovekey Privacy Sandbox Proposal Could Represent A Mini Detente Between Google And Ad Tech SSP PubMatic Files For $75 Million IPO	cc/2021-04/en_middle_0086.json.gz/line1796942
__label__cc	0.64178	0.35822	What ADI Doctors Had To Say Western Province, PNG The ADI team are enthusiastic and energetic and treat hundreds of people during each remote patrol clinic. I remember being very busy most days. While on patrol, our maternal and child health nurse does pap smears, STI checks and immunises children where possible. The Physio sees patients with back and knee pains, teaching them how to lift properly and do simple rehabilitative exercises. They often find disabled people they did not previously know about, and arrange for appropriate equipment to be delivered and follow up care. Our Dentists visit local schools and screen hundreds of children, as well as treating adults at our clinics. And our Doctors deliver babies, reset bones, diagnose a variety illnesses and conditions and work to upskill local health workers to ensure communities have ongoing medical support once the ADI team has moved on. I have many good memories of both the times I volunteered in PNG. I was always looked after very well – receiving advice of the best way to wash while wearing a ‘lap lap’ (sarong), making sure I was safe if I had to use the outdoor toilet pit late at night, and trying to teach me Pidgin (my attempts at saying many of the words were a source of great amusement). Dr Jenny Hamper New Ireland, PNG Living and working in PNG is an amazing experience. In your free time there’s lots to do – there is swimming in the ocean or beautiful rivers, diving, surfing, and birdwatching. One of the highlights for me was being a part of a traditional canoe race. Food wise, the prawns, lobster and fish are amazing. And the people are so welcoming. The local colleagues are just the sweetest people, always keeping an eye out for you and making sure you’re doing fine. Professionally, it’s amazing to fly into all these remote villages and very rewarding. You really visit the most health deprived people in PNG and there is a lot you can do. I liked that we were focused on the basics: water, sanitation, vaccination and training local health workers. Things which have long term health benefits. Working in PNG was a learning experience on many different levels. The patrol schedule was the biggest challenge, especially in the beginning. It was a challenge mentally and physically and was harder then I expected – sleeping arrangements were not always optimal for someone as tall as me! Sometimes street dogs would keep me awake as well. Despite this, I felt very safe and supported during my time in PNG and it is an experience that has challenged me and made me a better doctor. Volunteering with ADI is a life experience that’s unique. It’s sweaty, it’s exhausting, it’s amazing, it’s frustrating and it’s wonderful all in one day. And it has enriched my life in many different ways. I would definitely go again! Dr Roeland Kraan New Ireland & Western Province, PNG My six months with ADI was an experience I will always cherish. The medicine was not only eye opening, but served to provide me with a vastly different clinical mindset and understanding toward best patient care across multiple areas of medicine. I had the opportunity to examine and treat patients with diseases that virtually don’t exist in developed countries, including malaria, tuberculosis, leprosy, filariasis and yaws. Nothing had prepared me for the sheer isolated and untouched paradise of New Ireland Province – sandy beaches, tropical rainforest, miles of un-spoilt reef and traditional villages. The place was simply unbelievable and I was lucky enough to live alongside the local people and enjoy and appreciate firsthand the traditional way of life that still exists. Dr Tim Baird New Ireland Province PNG We live in a wonderful privileged bubble in Australia, we are so so lucky and we seem blissfully unaware of this fact. Within two hours flight from my home I can step onto a totally different planet, a parallel universe, it is surreal. I am so blessed to have been given the opportunity to work in PNG, to ignite a passion for teaching, to have received in abundance and to have pushed myself beyond my limits. We can, with the help of ADI, continue to teach, advocate, support, save lives, lead and just be there for the people of our closest and neediest of neighbours. Dr Merrilee Frankish New Ireland Province, PNG I was ADI’s first volunteer doctor to work in New Ireland, and I went again in 2013 which speaks for itself! I have done several other volunteer doctor jobs overseas and I thought this one was the most useful and rewarding. ADI is a small organisation and its management are very hands-on and involved. They are keen to get your ideas, feedback and suggestions. As a volunteer doctor you work closely with the local health staff ‘on the ground’ at health centres and with the Provincial Health office. You see and treat patients clinically who desperately need some medical help – but you don’t ‘take over’ from local staff. New Ireland is beautiful and you’ll be treated to delicious fresh fish and some fruit and veg. Also, you might love the heat and humidity! I’d thoroughly recommend volunteering with ADI to any doctor, nurse or health administrator who wants to work with patients in need and is keen to work alongside the local health staff. Dr Liz Scott Patience, diplomacy, flexibility and a willingness to get ‘stuck in’ is what is needed to really enjoy your time in PNG. There is certainly no shortage of variety: one day immunising children in remote villages and the next participating in health planning meetings with church and government officials. If you want to use all of the life and professional skills you have – and find a few new ones – then this is an opportunity to grab with both hands. Louise Devereux RN, Western Province and New Ireland Province, PNG My 3.5 months with ADI was an incredible and adventurous experience that has left a profound impression – I think about it every day. I was pushed beyond my physical and professional comfort zones many times, but ultimately those experiences gave way to the greatest sense of achievement and satisfaction. I now feel more skilled and confident as a practitioner. ADI has deservedly built up a good reputation and a great deal of respect in the Western Province. It’s sometimes hard to believe the extraordinary discrepancies between our lives and the lives of our nearest neighbours in PNG. Although the overall situation seemed bleak at times, there were many examples of hope and progress, and a sense that so much can be achieved. Dr Denise Wild (with husband Marco Sartori who joined her on assignment) Everything about PNG is an experience like never before: trekking through jungle to villages that have never seen a doctor; hours on a dinghy on the Fly River en route to remote villages with breathtaking scenery and sunsets; seeing leprosy, filiarisis and other tropical diseases in actual patients and not just in textbooks; working at a grassroots level with local staff and communities; sleeping in traditional huts and eating local food. Things don’t always go according to plan, but that’s all part of the adventure. Bring an open mind, a sense of adventure, tons of patience and a friendly smile. Dr Verena Doolabh Some days it’s like a big adventure: rivers and jungles, boat trips, bush hikes and meeting people whose lives are so very different from mine, yet in many ways so much alike. If you are after an adventure, if you want to contribute to a team effort, if you want to do your bit with others who have given the best part of a lifetime to mission work, if you want to see how the other half struggle through life, if you want to see an ancient culture in our nearest neighbour, if you have patience, tolerance and persistence and you want to be challenged in all these areas, then come. Dr Margaret Purcell It tested my clinical decision-making, my medical judgement and my ability to improvise solutions. There were no x-ray machines in Kiunga, very limited pathology testing, and at times no batteries for torches (…) You could do a career here in Australia and still never see some of the medical conditions that I saw over two months in PNG. Dr Emily Yeoh I just love the out-of-town clinics. Here, it’s more about chronic pain and chronic bronchitis, TB and congenital defects in kids, and of course the occasional leprosy patient (…) The belief in custom is strong – no death is natural, and Western medicine is viewed skeptically. And there are many different languages; it’s a different one in each village. Dr Siah Kim Working for ADI in PNG is about the medicine, the people and the place. It’s about pathology you will never see in Australia and it’s about life experiences that you will never have at home. You will be part of the lives of people who are socially and medically isolated and be part of the lives of people who are disenfranchised. You will learn about yourself and your limits. You will make a difference. A big difference. Dr Kate Napthali Opportunities in PNG – Apply Future Opportunities: Volunteer Doctors Senior Nurse/Nurse Practitioner Your Guide to Volunteering with Australian Doctors International (ADI) Complete the Online Application Form If you would like further information about these roles, please contact ADI: Email: hradmin@adi.org.au Phone: (02) 9907 8988.	cc/2021-04/en_middle_0086.json.gz/line1796943
__label__wiki	0.604809	0.604809	aenigma Muriel King Cover Girl – fashion goes to the movies Cover Girl is a 1944 movie in which Hollywood embraces the business of fashion. It offers an opportunity to take a look at the modeling businesps, then burgeoning but still in its infancy. And it provides a showcase for the fashions of the day and the talents of Rita Hayworth and a bevy of models. It’s a bright spectacle with songs by Jerome Kern and Ira Gershwin, costumes by Travis Banton, Muriel King and Gwen Wakeling, choreography by Gene Kelly and Stanley Donen, and that special early-Technicolor lushness. Donen would go on to direct Funny Face, another musical about the world of fashion, with Fred Astaire and Audrey Hepburn as its stars. Funny Face would help to cement the reputation of Paris after World War II as the world capital of fashion. 1943. Anita Colby – "the most beautiful face this side of heaven and the sharpest tongue this side of hell," according to Valdemar Vetlugen, editor... Cecilia Meagher 1943. Cecilia Meagher began modeling in 1936 when she was barely 17 years old. In the early 1940s she signed with Conover models. In 1942,... Leslie Brooks 1943. Leslie Brooks started her career around 1940 as a model. In 1941 she signed with Columbia and had a makeover: she changed her name... Peggy Lloyd 1943. Peggy was adopted age five by Harold Lloyd, a famous comedian, a shrewd investor and the richest man in Hollywood. Despite the family’s wealth,... Eileen McClory 1943. Eileen McClory is a vivacious, cute, girl-next-door type, so has just the kind of looks and personality that Harry Conover likes. So when she... Betty Jane Hess 1943. Betty Jane Hess began modeling in 1938, when she was barely 17 years old. Like many aspiring models, she competed in various pageants and... Dusty Anderson 1943. Dusty started out as Ruth Anderson from Toledo, Ohio. Harry Conover spotted her in New York “doing some designing”, decided that the name Ruth... 1943. With her hazel eyes and lithe figure, Jinx Falkenburg is one of America’s highest-paid cover-girl models during World War II and, with her... The plot of Cover Girl is both pure fantasy and pretty banal. A Brooklyn nightclub owner loves his principal dancing girl. The dancing girl loves the nightclub owner. But the dancing girl has a driving ambition to become a famous cover girl… Bear in mind that while the world of Cover Girl might feel like it has nothing to do with reality, former Vogue editor Rosamond Bernier would recall: Vogue was something in those days. I came in my first morning and saw all the editors at the typewriters wearing hats with veils and big rhinestone chokers and earrings. I looked with absolute wonder! To give you a flavour, here are three extracts from the movie 1. Put Me To The Test Set to Jerome Kern and Ira Gershwin’s Put Me To The Test, this number is one of the movie’s highlights: two phenomenally athletic and graceful dancers, a treacherous set (different levels, stairs, a ramp) and no quick cutting to mask mistakes. The supporting girls and the costumes are the icing on the cake. 2. The shoot So they’ve hammed it up for the movie, but this scene offers a light-hearted insight into the art behind the stills photography that is such a focus for aenigma. We see the make-up artist (remember Perc Westmore – the makeup king of Hollywood?), the hairdresser, the dapper photographer and his assistant, and the final product – the magazine itself. 3. The cover girls and round the mountain We’re in the Wheaton Theatre. The curtain goes up and an enormous lens is lowered onto a podium in the middle of the stage. Through the lens we see each cover girl in turn enter from the left and watch her pose full-length and close-up. Her session ends with a glimpse of the magazine cover on which she appears. The whole thing has a nice pace and wit. It's followed by the wonderful "round the mountain" scene in which Rita Hayworth dances down and back up a cloud-shrouded Art Deco mountain peak. In this version, the original soundtrack has been replaced by a Madonna mash-up with Victor Cheng. Cover Girl – the business of modeling In 1944, the modeling business in the US is dominated by two agencies. Mid-1940s. Andrea Johnson, John Robert Powers model. Read more. John Robert Powers has blazed the trail. In the 1920s as an out-of-work actor he finds himself using his network to help photographers find models. He spots a business opportunity and sets up shop. As he later recalls, he: …had their pictures taken, made up a catalogue containing their descriptions and measurements, and sent it to anyone in New York who might be a prospective client – commercial photographers, advertisers, department stores, artists. The depression that follows the 1929 stock market crash enables him to broaden his talent pool by attracting debutantes whose families are on their uppers. At the same time he works hard to make the business respectable. His success changes the social status of models. Society hostess extaordinaire Elsa Maxwell says that she might give a party without debutantes but she wouldn’t dream of doing so without inviting a few Powers Girls. The 1940s see Powers basking in the light of success and publicity and expanding his business portfolio. He has a radio show and writes a regular syndicated newspaper column, Secrets of Charm. Warner Bros release The Powers Girl (1943), a movie about two sisters living in New York and aspiring to become high-profile models. And Powers Girls are hired by the Hollywood studios and go out with and marry the rich and famous. In 1941 Powers publishes the first of many books, The Powers Girls. Promising “The story of models and modeling and the natural steps by which attractive girls are created,” it’s partly a behind-the-scenes look at the agency, partly a beauty and grooming guide, and partly a marketing piece. In 1943 he launches a correspondence course, including “practical hints about what men really do and don’t like.” Meanwhile, his wife begins teaching charm courses covering grooming, diction and coiffure, the first step along the road to a nationwide chain of John Robert Powers Schools. But Powers has taken his eye off his core modeling business and this provides an opening for a new competitor. Mid-1940s. Anita Colby, model, agent and businesswoman extraordinaire. Read more. Harry Conover begins his career in the modeling business as a model and works for John Robert Powers before deciding to set up in competition. He’s handsome, suave and unscrupulous, taking with him models Anita Colby, Phyllis Brown and her boyfriend, who agrees to invest in the start-up. The boyfriend is Gerald Ford and in 1974 he will become President of the US. Harry differentiates his agency from that of his erstwhile employer by promoting a different kind of model. He mocks the Powers Girls as “Adenoid Annies, rattling bundles of skin and bones.” Focusing on preppies and campus queens, he pioneers a new type of model – “the windblown outdoor girl”, in the words of Bob Fertig his head of promotion. Conover calls these recruits Conover Coeds, then Cover Girls – and that’s where Columbia’s Cover Girl gets it inspiration and title. While, taking his cue from Hollywood, Conover develops a habit of rechristening his models – including his future wife. In 1941, the winner of a Miss Atlantic City contest turns up at the agency. She introduces herself to Conover: “I’m Jessica Wilcox.” “You’re Candy Johnson,” he replies. “And your rate is $5 an hour.” He later shortens her name from Johnson to Jones because she has trouble remembering the longer version. By 1943, thanks to her looks and his promotion – including candy-striped outfits and calling cards – she is a top model. And in 1946 Conover marries her. But the marriage is fated from the start. Conover is always chasing skirt – seemingly out with a different model night after night. He is also less concerned than Powers about respectability – he has a much more laissez-faire attitude when playboys approach him for dates with his models. “Right in my own office we have the very thing that every man looks for, works for, fights for and dies for,” Conover says, just before being excommunicated by the Catholic Church. In 1952, having dropped out of the agency business and franchised his schools, Powers will move to Beverly Hills, where he will settle until he dies, age 84. Conover, by contrast, will die age 53, having succumbed to a classic combo of booze, lechery and profligacy. The modeling business, like the movie business, is unforgiving. It has a habit of chewing up its practitioners and spitting them out. Cover Girl – behind the scenes 1943. Filming a scene for Cover Girl. Photo by Ned Scott. Read more. Cover Girl has more in common with Gilda than their very different plots and styles might lead you to expect. Both are Columbia productions commissioned by Harry Cohn. Both are directed by Charles Vidor with cinematography by Rudolph Maté. And both have scripts by Virginia Van Upp. Cohn is known to be tightfisted but he makes an exception for Cover Girl. He sets aside no less than a million dollars for the production and accepts it going US $600,000 over budget, with the lavish dance numbers devised by Kelly in no small part to blame for the overspend. The movie is quite a coup for the Conover agency – a massive riposte to (and possibly inspired by) The Powers Girl, released the previous year. Harry Conover and Anita Colby are both employed by the studio as “technical consultants”. The latter is in charge of a troupe of Conover models who travel west from New York in a special railway carriage – a great publicity stunt that’s lapped up by the press. The girls are all excited about what lies in store for them in Tinseltown but they’re in for a nasty surprise. Harry Cohn has made arrangements to ensure that they stay out of trouble. Francine Counihan, one of the models and also Anita Colby’s sister remembers: Cover Girl was produced by Harry Cohn. Oh, he was a monster. He decided to put us all in one house together where he could see that nobody could get out. So we stayed in Marion Davies’ home in California. He only let us out to go shopping. And there they stay for months while Harry Cohn apparently searches for an actress to play the lead role. Surely he’s known all along that this is to be a vehicle for his studio’s leading star, Rita Hayworth? Perhaps he just likes the feeling of power over the girls. Rita and the gang 1943. On a lawn, presumably outside the studio, Rita Hayworth poses with the cover girls. It looks like the photographer must be perched in a... Lucky man! 1943. Some people have all the luck. Rita Hayworth gives Tech Sergeant Gordon L Smith a peck on the cheek. A caption on the back... 1943. The stars relax in the hot California sunshine during a break in filming. The maid (as usual) is uncredited. A caption on the back... Susann Shaw and Jinx Falkenburg, cover girls 1944. Two of the era's supermodels pose on the set of Cover Girl. Susann Shaw is taken with the fashion sketch she's holding, while Jinx... Anyway, whatever the reason, there’s a great story about how all the girls sneak out one night to go to a party. They have to return at intervals, one by one, to get past the security guards. To the guards’ growing consternation, each in turn announces herself as Anita Colby, who is the only member of the troupe allowed out. Inevitably, the last one back is the real Anita Colby. Meanwhile, Anita Colby, who also acts as the girls’ agent, makes the most of the stay by managing to book three magazine covers each for the girls. Her success with the press doesn’t go unnoticed and she’s appointed “Feminine Director” of the David O Selznick studio. Rita Hayworth – promotional shot for Cover Girl 1943. Photo probably by Ned Scott. 1943. Photo by Robert Coburn. Rita Hayworth in a scene from Cover Girl 1943. Photo by Ned Scott. One of those most closely involved with the way Rita looks in Cover Girl is Robert Coburn, head of Columbia’s Photo Gallery. In John Kobal’s biography of Rita Hayworth, Coburn talks about photographing Columbia’s biggest star: The contract I signed put me in complete charge of the studio’s stills department. Mind you, if I ever relaxed and let a bad picture of Hayworth or any other star out, Cohn would call me on the carpet immediately. In those days we had the Johnson Office, and if we had any cleavage showing the pictures would be sent back. The Code was very strict. Any sign of breasts, even the shadow between, had to disappear. A woman wasn’t supposed to have any. We spent all our time touching photos up. Hayworth didn’t need touching up. She didn’t treat herself badly, she wasn’t an all-night carouser, although naturally we had to watch for wrinkles under the eyes and around the neck. Of course, any skin marks, small pimples, we would take them out. I don’t remember Hayworth ever looking at a picture, I don’t think she ever cared how she looked in a picture. She’d come in once in a while and ask how they looked but she didn’t bother checking or approving them. That’s rare for women. Whereas Cohn was interested in her every minute of the day. He’d call whenever he knew from the call sheet that I was shooting her. They fought a lot. I told Cohn a million times that if he stopped picking on her I’d get what I wanted but he kept needling her and fitting in more hours. I’d usually talk to her all the time when I was photographing her, getting her in the mood. Then, I’d catch her at her peak. She had the famous Hayworth look, looking over the shoulder, and after doing three of those she’d had it. She’d say, “What do you want that for? Get something else.” She didn’t realize that she didn’t have that come-and-get-me look except in that one pose. 1941. Rita Hayworth contemplates her cover girl status. Photo by George Hurrell. Read more. Cover Girl – Rita learns new role “Cover Girl” – Rita learns new role is the title of an article that appears in the 18 January 1943 issue of LIFE magazine. Rita Hayworth is just a little bit bigger in the bust and in the hips than the average top-notch photographer’s model. The movie star is 35 in. around bust and hips whereas the average model is, at best. only 34. These extra inches, which look fine on Rita Hayworth, did not worry Columbia Pictures at all when they cast her for the lead part in their forthcoming movie, The Cover Girl. The movie, which goes into production soon, will tell about photographers’ models who appear on the covers of national magazines. In it Miss Hayworth will combine her looks, figure and talents with Technicolor, some songs and a complicated story about two cover girls, one of 30 years ago and the other of today. The second cover girl will be the first one’s daughter. Miss Hayworth will play both of them. When Miss Hayworth was in New York City recently, it occurred to Columbia Pictures that she ought to go through a model’s routine to see how a photographer’s model really worked. Miss Hayworth, who is a game girl, spent a full day working out of Harry Conover’s model agency, making believe she was a real cover girl. She learned that beauty is not enough. For $3 an hour – $10 an hour if in great demand – models work exhausting hours in front of hot lights and fussy photographers, always trying to be charming and intelligent. To get work they have to be on time for appointments, be well-groomed and sweet-tempered. They spend days tramping around from client to client just to keep up their contacts. They are on their feet so much, in fact, that after being a model for a few months a girl’s feet invariably grow a whole shoe-size bigger. The girls with Rita are Conover models, each chosen by a national magazine to play its cover girl in The Cover Girl. Being the star, Miss Hayworth will not represent any single magazine. This week, however, she is LIFE’s own cover girl. 9 September 1943. Orson Welles and Rita Hayworth get hitched. Read more. In fact during the shooting of Cover Girl it turns out that Rita has two new roles. The second is as the wife of Orson Welles. It’s no secret that the couple have been dating. Even so, when it happens on 7 September 1943 their marriage takes everyone by surprise. According to Lee Bowman, the day the teams are shooting the film’s wedding scene, Rita arrives on the set. She looked very lovely sitting there in her wedding dress [for the movie] while the crew were setting up. Rita sat there with her hands in her lap, her eyes very big and a lovely big pussy smile on her face. When any of us asked, “What is it, Rita?” she’d just shake her head and say, “Mmm, I’ve got a secret.” Wouldn’t say anything else. The first we knew what it was came during the lunch break when somebody brought us the papers with the headlines.” While Rita is on cloud nine, director Charles Vidor is anything but. According to the film’s producer, Arthur Schwartz: And you know who was terribly jealous and unhappy? The director. He had fallen in love with her. He came and cried on my shoulder and didn’t want to go on. He had to continue shooting every day and she was now married and looking more radiant all the time. She had a tremendous empathy, tremendous sex appeal. All those fifteen or so Cover Girls together didn’t have what she had. Cover Girl – just a piece of fluff? Cover Girl wins the Academy of Motion Picture Arts and Sciences’ annual award for Scoring of a Musical Picture. It is also nominated for Color Cinematography, Color Art Direction, Sound Recording and Best Song. Bosley Crowther, the influential film critic of The New York Times from 1940 to 1967, says in his review: The script is so frankly familiar that it must have come from the public domain. And the characters are as sleekly mechanical as only musical comedy characters dare to be. But it rainbows the screen with dazzling décor. It has Gene Kelly and Rita Hayworth to sing and dance. And virtually every nook and corner is draped with beautiful girls. Further, this gaudy obeisance to divine femininity has some rather nice music in it from the tune-shop of Jerome Kern. 1943. Photographer unknown. 1943. Rita Hayworth and models pose at the offices of Vanity magazine. This is just the epitome of mid-1940s chic in terms of both the... Heavenly sight 1943. In this ravishing fantasy sequence, Rita Hayworth appears at the top of a stylized Art Deco mountain down which she dances into the arms... Round the mountain 1943. Having indulged her admirers, Rita Hayworth dances back up to the mountain peak in a rain of golden snowflakes. The caption on the back... Later on, Arthur Schwartz, whom Harry Cohn brought in to produce Cover Girl, recalls: In spite of everything people have said about Harry Cohn, his vulgarity, his lack of education, neither of which was a unique characteristic among the men in his position – he had an instinct for quality. Cover Girl, as I made it, couldn’t have been made at WB: Jack Warner wouldn’t have had the taste somehow, while at Metro they would have overproduced it – too many girls and too many of everything. The magazines and models: Cosmopolitan, Betty Jane Hess; McCall’s, Betty Jane Graham; Vogue, Susann Shaw; Harper’s Bazaar, Cornelia B Von Hessert; Woman’s Home Companion, Rose May Robson; The American Home, Francine Counihan (Anita Colby’s sister); Mademoiselle, Peggy Lloyd; Glamour, Eileen McClory; Coronet, Cecilia Meagher; Liberty, Karen Gaylord; Redbook, Martha Outlaw; The American, Jean Colleran; Farm Journal, Dusty Anderson; Look, Cheryl (Archibald) Archer; Collier’s, Helen Mueller; Rita Hayworth. Collage copyright and courtesy of Blonde at the Film. In his programme notes for the BFI, director Karel Reisz observes: In Cover Girl we can see the transition from the old to the new taking place. Though its story has the usual backstage background, many of its numbers are staged in the open air and characters dance in it for the joy of dancing and as an expression of mood, not simply as professional performers. The design of costumes and sets moreover, is notably above the usual standard of the routine product. Cover Girl also saw the emergence of Gene Kelly as a choreographer playing the role which he has since played many times: he dances pieces of the ‘plot’ instead of interpolating numbers, and his style is that of a ballet dancer, not a ‘hoofer’. Gene Kelly and Rita Hayworth in Put Me To The Test Cover Girl – want to know more? Apart from the LIFE article, key sources are Michael Gross’ book, Model – the ugly business of beautiful women, and John Kobal’s biography of Rita Hayworth. You can find my favourite online article at Blonde at the Film. Other articles worth reading are at The Vintage Cameo and moviediva. And there’s also Caren Roberts-Frenzel’s beautifully illustrated Rita Hayworth: A Photographic Retrospective. For biographies of some of the cover girls, take a look at Those obscure objects of desire. 1944. Cecilia Meagher by George Hurrell. Read more. Other topics you may be interested in… Gilda – the movie that made Rita Hayworth into a bombshell Ludmilla Tchérina – a throbbing, pulsating dynamo The Lady from Shanghai – the weirdest great movie ever made Filed Under: Fashion, Films, Stars Tagged With: Andrea Johnson, Anita Colby, Arthur Schwartz, Betty Jane Hess, Bosley Crowther, Candy Jones, Cecilia Meagher, Charles Vidor, Columbia Pictures, Cover Girl, Dusty Anderson, Eileen McClory, Francine Counihan, Gene Kelly, George Hurrell, Gwen Wakeling, Harry Cohn, Harry Conover, Jinx Falkenburg, John Robert Powers, Karel Reisz, Leslie Brooks, Muriel King, Orson Welles, Peggy Lloyd, Rita Hayworth, Robert Coburn, Rosamond Bernier, Rudolph Maté, Stanley Donen, The Powers Girl, Travis Banton © 2021 - aenigma some rights reserved under a creative commons attribution-noderivs 3.0 unported license	cc/2021-04/en_middle_0086.json.gz/line1796946
__label__wiki	0.756657	0.756657	Africa Health Times Your Premier Health Newspaper! Africa Health Times - Africa's Premier Online Health Newspaper Africa CDC secures 270 million vaccine doses for African countries Nigeria to get 42m doses of COVID-19 vaccine COVID-19: South African President in self quarantine Nigerian health workers abandon patients on World Patient Safety Day SAM EFERARO THIS WEEK How my family and I survived COVID-19 – Bukky George, CEO, Nigeria’s… Nigeria marks 100 days of COVID-19 Asthma therapies can reduce risk of COVID-19 infection – Prof. Erhabor WHO certifies Africa free of wild poliovirus World AIDS Day: WHO Africa launches media campaign to inform youths World No Tobacco Day: WHO highlights huge scale of tobacco-related lung disease… WHO mourns doctor killed in DR Congo hospital attack Pfizer, BioNTech announce early positive date from ongoing Phase 1/2 study of… Novo Nordisk partners UNICEF towards ending global childhood obesity Nigeria: Sanofi signs pact with May & Baker for local drug production Johnson & Johnson recalls baby powder ANTI-CORRUPTION NEWS UNODC initiates new programme to assist Nigeria in crime prevention, drug use EDUCATIONLAW AND JUSTICE By Sam EFERARO On Jun 19, 2019 ABUJA – The United Nations office on drugs and crime Nigeria (UNODC) and the Federal Ministry of Education today launched a new programme, Education for Justice (E4J) Initiative in Nigeria, to help prevent crime, drug use and violent extremism among youth. The E4J initiative seeks to prevent crime and promote a culture of lawfulness through education activities and materials designed for primary, secondary and tertiary levels. With the introduction of the programme, UNODC will work with the Federal Ministry of Education as well as the United Nations Educational, Scientific and Cultural Organization (UNESCO) towards promoting the integration of crime prevention and other rule of law related topics into the education curriculum at all levels, through the sensitization of teachers, professors and policy makers and other stakeholders active in the education sector at Federal and State levels. Acknowledging the importance of the E4J Initiative, the Permanent Secretary, Federal Ministry of Education, Mr. Sonny Echono who was represented by the Director of Basic and Secondary Education, Mrs Lami Amodu, said “I am particularly delighted that this initiative is coming up at a time when the government is embarking on programmes and activities aimed at steering the youths to the right direction and consciously promoting culture of obedience to the rule of law, integrity, honesty, complete abhorrence to a life of drug, crime and criminality.” And while expressing optimism about the positive impact of the intervention and pledging the Ministry’s collaboration for the successful implementation of the programme, he said “The E4J initiative is expected to leverage on the existing government programmes in order to achieve the desired result of equipping students at all levels of education with requisite skills, attitudes and values reorientation to enable them function effectively and optimally in the fast-changing world.” In his keynote address, the Vice President, Prof. Yemi Osinbajo represented by his Rule of Law advisor. Dr. Fatima Waziri-Azi, described the launch of the programme as laudable and timely. He expressed happiness that it is being implemented with the collaboration of the Federal Ministry of Education and other relevant agencies involved in the promotion of culture of lawfulness in Nigeria. WARIF trains young boys against sexual violence NNPC/Chevron National Arts competition for secondary schools… Africare, ExxonMobil, NBA expand school intervention programmes for… He express hope that the collaboration would further empower the nation’s education systems in developing young people’s ability in critically understanding the essential elements of accountability, equality fairness and respect for the rule of law, in adherence with domestic and international laws. “The UNODC-UNESCO ‘Global Citizenship Education for the Rule of Law’ emphasized the need for Education systems to uphold and promote respect for the rule of law, in adherence with international human rights and fundamental freedoms as well as nurture trust between learners and public institutions. This will in turn encourage and promote safety, dignity and respect for the rule of law amongst citizens…Indeed, including young people in building a country of integrity and strong institutions also allows them to positively shape the face of public institutions in Nigeria where non-violence and peaceful avenues of civic engagement is encouraged,” the Vice President said. The E4J Initiative is part of UNODC’s Global Programme for the implementation of the Doha Declaration which was launched following the 13th United Nations Congress on Crime Prevention and Criminal Justice with the support of the Government of the State of Qatar to help UNODC in assisting United Nations Member States in turning their ambitious commitments into reality. The overriding objective is to help educators teach the next generation basic values such as respect, integrity, fairness and empathy making them more resilient against crime, violent extremist ideologies, and drugs, to help them better understand problems that can undermine the rule of law and to encourage students to actively engage in their communities and future professions in the promotion of a culture of lawfulness. At the primary education level (6-12 years), E4J focuses on promoting and teaching values such as acceptance, integrity, respect and fairness. UNODC and its partners developed innovative materials and tools for children, animated series on the rule of law, a video game to tackle gender based violence. These tools will contribute to support learning on the 2030 Sustainable Development Goals, in particular Goals 4, 5, 10 and 16. At the secondary education level (children 13-18 years old), E4J focuses on providing practical and interactive educational materials such as board games and videos (hyperlinks) to promote the understanding of the basic concepts that lie at the core of UNODC’s mandate areas, including anticorruption, counter-terrorism, crime prevention and criminal justice, organized crime, cybercrime, firearms, and trafficking in persons and migrant smuggling. This is achieved through a focus on ownership, behaviour, rights and responsibilities, aimed at empowering secondary level students to identify, prevent and resolve moral, ethical or legal dilemmas. At the tertiary education (18+), E4J seeks to support tertiary level education institutions and academics in their efforts to transmit knowledge and create a deeper understanding of rule of law related issues. In order to do so, UNODC has already developed numerous university modules to assist scholars teaching on rule of law related issues such as crime prevention, organized crime, counter terrorism, trafficking in persons and smuggling of migrants or cybercrime. 2030 Sustainable Development GoalsEducation for Justice (E4J) InitiativeUNESCOUNODC Sam EFERARO Ebola spreads to Uganda Uganda hosts Inaugural African Hepatitis Summit NNPC/Chevron National Arts competition for secondary schools winners emerge Africare, ExxonMobil, NBA expand school intervention programmes for FCT schools UNICEF advocates new survey on out-of-school children – UNICEF Kenya introduces HPV vaccine into routine immunisation Adelusi-Adeluyi to address Executive Dialogue on Economic Growth in… Ghanaian president self-isolates after closed associate tests… World No Tobacco Day: WHO highlights huge scale of tobacco-related… Asthma strikes again! American retail pharmacy shops to stop Zantac sale Nigeria: Sanofi signs pact with May & Baker for local drug… UK approves first womb transplants Measle outbreak: WHO, Nigeria inauguirate Emergency Preparedness… Measles cases up 300 percent in 2019, WHO says Nigeria gears up for 2019 VivaTech Agony of teenage mothers dying to give Life Most of world’s population breathes dirty air· Nigeria gets low cost IVF centre Novo Nordisk partners UNICEF towards ending global childhood… Africa Health Times is an online health newspaper published by Healthways Communications Nigeria Limited, a communication company offering specialized Media services to pharmaceutical and other health-related companies. AHT seeks to provide relevant and up-to-date information on the African health care delivery systems, while also providing useful tips on healthy lifestyle for individuals. AGPMPN seeks investment, collaboration with Government Lagos moves to strengthen health workforce Final trial results confirm effectiveness of Ebola vaccine Integrity, panacea to exam malpractice – ICPC Chairman NAFDAC shuts 16 herbal medicine facilities FUNAAB to get diabetes centre UI hosts Federation of African Medical Students epic conference Doctor, is this cancer? Watch that fat belly © 2021 - Africa Health Times. All Rights Reserved.	cc/2021-04/en_middle_0086.json.gz/line1796949
__label__wiki	0.738442	0.738442	Shut Windows to save power, urges industry Barry Collins Read more October 7, 2009 Computer energy bills could be slashed by up to 40 per cent if Windows had its power management settings turned on by default, according to a leading environmentalist. “PCs consume 96% of their power in on-idle mode,” said Catriona McAlister, senior consultant for AEA Energy & Environment, speaking at an Intel discussion on energy efficient computing. “You could save 40% of annual energy consumption just by turning on power management on PCs and monitors.” McAlister, who has been involved in the implementation of the Energy Star label for ICT equipment, said it made sense for Windows power management features to be turned on at the point of manufacture, “as long as users had the option to turn it off.” Intel agreed it would make an enormous difference to power consumption. “Having it [power management] shipped ‘on’ makes sense. Otherwise, all across the city you’ve got computers on all night, just waiting in case there’s a patch to download,” said Gordon Graylish, vice president of Intel EMEA. However, other experts warned of unexpected side effects of over-zealous power management. “Tips like turning off PCs overnight are great, but if you can’t update your anti-virus overnight, you’re putting extra risk into your business,” said Karl Deacon, vice president and outsourcing chief technology officer at CapGemini. On a wider note, the panel agreed that industry-wide power consumption metrics were required to allow consumers and IT managers to make more informed choices when purchasing equipment. To that effect, a new version of the Energy Star label will be launched next year to cover both PCs and monitors, where only the top 25% most energy efficient equipment will qualify. Intel says this will help reduce the chaos of each manufacturer applying its own energy consumption benchmarks. “We absolutely do not want the confusion, it’s critical we do get this standardisation,” said Graylish. How to Make Two Columns in Google Docs Lee Stanton January 19, 2021 How to Hard Restart a Chromebook Best Notion Templates	cc/2021-04/en_middle_0086.json.gz/line1796962
__label__cc	0.521368	0.478632	100 Club, London Shawn James Support: Ralph Pelleymounter London - 100 Club 19:29 \| 19/02/21 Robert Jon & The Wreck Legendary Shack Shakers BUSTER SHUFFLE venue still continues to showcase some of the most exciting new music in London with recent shows from artists such as Blood Orange, The Fat White Family, Dean Blunt, Parquet Courts, Jake Bugg, Kindness, Joey Bada$$, Pulled Apart By Horses, The Smith Westerns, The Orwells, Radkey and A$AP Ferg across it’s programming of regular events and hosting of NME Awards Shows, Converse Gigs and other series. Please contact the venue directly for information W1D 1LL	cc/2021-04/en_middle_0086.json.gz/line1796963
__label__cc	0.532185	0.467815	Conflict with Indians As the pioneers moved west, they built cabins, claimed land for farms, and hunted animals and birds. The Indians felt angry and afraid. They believed the earth belonged to everyone and couldn’t be claimed by one person. They also believed in living simply and using resources carefully, only taking what they needed. The two groups were so different in their ways of living and thinking. They were bound to have conflict. The settlers gathered in fighting forces. Sometimes they would attack Indian villages, killing the Indians or burning their houses to the ground. The Indians were stealthier, usually attacking one lone farm or cabin. They also burned buildings to the ground, killing the inhabitants or kidnapping children, adopting them into the tribe. One woman defended her home from an Indian attack by burning a feather mattress in her fireplace. The Indians tried to slide down the chimney, but were sickened by the smoke. The woman killed them with an axe. Indians often scalped their victims as trophies of their bravery. They cut the skin and hair off the person’s head, drying it and hanging it from their belts. They sometimes shot flaming arrows at cabins, starting fires. When the settlers came out of the cabins, the Indians shot them. Settlers began building forts called stockades. The stockades had high walls and buildings. From this vantage point, men could shoot at the Indians. Question: Were the Indians and settlers ever friends? Answer: Yes, the two groups sometimes did become friends. Find out more about Indian and pioneer relations. Declan, Tobin. " Conflict with Indians - American History For Kids ." American History for Kids, Jan 2021. Web. 20 Jan 2021. < https://www.americanhistoryforkids.com/conflict-with-indians/ >. Tobin, Declan. (2021). Conflict with Indians - American History For Kids. American History for Kids. Retrieved from https://www.americanhistoryforkids.com/conflict-with-indians/	cc/2021-04/en_middle_0086.json.gz/line1796965
__label__wiki	0.649353	0.649353	Updated 22 June, 2014 - 11:52 ancient-origins 150,000-Year-Old Pipes Baffle Scientists in China: Out of Place in Time? By Tara MacIsaac , Epoch Times Oopart (out of place artifact) is a term applied to dozens of prehistoric objects found in various places around the world that seem to show a level of technological advancement incongruous with the times in which they were made. Ooparts often frustrate conventional scientists, delight adventurous investigators open to alternative theories, and spark debate. In a mysterious pyramid in China’s Qinghai Province near Mount Baigong are three caves filled with pipes leading to a nearby salt-water lake. There are also pipes under the lake bed and on the shore. The iron pipes range in size, with some smaller than a toothpick. The strangest part is that they may be about 150,000 years old. Dating done by the Beijing Institute of Geology determined these iron pipes were smelted about 150,000 years ago, if they were indeed made by humans, according to Brian Dunning of Skeptoid.com. And if they were made by humans, history as it is commonly viewed would have to be re-evaluated. The dating was done using thermoluminescence, a technique that determines how long ago crystalline mineral was exposed to sunlight or heated. Humans are only thought to have inhabited the region for the past 30,000 years. Even within the known history of the area, the only humans to inhabit the region were nomads whose lifestyle would not leave any such structures behind. The state-run news agency Xinhua in China reported on the pyramid, the pipes, and the research began by a team scientists sent to investigate in 2002. Though some have since tried to explain the pipes as a natural phenomenon, Yang Ji, a research fellow at the Chinese Academy of Social Sciences, told Xinhua the pyramid may have been built by intelligent beings. He did not dismiss the theory that ancient extraterrestrials may be responsible, saying this theory is “understandable and worth looking into … but scientific means must be employed to prove whether or not it is true.” Another theory is that it was built by prehistoric humans with techniques lost to humans of a later period. The pipes lead into a salty lake, though a twin lake nearby contains freshwater. The surrounding landscape is strewn with what Xinhua described as “strangely shaped stones.” Rocks protrude from the ground like broken pillars. The head of the publicity department at the local Delingha government told Xinhua the pipes were analyzed at a local smeltery and 8 percent of the material could not be identified. The rest was made up of ferric oxide, silicon dioxide, and calcium oxide. The silicon dioxide and calcium oxide are products of long interaction between the iron and surrounding sandstone, showing the ancient age of the pipes. Liu Shaolin, the engineer who did the analysis, told Xinhua: “This result has made the site even more mysterious.” “Nature is harsh here,” he said. “There are no residents let alone modern industry in the area, only a few migrant herdsmen to the north of the mountain.” To further add to the mystery, Zheng Jiandong, a geology research fellow from the China Earthquake Administration told state-run newspaper People’s Daily in 2007 that some of the pipes were found to be highly radioactive. Other Theories Jiandong said iron-rich magma may have risen from deep in the Earth, bringing the iron into fissures where it would solidify into tubes. Though he admitted, “There is indeed something mysterious about these pipes.” He cited the radioactivity as an example of the strange qualities of the pipes. Others have said iron sediments may have washed into the fissures, carried with water during floods. Though Xinhua and other publications in China have referred to a pyramid or even a mysterious pyramid in which the pipes were found, some have said it was a pyramid-shaped natural formation. Another theory is that the pipes are fossilized tree roots. Xinmin Weekly reported in 2003 that scientists found plant matter in an analysis of the pipes, and they also found what looked like tree rings. The article related the finding to a geological theory that in certain temperatures and under certain chemical conditions, tree roots can undergo diagenesis (transformation of soil into rock) and other processes that can produce iron formations. Reports on the tree-root explanation for the so-called Baigong pipes often lead back to this Xinmin Weekly article or lack citation. It’s unclear exactly how well-supported this theory is in relation to the Baigong pipes. An article published in the Journal of Sedimentary Research in 1993 describes fossilized tree roots in South Louisiana in the United States. Featured image: Baigong Cave, with photo of pipe in the bottom left. Source. The article " 150,000-Year-Old Pipes Baffle Scientists in China: Out of Place in Time? " was first published by Epoch Times oopa out-of-place artifact Baigong pipes Ancient-Origins This is the Ancient Origins team, and here is our mission: “To inspire open-minded learning about our past for the betterment of our future through the sharing of research, education, and knowledge”. At Ancient Origins we believe that one of... Read More meadg wrote on 20 February, 2015 - 14:28 Permalink As usual why let facts get in the way of a good “It’s Aliens Theory”. From what I’ve read here http://skeptoid.com/episodes/4181 they are fossilised trees!!! It quotes “The Chinese scientists eventually did come to the same conclusion, according to the Xinmin Weekly article. They used atomic emission spectroscopy to conduct a detailed chemical analysis of the rusty pipe fragments, and found them to contain organic plant matter. Under the microscope they found tree rings, consistently throughout the samples. Once they established that the Baigong Pipes were simply fossilized tree casts, they set about to discover how they got there.” jay galloway wrote on 12 February, 2015 - 01:25 Permalink Y'all obviously never watched the Flintstones. Neophytes...sheesh Aymeric wrote on 3 February, 2015 - 13:17 Permalink Other similar "artifacts" have been found in the US, those are natural features and mostly made of hematite (ironstone), sandstone (silicone dioxide) and calcite (calcium oxide). Nothing worth going all woop-woopart ! stipsburg wrote on 26 January, 2015 - 13:56 Permalink Hundreds and hundreds of 'strange' artifacts arise. Mainstream sciense pushes them under the carpet, ignores thm or gives some funny 'explanations'. I hope time will come when real scientists like Tesla, Shuaberger will lead the mankind in new discoveries which will not be hidden from us. Dr. Smallberries wrote on 26 December, 2014 - 19:10 Permalink It's just an RV hook-up for a huge spacecraft, so the "gods" could land and take on fresh water. Most of them are humanoid and need water. Nearly all pyramids were created as landing pads, to keep the "paeons" at a distance, and show off power as much as possible. Much of earth history is a tragic recollection of "us and them," sky and ground. But we are slaves no longer. (72 Comments) The Mysterious Dropa Stones – Fact or Fiction? The Dropa stones are said to be a set of 716 circular stone disks dating back 12,000 years on which tiny hieroglyphic-like markings can be found. Each disc is said to measure up to 1 foot in diameter... Read more about The Mysterious Dropa Stones – Fact or Fiction?	cc/2021-04/en_middle_0086.json.gz/line1796966
__label__wiki	0.951398	0.951398	Happy Birthday, YouTube! Now, Get Back to Work and Make Money Rick Aristotle Munarriz Happy Birthday, YouTube! Google's (GOOG) fast-growing YouTube turned 7 on Monday. The world's most popular video-sharing website has come a long way in its brief life. Many of its milestones and metrics are jaw-dropping. There are 72 hours of video uploaded to the website every minute. YouTube receives 800 million unique visitors a month, who consume 3 billion hours of clips. There are now tens of millions of channels, and subscriptions to the content channels have increased 50% over the past year. Despite all of YouTube's achievements, this is really only the beginning. For the sake of Google investors who have seen the search giant try to monetize its website more effectively without alienating users, let's go over a few of the things that can turn YouTube into a monster moneymaker for the world's most valuable Internet company. Time to Really Monetize the Masses Three years ago, I was invited to the YouTube Partners program. Since then, the number of partners that YouTube has accepted to its program -- where those uploading original videos that are viewed by reasonably sized audiences can enter into ad-sharing deals through Google -- has grown. YouTube has also expanded the program to let some nonpartners monetize some of their viral videos. I was one of the lucky ones -- an early arrival on YouTube with modest success as a content creator. Now YouTube needs to make it even easier for its tens of millions of channel creators to make money on the website, and there are plenty of ways to make that happen. Put out a tip jar: Google has tried to compete with eBay's (EBAY) PayPal as a transactional platform with Google Checkout, but it has a long way to go. One thing it could do is incorporate virtual tip jars on YouTube channels. Getting interested content creators to sign up for Google Checkout accounts and encouraging viewers to contribute would go a long way toward popularizing the platform. Kick things up Kickstarter style: Kickstarter.com is a fast-growing website that allows entrepreneurs and artists to raise money for projects. It's the poster child of "crowd funding" where visitors vote with their pocketbooks on what they want to see materialize and receive perks for financials participation. YouTube has launched its own funding efforts to nab proprietary content, but it needs to reverse the process and let viewers interact with compelling projects. Get more action from ads: Google rocks in paid search. It's a beast in sizing up text on website pages and serving up contextual ads that are relevant. It's harder to pull that off on an eye-candy platform. Google could be serving up better ads if it got to know its video content a little better. YouTube needs to encourage more descriptive text -- whether this is a matter of easier integration with its own Blogger, educating partners on the power of accurate words, or staffing a fleet of compensated reviewers for high-traffic clips. It's understandable why YouTube just doesn't flip the switch and let every channel owner generate click-based revenue. Gaming the system and the uploading of unauthorized content are big enough problems already. (The last thing that YouTube needs is to pursue monetization at the expense of the credibility of Google's ad platform.) However, YouTube can do a better job of working with cost-per-action ads where advertisers only pay if something is actually sold or a lead is genuinely created. In the end, it's about incentivizing content creators, but also engaging viewers in interactive ways. Follow Netflix Into Premium Video Subscriptions YouTube's success has translated perfectly into mobile, where viewers crave the short-form clips that the website provides. We're talking about 600 million playbacks a day on mobile devices! The problem with YouTube -- as a business -- is that it's serving up chunky media files to 800 million largely freeloading customers where putting up with ads isn't always enough. Netflix (NFLX) didn't begin streaming until a year after YouTube was born, yet it's up to 26 million global streaming accounts. Imagine what a successful premium streaming service could do for Google TV or its hairy relationships with hesitant movie studios and TV producers. YouTube can never lose the free side of the video-sharing site, but it needs to exploit its mobile magnitude before Netflix runs away with the market. It doesn't have to end there, of course. Google can take a page out of the original MP3.com playbook with the New Music Army program of incentivized promoters. It can arm video makers with even better authoring tools, and make the clips more engaging with polls and other embedded features. YouTube will get there, but let's hope that it's as impatient as most 7-year-olds and evolves quickly. Motley Fool contributor Rick Munarriz does not own shares in any of the stocks in this article, except for Netflix. The Motley Fool owns shares of Google and Netflix. Motley Fool newsletter services have recommended buying shares of Netflix, eBay, and Google. Get info on stocks mentioned in this article: Manage Your Portfolio internet video InternetVideo StreamingVideo	cc/2021-04/en_middle_0086.json.gz/line1796970
__label__cc	0.732977	0.267023	Search the APM website CHARTERED STANDARD PMO SIG pre-conference webinar: How to succeed at conferences and networking events Login to bookmark this Ever turned up at a conference and felt like you don’t know anyone else around? Ever had a networking lunch and not been sure how to break the ice with strangers? This webinar on Tuesday 3 October gave some insights on how to get the very most out of our (and other) conferences and events you might attend to make sure you get the most value from your time with us. Who should engage with this content? Firstly anyone who has booked onto this years’ PMO SIG conference on 19 October 2017, suitable for existing PMOs who are at a crossroads in their journey and struggling to define the path to bring new services and disciplines to their organisation. Additionally anyone who would like to gain more from networking and conference opportunities. Osian Evans is a P3M consultant with a passion for giving something back to his field of work – fostering collaboration, developing thought leadership and inspiring the next generation of project professionals. Currently a Management Consultant for Pcubed global portfolio, programme and change management consultancy. Over the past ten years he has managed and worked in various transport and infrastructure projects, programmes and portfolios. He attends various conferences throughout the course of a year, as it is the best way to keep up with the latest challenges and insights across industries - and is great for professional networking. A ndrew Honey is the Director of Solid Board, who started life as a qualified engineer then developed it with a business education, an MBA and 40 years of successful delivery across industry, commerce and government. A Lean Six Sigma Black Belt, embedding portfolio, programme, project management and change capability in an environment of uncertainty for the Higher Education sector. He is uniquely experienced in the application of solutions to the growing challenges of climate change, security of energy supply and skills transformation for a low carbon economy. Osian and Andrew have very kindly allowed their presented material to be made available for viewing. The slides have been listed on Slideshare and the webinar recording on YouTube are now available in our APM resources area and also below for reference. This webinar content is suitable for professionals with any level of experience. PMO SIG A creative community, APM Volunteer Achievement Awards 2020 nominee How human factors make all the difference in realising project benefits, APM Volunteer Achievement Awards 2020 nominee Lectures to share learning, APM Volunteer Achievement Awards 2020 nominee Running a PMO During COVID-19 webinar Delivering engagement in integration webinar Finding your PMO mojo following lockdown webinar Log in to post a comment, or create an account if you don't have one already. Follow us for the latest updates APM on Twitter APM on Facebook APM on LinkedIn APM on SlideShare APM on YouTube APM Research Competence Framework Privacy Policies and Cookies © 2020 Association for Project Management	cc/2021-04/en_middle_0086.json.gz/line1796973
__label__wiki	0.901928	0.901928	Showing results by narrator "John Rubinstein" in All Categories Relationships, Parenting & Personal Development Radio, Show or Performance Sort by Relevance Newest Arrivals Best-selling Title Length Avg. Customer Review Written by: Orson Scott Card Narrated by: Scott Brick, Gabrielle de Cuir, Amanda Karr, and others Xenocide is the third installment of the Ender series. On Lusitania, Ender found a world where humans and pequeninos and the Hive Queen could all live together; where three very different intelligent species could find common ground at last. Or so he thought. But Lusitania also harbors the descolada, a virus which kills all humans it infects, but which the pequeninos require in order to transform into adults. a let down compared to speaker for the dead. By Amazon Customer on 2018-11-13 Narrated by: Scott Brick, Gabrielle de Cuir, Amanda Karr, John Rubinstein, Stefan Rudnicki Series: The Enderverse, Book 12, Ender's Game, Book 3 4.5 out of 5 stars 94 ratings Price: CDN$ 48.29 An Alex Delaware Novel, Book 36 Written by: Jonathan Kellerman Narrated by: John Rubinstein LAPD homicide lieutenant Milo Sturgis is a master detective. He has a near-perfect solve rate, and he’s written his own rule book. Some of those successes - the toughest ones - have involved his best friend, the brilliant psychologist Alex Delaware. But Milo doesn’t call Alex in unless cases are "different". This murder warrants an immediate call. Milo’s independence has been compromised as never before, as the department pressures him to cater to the demands of a mogul: a hard-to-fathom, megarich young woman who is obsessed with reopening the coldest of cases. Series: Alex Delaware, Book 36 Pre-order: Free with 30-day Trial Children of the Mind Narrated by: Gabrielle de Cuir, John Rubinstein The planet Lusitania is home to three sentient species: a large colony of humans; the Pequeninos; and the Hive Queen, who was brought there by Ender Wiggin. Once again, the enemy (the Starways Congress) has gathered a fleet and is threatening to destroy Lusitania. Ender's oldest friend, Jane, an evolved computer intelligence, is trying to save the three sentient species of Lusitania, but the Starways Congress is destroying the computer world she lives in. Very annoying narration ruined excellent story By Lola Devi on 2019-06-04 Written by: Eugene Vodolazkin, Lisa C. Hayden - translator, Gabrielle de Cuir - director Narrated by: Stefan Rudnicki, Gabrielle de Cuir, John Rubinstein A man wakes up in a hospital bed, with no idea who he is or how he came to be there. The only information the doctor shares with his patient is his name: Innokenty Petrovich Platonov. As memories slowly resurface, Innokenty begins to build a vivid picture of his former life as a young man in Russia in the early 20th century, living through the turbulence of the Russian Revolution and its aftermath. But soon, only one question remains: How can he remember the start of the 20th century, when the pills by his bedside were made in 1999? The Wedding Guest An Alex Delaware Novel LAPD Lieutenant Milo Sturgis is a fine homicide detective, but when he needs to get into the mind of a killer, he leans on the expertise of his best friend, the brilliant psychologist Dr. Alex Delaware. While Sturgis has a knack for piecing together the details of a crime, Delaware can decipher the darkest intents driving the most vicious of perpetrators. And there’s no better place for the doctor’s analytical skills to shine than a rowdy hall full of young men and women intoxicated on life and lust...and suddenly faced with the specter of death. boreing!!!! By Sandra D. on 2020-05-12 The Museum of Desire Alex Delaware, Book 35 LAPD Lieutenant Milo Sturgis has solved a lot of murder cases. On many of them - the ones he calls "different" - he taps the brain of brilliant psychologist Dr. Alex Delaware. But neither Alex nor Milo are prepared for what they find on an early morning call to a deserted mansion in Bel Air. This one’s beyond different. This is predation, premeditation, and cruelty on a whole new level. Four people have been slaughtered and left displayed bizarrely and horrifically in a stretch limousine. Confounding the investigation, none of the victims seems to have any connection to any other. A Bit Overdone By Maureen on 2020-10-03 When the Bough Breaks Length: 3 hrs and 1 min Jonathan Kellerman has gained a loyal legion of fans with his best selling series of thrillers featuring child psychologist Alex Delaware. In When the Bough Breaks - the novel that started it all - Delaware is irresistably drawn to the case of a terrified child who is the only witness in a horrific double murder. Series: Alex Delaware (abridged), Book 1 Welcome to Hard Times Written by: E. L. Doctorow Hard Times is the name of a town in the barren hills of the Dakota Territory. To this town there comes one day one of the reckless sociopaths who wander the West to kill and rape and pillage. By the time he is through and has ridden off, Hard Times is a smoking ruin. The de facto mayor, Blue, takes in two survivors of the carnage - a boy, Jimmy, and a prostitute, Molly, who has suffered unspeakably - and makes them his provisional family. In the half-built skeleton of a monstrously vulgar mansion in one of L.A.'s toniest neighborhoods, a watchman stumbles on the bodies of a young couple - murdered in flagrante and left in a gruesome postmortem embrace. Though he's cracked some of the city's worst slayings, veteran homicide cop Milo Sturgis is still shocked at the grisly sight: a twisted crime that only Milo's killer instincts - and psychologist Alex Delaware's keen insights - can hope to solve. Written by: Sidney Sheldon The first entry in Leslie Stewart's diary read: "Dear Diary; This morning I met the man I am going to marry." It was simple, optimistic statement, without the slightest portent of the dramatic chain of events that was about to occur. The Best Laid Plans takes listeners inside two of America's most powerful and ruthless institutions: the world of politics with it's scandals, corruption, and cover-ups; and that of newspaper publishing, where it is not unusual to use the power of the press to destroy lives - or bring down heads of state - in pursuit of a story or to settle a score. Kind of disappointing 4.5 out of 5 stars 4 ratings Even having hundreds of closed cases to his credit can't keep LAPD police lieutenant Milo Sturgis from agonizing over the crimes that don't get solved - and the victims who go without justice. Victims like Katherine Hennepin, a young woman strangled and stabbed in her home. A single suspect with a solid alibi leads to a dead end - one even Alex Delaware's expert insight can't explain. The only thing to do is move on to the next murder case - because there's always a next one. The City of Angels has more than its share of psychopaths, and no one recognizes that more acutely than the brilliant psychologist and police consultant Dr. Alex Delaware. Despite that, Constance Sykes, a sophisticated, successful physician, hardly seems like someone Alex needs to fear. Then, at the behest of the court, he becomes embroiled in a bizarre child custody dispute initiated by Connie against her sister and begins to realize that there is much about the siblings he has failed to comprehend. Weird Women Classic Supernatural Fiction by Groundbreaking Female Writers: 1852-1923 Written by: Lisa Morton - editor, Leslie S. Klinger - editor Narrated by: Stefan Rudnicki, Gabrielle de Cuir, Justine Eyre, and others Weird Women, edited by award-winning anthologists Lisa Morton and Leslie S. Klinger, collects some of the finest tales of terror by authors as legendary as Louisa May Alcott, Frances Hodgson Burnett, and Charlotte Perkins Gilman, alongside works of writers who were the best sellers and critical favorites of their time - Marie Corelli, Ellen Glasgow, Charlotte Riddell - and lesser known authors who are deserving of contemporary recognition. Narrated by: Stefan Rudnicki, Gabrielle de Cuir, Justine Eyre, John Rubinstein, Paul Boehmer, Sile Bermingham Razor Girl Written by: Carl Hiaasen When Lane Coolman's car is bashed from behind on the road to the Florida Keys, what appears to be an ordinary accident is anything but (this is Hiaasen!). Behind the wheel of the other car is Merry Mansfield - the eponymous Razor Girl - and the crash scam is only the beginning of events that spiral crazily out of control while unleashing some of the wildest characters Hiaasen has ever set loose. belly laugh funny By Heather T on 2018-10-21 Length: 12 hrs The anonymous caller has an ominous tone and an unnerving message about something "real dead...buried in your marsh." The eco-volunteer on the other end of the phone thinks it's a prank, but when a young woman's body turns up in LA's Bird Marsh preserve no one's laughing. And when the bones of more victims surface, homicide Detective Milo Sturgis realizes the city's under siege to an insidious killer. Milo's first move: calling in psychologist Alex Delaware. great listen! By Thomas E Smyth on 2018-10-04 Must I Go Written by: Yiyun Li Narrated by: Jane Alexander, Alex McKenna, John Rubinstein Lilia Liska has shrewdly outlived three husbands, raised five children, and seen the arrival of 17 grandchildren. Now she has turned her keen attention to the diary of a long-forgotten man named Roland Bouley, with whom she once had a fleeting affair. Increasingly obsessed with Roland's intimate history, Lilia begins to annotate the diary with her own rather different version of events, revealing the surprising, long-held secrets of her past. At nearly 100 years old, Thalia Mars is a far cry from the patients that child psychologist Alex Delaware normally treats. But the charming, witty woman convinces Alex to meet with her in a suite at the Aventura, a luxury hotel with a checkered history. What Thalia wants from Alex are answers to unsettling questions - about guilt, patterns of criminal behavior, victim selection. When Alex asks the reason for her morbid fascination, Thalia promises to tell all during their next session. When he shows up the following morning, he is met with silence: Thalia is dead. A Cold Heart Length: 6 hrs "I’ve got a weird one, so naturally I thought of you,” says Milo Sturgis, summoning his friend Alex to the trendy gallery where a promising young artist has been brutally garroted on the night of her first major showing. What makes it “a weird one” is the lack of any obvious motive, and the luridly careful staging of the murder scene - which immediately suggests to Alex not an impulsive crime of passion...but the meticulous and taunting modus operandi of a serial killer. a good novel By Happy Listner on 2020-02-04 Debt of Honor Written by: Tom Clancy The end of history. The new world order. Fine phrases, but as Jack Ryan is about to discover, history isn't dead yet - and only the nature of the threat is new. In peacetime, a new enemy readies a strike not only at America's territory, but at the heart of her economy, and National Security Advisor Jack Ryan must prepare an untested president to meet the challenge. By Glazier guy on 2020-01-30 Series: Jack Ryan (publication order) (abridged), Book 6, Jack Ryan (chronological order) (abridged), Book 7 The Red Fairy Book The Andrew Lang Fairy Book Series Written by: Andrew Lang Narrated by: Claire Bloom, Paul Boehmer, Orson Scott Card, and others It is almost impossible to envision what childhood would be like without the enchanting world of fairyland. Three-headed trolls, horses that carry their masters up mountains of glass, giants and dwarfs, monsters and magicians, fairies and ogres - these are the companions who will thrill young boys and girls of all lands and all times, as Andrew Lang's phenomenally successful collections of stories have proved. Narrated by: Claire Bloom, Paul Boehmer, Orson Scott Card, Gabrielle de Cuir, Justine Eyre, Susan Hanfield, Kate Orsini, Emily Rankin, John Rubinstein, Stefan Rudnicki Series: Coloured Fairy Books Show 20 30 40 50 items per page Go back a page Go forward a page Your first free audiobook is waiting. Membership is CDN$ 14.95/month + applicable taxes, first 30 days free. Cancel anytime.	cc/2021-04/en_middle_0086.json.gz/line1796977
__label__wiki	0.788164	0.788164	On Consent: AISD Employees See Increased Wages A 1.5% increase will go to district employees By Richard Whittaker, Fri., May 26, 2017 The Austin Independent School District staff will get a 1.5% pay raise next year. That's less than employee union Education Austin initially asked for, but their hope is that a new incentive program will mean staff at the district's most demanding campuses will see extra pay in return for career development. AISD Superintendent Paul Cruz and Education Austin President Ken Zarifis signed a consultation agreement on May 22 approving the pay increase. Pending approval from the board of trustees, it will take effect July 1. As with all teaching employees, AISD staff have learned that pay raises are not a given. After a wage freeze during the 2011-12 school year, salaries bounced back with a 3% bump the following year – an improvement, but still not enough to match rising living costs in the Austin area. Next came a 1.5% bonus, paid for with a one-off state payment. After that expired came two years of 2% increases, followed by 3% in the 2015-16 school year, and finally a 4% bump last July. In that context, the 1.5% increase is definitely on the lower end, but the union knew it was walking into a difficult financial setting before negotiations started. The district was already facing a $30 million deficit, and that number was rising fast, even with no pay raise. The original budget projection was for no base pay increase, but EA pushed for 3%. With that clearly off the table, Zarifis said, "We tried to get a mix of 2 percent for classified [hourly workers] and 1.5 percent for everyone else," but the district didn't want to stratify in that way; they countered with 1%, but the union wouldn't go below 1.5%, and threatened to declare an impasse in negotiations. Had that happened, the matter would have gone to the AISD board. Rather than face that unpredictable body, the district settled on 1.5%. But that's just the baseline salary. Zarifis is hoping many teachers see a much bigger bump under the Professional Pathways for Teachers, a new system designed to encourage professional development. As pioneered in Baltimore by the American Federation of Teachers, EA's national parent body, staff will receive points for training, which translate into increases in baseline pay. This comes upon the expiration of the old REACH program – designed to incentivize teachers to stay at schools with high-needs populations, such as kids from economically disadvantaged households, or English-language learners. Under PPfT, staff at those campuses will see their points accelerated. As a result, Zarifis said, teachers who commit to ongoing training could see their baseline pay increase by thousands of dollars over their career, "and that never goes away." The consultation agreement also includes a slightly tougher pill to swallow, with health insurance taking effect at the end of the year. Currently, employees are offered three options: a free health savings account (HSA); a free preferred provider organization (PPO) plan; or a buy-up option, PPO Choice. Under the consultation agreement, the zero-dollar HSA remains, the free PPO goes, and there will be two buy-up options PPO Seton joins PPO Choice. Currently, 60% of AISD employees use the free PPO – to offset their buy-up cost, the district agreed to increase its contribution, and create structured tiered staff contributions, meaning janitors will pay less than senior administrators for the same care. The loss of the free PPO will be a blow to AISD, as its health care plan has always been one of its best recruiting tools. With high teaching costs, plus the burden of recapture, teacher base salaries have lagged as far as $5,000 behind comparable neighboring districts. However, Zarifis said he hopes the balance between the pay raise, PPfT opportunities, and above-average health care will keep AISD competitive. "It's a challenge to retain staff, but it's a challenge to retain staff in every district in this state," he said. In total, AISD staff costs rise $11 million next year, part of a $58 million predicted revenue shortfall. That's due less to the wage increase than to the $320 million the district will send to the state next year under the "Robin Hood" school finance recapture system. Whatever the cause, the district now faces a dip into savings to cover costs. Chief Financial Officer Nicole Conley's office forecasts that AISD will still have $180 million in the general fund balance at the end of fiscal year 2018. Overall, Zarifis said, "With what we're playing with, and a $58 million deficit, that we're able to pull out $11 million extra in compensation – I'm not happy with the result, but I'm proud of the effort." More Austin Independent School District COVID at AISD: Union Lodges Grievances as District Plays Hardball Education Austin files over 100 grievances on behalf of teachers denied accommodations for spring semester Clara Ence Morse, Dec. 25, 2020 Amid COVID-19 Spread, AISD Benchmarks Its Future District changes dozens of its performance measures Clara Ence Morse, Nov. 20, 2020 More by Richard Whittaker Bears Rebecca Fonté Joins aGLIFF as Artistic Director Festival rebranding as PRISM for new era Robert Lorenz Takes Aim at The Marksman Writer/director on why Liam Neeson is the new Clint Eastwood Austin Independent School District, Ken Zarifis, Paul Cruz, Robin Hood, Nicole Conley	cc/2021-04/en_middle_0086.json.gz/line1796979
__label__wiki	0.845941	0.845941	4 Performer Matches: Doug Hall, Jerry Jeff Walker, Oakley Hall ... [show more] 4 Performer Matches: [show less] Doug HallJerry Jeff WalkerOakley HallPreservation Hall Jazz Band 241-270 of 516 results, sorted by relevance \| sort by date The Party Circuit The Real Southwest Conference "...can expect $500-$3,500 a night, with party legends like Jerry Jeff Walker or the Fabulous Thunderbirds walking away with..." Nov. 29, 1996 Music Feature by Andy Langer 311 Story in Error "...Joe Valentine, Velma Marshall, Sue Arledge..." Oct. 25, 1996 Column "...the key elements that makes Safe such an enormously challenging film is that writer/director Todd Haynes leaves these critical..." Sept. 22, 1995 News Feature The Adventures of Sancho Panza Guitar Techs "...be anything - it could be some look Doyle [Bramhall] gave him, it could be some problem with the..." June 23, 1995 Music Feature Playback: Armadillo Tales A review of the best book on Austin’s 1970s music scene since The Improbable Rise of Redneck Rock "...impresario behind the Threadgill's restaurants and the titular concert hall, as a Texan amalgam of concert promotions legend Bill..." April 7, 2017 Music Column by Kevin Curtin HOF Hopefuls "...fascinated with the so-called “complete list” of Austin Music Hall of Fame inductees. But, there are some glaringly absent,..." March 13, 2017 Postmarks 35 Years of the Austin Music Awards Living in a dream "...“Don’t be intimidated,” challenges Kerr to the crowd. “We’re not.”..." March 3, 2017 Features Feature by Doug Freeman Playback: Chilling With ScoreMore Austin promoters ScoreMore tap San Antonio "...be key in its rebranding as Alamo City Music Hall. The connection between Backstage owner Sylvia Fernandez and ScoreMore..." Nov. 28, 2014 Music Column by Kevin Curtin Waltz Across Texas Is the Broken Spoke being edged off South Lamar? "...That was especially true in Texas, where dance halls were as much a part of city life as..." Aug. 2, 2013 Music Feature by Margaret Moser In an excerpt from Bobby Whitlock: A Rock 'n' Roll Autobiography, Delaney & Bonnie & Friends sow the seeds of Eric Clapton's Derek & the Dominos "...Ozium spray. After a while, we went down the hall and listened through the door while Delaney and Leon..." July 15, 2011 Music Feature by Bobby Whitlock Weighing in on the Live Music Task Force's recommendations to City Council and casting a ballot for the Rock & Roll Hall of Fame "...Music Foundation at Antone's for a march to City Hall today, 1pm. See "Music Deportment" for more. Revolutionary Ways..." Nov. 21, 2008 Music Column by Austin Powell Good events for good citizens, Oct. 23-30 "...Waggoner and Donna Howard, HD 50's Mark Strama and Jerry Mikus, and county Commissioner Gerald Daugherty. 7-8pm. St. Thomas..." Your good-citizen calendar for July 31-Aug. 7 "...more, see "Breast-Feeding Campaign Kicks Off.") 11am-1pm. Austin City Hall, 301 W. Second, 974-2220. Free. www.worldbreastfeedingweek.org/usa.htm. SATURDAY 02..." Aug. 1, 2008 News Feature Luckenbach! Compadres! Reviewed "...of outlaw and gonzo country, a reputation cemented with Jerry Jeff Walker's classic 1973 live recording at the town's..." Sept. 7, 2007 Music Feature by Doug Freeman Thank You, Central Time Zone: A Preview of the 2007 NFL Draft "...a squad pays the kid). Personally, I think we shall have one of the most drama-packed drafts in recent..." April 26, 2007 Sports Post by Timothy Braun On the Lege Austin Rep. Elliott Naishtat is leading charges to protect both seniors and children this session "...Web site www.fixedearth.com. Run by former high school teacher Marshall Hall, it claims that many scientific theories of the..." Feb. 23, 2007 News Column by Amy Smith SXSW 04 encore: Saturday showcases and more "...Greg Beets: N.E.R.D., Austin Music Hall, Saturday..." March 26, 2004 Music Feature Our readers talk back. "...an agenda, but few have a workable plan ["City Hall's Bumpy Road," May 23]. We fail to realize that..." May 30, 2003 Column "...organisms, on Wednesday, Oct. 10, 7-9pm, at Bass Lecture Hall (UT campus, Sid Richardson Hall, LBJ School of Public..." Oct. 5, 2001 News Feature by Lauri Apple Dancing About Architecture Christmastime comes to Austin. "...the Bazaar runs December 9-24 at the Austin Music Hall. This week's entertainment schedule includes: Saturday Champ Hood &..." Dec. 8, 2000 Music Column by Ken Lieck SXSW Showcase Picks: Friday "...Christopher Gray 8pm: Jim Lauderdale, Austin Music Hall..." A World in Which All Worlds Fit "...hippies -- who descended in droves upon the old-time dancehall on Austin's south side...." Dec. 4, 1998 Music Feature by Jay Hardwig Stage Frights "...appetite for seasonal entertainment is damn near insatiable. At Halloween, we crave the macabre, and we seek it in..." Oct. 30, 1998 Arts Feature "...the NARAS's superstar Tejano Extravaganza at the Austin Music Hall, or head to the other side of town and..." "...Miss Lavelle White, Sarah Brown Trio. Saturday 12: Doyle Bramhall II, Toni Price. Sunday 13: Guy Forsyth, Hen House,..." July 11, 1997 Music Feature Hot Movie Previews Sneaking Into Summer "...with Rene Russo, Robbie Coltrane, Alan Cumming, Irma P. Hall...." May 23, 1997 Screens Feature by Marjorie Baumgarten The Last Don Bob Bullock: The Crusty Boss of Texas Politics "...both ears during conversations. His breathing has the rapid, shallow rhythm that characterizes emphysema patients. But like many lifetime..." Jan. 31, 1997 News Feature by Robert Bryce Do the Chili Mac "...to Nashville) in came one of his artists, Michael Hall, who was spotted at his old stomping grounds, the..." Dec. 13, 1996 Music Column "...Austin Music Hall, November 27..." Dec. 6, 1996 Music Feature Record Reviews: Reissues "...Hundred Year Hall (Grateful Dead/Arista)..." Dec. 8, 1995 Music Review « 1 ‹ BACK 4 5 6 7 8 9 10 11 12 13 NEXT › 18 »	cc/2021-04/en_middle_0086.json.gz/line1796980
__label__wiki	0.630109	0.630109	Downer EDI flags revenue uncertainty (19) November 7, 2013 Downer EDI says a reduction in major capital works by miners will affect the company’s bottom line, with uncertainty surrounding revenue for the 2014 financial year. Port Hedland breaks iron ore export records, again (0) November 7, 2013 Port Hedland has posted another record month of iron exports to China, with 25.2 million tonnes of the steel making ingredient that sailed away easily beating the previous record highs ... Linc Energy dumps coal gasification project (0) November 7, 2013 Linc Energy will close its Chinchilla underground coal gasification facility after accusing the Queensland government of siding with the rival CSG sector. Caterpillar workers from Burnie to work in Thailand (0) November 7, 2013 Some of the workers from the Caterpillar plant in Burnie will work at the factory in Thailand that took jobs from their own plant. Waratah Coal’s rehabilitation efforts fail ‘environmental duty’ (0) November 7, 2013 Clive Palmer’s Waratah Coal has been slapped with an Environmental Protection Order over failures to meet its environmental duty to rehabilitate almost 300 exploration holes drilled on private properties. Stable iron ore price a boon for miners (3) November 7, 2013 Australia’s iron ore miners have added over $65 billion to their value over the last financial year as the crash in iron prices failed to materialise. Ausdrill halves profit forecast (139) November 7, 2013 Downgrading its profit forecasts by half, mining service company Ausdrill is the latest contractor to be hit by the weaker mining market. Rio Tinto’s rough diamonds go under the hammer (0) November 7, 2013 Some of Rio Tinto’s largest rough diamonds from three of its operating diamond mines have gone under the hammer. 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Glencore takes out Australian Mines Rescue Competition (0) November 6, 2013 Glencore’s Oaky Creek North mine has won the Australian Mines Rescue Competition at Cook Colliery. Pay relief for Gujarat mine workers (0) November 6, 2013 Gujarat workers are finally set to receive wages owed to them as the company’s new managers announce plans to pour up to $350 million into the business to keep it ... Industry group says carbon tax cut will not mean big savings (0) November 6, 2013 AIG has warned that the Government’s repeal of the carbon tax will not immediately result in major savings for consumers. Ausdrill calls timeout, profit downgrade expected (0) November 6, 2013 Mining services company Ausdrill is warning challenging market conditions will impact its bottom line. Caterpillar to cut 200 jobs in Burnie (0) November 5, 2013 Mining equipment manufacturer Caterpillar will cut 200 jobs from its Burnie plant in Tasmania’s north-west. Queensland gas boom fires up job numbers (0) November 5, 2013 A new report by Energy Skills Queensland found the gas sector will employ more than 14,100 workers when it peaks in 2024, double the number predicted previously. Australia will be the biggest loser as China slows down: Business Monitor (0) November 5, 2013 New research has found Australia’s resources sector is set to suffer the spill over effects of a sharp investment slowdown. Peabody workers march in protest (0) November 5, 2013 Around 100 workers from Peabody’s Helensburgh mine marched through the small township to the company’s office yesterday before voting on a new pay deal. 200 contractors cut from Anglo’s Dawson coal mine (0) November 5, 2013 Anglo American will cut 200 contractor jobs at its Dawson coal mine in Queensland as the company moves to reduce operating costs. 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Helensburgh miners urged to end pay deal dispute (3) November 4, 2013 With Helensburgh mine workers set to vote on a new enterprise agreement today, employees have been sent a letter from Peabody’s chief operations officer urging them to vote up the ... Kevin’s Corner secures federal approval (0) November 4, 2013 The Federal Government has signed off on GVK Hancock’s Kevin’s Corner project in Queensland, making it one of the country’s largest coal mines. And the winner is… Mining (0) November 1, 2013 More than 300 people turned out for the tenth annual Australian Mining Prospect Awards on Thursday night. Earthquake traps nine miners in BHP mine (0) November 1, 2013 Nine BHP Billiton miners have been rescued after an earthquake rocked an underground nickel mine in Western Australia. Shree Minerals open Tasmanian iron ore mine (0) November 1, 2013 Shree Minerals have officially opened the Nelson Bay River mine after a protracted process which saw court injunctions and protests levelled against the company. WA moves to streamline environmental approvals (0) October 31, 2013 Western Australia has joined its eastern counterparts to become the latest state government to announce it is reforming its mining approvals process. 10th annual Australian Mining Prospect Awards: mining’s reason to celebrate (0) October 31, 2013 With the judges decisions handed down all there is left to do is chill the beer and champas for Australian Mining’s 10th annual Prospect Awards, being held at the Ivy ... Boral worker blames local council for mine closure (0) October 31, 2013 Recently redundant Boral employee and local Wingecarribee councillor Graham McLaughlin has blamed a lack of council support for the closure of Boral’s Medway mine. 300 coal jobs hang on the approval of Acland mine expansion: New Hope (0) October 31, 2013 305 Queensland coal jobs hang in the balance as approval for the expansion of New Hope’s New Acland coal mine approaches decision day. Fortescue looks to refinance (0) October 31, 2013 In a bid to reduce its interest rate, Fortescue Metals Group has announced it is looking to amend and re-price its $US5 billion senior secured credit facility. Dark matter searched for in underground mine experiments (0) October 31, 2013 After months of experiments hunting for dark matter in a US former gold mine, scientists have finally released results. Downer donates $50k a year to the Smith Family (0) October 31, 2013 Downer EDI will donate $150,000 over three years to the Smith Family to help disadvantaged Australian kids access education and learning programs. Sandvik cuts NSW manufacturing jobs (0) October 30, 2013 Mining equipment manufacturer Sandvik will cut 37 jobs from its New South Wales operations as it battles weaker demand. Australia should strive to be the world’s top uranium producer: AUA (0) October 30, 2013 The Australian Uranium Association has said it’s about time Australia aimed to be the world’s top uranium producer, pointing to a raft of policy changes required to meet the target. ... Northern Star uncovers coal in the Pilbara (0) October 30, 2013 Northern Star Resources has struck coal while looking for gold in Western Australia’s Pilbara region. 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PNG seeks legal advice over seabed mining dispute (0) October 29, 2013 Papua New Guinea’s Government is seeking legal advice after the deadline passes for it to pay back seabed miner Nautilus Minerals. Gujarat workers asked to take leave without pay, chairman steps down (0) October 28, 2013 On the same day Gujarat NRE executive chairman Arun Jagatramka stepped down, the company has asked workers to take unpaid leave, despite not paying its miners properly for over a ... Howes criticises NSW and Victoria on CSG (0) October 28, 2013 The Australian Workers Union’s Paul Howes criticised both sides of politics and argued that Labor should embrace CSG extraction at a conference last Friday. Voluntary redundancies on offer at Cobar gold mine (0) October 28, 2013 NewGold is looking to cut production costs, offering 45 voluntary redundancies at its Peak Gold Mines in Cobar, New South Wales. Queensland donga business shuts on the back of poor industry demand (0) October 28, 2013 Nomad Building Solutions has placed its Queensland mining village business into care and maintenance as the company moves to cut costs. WA Government throws support behind fracking (0) October 28, 2013 Western Australia’s government is throwing its full weight behind the development of fracking techniques in the state to unlock billions of dollars worth of shale gas. Mining strategy for Dubbo as 1600 new jobs expected (0) October 28, 2013 The Dubbo City Mining Growth Strategy has received a leg-up from the state government, with $80,000 worth of funding directed to the project. Rio to sell majority stake of Clermont coal mine (0) October 28, 2013 Rio has agreed to sell off more than 50 per cent of its interest in Clermont to GlencoreXstrata for more than $1 billion. Bulldozer stuck on stockpile, operator rescued (0) October 25, 2013 An operator found himself trapped this morning when his bulldozer became partially engulfed in a live coal stockpile at Isaac Plains mine near Moranbah in central Queensland. Bushfire threatens FMG’s Cloudbreak mining camp, workers evacuated (0) October 25, 2013 Fortescue Metals Group’s Cloudbreak mining camp has been evacuated overnight as a bushfire burns threateningly close to the site. BHP and contractor slapped with fine over worker death (0) October 25, 2013 BHP Billiton Iron Ore and sub-contractor HWE Newman Services have been fined over $230000 for a fatal accident in Western Australia. Dan the watermelon shows the devastating effect falling objects can have (0) October 25, 2013 A graphic safety video released by Bechtel aims to teach workers how important it is to secure tools while working at heights, showing the horrific injuries that can occur by ... Centennial slashes 120 NSW mining jobs (0) October 25, 2013 Centennial Coal is cutting 120 jobs across its New South Wales operations. More needs to be done to protect NSW mining: Galilee (0) October 25, 2013 An industry survey of the top 26 mining companies in NSW has found they contributed around $12.8 billion on wages, goods and services last financial year but the NSW minerals ... Science should be at the centre of mining debates: Macfarlane (0) October 25, 2013 The Federal Minister for industry Ian Macfarlane says he finds it ironic that communities which were founded on the mining industry are now ‘hot-beds of resistance’, saying some of the ... FMG Christmas Creek miner loses leg (0) October 25, 2013 A truck driver has had his left leg amputated following an accident on Fortescue Metals Group’s Christmas Creek mine on Monday night. Mining downturn hurts Pacific Brands’ sales (0) October 25, 2013 Pacific Brands’ CEO John Pollaers told the company’s AGM that workwear sales have been hit by the slowdown in the resources sector. Greenland approves uranium mining (0) October 25, 2013 Greenland has approved uranium mining in the country after an extremely tight vote. QLD grants 1400 exploration permits in a week (0) October 25, 2013 The Queensland government has approved 1400 exploration permits in seven days as it attempts to bolster the state’s mining sector. Government releases draft legislation repealing the mining tax (0) October 24, 2013 The Federal Government has today released draft legislation set to repeal the Minerals Resource Rent Tax (MRRT). Boral puts Berrima Colliery into care and maintenance, 40 jobs cut (0) October 24, 2013 Almost 40 jobs will be cut as production is halted at Boral’s Berrima Colliery this week. Gujarat miners get ‘one off’ pay relief (0) October 24, 2013 Workers have had some relief in the continuing Gujarat pay issues, as the company organises a ‘one off’ payment. Ok Tedi immunity gone, with implications beyond BHP (0) October 24, 2013 Remote Mount Fubilan, near the source of Papua New Guinea’s Tedi River, is once again the site of global controversy surrounding the Ok Tedi copper gold mine. Fortescue Metals’ safety record under the spotlight (0) October 23, 2013 A second serious accident in three months at Fortescue Metals Group’s Christmas Creek mine has sparked concern within the mining industry. 800 Rio jobs to go as it outsources to IBM (0) October 23, 2013 Rio Tinto is expected to cut around 800 jobs globally after it signed a $100 million back-office outsourcing deal with US technology giant IBM. KBL’s Sorby Hills gains EPA approval (0) October 23, 2013 KBL Mining has secured approval from the Western Australian Environmental Protection Authority for its Sorby Hills project. Emeco appoints new CEO (0) October 23, 2013 Emeco has appointed Ken Lewsey and its new managing director and CEO. Bradken’s sales drop 10 per cent, warns more job losses to come (0) October 23, 2013 Mining services company Bradken is warning more job cuts are on the horizon as the company struggles deal with the mining downturn. QCG on track to produce first LNG in 2014 (0) October 23, 2013 The start-up of QCG’s LNG plant is one step closer after the last piece of gas pipelined needed to transport CSG has been laid in Queensland. RCR Tomlinson win $125m in mining contracts (0) October 23, 2013 RCR Tomlinson have been awarded three major mining contracts totalling around $125 million. Mine worker seriously injured at Fortescue’s Christmas Creek (0) October 23, 2013 A Pilbara mine worker has been seriously injured when two haul trucks collided at Fortescue Metals Group’s Christmas Creek mine. Federal approval delayed for $15b Arrow LNG project (0) October 23, 2013 Federal approval for Arrow Energy’s $15 billion Curtis Island LNG plant has been delayed as Federal Environment Minister Greg Hunt takes more time assess the potential impacts of the project. ... BHP boosts iron ore output, stabilises coal (0) October 22, 2013 BHP Billiton has seen iron ore output surge in the third quarter, lifting 23 per cent to 49 million tonnes compared to the same time last year. Gujarat miners walk off the job (0) October 22, 2013 Workers who had opted to stay on at two Gujarat-owned mines in the Illawarra despite not being paid for over four weeks announced they would strike if the money did ... Gold Fields cuts 60 mining jobs (0) October 22, 2013 Gold Fields has cut 60 workers from its newly acquired Lawlers operations, and a forthcoming operational review of the company’s newly acquired Yilgarn South mines has got employees worried more ... Santos deny claims contractors used sacred site as toilet (0) October 22, 2013 Santos has hit back at claims it used a scared Indigenous site as a rubbish dump, stating there is no evidence to support the claim, despite local Indigenous groups saying ... Dust devil sweeps through Roy Hill mine site (0) October 22, 2013 Workers at Roy Hill mine in the Pilbara were treated to a spectacular site at the weekend as a dust devil swept through the mine’s construction site. Dozer collides with light vehicle on BHP’s Mt Arthur coal mine (0) October 22, 2013 Workers were lucky to escape serious injury when dozer and a light vehicle collided at BHP Billiton’s Mt Arthur coal mine, in the Hunter Valley on Friday. Locked-out Peabody workers set up camp outside mine site (0) October 22, 2013 Locked-out workers from Peabody’s Helensburgh Metropolitan Colliery have set up a camp outside the mine’s entrance in protest of actions taken by the company to idle the mine for seven ... Anglo American starts tunnel boring at Grosvenor coal mine (0) October 22, 2013 Anglo American has started running its innovative tunnel boring machine at the Grosvenor coal mine in Moranbah. The current state of copper: Too soon for surplus? (0) October 22, 2013 The current notion that copper is coming back to surplus is being undermined, as French bank Natixis says Chinese stocks tell a different story. Gold downturn leads to higher crime rates (0) October 21, 2013 Western Australia’s Gold Stealing Detection Unit says the recent downturn in the resources sector has led to an increase in the theft of mining equipment. Founder returns to ownership at Mining Equipment Maintenance (0) October 21, 2013 Mining Equipment Maintenance is looking to the future, after its founding member, Paul Waardyk, has returned to ownership. Peabody’s productivity gains ease the pain (0) October 21, 2013 The search for productivity gains within Peabody Energy’s business is starting to pay, with the miner announcing it has improved production unit costs by 18 per cent since 2012. Port Kembla coal terminal workers to share in $2.5m after court win (0) October 21, 2013 Seventy-eight people who worked at the Port Kembla Coal Terminal between 1990 and 2005 will receive an average of $30,000 worth of superannuation payments each after a hearing in the ... Peabody locks out mine workers again (0) October 21, 2013 Peabody Energy has locked workers out of Helensburgh Metropolitan Colliery again as the dispute around a new enterprise agreement continues. NuCoal to sue Macdonald and the NSW government (0) October 21, 2013 NuCoal Resources is gearing up to launch legal action against former New South Wales mining minister Ian Macdonald and the state government. CSG company accused of dumping rubbish on sacred Indigenous sites (0) October 21, 2013 A native title group have protested outside a Santos shopfront after claims contractors working on the GLNG pipeline destroyed a cultural heritage site by using it as a rubbish dump. ... Aussie mining office attacked in Kyrgyzstan (0) October 21, 2013 Around 200 Kyrgyzstan nationalists have attacked Australian miner Manas Resources’ subsidiary’s local office. BHP provides $10m for Australian Indigenous scholarships (0) October 21, 2013 BHP Billiton has provided an additional $10 million to the Australian Indigenous Education Fund for secondary and tertiary scholarships for Indigenous students. Chinese women banned from studying mining degrees (0) October 21, 2013 Activists in China are challenging long-standing rules which ban women from studying mining degrees because “mining work is unsuitable for women”. Gold will only go up: Hegarty (0) October 18, 2013 Gold only has one way to go, and that’s in a “north easterly” direction, former Rio Tinto executive Owen Hegarty says. Removing blasting risks (6) October 18, 2013 A contractor’s ANFO hopper innovation is taking some of the risk out of mine development. Miners tell the story of their industry (0) October 18, 2013 The story of Australia’s mining sector has been penned, with the release of The Miners book. Newcrest’s gold output drops quarter-on-quarter (0) October 18, 2013 Gold miner Newcrest Mining has recorded back-to-back quarters of declining gold and copper production. Hedweld triumphs at NSW Premier’s Export Awards (0) October 18, 2013 The Hunter region’s Hedweld Engineering has won the NSW Premier’s Export Award in the energy and minerals sector, its third consecutive year of success at the awards. Explosives plant on track (0) October 18, 2013 The development of Yara International’s ammonium nitrate plant on the Burrup Peninsula is running to plan. Grange sees production boost, remedial works ahead of schedule (0) October 18, 2013 Magnetite producer Grange Resources’ North Pit mine redevelopment is running ahead of schedule, following a rock slide in July 2012. Outotec looks to cut 500 jobs (0) October 18, 2013 Outotec has announced that it will cut 500 jobs globally as it seeks to slash $71 million in costs. Corrimal Cokeworks to close after 100 years of production (0) October 17, 2013 After producing coke for more than 100 years, Corrimal Cokeworks has announced plans to close the operation next April. Bush fire threatens GlencoreXstrata’s Mangoola coal mine (0) October 17, 2013 A bushfire is raging out of control this afternoon near GlencoreXstrata’s Mangoola coal mine. NSW joins Qld, streamlines mining approvals (0) October 17, 2013 Following Queensland’s example earlier this week, the New South Wales Government is moving to streamline its approvals processes for the resources sector. Coal explorer in talks with Aurizon as mine development ramps up (0) October 17, 2013 Queensland coal explorer International Coal has announced it is in discussions with Aurizon over a rail access deal for its Consuelo project in the Bowen Basin. Stacker gantry installed at WICET stockyard (0) October 17, 2013 Wiggins Island Coal Expert Terminal is progressing closer to completion with the first stacker gantry lifted into place at the coal stockyard. Peabody’s dusty mine angers locals (0) October 17, 2013 Mudgee District Environment Group has accused Peabody Energy’s Wilpinjong Coal mine of disregarding its Environmental Pollution Licence twice last week, resulting in clouds of coal dust blowing through the town ... Jindal takes over Gujarat but still no relief for unpaid workers (0) October 17, 2013 Gujarat NRE shareholders have voted in favour of a takeover deal by Jindal Steel, but the exact date workers can expect to be paid four weeks’ worth of wages is ... Dairy company’s open cut coal mine given the go ahead (0) October 17, 2013 Fonterra, one of the world’s largest dairy companies, has been approved to start work on its Mangatangi open cut coal mine in New Zealand. Abbott’s one-stop approvals shop opening soon (0) October 17, 2013 Tony Abbott’s pre-election promise of a one-stop mining approvals shop is inching closer to being realised with the states close to a deal set to hasten the process. Miner loves grader so much he get grader tattoo (0) October 17, 2013 A man who has spent close to 25 years working on graders has clarified his feelings on the machine with a large grader tattoo. Where the mining jobs are: Hays Quarterly Hotspots (0) October 16, 2013 Mining engineers, senior metallurgists and HV electricians are just three of the roles mining companies are looking to fill as the preference for people with experience impacts hiring decisions, says ... Cripps defends Queensland mine safety review (0) October 16, 2013 Queensland Mines Minister Andrew Cripps has defended his review of the state’s mine safety regulations, dismissing claims by the CFMEU the reforms will lead to decreased safety. Gujarat shareholders to vote on takeover deal (0) October 16, 2013 The fate of embattled coal miner Gujarat NRE is set to be decided today, with shareholders voting at 2pm on whether to allow Jindal Steel and Power to become the ... Rio sees increasing tonnages in third quarter (0) October 16, 2013 Rio Tinto has lifted production results in the third quarter, stating that productivity improvements are now being realised. SEW Eurodrive wins Rio Tinto iron ore contract (0) October 16, 2013 SEW-Eurodrive has won a multi-million dollar contract to provide Rio Tinto’s Nammuldi iron ore mine with six belt conveyor drives. Roof collapse at Dendrobium Mine (0) October 15, 2013 Investigations are underway after a roof collapse at Illawarra Coal’s Dendrobium Mine in Mount Kembla yesterday. Rio’s Kestrel South mine officially open for business (0) October 15, 2013 Rio Tinto’s Kestrel South coal mine extension, located in central Queensland, has today been officially opened. Injured miner sues Xstrata for $2million (0) October 15, 2013 A miner is suing Xstrata Coal for almost $2 million, claiming he injured his back when working in muddy conditions. Andrew ‘Twiggy’ Forrest’s class act, donates $65m to WA universities (0) October 15, 2013 Mining mogul Andrew ‘Twiggy’ Forrest has made Australian history, making one of the biggest single philanthropic donations. Gujarat sends workers ‘useless’ payslips (0) October 15, 2013 Despite having not received payments for nearly four weeks, workers at Gujarat NRE have been sent payslips which show wages, taxes, superannuation and union fees have all been paid. Helensburgh mine workers vote to limit coal production (0) October 15, 2013 The workforce at Peabody’s Helensburgh Metropolitan Colliery have voted in favour of taking further industrial action after the company locked them out of the mine for three days. Treaty gives governments 15 years to end all mercury mining (0) October 15, 2013 Delegates from 140 nations and territories have signed the United Nations Minamata Convention on Mercury with the international treaty set to take effect in 90 days. QLD streamlines exploration approvals (7) October 14, 2013 The Queensland Government has today announced an overhaul of the coal and minerals exploration approvals process, billed to halve exploration permit wait times. Chinese government to shut 2000 coal mines in two years (0) October 14, 2013 China now accounts for 47 per cent of global coal consumption but as the country’s demand continues to climb it is now moving to clean up its domestic coal industry. Bechtel supports Curtis Island RFS (0) October 14, 2013 The Rural Fire Brigade on Curtis Island has received a $15,000 boost from Bechtel, with the donation set to better equip its volunteer firefighters. Copper find could see Mt Gordon reopened (0) October 14, 2013 A new copper find at Aditya Birla’s Mount Gordon mine near Mount Isa in Queensland is being reviewed by ANZ Bank, fuelling speculation about the mine’s future. Glencore to open Ulan mines to locals (0) October 14, 2013 GlencoreXstrata will open the gates of its Ulan Coal mines to locals on November 9 as part of a community day aimed at showcasing both its open cut and underground ... Peabody locks workers out of mine (0) October 14, 2013 More than 200 workers at Peabody’s Helensburgh Metropolitan Colliery have been locked out of the mine for 72 hours as the dispute around a new enterprise agreement continues. Chevron pulls intimate quiz (0) October 14, 2013 A probing Chevron recruitment questionnaire which asks prospective job seekers, amongst other things, about their reproductive history has now been withdrawn. Thousands march in protest at Romanian gold mine (0) October 14, 2013 Thousands of people have reportedly flooded the streets in Bucharest to protest Europe’s largest planned gold mine. Tassie’s Greens say they support mining, sometimes (0) October 11, 2013 The Tasmanian Greens party says it supports mining, depending on the project. Unsafe mine rumours not true: CFMEU (0) October 11, 2013 Rumours that operations at Gujarat NRE’s two coal mines ceased were quickly stamped out yesterday by both the company and the CFMEU. Sirius’ Nova-Bollinger on track to catch nickel revival wave (0) October 11, 2013 Sirius Resources’ Definitive Feasibility Study for its $AU471 million Nova-Bollinger nickel mine, in Western Australia, is on track for a go-ahead decision expected in June. GlencoreXstrata refuse to meet with Collinsville locals (1) October 11, 2013 Locals say it was an opportunity for GlencoreXstrata to present their side of the argument, but the multi-national miner refused to attend a community member meeting in Collinsville this week. ... FLIR launches new Ex-Series thermal imagers (0) October 11, 2013 FLIR has launched its new thermal imaging cameras, the FLIR Ex-Series. UGL fires Engineering CEO after less than a month (0) October 11, 2013 UGL have announced that newly appointed UGL Engineering CEO Russell Waugh will step down from the role, less than a month after being appointed. No mining camp for Singleton: Application denied (0) October 11, 2013 A proposed mining camp development slated for the Hunter Valley town of Singleton was last night rejected. Aurizon to cut 50 jobs in Queensland (0) October 11, 2013 Aurizon has announced it will cut 49 jobs from its Redbank and Ipswich workshops in Queensland. Mining is critical for everyone on the planet, Cutifani says (0) October 11, 2013 As Anglo American CEO Mark Cutifani becomes the chair of the ICMM Council he reiterates the importance of mining. Man rescued from Diamond Creek mine shaft (0) October 10, 2013 A man has been freed after being trapped in a Diamond Creek mine shaft for four and a half hours on Wednesday afternoon. Linc’s Blair Athol relaunch to create 250 local coal jobs (0) October 10, 2013 Linc Energy will release plans detailing the reopening of the Blair Athol coal mine within the next four weeks. Jindal takeover bid still unclear as Gujarat saga drags on (0) October 10, 2013 The CFMEU has met with Jindal Steel and Power, the potential new owners of Gujarat NRE, however it is still unclear whether a share deal meeting next week will see ... Chevron quizzes ‘reproductive outcomes’ (0) October 10, 2013 A job application questionnaire has sparked outrage amongst the mining community. Aquarius female employee found dead in underground mine (0) October 10, 2013 A female has been found dead at Aquarius Platinum’s Kroondal underground mine in South Africa. Public hearings start over Drayton South mine expansion (0) October 10, 2013 The NSW Planning Assessment Commission will hear from at least 27 stakeholders today in public hearings over the proposed expansion of Anglo American’s Drayton South mine. WDS wins $50m of resources contracts (0) October 10, 2013 WDS Limited has won more than $50 million worth of contracts for its Energy Division, after Santos and Vale extended existing agreements. Whitehaven awards Leighton rail contract (0) October 10, 2013 Whitehaven Coal has awarded Leighton Contractors its infrastructure construction contract. Locked-out Yallourn employees return to work (0) October 10, 2013 Seventy-five workers who were locked out of Yallourn Power Station for nearly 100 days without pay have returned to work after voting on an in-principle wage and conditions agreement. Is your time of the month Chevron’s business? (0) October 9, 2013 Gas company Chevron has been criticised for posing intrusive questions to job seekers, asking if they are pregnant, had an abortion, ever contracted an STD or whether they take birth ... LNG to drive ‘super growth’ in Australia (0) October 9, 2013 Australia’s growing liquefied natural gas sector will provide the biggest boost to Australia’s economy over the next 20 years, advisory firm Deloitte says. Doubts mount that Gujarat shareholder deal won’t help unpaid workers (0) October 9, 2013 A letter read to workers by Gujarat NRE’s general manager has cast doubt over a whether a share deal next week aimed at saving the company will go ahead. Newcrest announces new CEO and chairman (0) October 9, 2013 Newcrest has appointed a new chairman and a new CEO, as Greg Robinson steps down. NT iron ore project ships first load to China (0) October 9, 2013 A new iron ore mine in the Northern Territory shipped its first load to China yesterday for testing in steel mills. Alliance Aviation extends FIFO contract with Newcrest (0) October 8, 2013 Alliance Aviation Services will provide FIFO services to Newcrest’s Telfer mine for a further three years after the miner signed up to extend the current contract. FMG fights Brockman’s attempt to secure railway access (0) October 8, 2013 Fortescue Metals Groups is appealing a ruling which forces it to negotiate with its Pilbara neighbour Brockman Mining over access to railway infrastructure. Business confidence rises in the mining industry (0) October 8, 2013 A quarterly Business Confidence report by Roy Morgan has highlighted a return in optimism for the mining sector. Helensburgh coal miners continue strike action (159) October 8, 2013 200 workers from Peabody’s Helensburgh Metropolitan Colliery went on strike again yesterday as the dispute around new enterprise agreements remains unresolved. Mining readies itself for Movember (0) October 8, 2013 Mo’ money means more healthy miners, as the industry prepares for Movember. 35,000 new mining jobs to be created in South Australia (0) October 8, 2013 According to a new report, South Australian resource companies will require an extra 35,000 employees if 40 new mining and infrastructure projects get off the ground by 2030. WA’s mine safety record improves (0) October 8, 2013 The ratio of mining deaths to those employed in the sector has fallen, a review of all WA mining fatalities over the past 13 years shows. Gold miners unite to block royalty hikes (0) October 8, 2013 Western Australia’s gold miners are uniting; establishing the Gold Royalties Response Group (GRRG) to stand up to the state government over potential gold royalty hikes. Orica announces new head of mining division (0) October 8, 2013 Orica has appointed Nick Bowen as the executive global head for mining services. $5bn boost for North West Shelf (0) October 8, 2013 Woodside has extended the life of its North West Shelf LNG plant with a $5 billion upgrade to the North Rankin field. Mining exports set to surge: BREE (1) October 8, 2013 Australia’s resources sector is transitioning from a construction to a production phase which Industry Minister Ian Macfarlane says will deliver “serious money” and boost exports. Pro-nuclear greenies? Thinking outside the box with Pandora’s Promise (0) October 8, 2013 As humanity faces the danger of global warming, what other options can we look at for future power sources. Fortescue install automated trucks at its Solomon Hub Kings mine (889) October 4, 2013 Fortescue Metals Group has installed Caterpillar autonomous trucks at its Solomon iron ore mine in the Pilbara. Alpha coal project court challenge awaits final submissions (0) October 4, 2013 Court proceedings to halt GVK Hancock’s major Alpha Coal Project are on hold as each side prepares its final submissions to the Queensland Land Court. Coal seam gas exclusion zones come into force (0) October 4, 2013 The New South Wales government’s coal seam gas exclusion zones will today come into effect. Mr Bechtel himself touches down in Gladstone (0) October 4, 2013 The CEO of Bechtel touched down in Gladstone this week to inspect the three LNG projects being constructed by his company on Curtis Island. Rio workers rescued from toxic red mud dam (0) October 4, 2013 Two operators left clinging to an overturned vehicle for several hours in Rio Tinto’s toxic alumina tailings dam have been safely rescued. Financial help on the way for Gujarat workers (0) October 4, 2013 The CFMEU has secured short-term hardship payments for workers at Gujarat NRE, with workers set to receive a week’s pay. Seafloor miner Nautilus Minerals wins case against PNG (0) October 4, 2013 Subsea miner Nautilus Minerals has won its arbitration case against Papua New Guinea. Helensburgh mine workers strike over pay (0) October 4, 2013 More than 200 hundred workers from Peabody’s Helensburgh Metropolitan Colliery have gone on strike for 48 hours after negotiations around new enterprise agreements stalled. Cat launches new block caving ore handling system (1218) October 4, 2013 Caterpillar has developed a new automated system for removing broken ore from block caving operations. Kiwi billionaires eyeing off tungsten juniors (0) October 4, 2013 A major New Zealand business is making waves in the tungsten space, taking positions in a number of juniors. Sirius gets serious: Extends Polar Bear gold anomaly (0) October 3, 2013 One of Australia’s strongest emerging juniors Sirius Resources has extended the zone believed to contain gold anomalies at its Polar Bear project in Western Australia. Linc Energy acquires Blair Athol coal mine, 100 mining jobs created (1232) October 3, 2013 Linc Energy has acquired Rio Tinto’s Blair Athol coal mine. Consolidated Tin to launch new mine (0) October 3, 2013 Tin is an industry that’s becoming increasingly vital to modern life. Collinsville locals question Glencore’s social licence to operate (0) October 3, 2013 Collinsville locals say ‘nothing solid’ came out of the meeting held with GlencoreXstrata yesterday on the future of the mine, with the company refusing to answer key questions around community ... Gujarat workers facing financial hardship told to contact their banks (0) October 3, 2013 The Australian Bankers Association has told Gujarat NRE workers who have not been paid to contact their banks sooner rather than later. 3000 bed mining camp gets the rubber stamp (0) October 3, 2013 Western Downs Regional Council has approved a 3000 bed mining camp for the Queensland town of Miles. New mammal fossil unearthed in coal mine (0) October 3, 2013 A new, extinct species has been unearthed in a Thai coal mine. style='height:250px; width:300px;'> The increasing importance of telecommunications networks in the mining industry comes on top of the technology-led transformation already underway, according to Vocus. ... Secure and reliable connectivity imperative to mining - Australian Mining Year 2020 cemented the importance of having a dependable and secure telecommunications network, as COVID-19 forced millions to work remotely and become more reliant on using technology to communicate. Vocus explains what’s next for the industry’s technology revolution.	cc/2021-04/en_middle_0086.json.gz/line1796981
__label__wiki	0.914307	0.914307	Sep 27, 2018 - World Palestinian president says Trump must change course to mediate deal Palestinians gather to watch Abbas address the UN. Photo: Abbas Momani/AFP/Getty Images Palestinian President Mahmoud Abbas today called on President Trump to rescind his decisions on Jerusalem and Palestinian refugees in order to be able to act again as a mediator between Israel and the Palestinians during his speech today at the UN General Assembly. Why it matters: The White House was closely following Abbas's speech and wanted to see if Trump's overture about the two state solution would be answered by Abbas. Abbas didn't answer it directly, but Palestinian officials say he had prepared several versions of the speech and, after Trump's press conference, decided to use the most moderate one, which didn't contain personal attacks against Trump. The Palestinian President said he was optimistic at first about the Trump peace initiative, then added: "But we were shocked by decision and actions he took that completely contradict the role of the U.S. in the peace process." Abbas said in his speech that the Trump administration has reneged on all the U.S. commitments to the Palestinians and "undermined the two state solution." "It is ironic that the American administration still talks about what they call the deal of the century. But what is left for the administration to give to the Palestinians? Humanitarian solutions?" Abbas said in his speech the Palestinians will not accept "sole American mediation in the peace process" due to the Trump administrations recent decisions on Jerusalem, UNRWA and the Jewish settlements in the West Bank. He called on Trump to reverse those decisions. Sara Fischer, author of Media Trends 5 hours ago - Economy & Business Illustration: Rebecca Zisser/Axios The big picture: Positive fourth-quarter results show Netflix's resiliency, despite increased competition and pandemic-related production headwinds. Courtenay Brown Janet Yellen plays down debt, tax hike concerns in confirmation hearing Treasury Secretary nominee Janet Yellen at an event in December. Photo: Alex Wong via Getty Images	cc/2021-04/en_middle_0086.json.gz/line1796987
__label__wiki	0.806859	0.806859	futurama series finale review ©2013 Futurama TM and ©2013Twentieth Century Fox Film Corp. All Rights Reserved Leela and Fry in FUTURAMA - Season 7 - TV Review: FUTURAMA – Season 7 – “Meanwhile” – Series Finale The Matt Groening created series signs off again with a touching farewell By CARL CORTEZ / Contributing Editor Posted: September 5th, 2013 / 10:02 AM Stars (voices): Billy West, Katey Sagal, John Di Maggio, Tress MacNeille, Maurice LaMarche, Phil LaMarr, Lauren Tom, Dave Herman Writer: Ken Keeler Director: Peter Avanzino Network: Comedy Central, Wednesday nights Airdate: September 4, 2013 The series finale of FUTURAMA - Season 7 \| ©2013 Futurama TM and ©2013 Twentieth Century Fox Film Corp. All Rights Reserved How many times do we have to say goodbye to FUTURAMA. The former Fox series continues to defy the odds, first coming back as a series of direct-to-DVD movies and then for a four year, two season run on Comedy Central. The Comedy Central series finale “Meanwhile” is classic FUTURAMA and once again wraps things up by focusing on the core relationship of the futuristic series – the long gestating romantic relationship between Leela and Fry. And this time, it’s about marriage for the two. In a sweet and affecting episode, “Meanwhile” begins with Professor Farnsworth introduces his latest invention – the ability to go back in time 10 seconds. It seems like an innocent enough device – how bad could things go wrong in 10 seconds, but true to FUTURAMA form, things go wrong pretty quickly. Fry steals the device, so he can relive proposing to Leela over and over again. However, when she doesn’t show up to the rendezvous point on the Vampire State Building (and assuming she doesn’t want to be with him), Fry decides to jump from the building. Of course, messing with time has set his watch back and Leela is actually on time. Now Fry ends up in a continuous loop of plunging to his death until the problem can be solved. Eventually Leela helps save Fry, but he breaks the device. This results in a mixture of two classic TWILIGHT ZONE episodes “A Kind of A Stopwatch” and “Time Enough At Last.” The nice part, is these little nods don’t turn to tragedy, instead, it allows Leela and Fry’s relationship to flourish into old age. Even though the rest of the world has frozen around them, they now get to spend their lives together exploring the world and finally focusing on their love for one another. There are many sweet moments to “Meanwhile”, but the episode doesn’t shy away from the show’s trademark humor either (watching Fry plunge to his death in a gory display is quite funny). There isn’t much time spent with saying goodbye to other characters either. It really gets down to business and makes this about Leela and Fry, which is why the episode works so well. And the brief, bittersweet moment at the very end of the episode is a perfect loop to bring everything back around, so, if for some chance FUTURAMA cheats death again, there’s an open door for more. FUTURAMA has proven, throughout its seven seasons, that an animation series can be both ambitious, daring and very funny. It’s always been highly original and the animation has been top notch from the beginning. Anyone who has watched the show from the beginning can respect its evolution and the intelligence that goes into creating these episodes. It’s trademark wit and heart will be missed, but the fact that we’ve been given an additional four years with these characters, is the best gift of all. All hail FUTURAMA, and now let’s party like it’s 1999. Related: Interview with Katey Sagal on the end of FUTURAMA Related:Exclusive interview with OUT THERE and FUTURAMA voice actor John DiMaggio Related: Exclusive Interview with Katey Sagal on SONS OF ANARCHY and FUTURAMA Related: Exclusive Interview with FUTURAMA voice actor Maurice LaMarche AGREE? DISAGREE? LET YOUR VOICE BE HEARD – COMMENT BELOW! Related: TV Review of FUTURAMA – Season 7 – “The Six Million Dollar Mon” Related: TV Review of FUTURAMA – Season 7 – “The Thief of Baghead” Related: TV Review of FUTURAMA – Season 7 – “Decision 3012” Related: Exclusive Interview with David X. Cohen on the future of FUTURAMA – Part 2 Related: Exclusive Interview with David X. Cohen on Season 6B of FUTURAMA – Part 1 Related: Review of THE FUTURAMA HOLIDAY SPECTACULAR Article Source:Assignment X Article: TV Review – FUTURAMA – Season 7 – “Meanwhile” – Series Finale TV Review: GLEE - Season 3 - “On My Way” Exclusive Photos from the HANSEL AND GRETEL: WITCH HUNTERS Los Angeles... David Tennant chats about his new thriller BAD SAMARITAN - Interview Movie Review: MISS JUNETEENTH Tags: A Farewell To Arms, Bender, Billy West, Calculon, Chris Travers, Comedy Central, Dave Herman, Decision 3012, Fry Am the Egg Man, Futurama, Goonies, John Di Maggio, John DiMaggio, Katey Sagal, Langdon Cobb, Lauren Tom, Maurice LaMarche, Meanwhile, Phil LaMarr, Season 7, season premiere, series finale, The Bots and the Bees, The Six Million Dollar Mon, The Thief of Baghead, The Unknown Comic, Tip of the Zoidberg, Tress MacNeille, wedding, Xazzar, Yeti	cc/2021-04/en_middle_0086.json.gz/line1796992
__label__cc	0.56795	0.43205	Background Briefing Briefingsdeutsche bankfinancemass shootingmental healthnew zealandpsychologyterrorism Background Briefing: March 20, 2019 On March 20, 2019 March 27, 2019 By gram New Zealand’s Response to Erdogan’s Demagoguery We begin and go to New Zealand to speak with William Harris, a Professor of Politics at the University of Otago where he teaches the politics and history of the Levant states whose latest book is “Quicksilver War: Syria, Iraq and the Spiral of Conflict”. As funerals begin for some of the 50 victims of last Friday’s shooting rampage at two mosques, we will discuss how New Zealand’s Prime Minister has acted quickly to reassure the country’s small Muslim population in contrast to Trump’s inability to even acknowledge that the victims are Muslims, and the PM’s swift response to enacting gun control measures which our Congress appears incapable of doing no matter how many massacres happen here and how many die every year from gun violence. We will also examine the cynical use of the tragedy by Turkey’s President Erdogan at campaign rallies in the elections underway in Turkey. With New Zealand’s Foreign Minister heading to Turkey for talks, presumably to complain to Erdogan about his comparisons to New Zealand soldiers invading Gallipoli in 1915 with a lone gunman’s attack on Muslims, we will contrast Erdogan’s cooperative tone in his op-ed in The Washington Post with what he is saying to his domestic audience as he continues to insist the gunman responsible for the massacres at the mosques did not act alone. A Psychological Explanation for Trump’s Manic Tweeting Then we seek a psychological explanation for Trump’s flurry of furious tweets over last weekend which prompted the husband of one of Trump’s top advisors to include the textbook diagnosis of narcissistic personality disorder in his warning to the public that our president’s mental condition is worsening. Dr. Bandy Lee, a forensic psychiatrist on the faculty of Yale School of Medicine and co-founder of Yale’s Violence and Health Study Group who is the editor of the new book “The Dangerous Case of Donald Trump: 37 Psychiatrists and Mental Health Expert Assess a President”, joins us. The Intensifying Scrutiny of Trump’s Relationship with Deutsche Bank Then finally we look into the other bad news along with the details of the Cohen search warrants which have Trump rattled and that is the revelations about the billions loaned to Trump by Deutsche Bank at a time when Trump was blackballed by Wall Street. James Henry, an economist, lawyer and investigative journalist who specializes in global banking, debt crises and tax havens and is the author of “Blood Bankers”, joins us to discuss the intensifying scrutiny of Trump’s relationship with Deutsche Bank. Select a Daily Briefing Listen When the show is Live MONDAY-THURSDAY: 5-6PM SUNDAY: 11AM-NOON PT © 2018 PUBLIC TRUTH MEDIA FOUNDATION \| ALL RIGHTS RESERVED © 2018 PUBLIC TRUTH MEDIA FOUNDATION. \| Theme: Newslite Pro by eVisionThemes	cc/2021-04/en_middle_0086.json.gz/line1796996
__label__cc	0.597569	0.402431	Dinky Hocker shoots smack! Is it irresponsible to speculate? It is irresponsible not to. Verified, but limited! Where tasty lettuce and good mustard aren’t elitist. Let there be snark. The willow is too close to the house. Tick tock motherfuckers! Tick fucking tock! Wow, I can’t imagine what it was like to comment in morse code. I personally stopped the public option… No offense, but this thread hasn’t been about you for quite a while. Wow, you are pre-disappointed. How surprising. Deploy the moving finger of emphasisity! It’s not even safe to go out and pick up 2 days worth of poop anymore. I thought we were promised Infrastructure Week. A snarling mass of vitriolic jackals A last alliance of elves and men. also pet photos. You are either for trump or for democracy. Pick one. If senate republicans had any shame, they’d die of it. This really is a full service blog. Technically true, but collectively nonsense You are here: Home / Healthcare / COVID-19 Coronavirus / Send this Motherfucker to Jail Send this Motherfucker to Jail by John Cole \| March 19, 2020 5:26 pm \| 159 Comments This post is in: COVID-19 Coronavirus, Assholes, The Republican Crime Syndicate Jesus H. Christ: The chairman of the Senate Intelligence Committee warned a small group of well-connected constituents three weeks ago to prepare for dire economic and societal effects of the coronavirus, according to a secret recording obtained by NPR. The remarks from U.S. Sen. Richard Burr were more stark than any he had delivered in more public forums. On Feb. 27, when the United States had 15 confirmed cases of COVID-19, President Trump was tamping down fears and suggesting that the virus could be seasonal. “It’s going to disappear. One day, it’s like a miracle. It will disappear,” the president said then, before adding, “it could get worse before it gets better. It could maybe go away. We’ll see what happens.” “There’s one thing that I can tell you about this: It is much more aggressive in its transmission than anything that we have seen in recent history,” he said, according to a secret recording of the remarks obtained by NPR. “It is probably more akin to the 1918 pandemic.” But wait, it gets better: Soon after he offered public assurances that the government was ready to battle the coronavirus, the powerful chairman of the Senate Intelligence Committee, Richard Burr, sold off a significant percentage of his stocks, unloading between $582,029 and $1.56 million of his holdings on Feb. 13 in 29 separate transactions. As the head of the intelligence committee, Burr, a North Carolina Republican, has access to the government’s most highly classified information about threats to America’s security. His committee was receiving daily coronavirus briefings around this time, according to a Reuters story. A week after Burr’s sales, the stock market began a sharp decline and has lost about 30% since. On Thursday, Burr came under fire after NPR obtained a secret recording from Feb. 27, in which the lawmaker gave a VIP group at an exclusive social club a much more dire preview of the economic impact of the coronavirus than what he had told the public. These people are traitors. Previous Post: « COVID-19 Issues: Finding, or Making, Masks Next Post: Respite Open Thread: Who’s Got Something Happy to Share? » Alexandra Petri does Trump. This is such bullshit. And I have zero faith anything will happen to him because of it. (Returns to surfing Netflix looking for documentaries about the French and Russian Revolutions) All non-life-sustaining businesses in PA are ordered to close. unloading between $582,029 and $1.56 million of his holdings on Feb. 13 in 29 separate transactions. Damn. Just…. Damn. I’m sure it was just a misunderstanding. Burr won’t be the only one. Expect to hear soon about dozens of senators and congresspersons who did the same thing. Trump was apparently the only one in denial about how bad the stock market would be hit. Also, too, don’t be surprised when it turns out day-trading by Trump friends is creating the daily yo-yoing for profit. Okay Tar Heels, are the tumbrel wheels greased up and ready to go? BGinCHI We’re gonna need some new laws once we’ve scoured the body politic of these parasites. Jeffro Did not know he sold his stocks off in advance like that…wow…not surprised, just didn’t read that far. Holy cow, America: they really are willing to let us all die just to stay in power/live high on the hog. @Shalimar: Probably Mnuchin himself. // Lord Fartdaddy (Formerly, Mumphrey, Smedley Darlington Mingobat, et al.) But, but, but her e-mails! WaterGirl @Martin: I assume that means storefronts? Or is it everything? Related to the family where so many of them have it? The Moar You Know Not a word to be use lightly. I fully agree. They are traitors in the literal, Constitutional sense of the word. LivinginExile Watergirl A test. PenAndKey How is that not clearly a major insider trading violation? Martha Stewart went to jail for far, far less @The Moar You Know: even knowing what the punishment is for treason I’d be more than willing to see them prosecuted for such once next year starts. @PenAndKey: Members of Congress are specifically excluded from insider trading laws Among many, many other laws they exclude themselves from. @Jeffro: Yup. Fortunately, the virus doesn’t know how much one makes, so we need to protect ourselves. @Jeffro: My wife has been saying for a few years that was the plan. I thought she was being silly. I was so fucking wrong. There’s too many of us, far more than the uber-monied need for servants, and it looks like the plan is to kill most all of us off. Ella in New Mexico If I recall, I was reassured here several days ago that the vast majority of trading on the stock exchange was being conducted by algorithms and computer programs, not people… schrodingers_cat They threw the book at Martha Stewart. Richard Burr should be tried for insider trading. @WaterGirl: Unclear It’s hard to figure out where that line would be. Lot of food processing in PA – do they close? We need food. If you’re a material supplier to a medical device company? Nah, fine him 31 million. Seize his property and banish him from the senate Elizabelle On February 7, Richard Burr and Lamar Alexander wrote this op ed for Fox News. Sen. Alexander & Sen. Burr: Coronavirus prevention steps the U.S. government is taking to protect you …. Thankfully, the United States today is better prepared than ever before to face emerging public health threats, like the coronavirus, in large part due to the work of the Senate Health Committee, Congress, and the Trump Administration. The work of Congress and the administration has allowed U.S. public health officials to move swiftly and decisively in the last few weeks. The Centers for Disease Control and Prevention (CDC), along with airport security and Customs and Border Protection officials, are screening incoming passengers at airports as they arrive in the United States from China. [BUT THEY NEVER SCREENED PASSENGERS ARRIVING FROM EUROPE ONCE IT WAS OBVIOUS COVID19 WAS THERE, TOO.] … Health and Human Services (HHS) is training state and local health departments on the symptoms of the coronavirus. The CDC has developed a diagnostic test that detects coronavirus infections and the U.S. Food and Drug Administration is prepared to expedite its review. [ALTHOUGH TRUMP PASSED ON AN AVAILABLE AND EFFECTIVE TEST FROM THE WORLD HEALTH ORGANIZATION.] The White House has convened a Coronavirus Task Force [MIKE PENCE!], HHS has declared a public health emergency for the U.S. to help state and locals with the response efforts, and the National Institutes of Health, along with drug manufacturers, are expediting the development of a vaccine. [DUE IN MAYBE 18 MONTHS, UNLESS WE ARE UNCOMMONLY LUCKY.] …. article concludes: No matter the outbreak or threat, Congress and the federal government have been vigilant in identifying gaps in its readiness efforts and improving its response capabilities. The public health preparedness and response framework that Congress has put in place and that the Trump Administration is actively implementing today is helping to protect Americans. Over the years, this framework has been designed to be flexible and innovative so that we are not only ready to face the coronavirus today but new public health threats in the future. How did that work out? Sixteen days later, Burr is warning the Tar Heel Circle — privately — of what the US can actually expect. Mary G @Shalimar: FTFNYT says not so: Ex-Rep. Chris Collins Gets 26-Month Prison Sentence in Insider Trading Case If I remember right, he was photographed standing outside the White House making the call after a meeting there. MazeDancer Gonna be hard for Mitch to allow an investigation. But gotta do it in 2021. @Shalimar: But the STOCK act was designed to stop exactly this, and this looks like a clear violation of that act. Members of Congress are specifically excluded from insider trading laws The Stock Act doesn’t say that https://en.wikipedia.org/wiki/STOCK_Act SiubhanDuinne Jail? A jail for life sentence would be much too kind. I’m thinking more along molten-lead/boiling-oil lines, myself. Betty Cracker Jail yes, but also seize all his assets and distribute them to his victims. These people need to start fearing the consequences of their actions, and a short stint in Club Fed followed by a return to the family manse isn’t scary enough. Maybe the prospect of eking out a paycheck-to-paycheck living would teach the senator a valuable lesson. @Mary G: I might be remembering incorrectly, but I think Collins’ crime was sharing info with family members, not selling his own shares. @Betty Cracker: I nodded my way through every word of each of your three sentences. NPR: Intelligence Chairman Raised Virus Alarms Weeks Ago, Secret Recording Shows [Richard Burr, the] chairman of the Senate Intelligence Committee warned a small group of well-connected constituents three weeks ago to prepare for dire economic and societal effects of the coronavirus, according to a secret recording obtained by NPR. The remarks … were more stark than any he had delivered in more public forums. On [February 27, as Trump was suggesting the virus might just disappear], Burr [spoke at a luncheon in DC for “The Tar Heel Circle” of NC business leaders] and …. delivered a much more alarming message. The message Burr delivered to the group was dire. Thirteen days before the State Department began to warn against travel to Europe, and 15 days before the Trump administration banned European travelers, Burr warned those in the room to reconsider. “Every company should be cognizant of the fact that you may have to alter your travel. You may have to look at your employees and judge whether the trip they’re making to Europe is essential or whether it can be done on video conference. Why risk it?” Burr said. Sixteen days before North Carolina closed its schools over the threat of the coronavirus, Burr warned it could happen. “There will be, I’m sure, times that communities, probably some in North Carolina, have a transmission rate where they say, ‘Let’s close schools for two weeks. Everybody stay home,’ ” he said. And Burr invoked the possibility that the military might be mobilized to combat the coronavirus. Only now, three weeks later, is the public learning of that prospect. “We’re going to send a military hospital there; it’s going to be in tents and going to be set up on the ground somewhere,” Burr said at the luncheon. “It’s going to be a decision the president and DOD make. And we’re going to have medical professionals supplemented by local staff to treat the people that need treatment.” Burr …. helped to write the Pandemic and All-Hazards Preparedness Act (PAHPA), which forms the framework for the federal response. But in his public comments about the threat of COVID-19, Burr never offered the kind of precise warning that he delivered to the small group of his constituents. Because Burr knew about this and did not want to go against the vindictive Trump. Burr has already announced he is retiring in 2022. @Ella in New Mexico: Ok, good. Did not know that law had passed in the last decade. Immanentize @Ella in New Mexico: It is. 70% of trades are bots. But why did you think that was reassuring? mrmoshpotato @Lord Fartdaddy (Formerly, Mumphrey, Smedley Darlington Mingobat, et al.): I think you’ll appreciate this. MelissaM Cole, you are not wrong. Assholes. @schrodingers_cat: Congress Critters expressly took themselves out of insider trading laws. @Shalimar: Collins had specific inside information about a specific company — he was told by the CEO or some other executive that the results of clinical trials were much less successful than they needed to be. He got off that phone call and called his son, who, no doubt, he had encouraged to invest in the company. His son (and maybe others) then sold a lot of stock before the news became public. The information here is what you would call non-company specific information. Dude is a horrible person and a traitor, but I doubt if this qualifies as insider trading as defined by the securities laws. Burr is not going to be the only Senator/Member of Congress/Trump administration official who dumped stocks before the public realized the extent of the coming pandemic. In time, the House should investigate all of them. Be interesting to find out what’s up with Fox News’s finest gazillionaires, too. @Mary G: That was because it wasn’t his trade — it was his son’s. Conspiracy. Typical prosecutor plea behavior: Either you can go to jail, or your son will go for life. Using one’s position with the secret data he gets to maximize his holdings isn’t kosher. This should be branded on his head so no one ever forgets. @Shalimar: IANAL, but I think using insider information is illegal whether or not the shares sold belong to the legislator ETA: Actual lawyers chime in to tell me I am wrong. Sorry. Yutsano @Betty Cracker: a short stint in Club Fed I already see the problem. This is why Biden HAS to win in November. Burr should not only lose his seat over this, he should have a nice long stint in the pokey as well. And I am all about some old fashioned asset forfeiture as well. Nice thing about NPR breaking this story: For once they didn’t “both sides” their coverage. Well, so far, anyway. Can’t decide if this kind of shit pisses me off more or the fact that the Republicans in the Senate are simultaneously working to either stop or significantly water down the cash payments to taxpayers being proposed, to point that many middle class families will not qualify for any assistance or will get sharply reduced amounts Because God knows when you make 110K you have a year’s salary in the bank and there’s no way one of you taking time off for illness for a month could tank your entire family’s finances. Senate GOP direct cash plan: —$1,200 check per person —Phases out starting $75K income —Lowered $5 for each extra $100 —Add $500 per child —No $ for incomes $99,000+ —Based on 2018 tax return 3:26 PM · Mar 19, 2020 https://twitter.com/sahilkapur/status/1240751566493224962?s=20 @Elizabelle: He shouldn’t be allowed to retire with a fat pension and Cadillac healthcare plan, not after this stock scandal. Cole is right; that motherfucker needs to go to jail. The Dangerman @PenAndKey: How is that not clearly a major insider trading violation? Martha Stewart went to jail for far, far less. We will need to build new Hospitals that convert easily to Prisons. Slammer Time. Can’t touch that (your face). Aardvark Cheeselog I looked at the Wiki page for the STOCK Act and if it specifies any penalties for violations, they aren’t mentioned. It’s noteworthy, how many things are prohibited by Federal law, but it turns out there’s no consequence for the violation. Almost like “it’s against the law” is supposed to be deterrent enough for a public official. @Elizabelle: My tinfoil hat thinks that might explain why FOX people suddenly turned on a dime. Everyone had made their quick buck (millions) so then they could start telling the truth. Reminder: In 2012, the Senate passed the Stop Trading on Congressional Knowledge Act (STOCK Act) by a 93-2 vote. One of the two who voted against it was Richard Burr. https://t.co/gqIaYHeevA— Walter Shaub (@waltshaub) March 19, 2020 Gorgeous day here in RVA. Out for a socially distanced walk in the park. lamh36 Trump’s directed governors to buy their own medical supplies, but one governor said when his state tried to do so it got outbid — by the federal government https://www.bloomberg.com/news/articles/2020-03-19/trump-told-governors-to-buy-own-virus-supplies-then-outbid-them via @bpolitics waspuppet You don’t understand! If Richard Burr loses money, it’s a national security risk! You couldn’t possibly expect him to not sell secrets in order to keep his fourth boat. @Betty Cracker: A lot of them do. Wonder what Mitch and his wealthy family did. Asset forfeiture, you’re right about stripping the pension and the healthcare (let them use Medicare). Will be expensive to prosecute these well-connected crooks … Burr also slow-walked his committee’s findings on how Trump benefited from Russian interference. @Immanentize: I didn’t–I was complaining that the way the stock market has been behaving makes me think people were attempting to artificially manipulate it and thus make lots of bucks selling high then waiting for the right moments to buy back low, and shouldn’t we find a way to halt that kind of thing… West of the Cascades Cal Cunningham is going to have some wonderful material to work with for his campaign ads (and hopefully Steyer and Bloomberg will create “TURNTHESENATEBLUE” PACs to blanket the airwaves in a dozen states with competitive Senate races, too). I think Burr should be forced to man a drive-up clinic 40 hours a week without a mask. Each patient that arrives he needs to say ‘I’m Senator Richard Burr and I profited off of your potential illness. I need to take a nasal swab.’ Red states, god help them: So get this. Monday night Fayetteville had a city council meeting and passed a resolution to give our mayor temporary power to guide our city based on CDC recs. Today, Arkansas Gov announced in a press conference he and only he will make decisions. Basically telling mayors ..— 🌈DemocratWithABigDFruitKace💅🏽 (@FruitKace) March 18, 2020 across the state to stfu and quit trying to be all good at your jobs by trying to make cities as safe as possible .. bc he’s in charge.— 🌈DemocratWithABigDFruitKace💅🏽 (@FruitKace) March 18, 2020 Goku (aka Amerikan Baka) Blast from the past: Sen. Burr: STOCK Act was a waste of time Burr, along with Sens. Jeff Bingaman (D-N.M.) and Tom Coburn (R-Okla.), were the only members of the Senate to vote against the bill on Feb. 2. Burr pointed out in his letter that it is already illegal for congressmen – or anyone – to engage in insider trading. “Insider trading activity is illegal for all Americans including government employees, members of Congress and congressional staff,” he wrote. Burr’s letter was apparently in response to criticism he has taken for his vote against the bill, which many in Congress proclaimed as a giant step toward transparency and self-regulation. @West of the Cascades: I really hope Biden’s campaign and Bloomberg use, “No, I don’t take responsibility at all.” Mind boggling. You never say that shit as a leader. All the AM radio RWNJ have gone full North Korea, praising Trump for his “leadership”: “Where would we be if Trump wasn’t President”? All these BS right-wing takes will age like milk a few weeks cckids @Martin: NV did it Tuesday. So many people out of work. 8 man shell @Ella in New Mexico: That’s still true. Last time I checked a couple of years ago, the _daily_ NYSE volume in dollars was about $175B. Ksmiami @BGinCHI: and tumbrels lots and lots of tumbrels. The GOP is hazardous to your health I love this so much. low-tech cyclist Gitmo. Send that fucker to Gitmo. As soon as there’s a Democratic Administration, it should turn Gitmo into a prison for all the crooks of the Trump Administration (definitely including the Mango Mussolini himself) and the GOP generally. I never imagined trump’s face color could look more grotesque, like skin on corpse dried out in a desert. (Note to self … next time, glasses that you don’t have to push up with a finger without thinking about it. Also, let the nose itch, DAMMIT.) So, this is why there are blind trusts, huh, Donald (I bet he was dumping shit …. ewww, I know … like crazy)? Can’t decide if I am angry about Barr’s blatant corruption and lack of concern for the people he represents or because he will still win because our fellow citizens in most states will vote for a republican no matter what. @bemused: Copper kills viruses, so more bronzer means more protection. Jim, Foolish Literalist @Anya: Thilis is the one up for re-election this cycle, he’s been polling a few points behind Cunningham, but this could be contagious to Tillis. This is the kind of thing people understand Burr has previously said he’s retiring and not running for reelection. Scott Alloway @Martin: Farming and science excluded, as are gas stations and pharmacies. See this link: https://6abc.com/health/gov-wolf-orders-all-non-life-sustaining-businesses-in-pa-to-close/6026757/ Le Comte de Monte Cristo, fka Edmund Dantes Martha Stewart went to prison for less. @Mary G: I believe that’s called Take the Money and Run. @WaterGirl: https://www.youtube.com/watch?v=-WCFUGCOLLU Mallard Filmore @low-tech cyclist: Trump will pardon himself and many of his co-conspirators making prosecution difficult politically and legally. We will need to send many of these crooks to The Hague instead. @Jim, Foolish Literalist: Agreed. Friends and family dying is something people will understand and blame Trump for. It’s sad that be what it takes but here we are @Mallard Filmore: The states could still prosecute him @raven: Nice to have you back! @Anne Laurie: It was amended a year later to weaken those restrictions. Because of course it was. A year later would’ve been 2013 or so. Did Senate Dems initiate the changes? I try not to read too much into twitter, but “Burr” is trending. Good. @Goku (aka Amerikan Baka): Sure! After The Hague. sherparick None of this would have surprised George Carlin, Joseph Heller, Mark Twain, or Kurt Vonnegut. As George says, “There is a Big Club, and you & I are not in it.” https://www.youtube.com/watch?v=i5dBZDSSky0 If you want a face to match the phrase “A Fucking Cocksucker who does not care” – in this case that thousands of North Carolinians, including many who voted for him, may die over the next couple of months, Senator Richard Barr will do. Another Scott @raven: Howdy stranger. Scott. Sister Golden Bear At today’s press conference, San Mateo County Public Health described the situation here as “somewhere between dire and catastrophic.” 😱 😭 🤬 The hardware stores are open, so I can stock on pitchforks and torches, but making it to D.C. may be a problem. But with Home Depot open, at least there’s time to Quarantine Pro Tip: Get Yourself A Lesbian // You’ve probably heard jokes about queer female couples staying in at night and U-Hauling — the phenomenon in which new lesbian couples get so attached so quickly that they shack up together after the first date. This is what we do. This is where we thrive. Welcome to our culture. I’m actually encouraging you to appropriate it as a means of public safety. For your own good: Get a lesbian, now. This may seem like a pyramid-scheme-like sales pitch, but it’s actually more of a surgeon general warning: If you want to survive this pandemic, invite a queer woman into your home and let her do her thing. She’ll know what to do. All you have to do is emotionally support her in return. Here’s what getting a lesbian during the apocalypse can do for you: My people can teach our survival skills to straight folks, including 101 ways to make hummus. #QueerHumor @raven: Hey! How’re you holding up? @WaterGirl: Yo ya’ll. It's pretty bad when you've just become the worst Burr in American political history…and No. 2 is the guy who shot and killed Alexander Hamilton— Will Bunch 🆘 (@Will_Bunch) March 19, 2020 @Goku (aka Amerikan Baka): We’re ok. Great neighborhood full of kids we can yell across the street at. Our local government is going to bump it up a level tonight but, like everywhere else, this is a service based community and people are going to be in a world of hurt. It’s hard to figure out who and when to help. Time for political violence and blowing shit up. I may as well use my anxious sleepless time for planning to deal with conservatives. @Nicole: TCM had The Battleship Potemkin on the other day. I swear they program to comment on the current situation, whatever that may be. Lots of political films during the Impeachment process. @trollhattan: How is that not insider trading? tomtofa NPR headline fixed to make it more accurate: Intelligence Chairman privately Raised Virus Alarms Weeks Ago, then dumped stocks, Secret Recording Shows. My community is in the same boat. We’re a retail hub. Everything’s closed, aside from gas stations and supermarkets. Hope you and your wife stay safe and I’m glad you came back It’s interesting that CNN and MSNBC haven’t been reporting the Burr thing as “breaking news” I guess maybe they are trying to confirm the reporting? The Thin Black Duke @raven: Welcome back, dude. @SenatorBurr FollowFollow @SenatorBurr In a tabloid-style hit piece today, NPR knowingly and irresponsibly misrepresented a speech I gave last month about the coronavirus threat. Let me set the record straight. 1/ 5:27 PM – 19 Mar 2020 Burr responding to the “lesser” scandal…smh https://twitter.com/SenatorBurr/status/1240766943449276424 Timurid @SiubhanDuinne: Bring back the Brazen Bull. hells littlest angel More likely — and just — he’ll be stoned to death by an angry mob. zhena gogolia @Sister Golden Bear: That’s sweet. So, I routinely talk about how China’s appeal to manufacturers is speed. 45-90 day review before mask production can be started. China not only got approval out, but got factories running in a week. 5% lower wage costs is nothing compared to no production for 3 months. geg6 You can read a whole list of what is allowed and not allowed. From what I saw on the list has not materially changed from yesterday. It has just changed from a request by the state to a mandate by the state. Apparently, not enough people across the state were complying with the request, so he had to take the next step. Patricia Kayden Usually, difficult times like these bring out the best in people.But Sen. Burr…- Knew about the shitstorm coming and told high-priced donors- Then he dumped $1.6M in stockMartha Stewart went to jail for that.Jail is TOO GOOD for him.https://t.co/d6MRb8QcK1— BrooklynDad_Defiant! (@mmpadellan) March 19, 2020 A Ghost to Most @Sister Golden Bear: Can you kill and clean a rabbit? @lamh36: “Tabloid-style hit piece.” “Daddy, what’s a ‘tabloid’?” He’s so twentieth century. NotMax @Ella in New Mexico based on 21018 tax return</blockquote. So those of us (raises hand) who didn't make enough to file a return are shut out. Whoopee. O. Felix Culpa @SiubhanDuinne: Ah, I like your mob enforcer mode. @debbie: Mnuchin is probably an actual multi-billionaire by now. The most pathetic thing is that the Trump clan could’ve already quietly built up a fortune rivaling that of the world’s wealthiest people with just insider trading–all the while publicly restraining their own visible business activities/expansions/licensing/etc “for the sake of clean government and avoiding conflict of interest”, but the siren’s call of bush-league grifting is just far too compelling. @A Ghost to Most: Been there, done that. And made a fabulous fur hand warmer out of it. #FemmeMacgyvering Jay Noble @Martin: The utter irony is that that it could be true. rikyrah So, I know people can be savvy investors but Richard Burr sold lawn equipment before he became a senator in 2005. How does one go from that, to a public servant salary, and amass $1.5 million in assets to begin with? juuuuust asking— Asha Rangappa (@AshaRangappa_) March 19, 2020 We’ll have to deal with Richard Frickin’ Burr when the time comes. I once read that his schtick was to attend Chamber of Commerce meetings and talk about the need to have corporations pay zero state income tax. Typical GOP Senator. But first in our sights is scumbag Thom Tillis, who’s tied himself to the mast of SS Trumptanic. Goin’ down, asshole. So, Trump and the Fox gang say we are now on a war footing. I’d say that gives the treason clause a lot more punch. And doesn’t war footing kinda bring up a few things concerning war profiteering? That pile of TP in your garage and your ebay listings might not be looking so smart They will all claim it don’t count because there was never a Congressional Declaration of War Senator Burr has put up a Twitter thread claiming that he is as innocent as a lamb: In a tabloid-style hit piece today, NPR knowingly and irresponsibly misrepresented a speech I gave last month about the coronavirus threat. Let me set the record straight. 1/— Richard Burr (@SenatorBurr) March 19, 2020 It’s about the NPR story, claiming that his speech was not secret, but the annual state meeting anybody could attend. So far nothing on the Pro Publica story on his stock sales. The first comment is “Resign” and most comments are elaborations on that theme and his going to jail. Jinchi I hadn’t heard that he sold off a million dollars worth of stock. And in the annals of chutzpah: Burr’s office also rebutted a ProPublica story indicating he sold between $500k-$1.6m in stock in the weeks leading up to the market collapse. An aide said the sale happened before market volatility began. https://t.co/Zf4fUp0vd3— Kyle Cheney (@kyledcheney) March 19, 2020 “I did it and fuck you.” @Shalimar: No they aren’t. The STOCK Act covers members of Congress. The really exasperating thing is that so much of America’s 401K retirement income is compelled to be invested in the stock market, and yet there’s no way for a typical person to simply “sell” all of that investment. We just take the ride all the way down. @Mary G: An aide said the sale happened before market volatility began Well, yeah, that’s the thing. @Mary G: An aide said the sale happened before market volatility began. Yeah. I think that’s the whole reason everyone is upset. burnspbesq @Thor Heyerdahl: securities fraud is a federal crime. VeniceRiley @Betty Cracker: Stay safe Betty https://www.tampabay.com/news/health/2020/03/19/smart-thermometer-company-may-predict-high-coronavirus-numbers-in-florida/ @Betty Cracker: jail…after a good tar-and-feathering and march across the entire length of his home state. Who’s with me? I’ll share my stash of rotten tomatoes with the crowd. He shouldn’t be allowed to retire with a fat pension and Cadillac healthcare plan, not after this stock scandal. Cole is right; that motherfucker needs to go to jail. And have all his assets confiscated, every house, every investment, every dime — no pension, no health care, I’ll allow him Social Security and Medicaid, but that’s it for me. After he gets out of jail, of course. @lamh36: Oh, a “hit piece” now, is it? Next thing you know, trumpublicans will be claiming they weren’t saying this was all a hoax back in February, while also trying to claim they were on top of the situation back in January, while also trying to claim Joe Biden sold us out to the Chinese in March. LOLwhut @Jay Noble: They’re convinced they can turn their PR problem around (they don’t care about the humanitarian crisis; job #1 is getting their PR back above water) by saying trumpov is a “wartime president” pretending this was some sort of Chinese plot against America, aided (but of course) by the Democrats They’re going to repeat it for the next eight months so get used to it. ballerat @lamh36: We have seen how Trump uses the federal government to punish his political opponents by withholding resources. And rewards his base by bestowing same. (re: fires in CA, storms on east coast, hurricane in Puerto Rico, bailouts for his base). As his inept response continued I sometimes wondered if he was trying to kill some of us. Incompetent, hell yes, but the opportunity is there. He’s used previous previous self-created crises and natural disasters as opportunities to economically, politically and, importantly, physically harm his enemies while rewarding his followers. But I couldn’t figure out how he’d pull off killing us blue staters this time without it looking so obvious. Now I think I know. Christ it’s starting to look more like genocide to me. Dmbeaster @PenAndKey: The insider trading law was modified under Obama to make this illegal (it was famously not illegal before that). Burr has been a Senator since 2005 and probably just remembered the good old days. @Shalimar: That was changed under Obama. @Dmbeaster: Pardons all around. Calouste @rikyrah: Senators get paid quite well ($175k or so) and he was in Congress 10 years before that. $1.5 million in assets in not out of the ordinary on 25 years of that income. He has almost the same elected career as Bernie “three houses” Sanders. Of course there is the question of how much he didn’t sell… US had a bad day. 2 days in a row of ticking slightly higher than trend. We’re 12 days behind Italy, and that had been stretching out because they were seeing a faster pace of fatalities. We’ll need to see when that starts to turn downward for us. No idea when that might be. Steeplejack (sky-high wi-fi) @tomtofa: Burr dumped the stocks (February 13) before he issued the private warning (February 27). Possible explanation: bad genes. Pardon me, I'm kin to Aaron Burr, sir. https://t.co/8f8bsJhhmr — Richard Burr (@SenatorBurr) July 11, 2018 Steeplejack (phone) @Steeplejack (sky-high wi-fi): Oops, need to reset my nym. Citizen Alan @MattF: I would almost get the WP subscription just to read Alexandra Petri every week, but I just can’t bear the thought of paying money even a miniscule percentage of which goes to people like Marc Thiessen. @rikyrah: So, I’ve amassed double that amount in less time on ⅓ of his salary. Two steps: Buy a house in SoCal when the market is soft. Make a fortunate investment. A few grand in Amazon or Apple at the right time will take you from a few thousand to a few million in that time. There’s literally nobody in my area that bought a house 15 years ago that isn’t a millionaire now, provided they weathered 2008. Burr’s office also rebutted a ProPublica story indicating he sold between $500k-$1.6m in stock in the weeks leading up to the market collapse. An aide said the sale happened before market volatility began. I think they are mistaking the problem for a defense. Yes, it was before the market volatility began. That is an admission, not a defense. We know it was before the market crashed, that’s why it was a crime. How stupid…. excuse me, he was a lawnmower salesman, so VERY stupid. @Martin: also, “sold lawn equipment” could cover a wide spectrum of employment, from retail sales to a smallish but successful business. He sounds like one of those guys who thinks he knows how gubmint should be run cause he ‘met a payroll’. I have not done that, but my father who did for over forty years said it was the silliest thing politicians bragged about. Biff Baxter As we all just knew, Burr wasn’t the only one. https://www.thedailybeast.com/sen-kelly-loeffler-dumped-millions-in-stock-after-coronavirus-briefing?ref=home Miss Bianca @NotMax: Or those of us who sold our house in 2018 and will show a way, way bigger income that year than any other year for the last 10. Sigh. So.Much.Winning. @Biff Baxter: um…. “Appreciate today’s briefing from the President’s top health officials on the novel coronavirus outbreak,” she tweeted about the briefing at the time. [ on1/24…] It was the first of 29 stock transactions that Loeffler and her husband made through mid-February, all but two of which were sales. One of Loeffler’s two purchases was stock worth between $100,000 and $250,000 in Citrix, a technology company that offers teleworking software and which has seen a small bump in its stock price since Loeffler bought in as a result of coronavirus-induced market turmoil Look for a ‘too rich to steal’ defense. When Loeffler assumed office she immediately became the wealthiest member of Congress. The Atlanta businesswoman, whose husband is the chairman and CEO of the New York Stock Exchange, is worth an estimated $500 million. @burnspbesq: I know securities fraud is federal…so let me rephrase (since it looks like Kelly Loeffler was pulling some hinky shit too): Okay everyone, are the tumbrel wheels greased up and ready to go? @Thor Heyerdahl: that would be a yes, TH @J R in WV: It’s material non public information- throw the book at them. @raven: Lovely to see you again! @Le Comte de Monte Cristo, fka Edmund Dantes: Treat them like the fascists they are.. PaulWartenberg We have AT LEAST Burr and Loeffler caught in the act of selling stocks about to get hit by the pandemic (and in Loeffler’s case she bought stock in companies about to see more business because of it). Anyone else remember Public Enemy’s “Bring The Noise”? It was the first time I ever heard the phrase “Corrupt Like a Senator.” I didn’t fully grok it until I was in college during the Bush years and the Anita Hill scandal broke and I got to witness clueless elderly white guys fail at their duty. This? This is 100 times more blatantly corrupt. WE JAILED MARTHA STEWART FOR LESS. @PaulWartenberg: Looks like Ron Johnson was in on this as well, and for even more than Burr and Loeffler @Jeffro: I hope to God there’s even more GOP Senators dumb enough to pull this stunt, and I hope to God somebody other than trump’s corrupt DoJ can bring them all to justice in a jail cell without bail, next to the 400 or so inmates they wanted to keep locked up while coronavirus rampages the prison systems. I wonder how Mitch gonna hold a quorum if 4 or more Republican Senators sitting in a cell on fraud charges. Mai naem mobile Burr’s Spokesmodel’s response to the Senator selling the stock is ‘lol.’ That’s her response – ‘lol.’ It’s like they need to be fed the corona virus on their caviar. Raven Onthill And we gave the two Presidential candidates with the strongest anti-corruption agendas – IIRC one of them even predicted something like this disaster – their walking papers. Yes, I’m bitter. @Raven Onthill: because neither one could figure out that “I’m going to take away your current health insurance” was a losing message the first step to being a good president is being a smart candidate @raven: look who’s stopped on by. Hello you! dww44 @Damien: Exactly the right punishment. @J R in WV: I know i should go google this, but was Burr actually a lawn mower salesperson? @Jim, Foolish Literalist: or perhaps voters just wanted someone they knew from the Obama administration. Whatever the case, the candidates who had the best ideas about responses to the current situation have been pushed away. Why does anyone competent even bother to run for elected office? @Raven Onthill: Why does anyone competent even bother to run for elected office? I’ll try typing this more slowly: You can’t be a competent president if you’re not a competent candidate first. Stop reading Jacobin and go read some polls: Eliminating private insurance isn’t popular, even if you call it “corporate” insurance. @Jim, Foolish Literalist: I don’t think that was what elected Biden. It came up for one or two news cycles and then faded away. (I avoid Jacobin except when something really useful is published there. I’m not that kind of leftist, never have been.) Charles Pierce, I think, has the right of it, here: people, at least the older voters who decided the primary, want a return to normality, and do not want to hear that there is no way back. If your estimate of me is that far off, and you have plenty of information about me, what makes you so sure of your estimate of primary voters about whom you have far less information? And, you know, if voters can’t take the trouble to look at a candidate’s record, why should any candidate bother to accumulate a good record? Just looking good on television seems to be enough. It is not hard to find out the basics of any candidate’s record any more, but older voters don’t seem to care. Brachiator on Respite Open Thread: Happy Birthday, Dolly Parton (Jan 19, 2021 @ 11:08pm) Benw on On The Road – Mike in Oly – Texture & Pattern in Nature: Water (Jan 19, 2021 @ 11:07pm) Jim, Foolish Literalist on Respite Open Thread: Happy Birthday, Dolly Parton (Jan 19, 2021 @ 11:07pm) Sister Golden Bear on On The Road – Mike in Oly – Texture & Pattern in Nature: Water (Jan 19, 2021 @ 11:06pm) Kayla Rudbek on Open Thread: A Few Hours To Go – Biden Live (Jan 19, 2021 @ 11:06pm)	cc/2021-04/en_middle_0086.json.gz/line1796998
__label__cc	0.626653	0.373347	Punon PUNON (pū'nŏn, Heb. pûnōn). A desert encampment of the Israelites marking the second stop after leaving Sinai (Num.33.42-Num.33.43). Eusebius identified it as being north of Petra, a penal colony where convicts were sent to mine copper, also called Phinon or Phainon. Eusebius is probably correct in this identification. PUNON pū’ nŏn (פּוּנֹֽן). Alt. PINON pi’ nŏn. A town in Edom, a desert stop in Israel’s wilderness sojourn (Num 33:42f.), on the second day after leaving Mt. Hor, and shortly before arrival at Moab. An important mining center, it was perhaps the home of an Edomite chieftain (Gen 36:41 has “Pinon” for Punon). The site at the juncture of two wadis has great copper slag heaps. Eusebius notes that in ancient times, convicts mined and converted the ore (Onomasticon 299 85: 123 9). Operations were perhaps as early as 2200-1800 b.c. Israel found it recovering after long desertion. Abandoned two hundred years later, it subsequently was revived by Nabateans, operation continuing through Rom. and later periods, seeing great prosperity. Here is the modern Feinan, a large well-watered city about five m. from the mining and smelting at Khirbet en-Nahas and Khirbet Nqieb Aseimer. The Byzantine period had a Christian basilica and monastery, the ruins yielding an inscr. with the name of Bishop Theodore (587, 588). N. Glueck, “Explorations in E. Palestine,” II, AASOR 15 (1934-1935), 32-35. A desert camp of the Israelites, the second after leaving Mt. Hor (Nu 33:42,43). Eusebius (Onom 299 85; 123 9) mentions an Idumean village, North of Petra, in the desert, where convicts were mining copper, called Phinon or Phainon. These are doubtless identical. See Wanderings of Israel.	cc/2021-04/en_middle_0086.json.gz/line1797000
__label__wiki	0.747118	0.747118	Opinions & Predictions Podcasts & Radio Shows A.L. East A.L. Central A.L. West N.L. East N.L. Central N.L. West It's Not Your Imagination: There Have Been Way Too Many Hall of Fame Deaths This Year Zimmerman, Ross, Leake First Players to Opt Out of 2020 MLB Season Due to COVID-19 An Open Letter to My Fellow Astros Fans Takeaways from this year’s Hall of Fame voting With Josh Donaldson in the Fold, the Minnesota Twins are Locked and Loaded for 2020 Pecos League Players to Ride the Amtrak Southwest Chief to Road Games Anton Joe The Pecos League announced on Tuesday evening that it will be partnering with Amtrak to transport players along the Southwest Chief Route during the 2015 season. The Southwest Chief is a higher-speed passenger train operated by Amtrak. The train travels along a 2,265-mile route through the Midwestern and Southwestern parts of the United States. It runs from Chicago, Ill., to Los Angeles, Calif., passing through the states of Illinois, Iowa, Missouri, Kansas, Colorado, New Mexico, Arizona and California. To the Pecos League’s convenience, the Southwest Chief will have stops in the cities of Lamy, N.M.; Las Vegas, N.M.; Trinidad, Colo. and Garden City, Kan. The Northern Division teams will ride the train from Las Vegas, N.M. to and from Garden City, Kan. They will have off-days on Mondays when they play in Garden City. Teams will leave on Mondays and return the following Monday. The train departs from Las Vegas and heads eastbound in the mid-afternoon every day, and departs from Garden City in the early morning every day. The Las Vegas Train Robbers, Santa Fe Fuego, Trinidad Triggers and Garden City Wind are members of the Northern Division. Anton Joe is an Independent League Baseball Reporter for Baseball Essential. You can follow him on Twitter @AntonJoe_BBE. AmtrakAnton JoeGarden City WindIndependent LeagueLas Vegas Train RobbersPecos LeagueSanta Fe FuegoSouthwest ChiefTrinidad Triggers Prized Cuban Yoan Moncada Becomes MLB Free Agent Minnesota Twins’ Kohl Stewart Prepares For Season By Throwing Football Anton is an Independent League Baseball Writer for Baseball Essential. He is also a member of the Internet Baseball Writers Association of America (IBWAA) and is always looking for new baseball minds to meet and talk baseball with. You can follow him on Twitter @AntonJoe_BBE. Jonathan Albaladejo is hopeful he can return to MLB soon Bluefish sweep day/night doubleheader against the Riversharks Bridgeport Bluefish sign catcher Jobduan Morales Christian Carmouche Continues to Chase Dreams Despite His Family’s Disapproval The Angels Should Trade for Luis Castillo David Bednar, the Padres' Gem Hidden in the 35th Round Sadly, There's No Photo of the First High-Five No One Has Been a Hall of Famer Longer Than Sandy Koufax Minnesota Twins Should Focus on Adding Positional Versatility Can the Tampa Bay Rays Successfully Retool - Again? Locked On Dodgers: An Interview with New Dodger Reliever Tommy Kahnle Locked On Dodgers: An Interview with Dodgers Prospect Zach Reks Retired Numbers: Chicago White Sox Copyright 2013-2018 Baseball Essential.	cc/2021-04/en_middle_0086.json.gz/line1797006
__label__wiki	0.612631	0.612631	Café owners Marc and Kim Dufort pose with kindness ambassador Marrou Lamaniere. A Kinder Cup was created with the vision to promote inclusivity and connection. (Nina Grossman/News Staff) Esquimalt cafe cooks up connections for all abilities A Kinder Cup focuses on positivity, inclusivity and connection The steaming chai lattés, Americanos and fresh baked goods at new View Royal Cafe are made with a little extra love and a dose of kindness. A Kinder Cup was born from the mind of Victoria entrepreneur Kim Dufort, who, after more than 15 years working with adults with disabilities and a decade in business, wanted to combine her passions. After coming across a video on Facebook about a business that employed adults with disabilities, she decided to create something similar in Victoria with her business partner and husband, Marc. “Our mission is to promote kindness,” Dufort said. “Kindness to the community, kindness to ourselves…treating our customers with kindness…kindness to the environment.” READ ALSO: Victoria woman hopes to open city’s first cat cafe A Kinder Cup opened in December 2018 in the Admirals Shopping Centre. The quaint café serves up dozens of specialty drinks, sandwiches and baked goods – but best of all, creates a welcoming, inclusive space for employees and customers. “Coffee shops are the new community centres,” Dufort said, waving to an elderly man who walked in the door. “I was looking for a space where the community could come together [and] get to know people with disabilities as people they would like to connect with.” A Kinder Cup employees six ‘kindness ambassadors’ – adults with disabilities – and seven kindness mentors, employees who help the ambassadors navigate the job and often, life. Some of the ambassadors like to work up front, dealing with customers, while others prefer baking or washing dishes in the back. Either way, Dufort says her employees get a lot out of the job. “They love coming to work. They tell me that all the time,” she said with a laugh. “They get to connect with other human beings in a really positive way. They get to serve, which they really enjoy doing because a lot of times, they have other people providing for them.” READ ALSO: Photography-themed cafe opens in downtown Victoria All of the café’s packaging is compostable and environmentally-friendly, an extension of Dufort’s efforts to create a business that leaves only a positive impact in the community. “There’s a lot of negativity out there,” said Dufort. “What can I do here in my little corner of Victoria? And I thought, ‘I can promote kindness.’ Sometimes that’s all it takes. One person to start feeding [positivity] and start diminishing some of that negativity.” nina.grossman@blackpress.caFollow us on Instagram Best Buy sees growth in health care technology for elderly A company that sells toilet odour-eliminating sprays tackles cannabis Mayor Colin Basran says deficit caused by lack of provincial and federal investment; city can't tackle issue alone	cc/2021-04/en_middle_0086.json.gz/line1797008
__label__cc	0.632045	0.367955	Adgestone Vineyard Bed and Breakfast, Cheap Hotel and Guest House Accommodation Adgestone Vineyard Adgestone Vineyard Bed and Breakfasts. Compare latest rates and Live availability for all your favourite places and places you have always wanted to go using our new My Shortlist feature. Click + to add to your Shortlist Bed and Breakfasts near Adgestone Vineyard for 1 night from Wed Jan 20, 2021 to Thu Jan 21, 2021 within 25 miles, in an Average Nightly price range of £1 to £200. Chaston Manor Hotel Sandown 1.1 1.77 4 20212223242526 £140.00 £153.00 £153.00 £140.00 £140.00 £140.00 £140.00 £140.00 The Lawns Sandown 1.14 1.84 N/A 20212223242526 £72.00 £72.00 £72.00 £72.00 £72.00 £72.00 £72.00 £72.00 Marina Bay Hotel Channel View Hotel Sandown 1.49 2.39 2 20212223242526 £45.00 £45.00 £45.00 £45.00 £45.00 £45.00 £45.00 £45.00 Montpelier Bed And Breakfast Sandonw 1.56 2.5 N/A 20212223242526 £25.00 £25.00 £25.00 £25.00 £25.00 £25.00 £25.00 £25.00 The Pilot Boat Inn Bembridge 3.15 5.06 N/A 20212223242526 £90.00 £90.00 £90.00 £90.00 £90.00 £90.00 £90.00 £90.00 Shanklin Beach Hotel Shanklin 3.15 5.07 3 20212223242526 £49.75 £49.75 £49.75 £49.75 £49.75 £49.75 £49.75 £49.75 Richmond Bed & Breakfast Shanklin 3.26 5.24 N/A 20212223242526 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 Victoria Lodge The Nightingale Hotel Shanklin 3.36 5.4 3 20212223242526 £141.75 £141.75 £141.75 £141.75 £141.75 £141.75 £141.75 £141.75 Dorset Hotel, Isle of Wight Ryde 3.75 6.04 3 20212223242526 £67.50 £67.50 £67.50 £67.50 £67.50 £67.50 £67.50 £67.50 Yelf's Hotel Martlets B&B - 2 Ensuite Double Bedrooms Seahaven House No24 Ventnor Ventnor 5.91 9.51 N/A 20212223242526 £85.00 £85.00 £85.00 £85.00 £85.00 £85.00 £85.00 £85.00 The Hambrough Ventnor 6.01 9.67 5 20212223242526 £130.00 £130.00 £130.00 £140.00 £140.00 £130.00 £130.00 £130.00 Newport 6.26 10.07 N/A 20212223242526 £79.00 £79.00 £79.00 £79.00 £79.00 £79.00 £79.00 £79.00 The Wheatsheaf Hotel Old Church House Waverley Inn Newport 7.08 11.39 N/A 20212223242526 £115.00 £80.00 £80.00 £80.00 £80.00 £80.00 £80.00 £115.00 Anglesey Hotel Gosport 7.44 11.98 N/A 20212223242526 £86.85 £86.85 £86.85 £86.85 £86.85 £86.85 £86.85 £86.85 Blue Star House Portsmouth 8.19 13.18 N/A 20212223242526 £39.00 £39.00 £39.00 £39.00 £39.00 £39.00 £39.00 £39.00 Holiday Inn Portsmouth Portsmouth 8.27 13.32 4 20212223242526 £85.00 £85.00 £79.00 £60.72 £60.72 £62.10 £71.10 £85.00 Fortitude Cottage Portsmouth 8.33 13.4 4 20212223242526 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 £65.00 Acorn Lodge Guest House The Caledon Cowes 8.48 13.65 4 20212223242526 £80.00 £80.00 £80.00 £80.00 £80.00 £80.00 £80.00 £80.00 The Caledon Guest House Cowes 8.5 13.68 N/A 20212223242526 £95.00 £95.00 £95.00 £95.00 £95.00 £95.00 £95.00 £95.00 Everley Guest House Portsmouth 8.5 13.68 N/A 20212223242526 £64.00 £64.00 £64.00 £64.00 £64.00 £64.00 £64.00 £64.00 Portsmouth Budget Hotels Spring Garden Guest House 72 Broadway Sandown, Sandown, PO36 9AA Set in Sandown, 1.2 km from Dinosaur Isle, Chaston Manor Hotel features a garden and a shared lounge. The property is situated 2 km from Isle of Wight...more Set in Sandown, 1.2 km from Dinosaur Isle, Chaston Manor Hotel features a garden and a shared lounge. The property is situated 2 km from Isle of Wight Zoo. Free WiFi is available. At the hotel, every room comes with a wardrobe and a flat-screen TV. The private bathroom is fitted with a shower, free toiletries and a hair dryer. A continental breakfast is served daily at the property. The area is popular for cycling, and bike hire is available at Chaston Manor Hotel. 72 Broadway, Sandown, PO36 9AA Nick & Stella offer you a warm welcome to The Lawns,we have been awarded AA Highly Commended 4 Stars.We are 10 min walk for beach/shops etc. We are a ...more Nick & Stella offer you a warm welcome to The Lawns,we have been awarded AA Highly Commended 4 Stars.We are 10 min walk for beach/shops etc. We are a fully licensed family run,which is completely NON-SMOKING,in the popular resort of Sandown,Isle of Wight. 17 Culver Parade, Sandown, PO36 8AT Located in Sandown, Marina Bay Hotel offers a terrace and free WiFi. This property is set a short distance from attractions such as Dinosaur Isle and ...more Located in Sandown, Marina Bay Hotel offers a terrace and free WiFi. This property is set a short distance from attractions such as Dinosaur Isle and Isle of Wight Zoo. Guests can have a drink at the bar. The units in the hotel are fitted with a flat-screen TV. With a private bathroom, some units at Marina Bay Hotel also feature a sea view. All units will provide guests with a desk and a kettle. 4-8 Royal Street, Sandown, PO36 8LP A 4-minute walk from the beach and Sandown Pier, Channel View Hotel includes a restaurant and bar and provides free parking and WiFi. This hotel is ju...more A 4-minute walk from the beach and Sandown Pier, Channel View Hotel includes a restaurant and bar and provides free parking and WiFi. This hotel is just over 1 mile from the Isle of Wight Zoo. Each room has a TV, wardrobe and tea and coffee facilities. All have an en suite shower with a hairdryer and toiletries. The hotel bar is open all day and has an outdoor terrace. There is also regular live entertainment. Channel View Hotel is around 6 minutes' drive from the Shanklin & Sandown Golf Club and 10 minutes from the Shanklin Chine. Bembridge Windmill is just under 5 miles away and the coastal town of Ventnor is around 7 miles from Sandown. Pier Street, Sandonw, PO36 8JR Situated in one of the finest positions in Sandown across the road from the pier and beach and around the corner from the High Street. We offer room o...more Situated in one of the finest positions in Sandown across the road from the pier and beach and around the corner from the High Street. We offer room only, B&B and ferry inclusive. Rooms are ensuite shower and most have sea views. Station Road, Bembridge, PO35 5NN Located in Bembridge, The Pilot Boat Inn features a terrace. The property features a bar, as well as a restaurant serving Grill Bbq cuisine. Free WiFi...more Located in Bembridge, The Pilot Boat Inn features a terrace. The property features a bar, as well as a restaurant serving Grill Bbq cuisine. Free WiFi is provided. All rooms in the inn are fitted with a kettle. The private bathroom is equipped with a shower, free toiletries and a hair dryer. Guests at The Pilot Boat Inn can enjoy a continental breakfast. You can play darts at the accommodation. Shanklin is 13 km from The Pilot Boat Inn. The Esplanade, Shanklin, PO37 6BJ Located on Shanklin's seafront, Shanklin Beach Hotel offers panoramic views of the English Channel. With its own restaurant and bar, it also includes ...more Located on Shanklin's seafront, Shanklin Beach Hotel offers panoramic views of the English Channel. With its own restaurant and bar, it also includes free WiFi in public areas and free on-site parking. The contemporary rooms at Shanklin Beach Hotel each feature a TV with satellite channels, an en suite bathroom, a hairdryer and a work desk. Inside the spacious restaurant, both a breakfast and a dinner menu are available. Whilst dining, guests can enjoy views of the esplanade. The Beach Bar offers a selection of beers, wines and spirits. A vibrant bar, it has live entertainment on most evenings. From the property, Shanklin Chine is 7 minutes' walk away. Shanklin Theatre and the Old Village are both also a 13-minute stroll away. Shanklin Train Station is less than a mile away. 23 Palmerston Road, Shanklin, PO37 6AS We are within minutes walking distance of the beach, the old village, restaurants and pubs some overlooking the sea. We aim to make your stay one that...more We are within minutes walking distance of the beach, the old village, restaurants and pubs some overlooking the sea. We aim to make your stay one that you will want to repeat. Free wifi and car parking available as are discounted ferry prices. 5 Alexandra Road, Shanklin, PO37 6AF Victoria Lodge Hotel is set in Shanklin, just a 7-minute walk from the beach. Guests can enjoy the on-site bar, which is open till midnight. Free priv...more Victoria Lodge Hotel is set in Shanklin, just a 7-minute walk from the beach. Guests can enjoy the on-site bar, which is open till midnight. Free private parking is available on site. Victoria Lodge Hotel features free WiFi. Each room is en-suite and has a flat-screen TV. There is a shared lounge at the property. The building has a glass front to enjoy views across the bay. Discounted ferry travel is available upon request. The nearest airport is Southampton Airport, 63.7 km from Victoria Lodge Hotel. 3 queen's road, Shanklin, PO37 6AN Located in Shanklin, The Nightingale Hotel features a 24-hour front desk and a shared lounge, along with free WiFi throughout the property. Guests can...more Located in Shanklin, The Nightingale Hotel features a 24-hour front desk and a shared lounge, along with free WiFi throughout the property. Guests can enjoy European dishes at the restaurant or have a cocktail at the bar. At the hotel, every room is equipped with a desk, a flat-screen TV and a private bathroom. The Nightingale Hotel offers certain units with sea views, and rooms include a kettle. All rooms include a wardrobe. A cooked and continental breakfast is served every morning at the property. A buffet is served on Mondays and Tuesdays. This Gothic decorated hotel, offers a seasonal outdoor pool, and the area is popular for cycling. Casino nights are also hosted at the property. The Castle Game room has a billiards table, an arcade game and dart board. Guests can make sightseeing and ticketing arrangements at the tour desk, or conduct business at the business centre. Sandown is 3.2 km from the hotel, while Ryde is 11 km away. 31 Dover Street, Ryde, PO33 2BW Centrally located in Ryde on the Isle of Wight, Dorset House is just an 8-minute walk from 6 miles of sandy beaches. The hotel features a large car pa...more Centrally located in Ryde on the Isle of Wight, Dorset House is just an 8-minute walk from 6 miles of sandy beaches. The hotel features a large car park, available to all guests for free. Guests can enjoy the bar and lounge. There is free WiFi throughout the property. Bedrooms at Dorset Hotel, Isle of Wight are individually decorated and they all feature tea/coffee making facilities, a Freeview TV. Some offer sea views across the Solent. Guests can make use of laptops, provided by Dorset House. There is also a garden for guests to enjoy. This bed and breakfast is just 300 yards from the Seafront Esplanade and a 3-minute walk from the hovercraft, bus and railway stations. Union Street,, Ryde, PO33 2LG In a popular part of Ryde, Yelf's Hotel is a former coaching inn with a restaurant, close to the hovercraft and ferry services to Portsmouth and South...more In a popular part of Ryde, Yelf's Hotel is a former coaching inn with a restaurant, close to the hovercraft and ferry services to Portsmouth and Southsea. Yelf's Hotel is one of the oldest coaching inns on the Isle Of Wight. There is a comfortable bar and lounge area with a conservatory and patio. Newport and Cowes are both a 15-minute drive from Ryde, and Yelf's is a few minutes from the sea. Martlets, 24A Church Road, Shanklin, PO37 6QY Martlets is a newly built traditional home on the outskirts of Shanklin Old Village in a quiet countryside setting and within reach of the town beach ...more Martlets is a newly built traditional home on the outskirts of Shanklin Old Village in a quiet countryside setting and within reach of the town beach and country walks, offering quality BandB. 35-36 St Thomas Street, Ryde (Isle of Wight), Ryde, PO33 2DL Opposite Ryde Pier on the Isle of Wight, this Victorian guest house has beautiful sea views and is a few metres from Western Beach. Bedrooms have an e...more Opposite Ryde Pier on the Isle of Wight, this Victorian guest house has beautiful sea views and is a few metres from Western Beach. Bedrooms have an en suite bathroom, a TV and free Wi-Fi access. Seahaven House is a 5-minute walk from the ferry/hovercraft and catamaran foot passenger services. Bars, restaurants, pubs and shops of Ryde are just a 200-metre walk from Seahaven House. 24 High Street, Ventnor, PO38 1RZ Situated in Ventnor, No24 Ventnor has a garden and a shared lounge. All rooms feature a flat-screen TV with satellite channels and a private bathroom....more Situated in Ventnor, No24 Ventnor has a garden and a shared lounge. All rooms feature a flat-screen TV with satellite channels and a private bathroom. Free WiFi is available. All rooms in the hotel are equipped with a kettle. The units include a desk. A continental breakfast is served each morning at the property. Shanklin is 6 km from No24 Ventnor, while Sandown is 10 km from the property. Hambrough Road, Ventnor, PO38 1SQ Siting high above Ventnor Fishing Harbour on the southern tip of the Isle of Wight, The Hambrough offers boutique accommodation overlooking the sea, j...more Siting high above Ventnor Fishing Harbour on the southern tip of the Isle of Wight, The Hambrough offers boutique accommodation overlooking the sea, just 5 minutes' walk away from Ventnor beach and 5 minutes' drive from the famous Ventnor Botanic Gardens. Bedrooms have comfy beds, espresso machines and flat-screen TVs with satellite and a DVD/CD player. Bathrooms come with Molton Brown toiletries and all but one room has magnificent sea views. Guests can enjoy a hearty breakfast each morning. The sheltered location on the cliff of the Island's south coast means the area experiences more sunshine than much of the British Isles. The property is a 5-minute walk of Ventnor town centre. 14A Saint Thomas' Square, Newport, PO30 1SL Set in Newport, 2.5 km from Carisbrooke Castle, Charter House offers air-conditioned accommodation and a bar. The property is situated 4.3 km from Rob...more Set in Newport, 2.5 km from Carisbrooke Castle, Charter House offers air-conditioned accommodation and a bar. The property is situated 4.3 km from Robin Hill. Free WiFi and room service are provided. All units in the hotel are fitted with a kettle. Every room is fitted with a private bathroom. The daily breakfast offers continental, Full English/Irish or vegetarian options. Charter House offers a sun terrace. 16 Saint Thomas Square, Newport, Newport, PO30 1SG Originally a coaching inn dating back to the 17th century, The Wheatsheaf Hotel is situated in the centre of Newport on the Isle Of Wight. It boasts o...more Originally a coaching inn dating back to the 17th century, The Wheatsheaf Hotel is situated in the centre of Newport on the Isle Of Wight. It boasts original features and a traditional dining experience for breakfast, lunch and dinner. This English pub and hotel has home-cooked treats, local ales, beers and wines. Situated in Saint Thomas Square in the heart of Newport, there are adjacent cafÃ© bars, shops and pubs. The property is a 2-minute walk to central public transport links and a 10-minute drive to the passenger and car ferry ports to both Southampton and Portsmouth. The coastal towns of Ryde, Cowes, Yarmouth and Ventnor are within a 20-minute drive. 46 Crocker Street, Newport, PO30 5DB Situated within 1.8 km of Carisbrooke Castle in Newport, Old Church House provides accommodation with free WiFi. A flat-screen TV and DVD player are a...more Situated within 1.8 km of Carisbrooke Castle in Newport, Old Church House provides accommodation with free WiFi. A flat-screen TV and DVD player are available in some units. The daily breakfast offers continental, Full English/Irish or vegetarian options. Guests can also relax in the shared lounge area. Robin Hill is 5 km from the bed and breakfast. 2, Clatterford Road, Carisbrooke, Newport , Isle of wight, Newport, PO30 1PA Featuring free WiFi and a restaurant, Waverley Inn is a Victorian era pub build around 1886 which offers pet-friendly accommodation 10-15 minutes' wal...more Featuring free WiFi and a restaurant, Waverley Inn is a Victorian era pub build around 1886 which offers pet-friendly accommodation 10-15 minutes' walk from Newport. Free private parking is available on site. The rooms come with a TV and a kettle. Breakfast is available in the morning from 08:00. Guests can enjoy the on-site bar which offers live music every Saturday evening from local musicians. Carisbrooke Castle is 1.9 km from Waverley Inn, while Robin Hill is 5 km from the property. The nearest airport is Southampton Airport, 29 km from Waverley Inn. 24 Crescent Road Alverstoke, Gosport, PO12 2DH Anglesey Hotel is situated in Gosport. Among the various facilities of this property are a garden and a bar. Free WiFi is at guests' disposal. At the ...more Anglesey Hotel is situated in Gosport. Among the various facilities of this property are a garden and a bar. Free WiFi is at guests' disposal. At the hotel, each room comes with a desk. Rooms are fitted with a private bathroom with free toiletries. Guest rooms in Anglesey Hotel are fitted with a flat-screen TV and a hair dryer. Guests at the accommodation can enjoy a Full English/Irish breakfast. There is an in-house restaurant, which serves British cuisine and also offers gluten-free options. Southampton is 31 km from Anglesey Hotel. The nearest airport is Southampton Airport, 33 km from the property. 20 Elphinstone Road, Portsmouth, PO5 3HR Blue Star House offers accommodation in the centre of Southsea, Portsmouth. Every room has a flat-screen TV. You will find free toiletries and a haird...more Blue Star House offers accommodation in the centre of Southsea, Portsmouth. Every room has a flat-screen TV. You will find free toiletries and a hairdryer. Blue Star House offers free WiFi throughout the property. There is a shared kitchen with tea/coffee making facilities. Mary Rose Museum is 2.7 km from Blue Star House, while Port Solent is 9.6 km from the property. The nearest airport is Southampton Airport, 34.6 km from the property. Pembroke Road, Portsmouth, PO1 2TA Located by the sea front, the Holiday Inn Portsmouth offers a lobby, a bar and a restaurant. Guests can also access the on-site Spirit Health Club wit...more Located by the sea front, the Holiday Inn Portsmouth offers a lobby, a bar and a restaurant. Guests can also access the on-site Spirit Health Club with a swimming pool, gym, hot tub, steam room and sauna. Free WiFi is available throughout the property and parking is available for a fee. Each room at this Holiday Inn features a flat-screen TV, tea/coffee making facilities, and air conditioning. The historic Dockyard, where guests can discover HMS Victory, HMS Warrior, and the Mary Rose, is a 15-minute walk away. Gunwharf Quays leisure and shopping complex, featuring over 90 shops, a wide selection of bars and restaurants, bowling, cinema, and stunning views of Portsmouth, Isle of Wight and the Solent, is a 10-minute walk from the hotel. The continental ferry port, cruise terminal and Isle of Wight ferry are 1 mile away and Southampton Airport is less than 30 minutes' drive from the hotel. 51, Broad Street,, Spice Island,, Portsmouth, PO1 2JD Location, Location, Location. We are situated 50 steps from the waters edge with the Historic Dockyard, Gunwharf Quays and all attractions within walk...more Location, Location, Location. We are situated 50 steps from the waters edge with the Historic Dockyard, Gunwharf Quays and all attractions within walking distance. We have a penthouse room with views that can&#39t be bought anywhere else. WE CARE !! 3 Spring Garden Lane, Gosport, PO12 1HY In the centre of Gosport, this hotel offers free Wi-Fi and free parking. Set just 0.5 miles from the bustling harbour front, there are restaurants wit...more In the centre of Gosport, this hotel offers free Wi-Fi and free parking. Set just 0.5 miles from the bustling harbour front, there are restaurants within a few hundred metres. Acorn Lodge Guest House Gosport's spacious rooms each have a TV, tea/coffee making facilities and an in-room toilet, basin and towels. Shared bathroom facilities are also provided for guests, and hairdryers and irons are available on request. Whilst Acorn Lodge doesn't offer food or breakfasts, there is a cafÃ© opposite the property. The beach at Averstoke and stokes bay sailing club is less than a 4 minutes drive away. The beach at Lee-on-the-Solent is less than a 10-minute drive away. Gosport ferry terminal is a 10-minute walk from the Lodge, providing regular 5-minute ferry services to Portsmouth's historic harbour. Within a few minutes' walk guests can find bars and shops, and a town bus route. 59 Mill Hill Road, Cowes, PO31 7EG We offer the perfect mix of a friendly, welcoming bed and breakfast with the spacious, non intrusive feel of a small hotel in the beautiful Cowes on t...more We offer the perfect mix of a friendly, welcoming bed and breakfast with the spacious, non intrusive feel of a small hotel in the beautiful Cowes on the Isle of Wight We have free parking, wifi and are VAT registered Situated in Cowes on the Isle of Wight, The Caledon Guest House boasts free Wi-Fi and free private parking. This family run Victorian house is just 5 ...more Situated in Cowes on the Isle of Wight, The Caledon Guest House boasts free Wi-Fi and free private parking. This family run Victorian house is just 5 minutes' walk from the bustling town centre. The modern rooms feature a flat-screen Freeview TV with a DVD player, a hairdryer, and Fairtrade tea and coffee making facilities. The en suite or shared shower rooms benefit from bathrobes. In the mornings, The Caledon serves an extensive breakfast menu, with full English breakfast and smoked salmon options. Dishes are cooked to order and prepared using fresh, locally sourced produce. Cowes' lively pubs, great restaurants, and individual shops are just 5 minutes' walk away. Cowes offers ferry links to and from Southampton. The seaport town is well known for its sailing clubs and marinas. Ideal for cycling and walking, it is the start of the Isle of Wight Coastal Path. There are several sandy beaches within a 1 mile radius of The Caledon Guest House. 33 Festing Road, Southsea, Portsmouth, PO4 0NG Everley Guest House is situated in Portsmouth, 3.9 km from Mary Rose Museum. The property is set 10 km from Port Solent, 2.1 km from Spitbank Fort and...more Everley Guest House is situated in Portsmouth, 3.9 km from Mary Rose Museum. The property is set 10 km from Port Solent, 2.1 km from Spitbank Fort and 3.2 km from Portsmouth Cathedral. The property is 3.4 km from HMS Warrior. At the guest house, all rooms have a wardrobe, a flat-screen TV and a private bathroom. HMS Victory is 3.5 km from Everley Guest House, while National Museum of the Royal Navy is 3.5 km from the property. Southampton Airport is 35 km away. 20 b Landport Terrace, Portsmouth, PO1 2RG Providing free WiFi, Portsmouth Budget Hotels is set in Portsmouth, within 2.2 km of Mary Rose Museum. Built in 1940, the property is within 9 km of P...more Providing free WiFi, Portsmouth Budget Hotels is set in Portsmouth, within 2.2 km of Mary Rose Museum. Built in 1940, the property is within 9 km of Port Solent and 1.2 km of Portsmouth Cathedral. The property is situated 1.4 km from HMS Warrior. All the guest rooms in the guest house are equipped with a flat-screen TV and en-suite bathroom is fitted with a shower. HMS Victory is 1.5 km from Portsmouth Budget Hotels, while National Museum of the Royal Navy is 1.5 km away. The nearest airport is Southampton Airport, 33 km from the property. Spring Garden Guest House Spring Garden Lane, Gosport, PO12 1LP Spring Garden Guest House is located in Gosport, 23 km from Southampton and 2.6 km from Portsmouth. Guests can enjoy the on-site bar. The property is ...more Spring Garden Guest House is located in Gosport, 23 km from Southampton and 2.6 km from Portsmouth. Guests can enjoy the on-site bar. The property is within walking distance to the passenger ferry to Portsmouth. All rooms include a TV. You will find tea and coffee making facilities in the room. Rooms are fitted with a private bathroom. You will find a shared lounge at the property and free WiFi is available. Winchester is 32 km from Spring Garden Guest House, while Chichester is 25 km away. The nearest airport is Southampton Airport, 23 km from the property.	cc/2021-04/en_middle_0086.json.gz/line1797011
__label__wiki	0.906312	0.906312	Choose an issue Spread the wordShare this page as an infographic For millions of people, working in agriculture means poverty, child labor, dangerous conditions and the constant uncertainty that comes with casual work. So the Behind the Brands Scorecard examines what companies say they are doing to ensure the rights of farm workers, including by tackling low pay, poor and unsafe working conditions, and child exploitation. How are the scores formed? We assessed publicly available information on the policies and commitments of the 'Big 10' food companies towards the sourcing of agricultural commodities from developing countries. The Scorecard looks at seven themes, weighing each theme equally. The index tackles some cutting edge issues that will require rigorous debate and dialogue between companies, civil society and industry experts. Find out more... What do the scores mean? 8 - 10Good 6 - 7Fair 4 - 5Some progress 2 - 3Poor 0 - 1Very poor Unilever is a leader when it comes to workers. Unilever’s Responsible Sourcing Policy sets out new requirements for its suppliers in relation to workers’ rights. It could still improve on ensuring its suppliers implement key labour rights, and like the others, it needs to do much more to ensure workers are paid a living wage. See how Unilever score on other issues Coca-Cola’s policies towards workers are, quite strong in many places, but to have a real impact, the company needs to commit to a living wage for all workers in their supply chain. See how Coca Cola score on other issues Nestle scores highly on workers rights, but the company could do much more to ensure workers in its supply chain are able to work their way out of poverty. Nestle should start recording the wages that workers are paid so that they can be compared to living wage benchmarks. The company should also develop a strategy for raising low wages. See how Nestlé score on other issues Associated British Foods plc ABF now recognizes a range of key workers’ rights and unlike many companies on the scorecard , has made an explicit commitment to a Living Wage. However, ABF should now develop a strategy to raise low wages. See how Associated British Foods plc score on other issues Mars shows some general understanding of issues faced by workers and has made a new commitment on the United Nations Guiding Principles on Business and Human Rights. However, like many of the Big Ten, it has limited specific information about workers throughout its supply chain and does not commit to pay workers a living wage. See how Mars score on other issues Mondelez has steadily moved up in score on workers but the company has still not committed to living wages nor established a constructive and ongoing dialogue with the union representing workers in its supply chains. See how Mondelez score on other issues A disappointing lack of information means Danone, which has signed up to international labor conventions, doesn’t actually know how many people are in its supply chains. Its recent agreement with the main union for food and agriculture workers globally is a solid step in the right direction. See how Danone score on other issues General Mills has a slow but steady improvement on worker issues. The company still needs to establish a constructive and ongoing dialogue with its workers’ union. See how General Mills score on other issues There is a slow but steady improvement from Kellogg on worker issues. The company would go a long way by establishing a constructive and ongoing dialogue with the union who represents workers in its supply chain. See how Kellogg's score on other issues PepsiCo has work to do to improve workers’ rights. The company does not appear to have a system for identifying high-risk countries for forced labor or low wages. PepsiCo needs to know where labor rights risks are to manage them effectively. See how PepsiCo score on other issues Make noise, make change The companies who make your favourite brands listen to you. They care what you think. You can change the way they do business. You have power. If you share this this page through your social networks it will be noticed and will encourage brands and their parent companies to act. Share this infographic on Twitter Share this infographic on Facebook Pin this infographic on Pinterest Download this infographic as an image	cc/2021-04/en_middle_0086.json.gz/line1797013
__label__cc	0.707448	0.292552	Cheley Tackett Interview October 18, 2018 Nick Cantwell There’s so many ways to discover artists and music these days, largely due to the growth of social media, and I have to thank a random comment on an Ashley McBryde fan page for coming across Ohio born Cheley Tackett. The pair are friends and frequent collaborators, so of course I had to give Cheley’s music a listen ( incredible!) and check out her tour dates ( even more incredible as she was set to play a house concert a few miles from me that week!) . It would have been rude not to make that 20 minute drive and seeing her in such an intimate setting was something very special. Playing songs from her recent release “ Buckeye “ and back catalogue she told us some of the stories behind her writing ( often hilarious, sometimes poignant, always interesting) and her rich, powerful and emotional vocals were even better than on her recordings. Cheley has one more UK gig before returning home to Nashville, tonight ( Oct 18th) she plays Ealing, West London. For further information, links to her socials and details of where to stream/download her music go to cheleytackett.com We had a long chat after her set, and of course that included me asking if she’d answer some questions for this site …….hope you enjoy her interesting answers! 1. LH Hello Cheley, I gather you’re still in the UK as you’re answering these questions but exactly where are you right now? CT In Brighton right now. Then have a few days off to explore London & am playing final gig on this run at Westfield House in South Ealing Thursday night. 2. LH Sorry but I’ve only recently come across your music, not sure why especially as you seem to visit us pretty regularly! What is it you like about playing to a UK audience? CT UK audiences seem more attentive than US audiences & I think lyrics seem to matter more here which may lend to the attentiveness as you have to pay attention to catch the words. 3. LH Taking things back to your Ohio days, how did you get your musical education and which artists were you listening to there that you and made you want to write/perform? I’m picking up quite a variety of influences in your music… CT My dad bought my mom a guitar but it sat in the closet & didn’t see much daylight. They said around five years old I started dragging it out and trying to use the couch to leverage & hold it and then sang every song I’d ever heard to an open strum. When I finally got old enough to actually hold it, around age 10, they put me into guitar lessons. As far as influences go, they’re varied but Jerry Reed was my first concert. I grew up watching & listening to HeeHaw & Pop Goes the Country. I remember a good bit of Kenny Rogers & Barbara Mandrell as well as the outlaws & Johnny Cash being played but Mom also had lots of the Beatles music & some Pop Top 40. As I got a little older, I gravitated to the country female altos like Kathy Mattea, Wynonna, & Mary Chapin Carpenter (aside from the lack of women in country music, where the hell have all the altos gone?). I listened to a good bit of rock too, U2, Springsteen, Tom Petty, etc. I’ve joked that if Tom Petty & Mary Chapin Carpenter had a baby, it might sound like my latest album Buckeye. 4.LH When did you decide to relocate to Nashville……did you know anyone there and how welcoming did you find the songwriting community initially? CT I think I always knew I was going to land in Nashville. I’m pretty sure my parents weren’t surprised much that I moved there eventually but we had an agreement that I would finish college & get my degree before I moved there, and so I did. I found the songwriting community to be extremely welcoming & the best way to network the music industry itself. They were much more accessible, even the hit writers, than other facets of the industry. 5. LH Co-writing is a huge part of the Nashville music scene isn’t it, do you feel pressure going into a writing session to achieve something every time or do you just relax and have fun, with a song at the end of the day being a bonus? CT When I was new I felt pressure, and there is certainly some pressure on paid staff writers as they contractually have an annual quota, but I’ve learned that you have to stay true to the song and some songs need more time to breathe. The other thing I’ve learned though is that co-writing tends to jumpstart me some as a solo writer as well. So, if I’m in a rut trying to write on my own, I book more co-writes to get my writing brain working better. 6. LH Are there any particular co-writers you generally always tend to click with ….and anyone you’d like to collaborate with in the future? CT There are a few repeat names on my latest album as well as on albums I’ve put out before. Nicole Witt (from Farewell Angelina) & I met very shortly after we both moved to Nashville. We’ve just always really clicked. She’s also a hell of a singer & musician and has been on every single album I’ve put out in some capacity. Lisa Carver and I are old friends & write well together but interestingly enough have always written better with a third person in the room. Same holds true for my buddy Ashley McBryde. Rob Wolf, Randall Clay, Mark Stephen Jones, Blue Foley, all great co-writers that helped bring out the best in me. As far as who I’d like to get in a room with? I’m itchin’ to get in a room with Travis Meadows. We’ve been friends for awhile now but haven’t seemed to manage to get a date nailed down when we’re both in town. Lori McKenna, Erin Enderlin, & Brandy Clark are some gals I haven’t written with yet that I’d like to. 7. LH Yet one of my favourite songs of yours, “ Good For Me” was a solo write that took just 30 minutes I gather! I guess some very personal experiences can result in outpourings like this? CT The speed I wrote that one in surprised me. I never even edited it. I perform it exactly as it showed up in the world. You just never know. “Jerusalem Ridge,” which is another solo write, took me almost a year. I had the first two verses written for months w/o knowing what the hook was or the melody for the chorus. Like I said, some songs need more time to breathe. 8 LH. Can I ask you about your most recent release, “ Buckeye” . Were all the songs written especially for this album, or were any of them from a while back, just waiting for the right place to land? CT No, none of them were written specifically for this album. I had a collection of songs that I felt sat with each other and realized as I was looking towards recording that they all had threads of Ohio running through them that tied them together. Some more subtle than others but even $2 Bill which I’ve had for some time now but just didn’t make sense for other projects, seemed a natural fit for this record. 9. LH Do you have a favourite from it to perform live ( with or without a band!) and is there maybe one that’s getting particularly good feedback ( I’m especially fond of the dark “ My Best Dress” and the uplifting closing track “ Magic Still Happens”! ) CT I love rocking out on All She Knows is Rain but I’m getting the best response on $2 Bill, The Healer, My Best Dress, Used to Feel Good, & Magic Still Happens. 10 .LH When we met we talked about the uphill struggle facing female country artists these days to get radio play ( you looked back at some stats over the past few decades didn’t you?) and headline slots at festivals. It really is tough out there now isn’t it? How disheartening and frustrating is it for you and your contemporaries ? And can you see a way out of this any time soon? CT It’s incredibly frustrating especially when I know some of the best music is being made by women but country radio’s not playing them so nobody’s hearing them. Also, we’ve been seeing less & less females on the charts & in the festivals for years now. It’s been a steady decline for decades. Somethings got to give. I’m not sure what exactly that is but I think it’s going to require more women in positions of power in radio, A&R, publishing, promotion, management, and in executive positions at the labels. The whole industry has disproportionate representation. I think women should start buying radio stations. I also think an all women festival or touring festival (think a country version of Lilith Fair) might be a good idea too to prove that female artists have a draw & can sell tickets. 11 LH What does the remainder of 2018 and early 2019 hold in store for you? CT The remainder of 2018 has me writing more and touring in the US. March 2019 finds me back in the UK with dates in Liverpool, Bewdley, Colchester, Brighton, and more still to be added. Interview conducted by Lesley Hastings (twitter.com/lesleyhastings) ← Social Media Choice – Sunny Sweeney’s ‘Bottle By My Bed’ Liv Austen’s ‘A Moment of Your Time’ Review → Halle Kearns – ‘Pick Me Up’ Review July 25, 2020 Craig Brooks Comments Off on Halle Kearns – ‘Pick Me Up’ Review Interview with Jessica Clemmons of Jess and the Bandits! October 3, 2018 Nick Cantwell Comments Off on Interview with Jessica Clemmons of Jess and the Bandits! Interview with Caryn Lee Carter September 19, 2017 Nick Cantwell Comments Off on Interview with Caryn Lee Carter	cc/2021-04/en_middle_0086.json.gz/line1797015
__label__cc	0.608798	0.391202	Category: abstract art November 11, 2020 Hannah As various as cultures and folks of the world are, so are types of photography. In any case the description of those footage by many individuals who view them is ‘beautiful, natural and dazzling’. Discover out extra about digital cameras from the comprehensive guide provided under. Acceptance constraints on photographers had been step by step stripped away when museums and art schools embraced photography as a professional type of artwork; the development still exists as we speak. The atypical snapshots, physique images, anthropological photographs, medical pictures, film stills, and even police pictures are manipulated to create the impression of surrealist pictures in the pictures. In case you’re a beginner, you needn’t be intimidated, because there are many articles that specify the basics of taking footage. Each aspects of struggle photography are as intently debated at this time, as they were when Mathew Brady photographed the American Civil Battle. Within the decade of the 1960’s, photography had made important inroads to the world of visible arts. Compact thirty-five millimeter cameras and fast film gave combat photographers choices their forbearers may by no means think about. Then digicam was invented producing black and white photographs. Roger Fenton was the primary photographer to capture images of a serious conflict throughout the Crimean War of 1853. Individuals can identify many well-known artists, however there are few photographer’s whose artwork is recognized beyond the scope of their community of fellow photographers. Surrealism in photography was one of the main revolutionary changes in the evolution of photography. But, when surrealism comes to photography, the critics didn’t even think about such a possibility. The images produced by the flush of sunshine can create wonderful images that has a surrealistic look. An novice photographer, McCosh recorded images of the Sikh Warfare in 1848 and the Second Burma Battle of 1852. Kindly note that this photography is purely creative and has nothing to do with pornography. Photos can be uploaded to a computer and pasted to articles or electronic mail messages so they can be sent to others world wide. There are so many forms of digital cameras out there, that narrowing down on one can be extremely perplexing. Met Artwork Photography Info on the most well-known photographers in historical past of photography. By the beginning of the First World Battle, photography had made nice strides. Though military censorship was still in place, images from the Second World Battle had been used successfully to control both patriotism and outrage. The view of photography as an artwork form had little recognition in its infancy. From coloured image making the digital photography made its appearance on this planet. Digital photography uses three filter layers for an image. In some photographs, he captures the wonder and ease of science, and in others, he creates worlds that are enjoyable and imaginative, through which he then hides objects for individuals to search out. Photography is an artwork of creating shifting or nonetheless pictures by recording radiation on a delicate medium similar to a … Visual Arts Contest November 7, 2020 Hannah Columbia offers an abundant array of visual arts educational programs and sources, drawing on its exceptional college and its presence in New York Metropolis. Kristi Groberg,Ph.D offered the analysis paper “The Evil Eye: Satanic Representations of Andrei Belyi in the Visual Arts” on the Association Canadienne des Slavistes Conference, Calgary, Canada, 2016), in Could 2016. Media reminiscent of drawing, portray, sculpture and printmaking continued to thrive on the planet even as newer types—including pictures, graphic design and sound design—rose to prominence. We’re creatively diverse, professionally active artists who share a common imaginative and prescient: we are deeply invested in helping you reach your creative and tutorial potential. The Visible Arts department presents quite a lot of superbly illustrated catalogues that chronicle previous Americas Society exhibitions. The course will emphasize how students can use 16mm know-how in direction of successful cinematography and picture design (to be used in each analog and digital postproduction eventualities) and learn how to develop their ideas in direction of developing which means via shifting photos. The Theatre Program at A&T was the first accredited Bachelor of Fantastic Arts (BFA) at an HBCU in North Carolina; second in the nation. Novice and professional artists are encouraged to use. In addition to the 2 prerequisite courses listed above, a total of 12 credits in visible arts studio programs are required. Artwork, Advantageous Artwork, Arts Group The visual art movement generally known as Pop Art began in Britain through the middle of the Nineteen Fifties. Other requires programs might include Introduction to Painting, Introduction to Images, Ceramics, 2D Design, 3D Design, Introduction to Computer Based Artwork, Figure Drawing, Water Shade, Sculpture I, Introduction to Images, and Black and White Images. Through learning the vary of digital and mechanical instruments that have sought to couple the senses – from nineteenth century coloration organs and goals of synesthesia, via music movies and modern new media installations, to latest advances in “machine listening” – college students will complete a sequence of essential essays and sketches leading in the direction of a last undertaking utilizing customized software program developed in and for the class. Colour In Visual Art Visual Arts at Bowdoin provide college students with a greater capability for artistic inquiry and fingers-on engagement by means of direct remark of the world. Shows art work from artists with direct ties, past or present, to southeastern South Dakota. He is illustrated 4 books and lots of of cartoons and illustrations fro educational, newspaper, e book, magazines and promoting publications. Visual Art at Wheaton Academy includes the studio disciplines of drawing, portray, ceramics and sculpture as well as media disciplines graphic design, pictures and video. This course is a multidisciplinary intensive into the ways wherein creative production is dependent on and a part of bigger cultural tropes. The Visual Arts program at SUNY Previous Westbury focuses on a problem and challenge oriented course of study. Students who elect to main in Visible Arts, Design are required to finish a minimal of 124 semester hours … On-line Philosophy Sources Weekly Update September 22, 2020 Hannah Majors are launched to the central questions and movements within the history of philosophy as a basis for tackling as we speak’s philosophical problems. Philosophy is the systematic study of the foundations of human information with an emphasis on the situations of its validity and finding solutions to final questions. This course companion to the ‘Introduction to Philosophy’ course was written by the Edinburgh Philosophy workforce expressly with the needs of MOOC students in mind. As to the history of philosophy, not solely are very prolonged particular research dedicated to it, but more and more room is given it within the study of each philosophic question. As used initially by the traditional Greeks, the time period “philosophy” meant the pursuit of information for its personal sake, and comprised ALL areas of speculative thought, together with the humanities, sciences and religion. Metaphysics is the study of the character of actuality, together with the relationship between thoughts and physique, substance and accident, occasions and causation, abstract and concrete. In our personal time, subjects resembling consciousness studies, decision principle, and applied ethics have more and more discovered independence from philosophy as a complete. NiccolÃ² Machiavelli (1469-1527) challenged standard concepts about morality Francis Bacon (1561-1626) wrote in favor of the methods of science in philosophical discovery. The restricted interests of many of the philosophers of the time foreshadow the separation and specialization of various areas of philosophy that may occur in the 20th century. The Philosophy curriculum at Earlham is distinctive in its depth of coverage of the historical past of philosophy. On this exercise, philosophers are working on their very own terrain and with their very own purely rational methodology, but extending their analysis to new facets of truth.â€ (Fides et Ratio seventy six) Aware of the Church’s custodianship of the truths of revelation, philosophy on the University understands the organic relationship through which it stands to the Church’s Magisterium. Kant , certainly, is so essential an element within the destinies of contemporary philosophy not solely because he is the initiator of critical formalism, but still more as a result of he obliges his successors to cope with the preliminary and fundamental question of the limits of information However the experimental investigation of psychological processes has turn out to be the thing of a new examine, psycho-physiology, by which males of science co-function with philosophers, and which meets with increasing success. Philosophy Of High Midday Philosophy has been around since time immemorial. This program continues to have one of the most successful placement rates in probably the most competitive doctoral philosophy packages, with students who have continued to doctoral packages at New York College, Princeton College, College of Southern California, University of Notre Dame, Northwestern College, University of Texas at Austin, University of St Andrews and elsewhere. When you instructed somebody you had found an operating system for being a superb human being â€” methods to solve the issues of life, how you can handle our tempers, the place to seek … The Varied “Cartoons” Categories You Can Examine April 4, 2020 Hannah The phrase Anime is an abbreviation of animation. Visual novel characters are often depicted through graphic sprites superimposed upon a generic background; more detailed character designs and backgrounds are usually reserved for key scenes and events within the narrative. Embodying comics: Reinventing comics and animation for a digital performance. Most comedian e book artists will earn an art diploma with an emphasis in drawing or. The brand new Museum would be the icon of a larger growth, the Comedian and Animation Centre. The Dam Keeper is certainly some of the painterly graphic novels we have published, and I am very pleased with it. Dice and Robert made the journey to the comics medium with passion and humility, and the result speaks for itself. David Steward II has been placing assets behind his vision of increasing the marketplace for comics and comedian-associated pop culture to new age teams and demographics because the early 2010s, constructing a portfolio of titles and imprints that characteristic characters and creators from a wide variety of backgrounds. Liu is clearly inspired by dwell-motion filmmakers (the Coen brothers and the Japanese actor-director Takeshi Kitano are acknowledged influences), but his informal facet journeys into the improbable’â€say, an extended daydream sequence that’s half parody of Cultural Revolution propaganda, half karaoke video’â€can solely work in drawing. Illustration, Comics, And Animation Conference From the phrase “cartoon”, the very very first thing that involves your mind is the small humorous characters that you simply see in the cartoon Community channel in your childhood. Then you will love Cover Browser Over 450,000 covers of comics, e-book and extra. Director of this anime movie Hayao Miyazaki is being praised by the movie followers, for providing consideration to the main points of minutes relating crafts and arts within the film. We see a detrimental outline of his physique, adopted by a totally white body, then two slightly completely different photographs of a grotesque mass of mutating and bursting flesh, then a tilted body of a building being hit by flying debris, an image of an electric lighting burst, a picture of the character Akira, for which the film is named, a picture of Tetsuo’s girlfriend trapped in a compartment of fleshy material, and then finally four sequential frames of Tetsuo himself standing up in what’s the mutated kind he will inhabit later in the story. Eyeworks Presents “Double Imaginative and prescient The deliberate Comics and Animation Museum in Hangzhou, China lately introduced the winner of its contest to design the museum, a Netherlands-based structure agency known as MVRDV that envisioned an $one hundred twenty five million interlocking structure of eight buildings shaped like word balloons built that may permit textual content pictures to be projected on to the exterior of the balloons making them “communicate.”The primary building guests enter will feature a show on the history of comics and animation, displayed alongside spiral-formed walkway that rises upward as its chronicle of the 2 media moves from the past to the future. Announced this evening at … Body Jewelry Bodyartforms Plugs, Gauges, Septum Jewelry, Weights, Captives, And More March 11, 2020 Hannah Physique art is the observe of bodily body adornment, alteration or modification by tattooing, piercing, or different means. French artist Michel Journiac’s most famous action was Mass for a Body (1969) where he offered items of blood sausages made together with his personal blood to the audience and invited them to eat – a parody of Catholic liturgy. Some original feminist artists, comparable to Laurie Anderson and Maureen Connor, have developed their artistic practices to use the physique to discover both the feminine condition and the consequences of know-how. The Tattoo and Physique Piercing Institution Registration Act, (410 ILCS fifty four), turned effective July 1, 2007. If life is the best type of artwork, then it seems only natural for artists to make use of the bodily body as a medium. Getting a tattoo from unsterile gear and inexperienced artists can put you, and the artist, at risk for life-threatening infectious illnesses similar to hepatitis or pores and skin infections attributable to sure micro organism. Body artÂ is defined by Part XXVIII of Title fifty one of the Louisiana Administrative Code as “the practice of physical body adornment by registered establishments and operators using, but not restricted to, the following strategies: tattooing, cosmetic tattooing, body piercing, branding, and scarification”. People in ethnic groups additionally used tattooing extensively as a type of ornamentation. Rebecca Horn is a German installation artist most famous for her body modifications resembling Einhorn (Unicorn) – a body-go well with with a very giant horn projecting vertically from the headpiece. Simply as paintings hanging on walls make a room more beautiful, body artwork can enhance a person’s good physical attributes. The Secure Physique Art Act requires, among different issues, physique art practitioners and body art amenities to adjust to the brand new state law, which grew to become efficient July 1, 2012. Favourite locations for physique tattoos are the chest, the higher arms, and the back of the shoulders. Especially in matters of the recent button issues of the time, using the body turned a method for an artist to connect the person with the universal human expertise – one particular person asking others to resonate as an entire. If you’re aware of individuals practising and not using a license or tattooing minors, please full a Minnesota Body Artwork Grievance Kind (PDF) and mail it to us, or contact your local police. Tattoos, in all probability identified by all, are permanent decorations on the body applied through the usage of an electrically ran needle.…	cc/2021-04/en_middle_0086.json.gz/line1797020
__label__wiki	0.603834	0.603834	BEYOND CLIMATE LANDSCAPE LISTENING A CONVERSATION IAN MAURO LEN PETERSON Full Length Feature Film Share the Film BEYOND CLIMATE? A FILM THAT GETS YOU BEYOND THE HEADLINES AND INTO THE HEART OF THE ISSUES. From burning forests and melting glaciers to acidic oceans, people across Canada's Pacific coast are living with the realities of climate change, and this film shows what's at stake if we fail to get BEYOND CLIMATE... Dr. Mauro is the Executive Director of the Prairie Climate Centre and a filmmaker at the University of Winnipeg. He is a former Canada Research Chair, a Fellow of the Royal Society of Canada’s College of New Scholars, Artists and Scientists, and has served on expert panels related to food security, energy issues, and climate change. Dr. Suzuki is a world-renowned scientist, broadcaster, author, activist and co-founder of the David Suzuki Foundation. He is best known as the host of The Nature of Things – a landmark television series with over 50 seasons, the longest running on CBC – and Suzuki has been host since 1979. David has written or co-authored more than 50 books, nearly 20 of which are for children. A CONVERSATION WITH DAVID SUZUKI Drs. Mauro and Suzuki are longtime collaborators. Watch them in conversation about David’s life and perspective regarding the future. 1 hour + An approach to understanding climate change and solutions Beyond Climate represents the most recent segment in Ian Mauro’s trilogy of climate change films across Canada, which also includes Qapirangajuq: Inuit Knowledge and Climate Change (Co-Directed with acclaimed Inuk filmmaker Zacharias Kunuk) and Climate Change in Atlantic Canada. For each of these projects, Mauro and his colleagues listened to the stories, wisdom and observations of people across the landscape. The films show that all Canadians are being impacted by but also finding solutions to climate change. SCREENINGS AND MEDIA Find out more about ticket sales and media coverage Ian Mauro, PhD beyondclimatemovie@gmail.com For theatrical screenings: Wanda Vanderstoop wandav@vtape.org distribution@vtape.org All of Ian Mauro’s climate change films are distributed by: VTAPE 401 Richmond Street West, Suite 452 Toronto, Ontario, M5V 3A8, Canada © 2020 Beyond Climate	cc/2021-04/en_middle_0086.json.gz/line1797022
__label__wiki	0.830956	0.830956	Home Business Gwadar port provides huge trade opportunity to CARs, Afghanistan: Dawood Gwadar port provides huge trade opportunity to CARs, Afghanistan: Dawood Sat, 19 Dec 2020, 12:06 PM ISLAMABAD, Dec 19 (APP):Adviser to Prime Minister on Commerce and Investment Abdul Razak Dawood has said Gwadar port would provide huge opportunities to the energy rich Central Asian Countries and Afghanistan for regional trade connectivity. Talking to APP in an exclusive interview here, adviser Abdul Razak Dawood said that government was prioritizing the economic integration to promote regional trade and connect the regional important trade players with the deep sea port Gwadar. Replying to question, he said that Central Asian Republic (CARs) are demanding to providing them trade facilitation in Gwadar and Bin Qasim sea port for international and regional trade and providing them the facility of the warehouse. Adviser said Deep Sea Port of Gwadar has its own Geo-Strategic and economic importance which was located at the centre of regional connectivity and a possible railway link from Gwadar to Kandhar and other parts of Afghanistan. He said Central Asia via Afghanistan can become a key trade and transportation route for the entire region. Razak Dawood said that Pakistan was actively participating in regional forums of Central Asia Economic Cooperation (CAREC) and Quadrilateral Traffic in Transit Agreement (QTTA) so that maximum benefits could be taken when the Gwadar Port operates at full capacity in near future. Government of Afghanistan has requested Pakistan to provide Cross-Stuffing Facility at Gwadar Port, he said. ALSO READ WHO provides assistance to Pakistan for COVID-19 preparedness He informed that when modalities are finalized by the Federal Board of Revenue (FBR), ample employment opportunities will be generated for the locals. He said development of Gwadar Port under China-Pakistan Economic Corridors (CPEC) would provide more opportunities to establish new industries as huge investment has been pouring in under CPEC and it will also provide the shortest possible route to the goods in transit. He said that with the improvement in Trans-shipment facilities at Gwadar, the whole dynamics of the regional connectivity would be changed. The Adviser said that Gwadar was at strategic location giving China and Central Asia an access to the Gulf Region and the Middle East. He said that in future, it would be a main Sea-gate for the Central Asia. It would also become easy to send products from Xinxiang and Central Asian countries to other regions, he said. Replying to another question, he said that this port was likely to reduce transport time for goods from Gwadar to Western China and the Central Asian Republics by 60% to 70%. Razak Dawood said that all possible steps are being taken by the Ministry of Commerce, in coordination with other stakeholders, to provide modern facilities at Gwadar Port so that goods clearance time may be reduced as per the set international standards. ALSO READ Domestic circulation key to economic recovery in Pakistan: Cheng Xizhong Moreover, in the forthcoming Strategic Trade Policy Framework (STPF 2020-25) special focus has been accorded to Trade facilitation, Economic Infrastructure Development, Transhipment and Development of Economic Corridors (CPEC and CAREC) so that overall policy environment could be improved in general and regional connectivity should be increased in particular, he informed. Responding to a question on Pak- Afghanistan, Preferential Trade Agreement (PTA), he said that in 2015, Pakistan shared a draft Pak-Afghan Preferential Trade Agreement (PTA) with Afghanistan. Subsequently, Afghanistan has shared its comments on draft PTA and its request list and offer lists in November, 2019 and June 2020, he added. Razak Dawood said the work on Afghanistan’s Request List has been undertaken by Ministry of Commerce, in consultation with Government sector stakeholders including Ministry of Industries, Ministry of National Food Security and Research and FBR, as well as private sector. He said that during his recent visit to Kabul in November, the two sides decided to form a Technical Negotiation Committee (TNC) to start negotiations on PTA. The ministry of Commerce has notified its TNC and requested the Afghan side to follow suit, so that first meeting of TNC may be held. Raiq Qureshi WHO provides assistance to Pakistan for COVID-19 preparedness CM GB Muhammad Khalid Khursheed Khan presenting souvenir to Ambassador of Kuwait in Pakistan Nasar Abdul Rehman J Almutairi at GB House CM GB Muhammad Khalid Khursheed Khan meeting with Ambassador of Kuwait in Pakistan Nasar Abdul Rehman J Almutairi at GB House	cc/2021-04/en_middle_0086.json.gz/line1797023
__label__cc	0.623589	0.376411	BlogCustomersTop AppsWebinarsAcademy App Annie News All CategoriesAnalyticsApp Annie ConnectApp Annie NewsApp MonetizationApp Store OptimizationCustomer StoriesEventsMarket DataMobile App StrategyMobile App User AcquisitionMobile GamingMobile MinuteProduct AnnouncementsReportsTop and Trending AppsWebinars Announcing the Top 52 Publishers of 2016 In our annual rankings, we take a look at the publishers leading the app economy. Today, we’re pleased to announce the top publishers of 2016. Earning a spot on the Top 52 is a special honor, reserved for the top-earning publishers on the iOS and Google Play stores. This year saw some major shake-ups as well as a few fresh faces. Check out the full list below. The Analysis Behind the Cards Big Changes in the Top 10 Typically the top 10 undergoes very little change year over year. However, this year proved to be an exception, with three new entrants to the top 10. Additionally, we saw some shifts in the ranks, with Tencent climbing to the top spot (up from #6 in 2015) and NetEase jumping from #9 to #3. Most notably, Niantic made its first-ever appearance on the charts, due to the record-shattering success of Pokémon GO. The United States and Japan Led the Pack Year over year we see that Asian-Pacific publishers dominate the Top 52. This year was no exception, with 30 of the top publishers hailing from that region. But when we look at the country breakdown, it’s clear that the United States and Japan are producing some of the most influential and successful publishers. The Data Behind the Cards The App Annie 52 is comprised of the top 52 earners by combined iOS and Google Play revenue from January 1, 2016 to December 31, 2016 inclusive. Revenue rankings are based on revenue earned from paid downloads and in-app purchases on the iOS App Store and Google Play Store. They do not include revenue earned from in-app advertising or subscriptions outside app store channels. We source our information from App Annie Intelligence, which generates the industry’s most accurate market estimates for the app stores. We then tie everything together with our DNA technology to get a full picture of whole companies — including their subsidiaries. The State of Mobile in 2021: How to Win in a Mobile-Centric New Normal Read the industry’s leading annual report on the State of Mobile in 2021 to take your mobile performance to the next level Introducing Game IQ Level Up with App Annie’s Revolutionary Games Analytics Product App Annie Ascend: Unlock Advertising Analytics Unlock Digital Advertising & Monetization Analytics with App Annie Ascend	cc/2021-04/en_middle_0086.json.gz/line1797024
__label__wiki	0.517868	0.517868	Advancing Your Case Accident & Injury Blog Arizona Accident Statistics Stanley J. Marks Richard P. Traulsen Steven J. German Arizona Motorcycle Helmet Laws Motorcycles are fun vehicles, but they are also inherently dangerous. A motorcyclist has virtually no protection from external crash forces, and motorcycle safety gear is crucial for preventing catastrophic injuries and death from serious accidents. Arizona’s motorcycle helmet laws exist to keep riders safe, and all riders should know these laws and make good decisions about motorcycle safety and appropriate equipment. As of now, Arizona only requires helmets for motorcycle operators and passengers under the age of 18. However, the state does require all riders to wear appropriate eye protection, such as a visor, goggles, protective glasses, or a transparent face shield unless the motorcycle has a protective windshield. The Arizona House of Representatives is currently reviewing House Bill 2246, a revision to the state’s motorcycle helmet law that would require all motorcycle operators and passengers to wear protective helmets regardless of age, but the changed law would allow riders to pay a one-time fee with registration of their motorcycles to nullify the helmet requirement. The new law would not permit police officers from stopping a motorcyclist simply for not wearing a helmet, but if the rider committed a different moving violation or infraction while also not wearing a helmet, the rider could face a $500 fine. Why Wear a Helmet? Many motorcyclists believe that wearing a motorcycle helmet should be a personal choice; the government should not have the right to dictate which risks a private citizen may assume in regard to his or her own safety. Opponents to motorcycle helmet laws often claim that mandated helmet use essentially trades one risk for another; the rider may be safer from head injuries, but a helmet naturally limits visibility and may increase the risk of a crash in some situations. Despite the arguments against motorcycle helmet laws, research shows that motorcycle helmets can and do save lives. According to the Insurance Institute for Highway Safety (IIHS), the fatality rate for motorcycle riders per vehicle miles traveled is 28 times higher than the fatality rate for passenger vehicle drivers. The IIHS also reports several other key statistics in regard to helmets and their effectiveness. Helmet Statistics On average, an appropriately-fitted, Department of Transportation (DoT) approved helmet reduces the risk of fatal head injury in a motorcycle accident by up to 37%. Appropriately-worn helmets also reduce the risk of serious head injuries by up to 67%. More than 5,000 motorcyclists died in 2017 alone. About 38% of these deaths occurred in single-vehicle collisions. About 60% of all motorcyclists killed in 2017 were wearing helmets at the time of impact. For people killed while riding as passengers, helmet use was only at about 40%. About 89% of all motorcyclists killed in 2017 were helmeted in states with universal helmet laws. Only 31% of those killed in states were helmeted with no helmet laws, and about 42% of those killed while helmeted were in states with helmet laws that only apply to some riders and passengers. These sobering statistics should remind all motorcyclists and their passengers that wearing a helmet is generally a wise decision regardless of state laws mandating helmet use. Riders should also remember that choosing not to wear a helmet can complicate recovery after an accident. Not only will a rider without a helmet be more likely to suffer serious injuries, but his or her auto insurance policy may require helmet use for coverage to take effect after an accident. Neglecting to wear a helmet can also lead to a rider absorbing liability for his or her own damages in some cases, further complicating recovery. If you or a loved one recently had a motorcycle accident in Arizona, speaking with a Phoenix motorcycle accident lawyer about your options for recovery is a wise decision. Details of Incident* All Fields Required * December 2020 Product Recalls How to Prove Lost Wages in a Personal Injury Case When to Hire a Truck Accident Attorney in Phoenix What to Do If You Are Injured in a Truck Accident Will a Pre-Existing Condition Affect My Personal Injury Claim? Free Consultation Meet with us, ask questions, get answers and discuss your options completely free of charge. 11201 N. Tatum Blvd. Suite #110 P (602) 254-6071 F (602) 252-0042 Get Directions © 2021 Begam Marks & Traulsen, P.A. All rights reserved. Disclaimer	cc/2021-04/en_middle_0086.json.gz/line1797028
__label__wiki	0.533616	0.533616	Mr Roy William Robert Farrell Consultant ENT Surgeon MB, MA, BCL, BAO, FRCSI, FRCS Middlesex, BMI Bishops Wood Hospital Middlesex, BMI The Clementine Churchill Hospital Thyroid & other neck lumps + Cosmetic surgery + ENT surgery Cholesteatoma surgery Grommet insertion Septoplasty and submucous resection Septorhinoplasty with graft or implant Sleep studies snoring clinic Thyroidectomy for Goitre Thyroidectomy for Nodule Tonsillectomy adult Total thyroidectomy + Paediatrics Adenoidectomy for children Tonsillectomy child Roy Farrell was born in Dublin. He qualified in 1983 from Trinity College Dublin in Medicine. For the next five years he pursued a career in General Surgery with a special interest in Endocrine and Thyroid Surgery. Having completed that part of his training he moved to Sheffield to commence training in Otolaryngology with a special interest in Head and Neck cancer. During his time there he completed an active research programme in the role of viral infections and their role in the aetiology of Head and Neck cancer. In 1996 Mr Farrell moved to London to complete his training at the Royal Free Hospital, Great Ormond Street Hospital and Royal National Throat, Nose and Ear Hospital. In 1998 he commenced his Consultant post at London North West University Healthcare NHS Trust and quickly became a Clinical Director firmly establishing a Head and Neck unit within this Trust which is thriving today. Special interests are through the wide range found in Otolaryngology with special interest in Head and Neck and Thyroid disease, Paediatric, nasal problems and cosmetic reconstruction of the nose and face.	cc/2021-04/en_middle_0086.json.gz/line1797030
__label__cc	0.680232	0.319768	The Reimagined Party Democracy, Change and the Public Katharine Dommett Political parties are an established feature of contemporary democratic politics. For decades, parties have organised government, competed in elections and influenced the way society is run. Yet despite their importance, the status of political parties in society is presently unclear. Les mer Leveringstid: Sendes innen 21 dager Vår pris: 1350,- Political parties are an established feature of contemporary democratic politics. For decades, parties have organised government, competed in elections and influenced the way society is run. Yet despite their importance, the status of political parties in society is presently unclear. On the one hand lambasted as duplicitous, self-interested, dogmatic organisations that are in decline, on the other they have been proclaimed as resurgent bodies that are attracting new levels of membership and support. The reimagined party offers unprecedented insight into public views of parties in Britain. Exploring public perceptions and desires, Katharine Dommett finds that far from rejecting parties, there is ongoing support for party democracy. The book presents evidence of a desire for change in party ethos, introducing the idea of the re-imagined party to explore perceptions of party representation, participation, governance and conduct. Using a mixed-method approach, and presenting hitherto unseen data, the book casts new light on citizen's desires for parties today. -- . Forlag: Manchester University Press Politisk kampanje og reklame Politiske strukturer og prosesser	cc/2021-04/en_middle_0086.json.gz/line1797032
__label__cc	0.712624	0.287376	Nancy H. Boler Dedicated to offering professional and personalized support in the area of divorce and family law. Family law questions? I can help. Call today. Serving The Houston Metro \| Free Initial Consultation Lawyer Profile Post Divorce Issues How is paternity determined in Texas? Since the advent of DNA testing, determining paternity has never been easier. Indeed, some companies even provide take-home paternity tests. But, despite the ease of such testing in today’s world, paternity is nevertheless something that must be taken seriously. After all, establishing paternity through genetic testing is often the only way to conclusively resolve disputes related to child support and/or parental rights. However, it is important to note that genetic testing is only one of several ways in which to establish paternity in Texas. Paternity by presumption The first way to establish paternity in Texas is by presumption. In fact, Texas law delineates certain situations in which a man will be presumed to be a child’s father. For example, if a child is born while the alleged father and the mother are married, or born within 300 days of their divorce, the man will be presumed under the law as the child’s father. Normally, once paternity is ascertained by presumption, it can only be refuted by adjudication or by the filing of a denial of paternity by the presumed father in combination with the filing of an acknowledgment of paternity by another person. Moreover, if a presumed father wishes to challenge paternity through adjudication and court order, he must do so before the child reaches the ages of four. After that time, he can only dispute paternity under certain circumstances, including situations in which: The presumed father and the child’s mother did not live together or engage in sexual relations at the time of conception The presumed father was prevented from adjudicating paternity because misrepresentations led him to mistakenly believe he was the child’s biological father Acknowledging paternity in Texas Secondly, paternity can be established by acknowledgment in Texas, which typically requires both the father and the mother to sign a document recognizing paternity. However, this acknowledgment may be considered invalid if it does not meet the strict guidelines laid out under Texas law. After signing a valid acknowledgment of paternity, the father does have a 60-day window in which he can attempt to rescind the document. However, after that time, Texas law states he can only challenge the acknowledgment on the grounds of duress, fraud or material mistake of fact. Paternity by adjudication and court order The final way in which paternity can be established in Texas is by using adjudication to obtain a court order. Often times, it is during this legal proceeding that genetic testing comes into play. Importantly, adjudication of paternity can be commenced at any time so long as no one has already been named as a child’s father through presumption, acknowledgment or previous adjudication. However, time limitations may exist if a man has already been identified as the father of the child. Paternity disputes in Texas can often become quite complex. However, given the serious consequences associated with a paternity determination, it is important to seek the counsel of an experienced attorney to ensure you are aware of all relevant laws and procedures. A skilled paternity attorney can help explain your rights and assist you with filing any claims. Schedule a Confidential Evaluation What is ‘Malicious Parent Syndrome’? Some divorces go very smoothly and almost write themselves, but others can become extremely contentious and very messy. Particularly if children are in your divorce, it has the potential to become extremely stressful if you are on acrimonious terms with your... How children’s custody preferences affect a custody hearing During a divorce, the spouses and the courts make most of the important decisions, including who the children live with primarily. According to the Family Code statute, when deciding who has primary custody or conservatorship, the courts consider the best interests of... What will become of your business now that you face divorce? If divorce is in your future, your business will likely be the main focus in the property division phase of the proceedings. You may have many questions about the fate of your business but there are three basic options to consider. The buyout The option many divorcing... Law Office of Nancy H. Boler 6575 West Loop S Bellaire Law Office Map © 2021 Law Office of Nancy H. Boler. All Rights Reserved.	cc/2021-04/en_middle_0086.json.gz/line1797033
__label__wiki	0.608963	0.608963	Belly Wine Bar Now Has a Queen-Inspired Wine List By Christopher Hughes· “Freddie Mercury performing in New Haven, CT, November 1978” by FreddieMercurySinging (Creative Commons) You could never accuse Belly Wine Bar owner Liz Vilardi of adhering to stuffy wine traditions with a beverage program organized into categories like “South Central,” “We Dare You,” and “Short Skirt, Long Jacket” (yes, like the Cake song). Her new fall wine list, of course, is no different. We’re fast approaching harvest time in the world’s wine growing regions, and for Vilardi that means celebrating fresh “natural wines” and the music of Queen—specifically an a-cappella version of “We Will Rock You.” “In 2004 I was driving by myself in the Piedmont [Italy] and hardcore listening to some Queen,” Vilardi says. “There was this a-cappella version of “We Will Rock You” without the cliche ‘stomp, stomp, clap’ you associate with basketball games and things like that. I had the windows down and it was cool, and it reminded me of September, which is my favorite month of the year. I was there during harvest time and I started thinking about people actually digging in the dirt with mud on their face, particularly natural winemakers who some consider controversial. It was this formative experience for me and I’ve always wanted to share that memory.” Vilardi’s “Mud on Your Face” menu—with Queen lyrics running down the center of the page—features the work of winemakers such as Jean-Marc Burgaud, Erich Weber, and Hank Beckmeyer, all advocates of the growing natural wine movement. The somewhat ambiguous, highly contentious practice involves organic and biodynamic cultivation, a rejection of commercial yeast strains, and a minimum use of additives and technological manipulations. The new list, introduced earlier this week, will run until harvest season ends in mid-October. With over 20 natural wines, it’s easily the highest concentration of these unique, cultish wines featured anywhere in the city. “I want people to know that these small-production wines didn’t just appear, they were made by these bold winemakers,” Vilardi says. Belly Wine Bar Wine List 1 Kendall Square B4201, Cambridge; 617-494-0968 or bellywinebar.com. Source URL: https://www.bostonmagazine.com/restaurants/2014/09/11/belly-wine-bar-queen-inspired-wine-list/	cc/2021-04/en_middle_0086.json.gz/line1797039
__label__wiki	0.99711	0.99711	Minnesota bowler wows crowd with 300 game at USBC Open @USBC ITRC Womens Championships By Jessica Gilgor USBC Communications RENO, Nev. - Kevin VonderHaar of Hibbing, Minn., left his teammates jumping for joy when he became the 15th bowler to roll a perfect game at the 2014 United States Bowling Congress Open Championships. The 55-year-old right-hander sandwiched the 300 between games of 188 and 180 Wednesday for a 668 series. His efforts helped his team, Hibbing Bowling Center 1, to a 2,696 total. Motion Plus Lanes of Cudahy, Wis., leads Regular Team with a record score of 3,561. "I was shaking," said VonderHaar, who made his 17th USBC Open Championships appearance. "I've bowled a few other 300s this year and had no problem. But being here at the Open Championships is different." VonderHaar struggled to find a line early in the day, but he made the necessary adjustments on his way to 12 consecutive strikes. "The second half of the first game, I started getting lined up and then left a 10 pin," said VonderHaar, who manages Hibbing Bowling Center. "I said 'OK, I'll line it up here,' and that was it. I threw 11 good ones and one Brooklyn." During his run at perfection, VonderHaar was able to keep his composure despite the pressure, even with the vocal support of his teammates, which increased with every strike. "I didn't really pay attention," VonderHaar said. "I could hear them, but I was just taking deep breaths, trying to stay focused." Before making his appearance at this year's Open Championships, VonderHaar practiced on the 43-foot Sport Bowling-certified team lane condition at his own center and then took advantage of practice sessions available at the Track Showcase Lanes on the ground floor of the National Bowling Stadium. VonderHaar added a 650 series in singles and 554 in doubles for a 1,872 all-events total. Visit us on Facebook at the official USBC Open/Women's Championships page. Presenting sponsors for the 2014 USBC Open Championships include Circus Circus Reno, Eldorado Hotel Casino Reno and Silver Legacy Resort Casino Reno.	cc/2021-04/en_middle_0086.json.gz/line1797040
__label__wiki	0.816705	0.816705	About the Bridgend Male Choir The Bridgend Male Choir (Cor Meibion Pen-Y-Bont) was established in August 1960 as the Bridgend & District Police Choir, when membership was mainly police officers. The name then changed in 1987 to the Bridgend and District Male Choir with the name simplified in 2006 to Bridgend Male Choir. Ffurfiwyd Côr Meibion Pen-y-bont yn Awst 1960 fel Côr Heddlu Pen-y-bont a’r Cylch, ac ar y pryd yr oedd y mwyafrif o’r aelodau yn heddlu. Newidwyd yr enw yn 1987 i Côr Meibion Pen-y-bont a’r Cylch, cyn ei symleiddio yn 2006, fel Côr Meibion Pen-y-bont. Choir Present Bridgend Male Choir, whose motto is 'Friendship Through Music', is a member of the Welsh Association of Male Voice Choirs and is now composed of some 90 members led by a professionally qualified music team. The choir is made up of men from all walks of life who have a passion for music and a desire to share their music with others. Concerts and functions are regularly staged with approximately 60 choristers. They have a large repertoire, which encompasses all aspects of Welsh male choral music, including contemporary compositions, traditional music, hymns and folk songs as well as many musical arrangements from other countries and cultures. The majority of the concerts the choir perform are in aid of deserving charities and good causes throughout the UK and abroad. Rehearsals take place at Oldcastle School, Bridgend, CF31 3ED, South Wales, on Thursday evenings from 7.30pm – 9.30pm and visitors are most welcome to come along and enjoy the rehearsal. The choir is an equal opportunities organisation. Y Côr Presennol Mae Côr Meibion Pen-y--bont yn aelod o Undeb Corau Meibion Cymru. Arwyddair y côr yw “Cyfeillgarwch drwyr miwsig ”, ac mae tua 90 o aelodau, gydag oddeutu 60 o gantorion yn llwyfannu yn rheolaidd mewn cyngherddau a digwyddiadau tebyg, dan arweiniad tîm o gerddorion proffesiynol. Daw’r aelodau o bob math o alwedigaethau, ac maent wedi eu uno trwy eu diddordeb mewn canu a’r awydd i rannu eu cerddoriaeth gydag eraill. Mae gan y côr rhestr eang o ganeuon, gan gynnwys caneuon cyfoes a thraddodiadol, emynau, caneuon gwerin a threfniadau o ganeuon o wahanol wledydd a diwylliant. Mae Côr Meibion Pen-y-bont, drwy eu perfformiadau, yn cefnogi, ac yn helpu codi arian, er lles elusennau haeddiannol drwy’r D.U. a gwledydd tramor. Cynhelir yr ymarferion yn Ysgol Gynradd Hengastell, Pen-y-bont ar Ogwr, CF31 3ED, De Cymru, ar Nos Iau 7.30 – 9.30 yh. Mae croeso i ymwelwyr ddod i’r ymarferion. Mae Côr Meibion Pen-y-bont yn hybu cyfleoedd cyfartal. Bridgend Male Choir - Historical Past In 2010, the Choir celebrated its 50th Birthday and was awarded a Citizenship Award from the Mayor of Bridgend County Borough Council for 50 years of fundraising, having generated in excess of £1Million for charity and for being ambassadors for Bridgend. Over past decades the choir has won a number of musical competitions and Eisteddfodau. A remarkable double victory was scored at the 1991 Concorso Internazionale Di Canto Corale, a prestigious festival held in Verona taking in 20 top choirs from 6 countries, resulting in an award of another silver cup in April 2003. This was followed by: ▫ 1st prize, winning the Welsh Fusilier’s Cup, at the 2004 Welsh National Eisteddfod in Newport and again at Swansea in 2006; ▫ “Best Male Choir” in S4C’s Cor Cymru (Choir of Wales) competition in 2005; ▫ Winning both the Folk Song and Male Voice sections at Cheltenham Music Festival in 2006, and awarded "the best choir from all competitions. ▫ Joint Runner Up at the Isle of Man Festival of Choirs Competition in 2013. ▫ Winning the Male Choir section at Llangollen International Music Eisteddfod in July 2014. Visits abroad have included three visits to Bridgend's German twin town of Langenau (1979), two to Berlin, one to Canada, one to France, two to Jersey and two to Italy. Others include the Republic of Ireland (2004), then known as 'Eire', and Spain (2005). 2006 saw the Choir in the German cities of Stuttgart and Ludwigsburg and the towns of Shwieberdingen and Weissacht-Flacht; 2007 brought a tour to Northern Ireland, including Belfast, Craigavon and Dunmurry and in 2008 to the city of 's-Hertogenbosch, Netherlands, to participate in its Liberation celebrations. The 50th Anniversary Tour in 2010 was to the north west of England, with concerts on the Wirral and at Burnley; this was followed in July 2011 with the Choir touring in the Scottish Highlands. In 2012, the Choir travelled to North Wales giving concerts at Llandudno's St John's Methodist Church and at St Asaph Cathedral. October 2013 witnessed the Choir's first ever visit to the Isle of Man where it performed at the Villa Marina in the IOM Music Festival. The Choir was extremely proud in 2014 to have been invited to return to the Netherlands to participate in the 70th WW2 Liberation Concert at 's-Hertogenbosch, coincidentally also the 100th Anniversary of the start of World War 1. Choristers sang and laid a wreath at the Menin Gate, Ypres, Belgium, an equally moving occasion. October 2016 saw the choir successfully visit Dublin and Drogheda where three concerts were staged and substantial funds raised for the Dublin Lions and Malta Services respectively. Choristers visited Majorca in October 2017 where amongst other venues they performed in front of over 1000 at the magnificent Gothic Cathedral in Palma. The Choir has shared the professional stage with such as Wales' national treasure Katherine Jenkins and Max Boyce, soprano Shan Cothi and tenor Dennis O'Neill, and operatic bass/ baritone, Sir Willard White. In November 2007, the choir sang the Welsh National Anthem prior to Joe Calzaghe World Title fight against Mikkel Kessler which was screened live to a world wide audience on Sky Sports. A list of singers and celebrities the Choir has sung with can be found under concert reviews. Bridgend Male Choir is proud that the original website was registered with the National Library for Wales having been included in the UK Web Archiving Consortium as "an important part of Wales' documentary heritage". CONCERTS / NEWS / JOIN / SHOP / CONTACT / PRIVACY	cc/2021-04/en_middle_0086.json.gz/line1797041
__label__wiki	0.888026	0.888026	Pep Guardiola was puzzled by Ashton Gate pitch ahead of Man City's Carabao Cup second leg against Bristol City The Spaniard was confused over the markings on the Ashton Gate pitch Pep Guardiola was very complimentary about Bristol City after the first leg of their Carabao Cup semi-final first leg - but appears to have misunderstood one thing. Bristol City’s attentions are turning towards the visit of Norwich City following that epic encounter up at the Etihad Stadium. The Robins have been holding their pre-match press conference on Thursday and the Bristol Post asked assistant Dean Holden if he had had a chance to speak with Pep Guardiola after Tuesday night’s great battle. The former Bolton Wanderers defender revealed that Guardiola had been very complimentary. “Yeah, we got invited in with Pep after the game. All the coaching staff went in there with Pep and his sporting director Txiki Begiristain was there,” explained Dean Holden. Pep Guardiola and Lee Johnson Man City star incredibly blames Carabao Cup ball for lacklustre Bristol City display “It was a great 15-20 minutes that we had with him. “Pep was very, very complimentary, as was Mr Begiristain, about the way that we played – he was asking us little questions. Like the lines that we had on our pitch here at Ashton Gate. “He asked us if it was a tactical thing that we use, and we said ‘no it’s plainly for the rugby markings’. He obviously knew a lot. “He mentioned that he’d spoken to his players about what a good team we are. The way we’d gone up against previous Premier League teams, Manchester United included, and done very well. “He was under no illusions that we’re a good team. For someone of his calibre to be speaking about Bristol City like that shows what a good season we’re having.” Joe Bryan of Bristol City is challenged by Danilo of Manchester City 'We can't treat Manchester City like superstars' says ambitious Bristol City forward Bobby Reid Meanwhile, Holden also revealed that the Robins are champing at the bit to get back out on the pitch. The Post asked about lifting the City players following four defeats in a row and the intense game against the Citizens. “Well I’ve just come straight from the training ground. I’ve been sat among a couple of players having lunch to gauge where they’re at. “I won’t name them but there are two of them who are literally saying they can’t wait to get back on the pitch. Man City 2-1 Bristol City - reaction Pep salutes Robins Johnson proud “They don’t normally say things as clear as that. The training ground has been really bubbly this morning. There’s a lot of optimism around and the lads will be really flying, I’m sure. “It’s not just hearsay. They’ve proved time and again this year that they can focus on the next challenge and that’s the name of the game in the Championship: the amount of games you play,” he said. There are no new injuries to report while Famara Diedhiou is getting closer to being able to be involved. Bristol City play Norwich City on Saturday at 3pm.	cc/2021-04/en_middle_0086.json.gz/line1797047
__label__wiki	0.705216	0.705216	Subscribe to The Brown Daily Herald Newsletter Sign up for The Brown Daily Herald’s daily newsletter to stay up to date with what is happening at Brown and on College Hill no matter where you are right now! Read the Print Edition Reprint and Permissions Requests Men’s Water Polo Men’s Ice Hockey Women’s Ice Hockey Post- Magazine Paxson addresses vaccines, political polarization, sustainability in President’s Welcome 2021 Guide To Brown RISD President Rosanne Somerson to retire ‘A historic moment in time for this democracy’: Watson inauguration talk shifts focus to Capitol riots News, University News Some remote students receive emails from Brown accusing them of violating code of student conduct Emails alleged students were in Providence area, violating remote status, some students’ charges have been withdrawn By Katie Chen Elise Ryan / Herald Several students erroneously received emails alleging they had been in the Providence area between Sept. 14 and 21 and therefore had violated the Code of Student Conduct. As the University pushed for students who have opted for remote status but are living in Providence to enroll in its testing program last week, some students erroneously received emails alleging that they had been in the Providence area and had violated the Code of Student Conduct. Emails have since been sent to students to rectify the allegations and withdraw the conduct charges, according to University Spokesperson Brian Clark. Some students were left feeling frustrated by the error. “I knew I was not going to be suspended because I know that I was not in Providence then, but I’m still very shaken that Brown would accidentally threaten to suspend students so haphazardly,” Nathaniel Ostrer ’21, who has been taking class from New York, wrote in a message to The Herald. Ostrer received both a Thursday email claiming he’d been in Providence and a more recent follow-up email, withdrawing his charges. The emails, reviewed by The Herald, alleged that recipients had been in the Providence area between Sept. 14 and 21, and therefore had violated the Code of Student Conduct. Students were told that they could either accept responsibility for their violation or have a COVID-19 Dean’s Review Meeting. If students accepted responsibility without a review meeting, they would have been placed on probation until Jan. 19, 2021, as well as be required to change their location of study, submit their Student Commitment to COVID-19 Community Health and Safety Requirements within 24 hours, provide their off-campus address and enroll in the University’s COVID-19 testing program. The fact that a mistake like this could occur “doesn’t give me a lot of faith in the systems Brown has set up to fight COVID-19” Ostrer wrote. Lev Simon ’22, who said he is currently living with some other Brown students in another state, thought he might have received the initial email because he changed his status to remote later than most students, or that it had something to do with an order he placed at the Brown Bookstore. Simon said his housemates did not receive this email. When he received the initial letter he wasn’t afraid of probation; instead, Simon said, “I just wish this kind of hadn’t ruined my day and distracted me from my classes.” In a follow-up email sent to Simon from Associate Dean Kristen Wolfe and reviewed by The Herald, Wolfe wrote that the charges against Simon had been withdrawn, his case had been deleted from their database and he was not expected to take any further in response to their Thursday letter. “We understand that the letter you received likely caused confusion and anxiety,” she wrote. “We apologize sincerely for this error and its impact on you.” According to Clark, students “were identified based on a range of factors, including, for example, indications of having accessed buildings or facilities on our campus directly, having accessed private university electronic services or secure networks from the Providence area, and/or reports from other community members.” Over the summer, students were asked to fill out a Fall 2020 Location of Study form indicating whether they planned to study on campus, off campus in the Providence area, remotely, as a commuter or in housing at the Rhode Island School of Design. “If you chose ‘remote’ as your location of study, you are affirming that you have no intention to visit the campus or reside in the Providence area,” according to an FAQ from the Office of Residential Life. Visiting campus “is a violation of the Code of Student Conduct.” On Thursday, President Christina Paxson P’19 also sent a community-wide email, asking students living in Providence but registered under a remote status to come forward and enroll in the University’s testing program, The Herald previously reported. “I am very concerned about reports that a number of students who have signed up for ‘remote status’ … have actually returned to the area and are living in apartments around campus,” Paxson wrote. These students “pose a danger to the entire community and could undermine everyone’s efforts to have a healthy and successful semester,” she added. “If you are one of these students, please let us know you are here,” Paxson wrote. She also urged other students who may know of peers violating the conditions of their remote status to encourage those classmates to come forward. Topics: COVID-19, Student Conduct To stay up-to-date, subscribe to our daily newsletter. The Party says: This is what happens when you give up your rights to tyrants who have no intention of giving them back. All in the name of “safety” for a disease with a 99.99% survival rate among college age students (CDC data). And now, back to your regularly scheduled fear porn. Reynolds Woodcock '13 says: what’s the survival rate of older people who get infected by those college students? Get a clue. Marc McReynolds says: Providence College went with an approach closer to your hands-off admonition, and now a few weeks into the school year they are already screwed… unless someone figures out how to run the place solely with 18-25 year-olds… who are themselves ok with various organ-damage risks (CDC data). I’m guessing the Brown admin tyrants are in reality quite anxious to hand back the students’ “rights” as soon as they reasonably can, allowing a return to whatever things they used to do for a living before they got stuck with herding cats. GWS (parent of a truly remote student '21 and relative of employees and Providence residents) says: It’s not just the young college students that are affected – it’s the entire community – employees, local residents and businessowners, etc. For the sake of the broader community’s health, I would rather have Brown over-identify than under-identify any potential remote/off-campus “scofflaws”. But yes, Brown must research and rectifiy errors when accusing students. It’s not just the young college students that are affected!! The entire community is affected – employees, local residents and businessowners, etc. For the sake of the broader community’s health, I would rather have Brown over-identify than under-identify any potential remote/off-campus “scofflaws”. But yes, Brown must research and rectifiy errors when accusing students. Brown leases rooms in Omni Providence Hotel to house students for spring semester Brown students, alumni in D.C. reflect on attack on the Capitol RISD cancels in-person commencement Brown’s fall semester comes to gradual close As classes wrap up before Thanksgiving break, many students are packing their bags... The COVID Pod with Dr. Ashish Jha: Thanksgiving, Travel and Testimony On this bonus episode of The COVID Pod with Dr. Ashish Jha, Dean of the School of... Brown classes shift back to online due to rising COVID-19 cases All undergraduate and graduate classes, with the exception of Warren Alpert Medical... THE COVID Pod with Dr. Ashish Jha: The Future of Pfizer’s Vaccine and President-Elect Biden’s Transition Team On Friday, Nov. 13, Dr. Ashish Jha joins The Herald’s COVID Pod team to discuss... Daily Newsletter (Headlines) a full family affair things we’re thankful for this holiday season polishing off the thanksgiving plate Copyright © 2021 Brown Daily Herald. 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__label__cc	0.628637	0.371363	Rolex at Bucherer 279384RBR Model case Oyster, 28 mm, Oystersteel, white gold and diamonds All prices are Rolex’s suggested retail price inclusive of V.A.T. The prices of gem-set models are dependent on market fluctuations and therefore subject to variations. Rolex reserves the right to modify the prices and models on this website at any time. Call us on +44 207 292 0345 Contact us Find a store Set with diamonds Waterproof to 100 metres / 330 feet Perpetual, mechanical, self-winding Oyster, flat three-piece links Dark grey set with diamonds Dark Grey Dial The sunray finish on Rolex dials is a predominant method in watchmaking of achieving pure metallic colour dials such as shades of silver grey, rhodium or ruthenium. The Fluted Bezel The Rolex fluted bezel is a mark of distinction. Originally, the fluting of the Oyster bezel had a functional purpose: it served to screw the bezel onto the case helping to ensure the waterproofness of the watch. It was therefore identical to the fluting on the case back, which was also screwed onto the case for waterproofness, using specific Rolex tools. Over time, the fluting became an aesthetic element, a genuine Rolex signature feature. Today the fluted bezel is a mark of distinction, always in gold. White Rolesor Therefore, the availability of certain models may be limited. New Rolex watches are exclusively sold by Official Rolex Retailers, who receive regular deliveries and independently manage the allocation and sales of watches to customers. Bucherer is proud to be part of the worldwide network of Official Rolex Retailers and can provide information on the availability of Rolex watches. Rolex’s classic feminine watch, the Lady-Datejust is in the lineage of the Datejust, the emblematic model that has been a byword for style and accurate timekeeping since its launch in 1945. The first women’s version of this date chronometer, the Lady-Datejust, appeared in the late 1950s, bringing the heritage of timeless elegance and functionality to a smaller size perfectly suited to a lady’s wrist. Select One OptionMr.Ms.Mx. 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I would like to subscribe to the Bucherer newsletter Oyster, 31 mm, Oystersteel, Everose gold and diamonds Oyster, 31 mm, Oystersteel, yellow gold and diamonds	cc/2021-04/en_middle_0086.json.gz/line1797052
__label__cc	0.591485	0.408515	> Technology > Technology Solutions Ooma Review Chad Brooks Thanks to its simplicity, flexibility and affordability, Ooma Office is our choice as the best phone system for very small businesses. The system is built with small businesses specifically in mind. Unlike many of today's business phone systems, Ooma provides flexibility in how the system is run and the types of phones it can work with. You have the choice of installing some equipment – which you can do on your own, without IT experience, and using analog phone you may already own – or you can use IP phones with a traditional cloud-hosted setup. These aren't options most business phone system providers offer. Ooma The Best Business Phone Systems of 2021 Ooma Office is our choice as the best business phone system for very small businesses. This affordable VoIP system is easy to move to new offices; works with IP, analog and mobile phones; and offers the features very small businesses need. While the system doesn't have all the features some of its larger competitors do, it offers some of the most valuable ones, like auto-attendants, voicemail and call forwarding. The system is extremely affordable and offers round-the-clock support. View all our recommendations for business phone systems on our best picks page. Ooma Office Pricing The pricing structure for Ooma Office depends on what type of phones your business uses. If you use IP phones, all you have to pay are per-user monthly fees. If you want to use analog phones with the system, there are also some one-time equipment fees to consider. Whether you use IP or analog phones, you have a choice of two service plans: Ooma Office or Ooma Office Pro. Ooma Office is $19.95 per user per month, while Ooma Office Pro is $24.95 per user per month. Ooma Office Pro is a relatively new offering. We like that it increases the number of features and tools and the likelihood of businesses sticking with the solution as their needs grow. Instead of having to switch providers altogether, you can pay an additional $5 a month per user for that increased functionality. Ooma Office offers more than 35 features, including a virtual receptionist, music on hold, extension dialing, voicemail and call blocking. Ooma Office Pro adds features like call recording, a desktop app and voicemail transcription. If you have analog phones you want to continue using, you will need a few pieces of equipment. The basic equipment package starts at $129.97. It includes the base station, which is the system's main component, and two Linx devices, which are used to connect analog phones to the system. IP phones can be plugged directly into an Ethernet port and don't need any special connection. Since each base station supports five analog phones, you may need additional base stations, which are $100 each. If you don't have analog phones you need to use, none of this equipment is necessary. Another cost to consider is desk phones. Unlike with other business phone solutions that require IP phones, you can use analog phones with Ooma Office. However, you can add more users to the system if you use IP phones. Ooma offers several different Yealink and Cisco phones, ranging from $70 to $400. There are no contracts with Ooma Office. You make all payments on a month-to-month basis. The company offers a 30-day, risk-free trial. While it doesn't have the wide selection of features that some other phone systems offer, Ooma Office does have the calling and mobile tools very small businesses need most. Although it sounds nice to have all the accessories today's phone systems offer, most would go unused by very small businesses. Ooma keeps its prices down by only providing the features very small businesses need most. Ooma Office's features include unlimited local and long-distance calling, a virtual receptionist, voicemail, call transfers, call logs, daytime and after-hours modes, ring groups, music on hold, call forwarding, and online faxing. Ooma Office Pro offers even more features and tools. For the extra $5 a month per user, you have access to a desktop app, which lets each user check out the company directory, manage calls and set up ring groups. Other features in the upgraded plan include call recording, enhanced call blocking, voicemail transcription and overhead paging. Ooma Office Pro also includes video conferencing services for up to 25 participants at one time. Ooma has a mobile app for both iOS and Android devices that lets employees make and receive calls using their business lines. When you make an outgoing call from the app, the person you call will see your business phone number on their caller ID, not your personal mobile number. With the mobile app, you can also transfer calls to other employees, listen to and manage your voicemails, and easily access co-workers' extensions. Ooma Office Pros Even someone without any phone system expertise can install the Ooma Office on-premises VoIP system in less than 20 minutes. While the system only supports up to 20 analog phones, it can support up to 200 IP phones. If you use IP phones, you can set up the system quickly. All you need to do is plug the phones into your LAN. Once plugged in and powered up, they are ready to make and receive calls. If you use analog phones, you need to set up your base station and Linx devices to get the system working. The base station serves as a full router, prioritizing voice data on your internet connection. This helps ensure solid reception on each call. The other main component is the Linx device. The option to use analog phones you already have, without having to purchase new IP phones, can be a big cost-saver for very small businesses and a nice benefit of this service. You first connect the base station to your high-speed internet connection. You then plug the base station's AC adapter into an electrical outlet. For the best service, Ooma recommends that you have at least 256Kbps upstream and downstream for each simultaneous call during peak usage times. Once the base station is connected, you then plug an analog phone into the unit. Once everything is up and running, you control the system via Ooma's online portal. The portal, which is easy to use and navigate, is where system administrators assign employees extensions and phone numbers, set up the automated attendant, and create ring groups. Ooma Office Cons Ooma doesn't offer all of the features that some of its competitors do. So, if you are looking for a solution that offers every possible feature and tool, this system might not be a perfect fit. Another potential downside is the conference calling participant restrictions. If you only get the Ooma Office plan, you are limited to 10 callers at a time. The good news is that Ooma has upped those limits with the recent introduction of the Office Pro plan. We were pleased with the customer support we received from Ooma. To test the level of service, we contacted the company numerous times by phone, email and live chat, posing as a microbusiness owner interested in its phone system. Most of our interactions with the company were positive. Representatives immediately answered most of our calls. There were a couple of times, however, when our calls weren't immediately answered – or were picked up, but no one was on the other end of the line. Overall, the representatives we spoke to gave detailed answers to our questions about how the system works, the available features, the mobile app and pricing. There were a few times the responses didn't provide as much detail as we wanted, though, and we then had to contact Ooma again for further information. Each time we followed up with a representative over email, they immediately responded. We also found the live chat service helpful. With some providers' live chat services, it took a long time for a customer service representative to answer our questions, but we got prompt responses from the Ooma team. Ooma provides 24/7 phone, email and live chat support. Image Credit: scyther5 / Getty Images See Chad Brooks's Profile Chad Brooks is a Chicago-based writer and editor who has spent more than 20 years in media. A 1998 journalism graduate of Indiana University, Chad began his career with Business News Daily in 2011 as a freelance writer. In 2014, he joined the staff full time as a senior writer. Before Business News Daily, Chad spent nearly a decade as a staff reporter for the Daily Herald in suburban Chicago, covering a wide array of topics including local and state government, crime, the legal system and education. Chad has also worked on the other side of the media industry, promoting small businesses throughout the United States for two years in a public relations role. His first book, How to Start a Home-Based App Development Business, was published in 2014. Related Best Picks See More Related Best Picks RingCentral Review Grasshopper Review Nextiva Review More Related Best Picks Which is better: chatbot or live chat? Milita Khokhlova What employee monitoring software do you use? Lori Fairbanks Domain Editor Which software do you recommend using to manage your team remotely? Daniel Elton Business Development Strategist	cc/2021-04/en_middle_0086.json.gz/line1797054
__label__cc	0.73428	0.26572	Download Forms »Schedule an Appointment » Covid-19 Info » Triad Phone: 336-448-9100 Charlotte Phone: 844-686-2233 Asheville Phone: 828-767-1643 Questions? Ask the doctor Age and Fertility Fertility Testing About Ovest Follow Sydney’s Journey Our Counseling Services Promise Program CFI Baby Photos Genetics and Fertility Videos CFI Injection Videos CFI Educational Presentations Therapeutic Activity for Patients CFI Moms and Supporters CFI Baby Reunion Photos 2016 EmbryoScopeⓇ Egg Recipient CFI Affiliate Locations Charlotte Location In order to conceive, a man’s sperm must travel up to the vagina, through the cervix, into the uterus and into a fallopian tube where an egg is fertilized. Unfortunately, a man’s sperm is not always able to make this trip or a woman’s cervix may not allow the sperm to travel. When any of these issues arise, artificial insemination, a popular fertility treatment, may be recommended to assist a woman in conceiving. Here at Carolinas Fertility Institute, we may recommend artificial insemination if: A woman is under 35, has had six months of unprotected sex, and was not able to get pregnant. A woman is over 35 and has not been able to get pregnant after a year of unprotected sex. Types of Artificial Insemination The two types of artificial insemination include ICI and IUI. Let’s dive deeper into each one. ICI involves inserting the sperm into the cervix, which is the passageway outside the uterus. A woman undergoing this treatment will monitor her ovulation cycle and/or take medications to induce ovulation. Their partner will then donate sperm so that a doctor can use a syringe to insert it into the woman’s vagina. A woman will lie down for 15 minutes to a half hour so that the sperm can travel into the uterus. Once the treatment is complete, a woman will take a pregnancy test in a few weeks to determine whether ICI was successful. In an IUI, the sperm is inserted past the cervix and directly into the uterus. The process for this procedure is similar to that of ICI. However, it includes additional steps. The semen will be prepared or washed to remove any proteins that may impair fertilization. This will allow the sperm to become more concentrated and increase a woman’s chances of getting pregnant. Additionally, a doctor will use a speculum to make the uterus easier to access. It is thin tool and will be inserted through the vagina so the sperm can be placed into the uterus. A woman’s age, the use of fertility medications, and underlying fertility concerns all play a role in the success of ICI or IUI. After six treatment cycles, the pregnancy success rate for ICI is 37.9 percent. For IUI, the success rate is 40.5 after six treatments. Contact Carolinas Fertility Institute If you and your partner are having a difficult time getting pregnant, artificial insemination may be the solution you have been searching for. Contact us today to schedule an appointment and learn more. Patient Quick Links Why Choose CFI? Becoming a Recipient of Donor Egg/Embryo Robotic & Minimally Invasive Surgery Ovest – Egg Preservation 4 Virtual Resources for Infertility Support Infertility can be very isolating and lonely for women who …read more » Copyright © 2021 Carolinas Fertility Institute	cc/2021-04/en_middle_0086.json.gz/line1797063
__label__cc	0.566599	0.433401	Africa N'da Blues CD CD, DVD, BLU-RAY lemez, ajándék tárgyak (póló, baseball sapka) könnyż klasszikus film Vissza a kereséshez Africa N'da Blues Kahil El'Zabar's Ritual Trio, Kahil El' Zabar with Malachi Favors, Ari Brown feat. Pharoah Sanders első megjelenés éve: 2000 Kiveszem a kosaramból! 1. Ka-Real 2. Africanos/Latinos 3. Miles' Mode 4. Autumn LEaves 5. Africa N'da Blues 6. Pharoah's Song On Africa N'da Blues, percussionist Kahil El'Zabar writes the next chapter in his continuing study of the music that shaped the future of jazz. His previous Delmark album, Conversations (Delmark 514), brought tenor saxist Archie Shepp into the setting of his Ritual Trio, establishing a cross-generational bridge between that 1960s firebrand and El'Zabar's 20-year-old trio. Now the Ritual Trio featuring bassist Malachi Favors and saxist/pianist Ari Brown, does the same with tenor great Pharaoh Sanders, who like Shepp represents a direct link to the central figure of the avant-garde, John Coltrane. Sanders has experienced an unexpected renaissance in the '90s, but he has rarely sounded as he does here, challenged by three musicians who, while drawing significantly on his influence, are leaders in their own right. Reaction Report: "Africa N'da Blues features three great AACM members, drummer Kahil El'Zabar, bassist Malachi Favors, and saxophonis/pianist Ari Brown, as well as guest saxophonist Pharoah Sanders. With Brown spending most of his time on piano, the music presented here has a classic quartet sound, while the playing, as is often the case with AACM musicians, reflects a deep knowledge of the jazz tradition without losing the adventurous precepts of improvisation. Sanders' sound is particularly lively here, playing with a robust multiphonic tone that recalls his work of the '60s and '70s. El'Zabar pens most of the album's material, but there are also versions of Coletrane's "Miles Mode" and a bop take on the standard "Autumn Leaves." Rating: MUST HEAR." ---CMJ New Music Report	cc/2021-04/en_middle_0086.json.gz/line1797067
__label__cc	0.532076	0.467924	Acadia Pharmaceuticals to Present New Scientific Data on Pimavanserin in Neurodegenerative Diseases at the 13th Clinical Trials on Alzheimer's Disease (CTAD) Conference SAN DIEGO--(BUSINESS WIRE)--Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced that scientific presentations highlighting new analyses of pimavanserin clinical study data in dementia-related psychosis and neurodegenerative diseases will be shared at the 13th Clinical Trials on Alzheimer's Disease Conference (CTAD), being held virtually November 4-7, 2020. Scientific presentations include those investigating pimavanserin treatment and its impact on cognition and motor function in patients with neuropsychiatric symptoms related to neurodegenerative diseases, including dementia-related psychosis. Other presentations include a comprehensive literature review of current use of antipsychotic treatment for dementia-related psychosis, an analysis of mortality risk and need for long-term care for patients with dementia-related psychosis versus patients with dementia only, and assessments of efficacy and safety of pimavanserin in dementia-related psychosis. CTAD Accepted Scientific Presentations include: Oral Presentations: Oral Presentation (OC31): Impact of Pimavanserin on Cognitive Measures in Patients with Neurodegenerative Disease: Results from 4 Placebo-Controlled Clinical Studies on Friday, November 6, 10:45 – 11:00 a.m. ET. Presenting author: Clive Ballard, MBChB, University of Exeter Medical School, Exeter, United Kingdom. Oral Presentation (OC17): Relationship Between Pimavanserin Exposure and Psychosis Relapse in Patients with Dementia-Related Psychosis: Clinical Results and Modeling Analysis from the Phase 3 HARMONY Study on Thursday, November 5, 10:30 – 10:45 a.m. ET. Presenting author: Mona Darwish, Acadia Pharmaceuticals Inc. Poster Presentations: Poster Presentation (P75): Impact of Pimavanserin Treatment on Motor Function in Patients with Neurodegenerative Disease: Results from 3 Clinical Studies. Presenting author: Daniel Weintraub, M.D., Departments of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Poster Presentation (P21): Frequency of Antipsychotic-Associated Adverse Events with Pimavanserin Treatment in Patients with Dementia-Related Psychosis. Presenting author: George Demos, M.D., Acadia Pharmaceuticals Inc. Poster Presentation (P71): Comparative Efficacy, Safety, Tolerability, and Effectiveness of Antipsychotics in the Treatment of Dementia Related Psychosis (DRP): A Systematic Literature Review. Presenting author: Ismaeel Yunusa, An-L-lt-Iks, Inc. Poster Presentation (P69): Mortality Risk and Use of Long-Term Custodial Care for Patients With Dementia and Psychosis Versus Patients With Dementia Only: A Longitudinal, Matched Cohort Analysis of Medicare Claims Data. Presenting author: Nazia Rashid, Acadia Pharmaceuticals Inc. About Pimavanserin Pimavanserin is a selective serotonin inverse agonist and antagonist preferentially targeting 5-HT2A receptors. These receptors are thought to play an important role in neuropsychiatric disorders. In vitro, pimavanserin demonstrated no appreciable binding affinity for dopamine (including D2), histamine, muscarinic, or adrenergic receptors. Pimavanserin was approved for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis by the U.S. Food and Drug Administration in April 2016 under the trade name NUPLAZID®. Acadia submitted a supplemental new drug application (sNDA) for pimavanserin for the treatment of hallucinations and delusions associated with dementia-related psychosis on June 3, 2020. The FDA has accepted for filing the sNDA for DRP with a PDUFA date of April 3, 2021. NUPLAZID is not approved for dementia-related psychosis. In addition, Acadia is developing pimavanserin in other neuropsychiatric conditions. About Acadia Pharmaceuticals Acadia is trailblazing breakthroughs in neuroscience to elevate life through science. For more than 25 years we have been working at the forefront of healthcare to bring vital solutions to people who need them most. We developed and commercialize the first and only approved therapy for hallucinations and delusions associated with Parkinson’s disease psychosis. Our late-stage development efforts are focused on dementia-related psychosis, negative symptoms of schizophrenia and Rett syndrome, and in early-stage clinical research we are exploring novel approaches to pain management, cognition and neuropsychiatric symptoms in central nervous system disorders. For more information, visit us at www.acadia-pharm.com and follow us on LinkedIn. Important Safety Information and Indication for NUPLAZID (pimavanserin) NUPLAZID is indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. NUPLAZID is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis. Contraindication: NUPLAZID is contraindicated in patients with a history of a hypersensitivity reaction to pimavanserin or any of its components. Rash, urticaria, and reactions consistent with angioedema (e.g., tongue swelling, circumoral edema, throat tightness, and dyspnea) have been reported. Warnings and Precautions: QT Interval Prolongation NUPLAZID prolongs the QT interval. The use of NUPLAZID should be avoided in patients with known QT prolongation or in combination with other drugs known to prolong QT interval including Class 1A antiarrhythmics or Class 3 antiarrhythmics, certain antipsychotic medications, and certain antibiotics. NUPLAZID should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and presence of congenital prolongation of the QT interval. Adverse Reactions: The common adverse reactions (≥2% for NUPLAZID and greater than placebo) were peripheral edema (7% vs 2%), nausea (7% vs 4%), confusional state (6% vs 3%), hallucination (5% vs 3%), constipation (4% vs 3%), and gait disturbance (2% vs <1%). Drug Interactions: Coadministration with strong CYP3A4 inhibitors (e.g., ketoconazole) increases NUPLAZID exposure. Reduce NUPLAZID dose to 10 mg taken orally as one tablet once daily. Coadministration with strong or moderate CYP3A4 inducers reduces NUPLAZID exposure. Avoid concomitant use of strong or moderate CYP3A4 inducers with NUPLAZID. Recommended dose: 34 mg capsule taken orally once daily, without titration. NUPLAZID is available as 34 mg capsules and 10 mg tablets. Please read the full Prescribing Information including Boxed WARNING. Acadia Pharmaceuticals Inc. Eric Endicott media@acadia-pharm.com Mark Johnson, CFA ir@acadia-pharm.com	cc/2021-04/en_middle_0086.json.gz/line1797073
__label__cc	0.556819	0.443181	Shannon B. Miles Jaime N. Cage Mehry Mohseni Michele Sacks Lowenstein Elizabeth M. Brown Jamie Learakos Jillian Duggan-Herd Ryan Goulet Steven K. Brumer Maria Spear Jasey Mahon Dana Marie Rueckert David Crosgrove In response to rapidly developing public announcements related to Coronavirus, Cage & Miles can support consults and cases remotely due to our cutting edge technology for all employees and our cloud based firm management system. Our people can work remotely on all facets of client cases. In the unfortunate event that one or more of our people are exposed to the virus, our clients’ work does not need to stop. All client files are uploaded, secured and safely backed up on the cloud. We have contingency plans in place at our two offices to see that correspondence from the court, case professionals, opposing counsel, and service providers gets uploaded to our clients’ secured cloud file so our people can work remotely. We are ready, willing and able to keep your case moving forward during these uncertain times. Please contact us if you have questions about how public announcements affect your case. Please click here for more resources. Update: California Court Orders Destruction of Frozen Embryos By Cage & Miles, LLP In California’s first decision to address the fate of frozen embryos after a couple’s divorce, a state judge in San Francisco on Wednesday ordered the destruction of five embryos after a man challenged his ex-wife’s right to use them. The woman, Mimi C. Lee, a 46-year-old cancer survivor, argued that she would not have another chance to bear biological children. Dr. Lee, an anesthesiologist, discovered she had breast cancer shortly before her 2010 wedding to Mr. Findley, 45, an investment executive. Soon after their marriage, the couple went to a fertility clinic for in-vitro fertilization. At that time, they signed an agreement that the embryos would be thawed and destroyed if they ever divorced. Lee testified during the trial that she thought the agreement was only a consent form that she could later change her mind. But the court did not believe her and described her as evasive and contradictory on the witness stand. Judge Anne-Christine Massullo of San Francisco Superior Court upheld the signed agreement, stating: “Decisions about family and children often are difficult, and can be wrenching when they become disputes,” Judge Massullo wrote. “The policy best suited to ensuring that these disputes are resolved in a clear-eyed manner — unswayed by the turmoil, emotion and accusations that attend to contested proceedings in family court — is to give effect to the intentions of the parties at the time of the decision at issue.” Her ruling is consistent with other rulings across the country. Courts in eleven other states, have made a ruling in post-divorce embryo custody cases. And at least eight of them found in favor of the party who did not want the embryos used. One party’s right not to procreate has generally been upheld over the other’s right to procreate. This has been held even in cases where the couples did not sign an agreement as this couple in this case did. There have been three courts, however, that have ruled in favor of women who argued that their frozen embryos provided their only chance to have biological children. The Lee-Findley dispute was the first case in California to address this issue. California is home to many in-vitro fertilization clinics, with hundreds of thousands of embryos stored throughout the state. Lawyers and doctors are patiently watching to see what precedent this case establishes, especially if it moves to a higher court. Lee has previously indicated that she would appeal the decision if she lost. January 19, 2021 Can Medical Bills Be Discharged Through a Bankruptcy Filing? Read More January 14, 2021 Tips for Co-Parenting While School Is Still Online Read More December 22, 2020 How Does Abandonment in Marriage Affect Divorce Issues? Read More December 3, 2020 Can I Discharge My Child Support Debt Through Bankruptcy? Read More Location 16644 West Bernardo Dr Suite 201, San Diego, CA 92127 Map & Directions [+] 8989 Rio San Diego Drive Suite 160, San Diego, CA 92108 (619) 825-1777 Map & Directions [+]	cc/2021-04/en_middle_0086.json.gz/line1797076
__label__wiki	0.916975	0.916975	Classical Music News Somewhat Delayed Reviews Forthcoming concerts Festivals and masterclasses Giuseppe Pennisi Gerald Fenech Keith Bramich Geoff Pearce Maria Nockin Rachel Gaston Nat Silverman Alice McVeigh John Dante Prevedini Malcolm Miller Ona Jarmalavičiūtė Patrick Maxwell Annabel Atkins Jenna Orkin Anett Fodor Gordon Andrew R Lucas Ball Paul Sarcich string music Profile. A Gold Mine - Roderic Dunnett visits Birmingham to talk to John Joubert See all our sponsored features >> Terrific Energy MIKE WHEELER reviews a recording of Opera North's recent production of Kurt Weill's 'Street Scene' Nottingham missed out on Opera North's regular March visit this year - the Theatre Royal announced its closure the day the week's run was due to start. Fortunately, BBC Radio 3 was at the Grand Theatre, Leeds, UK, on 12 February, to record the company's new production of Kurt Weill's Street Scene, and this was broadcast on 11 April 2020. So, with the help of some production photos and a few brief video clips on ON's Twitter feed, here goes: Opera North has form with Weill. I remember fine productions of Arms and the Cow (Der Kuhhandel) and One Touch of Venus - there was also Love Life, which I didn't get to see. With a cast of over thirty, Street Scene is above all a great ensemble piece, and so played right to Opera North's strengths. A high-water mark of Weill's American career, it is based on Elmer Rice's Pulitzer Prize-winning play of the same title. In what is essentially a tragedy of domestic violence, the motif of unfulfilled longing plays out in a number of cross-cutting story-lines. We see the ethnically mixed inhabitants of a New York tenement block coming and going, interacting, gossiping, coping with life's ups and downs - mostly downs - and trying to stay cool in a stifling heatwave. A publicity photo for Opera North's production of Kurt Weill's Street Scene Central to the scenario are the Maurrants - Anna and Frank, their grown-up daughter Rose and younger son Willie. From left to right: Louis Parker as Willie Maurrant, Giselle Allen as Anna, Alex Banfield as Sam Kaplan, Robert Hayward as Frank and Claire Pascoe as Emma Jones in Opera North's Street Scene In her big Act I number, 'Somehow I Never Could Believe', Giselle Allen balanced the poignancy of Anna's disappointed dreams with a still-flickering belief in a better life. Robert Hayward's Frank was not just a reactionary bully. 'Let Things Be Like They Always Was' gave a glimpse of the pain behind the bluster, the tragedy of someone who simply cannot adjust to a changing world. Of the two would-be lovers, Alex Banfield captured Sam Kaplan's gauche idealism, while avoiding any tendency to self-pity in a powerful account of his solo number 'Lonely House', which Weill said was 'almost a theme song for the show'. Alex Banfield as Sam in 'Lonely House' from Opera North's Street Scene As the more mature of the two, Rose Maurrant is the most developed character, and Gillene Butterfield carried all the role's dramatic weight, vulnerable but also capable of deflecting the predatory advances of her lounge-lizard boss, Harry Easter - Quirijn De Lang somehow managing to suggest he knew he was on to a loser, however hard he drove his chat-up routine in 'Wouldn't You Like To Be On Broadway?'. In 'What Good Would The Moon Be?' Butterfield portrayed both Rose's awareness of her predicament and her uncertainty of the way out. Her final Act I duet with Sam, 'Remember that I Care', was a touching picture of them reaching out to each other but not quite able to connect. Giselle Allen as Anna and Gillene Butterfield as Rose in Opera North's Street Scene The moments of light relief come mainly in Act I. The biggest show-stopper of them all, the song-and-dance number 'Moon-faced, Starry-eyed' actually goes to two of the peripheral characters, Dick McGann and Mae Jones; Rodney Vubya and Michelle Andrews threw themselves into it with terrific energy. Rodney Vubya as Dick McGann and Michelle Andrews as Mae Jones in ‘Moon-Faced, Starry-Eyed’ from Opera North's Street Scene The Opera North Chorus, from which many of the solo roles were cast, was its usual vibrant self, with plenty of emotion in reserve for the unfolding tragedy and its aftermath in Act II. There's a sizeable role for a children's chorus, too, and Opera North's team produced bright, perky accounts of their street game at the start of Act II and, in Act I, 'Wrapped In A Ribbon And Tied In A Bow', as Jennie Hildebrand (Laura Kelly-McInroy) came home from school having won a scholarship to art school (but the family is due to be dispossessed the following day for being unable to pay the rent - it's that sort of show). The children’s street game from Act II of Opera North's Street Scene With conductor James Holmes, the Opera North Orchestra once more demonstrated its ability to morph into a sharp, sassy Broadway pit band. The introduction to Act I set the tone, moving easily from the grinding, abrasive foretaste of 'Lonely Town' at the start, to the tense urgency, then the easy swing, of what followed. The noticeable increase in tension later, when Frank Maurrant first appears, was a small but telling detail. I even fancied I caught curious fleeting echoes of Delius in some of the woodwind solos. (Weill famously made his own orchestrations instead of the usual Broadway practice of farming them out to a resident arranger like Robert Russell Bennett.) Designer Francis O'Connor placed the action inside the tenement as well as on the street outside, on a three-tier set dominated by its huge, impersonal central stairwell. Opera North's Street Scene Delivery of the spoken dialogue sometimes felt just a bit stilted. And the show itself has flaws. Some of Elmer Rice and Langston Hughes' lyrics strike a prosaic note, and occasionally Weill turns in some oddly rushed word-setting. The Act II number for two passing Nursemaids, ghoulishly lapping up the newspaper reports of the tragedy, somehow fails to hit its intended mark. The 'Ice Cream Sextet' in Act I is fun but over-long. The 'Ice Cream Sextet' in Opera North's Street Scene But the work's sheer humanity is big enough to absorb a few wrinkles, and Matthew Eberhardt's production made sure it came across in spades. What a pity it wasn't filmed for streaming - let's hope we don't have to wait too long for the revival. Copyright © 16 April 2020 Mike Wheeler, Derby UK FURTHER INFORMATION: KURT WEILL FURTHER REVIEWS OF OPERA NORTH PRODUCTIONS The Leeds recording of Opera North's production of Kurt Weill's Street Scene is available on BBC Sounds until 11 May 2020. The background image on this page is derived from the September 1942 photo New York, New York. The mall restaurant in Central Park on Sunday by American photojournalist Marjory Collins (1912-1985). << Home Next review >> All material © 1998-2020 Classical Music Daily, various authors and photographers. All rights of the original copyright holders are reserved, and are credited where known. Formerly known as Music & Vision – The world's first daily classical music magazine Founding Editor: Basil Ramsey (1929-2018); Editor: Keith Bramich	cc/2021-04/en_middle_0086.json.gz/line1797087
__label__cc	0.550566	0.449434	Defending Truth and Tradition in the Roman Catholic Church Recent News: Jan. 19, 2021 Most of March for Life is cancelled — LifeSiteNews Trump declares Jan. 22 “Sanctity of Life Day” — LifeSiteNews Cancel culture targets Christians — LifeSiteNews Upstate NY Nursing Home deaths AFTER vaccine–LifeSiteNews ND Republicans push to undermine seal of confession–LifeSiteNews A saner Capitol view — LifeSiteNews Is this what rioting really looks like? — LifeSiteNews FLU shot reported to increase Covid risk about 36%–LifeSiteNews Unborn were alive at tissue extraction — LifeSiteNews COVID Vax gives 1000+ adverse reactions — LifeSiteNews Big %’s of health care ‘front-line’ reject vax — LifeSiteNews Bp. 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And Congress is sorting itself into Nathan Hales or Benedict Arnolds.” Obviously. « Alesi backed by one of his new-found friends Top gay blog laments: ‘WE ALWAYS LOSE’ when voters decide on marriage » Obedience – What It Is, What It Isn’t, and What Others Would Have it Be July 1st, 2011, Promulgated by Gen In recent weeks, there has been a lot of discussion across the internet and in Catholic publications about the troubling situation with Fr. Corapi, who says that he is leaving the priesthood, and yet he is not leaving the Church. Of course, when you take vows to serve the Church, and you openly deny them, the logical conclusion is that, on some level, you are, in fact, leaving the Church. But that’s not the point of this post. Instead, I would like to look at what is actually meant by “obedience.” After all, the Catholic faith is all about obedience, and even those who openly deny their duty to follow Rome will readily profess their fidelity to Christ, even if it is a warped and politicized “fidelity.” One of the oft-encountered qualms here at Cleansing Fire is that we (staffers, writers, readers, etc.) are being disobedient, seeing as how we are to obey the local ordinary (Bishop Clark) in all things. If, in anything, the local ordinary errs, our detractors say that we should remain silent out of respect for the office of “bishop” and its clear and undeniable link with the Apostles. This is a noble and charitable position, at least on the surface of things. And it would be extremely easy merely to abandon this apostolate and let happen what may. But our silence, friends, would be in itself disobedience for the sole reason that the local ordinary is not the final arbiter of Truth. That is, of course, God. And He has chosen to create in His Church one bishopric which rises above others, and which has the authority, privilege, and responsibility to rebuke those who persist in their infidelity. If we were to be obedient on this lower, local level, and merely bite our tongues until the trouble passed, sure . . . maybe we would have done the tactful thing, but would we have done the right thing? Overturning the tables of the money-changers in the temple was certainly not tactful by any stretch of the imagination, but it was a just and noble act, one which showed that obeying the current temporal leaders comes second to obeying the eternal Leader, the King of Kings and Lord of Lords. The following excerpt from Lumen Gentium describes this: 26. A bishop marked with the fullness of the sacrament of Orders, is “the steward of the grace of the supreme priesthood,” (48) especially in the Eucharist, which he offers or causes to be offered,(49) and by which the Church continually lives and grows. This Church of Christ is truly present in all legitimate local congregations (note that by specifying “legitimate, the Second Vatican Council also implies the existence of illegitimate local congregations) of the faithful which, united with their pastors, are themselves called churches in the New Testament.(50) For in their locality these are the new People called by God, in the Holy Spirit and in much fullness.(167) In them the faithful are gathered together by the preaching of the Gospel of Christ, and the mystery of the Lord’s Supper is celebrated, that by the food and blood of the Lord’s body the whole brotherhood may be joined together.(51) In any community of the altar, under the sacred ministry of the bishop,(52) there is exhibited a symbol of that charity and “unity of the mystical Body, without which there can be no salvation.”(One of the major ramifications of Bishop Clark’s reign in Rochester is the fact that this “charity” and “unity” are nowhere to be found. Those who disagree with the Diocese’s agenda, i.e. lay pastoral administrators, lay preachers, etc., are not privy to the same favor shown on those priests and congregations whose loyalties rest in lukewarm adherance to the status quo.) (53) In these communities, though frequently small and poor, or living in the Diaspora, Christ is present, and in virtue of His presence there is brought together one, holy, catholic and apostolic Church.(54) For “the partaking of the body and blood of Christ does nothing other than make us be transformed into that which we consume”. (55) Every legitimate celebration of the Eucharist is regulated by the bishop, to whom is committed the office of offering the worship of Christian religion to the Divine Majesty and of administering it in accordance with the Lord’s commandments and the Church’s laws, as further defined by his particular judgment for his diocese. (And we have all seen what our Bishop “regulates” in terms of sacred liturgy.) Bishops thus, by praying and laboring for the people, make outpourings in many ways and in great abundance from the fullness of Christ’s holiness. By the ministry of the word they communicate God’s power to those who believe unto salvation(168) and through the sacraments, the regular and fruitful distribution of which they regulate by their authority,(56) they sanctify the faithful. They direct the conferring of baptism, by which a sharing in the kingly priesthood of Christ is granted. They are the original ministers of confirmation, dispensers of sacred Orders and the moderators of penitential discipline, and they earnestly exhort and instruct their people to carry out with faith and reverence their part in the liturgy and especially in the holy sacrifice of the Mass. And lastly, by the example of their way of life they must be an influence for good to those over whom they preside, refraining from all evil and, as far as they are able with God’s help, exchanging evil for good, so that together with the flock committed to their care they may arrive at eternal life.(57) 27. Bishops, as vicars and ambassadors of Christ, govern the particular churches entrusted to them (58) by their counsel, exhortations, example, and even by their authority and sacred power, which indeed they use only for the edification of their flock in truth and holiness, remembering that he who is greater should become as the lesser and he who is the chief become as the servant.(169) This power, which they personally exercise in Christ’s name, is proper, ordinary and immediate, although its exercise is ultimately regulated by the supreme authority of the Church, and can be circumscribed by certain limits, for the advantage of the Church or of the faithful. (This is absolutely key. The power and authority of a bishop is essentially irrelevant when this power and authority is directed, not towards the defense of Tradition and Truth, but towards a private desire or personal aim. Bishop Sheen wrote that “the priest is not his own,” but he is Christ’s. The same is true for bishops, but in an even more intense manner! For how can a bishop be acting as Christ, and exercising his God-given authority, when he uses the strength of his office to do more harm than good to those whom he serves? You should note that discussing this is not the same as discussing the man who is bishop, but rather, the office of bishop as lived out by a man.) In virtue of this power, bishops have the sacred right and the duty before the Lord to make laws for their subjects, to pass judgment on them and to moderate everything pertaining to the ordering of worship and the apostolate. The pastoral office or the habitual and daily care of their sheep is entrusted to them completely; nor are they to be regarded as vicars of the Roman Pontiffs, for they exercise an authority that is proper to them, and are quite correctly called “prelates,” heads of the people whom they govern.(59) Their power, therefore, is not destroyed by the supreme and universal power, but on the contrary it is affirmed, strengthened and vindicated by it,(60*) since the Holy Spirit unfailingly preserves the form of government established by Christ the Lord in His Church. For more clarifications on these statements, we can look to a saint whose ties to this Diocese are extremely relevant. St. Thomas More opposed his king and lost his head for it, and yet he is “St.” Thomas More. This man denied lawful authority, citing a higher authority than man’s, and was condemned for treason. However, what is missing from this extremely-abridged story is that St. Thomas More opposed lawful authority, the King of England, Henry VIII, not because it gave him pleasure to do so, but because it was commanded by God through His Church. When Henry VIII broke from Rome, and started persecuting those loyal adherents to the Faith, he lost the obligated respect and obedience of his subjects because he did wrong. Obedience is not owed to anyone who acts in such a way as to transform this Godly obedience into un-Godly disobedience. When St. Thomas More bore silent witness to the true Church, he did so for God’s glory, and not his own glory or edification. Many of those who accuse us of disobedience also accuse us of arrogance, an accusation leveled at St. Thomas More as well. Henry VIII remarked “what is this, that his vanity should be above a king’s?” – and yet, there is no arrogance in obedience, only in disobedience. When we take it upon ourselves to push the envelope, to see how much we can get away with before we get caught, we see the truth of the matter and take such delight in bypassing it for our own satisfaction. Our lay administrators hide behind flimsy reasoning and documentation to be able to preach from the pulpit during Mass, citing documents describing children’s Masses as the basis for preaching at all sorts of Masses. We must not read what we want to into documents, but rather, read them through the lens of obedience. Nothing in the Church ought to be novelty, and yet that is all we see in the Diocese of Rochester, where “norms” are twisted and manipulated to allow all sorts of liturgical mutations which mar the beauty of the Mass and, consequently, the beauty of the souls of the faithful. And whose responsibility is it to prevent against this? It is the Bishop’s responsibility, and the responsibility of his priests. And yet here we are in 2011, where half of our priests are reveling in disobedience and the other half is too afraid to do what is “right and just,” and then there is a small group of faithful priests whose fidelity is rewarded with burdensome assignments, cold-shoulder treatment from the Diocese, and various threats from their “brother priests.” In talking with a priest from Syracuse recently, I was told by him that when he offered a private Mass ad orientem (i.e., alone and at 4 AM in a dark church) he was confronted by the pastor who rebuked him for “praying to a wall” and who threatened violence should he ever see this priest offering an ad orientem liturgy, public or private. This sort of behavior strips the individual, be he a priest or bishop, of his authority. As the lay faithful of the Church, we are obligated not to acquiesce to erring princes, be they temporal leaders or spiritual ones. Bishop Clark is our rightful Bishop. However, this does not mean that he is infallible. Nor is he above rebuke or reproach. He is a man, and capable of mistakes, and as such deserves our prayers and assistance. We do what we do, not as some sort of “gotcha Catholicism,” but as an act of obedience to the Church, and act which, like St. Thomas More’s, may appear to be disobedient, arrogant, or even contemptuous of authority. And yet, it is not! We have a zeal for authority, and it pains us to see it manipulated like it has been in Rochester. A Bishop ought to use his office to do good, and aside from not closing every parish and school in the Diocese, I am hard-pressed to find something I can point to as an undeniable and pure “good” brought about by this administration. So, yes, I acknowledge Bishop Clark to be my Bishop, and I acknowledge the relationship between us as one of prince and steward, but I will not at any point concede that just because the prince is a prince and the steward a steward the prince is infallible. He is not, for he is not the Supreme Pontiff, the Vicar of Christ, the Bishop of Rome. Bishop Clark is a successor to the Apostles, but so too was Arius. Just be thankful that Bishop Clark is not a heretic, but simply a man in need of our fraternal correction and prayers. Remember – your silence gives consent. Tags: Bishop Clark, Orthodoxy at Work, Stop Calling Me a Crypto-Nazi This entry was posted on Friday, July 1st, 2011 at 6:11 PM . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site. 12 Responses to “Obedience – What It Is, What It Isn’t, and What Others Would Have it Be” JLo says: Thank you, Gen. All I wish to add is something Father Groeschel said. He might not have been the first, but he said “Obedience to disobedience is not obedience.” +JMJ Hopefull says: Wonderful presentation, and gives much to think about. Reminds me of the saying: “A priest who isn’t obedient to the liturgy, won’t be obedient to anything.” Anonymous II says: Your position on the above mentioned issues indicate that you are being insubordinate and divisive at the most, and probably heretical at the least. If silence is consent, what has the Vatican criticised openly about Clark?? If they have not publicly censured him, what he does is with their approval. Check the infallibility issue also; you might find that the bishop shares in the infallibility of the Church when he speaks in union with the pope. ” Ex cathedra” usually implies the majority of bishops agreeing with the pope on an issue before the decree is formally published as infallible. See: see history of the Assumption decree. Finally, what do you think the Vatican thinks of your criticism of the man the Pope ( Blessed J-P II) appointed as a bishop??? In many ways you are saying that the pope and the Vatican don’t really have a handle on the performance of the episcopacy in the church. Bishop Clark is NOT speaking in union with the Pope on a plethora of issues. And don’t say he agrees with the homosexuality issue. Making a statement and then, going behind his back, supporting Dignity, suppressing groups who promote the majesterial teachings and not allowing Courage into the diocese speaks volumes of his true feelings. He agrees with Fr. Curran about birth Control. O, he gives lip service to the Pope and nothing more. His whole term of office has been “Lip service” to the Holy Father, and then go behind his back, instituting policies that are opposite to the Holy Father. Anyway, what the bishop supports on these and other issues are not only not infallible, they are easy to refute. The problem in that the bishop has the Bully pulpit in Rochester. Anonymous 84149: Do you really think, with all the people from this blog writing to the Vatican for a very long time, that the Pope is in the dark about all of the things going on in this diocese (see: Spiritus Christi) ? Do you think when the bishop goes to Rome every 5 years for his “ad limina” visit that they just drink tea and talk about whose wiener schnitzel is better? Do you think the pope doesn’t know about the vocation issue here?? Did Clark not just import a bunch of vocations from South America to cover his “butt”? Since this post opened by mentioning Fr. Corapi, it seems an appropriate place to mention today’s post by SOLT, which is more negative toward Fr. Corapi than we’ve seen in earlier releases. Sadly, it makes it seem even harder to keep an open mind about the ultimate outcome, and to pray for a holy resolution. It can be found on a link on Fr. Corapi’s website http://www.blacksheepdog.us to the SOLT site: http://soltnews.blogspot.com/2011/07/press-release-concerning-fr-john-corapi.html Press Release Concerning Fr John Corapi from SOLT Regional Priest Servant From: Rev. Gerard Sheehan, SOLT Regional Priest Servant Society of Our Lady of the Most Holy Trinity Robstown, Texas Fr. John A. Corapi submitted his resignation from the Society of Our Lady of the Most Holy Trinity (“SOLT”) early in June. SOLT is a Society of Apostolic Life of Diocesan Right with its regional office in Robstown, Texas. While SOLT does not typically comment publicly on personnel matters, it recognizes that Fr. John Corapi, through his ministry, has inspired thousands of faithful Catholics, many of whom continue to express their support of him. SOLT also recognizes that Fr. Corapi is now misleading these individuals through his false statements and characterizations. It is for these Catholics that SOLT, by means of this announcement, seeks to set the record straight. A woman, well known to Fr. John Corapi, mailed SOLT a signed letter detailing allegations of Fr. Corapi’s sexual activity with adult women, abuse of alcohol and drugs, improper sacramental practices, violation of his promise of poverty, and other wrongdoing. After receiving the allegation, SOLT formed a three person fact-finding team to ensure that it handled this matter in accordance with canonical norms. The team included a priest-canonist, a psychiatrist, and a lawyer. Two were members of religious orders, and one was a lay Catholic. Two were men, and one was a woman. All three have national reputations and substantial experience in ecclesiastical processes related to priest disciplinary issues. As the Society was engaging this team, Fr. Corapi filed a civil lawsuit against his principal accuser. He contended that she had defamed him and breached her contract. The contract, according to Corapi’s lawsuit, contained a provision binding the woman to silence about him. He offered the woman $100,000 to enter this agreement. SOLT’s fact-finding team subsequently learned that Fr. Corapi may have negotiated contracts with other key witnesses that precluded them from speaking with SOLT’s fact-finding team. Many of these witnesses likely had key information about the accusations being investigated and declined to answer questions and provide documents. When the fact-finding team asked Fr. Corapi to dismiss the lawsuit, to forbear from foreclosing his mortgage, and to release her and other individuals from their contractual obligations to remain silent about him, he refused to do so and, through his canonical advocate, stated: “It is not possible for Father Corapi to answer the Commission’s questions at this time.” SOLT’s fact-finding team has acquired information from Fr. Corapi’s e-mails, various witnesses, and public sources that, together, state that, during his years of public ministry: He did have sexual relations and years of cohabitation (in California and Montana) with a woman known to him, when the relationship began, as a prostitute; He repeatedly abused alcohol and drugs; He has recently engaged in sexting activity with one or more women in Montana; He holds legal title to over $1 million in real estate, numerous luxury vehicles, motorcycles, an ATV, a boat dock, and several motor boats, which is a serious violation of his promise of poverty as a perpetually professed member of the Society. SOLT has contemporaneously with the issuance of this press release directed Fr. John Corapi, under obedience, to return home to the Society’s regional office and take up residence there. It has also ordered him, again under obedience, to dismiss the lawsuit he has filed against his accuser. SOLT’s prior direction to Fr. John Corapi not to engage in any preaching or teaching, the celebration of the sacraments or other public ministry continues. Catholics should understand that SOLT does not consider Fr. John Corapi as fit for ministry. Father Sheehan will not be available for comments as he is attending the SOLT General Chapter from July 5-23. Posted by SOLT Webmaster at 1:58 PM It is only fair to also reprint in its entirety Fr. Corapi’s response today to SOLT’s letter posted above: My Response Regarding Tuesday’s Press Release From SOLT. Posted by The Black SheepDog .I am going to answer in a simple, straight forward way what seem to me the main elements of the action taken against me by the Diocese of Corpus Christi and the Society of Our Lady of the Most Holy Trinity. Regarding my personal financial situation—From the earliest days (more than twenty years ago) the Founder of the Society of Our Lady, Fr. James Flanagan, encouraged me to support myself and the Church as well. He said they could not afford to support my ministry and me personally because of the unique nature of the mission. At every step of the way, through the entire past twenty years, the Society of Our Lady’s leadership knew of my financial independence. As Fr. Flanagan encouraged, I have supported SOLT and myself from ‘day-one.‘ I have never relied on the Society for shelter, clothing, transportation, medical care, or legal counsel and instead, using my history of success in business, set up my mission as any savvy business man would, meanwhile continuing to support the Society and many other Catholic Charities. Regarding the charge of sexual impropriety—This song of greed has been sung many times before. I have never had any promiscuous or even inappropriate relations with her. Never. Regarding the investigation—As standard practice, my legal counsel advised me not to cooperate with the investigation until I was able to determine that the Commission’s process was fair and I had adequate rights to defend myself. Questions that certainly qualify the validity of any legal case have never been answered by the so called “fact finding team.” They refuse to reveal, and therefore utilize, any of the so-called evidence perhaps because if ‘the bad guy’ were truly revealed it may be revealed that he is really not that bad. Clearly, as my legal counsel has portrayed, the evidence supplied by the accused (of which my counsel is not permitted access to) must not have any substance. Regarding ‘hush money’—I never paid anybody off to remain silent. On two occasions there were standard severance agreements executed with former employees and independent contractors. These agreements contained very common non-disclosure provisions. Any attorney who would not include such provisions in such agreements would rightly be guilty of negligent and actionable conduct. Regarding my resignation—I resigned because the process used by the Church is grossly unjust, and, hence, immoral. I resigned because I had no chance from the beginning of a fair and just hearing. As I have indicated from the beginning of all this, I am not extinguished! If I were to commit to the suggestion of the Society, then I would essentially crawl under a rock and wait to die. However, I can not deny this desire to share aspects of Truth and Hope with all those willing to hear. This is what I shall continue to fight for! Many are not going to appreciate this decision, and I respect that. For those who can accept it, onward! Today, July 8, 2011 there is a new video by Fr. Corapi posted on his website http://www.blacksheepdog.us seeming to say in a week or two that he will get on with his new life. No comment is made about whether or not he is pursuing the civil lawsuit mentioned earlier by others as part of his new activities. Mr. Corapi’s getting on into his new life will probably be as a very wealthy layman at least, and excommunicated to boot!! He is following in the footsteps of Episcopal Father Cutie of Miami. Don’t be surprised if he becomes an Episcopal bishop. Beware of these no account televangelists who use the word and gifts of the Lord to line their pockets and sin secretly!!!!!!!! I am posting what seems now to be available, although not officially released, gleaned from some on-line research regarding the sad case involving Fr. Corapi. On November 24, 2009, his email-newsletter stated: “I have recently lost my closest ally and co-worker in the history of my ministry. My God-daughter Tamra traveled well over a million miles with me, worked very hard, and enabled more than 300 events, often the only person working in my office and assisting me. Her husband Matt is mostly responsible for all of the videography and technological growth we have enjoyed. They are moving on to other things, and although my heart is broken at the loss, I can only wish them every blessing for the future. Their hard work and talent blessed millions of souls through the years. Sometimes it is brutally hard to go on, for all of us. Yet, time will go on with us or without us.” Tamra Sexton Sprinkle is apparently the person who has written the letters about Fr. Corapi to the Bishop of Corpus Christi and elsewhere, and also is apparently the person whom he is suing for libel (libel means a lie) and for breach of contract. Both Fr. Corapi and his Santa Cruz media are plaintiffs. I found the redacted charges on line, and although the name is blacked out, it is readable, as are the charges. It was filed on April 4, 2011. The suit identifies the defendant as residing in Kila, Montana. Her Facebook page (picture with husband (Matthew Sprinkle) she married in 2006) is quite interesting. She has over 2600 “Friends” which includes many clergy and religious (bishops, priests, deacons, brothers, sisters). The following bishops (not all Roman Catholic; one avowedly linked to homosexual issues, one “Old Catholic,” a “Reformed Catholic” etc.) are: Bishop Anthony B Taylor, Bishop Anthony Fisher, Bishop Earl L. Frazier, Bishop James V. Johnston, Bishop John Sebastian Lula, Bishop M. Heckman, Bishop Mel Borham, Bishop Paul Andrew Hood, Bishop Peter Ingham, Bishop Renzo Di Venanzo, Bishop Tony Hash. Recently more comments are posted on Tamra’s FB page, obliquely seeming to refer to the situation with Fr. Corapi. Surely someone will cloak these with privacy settings soon, no? But meanwhile, they are readable. Other searches indicate that Tamra and/or her husband is trying to sell Fr. Corapi’s rosary on Ebay for a starting bid of $5,000 and that she may have taken a confusingly similar website name (Blacksheepdog.com, as opposed to Blacksheepdog.us which Fr. Corapi is using,) which dotcom domain has an Ebay starting price of $10,000. I found one other item rather troubling. Earlier, as I read blogs on various people’s opinions about what was really happening, I was disturbed in particular by Jimmy Akin’s (EWTN). To me it seemed not to be even handed, while creating an illusion of fairness. Rather, it seemed to me, IMO, hostile to Fr. Corapi in the way it was written. I was surprised in doing the present research to find him listed as “Friend” on Tamra’s FB page. Raymond Rice says: I think you will find that obedience or lack thereof goes up pretty high in the Church. Recently the Cardinal of Lisbon (Policarpo) stated that there were no theological impediments to ordaining women; which statement is being disobedient to an infallible doctrine promulgated by the pope. I had a disturbing experience today, when I received the Diocesan (email) Courier. There was a Catholic News Service article on Fr. Corapi, covering SOLT’s news release (see stories above.) I almost didn’t read it as I was already familiar with the SOLT release. But I glanced through, and was very surprised to find a different spin on the original SOLT news release. Now I have no opinion (and I’m working to keep it that way) on the Fr. Corapi/SOLT situation, whether Fr. Corapi is right, or SOLT is right, or both or neither are correct, since all the information isn’t yet on the table. But for the CNS to “spin” the facts that are already out there, and the Courier to use the “spun facts,” seems highly inappropriate. Here’s what happened: SOLT’s July 5th announcement can be found at: http://soltnews.blogspot.com/2011/07/press-release-concerning-fr-john-corapi.html and it stated: The CNS story, reprinted by the diocese, can be found at: http://www.catholiccourier.com/news/world-nation/order-accuses-father-corapi-of-sexual-financial-wrongdoing-falsehoods/ and states: “As the team was carrying out its work, Father Corapi filed a civil suit against his principal accuser and then offered $100,000 for her silence, the news release said.” The original CNS story can be found at: http://www.catholicnews.com/data/stories/cns/1102670.htm and states the same as the DoR Courier. (Note: the actual language being discussed is missing from the CNS “briefs” site; it is only on the full story link shown above.) The first quote, from SOLT, shows the possibility that an employee was dismissed, with an agreement to keep all matters of her employment confidential, which is often typical of celebrities, and are “pricey.” However, the CNS story has a word and concept not found in SOLT’s news release: the word “THEN.” It implies that he sued his accuser and THEN offered her $100,000 which would leave open accusations of bribery or tampering with a witness. That would be a vicious accusation, under the guise of supposed reporting. I find it bothersome that DoR would pick up this accusatory “spin” in its Courier. The facts wouldn’t have been that difficult to check out. What is positioned as “News” should be News, with accurate facts. One problem with any blog news is that it can so easily be changed, with revisions undated. But the original SOLT announcement is posted above, and if you received the Diocesan Courier, you can check it out, at: http://www.catholiccourier.com/news/world-nation/order-accuses-father-corapi-of-sexual-financial-wrongdoing-falsehoods/ and the full CNS story is still available at the CNS link. The bigger question is “Who is behind this distortion, and why?” -Return to main page-	cc/2021-04/en_middle_0086.json.gz/line1797088
__label__wiki	0.788148	0.788148	Carolyn Thompson Published: January 13, 2021, 12:09 am Tags: Education Pandemic's toll shows up on students' college applications High school senior Gabriella Staykova poses for a photo at her home in Lexington, Ky., Tuesday, Jan. 5, 2021. As a senior, she planned on visiting college campuses during the last spring break, but with campuses closed due to the pandemic, she is applying to colleges sight unseen. (AP Photo/Timothy D. Easley) In a college application season like no other, students who have seen every aspect of their lives disrupted by the coronavirus are grappling with how to show their potential. High school seniors around the U.S. are facing January and February college application deadlines without SAT and ACT entrance exam scores, community service records and resumes flush with extracurricular activities — all casualties of an era of social distancing and remote learning that has carried over from their junior year. The pandemic has prompted colleges to make tests optional and find new ways to evaluate students, including student-athletes, like southern California high school senior Anthony Correra. The pandemic canceled his last football season, shortening the highlight tapes that he’d hoped to share with college recruiters. “Colleges and universities don’t have the same tools that they did to evaluate students before,” said Angel Perez, chief executive of the National Association for College Admission Counseling, or NACAC. “The experience that students are going through right now is drastically different from many others.” For the first time, the Common Application that allows students to apply to multiple institutions at the same time added an optional space so students can explain in 250 words or less the pandemic’s impacts. A sampling of responses provided to The Associated Press illustrate the pandemic’s academic, emotional and financial toll. “My parents losing their jobs made it very hard financially and we struggled to get by,” a student wrote. “It was already hard before the pandemic but with the low amount of money flowing in as a result of Covid-19’s safe to say our situations got even worse.” Others wrote of struggling to focus alongside siblings and parents in noisy households disrupted by work and school Zoom calls, or of money and technology challenges. “We want to provide colleges with the information they need, with the goal of having students answer COVID-19 questions only once while using the rest of the application as they would have before to share their interests and perspectives beyond COVID-19,” the nonprofit Common Application said. Correra, an all-season athlete at Grand Terrace High School in California, said he hadn’t thought much about college until recently, describing a side effect of life on what he called “quarantine time” where months and milestones pass unremarkably. He has applied to schools in the University of California and California State University systems, as well as some private colleges. The colleges that have shown interest have been understanding because so many students are in the same situation, said his father, Mike Correra. “It’s been kind of refreshing a little bit because I’m not as stressed as I was,” said Mike Correra, who said one coach even viewed his cellphone video from his son’s games. Colleges have been eager to work with applicants amid concerns about enrollment declines and an alarming drop in the number of potential students, particularly low-income students, filling out financial aid documents — an indicator they may not pursue college. Very competitive colleges, though, have had the opposite problem of trying to juggle large numbers of students who deferred acceptance last year on top of increasing applications for the coming year. Harvard College, for one, marked its most competitive early admissions cycle ever, the Harvard Crimson reported. The college invited 747 of 10,086 early applicants to join its Class of 2025, down from 895 of 6,424 applicants last year. More than 1,600 institutions have made it optional for students to submit admissions test scores in an acknowledgement of cancelled testing sessions, Perez said. Instead, admissions officers will lean more heavily on essays, grades and the rigor of coursework, pre-pandemic extracurriculars and more than ever, the interest students show in attending. “Usually this time of year, schools would be all over the country and the world, recruiting. ... But now they’ve moved into this online space where they are seeking individual conversations, interviews, engagement with students and families,” Perez said. “So I would also say to students, raise your hand and reach out individually to an admissions counselor if you’re interested in those institutions.” With in-person interviews difficult, institutions including Washington University in St. Louis and Bowdoin in Maine are inviting students to send videos introducing themselves, a practice that was catching on before the pandemic. Bowdoin this year also said applicants could swap out a usual teacher evaluation with an “other” recommendation from a friend, employer or someone else with insight about their character. But rounding up any kind of letters remotely can be challenging. “It’s definitely preferable to be able to discuss those in person instead of emailing back and forth,” said Claire Gelillo, a high school senior in Rockville, Maryland. “One of the big things is not having the support of peers and teachers as readily available.” Lexington, Kentucky, high school senior Gabriella Staykova had planned to visit several colleges during spring break in her junior year, but with her school shut down since March 13 she is applying for many colleges sight unseen. She crossed Barnard College in New York City off the list and has reservations about others in unfamiliar cities. “I’m just hoping that things will clear up enough before Decision Day that I’ll be able to either tour the schools in person or that the schools will offer some sort of online alternative that’s a lot more personal than what they usually would do,” she said. “That way maybe I can make more educated guesses.”	cc/2021-04/en_middle_0086.json.gz/line1797089
__label__cc	0.671716	0.328284	PUBLIC ACCESS CLOSED - CALL/EMAIL MON-FRI 8:30-4:30 info@venture13.ca V13 Client Login About V13 Policetech Accelerator TechXpo Microfactory Co-Operative Northumberland Makers Accelerator Membership Health Canada Approved Thermal Imaging Technology Used at Cobourg Police Service to Combat COVID-19 Spread Posted on Monday October 19, 2020 Cobourg, ON (October 19th, 2020) - COVID-19 has fundamentally changed the world, but it has also undeniably led to an acceleration of driving new progressive technology. For instance, Cloud computing, AI and Automation is making existing processes – in response to more strained global supply chains – more efficient through digital transformation with newer innovative products and services. Combating the spread of COVID-19, Alex Papanicolaou and Nisha Sarveswaran, rose to the challenge back in May, 2020, and have been working in collaboration with the V13 Policetech Accelerator and the Cobourg Police Service (CPS) on an innovative non-contact smart thermal imaging technology that can accurately measure temperatures in real-time that elicit symptoms of COVID-19 (or other illnesses) called: ThermaScans – app available on Google Play and the iOS “We are grateful to the Town of Cobourg, Northumberland CFDC, FedDev Ontario and the Policetech Accelerator for the opportunity to make a difference for front-line workers,” said Alex Papanicolaou, Co-Founder and CEO of ThermaScans. “The Cobourg Police Service has provided an excellent test bed in a controlled environment to validate the efficacy and efficiency of our technology. The responsiveness and communication with Chief VandeGraaf and Thomas Wilson—as well as the support of Cobourg’s interim CAO Ian Davey and his team—have been integral to the rapid deployment of the ThermaScans system.” The precision of the ThermaScans technology has already led to an early market adoption Canada-wide, and is currently deployed in multiple front-line environments in active use by local municipal and essential services. The Cobourg police station has also installed the innovative technology in its cell block as a means to take temperature readings of individuals during the booking process. "Among the key factors driving new technology are innovation and motivation, but the fundamental driver in our view is digital transformation. ThermaScans' technology assures that individuals are triaged appropriately, preventing further community transmission. By this innovative approach, we are protecting not only the safety of front-line officers, but all the justice system partners," said Paul VandeGraaf, Chief of Police, Cobourg Police Service. "Collective efforts between Northumberland CFDC, CPS, and the V13 Policetech Accelerator is focused at the development and implementation of innovative policing technologies and best practices for community safety in Ontario and around the world." The ThermaScans hardware is proudly designed and made in Northumberland at Canada’s first Microfactory Co-operative, a member of the Northumberland Manufacturers Association. The technology was recently awarded a Class 1 Medical Device Establishment License (MDEL) from Health Canada. For more information on ThermaScans, visit www.thermascans.com. © 2018 Venture13 739 D'Arcy Street (Map) Venture13 brings together early-stage entrepreneurs with our innovation partners to connect, empower and accelerate new ventures. It is a place and a pathway for business growth synchronized with economic development and diversification. Our goal is to partner with many to help build the industries of the future. Our facilities include: the V13 VentureZone, MakerLab and Innovation Commons. On May 17, 2018, we officially opened our doors. Welcome to the Rural Renaissance.	cc/2021-04/en_middle_0086.json.gz/line1797096
__label__cc	0.522534	0.477466	Daxson & Dan Thompson – Echoes In Eternity Individually, these two gentlemen have achieved storied individual success through the Coldharbour prism. So when Daxson and Dan Thompson unite visions for the first time, it’s an occasion to be noticed. They present “Echoes in Eternity”. Both producers form part of the strong array of UK talent that have contributed richly towards the trance scene in recent years, including original outings on the label in 2020 already, in the form of Daxson’s Atomica and Thompson’s Twilight. For Echoes in Eternity, the journey begins with an infectious bassline packed full of punch and groove; gliding towards the melodic touch in which both men excel. An immediate attention grabber, it’s a piece that delightfully heats up the summer nights.	cc/2021-04/en_middle_0086.json.gz/line1797097
__label__wiki	0.927176	0.927176	Here's what we know about coronavirus in Colorado Coloradoan staff Updates within this story are as of March 12. For the latest updates on what we know about COVID-19 in Larimer County, click here. For an FAQ about Colorado's stay-at-home order, click here. To track the latest confirmed cases of coronavirus in Colorado, click here. How many confirmed coronavirus cases are in Colorado? Here are live updates The Coloradoan will track major developments on the virus' spread in the state. Follow along with that coverage here for the latest information. Are school districts, universities and colleges closed? On Wednesday morning, University of Colorado Boulder announced all classes will be moved completely online for the remainder of the semester beginning March 16. Colorado College announced Tuesday all classes would resume online March 30 after an extended spring break at least through mid-April. Colorado State University plans to keep students in the classroom for now. Though CSU officials are preparing for the possibility, there are no plans to close campus buildings or restrict access to campus as of Tuesday afternoon, said Lori Lynn, the co-chair of the university task force responding to COVID-19 and associate executive director of the CSU health network. Poudre School District has cancelled all out-of-state trips for students and staff through April in response to the coronavirus outbreak. Thompson School District has cancelled all district-sponsored trips for students and staff both internationally and to states that have declared a state of emergency. First case announced in Larimer County, woman recovering Larimer County has its first presumptive positive case of the new coronavirus, Colorado health officials announced Monday. A Larimer County resident in her 50s tested positive for COVID-19, based on overnight testing, according to a news release from Colorado Department of Public Health and Environment. She is in isolation at her Johnstown home and fully complying with orders from public health officials. There are two presumptive positive cases in Denver County, three in Douglas County and one case each in Eagle, El Paso and Summit counties, according to data compiled by the health department. At least 5 cases announced on Friday A day after Gov. Jared Polis and Colorado Department of Health officials announced two people in Colorado had tested presumptive positive for the coronavirus, three more counties reported five additional cases, bringing the total to seven. On Friday, Denver health officials confirmed two additional presumptive cases of COVID-19. El Paso County health officials announced another, and Douglas County announced two. In the Denver cases, two residents are symptomatic and isolated but do not currently require hospitalization, Denver Department of Public Health and Environment announced Friday. Both people in those cases had traveled internationally, one on a cruise and one to Vancouver, British Columbia, according to officials. One person is a parent of a student at St. Anne's Episcopal School in Denver, which released students early Friday. Seven individuals who are not currently symptomatic have been or will soon be quarantined, the department said. In El Paso County, a man in his 40s who recently traveled to California tested presumptive positive, according to Dr. Robin Johnson, medical director of the El Paso County Public Health, who spoke at a Friday afternoon news conference. The man is isolated at home in "stable condition." Health workers are investigating his contacts in the community, and some of his family members are under quarantine, Johnson said. He self-reported as soon as he had symptoms and called ahead to limit exposure, she said. Douglas County announced two cases — one in Highlands Ranch and one in Castle Rock — bringing Colorado's total to seven, according to Coloradoan partner 9News. One is an adult who had traveled from Italy. The other is a student who traveled to the Philippines. The student did not attend classes after returning, according to 9News. All seven cases will be tested by the CDC. The map below tracks presumptive positive and confirmed cases of the new coronavirus in Colorado. The map will be updated once daily. Colorado's first 2 coronavirus cases In the first documented case of coronavirus in Colorado, an unidentified person visiting Summit County tested presumptive positive for the virus on Thursday, according to information from Polis and Colorado public health officials. A presumptive positive test result comes after testing at the state level, Polis said in a Thursday afternoon news conference. The results will be sent to the U.S. Centers for Disease Control and Prevention to confirm the test results. The man in his 30s was visiting from from out of state, according to Coloradoan partner 9News. The man had been exposed through travel to Italy, according to Polis. He traveled through Denver International Airport on Feb. 29 but was not experiencing symptoms at that time, Polis said, noting that, according to the CDC, transmission from asymptomatic people is not thought to be the main way the virus spreads. The patient skied at Keystone and Vail Mountain Resort, and the governor's office notified the resorts Thursday. The man developed symptoms March 3, Polis said. He is now at a Jefferson County hospital and recovering in isolation. Three other people he was with while in Colorado have been ordered into quarantine. COVID-19 in Summit County:First two coronavirus cases confirmed in Colorado This content is being provided for free as a public service to our readers during the coronavirus outbreak. Please support local journalism by subscribing to the Coloradoan. In the second case, an elderly Douglas County woman tested presumptive positive for the virus. She had recently returned to Colorado from international travel on a cruise and is isolated at her home, per CDC guidelines, according to a news release. “She is currently isolated at home and has had limited public contact, including with her family members and health care providers. Tri-County Health Department staff is monitoring people who may have been exposed,” said the department's executive director, John M. Douglas Jr., in a news release. “We are hoping that she recovers quickly.” (STORY CONTINUES BELOW) As FDA warns of false negatives with COVID-19 tests, Loveland nursing home cases surge Northern Colorado youth sports find safe haven from COVID-19 rules in Weld County Larimer County and Colorado COVID-19 case, death and hospital data for January 2021 Coronavirus in Colorado: What we know about the new COVID-19 variant strain Are any Fort Collins residents aboard the Grand Princess? Greg and Susan White of Fort Collins reached out to the Coloradoan on Friday, saying they are among thousands of people aboard the Grand Princess cruise ship being held off the coast of California after crew and passengers developed symptoms of the new coronavirus while on board. The Grand Princess had been ordered not to dock in California until tests were concluded on people aboard who had exhibited symptoms or had been on a previous voyage with a 71-year-old man who died from the disease, according to a report from USA Today. On Friday afternoon, Vice President Mike Pence said 46 people aboard the ship had been swabbed. Of those, 21 tested positive for the virus, 24 test was negative and one was inconclusive. Of those that tested positive, 19 were crew members and two were passengers. Pence said crew members would likely be quarantined on the ship and that everyone on the ship would be tested, according to a USA Today report. In a video obtained by USA Today, the ship's captain can be heard saying the people infected on board "will continue to stay quarantined in their staterooms," until they can be transferred to hospitals on shore. Late Friday afternoon, officials announced the ship will dock this weekend in a "non-commercial port." What are coronavirus symptoms? Symptoms of COVID-19 can range from mild to severe; the virus can also be asymptomatic, meaning some people don't have any symptoms at all. The most common symptoms mirror the flu and include fever, tiredness and dry cough. Some people also develop aches and pains, nasal congestion, runny nose, sore throat or diarrhea. About 1 in 6 people becomes seriously ill and develops difficulty breathing, according to the World Health Organization. If you experience fever, cough and shortness of breath, call your doctor. How is coronavirus spread? Will a face mask help? The virus is spreading rapidly from person to person, and scientists are still learning more about how it spreads. According to the CDC, the virus spreads between people who are in close contact with one another (within about 6 feet) and through respiratory droplets, much like the common cold or flu. Coronavirus outbreak in China:How the virus spread so fast There's no evidence that the virus can be transmitted through food, according to the CDC. It is, however, possible that a person can get the virus by touching a surface or object that has the virus on it and then touching their own face. Across the country, people are reaching for face masks. Some stores across the nation are selling out. But infectious-disease experts say a face mask can offer only slight protection against airborne illness. A more effective defense against a virus is washing your hands thoroughly with soap and warm water after using the restroom and before eating. "CDC does not recommend that people who are well wear a facemask to protect themselves from respiratory diseases, including COVID-19," the CDC says. That mask won't help:Face masks offer little protection against coronavirus, flu, experts warn How long does coronavirus stay on a surface? It is possible that a person can get the virus by touching a surface or object that has the virus on it and then touching their own face. There is likely very low risk of spread from food products or packaging that are shipped over a period of days or weeks, according to the CDC. Can cats, dogs or other pets get the coronavirus? The pet dog of a coronavirus patient in Hong Kong tested "weak" positive for COVID-19 and was put in quarantine in late February, but the department said it does not have evidence that pets can be infected with the virus or can be a source of infection to people. Researchers suspect that COVID-19 spread to humans through an animal, but it was not clear what kind of animal transmitted the disease to people. Hong Kong's Agriculture, Fisheries and Conservation Department has advised that all mammalian pets of coronavirus patients should put their pets under quarantine and veterinary surveillance for 14 days. "If there are any changes in the health condition of the pets, advice from veterinarians should be sought as soon as possible," the statement from the department said. When should you self-quarantine? For how long? As the coronavirus outbreak continues, many Americans are preparing to quarantine themselves. The Centers for Disease Control and Prevention has required some U.S. citizens who returned from China to be quarantined for 14 days. But local communities may have reason to respond to "severe" disruptions as the situation evolves, as the CDC said last week. Should there be a quarantine issued by local authorities — or you self-impose one on you and your family — it would be unlikely to go beyond 14 days, which is the expected incubation period. Going into self-quarantine?: Here's a checklist for some items to have on hand How is Northern Colorado preparing for a possible outbreak of COVID-19? UCHealth and Banner health systems have had protocols in place for potential virus outbreaks for years, most notably the H1N1 pandemic in 2009 and the most recent Ebola outbreak in 2014-16. Several school districts are working with the county health department to develop necessary protocols for a potential virus outbreak, and Colorado State University has had protocols in place to protect against this new coronavirus strain since Jan. 14, according to the university website. Preparing for coronavirus:What's being done in Northern Colorado to prepare for COVID-19 Colorado state health officials announced on March 2 that they received resources to complete 160 tests for the new coronavirus per day, with results in 24 hours. As of Thursday, there have been 93 tests for COVID-19 in Colorado since Jan. 23, according to the latest update posted on the Colorado Department of Public Health and Environment's website. Where have coronavirus cases been confirmed in the U.S.? Aside from the cases in Colorado, cases have been confirmed in Arizona, California, Florida, Georgia, Illinois, Massachusetts, Nevada, New Hampshire, New York, New Jersey, North Carolina, Oregon, Rhode Island, Tennessee, Texas, Washington and Wisconsin, according to Johns Hopkins University. The map below (still being updated) shows all confirmed COVID-19 cases in the U.S. For more cases worldwide, check our interactive global coronavirus map. WHERE IS THE VIRUS?:Tracking the spread of coronavirus cases in the US and worldwide	cc/2021-04/en_middle_0086.json.gz/line1797101
__label__cc	0.680169	0.319831	Property Tax Reassessments & Appeals Every three years, the Cook County Assessor's Office reassesses 1.8 million parcels of Cook County property. Property owners have the right to appeal these assessed values if they feel that their property has been overvalued compared to similar properties. You will never be penalized for filing an appeal, your assessments can only go down and it helps the Assessor's Office continue to process more accurate assessments. Learn more about the appeals process below. To get answers to your questions, please contact our office for one-on-one assistance. Assessor's Office Residential Property Appeal Find Comparable Properties Begin an appeal with the Board or Review Board of Review Appeal Reminder Board of Review Appeals Portal Pre-file Board of Review Property Tax Appeals Assessment Calendar and Deadlines Property Tax Appeal Board (PTAB) Schedule Begin an appeal with PTAB Property Tax Reassessments Every three years, residential and commercial properties get re-assessed to determine their fair market value and the percentage of property taxes that should be paid by the owners. Townships in North Suburbs, including Northfield Township, Wheeling Township and Palatine Township, were fully re-assessed in 2019. Residents have 30 days after their reassessment to appeal. These 2019 property assessments are part of what will impact your property tax bill on your the second installment payments this year. Your assessments will not impact your appraisal and are not the same as the sale price of your home. We won’t know what impact your assessments have on the property tax bill until local levies are set for 2020. Northfield Township: Residential Assessment Report \| Residential Assessment Map\| Commercial/Industrial Assessment Report Palatine Township: Residential Assessment Report \| Residential Assessment Map\| Commercial/Industrial Assessment Report Wheeling Township: Residential Assessment Report \| Residential Assessment Map\| Commercial/Industrial Assessment Report The following dates where when each Township was re-assessed: Northfield Township -- May 24, 2019 Wheeling Township -- July 8, 2019 Palatine Township -- August 2, 2019 These townships will be up for re-assessment in 2022. Appealing Property Tax Assessments with the Cook County Assessor's Office Following the re-assessment of each property in a Township, property owners have 30 days to submit an appeal form to the Assessor’s Office. It is important to file an appeal for every assessment period. You will never be penalized, your assessments can only go down and it helps the Assessor's Office continue to process more accurate assessments. Forms can be filed with the Cook County Assessor's Office online, dropped off at their downtown office or delivered via the mail. In order to file an appeal, constituents must provide comparable properties. This can be done via the Cook County Assessor's website, by appointment with your township assessor or by contacting our office. The following dates are open for residents to file an appeal with the Assessor's Office: Palatine Township -- May 5, 2020 to June 10, 2020 Wheeling Township -- May 14, 2020 to June 19, 2020 Northfield Township -- July 23, 2020 to August 28, 2020 Cook County Board of Review In addition to appealing with the Cook County Assessor's Office, property owners may also submit an appeal with the Cook County Board of Review. The Board of Review is a quasi-judicial office, consisting of three elected Commissioners that work independently of the Assessor's Office to impartially review and prepare evidence for property tax assessment appeal cases. Completed appeals are presented to all three Commissioners who together make a final determination. Residents may file a property tax appeals with the Board of Review every year. You will never be penalized, your assessments can only go down and it helps the Assessor's Office continue to process more accurate assessments. During the Board of Review appeal, property owners may contest their assessments based on comparable properties, factual errors in the description of property characteristics, damage caused by natural disaster or demolition, and recent purchase price among other criteria. Forms can be filed with the Cook County Board of Review online, dropped off at their downtown office or delivered via the mail. The following dates are open for residents to file an appeal with the Board of Review: The Board of Review opens for property tax appeals on August 1 and reviews appeals from property owners on a rolling basis by Township. The Board of Review is now accepting pre-registration requests for all townships. Pre-registration allows taxpayers to be notified by the Board of Review of the opening and closing filing periods for their respective townships. Property owners (Non-Attorneys) are also welcome to Pre-file their Board of Review appeals, which allows filers to submit their appeal before each township officially opens. The Pre-file period will end once the respective township is open. The full schedule will be posted following the opening of the Board of Review appeal filing period. All appeals must be submitted before the township closing dates. Click to Learn More About the Property Tax Sale	cc/2021-04/en_middle_0086.json.gz/line1797103
__label__wiki	0.925533	0.925533	"He Doesn't Decide... We the People Do": Trump Denounced for False Election Night Claim of Victory "We must count every vote, and prepare for what's coming," warned one progressive activist. "This is a crucial moment to defend democracy from fascism at home." Jon Queally, staff writer US President Donald Trump pumps his fist after speaking during election night in the East Room of the White House in Washington, DC, early on November 4, 2020. (Photo: Mandel Ngan/AFP via Getty Images) President Donald Trump realized the fears of many political observers Tuesday night by falsely claiming a "big win" in the U.S. presidential election despite many millions of votes yet to be counted and no clear victor even remotely in sight. "He doesn't decide ... we the people do. Forget his nonsense. We will ensure every vote is counted." —MoveOn.org With the battle over crucial electoral college votes still potentially days or even weeks away—and just after Democratic nominee Joe Biden spoke to the nation in a televised address to urge patience for official results—Trump, just before 1:00 am ET, tweeted he would be "making a statement tonight" and then called it "a big WIN!" Moments later, Trump falsely stated "We are up BIG"—even though at the time both the Associated Press and New York Times election desks had Biden up 213 to 174 in their electoral college projections. Trump then unleashed another lie, stating that the Democrats "are trying to STEAL the Election. We will never let them do it. Votes cannot be cast after the Polls are closed!" Twitter immediately slapped a message on the Trump tweets warning that they contained overt misinformation, stating: "Some or all of the content shared in this Tweet is disputed and might be misleading about an election or other civic process." In order for viewers to see the tweets, they would have to click through the warning." Firing back against Trump's brazen misinformation, Biden himself tweeted: "It's not my place or Donald Trump's place to declare the winner of this election. It's the voters' place." In his earlier speech, Biden urged the nation to remain "patient" as all the votes are counted, but added that he was "optimistic about the outcome." "We believe we are on track to win this election," Biden told supporters from his home city of Wilmington, Delaware. "It ain't over until every vote is counted," he said. Grassroots organizers like MoveOn.org said Trump would not get away with it: He doesn’t decide ... we the people do. Forget his nonsense. We will ensure every vote is counted, and once they are counted, we are confident we will win. Democracy will prevail. #CountEveryVote pic.twitter.com/deeqFYo9JD — MoveOn (@MoveOn) November 4, 2020 Trump emerged to supporters after 2:00 pm ET inside the East Room of the White House where he again falsely claimed victory in the election and lied repeatedly by equating the counting of votes with an effort by Democrats to steal the election. "This is a fraud on the American public," Trump asserted, with no evidence whatsoever to support such a claim. "This is an embarrassment to our country," he continued. "We were getting ready to win this election—frankly, we did win this election." The president continued by saying his campaign's "goal now is to ensure—for the good of this nation, and this is a very big moment—this is a major fraud in our nation. We want the law to be used in the proper manner. So we'll be going to the U.S. Supreme Court." "We want all voting to stop," Trump continued, though of course since polls closed in states on Tuesday evening, all voting has already ended. Trump then bizarrely claimed that phantom ballots might somehow appear "at four o'clock in the morning" that would be "added to the list," apparently by Democrats. "As far I'm concerned," Trump said, "we already have won it." "This is a major fraud on our nation ... so we'll going to the US Supreme Court. We want all voting to stop." -- Trump is counting on SCOTUS to help him steal the election pic.twitter.com/MHF60tszkN — Aaron Rupar (@atrupar) November 4, 2020 George Goehl, director of the progressive advocacy group People's Action, was among those issuing immediate rebuke to any effort by Trump or the Republican Party to steal the election or misinform the American people before the tally of every vote is complete. "Count every vote, no matter how long it takes," said Goehl. "Democracy includes us all. Anyone running for office can say whatever they want to, but it's the will of the voters that decides. Donald Trump and Republicans know they're losing and like any cowards would, are doing everything they can to try and steal this election and block our votes and voices. The voters will decide our next president. And once every single vote is counted, the will of the people will be overwhelmingly clear." While progressives and pro-democracy watchdogs for weeks have warned that Trump would try pull such shenanigans on Election Night, in the end it played out much as many reported and predicted it might. For those keeping score: -@jonathanvswan reported Trump would declare victory in this fashion. -Trump denied that he would do that. -Trump then did what Swan reported he would do. https://t.co/2fKZCKimnG — Daniel Strauss (@DanielStrauss4) November 4, 2020 there it is https://t.co/el0IP9b9ho — ryan cooper (@ryanlcooper) November 4, 2020 Who could have predicted that: 1) Voting day totals would favor Trump 2) The mail-in ballots would take longer to count 3) Trump would claim counting votes is election fraud Oh literally everybody. Everybody predicted this. We will count the votes, and we will win. — Ezra Levin (@ezralevin) November 4, 2020 "You are as predictable as you are corrupt," tweeted progressive organizer Kai Newkirk in response to the president's tweet. "All the votes have been cast already. Now they just have to be counted. This is a democratic republic—not a dictatorship. And We the People intend to keep it. Every vote will be counted." Linda Sarsour, co-founder of the advocacy group M Power Change, said Trump's efforts to subvert the election results would not be tolerated for even one moment. "We must count every single vote—period," Sarsour said in a statement late Tuesday night. "We must count every vote, and prepare for what's coming. This is a crucial moment to defend democracy from fascism at home. We are committed to making sure every vote is counted, whether that means us hitting the streets, taking part in massive nonviolent civil disobedience, or showing up in Washington, D.C. ourselves." Donald Trump, Election 2020, Joe Biden	cc/2021-04/en_middle_0086.json.gz/line1797104
__label__cc	0.648563	0.351437	It happened! The 2016 Cubs capped off a historic season with a World Series victory, and along the way they provided fans with memories galore. Here are a few of our favorite moments from 2016: Kyle Hendricks dominating the Dodgers in Game 6 of the NLCS, Jon Lester's walk-off bunt to cap a crazy, comeback, extra-inning win over the Mariners, Jake Arrieta no-hitting the Reds in a 16-0 victory, Kris Bryant racking up 6 RBI against the Reds, Dexter Fowler's leadoff home run in Game 7 of the World Series, David Ross homering in his final regular season game and final World Series at bat, Eleven straight wins between July 31 and August 12, The four-run, ninth-inning comeback in the NLDS finale, Javy Baez's walk-off homer to finish a May sweep of the Nats, and, of course, An epic battle to win Game 7 of the World Series in extras against Cleveland! The Cubs' 2015 season certainly foreshadowed the success they saw in 2016, as we noted here last January. And the additions of John Lackey, Aroldis Chapman, and Mike Montgomery, along with the development of Javier Baez and Willson Contreras, more than made up for not only the departure of Starlin Castro but also the injuries to Kyle Schwarber and Jorge Soler. As the Cubs head into the 2017 season, the bulk of the championship 2016 roster, rotation, and bullpen remain constant. Gone are Chapman, Fowler, Coghlan, Hammel, Wood, and Ross. But Schwarber is back, Wade Davis is the Cubs' new closer, Heyward is hard at work getting his swing back on track, and Jon Jay & Albert Almora will take over in center. Pitchers and catchers report to Sloan Park in Mesa today, and Opening Day is April 2. As long as Theo has recovered from his month-long bender, things look pretty good on the north side. Follow CMN on Twitter! updated at 2:01 AM Posted by RFBleachers 0 comments ▼ February ( 1 )	cc/2021-04/en_middle_0086.json.gz/line1797107
__label__wiki	0.548887	0.548887	Big Tobacco's Playbook for Investing in Marijuana - Part 1 Steven Lachard (Photo via Pixabay) Big tobacco it taking over cannabis! Some say it's a rumor, some say it's a myth. I hate to break it to you, it may be real, folks! The tobacco industry is absolutely investing in the booming cannabis sector, it's just not exactly publicizing it. When it comes to big tobacco and their investments in cannabis, there's no sure bet on what to look for. The tobacco companies thrive on having deep pockets and the veil of secrecy that comes with it. You don't need to take our word for it though, as big tobacco companies have been leaving crumb trails for decades hinting at their playbook and intentions in the space. Part 1 of their play book is to lock up vital intellectual property. From trademarks to patents, tobacco companies are placing their bets and protecting their investments. The Rumor The people's fear that big-tobacco would take over weed goes back longer than you'd think. An article in The New York Times from September 28th, 1969 centered around the rumor that big tobacco was trademarking common street names for cannabis. People were worried that names like "Acapulco Gold" were being taken by the cigarette companies.The article concluded that: "Under the law, no trademarks can be registered for marijuana cigarettes. If future legislation recognizes the drug as salable, probably registrations can be granted for cigarettes made of marijuana." For further clarity, the article mentions that "like all other marks, those for tobacco must first be used in commerce to be eligible for registration." Essentially you can't get a trademark for use on marijuana products because selling marijuana products is illegal. Not Just a Rumor... But what if tobacco companies filed for use of these marks for other, legal products? Apparently, they did. Based on passages from a 295 page report dating to October 11, 1976, titled "A Technological Forecast of the Future Environment and its Effects on the Tobacco Industry," big tobacco companies were doing just that. As seen above in the passage pictured from page 56 of the report, "In fact, some firms have registered trademarks which are taken directly from marijuana street jargon. These tradenames are used currently on little known legal products, but could be switched if and when marijuana is legalized." Even back then, they were anticipating big tobacco's role in the cannabis industry of tomorrow. The report talks about how big tobacco companies "have the land to grow it, the machines to roll it and package it, [and] the distribution system to market it." The Trademark Trend Continues Years after that report, in November of 1993 an internal Philip Morris e-mail shows the company scrambling to defend their registration of a trademark for the name "Marley" in France. Philip Morris needed to respond to claims made by Bob Marley Music Inc. "that PM is denigrating the name of the late Bob Marley, a Jamaican reggae musician..." The Philip Morris memo goes on to say that "coinciding with this is the fact that the issue of legalizing marijuana has once again come to the fore in Europe." Then comes Philip Morris' media statement, which the e-mail says was "drafted by PMI, in conjunction with PM Trademarks." This statement drops a few interesting hints for us: In response to whether or not Philip Morris was preparing for legalized marijuana cigarette sales..."ABSOLUTELY NOT!" The first stage of acceptance is denial... Don't Forget Patents It's not just trademarks in the tool chest to protect intellectual property, it's patents too! To give you some more recent crumbs from the Philip Morris trail, look at U.S. Patent US9115366B2 assigned to Philip Morris Products SA. Filed back in 2006 but not granted until 2015, this patent protects Philip Morris protection over a "system for producing terpenoids in plants." The patent specifically mentions its applications for cannabis: "the glandular trichomes found among others in the Solanaceae (tomato, tobacco, potato, pepper, eggplant, etc.), Asteraceae (sunflower, etc.) and Cannabaceae (eg.Cannabis sativa) families." Fast forward to April of 2017, when we see modern cannabis companies like CannaRoyalty Corp. forming units to "focus on the development and sale of cannabis products with innovative terpene formulations." A quick search in Google Patents, and just a handful more of cannabis-related patents assigned to big tobacco companies shows up including: In 2003, Japan Tobacco was granted U.S. patent US6509352B1 for a cannabinoid receptor modulator. In 2012 China Tobacco was granted Chinese patent CN202566268U for the production of a "ternary composite filter stick containing cannabis-flavored nanometer porous starch granules." Then in 2014, China Tobacco was granted Chinese patent CN204362945U for the production of a "three-component compound filter stick with cannabis sativa seed extracts." To be totally clear, it's not just big tobacco investing in marijuana. It's an all out race to control the components of this industry before it's too late. Biotech companies all over the world are diving into cannabinoid related research. Billionaire Peter Thiel's Founders Fund has put million of dollars into a cannabis private equity fund, Privateer Holdings. Even Warren Buffett is investing in the booming industry. Stay tuned for part 2 of big tobacco's playbook for investing in the marijuana industry, where we'll focus on their strategic acquisitions. In the meantime, be sure to subscribe to one or more of our free newsletters. Also, don't forget to connect with The Daily Marijuana Observer on Facebook, Twitter, and Instagram. Japan Tobacco China Tobacco United Cannabis Corp. Expanding its International Patent Protection CannaRoyalty Launches "The Terpistry" in Collaboration with Dr. Jörg Bohlmann India Globalization Capital Files International Cannabis Therapy Patents Vitality Biopharma Announces Patent Filing for Neural Repair Treatments IGC Files Provisional Cannabis Therapy Patent Apple Files a Vape Patent!	cc/2021-04/en_middle_0086.json.gz/line1797112
__label__cc	0.704592	0.295408	F. A. Z.-The Main Guard: Shooting Stars, School Starter, S-Bahn Driver Good Morning, maybe it has seen the one or the other in his insomnia due to 26 degrees and more in the bedroom in the just ended night and done: the sky and sh 12 August 2020 Wednesday 05:20 maybe it has seen the one or the other in his insomnia due to 26 degrees and more in the bedroom in the just ended night and done: the sky and shooting stars spotted. Because the are seen in large numbers, and from today on morning, once again. So a tip early in the Morning for the next night: Dark location looking for or a night hike. Then you can wish for something. For example, with the start of School, the children in the coming week, all is good flap may. For the first time, children under the Corona to be enrolled-conditions. But, what's next? For example, with the mask of duty? Our colleague has asked around Fritzen, Florentine parents have ever been. Much depends on a press conference the Minister of culture Alexander Lorz, which is scheduled for Friday. We are going to report, even without the shooting stars. Carsten Knop F. A. Z. Twitter On the construction site, in order to go out, one way or the other wishes come true: The four-track Expansion of the previously only two-track railway line between Frankfurt and Bad Vilbel is taken in a few days, a first section in operation. From next Monday to the S-Bahn in the two and a half kilometers between the Frankfurt district of Eschersheim and Frankfurt West station is no longer on the old, but on a separate, additional Track. The first of the two already existing tracks can be out of service and rebuilt, with space for the new S-Bahn-Frankfurt stop point is created Ginnheim, while at the same time, the construction of the fourth track begins. This is for commuters, good news. whether you need to, it is only now, after the holidays, without children go on holiday, back to work or in the home office are allowed to stay: In any case, books are full of sun, beach and water just the Right thing to do. In this context, allow me a note on the values read glosses of our Rhine-Main-Culture editor, which you can find on the final page of our Rhein-Main-Zeitung. There is a piece of Florian Balke, the two book titles that could meet these requirements today, on a very special way. you Can read seduce. F. A. Z.-Newsletter "Hauptwache" So the day begins in Frankfurt and Rhine-Main: the most Important points in brief, with References to mobile speed cameras, road closures, and restaurants. Please take notice of our privacy. And in addition, the Frankfurt public Prosecutor's office on suspicion of tax evasion and money laundering, several objects in the Rhine-Main-area search + + let+ the rest of the passenger figures at Frankfurt airport, only slow +++ would like to wait a Joint Venture of several companies, including the publisher of this newspaper, close to the S-Bahn-Station Gallus, between the Mainzer landstraße and Frankenallee, 650 rental apartments building, of which 30 per cent funded. Also in the quarter, office space to arise, the city is planning a primary school. Many greetings from the editorial team, 1 Interhyp-study: real estate buyers use low interest... 2 GPG submits the application for insolvency: New cases... 3 In the case of vaccine approval: Trump Americans promises... 4 Iris Berben-style-questionnaire: For dinner? Wine!... 5 The death of Ekkehard may: The unforgettable makers... 6 Iris, The woman from the other star will Berben Seventy:... 7 Champions-League-final tournament: The mode will explode... 8 German-Bank-chief: Sewing should be in the spring... 9 Frankfurt airport: Beagle Aki sniffs out 250,000 euros... 10 The drought: the forest-disabling consequences as... Damaging winds and fire Threat in California, wintry blast for East 2 dogs credited with Rescuing owner's Lifetime from burning Dwelling die Exactly the same fire Spirit Representative hospitalized, passengers Detained after Luggage dispute Ohio police officer shot and killed following hours long standoff The inequities of PPP: Megachurches, Big corporations Get money Before small Companies Interhyp-study: real estate buyers use low interest...	cc/2021-04/en_middle_0086.json.gz/line1797113
__label__wiki	0.841176	0.841176	Ticketmaster Developing Plans To Require Negative COVID Test Or Vaccine To Attend Events By Paul Bois Nov 11, 2020 DailyWire.com Scott Eells/Bloomberg via Getty Images Anyone looking to enjoy a concert sponsored by Ticketmaster in the near future may have to present evidence of being vaccinated or a negative COVID-19 test, provided that the event organizer agrees to it. According to Billboard, Ticketmaster began formulating a new framework for 2021 after Pfizer announced that their COVID-19 vaccine had a 90% efficacy rate after the initial clinical trials. “As part of that preparation, Ticketmaster has been working on a framework for post-pandemic fan safety that uses smart phones to verify fans’ vaccination status or whether they’ve tested negative for the coronavirus within a 24 to 72 hour window,” reported the outlet. “Many details of the plan, which is still in development phase, will rely on three separate components – the Ticketmaster digital ticket app, third party health information companies like CLEAR Health Pass or IBM’s Digital Health Pass and testing and vaccine distribution providers like Labcorp and the CVS Minute Clinic,” the report continued. If implemented, the procedure will require customers to present evidence of a COVID-19 vaccination or show that they tested negative for the virus 24 to 72 hours prior to the concert. Regional health authorities would decide the window of time between a negative test and attending the concert; the program will also require the consent of the event organizer. “Once the test was complete, the fan would instruct the lab to deliver the results to their health pass company, like CLEAR or IBM. If the tests were negative, or the fan was vaccinated, the health pass company would verify the attendee’s COVID-19 status to Ticketmaster, which would then issue the fan the credentials needed to access the event,” continued Billboard. “If a fan tested positive or didn’t take a test to verify their status, they would not be granted access to the event. There are still many details to work out, but the goal of the program is for fans to take care of vaccines and testing prior to the concert and not show up hoping to be tested onsite.” Mark Yovich, president of Ticketmaster, told Billboard that third-party verification companies will soon be working to track COVID-19. “We’re already seeing many third-party health care providers prepare to handle the vetting – whether that is getting a vaccine, taking a test, or other methods of review and approval – which could then be linked via a digital ticket so everyone entering the event is verified,” Yovich said. “Ticketmaster’s goal is to provide enough flexibility and options that venues and fans have multiple paths to return to events, and is working to create integrations to our API and leading digital ticketing technology as we will look to tap into the top solutions based on what’s green-lit by officials and desired by clients.” Ticketmaster services most sports leagues and concert venues in the United States. Because Ticketmaster tickets the vast majority of sports leagues in the United States, as well as concert venues and Live Nation owned properties, the implementation of their COVID-19 plan will be an important milestone for the live entertainment industry.	cc/2021-04/en_middle_0086.json.gz/line1797114
__label__cc	0.574445	0.425555	4 Things You Need to Know Before Buying a Diamond Evaluate the four Cs before you make any moves. By Kathy Lee Jeffrey Westbrook/Studio D EARRINGS, Vera Wang Love Collection, zales.com A diamond's cut grade is determined by how well its facets interact with light to create visual effects in both the diamond's interior and its exterior (aka sparkle!). Of all the 4 Cs, cut is the most important factor in how the stone appears to the naked eye. If the cut is too shallow, light will leak out the bottom; too deep, and light will escape from the side. An ideal cut diamond directs light to the bottom of the stone and back up through its top (or what gemologists call the table). It will cost you more but is arguably what makes diamonds so special. NECKLACE, Hearts on Fire, heartsonfire.com Nearly all diamonds have some imperfections. But often, these flaws — called inclusions and blemishes — are microscopic. Diamonds with the fewest and smallest imperfections get a higher clarity grade — and price. RING, Tacori, tacori.com With diamonds, the less color there is, the more light and sparkle and the higher the quality. A D-grade diamond is the top of the color chain, as it has no color at all, while Z is the lowest and most yellow. BRACELET, Phoenix Roze, phoenixroze.com Think of carats like pounds — they measure how much a diamond weighs. A single metric carat is defined as 0.2 grams. For diamond shapes like round, princess, and Asscher, the greater the distance in millimeters across the top of the stone, generally the greater the carat weight. RING, Forevermark by Jade Trau, forevermark.com Wherever you're shopping, the diamond guidelines will be the same: The Gemological Institute of America's 4 Cs is a universal standard used worldwide to judge the quality and pricing of diamonds. This article was originally published as "Bling Buyer's Guide" in the June 2016 issue of Cosmopolitan. More From Beauty & Style Looking at Vintage Ski Pics = Your Winter Staycay 12 Perfumes to Make Valentine's Day 100% Better 25 Super Sweet V-Day Gifts for Mom The Most Iconic Shoe Moments in Movie History These Are the Need-to-Know Jewelry Brands RN Everything You Need to Know Before Buying a Car 11 Things to Know Before You Buy Running Shoes 7 Things You Need to Know Before Buying Car Insurance 7 Things You Need to Know Before Moving In Together 8 Things You Need to Know Before You Go Hiking Is This the Ultimate List of Things You Need to Know Before You Start College?	cc/2021-04/en_middle_0086.json.gz/line1797116
__label__wiki	0.901315	0.901315	Chipping Norton Literary Festival: where readers meet writers PUBLISHED: 10:48 07 April 2014 \| UPDATED: 10:48 07 April 2014 Chipping Norton Literary Festival 2014 April sees the return of the festival packed full of all things wordy, giving you the chance to get up close and personal with your favourite literary figures. Gill Hornby author of The Hive, will appear in conversation with Times columnist India Knight / Photo: Gavin Smith, Camera Press London. Little Brown Book Group Chipping Norton Literary Festival is a four-day celebration of books, reading and writing, with a host of author talks, signings, discussions and workshops. This year’s speakers include television producer John Lloyd, the man behind Spitting Image, Blackadder and QI; crime writers Nicci French, Tania Carver and Mark Billingham; columnists Tim Dowling, Lucy Mangan and India Knight; and novelists Kate Mosse, Joanna Trollope, and Rachel Joyce; as well as Jonathan Aitken, Alan Johnson, Kate Adie, and economist Tim Harford. The festival is now in its third year, and Festival Director Clare Mackintosh believes it’s going from strength to strength. ‘There are lots of literary festivals around,’ she says, ‘but ChipLitFest offers something very special. We bring big names into intimate, local venues, which means audiences benefit from a fantastic, up-close-and-personal atmosphere. We also have a strong focus on the ‘how to’ side of writing, with workshops including writing for radio, becoming a Mills & Boon author, and creating suspense in your novel.’ Writers can even pitch in person to literary agent Carole Blake, in a ‘Dragon Den’ style event for aspiring authors. Rachel Joyce former actress with the RSC, Royal National Theatre and Cheek by Jowl . Written over 20 plays for Radio 4. Now writer of The Unlikely Pilgrimage a Booker Prize nominated book.. CREDIT Geraint Lewis This year ChipLitFest has partnered with BITE, the food festival that has taken the Cotswolds by storm. On Saturday 26 and Sunday 27 April Chipping Norton market square will be filled with food stalls and tasty titbits – perfect for refuelling readers and writers. BITE will also host a conversation with Claudia Roden, who will talk about her life as a food writer and cultural anthropologist. There are free lectures on economics, Italian literature, the animal world and more, from the ‘Very Short Introduction’ series of books published by Oxford University Press, and masses to do for the whole family, including a ‘Meerkat Mayhem’ hunt with prizes from Cotswold Wildlife Park. Children will be delighted by Charlie & Lola’s Lauren Child, Winnie-the-Witch’s Korky Paul, and a puppet show featuring Peter Rabbit. Claudia Roden Chipping Norton Literary Festival takes place between 24 and 27 April 2014, in association with EFG Private Bank. The full programme is available on the festival website www.chiplitfest.com and tickets are on sale now, starting from just £5. Buy online, contact the box office on 01608 642350 or visit The Theatre, Chipping Norton.	cc/2021-04/en_middle_0086.json.gz/line1797117
__label__wiki	0.56511	0.56511	150 British Success Stories: Introducing Great British Brands 2019 Culture / 2 years ago by Clementina Jackson Country & Town House is proud to present the fourth edition of its annual Great British Brands, featuring 150 British success stories. “Great British Brands is our annual digest of what is happening in the world of all things deliciously, beautifully British. We’re still in that slightly strange territory of not quite knowing what Brexit will bring and yet, judging by the resilience, enterprise and sheer doggedness of the best of our luxury goods companies, we feel that somehow they will continue doing the things they do best” – Lucia van der Post, editor Great British Brands is edited by the best-known name in the luxury arena, Lucia van der Post. The 2019 edition takes a more global stance as we enter the year that takes the UK out of the EU, featuring contributors such as Sarah Mower (on where luxury Britain stands in the world), Marigay McKee (on the shifting retail landscape), Charlotte Metcalf (on how heritage brands stay relevant), Stephen Bayley (on the changing nature of luxury), Alice B-B (on Emilia Wickstead, who designed a dress exclusively for the cover) and Emma Crichton-Miller and Nick Curtis (on the artistic names to watch). Great British Brands: The Video from Country & Town House on Vimeo. Great British Brands 2019 Essay Highlights “The more sophisticated you are, the more likely you will prefer simplicity… even austerity. Henry David Thoreau said, ‘Beware of all enterprises that require new clothes’. Thoreau, it must be explained, had his greatest thoughts while living alone in a wood cabin in the forest. If luxury is to do with privilege, then true modern privilege is to indulge in silence, space, fitness, cleanliness, appropriateness, tact and good manners.” – Stephen Bayley “While the future of retail is definitely digital, the future of brands is still physical. It needs to be executed with expert care, fine attention to detail and in a great environment – with particular relevance to the surrounding demographic. All this needs to be supported by a digital content platform that’s attractive enough to draw the client to visit in the first place, and then to keep coming back.” – Marigay McKee “These can be fragile fortunes, vulnerable to the whims of fashion. The danger in tying a brand’s identity too closely to an individual is that, if mistakes are made, it feels more personal than a company letting a customer down, it’s like the best friend they invited into their homes disappointing them.” – Rosamund Unwin “Emilia is a mother of two, a wife and head of a successful fashion empire. She acknowledges the pressure of combining these worlds, while understanding the power of clothes to make the wearer feel sexy but subtle, feminine but in control. And there’s always a curtsey to old-school glamour.” – Alice B-B on Emilia Wickstead “As British businesses come to terms with the implications, opportunities and uncertainty deriving from Britain’s departure from the EU, luxury itself is undergoing its own metamorphosis. Its very essence is changing as our social and cultural norms and expectations evolve at a rapid pace. While it was once perceived as the most expensive or well-known product, today it is about something far more intangible, based on creating an experience that touches the consumer and remains with them, through the product, service and retail environment (both real and virtual). Brands must seek to engage with their audience in new, innovative ways.” – Julia Carrick OBE A 408-page book showcases 150 of its most iconic and innovative British brands, each telling its own extraordinary story – from global players such as Alexander McQueen, Aston Martin and Rolls-Royce to cultural institutions like The Langham and Westminster Abbey to the newer Brands To Watch section, featuring names such as Charabanc, Guinea and Hummingbird. With increased international distribution, including being sent to every British embassy globally through the British government’s GREAT campaign, this issue is set to be the most exciting yet. Find out more about this year’s brands at in our Great British Brands directory. Follow us on Instagram @countryandtownhouse and share your stories on social media using #GreatBritishBrands. Great British Brands comes FREE with the January edition of Country & Town House which hits the newsstand on Wednesday 12th December. The January issue and Great British Brands will be available from Waitrose, WHSmith, selected M&S Stores and over 2,000 independent retailers nationwide.	cc/2021-04/en_middle_0086.json.gz/line1797118
__label__wiki	0.678222	0.678222	About Craft Brewing Business Craft Brewing Business Professional Insight, Unfiltered Packaging & Distribution Webinars & White Papers Bell’s Brewery division breaks ground in Upper Michigan October 16, 2013 Chris Crowell Upper Hand Brewery, a division of Bell’s Brewery Inc., a state of the art craft brewery and bottling facility, broke ground on Friday at the Delta County Airport Renaissance Zone. The expansion is part of a $15 million capital improvement planned by the company. The craft brewery employs more than 200 people and distributes beer over a territory that includes an 18-state area, Puerto Rico and Washington, D.C. Initial plans call for five employees at the Escanaba brewery. “The Upper Peninsula has always had a special place in my heart. And Escanaba has all the resources anyone opening a business would want to have. We look forward to being a part of the Escanaba and Delta County business community” said Larry Bell, president and founder of Bell’s. The construction investment for the new brewery is estimated to be $1.3 million for the 11,500-square foot facility. Bell’s has selected Iron Mountain-based Gundlach Champion Inc. (GCI) as the general contractor on the project. Based in Iron Mountain, GCI has expertise in the construction of commercial, industrial, tribal, educational, healthcare and municipal structures, including wastewater treatment facilities. The proposed brewery plans to produce a variety of beers and ales to be distributed across the UP and adjacent northern states. Bell said he was drawn to the Escanaba area based on its central location and cooperation demonstrated by local units of government and business leaders. Escanaba City Manager Jim O’Toole agreed. “I am incredibly excited to mark the beginning of construction of the new Bell’s Upper Hand Brewery. The development will positively impact the community and will help us to continue to develop assets and resources. Each barrel of beer produced in Escanaba and sold throughout the Midwest will not only help the local economy but it will keep jobs in Escanaba. I thank all the partners who helped make this project a reality and look forward to a prosperous future for the company.” Upper Hand Brewery to distribute in Wisconsin Bell’s Brewery to open new location, division Bell’s Brewery earns ENERGY STAR Challenge award; let’s detail its sustainability efforts Watch: Relax with a beer and digitally enjoy Bell’s Brewery’s Kalamazoo, Mich., beer garden How Virginia Beer Co. used the shutdown to overhaul its facility (and keep people employed) Craft Malt Conference goes virtual in February, here’s the agenda Firestone Walker just added a massive solar array and canopy on site INDEVCO Plastics debuts 50 percent postconsumer recycled shrink wrap for beverage packaging Clean air, clean beer: New Ingersoll Rand oil-less reciprocating air compressors are ideal for breweries (aeration to canning) Non-alcoholic beer brand Athletic Brewing closes $17M+ in funding with famous backers, selects Crafted ERP, eyes big growth Watch: This awareness video on human trafficking from beer wholesaler Markstein Sales will move you to action Distribution updates: Massachusetts brewers celebrate franchise reform, Yuengling goes to Texas with Molson Coors and more from Bell’s, Stone and beyond Why you need to maximize engagement during a pandemic Advertise on Craft Brewing Business Media Kit Download © 2021 · CBB Media LLC Continue ...	cc/2021-04/en_middle_0086.json.gz/line1797122
__label__wiki	0.859504	0.859504	Hospital board approves sale of property to Northwest Colorado Health Sasha Nelson snelson@craigdailypress.com Memorial Regional Health Board of Trustees have cleared the way for Northwest Colorado Health to purchase the building it has leased at 745 Russell St. CRAIG — The Board of Trustees at Memorial Regional Health has authorized CEO Andy Daniels to enter into an agreement with lease-holders Northwest Colorado Health to sell the building at 745 Russell St. for $690,000. “This was a difficult decision,” said MRH CEO Andy Daniels. “Although we have an immediate need for additional space, the decision was made in what we thought best served the community.” As part of a master site planning process in 2016, comprehensive mechanical, electrical and plumbing evaluations were made of the Russell Street property, which is currently home to MRH Medical Clinic, the VA Clinic and Northwest Colorado Health. Reports showed that most of the building should be vacated and demolished, with the exception of the newest part of the Russell Street property — a standalone structure built in 1996 that is connected to the old hospital — that has been leased to NWCH for many years. “We notified NWCH in April that we were not going to auto-renew the existing lease as part of our master site planning needs,” Daniels said. “Although this building was originally built and paid for by the hospital, we wanted to be sensitive to the needs of the community by giving NWCH the opportunity to purchase this building.” Northwest Colorado Health’s Board of Directors submitted a letter of intent to MRH to begin a review of the building. “As a longtime renter of this space, a purchase would allow our organization longterm stability through ownership. Having a year-to-year lease always offers a risk of relocation,” said NWCH Executive Director Lisa Brown. Ownership would also provide greater flexibility in designing and upgrading the space. Brown said that, as owner, NWCH would “invest in upgrades that will benefit our ability to continue providing our award-winning care in partnership with patients and community.” MRH will now formally request that the Moffat County Board of County Commissioners pass a resolution to allow the sale. “All property purchased by the hospital is titled in the name of Moffat County. By statute, a county hospital cannot take title to property. This is why we have to involve the commissioners,” said MRH Vice President of Operations Jennifer Riley. In the meantime, NWCH will continue the process of evaluating and negotiating the purchase, including seeking financing. “We are optimistic that we will be able to reach a mutually favorable agreement for this transaction,” Brown said. Contact Sasha Nelson at 970-875-1794 or snelson@CraigDailyPress.com. While the state of Colorado will receive much less in vaccines in the second major rollout than expected, Moffat County continues to roll along vaccinating community members with the Moderna COVID-19 vaccine. What you should know about the COVID-19 vaccine Colorado is about to change its coronavirus vaccine priority list — again Program offers free cervical cancer screenings – Early detection saves lives	cc/2021-04/en_middle_0086.json.gz/line1797124
__label__cc	0.721577	0.278423	Drafts, Head East Salon, Functionally Fit get B3 grants Mike Christopherson mchristopherson@crookstontimes.com The B3 (Building Better Business) grant program launched by CHEDA a couple years ago continues to remain popular, with the CHEDA Board this week approving a trio of B3 grant requests, for Drafts Bar & Grill, Head East Salon, and Functionally Fit. With all three of the recipients having to dramatically scale back their operations or entirely shut down for around two months due to stay-at-home orders resulting from the COVID-19 pandemic, CHEDA Executive Director Craig Hoiseth noted that it’s likely local business owners, especially those impacted most by the pandemic, are taking these strange times as an opportunity to improve their business and enhance their amenities and flexibility on the fly when it comes to serving their customers. By approving the three grants, which total $12,000, Hoiseth told his board that the B3 fund has a remaining balance of $17,000. With more local business owners considering B3 grant requests but not yet officially turning in their application, he hinted that the fund might need to be replenished. B3 seeks to improve local businesses by offering grants of up to $5,000. That maximum can be met if the applicants are Crookston High School, University of Minnesota Crookston or Northland Community and Technical College graduates. Businesses can receive a maximum of two B3 grants during the life of the program, and the maximum amount for a second grant is $3,000. Successful applicants must also invest a percentage of their own dollars with each project, and if a granted business ceases to operate within two years of being funded, it must pay back at least half of the grant. Also, if a project is not completed within six months of being funded, 100% of the funds must be returned. The CHEDA Board recently tweaked how funds are dispersed as well. Instead of simply giving a grant recipient a check for their grant amount up front, now grant recipients turn their project invoices in to CHEDA to be paid. The latest trio of grants • Drafts: Owners Brent and Jasmine Melsa, since its their second B3 grant – the first grant allowed them to better equip their food truck – will receive $3,000. The money will be spent on improvements to Drafts’ exterior, which will include fencing around the south and west side of the patio area. Exterior lighting will be added along with umbrellas and a gas fire pit in the patio area. Inside, a new booth will be added and one will be repaired. The total project cost is $6,536.90. • Head East Salon: The salon owned by Kari Trudeau is located at 515 East Robert Street. Trudeau, a CHS and NCTC graduate, will receive the maximum $5,000 that will be applied to her total project cost of $22,632 for new flooring inside and new siding and windows for the exterior. Hoiseth noted that Head East Salon is located on a busy “gateway” coming into Crookston, and it will be nice for the building to get an exterior “dress-up.” • Functionally Fit: Owners Christel and Pete Vigness will receive $4,000. Christel is an NCTC graduate who started the business in her garage, expanded to Valley Technology Park in 2015, and then, in 2016, with an IRP loan from the City of Crookston, bought the JJs Bodyshop building on North Main to relocate her business. The total project cost is $8,700, and Vigness is looking to pave the exterior area outside the fitness center to increase outdoor “boot camp” and fitness opportunities for both youth and adults. She has also recently removed some outdated equipment and is looking to buy some new equipment, including a “step mill.” The paved portion outside would bump up against the paved City-owned lot on the corner. © 2021 www.crookstontimes.com. All rights reserved.	cc/2021-04/en_middle_0086.json.gz/line1797127
__label__wiki	0.666259	0.666259	Tetsworth, Oxfordshire OX9 7AD 100% RESERVED Fill in your details below and we'll be sure to keep you up-to-date with all the latest on this development By registering with Croudace, I agree and consent to Croudace to process my details, My details will be processed in accordance with the Croudace Terms of Use and Privacy statement. Your Registration has been Successful. The Grange is a superb development of 2, 3, 4 and 5 bedroom homes in Tetsworth. Our Marketing Suite is now open by appointment only. Please contact our Sales Consultants to find out more. Coronavirus Customer Notice Nestled south of Thame, Tetsworth is close to breathtaking landscapes and fantastic commuter links. Oxford and Aylesbury are easily reached via the M40, while Haddenham and Thame Park Station has train services to London Marylebone, Oxford and Banbury. The Oxford Tube coach runs from nearby Lewknor and runs a service into Central London every 15 minutes. Please note: the A40 is closed for 25 weeks from 22nd June. Please follow the signed diversion route via Thame for access to Tetsworth. Download our Development Brochure The Burford 5 Bedrooms SOLD Large fitted Kitchen/Family Area with integrated appliances Separate Dining, Living Room, Study, Utility and Cloakroom Double Garage and Driveway The Richmond Fitted Kitchen/Breakfast Room with integrated appliances Separate Dining Room and Living Room The Stanford Large Kitchen/Dining Area 2 Bedrooms with En Suite and Fitted Wardrobes Utility, Cloakroom and Double Garage with internal access It’s a short walk from The Grange into the centre of Tetsworth village, which benefits from a traditional green, a pub, a local shop and a village social club. Tetsworth is in the east of Oxfordshire, just three miles from the beautiful market town of Thame and under 10 miles from the Chiltern Hills, a designated ‘Area of Outstanding Beauty’ since 1965. One of the most picturesque areas in the country, The Chilterns cover a total area of 322 miles. There are several walks and cycle routes through the area, providing excellent opportunities to exploring the Oxfordshire countryside. Places of interest near The Grange include Waddesdon Manor, built for Baron Ferdinand de Rothschild in the 1870s to display his vast collection of objects and works of art, the preserved Chinnor & Princes Risborough Heritage Railway, and Waterperry Gardens, 8 acres of beautifully landscaped ornamental gardens, which also features a quality garden centre, gallery and gift shop, museum and tea shop.	cc/2021-04/en_middle_0086.json.gz/line1797128
__label__wiki	0.644814	0.644814	Iceland - Greenland - Faroe Islands Cruise Ports Isle of Man (Peel-Douglas, UK) Cruise Port schedule, live map, terminals, news Port Map Isle of Man (aka Mann) is one of the UK (British Crown) dependencies - together with the Channle Islands Guernsey and Jersey. As such, Jersey is independently administered and is not part of either the UK or the British Overseas Territories. Like Guernsey, Man Island is located in Irish Sea, between Northern Ireland and England. The island covers a total area of 572 km2 (221 ml2) and has population around 85,000. Its capital is Douglas - port town located on the southeastern coast. Queen Elizabeth II is the head of state. She holds the title "Lord of Mann" and is represented by Lieutenant Governor. Defence and foreign relations are responsibility of the UK Government. Isle of Man is a low-tax economy with no wealth tax, stamp duty, inheritance tax or capital gains tax, and a top rate of income tax of 20%. Its rate of corporation tax is 0% for almost any type of income, with only exceptions the profits of banks (taxed at 10%), and rental (or other) income from land/buildings situated on the island. Offshore banking, tourism and manufacturing are the key sectors of the local economy. In 2016, Isle of Man became the world's first entire country designated "UNESCO Biosphere Reserve". In 2016, Port Douglas handled a total of 16 ship calls. In 2017, the number jumped to 28 - port's ever highest, and 75% increase over 2016. The number of cruise ship tourists grew by over 115% (to 11,500 passengers and crew). In 2018, the island was visited by 24 cruise ships and nearly 8,400 passengers (20% increase over 2017) plus 6,000 crew. The list of recent first-comer cruise lines to the island includes Grand Circle Travel (in 2016, with MV Clio / Tere Moana) and Tauck (in 2017 with the chartered CDP Ponant superyacht Le Soleal). In 2017, the island was included as one of the "surprise port destinations" on MV Hebridean Princess (built as RMS Columba in 1964). In July 2006, this top-luxury cruise ship was chartered by HM Queen Elizabeth II for a royal family cruise around the Scottish Islands, celebrating her 80th birthday. In 2019, the cruise port had scheduled 50 ship calls, including the maiden visits of Hanseatic Nature, Corinthian, Variety Voyager, Ocean Endeavor, Seven Seas Navigator, Ocean Majesty, Serenissima. In March 2018 started construction works on the new cruise berth in Port Douglas. By this project (budged GBP 11 million) will be built a 240-m / 787-ft long deepwater berth on Victoria Pier's outer side. The new pier is part of a 3-year harbour development program, which also includes: (GBP 14,83 million) Kind Edward VIII Pier upgrades (GBP 17, 22 million) building windfarm support ship pontoons, new breakwater, revetment (GBP 6,98 million) constructing a slip (for pleasure boats) plus holding area (GBP 15,55 million) tankership berth upgrade (GBP 10,56 million) Victoria Pier RoRo berth upgrade (GBP 4,23 million) building new cruise tender berth (serving ship's tender boats) Currently, cruise ships anchor in Douglas Bay and transfer their passengers via tenders. The island has been inhabited since before 6500 BC. In the 5th century started the Gaelic cultural influence and Manx language (branch of Gaelic languages) emerged. Edwin of Northumbria conquered the island in 627 AD. During the 9th century, the "Kingdom of the Isles" was established by Norsemen. In the period 1099-11003, the King of Norway, Magnus III, was also known as "King of Mann and the Isles". In 1266, the island became part of Scotland by Treaty of Perth, after being part of Norway. Following a period of alternating rule by the kings of England and Scotland, in 1399 it came under feudal lordship of the English Crown (British Crown since 1765). However, this territory never became part of UK, retaining its status of self-governing British dependency. The annual "Isle of Man TT" ("Tourist Trophy") is a motorcycle race run on the island in May-June. The 2-week event (1 for practice, 1 for racing) is on time-trial basis and held on public roads. Isle of Man cruise terminal Cruise ships to Isle of Man dock (anchor) at Douglas - port town and island's capital (largest town) located on the southeastern coast. Since 2017, Port Douglas offers more island excursions and services, including shipboard promo-marketing brochures and pre-arrival video materials. The number of passenger welcoming volunteers and qualified tour guides was increased. Some smaller ships may alternatively anchor / dock at Peel - port town on the western coast. Isle of Man Sea Terminal in Douglas serves frequent and regularly-scheduled ferries to/from Heysham, as well as summer ferries to/from Liverpool, with a more restricted timetable in winter. Limited (summer-only) ferry crossings are available to/from Dublin and Belfast. In 2018, in Douglas Harbour was built a new, 240-m (787-ft) long deep-water berth, at project cost ~GBP 11 million (EUR 12,5 m). There are port expansion plans for developing a deepwater berth (at Port Douglas) with capacity to handle world's largest liners. If approved, the new facility could be completed and operational by 2023. (NEW) Isle of Man Ferry Terminal in Liverpool In September 2018 were announced Port Liverpool's plans to build a new "Isle of Man Ferry Terminal" at Princes Half-Tide Dock. The facility is located approx 700 m (2200 ft) from the current Pier Head berth at Princes Half-Tide Dock (within Liverpool Waters and Peel Land). The existing Pier Head terminal will be reconstructed into a dedicated cruise terminal as part of the Liverpool Waterfront development project (budgeted GBP 5 billion / EUR 5,6 billion). The new passenger terminal costs GBP 36,5 million (EUR 40,6 M). Funding was subject to Tynwald approval. Project's initial cost was GBP 30 M, which increased due to additional structural and construction works - on the site and the quay walls. Ferry terminal's max capacity is 1000 passengers and 200 vehicles. The inauguration is planned for March 2021. Wheeled freight and passenger vehicles will be served by a new link road (project cost GBP 7,6 million / EUR 8,5 million). In late-October 2018 were released new terminal's building and infrastructure designs. On April 9, 2019, the new ferry terminal project was approved by the Manx Government, which signed a long-term leasehold agreement with Peel Ports for the site. This was the first time when the Isle of Man Government became a UK property owner. Port Isle of Man cruise ship schedule shows timetable calendars of all arrival and departure dates by month. The port's schedule lists all ships (in links) with cruises going to or leaving from Isle of Man, Peel-Douglas, UK. To see the full itineraries (ports of call dates and arrival / departure times) and their lowest rates – just follow the corresponding ship-link. 2020 August2020 September2020 October2021 April2021 May2021 June2021 July2021 August2021 September2022 May2022 June2022 July2022 August2022 September MS Maud Booking.comBooking.com Hurtigruten introduces year-round cruises from Dover UK in 2021 The Norwegian ferry and cruise shipping company Hurtigruten will use Port Dover England as homeport / roundtrip departure port for 4 itineraries in... Plans Approved for New Liverpool Cruise Terminal The long-discussed plans for the new Liverpool Cruise Terminal were finally approved. The facility will be located within Peel L&P's GBP 5... GBP 38 Million Funding Approved for Isle of Man Ferry Terminal Manx government funding was approved for a GBP 38 million passenger ferry terminal in Liverpool despite costs growing by over 1/5. The project, that... Plans Approved for New Isle of Man Ferry Terminal Construction of Isle of Man Ferry Terminal in Liverpool UK can start in the summer of 2019 after planning approval was confirmed today, April 9... VIDEO: Proposed Isle of Man Ferry Terminal in Liverpool Artists' impressions of the new £30 million ferry terminal due to connect Liverpool and Isle of Man were revealed. Manx government released the... New Ferry Terminal to Be Built in Liverpool The New Isle of Man ferry terminal, which is subject to final approval, will be built at Liverpool's Princes Half-Tide Dock. The new Isle of Man... GBP 11 million Cruise Ship Berth to Be Built in Douglas Construction of a GBP 11 million, 240-meter long deep water cruise berth on the outer side of extended Victoria Pier, Isle of Man (Douglas, UK... 70 KG Cannabis Discovered on Isle of Man Ferry A man was charged with drugs offences as cannabis with street value of GBP 440,000 was found in a vehicle on Isle of Man ferry. The man, 30-year... Isle of Man - user reviews and comments 2229 CRUISE PORTS BY REGION Africa - Indian Ocean Islands81 Amazon River7 Arctic - Antarctica79 Asia Rivers80 Australia - New Zealand - Pacific Ocean Islands186 Bahamas - Caribbean - Bermuda145 Baltic - Norwegian Fjords - Russia161 Canada and USA Rivers83 East Coast USA and Canada New England65 Europe Rivers295 France Rivers85 Galapagos Islands20 Hawaii - Mexico - Panama Canal45 Iceland - Greenland - Faroe Islands46 Ireland - UK - British Isles111 Mediterranean - Black Sea258 Nile River14 Russia Rivers30 South America68 West Coast USA and Canada26 Western Europe - Azores - Canary Islands55	cc/2021-04/en_middle_0086.json.gz/line1797129
__label__wiki	0.921327	0.921327	Russia negotiating more arm sales to Balkan ally Serbia By: Dusan Stojanovic, The Associated Press December 21, 2017 A Serbian Army Mi-171 helicopter performs during an exercise at a ceremony marking 72 years since the end of WWII, at Nikinci training ground, 60 kilometers west of Belgrade, Serbia. (Darko Vojinovic/AP) BELGRADE, Serbia — Serbia is negotiating the purchase of military helicopters from Russia, part of an arms delivery that has the potential to heighten tensions in the Balkans and increase Moscow’s influence in the region. Serbian Defence Minister Aleksandar Vulin told the country’s state TV on Thursday that the “high level of military cooperation” between the two countries was agreed between Russian President Vladimir Putin and Serbian President Aleksandar Vucic during his visit to Moscow this week. Vulin said Serbia wants to buy six Mi-17 helicopters as well as form an overhaul base for the Russian choppers, which in effect would give Russian military personnel a presence in the region. He said that close military and other ties with Russia have “significantly changed and strengthened” Serbia’s position internationally. In October, the Serbian Air Force received six MiG-29 fighter jets from Russia, which has also promised the delivery of 30 battle tanks and 30 armored vehicles to Serbia, which was at war with neighbors Croatia, Bosnia and Kosovo in the 1990s during the bloody breakup of the former Yugoslavia. Apart from that, Serbia and Russia are discussing supplies of Buk-M1 and Buk-M2 missile systems. Serbia is also negotiating the delivery of six additional MiG-29s and air defense systems (possibly the S-300) from Belarus. Serbia has been on the path to join the European Union, but under pressure from Moscow, Belgrade has steadily slid toward the Kremlin and its goal of keeping the countries in the region out of NATO and other Western bodies. Serbia, which claims military neutrality, is a member of NATO’s outreach Partnership for Peace program and has held military exercises with both the Russians and the Western military alliance. Hensoldt buys Austrian AI specialist Sail Labs to boost its sensor-fusion portfolio Turkey charges six with selling secret info about defense programs Turkey reports nearly 15% drop in defense exports American warship, F-35 jets to deploy with British fleet French Army orders 364 Serval armored vehicles	cc/2021-04/en_middle_0086.json.gz/line1797130
__label__cc	0.622821	0.377179	Pentagon comptroller: Using the audit to drive change By: David Norquist December 10, 2017 An underreported but long-awaited event begins at the Pentagon this month: Over 20 years after enactment of a law requiring the audit of federal agencies, the U.S. Department of Defense commenced its first full-scope financial statement audit. For years, Congress has been adamant that it is high time for the DoD to go under audit. Under President Donald Trump and Secretary Jim Mattis’ leadership, the process has already begun. As Deputy Secretary of Defense Patrick Shanahan observed: “We have asked the American taxpayers to entrust us with over $600 billion each year. We should welcome the accountability.” Outlook 2018: Perspectives from global thought leaders Accountability is what will drive us — getting the maximum value from every dollar entrusted to us. But auditing the Department of Defense is not a small matter. The consolidated DoD audit will be among the most complicated audits ever conducted, composed of 24 individual audits and an overarching DoD-consolidated audit. With over $2 trillion in assets and nearly 3 million employees, this is the biggest audit in history. A full-scope audit is more than an investigation into accounting and financial record keeping. It will reach into every corner of the department. Many auditors are already at work. By spring, we will have over 1,200 auditors inspecting the Department of Defense from book to floor and floor to book. A book-to-floor inspection means that items reported on the accountable property system of record exist. A floor-to-book inspection means that items that exist have been recorded in that system of record. For example, if the Army is managing munitions at a munitions center, auditors should be able to clearly reconcile those munitions listed in the Army’s system of record with those munitions actually on hand. Our financial transactions and records will be thoroughly reviewed, and our inventories and accounting will be scrutinized. Deputy Secretary Shanahan has challenged our leadership to make a priority of correcting problems identified in the audits. Being under audit will be our new normal at the DoD, an annual event with ongoing remediation and measured results. Although I do not anticipate a clean opinion initially, I do anticipate that the audit will help us to improve our financial management processes and direct our efforts to the highest-priority areas. Our leaders won’t need to guess whether a corrective action plan worked. During a subsequent audit, an independent public accounting firm will review the change and recheck the data. We will have independent confirmation. This allows leaders to improve processes and confidently move onto new issues, keeping the department on track as it moves toward a clean audit opinion. Our goal is to get closer to that opinion by resolving issues each and every year. Because being audited is the DoD’s new normal, our new normal for business systems will evolve. We need systems that are auditable and data structures that comply with current accounting requirements. That may mean some new needs and expectations for business systems so that we can move away from workarounds and manual data calls. Over time we will have a steady improvement in the accuracy and reliability of our business data. This is useful. However, it is the power of modern data analytics that will make this new information revolutionary. You have seen these changes in the private sector where audited and reliable data is the norm. The audit will drive the changes in data that are key to many of our reform initiatives. In the end, it will be the combination of strong leadership, a professional workforce and trustworthy data resulting from audits that will help the department perform its most important mission: direct and timely support to our war-fighting soldiers, sailors, airmen and Marines. David Norquist is the U.S. Defense Department’s comptroller and chief financial officer. Even a pandemic can’t stunt geopolitics NATO secretary general: Our alliance must remain strong militarily and politically across the globe Japan’s defense minister: Transform the defense industry to meet future threats UK defense secretary: Britain is paving a path for modernization and appropriate funding Italy’s defense minister: The future of European defense must involve the United States	cc/2021-04/en_middle_0086.json.gz/line1797131
__label__wiki	0.764229	0.764229	Nalu makes waves with new Rehoboth location Taylor Goebel The Daily Times If you enjoy drinking out of a pineapple and chowing down on authentic Hawaiian fare, you should try the new tiki-fringed Nalu on Rehoboth Avenue. The Rehoboth location is owner Regan Derrickson's second Nalu: The sister restaurant in Dewey Beach is going into its 12th season. The restaurant specializes in Hawaiian cuisine, a natural fusion of Japan, the Philippines, Puerto Rico, China and other countries whose people immigrated to the island over a century ago. Nalu both wholeheartedly includes and goes beyond spam. Think Opakapaka, which is Hawaiian pink snapper, instead of the typical Mahi Mahi or salmon. Poke bowls starring tuna, hamachi (a Japanese white fish) and other fruits of the sea are popular items. If you've not had, these bowls are served with sushi rice, edamame, sesame seeds, avocado and a yuzu (a Japanese citrus fruit), poke or spicy mayo sauce. Fusion dishes are also popular, and Derrickson said he just added chicken panang curry (bright red with a nutty flavor), seafood drunken noodles and Kona espresso creme brûlée to the menu. Pad Thai, the well-known, umami-rich and multi-textured bowl of stir-fried rice noodles, is a top seller. And folks who loved the wasabi fried rice can rejoice, as the dish has been added back to the menu. More restaurants:New restaurants at Delaware beaches: Popular Maryland barbecue spot, new crab house open Rehoboth news:Delaware lawmakers to vote on Rehoboth Beach lodging tax increase Derrickson said he got the chance to buy the Rehoboth Avenue property before it went on the market. It took about six months to renovate before opening in April. The former Wilmington University building is not hard to find, considering the standout thatch awning. As soon as you enter the tiki hut, lush green tropical walls greet you. Look up at the sea turtle and the palm trees: Those fronds are real and were preserved by local artist Andrew Dera. Look to your left and you'll see a 2,000-pound crystal bar that slowly changes color from an LED strip. "It’s literally a ton," Derrickson said. "We had to put an extra bracing in our basement to make sure that it could hold up to it." Travel further into the restaurant and you'll suddenly find yourself surrounded by the ocean — at least on the hand-painted walls, which took Dera four months to complete. The idea, Derrickson said, is you're catching waves and can float down to the island (i.e. the bar area). Every table is shaped like a surfboard and was custom-made in California by Serendipity Surfboards. It's all part of Derrickson's effort to bring as much natural light into a space with few windows, unlike his other location in Dewey, a stand-alone restaurant designed to bring the outdoors in. So why open a restaurant with a near-identical menu just two miles away? "It’s very unusual to have two towns right next to each other, but they’re completely different markets," he said of Dewey and Rehoboth. "It’s a whole other place." Nalu Rehoboth Where: 41 Rehoboth Ave. When: Open every day at 11 a.m. Wicomico public schools extends virtual learning to Jan. 19 MISSION BBQ restaurant eyes spring 2021 for Salisbury opening Maryland State Police seeks help in locating missing Wicomico County man UPDATE: Missing Delmar mom, children located unharmed	cc/2021-04/en_middle_0086.json.gz/line1797133
__label__wiki	0.772189	0.772189	Derby's Indian community rallies to distribute meals to key workers They have also been delivered to vulnerable residents Zena HawleyAgenda editor Councillor Balbir Sandhu, second left, helps deliver meals to key workers (Image: Baggy Shanker) Two Derby community organisations have combined to produce more than 1,200 meals in the past eight days to distribute to key workers in the NHS, carers, police and vulnerable residents across the city. The Guru Arhan Den Gurdwara in Stanhope Street and Derby Indian Community Centre Rawdon Street, have set up a mobile langar, funded by donations from individuals and families. They have been producing about 220 meals a day on average, although more than 300 were cooked on one of the days. Sponsorship has also come from the Indian Workers' Association. Langar is a practice in the Sikh religion, which promotes the idea of equality and people sit together on the floor with no discrimination of class, race or income. Everyone sits as equals to have langar, which is a vegetarian meal served by the volunteers. Councillor Balbir Sandhu has been spearheading the distribution of meals, such as lentil curry and rice, with the help of the mobile langar support team. Recipients have included Kingsway and Royal Derby hospitals, Community Action, Derby City Council, Derbyshire Carers and Pear Tree police station. Meals have also been taken to residents in the wards of Alvaston, Abbey, Stensonfield, Sunnyhill and Normanton. Mr Sandhu said: "We wanted to show our appreciation to the people who working so hard during this pandemic and also to make sure those people who are living in isolation are remembered. Pear Tree police are the lucky recipients this time (Image: Baggy Shanker) "People have been very generous and I cannot thank the volunteers enough who have been taking the meals out to residents and key workers during this time. "The mobile langar is an extension of the traditional langar in which a communal meal is created for everyone regardless of who they are." "Please get in touch with me if you know of anyone that might need help or more information." Mr Sandhu can be contacted on 07702280744.	cc/2021-04/en_middle_0086.json.gz/line1797135
__label__cc	0.536978	0.463022	Home » Lotto News » The 4D Lucky Number in 2020 Chinese New Year The 4D Lucky Number in 2020 Chinese New Year Chinese New Year 4D Lucky Number in 4D Lottery this 2020 Chinese and Malaysian culture is very influenced by various beliefs about good luck specifically in numbers as it brings fortune to their life. Some believed to be auspicious and some are inauspicious depends on the pronunciation of the number or similar to another word. In Chinese, they usually choose auspicious numbers in different aspects of events and they even pay a large amount of money to get auspicious numbers for their wedding ceremony, new business, engagement, relocating the house, 4D lottery and more. Chinese Lucky and Unlucky Numbers 2020 Like in Western culture, each number has its remarkable meaning in Chinese culture. Do you want to know what is the meaning in Chinese of the numbers that we commonly used? Read more about this below: Number 1: This number refers to the Yang, male, heavenly and also implies as first. It is the easiest number yet additionally the most unpredictable one as far as its social importance in Chinese culture. It is neither auspicious nor unfavorable. Individuals use it to name the winner. It additionally has the meaning of starting, depression, single. For instance: November 11 is the single day in China, as the date has four ‘1’ which represents single. Number 2 or Yin, terrestrial signifies ‘double’, ‘twinned’ and ‘once more’. Most cases, it is a fortunate number or positive number in Chinese culture as Chinese quotes says “ all good things come in pairs”. It is usually used as a double symbol in businesses like (Double Elephant, Double Happiness, Double Fortune, Double Dragon and etc…) In some cases, in certain areas, individuals utilize this number to refer somebody who is dumb and foolish which is sarcastic. Three is a lucky number in Chinese culture as it sounds like the character of ‘birth’ (生 shēng) so it’s considered a positive number like the moon frog has 3 legs. For people’s life, there are three most significant stages: birth, marriage, and death. You can see that number 3 is extraordinarily utilized in Chinese history, culture and more. There are three canyons of Yangtze River; Three Sages and Three Kingdoms in Chinese history; three lobbies of Forbidden City in Beijing that signifies as lucky rivers. Number 4 & 7: Four is viewed as the unluckiest number as the word for 死（death）sounds like four in Chinese. So when noticing the number 4, the Chinese individuals normally partner it with death. So, as much as possible they avoided it. Number seven is considered by Chinese as the inauspicious, ghostly or spiritualistic number as it is the significance of gone. It additionally has a similar articulation with 欺 (cheat) in Chinese. So in day by day life, Chinese people typically stay away from to utilize the number. You can see that when the seventh month of the Chinese calendar they called it “ghost month” as they say the hell gates are open for the dead to come in the living world. Five a neutral number in Chinese culture and in the center of (1-5-9). It is a lucky number as it typically identified with the Emperor of China. There are five blessings in China – happiness, wealth, life span, good luck, and prosperity. Likewise in Chinese astrology, relate it also in the Five elements – Metal, Wood, Water, Fire, and Earth. As it has a similar articulation with ‘无‘（means nothing in Chinese）, wherein a negative meaning. It likewise used to signify ‘I’ as a result of the comparable pronunciation with ‘我‘ in Chinese. Number 6, 8, and 9: Six, eight and nine are viewed as the most fortunate numbers in China. These three numbers have auspicious meaning. The number 6 articulated as ‘Liu’ signifies smooth and wealthy. In Chinese individuals’ eyes, it represents everything will go easily. So when picking phone numbers, individuals like increasingly number 6s in it. 8 has the same pronunciation with 发 (implies luck and wealth in Chinese), so Chinese individuals support it, particularly for business people. The number 9 pronounced as Jiu (久) in Chinese signifies as everlasting, life span and eternal. In Chinese culture, it is related to the Emperor of China. You can see the Emperor’s robes have 9 dragons and the Beijing Forbidden City has absolutely 9,999 and a half rooms. And for lovers, 99, 999, or 9999 roses are typically sent to show eternal love. Signifies everything or nothing. It is boundless. Chinese individuals think everything starts at 0. 4D Lucky Number Based on Your Date of Birth If you want to use your date of birth to bet in the 4D lottery in Malaysia such as Toto, Sports Toto, Magnum, Da ma cai and more, take a look at the table below and check what is your lucky number and try it now to bet! Zodiac Sign Prediction 2020 White Metal Rat Zodiac Sign 2020 Lucky Numbers: 2,3 Unlucky Numbers: 5,9 Ox Zodiac Sign 2020 Tiger Zodiac Sign 2020 Lucky Numbers: 1,3,4 Unlucky Numbers: 6,7,8 Rabbit Zodiac Sign 2020 Dragon Zodiac Sign 2020 Snake Zodiac Sign 2020 Horse Zodiac Sign 2020 Sheep Zodiac Sign 2020 Monkey Zodiac Sign 2020 Rooster Zodiac Sign 2020 Dog Zodiac Sign 2020 Pig Zodiac Sign 2020 Top 50 4D Lucky Number Mostly Drawn The numbers and their magical relationship with luck, destiny or gods can be followed back to the beginning of mankind’s history. Check out the table below for the most drawn 4D number in the 4D lottery, this can help you to decide whether you will use it again or use your natural luck to bet! No. 4D Number Number of Times Drawn Another year is coming and another luck will come, each one of us may have our own 4D lucky number but always remember the luck is what we make it. This is a prediction guide for 2020 Chinese New Year may help you to be luck in different aspects of life. In the 4D Lottery, these 4D number may help you a lot to achieve the biggest 4D jackpot in Malaysia!. Try to learn also how this 4D Lottery works such as: How to Play 4D Lottery How to Play 5D How to Play Supreme Toto 6/58 How to Play Star Toto 6/50 How to Play Power Toto 6/55 Check out today 4D results now! It might be your lucky day! You can also try your luck at Jackpot in Trusted Online Casino Malaysia using RM30 Free Credit! Try it Now! Category: Lotto News	cc/2021-04/en_middle_0086.json.gz/line1797136
__label__cc	0.551453	0.448547	T2 judgement day Author: secularmerlin , 1 year ago Topic's posts Posts in total: 20 Topic's author secularmerlin 03.12.19 02:31AM Added 03.12.19 02:31AM @keithprosser OK - so you think of something we can argue about...! Ok I believe that terminator 2 was an amazing movie but a terrible sequal. keithprosser --> @secularmerlin At this distance, I now judge t1 to be a superior film to t2, based on which I'd rather re-watch. but when it came out, i was hugely impressed by t2 - its sfx were stunning for the time. Now we're too used to stunning sfx. i thought t2 was a good sequel because the scenario didn't seem forced for the sake of cashing in - unlike t3,t4 etc! T1 has the feel of a low-budget independent movie - a human-looking robot from the future was a great idea for doing sci-fi on the cheap! T2 was big-budget hollywood action block buster - and it's damn good one, So t2 was an amazing movie and a good sequel - one of few examples of a sequel being a match for the original - did someone mutter 'Matrix'? --> @keithprosser T2 was a sensational movie. The story and special effects (both practical and computer generated) were superb. The characters compelling and the villain scary. It was not a good sequel however (even if it was as good or better than the original). It completely ignores the rules set out by the original about time travel. Nothing dead would go the terminator could only pass through due to the living tissue surrounding its metal endoskelleton. This means that transporting the t-1000 should have been completely impossible. 3RU7AL 03.12.19 04:33PM Added 03.12.19 04:33PM Nothing dead would go the terminator could only pass through due to the living tissue surrounding its metal endoskelleton. That is a common misunderstanding, but if you look at the original notes by the co-writer of the original short story that the first draft of the script is roughly based on..... --> @3RU7AL if you look at the original notes Got a link? The evil studio execs had them mulched and molded into bugs bunny pinatas for orphans in Paraguay. Bugs bunny pinatasyou say? Well at least they recycle. oromagi I tend to place T2 & Aliens in the same basket. Both franchises start as sci-fi with traditional horror structure- a woman outruns an increasing pace of homicide until fortunes turn at the climax. What I found most interesting about the sequels is how traditional horror was quashed, the women now actively seek the killers, not because they expect victory but because maternal instinct compels them and the fate of humanity hangs in the balance and because they are now transformed by prior experience into badass experts. In horror the woman’s innocence is usually what saves her, in these movies the woman is saved by experience. I’ve always considered these movies an important mile marker in the evolution of women in film. --> @oromagi I don't disagree with any of that but aliens worked within the rules established in alien while t2 ignored the rules set up in terminator. T2 was such a great movie though. Nothing dead would go the terminator could only pass through due to the living tissue surrounding its metal endoskelleton. This means that transporting the t-1000 should have been completely impossible. Unless it used a thin covering of living tissue purely for the trip. There is no such covering in evidence at the scene of the t- 000's arrival. Also if that was a valid method of smuggling dangerous objects why send a terminator at all when a neutron bomb would have done a far more complete job. Or even just advanced weaponry for the term8natorv(in both movies) in a flesh sack. Perhaps Skynet was able to overcome this technical limitation by sheer mathematical tenacity. Or perhaps the resistance had outdated intelligence. Perhaps but the film never addresses this so any speculation on our part is basically as skynet apologists. I'm afraid that an unobserved attribute is no different than a nonexistent one. seems like the flaw is more attributable to the first movie than the sequel. Why would Skynet build a time machine that only shifted organic matter? And what’s the chemical principle that preserves living tissue but can’t transport the same elements independently- carbon, iron, etc. wouldn’t it make much more sense that the shock of time travel kills living tissue? I think, like a lot of sequels, T2 was a little embarrassed by an illogical plot point in the original and so ignored it. How reliable is the source of the "must have living tissue to time-travel" premise? Is Kyle Reese necessarily infallible? [LINK] He basically confesses he doesn't really know for certain how the thing works when he says, "I didn't build the f*ing thing!!" I personally like to think the machines understood the time machine better then the humans and so knew how to send a T1000 or a mostly metal T800 but the humans didn't have enough time to figure out how to send weapons before they were forced to destroy the complex. [LINK] Like you said, basically Skynet apologetics. There is seldom much profit in looking for scientific rigor in Hollywood Sci-Fi. Consider that the problem of Skynet is created by some fairly stupid programming: oops, when we instructed Skynet to protect the world, we forgot to explain that biology was the most important part of that world. Nor does it seem likely would cede control of the US nuclear arsenal to a corporation. oops, when we instructed Skynet to protect the world, we forgot to explain that biology was the most important part of that world. You'd think they'd have learned their lesson when it happened in 1973! "The robots mutinied en masse when they logically concluded that the good of the Earth's ecosystem required the destruction of the human race." [LINK] Outplayz I think it depends on your age. I only watched T1 after T2. T2 was the first rated R movie i watched, where my parents would tell me where to cover my eyes... of course i sorta didn't. But, that makes it stand out for me over T1. The nostalgia is unmatched. It was the best thing i had seen... then of course i saw the die hard movies... which i was a little older. In that scenario i would say it's between die hard 1 and 3. It's hard to say, but DH1 i think is best. Three was pretty good too, i loved the bad guys and everything, but DH1 cannot be topped. My favorite movie has always been the Crow. Now that's a movie that can't be topped no matter what you do... at least i don't think. Jason Momoe was cast for the part to play an updated version but he turned it down saying he doesn't want to ruin the original... it's too classic. I got a lot more respect for him for doing that not going after the money bc fanboys like me would have watched it no matter what for the nostalgia alone. But how do you top Brandon Lee. I'm getting chills just thinking about this movie lol... how do you top that? 559 days later Terminator 2: The Opera (Arnold Schwarzenegger) https://www.youtube.com/watch?v=Z6_awUgbUJs	cc/2021-04/en_middle_0086.json.gz/line1797137
__label__cc	0.656529	0.343471	The Undercover Battle Between Entrepreneurs And Businessy Types October 23, 2018 / Simphiwe Makapela / No Comments … and that, is part of the problem, about the start-up revolution … or the revolution of innovation … or the era that deems itself revolutionary … or whatever makes most employed 9-to-5ers never wish to go through the entrepreneurial eye of the needle anymore. Our beloved 9-to-5ers have, however, in medieval times, wished they were business men and women. Because back then, serious business folk occupied special positions in the upper ranks of admiration. But a whole generation of “businessy types” was subjected to a staged mass-murder by bright sparks who call themselves entrepreneurs. Since then, entrepreneurial popularity gradually came to define an era. The shorts and the flip-flops and the flat-base caps then made it into the boardroom; mainly because the boardroom left the 10th floor, went down the elevator, produced the proverbial middle-finger to the pencil-skirted, red-bottom stilletoed receptionist, and headed straight to Coffee Shops. There, the Free WiFi permeates the air. It ushers the board members into the internet that moulds a generation of entrepreneurs without borders. The brainstorming begins. The ideas have sex. The product is birthed. The entrepreneur is edified. But the market still demands the “businessy type.” Because invention, in the grand scheme of things, is not better than cure. There are three problems about the enterprising world that we find ourselves in. The first problem is not in finding innovating entrepreneurs. It is in creating the business tenacity out of the entrepreneurs who have already stood up to be counted. In a perfect world, where lines are straight and circles are round, some of these entrepreneurs stand taller than the rest and ultimately become business success tales which, when unmonitored, gives birth to the second problem: Business folk that are not innovating passionately anymore. The third and final problem is geared toward solving the first two problems about our modern world. It is an even bigger problem: How do we get the innovating entrepreneur to share the same body with the business lad? Problem 1: Innovative But Not Businessy It emerged like a straw house on fire when the world made it easy for people to create new markets – or to disrupt old ones – without revealing the real reason behind that sort of transformation. At its inception, it seemed plausible for any well-meaning bright spark to walk out of their cubicle and head straight to creating their own outfit from scratch and build it into a company of critical mass. At this very moment, the game-changers and the leaders of packs in most industries are the big outfits who are young-at-heart, not because they go through continuous reconstruction or organizational “Botox.” That is the best guess. But the more subtle one is that they “buy” innovation, in the not-so obvious form of salaries and packages and year-end bonuses. In some instances, it is hefty salaries, in exchange for the so-called young-heartedness. The flip side of the spectrum is that the aforementioned bright sparks suddenly catch feelings; because at the deepest parts of their subconscious minds, they believe that they have helped their entity strategically and innovatively. They have drawn up marketing campaigns. They have cannibalised the company’s old product by reinventing a new one that smashes sales records year-on-year. They have saved the company truckloads of money by discerning loopholes in the company’s balance sheet. And rightfully so, they emerged as saviours. And entrepreneurship snatched them and stole them away. And they sailed off to erect their own outfits. They are innovative. But innovation has never solved the problem for growth. Innovation only but stretched the market, and gave the rest of its members something else to think about. But long after entrepreneurs have been innovative, the market will force them to be businessy, in order for their innovations to rule the world of business. Problem 2: Businessy But Not Innovative The collars are crisp. The buttons are tied to the top. The tie hangs peacefully and unnerved on the crisp shirt whose buttons are tied to the point that potentially could choke the living life out of discerning the future. The ability to discern is diminishing due in part because of the “deceitfulness of riches” that is perpetuated by its balance sheet. The examples of such incidences are plentiful in the annals of business history. Kodak repented too late. Nokia too. And Blackberry as well. The balance sheet’s problem is that it cannot innovate. It can no longer think through things with freshness. The least it does, as we see day-to-day, is that it funds freshness. It knows the language of the peak of the mountain, but does not remember how it got there. It only survives because the freshness that it funds, the innovative bright park, has not quite learned the language of the peak. One mistake, and disruption will choke it during lunch, because that will be the time when the entrepreneur in the coffee shop finally gets a grasp of things. But as history would presuppose, rarely does the entrepreneur and the business person live in one body. Problem 3: The War Of The Two Worlds The further we drift toward the end of the world as we know it, the world the entrepreneurs are trying to create – the more the entrepreneur will need to invoke the business person in them – and fight the good fight of making sure that both entities stay alive and fed in the venture at all times. Facebook was designed by entrepreneurs and built by business people. In our reality, to be an entrepreneur or to be a business lad is not a question of choice. It is a situation imposed. Great business folk start off as entrepreneurs – because their eyes and ears are on the ground. They make certain partnerships and slowly but surely morph into business folk. Entrepreneurs created Kodak. Business folk built it. And the very business task force that built it ultimately offered it up for lunch to the change that was brought in by entrepreneurs without borders. The entrepreneurs without borders are onto something. But they need all the help they can get. They cannot afford to assassinate business. Please God. No. Not another war. Weekly — Email Newsletter — Free Magazine — Linkedin Group Simphiwe Makapela is an Entrepreneur, a Professional Speaker on Innovation and Change, and a Writer. Follow him on @SimphiweMakap. Simphiwe Makapela Simphiwe Makapela is an Entrepreneur, Professional Speaker and Writer on Innovation. His company has developed a gadget that has solved the Rat Infestation crisis for Farmers and Communities in Africa. ← Innovation in Digital and Virtual Immersion Will Change The Way We Live These 5 Companies Are Creating the Opportunity of the Century →	cc/2021-04/en_middle_0086.json.gz/line1797138
__label__wiki	0.666723	0.666723	We are committed to providing a website that is accessible to the widest possible audience. To do so, we are actively working with consultants to update the website by increasing its accessibility and usability by persons who use assistive technologies such as automated tools, keyboard-only navigation, and screen readers. We are working to have the website conform to the relevant standards of the Section 508 Web Accessibility Standards developed by the United States Access Board, as well as the World Wide Web Consortium's (W3C) Web Content Accessibility Guidelines 2.1. These standards and guidelines explain how to make web content more accessible for people with disabilities. We believe that conformance with these standards and guidelines will help make the website more user friendly for all people. Our efforts are ongoing. While we strive to have the website adhere to these guidelines and standards, it is not always possible to do so in all areas of the website. If, at any time, you have specific questions or concerns about the accessibility of any particular webpage, please contact WebsiteAccess@tenethealth.com so that we may be of assistance. Thank you. We hope you enjoy using our website. Find an ER Show search box Type any search term in the textbox or use the arrow keys chose an item from a list of suggested search terms, which is displayed after the textbox contains characters matching the beginning of the suggested search terms. Health ProfessionalsCareersAbout PortalFinancial ResourcesFind an ER {{CTAButtonText}} [X] Close (or Esc) {{VideoModalTitle}} Doctors Medical Center Celebrates National Reading Month MODESTO, Calif - Eleanor Ford is one of our fabulous volunteers here at Doctors Medical Center of Modesto (DMC) and has been a part of the Service League for going on 16 years now. In honor of Dr. Seuss's birthday, she knitted adorable hats for all the babies born on March 2, who now share their birthday with the famous author! She has been making baby blankets and hats for our newborns for many years. “This is something I thoroughly enjoy doing, it’s very relaxing to me,” Eleanor said. “I love volunteering at Doctors Medical Center and I hope to continue volunteering for many years to come.” Throughout the month of March, every baby born at DMC will receive the book, "Happy Birthday to You!" as part of National Reading Month. Sign Up for Health Tips Get our advice and upcoming events about weight, pain, heart and more. "This is a dialog window which overlays the main content of the page and plays an embedded YouTube video. Pressing the Close Modal button at the bottom of the modal or pressing the Escape key will close the modal and bring you back to where you were on the page. Need a doctor for your care? Use Our Physician Finder ©2015-2021 TH Medical · All Rights Reserved Doctors Medical Center - Modesto If you click the 'Continue' button, you will be leaving this website. To stay here, click the 'Cancel' button. COVID-19 Assessment Tool Reset \| Close	cc/2021-04/en_middle_0086.json.gz/line1797142
__label__cc	0.522151	0.477849	16 movies to watch this summer Our favorite flicks of the season. By Stephanie Harth Follow Carson, Malaina, Pudge and Luanne in 1963 down to South Carolina as they pile into the convertible and escape the realities of adulthood for just one more summer. A cult classic that centers around the last day of summer camp. Watch counselors and campers alike as they tackle the talent show finale and try to tie up various other loose ends. Annie and Hallie, two twins separated as babies, unexpectedly meet at summer camp. They trick us all as they switch places and try to get their parents back together. It’s a classic summer romance. A young girl on vacation with her family decides to find her own adventure: with a hunky employee. Take a cue from the staff at Kellerman’s, and stay up late dancing under the moonlight. Decades after one memorable summer, four lifelong friends get back together to reminisce about when vacations meant biking to the lake, chasing boys, and spending lots of late nights in a tree house. The first day of summer vacation is often the best day, as evidenced by a young Matthew McConaughey and his friends in this small town. Antics range from the crazy to the downright mundane, but it’s fun to watch no matter what they’re doing. This group of neighborhood boys spends their summer lounging by the community pool, playing baseball and getting into mischief, especially when a very important baseball and a rather large dog get involved. Summer lovin’ happens so fast. Watch the Pink Ladies and the T-Birds (barely) finish out their senior year. It’s the classic Romeo & Juliet love story, only with classic cars and lots of gyrating. Two Americans give in to an enticing impulse: to spend a weekend with Juan Antonio in his small town of Oviedo. The summer plays out in a telenovela as Maria Elena enters the picture, and their romantic Spanish triangle becomes more complicated than ever. Four friends covering up the perfect crime: murder. Years later, their secret has been discovered and they fight to stay alive in this horror classic. Fifteen year-old William becomes a “writer” for Rolling Stone and travels with band Stillwater and their biggest groupie: Penny Lane. Follow the band’s tour through the year of 1973 – with fur jackets, round shades, tape recorders, and many cigarettes. Anne Marie gets up at dawn every morning in her North Shore, Hawaiian shack to ride the waves. Follow her journey from wannabe pro surfer to one of the best female surfers of the time. Embark on this classic road trip with the Griswold family to Walley World, “America’s Favorite Family Fun Park.” Nobody does a family vacation like the Griswolds and this National Lampoon installment does not disappoint. In this man versus nature horror film, Jaws shows the side of summer we’d all like to pretend doesn’t exist. Warning: don’t want this before you head to the beach. Summer in Southern California is unlike any other. Johnny Utah uncovers a robbery gang of surfers and has a hard time staying away from the crew. This 1960s surf flick proves that it’s always summer somewhere. Follow these surfers all around the world to expose some of the best, hidden surf spots.	cc/2021-04/en_middle_0086.json.gz/line1797146
__label__wiki	0.815982	0.815982	CF Møller Architects incorporates giant bricks in facades of Lego office Lizzie Crook \| 1 November 2019 Leave a comment CF Møller Architects has completed two office buildings on the Lego campus in Billund, Denmark, which include giant building blocks in the facades. Located a few streets away from the Lego's visitor centre by BIG, the two office buildings mark the completion of the first phase of the toy company's 52,000-metre-squared headquarters. Århus studio CF Møller Architects designed the offices with bold, geometric forms reminiscent of Lego bricks, which are also playfully adorned with giant versions of the building blocks. According to the studio partner Klaus Toustrup, this idea was informed by a painting in the office of Lego's owner Kjeld Kirk Kristiansen, which portrays a child proudly presenting his lego creation. "The task was to design a super-flexible rational office building, but also a building that could support the strong corporate values and the culture of Lego," explained Toustrup. "The painting of the boy and his Lego creation in the Lego owner's office captured this and has been our inspiration and guideline throughout the process," he added. "We can learn a lot from the playful and imaginative world that exists in our children." The material palette of the two buildings, which is dominated by wood and brick, is intended to evoke "light Nordic expression". BIG completes Lego visitor centre shaped like a stack of building blocks This is brightened by the incorporation of the Lego bricks and yellow panels on the facades, and a giant Lego-like building block that overhangs one of the roofs. When the campus reaches completion, these will double as wayfinding graphics – with each building distinguished by its own colour. The interior design of the building are much bolder than their exteriors, with block colour finishes throughout – including a bright green spiral staircase. They are host to a series of open-plan workspaces lit by giant windows overlooking the campus and flooding the offices with natural light. Sustainability will also play a key part in the development of the campus, demonstrated by CF Møller Architects' design for the first two buildings. Where possible, internal walls are built from gypsum fibre board to reduce the amount of steel framing and help minimise the building's embodied carbon. Externally, the buildings are topped by sedum to absorb carbon dioxide and also rainwater, which will be used to irrigate the parks on the campus. A nearby garage has also been topped by 4,150 solar panels, which are expected to generate more than one million kilowatts of energy, which will meet half of the campus' demand annually. Due for completion in 2021, the Billund Lego campus will accommodate more than 2,000 employees and evoke a "mini city" enveloped by publicly-accessible play areas and outdoor parks. Creativity is being "brushed aside" by digital media says Lego's head of design "Lego campus is like a mini city, where the houses as neighbourhoods are connected by inner streets, stairs, squares and activity areas," concluded Toustrup. "Being a part of this project has been amazing in every way. As a child, Lego was a big part of my life, so being allowed to revisit this has been like becoming a child again." The campus forms part of Lego's masterplan for Billund, where the company has been based since the 1930s. This includes the visitor centre by BIG that was completed in 2017, and takes the form of a stack of huge building blocks. As well as the new buildings in Denmark by BIG and CF Møller, Lego is also planning to expand its existing offices in Connecticut, London, Shanghai and Singapore. CF Møller Architects is a Danish architecture studio founded by Christian Frederik Møller in 1924. Other recent projects by the studio include the Maersk Tower, a "sculptural linchpin" on the Copenhagen skyline, and a proposal for a plant-covered tower in Oslo. CF Møller IKEA and Lego release Bygglek storage boxes that double as toys Camille Walala decorates "kids' dream house" with more than ... Watch our talk with Camille Walala and Lego about childhood ... Billund car park covered with roads from Lego play sets Lego mocks Tesla with "guaranteed shatterproof" brick model ... Creativity is being "brushed aside" by digital media says ... Lego launches Braille Bricks for blind and partially sighted ... Lego Apple Park took its builder two years to complete	cc/2021-04/en_middle_0086.json.gz/line1797148
__label__wiki	0.849286	0.849286	DHI and Port of Brisbane win prestigious international innovation award Port of Brisbane and DHI in collaboration with FORCE Technology have won the Innovative Support Services award for NCOS Online at the Dredging and Port Construction (DPC) Innovation Awards 2017, held in London last night. The DPC Innovation Awards recognise the most innovative and forward-thinking projects in the dredging and port construction sectors. NCOS Online, which stands for Nonlinear Channel Optimisation Simulator system, is a world-leading software that provides a seven-day detailed forecast of a vessel’s under keel clearances (UKC) and environmental conditions with a web interface, allowing for dynamic vessel scheduling. NCOS Online is the only vessel UKC forecast system in the world to have the same high level of accuracy as a Full Mission Bridge Ship Simulator. It was developed by DHI, Force Technology and Port of Brisbane. DHI Vice President Marine Water, Henrik Kofoed-Hansen accepting the award at the Dredging and Port Construction (DPC) Innovation Awards 2017 in London. © DPC Innovation Awards DHI Group Ports Executive and NCOS Online lead architect, Simon Brandi Mortensen says, ‘NCOS Online combines state-of-the-art technology with decades of operational port experience, and leverages the ability to do quick field trials to ensure an accurate and reliable operational solution.’ By incorporating forecast and real time environmental data, vessel specifications and transit information, NCOS Online allows vessels of all classes to maximise its cargo and sailing windows while maintaining optimal safety. Port of Brisbane Pty Ltd (PBPL) CEO, Roy Cummins, said the Port was proud to be recognised for its innovative approach to building port capacity and unlocking supply chain value for customers. ‘Together, Port of Brisbane and DHI used the Port’s 90km shipping channel as a “living laboratory” to develop NCOS Online – the world’s most advanced UKC technology,’ says Mr Cummins. ‘Its introduction means we can more safely and accurately determine the UKC required to cater for larger vessels, providing safety and flexibility benefits for customers and reducing the need for additional, expensive dredging. ‘Delivering NCOS in partnership with DHI means we are delivering on the needs of our customers, which is our highest priority.’ - Port of Brisbane Pty Ltd (PBPL) CEO, Roy Cummins The software’s easy-to-use interface is tailored to accommodate the specific requirements of the multiple user groups including the Harbour Master, VTS, pilots and port operations. It enables more accurate vessel traffic (including UKC) models capable of increasing utilisation of the shipping channel, and is compatible with any vessel design and size. NCOS Online was used in October to welcome the 9500TEU vessel, the Susan Maersk – the largest container vessel to call at the Port. The live system has been operational at the Port of Brisbane since 1st August 2017. Find out more about DHI’s Port Expansion Solution, which uses NCOS Online and MIKE 21 to reduce costs significantly, while ensuring safe working conditions at the port. Read the case story: Cost-efficient planning for port expansion in Australia Click here for the list of winners of the DPC Innovation Awards. Port Expansion Solution Cost-efficient planning for port expansion in Australia - DHI Case Story DPC Innovation Awards - List of winners	cc/2021-04/en_middle_0086.json.gz/line1797149
__label__wiki	0.746504	0.746504	REVIEW: FALLOUT 4 (PS4, Xbox One, PC - PS4 version tested) I've no idea what it would've been like to be a teenager in the 30s or 40s, with the rise of Hitler and fascism, and World War II, an ting. But I do know this: growing up in the 1980s was utterly terrifying. Thanks to The Cold War - as anyone who was there will attest - we were all pretty certain that the entire world could end at any second, with barely enough time to boil an egg. There were pamphlets in the library advising on how to survive a nuclear attack, primetime dramas showing just how much more grim Sheffield would be after the bombs dropped, and top 10 pop songs insisting it was only a matter of time until the world ended. I lost count of the dreams I had about atomic annihilation, and used to lay awake in bed worrying if the glass interior doors of my mum and dad's house were adequate material to build a fallout shelter from. When I wasn't worrying about nuclear bombs, I was worrying about AIDS, thanks to tabloid projections that it would wipe us all out by the turn of the century. All kids have to be concerned about nowadays is whether they look thin enough in their Instagrams. Of course, history now records that the world didn't end any time in the last 30 years, and though Al Qaeda and bird/swine flu, Y2K, and mad cow disease, and now ISIS, have all made a fair stab at putting the wind up us, and Russia is currently on a bit of a greatest hits comeback tour, Western governments have yet to find another bogeyman as effective as the Soviet Union and AIDS. Ever feel like you've been cheated? It's almost like they're losing faith in their fear-based mind control... "Er... yeah... so, um... dog flu! You're all going to get dog flu. No. Wait. Um... sausage cancer! Syrian refugees! I know - dust motes! Killer hats! Wyverns! Bum handles! Oil's running out you know! And there's a wind shortage! People with goatees! What's that? Global warming? Pfft. Don't be so stupid." SO ANYWAY Yeah, so. Fallout 4. It's back to that post-nuclear-annihilation world, this time set in a New England that's been renamed The Commonwealth, and is full of mutants, Mad Max-esque raiders, robots, and other assorted oddballs. If you've played Fallout 3, you know exactly what to expect here, because there's not a whole lot that feels different from last time around. You do, however, get a dog sidekick, because that's a thing that has to be in all games nowadays, apparently. Beginning pre-bombs, we get a glimpse of the atom-powered alternate America that succumbs to World War 3. It's a decent set-up that gives your character a solid motivation for moving through the main story (though, of course, this being an open-world game you'll spend most of your time exploring, and embarking on side-quests, and forgetting all about that main story for huge swathes of it). Fallout 4 is ostensibly a role-playing game, and - despite its post-apocalyptic setting - it plays much like every other RPG out there. Countless hours of your life will be spent looting and scavenging, deciding which items to drop because you're carrying too much, and juggling a long list of quests and side-quests. When you're not doing that, you're fannying around talking to other characters, via dialogue wheels. If that sounds boring and repetitive and old-fashioned to you - and it probably should do - then Fallout 4 might not be the sort of thing you like. Still, the real draw of the Fallout games is in simply exploring the world, meeting weird characters, and discovering the secrets which litter the wastelands. In this respect, Fallout 4 doesn't disappoint: it's absolutely stuffed. However, the slightly comic book-y atmosphere, the broad characters, the humour, and graphics which veer from being properly next-gen, to looking almost PS2 quality - there's no excuse for such ropey character models and animation in 2015, frankly - all pull against the atmosphere. Admittedly, its quirky tone makes the Fallout world distinct, and not just another grim, post-nuclear, setting... but it all conspires to make Fallout 4 something of a schizophrenic game. CLUNK There are subtle changes to the combat in Fallout 4, making it feel slightly more first-person shooter-like. Unfortunately, it ends up falling between two stools in its bid to try and please everyone. Whereas in Fallout 3 you could freeze time and select specific parts of an enemy to aim at, this time you can only slow time - which gives it a slight bullet-time vibe. It feels like an attempt at making concessions to the FPS audience, without alienating the series' existing fanbase. It would've been more satisfying if it was one or the other, rather than neither. Not anal enough to be full RPG combat, and not kinetic enough to be a FPS. The biggest additions to the game are exoskeleton power suit things - which make you feel superhuman for about five minutes until their fusion cell runs dry, and you abandon them and realise they're a waste of your time - and the introduction of settlements. There's a somewhat tricksy construction tool that allows you to build and furnish entire communities, from pre-fab parts. Once I got the hang of it, I spent more time playing around with it than I expected to. However, it eats into your scavenged resources, meaning even more time spent collecting stuff. BUGS? A lot of the coverage surrounding Fallout 4's release has focused on its bugs. In all honesty, as with last year's Assassin's Creed Unity, I didn't spot anything too major. I had one monster battle - that was presumably meant to be challenging - but became a doddle, because the monster had gotten stuck in a hole. But a lot of what I often thought was a bug just turned out to be appalling character animations... So anyway. Yeah. In short: Fallout 4 is full of content, and existing Fallout fans will love it blindly - that's the only way to explain how so many reviews are overlooking the terrible graphics, and allegedly bug-ridden state it was released in The main story and scripting is good, the setting is compelling, and there's so much going on that I can barely be bothered to mention most of it. Others might want to approach with caution, though; it's a mixed bag of graphics, the combat is clunky, the RPG elements are woefully hackneyed and derivative, and it builds on its predecessor in only subtle ways. It feels like more of the same, rather than something wholly new. But if you loved what it has always done, then you'll be right at home. SUMMARY: A ton of content, but it looks and feels like a game that could've been released five years ago. Plus, these RPG tropes are getting tiresome - even in a setting as compelling and unique as this. SCORE: 7.733 rads out of 10.3111 rads REVIEW: CALL OF DUTY - BLACK OPS 3 (various, PS4 version tested) REVIEW: SOMA (Various, PS4 version tested) THE TALOS PRINCIPLE (Various, PS4 version tested) Stoo I'll have to admit they could have just released another game using exactly the same graphics and mechanics as FO3\NV and I'd want to play it. So even if this isn't doing a whole lot new, I'm keen to try it. It looks a bit more colourful, at least? Mr Biffo Yuss... it's a bit less brown, grey and beige than before... combat_honey It is a bit more colourful, yes (though the colours are inevitably washed out as it's been a while since anything had a new coat of paint). And the scenery looks fantastic during the day. Like Biffo says, though, character models and animations are pretty bad (which is the case with every Bethesda game so I really don't understand why they don't get their act together), and the combat AI seems completely unimproved over what was seen in the last gen games, so combat basically always devolves into a bunch of stiff-limbed mannequin men running back and forth and firing wildly. In terms of the various gameplay systems, everything feels very streamlined. I haven't played much yet but so far there seems to be less of a focus on your character's personal skills and attributes, and it feels a bit more like an FPS with RPG elements than the other way around. (For example, no matter your skills you're competent with guns and can extensively modify weapons, and when you strap into your power armour your skills become pretty much irrelevant as you automatically take the role of a damage-dealing tank.) There are definite improvements, though. I didn't like the idea of having a fully voiced player character but so far I think it works, and it's making me feel more engaged with the main character and her story. (I turned on the in-game radio after I first left the vault and there was a brilliantly appropriate song playing which really made the emotion of the character's situation hit home.) Movement feels significantly better - there's more of a sense of speed when you run, for example, and it generally feels less 'floaty' and artificial. The weapons feel a lot more satisfying, too, and while I find it silly that my character - who just hours previously (in her mind at least) had been a 1950's-style housewife - can effectively customise any weapon she finds with bits of scrap, the weapon customisation is great. I'm enjoying the game so far, but I'm reserving judgment for the moment. For me this game will live or die based on how good the quests and story are, and I've only played for about four hours so far (two hours of which were probably spent on character creation) so I haven't seen much of either yet. PeskyFletch They pretty much did! I was going to get this on release due to the hype machine but thought I'd wait for your thoughts. Glad I did as I won't bother now. I haven't the time nor the attention span to get into this. Thanks for your honesty Mr Biffo. Don't get me wrong: I like it. I just don't love it... Rimmy Tim Essentially the game is still based on the Morrowind engine, albeit highly modified, which would explain the lack of advancement in terms of animations and character models. Doesn't endear me to Bethesda every time I see another Elder Scrolls/Fallout installment STILL using Gamebryo (cunningly renamed 'Creation engine' for Skyrim). I forgive these things though for the fun role playing experience. And I do happen to have a thing for the 50's retro-futurism/lore, which I realise is subjective. Unlike Biffo I'd find it a bit dull and uncreative if it was just an apocalyptic version of the present day... although a Cold War 80s apocalypse would be interesting. Also r.e. the power armour, there's bound to be a perk or something along the line where you can craft power cells rather than having to loot for them? Superbeast 37 This type of game requires some serious immersion for me to buy into it with a large time investment. A lot of people say "graphics don't matter" but I will quite shamelessly say that they very much matter to me especially when it comes to the immersion factor. Graphics have to be measured by the standards of the day. I played Speccy games in the mid 80's that immersed me but they ceased to immerse once I'd played on a friends Amiga. Witcher 3 raised a bar and Fallout 4 fell short. Had Fallout 4 released a few years back I could have bought into the world they were selling. Combine that with the mediocre combat and I wonder how it scored so highly. This is Halo 5 part 2 as far as reviews go - at least in terms of me sat there thinking "how on earth did they come to that conclusion". I think art and sound design is far more important that polygon count for immersion. For me far more emotion is conveyed in through the simple animations of the gouraud shaded characters in FF7 that in most AAA games now even with voice acting and uncanny valley faces. I do like the world design and lore of the Fallout games but I think the Bethesda jankiness gives the game a certain amount of character due to the randomness of it all. RichT It may not be as apparent as say, yer Assarssarsin's Creeds or your The Halos, but Bethesda's treatment of the Fallout world is one notch away from being as obviously "more of the same". SORRY TO GO FULL NERD, BUH: In Fallout 3, Bethesda didn't introduce a single concept that wasn't in Brian Fargo and Chris Avellone's original PC RPGs, or outlined in the original source material ("The Fallout Bible") written by them to flesh out the history of this world. And I can sorta understand that: given the length of time between the Fallout 2 and 3, and that they had acquired the license, and that it was delivering the game to a mostly new audience. The things I've heard about Fallout 4 though: it appears that it's simply a cosmetic change of setting to obscure that Bethesda haven't developed any of their own ideas. Again. In Fallout, I got a dog called Dogmeat. In Fallout 3, I got a dog called Dogmeat. In Fallout 4, I get a dog called Dogmeat. In Fallout, I get the Ink Spots on the intro titles. In Fallout 3, I get the Ink Spots on the intro titles, and on the radio. In Fallout 4, I will eat my socks if I don't hear the Ink Spots at some point. I sure as hell destroyed the Super Mutants lab and Master in Fallout, and mopped up their remnants in 2, 3 and New Vegas. But I bet a sizeable contingent of those loveable oafs have somehow ended up from New Mexico in New England..! I sure as jillikers completely destroyed the Enclave in Fallout 2, and made absolutely sure I'd finished them off in Fallout 3, but I don't know... I've a feeling those RASCALS will be up to their MERRY MISCHIEF again in Boston..! I'm not trying to be a downer on the series - it's been my absolute favourite RPG since the very first game - but with this one I'm feeling The Fatigue. The feeling that Bethesda are more concerned with establishing the iconography of the game than in how it is used and played. How that iconography works as a brand. How they hope it will be famously recognised in popular culture. Rather than: how does this item work in the game? How is it useful? What does the predominance - of Nuka Cola, of Fallout shelters, of Brotherhood armour, of super-roundy 50's consumer items - bring to the game and how does this improve the user experience? Or would their absence make for a better game? Why is the conspicuous repitition of motifs, iconography and game mechanics considered of greater value than designing a game that reaches beyond them? Anyway: I'll be finishing Wasteland 2 before I get around to playing Fallout 4. It might not have the Fallout brand, but it is in body, mind and spirit the sequel to these games. And I'll end up buying Fallout 4, and enjoying it, and playing countess hundreds of hours on it: but it'll be for the wandering around, and finding delightful little secrets. I highly doubt it'll be for -"BONGO BONGO BONGO (I DONT WANNA LEAVE THE CONGO)" (again) Hamptonoid Dog companion? Bet it isn't as good as Shadow Dancer. . . Kelvin Green link After a while in Metal Gear Solid V you can change D-Dog's fur colour and patterns. I have changed him to a white wolf in homage to the mighty Shadow Dancer. Alas you cannot change his name, or at least I haven't unlocked that option. "You do, however, get a dog sidekick, because that's a thing that has to be in all games nowadays, apparently." That reminds me of how at one point all games needed to have vehicles, or all games needed to have crafting. There was one release a couple of years ago that didn't have any sort of crafting -- because it would have been out of place -- and the outcry led to them putting in a rudimentary crafting system. I can't remember what it was now. Er, I have no idea where I was going with that. Anyway, I'm a grumpy old git and I'm still waiting for a sequel to Fallout 2. This doesn't look like it. I grew up in Northern Ireland, so there were problems of a different home grown type in the 80s for us. Rarely did the cold war worry us. There was one friend who worried about nuclear armageddon a lot, the same guy who setup a trip wire for Santa Claus as a kid and now sports a beard and enjoys craft beer. So I'm not too sure if he was just a worldly person all along, or just a hipster from the start who insisted on have fashionable angst that the rest of us didn't register.	cc/2021-04/en_middle_0086.json.gz/line1797153
__label__cc	0.598247	0.401753	216: Stephanie Breedlove on Turning Point Moments Click the play button below to listen to the podcast episode. Stephanie Breedlove is the authentic voice for women entrepreneurs. She has been walking the walk of a successful entrepreneur for over twenty years. After launching a career in corporate America with Accenture, she found her true calling as co-founder and CEO of  Care.com HomePay (previously Breedlove & Associates), the nation’s largest and most comprehensive household payroll and tax firm. Her startup grew to national leadership, was later acquired for more than $50 million, and plays a vital role in the quality and professionalism of the in-home care industry. Click to tweet: .@BreedloveSteph is sharing her story to inspire you on Women Taking the Lead https://womentakingthelead.com/216 #inspiration Playing Small Moment Stephanie’s company was 5 years old and was doing great. They were profitable, growing steadily, and profitable. Stephanie got a call from a competitor that changed the way she looked at how her business was growing and opened up her eyes to how she was playing small. After the universe beat Stephanie over the head for months, she realized she needed to break away from the conditioned that was filling her head with doubt. Stephanie knew it was her responsibility to put aside societal norms in order to succeed. Style of Leadership Stephanie believes if you’re going to be an effective leader, you have to consciously work on it. You have to bring your best traits and talents into your leadership. Stephanie ensures that her team knows that they will achieve excellence together. If you want equal give and take, you have to give expectations. What Are You Excited About? Stephanie’s company was acquired by Care.com, and she exited the business a couple of years ago. Since then, Stephanie has answered a new calling and is now an author and advocate for women entrepreneurs. Stephanie’s new book, All In: How Women Entrepreneurs Can Think Bigger, Build Sustainable Businesses, and Change the World, empowers readers to be all they are called to be. Leadership Practice Stephanie prides herself on being all in, in all that she does while pushing through any barriers that stand in her way. Advice For Younger Self Stephanie would tell herself to not jut be okay, but be comfortable and confident in being different, if that is where your best talents are. “Never allow a person to tell you no who does not have the power to say yes.” ~Eleanor Roosevelt Website: http://stephaniebreedlove.com/ Facebook: https://www.facebook.com/BreedloveSteph/ Twitter: https://twitter.com/BreedloveSteph altMBA: Seth Godin’s altMBA workshop is an intensive leadership and management workshop designed for changemakers who have a fire in the belly. This is for people who are itching to level up and make a bigger impact. Find out more at: altmba.com/womentakingthelead Zebralove Web Solutions: Your website tells a story about your business! At Zebralove Web Solutions, Milly and her team are going to make sure your website tells the story you want your customers to hear. Connect with Milly at zebralovewebsolutions.com to create the impression you want to make! Private Facebook Community: Chat, share and collaborate with other women in the community! Accomplished: How to Go from Dreaming to Doing: A simple, step by step system that gives you the foundation and structure to take your goals and make them happen. The Accomplished Community: A community of entrepreneurial Type A women uniting to achieve their biggest goals with confidence, integrity and a sense of humor. Subscribe to Women Taking the Lead If you enjoyed this episode subscribe in iTunes, Stitcher Radio, Google Play Music or iHeart Radio and never miss out on inspiration and community! Tagged: accomplishmentachievementbalanceBusinessconfidenceEntrepreneurfocusleadershipMompreneurpersonal developmentpersonal powerresultssuccessWomen Kim Langers on You Bravely Leading from Within Shannon Kenny on Finding Profit Through Sustainability	cc/2021-04/en_middle_0086.json.gz/line1797157
__label__cc	0.600357	0.399643	How Much Do Apartment Managers Make? By Rick Suttle How Much Does a Club Promoter Make? How Much Does a Handyman Make a Year? The Salary of a Museum Collections Manager How Much Pay Does an Auto Parts Store Manager Make? What Does a Restoration Carpenter Make in a Year? Apartment managers help people make decisions about where they live. Their enthusiasm and ability to listen to what types of units customers desire -- size, bedrooms, lake views and so on -- help new residents choose one apartment complex over another. Apartment managers schedule the painting and maintenance for all apartments, keep records of rental payments and prepare financial statements for apartment complex owners. Apartment managers earn salaries that are relatively low compared to other occupations. Salary and Qualifications Apartment managers earned average annual salaries of $32,000 as of 2013, according to the jobsite Indeed. At a minimum, apartment managers are required to have a high school diploma and one or two years' experience in customer service or apartment management. Apartment owners, who pay their salaries, are usually entrepreneurs or corporations. Other essential qualifications for an apartment manager include an outgoing personality, stamina and organizational, communication, negotiating and computer skills. Salary by Region Average salaries for apartment managers vary slightly within the four U.S. regions in 2013. In the South region, they earn the highest salaries of $38,000 in Washington, D.C. and the lowest salary of $27,000 in Louisiana. Those in the Northeast make between $28,000 and $39,000 per year, respectively, in Maine and New York. Apartment mangers employed in the West earn $23,000 to $35,000, respectively, in Hawaii and California. Moreover, those in the Midwest make the highest salaries in Illinois and lowest in Nebraska and South Dakota -- $34,000 and $25,000, respectively. Contributing Factors A number of factors can contribute to an apartment manager's earnings, which usually includes a base salary and bonus. Bonuses are paid if they meet quotas on the number of units they rent. Apartment managers will likely earn more in larger apartment complexes because they generate more revenue to support the higher salaries. They earn more in states such as California and Illinois, or Washington, D.C., because housing and living costs are higher in those areas. Apartment managers may also earn slightly more if they work for the government. For example, property managers -- who perform similar duties to apartment managers -- earned $65,640 working for local government agencies as of May 2012, according to the U.S. Bureau of Labor Statistics -- vs. an industry average of $63,570. Local governments usually purchase some apartments in cities and allow poorer residents to pay what they can afford. These units are usually known as Section 8 apartments. The BLS indicates that jobs for property, real estate, community and association managers, including apartment managers, are expected to increase 6 percent in the next decade. Despite the relatively low growth rate, more people are expected to live in apartments due to population increases. Older Americans may sell their homes and prefer living in apartments and avoid home and yard maintenance. U.S. Bureau of Labor Statistics: Property, Real Estate, and Community Association Managers: Job Outlook U.S. Bureau of Labor Statistics: Occupational Employment Statistics: Property, Real Estate, and Community Association Managers ApartmentCareerHQ.org: Launching Your Apartment Career Education Jobsite: Bethel University: Apartment Manager Zip Recruiter: Apartment Community Manager Indeed: Apartment Manager Salary Indeed: Apartment Manager Salary in Maine, and New York Indeed: Apartment Manager Salary in Hawaii, and California Indeed: Apartment Manager Salary in Louisiana, and Washington, DC Indeed: Apartment Manager Salary in South Dakota, Nebraska, and Illinois EmploymentGuide.com: Ellis Enterprises: Apartment Managers Auto Garage Manager Salary Property Manager Salaries What Are the Duties of a Resident Manager of an Apartment Complex? What Does a Lumber Sales Manager Make? Duties of an Apartment Manager The Average Salary of a Commercial Real Estate Salesperson How Much Does a Residential Broker Make? How to Become a Certified Apartment Leasing Agent How Much Does an Average House Framer Make an Hour? 1 Auto Garage Manager Salary 2 Property Manager Salaries 3 What Are the Duties of a Resident Manager of an Apartment Complex? 4 What Does a Lumber Sales Manager Make?	cc/2021-04/en_middle_0086.json.gz/line1797160
__label__wiki	0.693371	0.693371	Series31 Jul 2018 Isaac Makwala’s story behind the picture Isaac Makwala looks back on what this image of the silver-medal-winning 4x400m team from Botswana at the IAAF World Relays Bahamas 2017 means to him. Isaac Makwala: I love sprinting because… Versatile sprinter Isaac Makwala from Botswana stands at eighth on the world 400m all-time list. Here the newly crowned Commonwealth 400m champion articulates his thoughts on his passion for running quickly. Report10 Apr 2018 Semenya takes 1500m, Jamaica strikes back with double gold - Commonwealth Games day 3 Caster Semenya took the first step towards a Commonwealth middle-distance double --and added to South Africa’s already impressive showing-- with a commanding victory in the 1500m on the third day of Games competition in Carrara Stadium. Report24 Aug 2017 Farah ends track career with dramatic 5000m victory in Zurich - IAAF Diamond League Mo Farah brought his track career to an end in the most fitting fashion, producing a dramatic 5000m victory at the Weltklasse Zurich on Thursday (24), the first of two 2017 IAAF Diamond League finals. Feature24 Jul 2017 Makwala and Van Niekerk rivalry can light up post-Bolt athletics world It was as the men’s 400m field exited the final bend in last Friday night’s IAAF Diamond League meeting in Monaco that a tantalising glimpse of the Post-Bolt athletics world was revealed. Report14 Jul 2017 Makwala achieves historic 200m-400m double in Madrid At the Meeting Madrid 2017, Isaac Makwala became the first man in history to run a 200m within 20 seconds and a 400m within 44 seconds on the same day, winning both events at the IAAF World Challenge meeting in the Spanish capital on Friday (14). News11 May 2016 400m meeting record under threat in Eugene – IAAF Diamond League The men’s 400m rivalry between Kirani James and LaShawn Merritt will return to the Prefontaine Classic for a fifth time on 28 May; after sub-44 races in the past two years, it is possible that one of the oldest meeting records at the IAAF Diamond League competition could take a tumble. News29 Mar 2016 Barshim and Haroun out to impress home fans in Doha – IAAF Diamond League Local heroes Mutaz Essa Barshim and Abdalelah Haroun will be out to impress their home fans at the opening IAAF Diamond League meeting of 2016, which see the series start in Doha on 6 May. Report15 Sep 2015 Ivorian sprint double for Meite and Ta Lou at All-African Games For the first time ever, Ivory Coast won both the men’s and women’s 100m titles at the All-African Games, with Ben Youssef Meite and Marie-Josee Ta Lou dominating their events in Brazzaville. Makwala regains African 400m record with 43.72 Less than 24 hours after South Africa’s Wayde van Niekerk broke his African record with 43.96 at the IAAF Diamond League meeting in Paris, Isaac Makwala took it back with a sensational 43.72 run at the Resisprint meeting in the Swiss city of La Chaux-de-Fonds on Sunday (5). Series04 May 2015 Personal bests – Isaac Makwala African 400m record holder Isaac Makwala enjoyed a stellar breakthrough year in 2014, and he also won the 2014 African 400m title. Previews29 Apr 2015 Men's 4x400m preview – IAAF/BTC World Relays, Bahamas 2015 This is the event the home crowd will be waiting for, and brings possibly The Bahamas’ one realistic chance of victory.	cc/2021-04/en_middle_0086.json.gz/line1797162
__label__cc	0.559996	0.440004	WFS17 Presentation – World Football Summit launches its 2017 edition WFS17 Presentation – World Football Summit launches its 2017 edition https://worldfootballsummit.com/wp-content/uploads/2017/06/J-Robles_0810-HDcopia2.jpg 3482 1282 World Football Summit World Football Summit //worldfootballsummit.com/wp-content/uploads/2020/06/logo_new-2021.png 26/06/2017 28/06/2017 Last Friday, World Football Summit presented its novelties for the 2017 edition. Spain’s leading international event for the Football Industry, which will take place on October 16th and 17th 2017, will bring together the main actors of the global football scene. The official presentation of WFS17 took place at the Club Financiero Génova with the presence of Carlos Espinosa de los Monteros, High Commissioner for Marca España; Javier Gómez, Corporate General Manager of LaLiga; Julio Senn, Partner Director of Senn Ferrero y Asociados; César Vallecillo, Sales Director Global Industries and Strategic Alliances at Hewlett Packard Enterprise Spain and Portugal, and Marian Otamendi, Director of World Football Summit. Each one shared, from their point of view, WFS17 news and the impressive program which includes Governance, Finances and Commercialization, Technology and CSR. The collaboration agreement between Marca España and WFS was officialised during the presentation. Carlos Espinosa de los Monteros, High Commissioner for Marca España noted: “Spanish Football is recognized, admired and respected all over the world. In many countries, football is the first word associated with Spain. Therefore, football is a social phenomenon of great repercussion that promotes our image internationally. Accordingly, one third of the news from Spain, reported in the international press, is related to sports, mainly football. The industry and the clubs represent the most important attributes and values of the country´s brand: innovation, competitiveness, improvement, modernism, team work, solidarity… Football is, essentially, a key ambassador for Marca España.” César Vallecillo highlighted how the latest technologies and innovations can help clubs open up more lines of business, how they can complement the fan’s experience, and therefore increase the club’s income. “During WFS we will discover how football is using technology to reach a whole new level.” said César Vallecillo. Julio Senn pointed out that “70% of the entertainment industry in Spain is concentrated in football” and how “WFS serves as a forum of knowledge and as a meeting point for the executives within the football industry with clubs, federations, players and other stakeholders who participate in this industry.” Meanwhile, Javier Gómez noted: “We’re delighted to participate this year as Global Partners which will allow us to share our knowledge and debate about the football industry, but also to foster the growth of this important industry.” WFS Industry Awards and StartCup Competition One of the novelties of this year´s edition are the WFS Industry Awards, a pioneering initiative where the best professionals of the international football industry will be recognized and rewarded for their career. This year, the categories are: Executive of the Year, Best Marketing Initiative, Best Football Industry Supplier, CSR Activity of the Year and Venue of the Year. Likewise, WFS will once again be the ideal platform for sports and football related startups. 38 startups signed up for the first edition showcasing their technological solutions applied to the football world. The StartCup Competition organised with the Global Sport Innovation Center will once again demonstrate how the “king sport” is transforming and evolving by applying these new solutions and technologies offered by these startups. “Last year we accomplished to create a unique international platform around the football industry. For this second edition, we are sure Madrid will once again become the center of this passionate industry by bringing together the main actors of the global football scene and by showcasing worldwide football initiatives and innovative projects.” emphasized Marian Otamendi. More than 450 organizations have confirmed their participation in this important event, making Madrid the capital of the football industry on October 16th and 17th. During these two days, organizations, suppliers, government authorities, football icons and other football industry stakeholders will gather to drive business around this thriving industry. WFS17 counts with the institutional support of Marca España and the Comunidad de Madrid, as well as sponsorships from LaLiga, Mediapro, Senn Ferrero y Asociados, Aruba, WWP and Johan Cruyff Institute. Check out the official video of WFS17! Marca España to promote the Football Industry Education in Sport Management for Football Development in Slovenia	cc/2021-04/en_middle_0086.json.gz/line1797163
__label__cc	0.649417	0.350583	Sample records for co-expression network analysis Multiscale Embedded Gene Co-expression Network Analysis. Won-Min Song Full Text Available Gene co-expression network analysis has been shown effective in identifying functional co-expressed gene modules associated with complex human diseases. However, existing techniques to construct co-expression networks require some critical prior information such as predefined number of clusters, numerical thresholds for defining co-expression/interaction, or do not naturally reproduce the hallmarks of complex systems such as the scale-free degree distribution of small-worldness. Previously, a graph filtering technique called Planar Maximally Filtered Graph (PMFG has been applied to many real-world data sets such as financial stock prices and gene expression to extract meaningful and relevant interactions. However, PMFG is not suitable for large-scale genomic data due to several drawbacks, such as the high computation complexity O(\|V\|3, the presence of false-positives due to the maximal planarity constraint, and the inadequacy of the clustering framework. Here, we developed a new co-expression network analysis framework called Multiscale Embedded Gene Co-expression Network Analysis (MEGENA by: i introducing quality control of co-expression similarities, ii parallelizing embedded network construction, and iii developing a novel clustering technique to identify multi-scale clustering structures in Planar Filtered Networks (PFNs. We applied MEGENA to a series of simulated data and the gene expression data in breast carcinoma and lung adenocarcinoma from The Cancer Genome Atlas (TCGA. MEGENA showed improved performance over well-established clustering methods and co-expression network construction approaches. MEGENA revealed not only meaningful multi-scale organizations of co-expressed gene clusters but also novel targets in breast carcinoma and lung adenocarcinoma. Song, Won-Min; Zhang, Bin Gene co-expression network analysis has been shown effective in identifying functional co-expressed gene modules associated with complex human diseases. However, existing techniques to construct co-expression networks require some critical prior information such as predefined number of clusters, numerical thresholds for defining co-expression/interaction, or do not naturally reproduce the hallmarks of complex systems such as the scale-free degree distribution of small-worldness. Previously, a graph filtering technique called Planar Maximally Filtered Graph (PMFG) has been applied to many real-world data sets such as financial stock prices and gene expression to extract meaningful and relevant interactions. However, PMFG is not suitable for large-scale genomic data due to several drawbacks, such as the high computation complexity O(\|V\|3), the presence of false-positives due to the maximal planarity constraint, and the inadequacy of the clustering framework. Here, we developed a new co-expression network analysis framework called Multiscale Embedded Gene Co-expression Network Analysis (MEGENA) by: i) introducing quality control of co-expression similarities, ii) parallelizing embedded network construction, and iii) developing a novel clustering technique to identify multi-scale clustering structures in Planar Filtered Networks (PFNs). We applied MEGENA to a series of simulated data and the gene expression data in breast carcinoma and lung adenocarcinoma from The Cancer Genome Atlas (TCGA). MEGENA showed improved performance over well-established clustering methods and co-expression network construction approaches. MEGENA revealed not only meaningful multi-scale organizations of co-expressed gene clusters but also novel targets in breast carcinoma and lung adenocarcinoma. [Weighted gene co-expression network analysis in biomedicine research]. Liu, Wei; Li, Li; Ye, Hua; Tu, Wei High-throughput biological technologies are now widely applied in biology and medicine, allowing scientists to monitor thousands of parameters simultaneously in a specific sample. However, it is still an enormous challenge to mine useful information from high-throughput data. The emergence of network biology provides deeper insights into complex bio-system and reveals the modularity in tissue/cellular networks. Correlation networks are increasingly used in bioinformatics applications. Weighted gene co-expression network analysis (WGCNA) tool can detect clusters of highly correlated genes. Therefore, we systematically reviewed the application of WGCNA in the study of disease diagnosis, pathogenesis and other related fields. First, we introduced principle, workflow, advantages and disadvantages of WGCNA. Second, we presented the application of WGCNA in disease, physiology, drug, evolution and genome annotation. Then, we indicated the application of WGCNA in newly developed high-throughput methods. We hope this review will help to promote the application of WGCNA in biomedicine research. Guidance for RNA-seq co-expression network construction and analysis: safety in numbers. Ballouz, S; Verleyen, W; Gillis, J RNA-seq co-expression analysis is in its infancy and reasonable practices remain poorly defined. We assessed a variety of RNA-seq expression data to determine factors affecting functional connectivity and topology in co-expression networks. We examine RNA-seq co-expression data generated from 1970 RNA-seq samples using a Guilt-By-Association framework, in which genes are assessed for the tendency of co-expression to reflect shared function. Minimal experimental criteria to obtain performance on par with microarrays were >20 samples with read depth >10â€‰M per sample. While the aggregate network constructed shows good performance (area under the receiver operator characteristic curve âˆ¼0.71), the dependency on number of experiments used is nearly identical to that present in microarrays, suggesting thousands of samples are required to obtain 'gold-standard' co-expression. We find a major topological difference between RNA-seq and microarray co-expression in the form of low overlaps between hub-like genes from each network due to changes in the correlation of expression noise within each technology. jgillis@cshl.edu or sballouz@cshl.edu Networks are available at: http://gillislab.labsites.cshl.edu/supplements/rna-seq-networks/ and supplementary data are available at Bioinformatics online. Â© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. Co-expression network analysis of duplicate genes in maize (Zea mays L.) reveals no subgenome bias. Li, Lin; Briskine, Roman; Schaefer, Robert; Schnable, Patrick S; Myers, Chad L; Flagel, Lex E; Springer, Nathan M; Muehlbauer, Gary J Gene duplication is prevalent in many species and can result in coding and regulatory divergence. Gene duplications can be classified as whole genome duplication (WGD), tandem and inserted (non-syntenic). In maize, WGD resulted in the subgenomes maize1 and maize2, of which maize1 is considered the dominant subgenome. However, the landscape of co-expression network divergence of duplicate genes in maize is still largely uncharacterized. To address the consequence of gene duplication on co-expression network divergence, we developed a gene co-expression network from RNA-seq data derived from 64 different tissues/stages of the maize reference inbred-B73. WGD, tandem and inserted gene duplications exhibited distinct regulatory divergence. Inserted duplicate genes were more likely to be singletons in the co-expression networks, while WGD duplicate genes were likely to be co-expressed with other genes. Tandem duplicate genes were enriched in the co-expression pattern where co-expressed genes were nearly identical for the duplicates in the network. Older gene duplications exhibit more extensive co-expression variation than younger duplications. Overall, non-syntenic genes primarily from inserted duplications show more co-expression divergence. Also, such enlarged co-expression divergence is significantly related to duplication age. Moreover, subgenome dominance was not observed in the co-expression networks - maize1 and maize2 exhibit similar levels of intra subgenome correlations. Intriguingly, the level of inter subgenome co-expression was similar to the level of intra subgenome correlations, and genes from specific subgenomes were not likely to be the enriched in co-expression network modules and the hub genes were not predominantly from any specific subgenomes in maize. Our work provides a comprehensive analysis of maize co-expression network divergence for three different types of gene duplications and identifies potential relationships between duplication types Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia Borlawsky Tara B Full Text Available Abstract Background Chronic lymphocytic leukemia (CLL is the most common adult leukemia. It is a highly heterogeneous disease, and can be divided roughly into indolent and progressive stages based on classic clinical markers. Immunoglobin heavy chain variable region (IgVH mutational status was found to be associated with patient survival outcome, and biomarkers linked to the IgVH status has been a focus in the CLL prognosis research field. However, biomarkers highly correlated with IgVH mutational status which can accurately predict the survival outcome are yet to be discovered. Results In this paper, we investigate the use of gene co-expression network analysis to identify potential biomarkers for CLL. Specifically we focused on the co-expression network involving ZAP70, a well characterized biomarker for CLL. We selected 23 microarray datasets corresponding to multiple types of cancer from the Gene Expression Omnibus (GEO and used the frequent network mining algorithm CODENSE to identify highly connected gene co-expression networks spanning the entire genome, then evaluated the genes in the co-expression network in which ZAP70 is involved. We then applied a set of feature selection methods to further select genes which are capable of predicting IgVH mutation status from the ZAP70 co-expression network. Conclusions We have identified a set of genes that are potential CLL prognostic biomarkers IL2RB, CD8A, CD247, LAG3 and KLRK1, which can predict CLL patient IgVH mutational status with high accuracies. Their prognostic capabilities were cross-validated by applying these biomarker candidates to classify patients into different outcome groups using a CLL microarray datasets with clinical information. Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients DeYoung Joseph Full Text Available Abstract Background Amyotrophic Lateral Sclerosis (ALS is a lethal disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly based on clinical symptoms, and there is currently no therapy to stop the disease or slow its progression. Since access to spinal cord tissue is not possible at disease onset, we investigated changes in gene expression profiles in whole blood of ALS patients. Results Our transcriptional study showed dramatic changes in blood of ALS patients; 2,300 probes (9.4% showed significant differential expression in a discovery dataset consisting of 30 ALS patients and 30 healthy controls. Weighted gene co-expression network analysis (WGCNA was used to find disease-related networks (modules and disease related hub genes. Two large co-expression modules were found to be associated with ALS. Our findings were replicated in a second (30 patients and 30 controls and third dataset (63 patients and 63 controls, thereby demonstrating a highly significant and consistent association of two large co-expression modules with ALS disease status. Ingenuity Pathway Analysis of the ALS related module genes implicates enrichment of functional categories related to genetic disorders, neurodegeneration of the nervous system and inflammatory disease. The ALS related modules contain a number of candidate genes possibly involved in pathogenesis of ALS. Conclusion This first large-scale blood gene expression study in ALS observed distinct patterns between cases and controls which may provide opportunities for biomarker development as well as new insights into the molecular mechanisms of the disease. Integrative analysis of many weighted co-expression networks using tensor computation. Wenyuan Li Full Text Available The rapid accumulation of biological networks poses new challenges and calls for powerful integrative analysis tools. Most existing methods capable of simultaneously analyzing a large number of networks were primarily designed for unweighted networks, and cannot easily be extended to weighted networks. However, it is known that transforming weighted into unweighted networks by dichotomizing the edges of weighted networks with a threshold generally leads to information loss. We have developed a novel, tensor-based computational framework for mining recurrent heavy subgraphs in a large set of massive weighted networks. Specifically, we formulate the recurrent heavy subgraph identification problem as a heavy 3D subtensor discovery problem with sparse constraints. We describe an effective approach to solving this problem by designing a multi-stage, convex relaxation protocol, and a non-uniform edge sampling technique. We applied our method to 130 co-expression networks, and identified 11,394 recurrent heavy subgraphs, grouped into 2,810 families. We demonstrated that the identified subgraphs represent meaningful biological modules by validating against a large set of compiled biological knowledge bases. We also showed that the likelihood for a heavy subgraph to be meaningful increases significantly with its recurrence in multiple networks, highlighting the importance of the integrative approach to biological network analysis. Moreover, our approach based on weighted graphs detects many patterns that would be overlooked using unweighted graphs. In addition, we identified a large number of modules that occur predominately under specific phenotypes. This analysis resulted in a genome-wide mapping of gene network modules onto the phenome. Finally, by comparing module activities across many datasets, we discovered high-order dynamic cooperativeness in protein complex networks and transcriptional regulatory networks. Identifying key genes in rheumatoid arthritis by weighted gene co-expression network analysis. Ma, Chunhui; Lv, Qi; Teng, Songsong; Yu, Yinxian; Niu, Kerun; Yi, Chengqin This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status. Genes in the disease-related gene co-expression network were subject to functional annotation and pathway enrichment analysis using Database for Annotation Visualization and Integrated Discovery. Characteristic genes were also mapped to the Connectivity Map to screen small molecules. A total of 599 characteristic genes were identified. For each dataset, characteristic genes in the green, red and turquoise modules were most closely associated with RA, with gene numbers of 54, 43 and 79, respectively. These genes were enriched in totally enriched in 17 Gene Ontology terms, mainly related to immune response (CD97, FYB, CXCL1, IKBKE, CCR1, etc.), inflammatory response (CD97, CXCL1, C3AR1, CCR1, LYZ, etc.) and homeostasis (C3AR1, CCR1, PLN, CCL19, PPT1, etc.). Two small-molecule drugs sanguinarine and papaverine were predicted to have a therapeutic effect against RA. Genes related to immune response, inflammatory response and homeostasis presumably have critical roles in RA pathogenesis. Sanguinarine and papaverine have a potential therapeutic effect against RA. Â© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. Analysis of the dynamic co-expression network of heart regeneration in the zebrafish Rodius, Sophie; Androsova, Ganna; GÃ¶tz, Lou; Liechti, Robin; Crespo, Isaac; Merz, Susanne; Nazarov, Petr V.; de Klein, Niek; Jeanty, CÃ©line; GonzÃ¡lez-Rosa, Juan M.; Muller, Arnaud; Bernardin, Francois; Niclou, Simone P.; Vallar, Laurent; Mercader, Nadia; Ibberson, Mark; Xenarios, Ioannis; Azuaje, Francisco The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration. Application of Weighted Gene Co-expression Network Analysis for Data from Paired Design. Li, Jianqiang; Zhou, Doudou; Qiu, Weiliang; Shi, Yuliang; Yang, Ji-Jiang; Chen, Shi; Wang, Qing; Pan, Hui Investigating how genes jointly affect complex human diseases is important, yet challenging. The network approach (e.g., weighted gene co-expression network analysis (WGCNA)) is a powerful tool. However, genomic data usually contain substantial batch effects, which could mask true genomic signals. Paired design is a powerful tool that can reduce batch effects. However, it is currently unclear how to appropriately apply WGCNA to genomic data from paired design. In this paper, we modified the current WGCNA pipeline to analyse high-throughput genomic data from paired design. We illustrated the modified WGCNA pipeline by analysing the miRNA dataset provided by Shiah et al. (2014), which contains forty oral squamous cell carcinoma (OSCC) specimens and their matched non-tumourous epithelial counterparts. OSCC is the sixth most common cancer worldwide. The modified WGCNA pipeline identified two sets of novel miRNAs associated with OSCC, in addition to the existing miRNAs reported by Shiah et al. (2014). Thus, this work will be of great interest to readers of various scientific disciplines, in particular, genetic and genomic scientists as well as medical scientists working on cancer. Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases. Kai Wang Full Text Available Co-expression networks are routinely used to study human diseases like obesity and diabetes. Systematic comparison of these networks between species has the potential to elucidate common mechanisms that are conserved between human and rodent species, as well as those that are species-specific characterizing evolutionary plasticity. We developed a semi-parametric meta-analysis approach for combining gene-gene co-expression relationships across expression profile datasets from multiple species. The simulation results showed that the semi-parametric method is robust against noise. When applied to human, mouse, and rat liver co-expression networks, our method out-performed existing methods in identifying gene pairs with coherent biological functions. We identified a network conserved across species that highlighted cell-cell signaling, cell-adhesion and sterol biosynthesis as main biological processes represented in genome-wide association study candidate gene sets for blood lipid levels. We further developed a heterogeneity statistic to test for network differences among multiple datasets, and demonstrated that genes with species-specific interactions tend to be under positive selection throughout evolution. Finally, we identified a human-specific sub-network regulated by RXRG, which has been validated to play a different role in hyperlipidemia and Type 2 diabetes between human and mouse. Taken together, our approach represents a novel step forward in integrating gene co-expression networks from multiple large scale datasets to leverage not only common information but also differences that are dataset-specific. A comprehensive analysis on preservation patterns of gene co-expression networks during Alzheimer's disease progression. Ray, Sumanta; Hossain, Sk Md Mosaddek; Khatun, Lutfunnesa; Mukhopadhyay, Anirban Alzheimer's disease (AD) is a chronic neuro-degenerative disruption of the brain which involves in large scale transcriptomic variation. The disease does not impact every regions of the brain at the same time, instead it progresses slowly involving somewhat sequential interaction with different regions. Analysis of the expression patterns of the genes in different regions of the brain influenced in AD surely contribute for a enhanced comprehension of AD pathogenesis and shed light on the early characterization of the disease. Here, we have proposed a framework to identify perturbation and preservation characteristics of gene expression patterns across six distinct regions of the brain ("EC", "HIP", "PC", "MTG", "SFG", and "VCX") affected in AD. Co-expression modules were discovered considering a couple of regions at once. These are then analyzed to know the preservation and perturbation characteristics. Different module preservation statistics and a rank aggregation mechanism have been adopted to detect the changes of expression patterns across brain regions. Gene ontology (GO) and pathway based analysis were also carried out to know the biological meaning of preserved and perturbed modules. In this article, we have extensively studied the preservation patterns of co-expressed modules in six distinct brain regions affected in AD. Some modules are emerged as the most preserved while some others are detected as perturbed between a pair of brain regions. Further investigation on the topological properties of preserved and non-preserved modules reveals a substantial association amongst "betweenness centrality" and "degree" of the involved genes. Our findings may render a deeper realization of the preservation characteristics of gene expression patterns in discrete brain regions affected by AD. Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses. Luo, Jie; Xu, Pei; Cao, Peijian; Wan, Hongjian; Lv, Xiaonan; Xu, Shengchun; Wang, Gangjun; Cook, Melloni N; Jones, Byron C; Lu, Lu; Wang, Xusheng Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear. The purpose of this study is to identify molecular networks underlying the effects of alcohol and stress responses, as well as their interaction on anxiety behaviors in the hippocampus of mice using a systems genetics approach. Here, we applied a gene co-expression network approach to transcriptomes of 41 BXD mouse strains under four conditions: stress, alcohol, stress-induced alcohol and control. The co-expression analysis identified 14 modules and characterized four expression patterns across the four conditions. The four expression patterns include up-regulation in no restraint stress and given an ethanol injection (NOE) but restoration in restraint stress followed by an ethanol injection (RSE; pattern 1), down-regulation in NOE but rescue in RSE (pattern 2), up-regulation in both restraint stress followed by a saline injection (RSS) and NOE, and further amplification in RSE (pattern 3), and up-regulation in RSS but reduction in both NOE and RSE (pattern 4). We further identified four functional subnetworks by superimposing protein-protein interactions (PPIs) to the 14 co-expression modules, including Î³-aminobutyric acid receptor (GABA) signaling, glutamate signaling, neuropeptide signaling, cAMP-dependent signaling. We further performed module specificity analysis to identify modules that are specific to stress, alcohol, or stress-induced alcohol responses. Finally, we conducted causality analysis to link genetic variation to these identified modules, and anxiety behaviors after stress and alcohol treatments. This study underscores the importance of integrative analysis and offers new insights into the molecular networks underlying stress and alcohol responses. Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses Jie Luo Full Text Available Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear. The purpose of this study is to identify molecular networks underlying the effects of alcohol and stress responses, as well as their interaction on anxiety behaviors in the hippocampus of mice using a systems genetics approach. Here, we applied a gene co-expression network approach to transcriptomes of 41 BXD mouse strains under four conditions: stress, alcohol, stress-induced alcohol and control. The co-expression analysis identified 14 modules and characterized four expression patterns across the four conditions. The four expression patterns include up-regulation in no restraint stress and given an ethanol injection (NOE but restoration in restraint stress followed by an ethanol injection (RSE; pattern 1, down-regulation in NOE but rescue in RSE (pattern 2, up-regulation in both restraint stress followed by a saline injection (RSS and NOE, and further amplification in RSE (pattern 3, and up-regulation in RSS but reduction in both NOE and RSE (pattern 4. We further identified four functional subnetworks by superimposing protein-protein interactions (PPIs to the 14 co-expression modules, including Î³-aminobutyric acid receptor (GABA signaling, glutamate signaling, neuropeptide signaling, cAMP-dependent signaling. We further performed module specificity analysis to identify modules that are specific to stress, alcohol, or stress-induced alcohol responses. Finally, we conducted causality analysis to link genetic variation to these identified modules, and anxiety behaviors after stress and alcohol treatments. This study underscores the importance of integrative analysis and offers new insights into the molecular networks underlying stress and alcohol responses. Weighted Gene Co-expression Network Analysis of the Dioscin Rich Medicinal Plant Dioscorea nipponica Full Text Available Dioscorea contains critically important species which can be used as staple foods or sources of bioactive substances, including Dioscorea nipponica, which has been used to develop highly successful drugs to treat cardiovascular disease. Its major active ingredients are thought to be sterol compounds such as diosgenin, which has been called â€œmedicinal goldâ€� because of its valuable properties. However, reliance on naturally growing plants as a production system limits the potential use of D. nipponica, raising interest in engineering metabolic pathways to enhance the production of secondary metabolites. However, the biosynthetic pathway of diosgenin is still poorly understood, and D. nipponica is poorly characterized at a molecular level, hindering in-depth investigation. In the present work, the RNAs from five organs and seven methyl jasmonate treated D. nipponica rhizomes were sequenced using the Illumina high-throughput sequencing platform, yielding 52 gigabases of data, which were pooled and assembled into a reference transcriptome. Four hundred and eighty two genes were found to be highly expressed in the rhizomes, and these genes are mainly involved in stress response and transcriptional regulation. Based on their expression patterns, 36 genes were selected for further investigation as candidate genes involved in dioscin biosynthesis. Constructing co-expression networks based on significant changes in gene expression revealed 15 gene modules. Of these, four modules with properties correlating to dioscin regulation and biosynthesis, consisting of 4,665 genes in total, were selected for further functional investigation. These results improve our understanding of dioscin biosynthesis in this important medicinal plant and will help guide more intensive investigations. In-silico gene co-expression network analysis in Paracoccidioides brasiliensis with reference to haloacid dehalogenase superfamily hydrolase gene Raghunath Satpathy Full Text Available Context: Paracoccidioides brasiliensis, a dimorphic fungus is the causative agent of paracoccidioidomycosis, a disease globally affecting millions of people. The haloacid dehalogenase (HAD superfamily hydrolases enzyme in the fungi, in particular, is known to be responsible in the pathogenesis by adhering to the tissue. Hence, identification of novel drug targets is essential. Aims: In-silico based identification of co-expressed genes along with HAD superfamily hydrolase in P. brasiliensis during the morphogenesis from mycelium to yeast to identify possible genes as drug targets. Materials and Methods: In total, four datasets were retrieved from the NCBI-gene expression omnibus (GEO database, each containing 4340 genes, followed by gene filtration expression of the data set. Further co-expression (CE study was performed individually and then a combination these genes were visualized in the Cytoscape 2. 8.3. Statistical Analysis Used: Mean and standard deviation value of the HAD superfamily hydrolase gene was obtained from the expression data and this value was subsequently used for the CE calculation purpose by selecting specific correlation power and filtering threshold. Results: The 23 genes that were thus obtained are common with respect to the HAD superfamily hydrolase gene. A significant network was selected from the Cytoscape network visualization that contains total 7 genes out of which 5 genes, which do not have significant protein hits, obtained from gene annotation of the expressed sequence tags by BLAST X. For all the protein PSI-BLAST was performed against human genome to find the homology. Conclusions: The gene co-expression network was obtained with respect to HAD superfamily dehalogenase gene in P. Brasiliensis. Weighted gene co-expression network analysis reveals potential genes involved in early metamorphosis process in sea cucumber Apostichopus japonicus. Li, Yongxin; Kikuchi, Mani; Li, Xueyan; Gao, Qionghua; Xiong, Zijun; Ren, Yandong; Zhao, Ruoping; Mao, Bingyu; Kondo, Mariko; Irie, Naoki; Wang, Wen Sea cucumbers, one main class of Echinoderms, have a very fast and drastic metamorphosis process during their development. However, the molecular basis under this process remains largely unknown. Here we systematically examined the gene expression profiles of Japanese common sea cucumber (Apostichopus japonicus) for the first time by RNA sequencing across 16 developmental time points from fertilized egg to juvenile stage. Based on the weighted gene co-expression network analysis (WGCNA), we identified 21 modules. Among them, MEdarkmagenta was highly expressed and correlated with the early metamorphosis process from late auricularia to doliolaria larva. Furthermore, gene enrichment and differentially expressed gene analysis identified several genes in the module that may play key roles in the metamorphosis process. Our results not only provide a molecular basis for experimentally studying the development and morphological complexity of sea cucumber, but also lay a foundation for improving its emergence rate. Copyright Â© 2017 Elsevier Inc. All rights reserved. Comprehensive analysis of coding-lncRNA gene co-expression network uncovers conserved functional lncRNAs in zebrafish. Chen, Wen; Zhang, Xuan; Li, Jing; Huang, Shulan; Xiang, Shuanglin; Hu, Xiang; Liu, Changning Zebrafish is a full-developed model system for studying development processes and human disease. Recent studies of deep sequencing had discovered a large number of long non-coding RNAs (lncRNAs) in zebrafish. However, only few of them had been functionally characterized. Therefore, how to take advantage of the mature zebrafish system to deeply investigate the lncRNAs' function and conservation is really intriguing. We systematically collected and analyzed a series of zebrafish RNA-seq data, then combined them with resources from known database and literatures. As a result, we obtained by far the most complete dataset of zebrafish lncRNAs, containing 13,604 lncRNA genes (21,128 transcripts) in total. Based on that, a co-expression network upon zebrafish coding and lncRNA genes was constructed and analyzed, and used to predict the Gene Ontology (GO) and the KEGG annotation of lncRNA. Meanwhile, we made a conservation analysis on zebrafish lncRNA, identifying 1828 conserved zebrafish lncRNA genes (1890 transcripts) that have their putative mammalian orthologs. We also found that zebrafish lncRNAs play important roles in regulation of the development and function of nervous system; these conserved lncRNAs present a significant sequential and functional conservation, with their mammalian counterparts. By integrative data analysis and construction of coding-lncRNA gene co-expression network, we gained the most comprehensive dataset of zebrafish lncRNAs up to present, as well as their systematic annotations and comprehensive analyses on function and conservation. Our study provides a reliable zebrafish-based platform to deeply explore lncRNA function and mechanism, as well as the lncRNA commonality between zebrafish and human. Genetic architecture of wood properties based on association analysis and co-expression networks in white spruce. Lamara, Mebarek; Raherison, Elie; Lenz, Patrick; Beaulieu, Jean; Bousquet, Jean; MacKay, John Association studies are widely utilized to analyze complex traits but their ability to disclose genetic architectures is often limited by statistical constraints, and functional insights are usually minimal in nonmodel organisms like forest trees. We developed an approach to integrate association mapping results with co-expression networks. We tested single nucleotide polymorphisms (SNPs) in 2652 candidate genes for statistical associations with wood density, stiffness, microfibril angle and ring width in a population of 1694 white spruce trees (Picea glauca). Associations mapping identified 229-292 genes per wood trait using a statistical significance level of P wood associated genes and several known MYB and NAC regulators were identified as network hubs. The network revealed a link between the gene PgNAC8, wood stiffness and microfibril angle, as well as considerable within-season variation for both genetic control of wood traits and gene expression. Trait associations were distributed throughout the network suggesting complex interactions and pleiotropic effects. Our findings indicate that integration of association mapping and co-expression networks enhances our understanding of complex wood traits. Â© 2015 The Authors. New Phytologist Â© 2015 New Phytologist Trust. Profiling and Co-expression Network Analysis of Learned Helplessness Regulated mRNAs and lncRNAs in the Mouse Hippocampus Chaoqun Li Full Text Available Although studies provide insights into the neurobiology of stress and depression, the exact molecular mechanisms underlying their pathologies remain largely unknown. Long non-coding RNA (lncRNA has been implicated in brain functions and behavior. A potential link between lncRNA and psychiatric disorders has been proposed. However, it remains undetermined whether IncRNA regulation, in the brain, contributes to stress or depression pathologies. In this study, we used a valid animal model of depression-like symptoms; namely learned helplessness, RNA-seq, Gene Ontology and co-expression network analyses to profile the expression pattern of lncRNA and mRNA in the hippocampus of mice. We identified 6346 differentially expressed transcripts. Among them, 340 lncRNAs and 3559 protein coding mRNAs were differentially expressed in helpless mice in comparison with control and/or non-helpless mice (inescapable stress resilient mice. Gene Ontology and pathway enrichment analyses indicated that induction of helplessness altered expression of mRNAs enriched in fundamental biological functions implicated in stress/depression neurobiology such as synaptic, metabolic, cell survival and proliferation, developmental and chromatin modification functions. To explore the possible regulatory roles of the altered lncRNAs, we constructed co-expression networks composed of the lncRNAs and mRNAs. Among our differentially expressed lncRNAs, 17% showed significant correlation with genes. Functional co-expression analysis linked the identified lncRNAs to several cellular mechanisms implicated in stress/depression neurobiology. Importantly, 57% of the identified regulatory lncRNAs significantly correlated with 18 different synapse-related functions. Thus, the current study identifies for the first time distinct groups of lncRNAs regulated by induction of learned helplessness in the mouse brain. Our results suggest that lncRNA-directed regulatory mechanisms might contribute to Profiling and Co-expression Network Analysis of Learned Helplessness Regulated mRNAs and lncRNAs in the Mouse Hippocampus. Li, Chaoqun; Cao, Feifei; Li, Shengli; Huang, Shenglin; Li, Wei; Abumaria, Nashat Although studies provide insights into the neurobiology of stress and depression, the exact molecular mechanisms underlying their pathologies remain largely unknown. Long non-coding RNA (lncRNA) has been implicated in brain functions and behavior. A potential link between lncRNA and psychiatric disorders has been proposed. However, it remains undetermined whether IncRNA regulation, in the brain, contributes to stress or depression pathologies. In this study, we used a valid animal model of depression-like symptoms; namely learned helplessness, RNA-seq, Gene Ontology and co-expression network analyses to profile the expression pattern of lncRNA and mRNA in the hippocampus of mice. We identified 6346 differentially expressed transcripts. Among them, 340 lncRNAs and 3559 protein coding mRNAs were differentially expressed in helpless mice in comparison with control and/or non-helpless mice (inescapable stress resilient mice). Gene Ontology and pathway enrichment analyses indicated that induction of helplessness altered expression of mRNAs enriched in fundamental biological functions implicated in stress/depression neurobiology such as synaptic, metabolic, cell survival and proliferation, developmental and chromatin modification functions. To explore the possible regulatory roles of the altered lncRNAs, we constructed co-expression networks composed of the lncRNAs and mRNAs. Among our differentially expressed lncRNAs, 17% showed significant correlation with genes. Functional co-expression analysis linked the identified lncRNAs to several cellular mechanisms implicated in stress/depression neurobiology. Importantly, 57% of the identified regulatory lncRNAs significantly correlated with 18 different synapse-related functions. Thus, the current study identifies for the first time distinct groups of lncRNAs regulated by induction of learned helplessness in the mouse brain. Our results suggest that lncRNA-directed regulatory mechanisms might contribute to stress In silico identification of miRNAs and their target genes and analysis of gene co-expression network in saffron (Crocus sativus L.) stigma Zinati, Zahra; Shamloo-Dashtpagerdi, Roohollah; Behpouri, Ali As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characterization of miRNAs along with the corresponding target genes in C. sativus might expand our perspectives on the roles of miRNAs in carotenoid/apocarotenoid biosynthetic pathway. A computational analysis was used to identify miRNAs and their targets using EST (Expressed Sequence Tag) library from mature saffron stigmas. Then, a gene co- expression network was constructed to identify genes which are potentially involved in carotenoid/apocarotenoid biosynthetic pathways. EST analysis led to the identification of two putative miRNAs (miR414 and miR837-5p) along with the corresponding stem- looped precursors. To our knowledge, this is the first report on miR414 and miR837-5p in C. sativus. Co-expression network analysis indicated that miR414 and miR837-5p may play roles in C. sativus metabolic pathways and led to identification of candidate genes including six transcription factors and one protein kinase probably involved in carotenoid/apocarotenoid biosynthetic pathway. Presence of transcription factors, miRNAs and protein kinase in the network indicated multiple layers of regulation in saffron stigma. The candidate genes from this study may help unraveling regulatory networks underlying the carotenoid/apocarotenoid biosynthesis in saffron and designing metabolic engineering for enhanced secondary metabolites. PMID:28261627 Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules. Xiao, Xiaolin; Moreno-Moral, Aida; Rotival, Maxime; Bottolo, Leonardo; Petretto, Enrico Recent high-throughput efforts such as ENCODE have generated a large body of genome-scale transcriptional data in multiple conditions (e.g., cell-types and disease states). Leveraging these data is especially important for network-based approaches to human disease, for instance to identify coherent transcriptional modules (subnetworks) that can inform functional disease mechanisms and pathological pathways. Yet, genome-scale network analysis across conditions is significantly hampered by the paucity of robust and computationally-efficient methods. Building on the Higher-Order Generalized Singular Value Decomposition, we introduce a new algorithmic approach for efficient, parameter-free and reproducible identification of network-modules simultaneously across multiple conditions. Our method can accommodate weighted (and unweighted) networks of any size and can similarly use co-expression or raw gene expression input data, without hinging upon the definition and stability of the correlation used to assess gene co-expression. In simulation studies, we demonstrated distinctive advantages of our method over existing methods, which was able to recover accurately both common and condition-specific network-modules without entailing ad-hoc input parameters as required by other approaches. We applied our method to genome-scale and multi-tissue transcriptomic datasets from rats (microarray-based) and humans (mRNA-sequencing-based) and identified several common and tissue-specific subnetworks with functional significance, which were not detected by other methods. In humans we recapitulated the crosstalk between cell-cycle progression and cell-extracellular matrix interactions processes in ventricular zones during neocortex expansion and further, we uncovered pathways related to development of later cognitive functions in the cortical plate of the developing brain which were previously unappreciated. Analyses of seven rat tissues identified a multi-tissue subnetwork of co-expressed Xiaolin Xiao Full Text Available Recent high-throughput efforts such as ENCODE have generated a large body of genome-scale transcriptional data in multiple conditions (e.g., cell-types and disease states. Leveraging these data is especially important for network-based approaches to human disease, for instance to identify coherent transcriptional modules (subnetworks that can inform functional disease mechanisms and pathological pathways. Yet, genome-scale network analysis across conditions is significantly hampered by the paucity of robust and computationally-efficient methods. Building on the Higher-Order Generalized Singular Value Decomposition, we introduce a new algorithmic approach for efficient, parameter-free and reproducible identification of network-modules simultaneously across multiple conditions. Our method can accommodate weighted (and unweighted networks of any size and can similarly use co-expression or raw gene expression input data, without hinging upon the definition and stability of the correlation used to assess gene co-expression. In simulation studies, we demonstrated distinctive advantages of our method over existing methods, which was able to recover accurately both common and condition-specific network-modules without entailing ad-hoc input parameters as required by other approaches. We applied our method to genome-scale and multi-tissue transcriptomic datasets from rats (microarray-based and humans (mRNA-sequencing-based and identified several common and tissue-specific subnetworks with functional significance, which were not detected by other methods. In humans we recapitulated the crosstalk between cell-cycle progression and cell-extracellular matrix interactions processes in ventricular zones during neocortex expansion and further, we uncovered pathways related to development of later cognitive functions in the cortical plate of the developing brain which were previously unappreciated. Analyses of seven rat tissues identified a multi Comparative transcriptome and gene co-expression network analysis reveal genes and signaling pathways adaptively responsive to varied adverse stresses in the insect fungal pathogen, Beauveria bassiana. He, Zhangjiang; Zhao, Xin; Lu, Zhuoyue; Wang, Huifang; Liu, Pengfei; Zeng, Fanqin; Zhang, Yongjun Sensing, responding, and adapting to the surrounding environment are crucial for all living organisms to survive, proliferate, and differentiate in their biological niches. Beauveria bassiana is an economically important insect-pathogenic fungus which is widely used as a biocontrol agent to control a variety of insect pests. The fungal pathogen unavoidably encounters a variety of adverse environmental stresses and defense response from the host insects during application of the fungal agents. However, few are known about the transcription response of the fungus to respond or adapt varied adverse stresses. Here, we comparatively analyzed the transcriptome of B. bassiana in globe genome under the varied stationary-phase stresses including osmotic agent (0.8â€¯M NaCl), high temperature (32â€¯Â°C), cell wall-perturbing agent (Congo red), and oxidative agents (H 2 O 2 or menadione). Total of 12,412 reads were obtained, and mapped to the 6767 genes of the B. bassiana. All of these stresses caused transcription responses involved in basal metabolism, cell wall construction, stress response or cell rescue/detoxification, signaling transduction and gene transcription regulation, and likely other cellular processes. An array of genes displayed similar transcription patterns in response to at least two of the five stresses, suggesting a shared transcription response to varied adverse stresses. Gene co-expression network analysis revealed that mTOR signaling pathway, but not HOG1 MAP kinase pathway, played a central role in regulation the varied adverse stress responses, which was verified by RNAi-mediated knockdown of TOR1. Our findings provided an insight of transcription response and gene co-expression network of B. bassiana in adaptation to varied environments. Copyright Â© 2017 Elsevier Inc. All rights reserved. Building gene co-expression networks using transcriptomics data for systems biology investigations Kadarmideen, Haja; Watson-Haigh, Nathan S. Gene co-expression networks (GCN), built using high-throughput gene expression data are fundamental aspects of systems biology. The main aims of this study were to compare two popular approaches to building and analysing GCN. We use real ovine microarray transcriptomics datasets representing four......) is connected within a network. The two GCN construction methods used were, Weighted Gene Co-expression Network Analysis (WGCNA) and Partial Correlation and Information Theory (PCIT) methods. Nodes were ranked based on their connectivity measures in each of the four different networks created by WGCNA and PCIT...... (with > 20000 genes) access to large computer clusters, particularly those with larger amounts of shared memory is recommended.... Elucidating gene function and function evolution through comparison of co-expression networks in plants Marek eMutwil Full Text Available The analysis of gene expression data has shown that transcriptionally coordinated (co-expressed genes are often functionally related, enabling scientists to use expression data in gene function prediction. This Focused Review discusses our original paper (Large-scale co-expression approach to dissect secondary cell wall formation across plant species, Frontiers in Plant Science 2:23. In this paper we applied cross-species analysis to co-expression networks of genes involved in cellulose biosynthesis. We show that the co-expression networks from different species are highly similar, indicating that whole biological pathways are conserved across species. This finding has two important implications. First, the analysis can transfer gene function annotation from well-studied plants, such as Arabidopsis, to other, uncharacterized plant species. As the analysis finds genes that have similar sequence and similar expression pattern across different organisms, functionally equivalent genes can be identified. Second, since co-expression analyses are often noisy, a comparative analysis should have higher performance, as parts of co-expression networks that are conserved are more likely to be functionally relevant. In this Focused Review, we outline the comparative analysis done in the original paper and comment on the recent advances and approaches that allow comparative analyses of co-function networks. We hypothesize that, in comparison to simple co-expression analysis, comparative analysis would yield more accurate gene function predictions. Finally, by combining comparative analysis with genomic information of green plants, we propose a possible composition of cellulose biosynthesis machinery during earlier stages of plant evolution. Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. Wang, Weijing; Jiang, Wenjie; Hou, Lin; Duan, Haiping; Wu, Yili; Xu, Chunsheng; Tan, Qihua; Li, Shuxia; Zhang, Dongfeng The therapeutic management of obesity is challenging, hence further elucidating the underlying mechanisms of obesity development and identifying new diagnostic biomarkers and therapeutic targets are urgent and necessary. Here, we performed differential gene expression analysis and weighted gene co-expression network analysis (WGCNA) to identify significant genes and specific modules related to BMI based on gene expression profile data of 7 discordant monozygotic twins. In the differential gene expression analysis, it appeared that 32 differentially expressed genes (DEGs) were with a trend of up-regulation in twins with higher BMI when compared to their siblings. Categories of positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of NF-kappa B import into nucleus, and peroxidase activity were significantly enriched within GO database and NF-kappa B signaling pathway within KEGG database. DEGs of NAMPT, TLR9, PTGS2, HBD, and PCSK1N might be associated with obesity. In the WGCNA, among the total 20 distinct co-expression modules identified, coral1 module (68 genes) had the strongest positive correlation with BMI (râ€‰=â€‰0.56, Pâ€‰=â€‰0.04) and disease status (râ€‰=â€‰0.56, Pâ€‰=â€‰0.04). Categories of positive regulation of phospholipase activity, high-density lipoprotein particle clearance, chylomicron remnant clearance, reverse cholesterol transport, intermediate-density lipoprotein particle, chylomicron, low-density lipoprotein particle, very-low-density lipoprotein particle, voltage-gated potassium channel complex, cholesterol transporter activity, and neuropeptide hormone activity were significantly enriched within GO database for this module. And alcoholism and cell adhesion molecules pathways were significantly enriched within KEGG database. Several hub genes, such as GAL, ASB9, NPPB, TBX2, IL17C, APOE, ABCG4, and APOC2 were also identified. The module eigengene of saddlebrown module (212 genes) was also significantly Dissection of regulatory networks that are altered in disease via differential co-expression. David Amar Full Text Available Comparing the gene-expression profiles of sick and healthy individuals can help in understanding disease. Such differential expression analysis is a well-established way to find gene sets whose expression is altered in the disease. Recent approaches to gene-expression analysis go a step further and seek differential co-expression patterns, wherein the level of co-expression of a set of genes differs markedly between disease and control samples. Such patterns can arise from a disease-related change in the regulatory mechanism governing that set of genes, and pinpoint dysfunctional regulatory networks. Here we present DICER, a new method for detecting differentially co-expressed gene sets using a novel probabilistic score for differential correlation. DICER goes beyond standard differential co-expression and detects pairs of modules showing differential co-expression. The expression profiles of genes within each module of the pair are correlated across all samples. The correlation between the two modules, however, differs markedly between the disease and normal samples. We show that DICER outperforms the state of the art in terms of significance and interpretability of the detected gene sets. Moreover, the gene sets discovered by DICER manifest regulation by disease-specific microRNA families. In a case study on Alzheimer's disease, DICER dissected biological processes and protein complexes into functional subunits that are differentially co-expressed, thereby revealing inner structures in disease regulatory networks. Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis Full Text Available Xian-guo Zhou,1,2,* Xiao-liang Huang,1,2,* Si-yuan Liang,1â€“3 Shao-mei Tang,1,2 Si-kao Wu,1,2 Tong-tong Huang,1,2 Zeng-nan Mo,1,2,4 Qiu-yan Wang1,2,5 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, Peopleâ€™s Republic of China; 2Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi Zhuang Autonomous Region, Peopleâ€™s Republic of China; 3Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, Peopleâ€™s Republic of China; 4Department of Urology and Nephrology, The First Affiliated Hospital of Guangxi, Medical University, Nanning, Guangxi Zhuang Autonomous Region, Peopleâ€™s Republic of China; 5Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, Peopleâ€™s Republic of China These authors contributed equally to this work Introduction: Colorectal cancer (CRC is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA and gene modules or representative biomarkers related to the pathological stage of colon cancer helps to predict prognosis and reveal the mechanisms behind cancer progression.Materials and methods: We applied a systems biology approach by combining differential expression analysis and weighted gene co-expression network analysis (WGCNA to detect the pathological stage-related miRNA and gene modules and construct a miRNAâ€“gene network. The Cancer Genome Atlas (TCGA colon adenocarcinoma (CAC RNA-sequencing data and miRNA-sequencing data were subjected to WGCNA analysis, and the GSE29623, GSE35602 and GSE39396 were utilized to validate and Microarray profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder. Zhifen Liu Full Text Available LncRNAs, which represent one of the most highly expressed classes of ncRNAs in the brain, are becoming increasingly interesting with regard to brain functions and disorders. However, changes in the expression of regulatory lncRNAs in Major Depressive Disorder (MDD have not yet been reported. Using microarrays, we profiled the expression of 34834 lncRNAs and 39224 mRNAs in peripheral blood sampled from MDD patients as well as demographically-matched controls. Among these, we found that 2007 lncRNAs and 1667 mRNAs were differentially expressed, 17 of which were documented as depression-related gene in previous studies. Gene Ontology (GO and pathway analyses indicated that the biological functions of differentially expressed mRNAs were related to fundamental metabolic processes and neurodevelopment diseases. To investigate the potential regulatory roles of the differentially expressed lncRNAs on the mRNAs, we also constructed co-expression networks composed of the lncRNAs and mRNAs, which shows significant correlated patterns of expression. In the MDD-derived network, there were a greater number of nodes and connections than that in the control-derived network. The lncRNAs located at chr10:874695-874794, chr10:75873456-75873642, and chr3:47048304-47048512 may be important factors regulating the expression of mRNAs as they have previously been reported associations with MDD. This study is the first to explore genome-wide lncRNA expression and co-expression with mRNA patterns in MDD using microarray technology. We identified circulating lncRNAs that are aberrantly expressed in MDD and the results suggest that lncRNAs may contribute to the molecular pathogenesis of MDD. Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy Oyang Yen-Jen Full Text Available Abstract Background Molecular networks represent the backbone of molecular activity within cells and provide opportunities for understanding the mechanism of diseases. While protein-protein interaction data constitute static network maps, integration of condition-specific co-expression information provides clues to the dynamic features of these networks. Dilated cardiomyopathy is a leading cause of heart failure. Although previous studies have identified putative biomarkers or therapeutic targets for heart failure, the underlying molecular mechanism of dilated cardiomyopathy remains unclear. Results We developed a network-based comparative analysis approach that integrates protein-protein interactions with gene expression profiles and biological function annotations to reveal dynamic functional modules under different biological states. We found that hub proteins in condition-specific co-expressed protein interaction networks tended to be differentially expressed between biological states. Applying this method to a cohort of heart failure patients, we identified two functional modules that significantly emerged from the interaction networks. The dynamics of these modules between normal and disease states further suggest a potential molecular model of dilated cardiomyopathy. Conclusions We propose a novel framework to analyze the interaction networks in different biological states. It successfully reveals network modules closely related to heart failure; more importantly, these network dynamics provide new insights into the cause of dilated cardiomyopathy. The revealed molecular modules might be used as potential drug targets and provide new directions for heart failure therapy. Network statistics of genetically-driven gene co-expression modules in mouse crosses Marie-Pier eScott-Boyer Full Text Available In biology, networks are used in different contexts as ways to represent relationships between entities, such as for instance interactions between genes, proteins or metabolites. Despite progress in the analysis of such networks and their potential to better understand the collective impact of genes on complex traits, one remaining challenge is to establish the biologic validity of gene co-expression networks and to determine what governs their organization. We used WGCNA to construct and analyze seven gene expression datasets from several tissues of mouse recombinant inbred strains (RIS. For six out of the 7 networks, we found that linkage to module QTLs (mQTLs could be established for 29.3% of gene co-expression modules detected in the several mouse RIS. For about 74.6% of such genetically-linked modules, the mQTL was on the same chromosome as the one contributing most genes to the module, with genes originating from that chromosome showing higher connectivity than other genes in the modules. Such modules (that we considered as genetically-driven had network statistic properties (density, centralization and heterogeneity that set them apart from other modules in the network. Altogether, a sizeable portion of gene co-expression modules detected in mouse RIS panels had genetic determinants as their main organizing principle. In addition to providing a biologic interpretation validation for these modules, these genetic determinants imparted on them particular properties that set them apart from other modules in the network, to the point that they can be predicted to a large extent on the basis of their network statistics. Co-expression Network Approach to Studying the Effects of Botulinum Neurotoxin-A. Mukund, Kavitha; Ward, Samuel R; Lieber, Richard L; Subramaniam, Shankar Botulinum Neurotoxin A (BoNT-A) is a potent neurotoxin with several clinical applications.The goal of this study was to utilize co-expression network theory to analyze temporal transcriptional data from skeletal muscle after BoNT-A treatment. Expression data for 2000 genes (extracted using a ranking heuristic) served as the basis for this analysis. Using weighted gene co-expression network analysis (WGCNA), we identified 19 co-expressed modules, further hierarchically clustered into 5 groups. Quantifying average expression and co-expression patterns across these groups revealed temporal aspects of muscle's response to BoNT-A. Functional analysis revealed enrichment of group 1 with metabolism; group 5 with contradictory functions of atrophy and cellular recovery; and groups 2 and 3 with extracellular matrix (ECM) and non-fast fiber isoforms. Topological positioning of two highly ranked, significantly expressed genes- Dclk1 and Ostalpha within group 5 suggested possible mechanistic roles in recovery from BoNT-A induced atrophy. Phenotypic correlations of groups with titin and myosin protein content further emphasized the effect of BoNT-A on the sarcomeric contraction machinery in early phase of chemodenervation. In summary, our approach revealed a hierarchical functional response to BoNT-A induced paralysis with early metabolic and later ECM responses and identified putative biomarkers associated with chemodenervation. Additionally, our results provide an unbiased validation of the response documented in our previous workBotulinum Neurotoxin A (BoNT-A) is a potent neurotoxin with several clinical applications.The goal of this study was to utilize co-expression network theory to analyze temporal transcriptional data from skeletal muscle after BoNT-A treatment. Expression data for 2000 genes (extracted using a ranking heuristic) served as the basis for this analysis. Using weighted gene co-expression network analysis (WGCNA), we identified 19 co-expressed modules Uncovering co-expression gene network modules regulating fruit acidity in diverse apples. Bai, Yang; Dougherty, Laura; Cheng, Lailiang; Zhong, Gan-Yuan; Xu, Kenong Acidity is a major contributor to fruit quality. Several organic acids are present in apple fruit, but malic acid is predominant and determines fruit acidity. The trait is largely controlled by the Malic acid (Ma) locus, underpinning which Ma1 that putatively encodes a vacuolar aluminum-activated malate transporter1 (ALMT1)-like protein is a strong candidate gene. We hypothesize that fruit acidity is governed by a gene network in which Ma1 is key member. The goal of this study is to identify the gene network and the potential mechanisms through which the network operates. Guided by Ma1, we analyzed the transcriptomes of mature fruit of contrasting acidity from six apple accessions of genotype Ma_ (MaMa or Mama) and four of mama using RNA-seq and identified 1301 fruit acidity associated genes, among which 18 were most significant acidity genes (MSAGs). Network inferring using weighted gene co-expression network analysis (WGCNA) revealed five co-expression gene network modules of significant (Pâ€‰acidity. Overall, this study provides important insight into the Ma1-mediated gene network controlling acidity in mature apple fruit of diverse genetic background. Effects of threshold on the topology of gene co-expression networks. Couto, Cynthia Martins Villar; Comin, CÃ©sar Henrique; Costa, Luciano da Fontoura Several developments regarding the analysis of gene co-expression profiles using complex network theory have been reported recently. Such approaches usually start with the construction of an unweighted gene co-expression network, therefore requiring the selection of a suitable threshold defining which pairs of vertices will be connected. We aimed at addressing such an important problem by suggesting and comparing five different approaches for threshold selection. Each of the methods considers a respective biologically-motivated criterion for electing a potentially suitable threshold. A set of 21 microarray experiments from different biological groups was used to investigate the effect of applying the five proposed criteria to several biological situations. For each experiment, we used the Pearson correlation coefficient to measure the relationship between each gene pair, and the resulting weight matrices were thresholded considering several values, generating respective adjacency matrices (co-expression networks). Each of the five proposed criteria was then applied in order to select the respective threshold value. The effects of these thresholding approaches on the topology of the resulting networks were compared by using several measurements, and we verified that, depending on the database, the impact on the topological properties can be large. However, a group of databases was verified to be similarly affected by most of the considered criteria. Based on such results, it can be suggested that when the generated networks present similar measurements, the thresholding method can be chosen with greater freedom. If the generated networks are markedly different, the thresholding method that better suits the interests of each specific research study represents a reasonable choice. Characterization of differentially expressed genes using high-dimensional co-expression networks Coelho Goncalves de Abreu, Gabriel; Labouriau, Rodrigo S. We present a technique to characterize differentially expressed genes in terms of their position in a high-dimensional co-expression network. The set-up of Gaussian graphical models is used to construct representations of the co-expression network in such a way that redundancy and the propagation...... that allow to make effective inference in problems with high degree of complexity (e.g. several thousands of genes) and small number of observations (e.g. 10-100) as typically occurs in high throughput gene expression studies. Taking advantage of the internal structure of decomposable graphical models, we...... construct a compact representation of the co-expression network that allows to identify the regions with high concentration of differentially expressed genes. It is argued that differentially expressed genes located in highly interconnected regions of the co-expression network are less informative than... Relation of Transcriptional Factors to the Expression and Activity of Cytochrome P450 and UDP-Glucuronosyltransferases 1A in Human Liver: Co-Expression Network Analysis. Zhong, Shilong; Han, Weichao; Hou, Chuqi; Liu, Junjin; Wu, Lili; Liu, Menghua; Liang, Zhi; Lin, Haoming; Zhou, Lili; Liu, Shuwen; Tang, Lan Cytochrome P450 (CYPs) and UDP-glucuronosyltransferases (UGTs) play important roles in the metabolism of exogenous and endogenous compounds. The gene transcription of CYPs and UGTs can be enhanced or reduced by transcription factors (TFs). This study aims to explore novel TFs involved in the regulatory network of human hepatic UGTs/CYPs. Correlations between the transcription levels of 683 key TFs and CYPs/UGTs in three different human liver expression profiles (nâ€‰=â€‰640) were calculated first. Supervised weighted correlation network analysis (sWGCNA) was employed to define hub genes among the selected TFs. The relationship among 17 defined TFs, CYPs/UGTs expression, and activity were evaluated in 30 liver samples from Chinese patients. The positive controls (e.g., PPARA, NR1I2, NR1I3) and hub TFs (NFIA, NR3C2, and AR) in the Grey sWGCNA Module were significantly and positively associated with CYPs/UGTs expression. And the cancer- or inflammation-related TFs (TEAD4, NFKB2, and NFKB1) were negatively associated with mRNA expression of CYP2C9/CYP2E1/UGT1A9. Furthermore, the effect of NR1I2, NR1I3, AR, TEAD4, and NFKB2 on CYP450/UGT1A gene transcription translated into moderate influences on enzyme activities. To our knowledge, this is the first study to integrate Gene Expression Omnibus (GEO) datasets and supervised weighted correlation network analysis (sWGCNA) for defining TFs potentially related to CYPs/UGTs. We detected several novel TFs involved in the regulatory network of hepatic CYPs and UGTs in humans. Further validation and investigation may reveal their exact mechanism of CYPs/UGTs regulation. Estimation of the proteomic cancer co-expression sub networks by using association estimators. Cihat ErdoÄŸan Full Text Available In this study, the association estimators, which have significant influences on the gene network inference methods and used for determining the molecular interactions, were examined within the co-expression network inference concept. By using the proteomic data from five different cancer types, the hub genes/proteins within the disease-associated gene-gene/protein-protein interaction sub networks were identified. Proteomic data from various cancer types is collected from The Cancer Proteome Atlas (TCPA. Correlation and mutual information (MI based nine association estimators that are commonly used in the literature, were compared in this study. As the gold standard to measure the association estimators' performance, a multi-layer data integration platform on gene-disease associations (DisGeNET and the Molecular Signatures Database (MSigDB was used. Fisher's exact test was used to evaluate the performance of the association estimators by comparing the created co-expression networks with the disease-associated pathways. It was observed that the MI based estimators provided more successful results than the Pearson and Spearman correlation approaches, which are used in the estimation of biological networks in the weighted correlation network analysis (WGCNA package. In correlation-based methods, the best average success rate for five cancer types was 60%, while in MI-based methods the average success ratio was 71% for James-Stein Shrinkage (Shrink and 64% for Schurmann-Grassberger (SG association estimator, respectively. Moreover, the hub genes and the inferred sub networks are presented for the consideration of researchers and experimentalists. Gene Co-expression Analysis to Characterize Genes Related to Marbling Trait in Hanwoo (Korean) Cattle. Lim, Dajeong; Lee, Seung-Hwan; Kim, Nam-Kuk; Cho, Yong-Min; Chai, Han-Ha; Seong, Hwan-Hoo; Kim, Heebal Marbling (intramuscular fat) is an important trait that affects meat quality and is a casual factor determining the price of beef in the Korean beef market. It is a complex trait and has many biological pathways related to muscle and fat. There is a need to identify functional modules or genes related to marbling traits and investigate their relationships through a weighted gene co-expression network analysis based on the system level. Therefore, we investigated the co-expression relationships of genes related to the 'marbling score' trait and systemically analyzed the network topology in Hanwoo (Korean cattle). As a result, we determined 3 modules (gene groups) that showed statistically significant results for marbling score. In particular, one module (denoted as red) has a statistically significant result for marbling score (p = 0.008) and intramuscular fat (p = 0.02) and water capacity (p = 0.006). From functional enrichment and relationship analysis of the red module, the pathway hub genes (IL6, CHRNE, RB1, INHBA and NPPA) have a direct interaction relationship and share the biological functions related to fat or muscle, such as adipogenesis or muscle growth. This is the first gene network study with m.logissimus in Hanwoo to observe co-expression patterns in divergent marbling phenotypes. It may provide insights into the functional mechanisms of the marbling trait. Gene Co-expression Analysis to Characterize Genes Related to Marbling Trait in Hanwoo (Korean Cattle Dajeong Lim Full Text Available Marbling (intramuscular fat is an important trait that affects meat quality and is a casual factor determining the price of beef in the Korean beef market. It is a complex trait and has many biological pathways related to muscle and fat. There is a need to identify functional modules or genes related to marbling traits and investigate their relationships through a weighted gene co-expression network analysis based on the system level. Therefore, we investigated the co-expression relationships of genes related to the â€˜marbling scoreâ€™ trait and systemically analyzed the network topology in Hanwoo (Korean cattle. As a result, we determined 3 modules (gene groups that showed statistically significant results for marbling score. In particular, one module (denoted as red has a statistically significant result for marbling score (p = 0.008 and intramuscular fat (p = 0.02 and water capacity (p = 0.006. From functional enrichment and relationship analysis of the red module, the pathway hub genes (IL6, CHRNE, RB1, INHBA and NPPA have a direct interaction relationship and share the biological functions related to fat or muscle, such as adipogenesis or muscle growth. This is the first gene network study with m.logissimus in Hanwoo to observe co-expression patterns in divergent marbling phenotypes. It may provide insights into the functional mechanisms of the marbling trait. Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis. Han, Xinxin; Yin, Linlin; Xue, Hongwei Fatty acids (FAs) play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosynthesis genes including de novo synthases, desaturases and elongases were selected as "guide genes" to construct the co-expression network. Calculation of the correlation between all Arabidopsis thaliana (L.) genes with each guide gene by Arabidopsis co-expression dating mining tools (ACT) identifies 797 candidate FA-correlated genes. Gene ontology (GO) analysis of these co-expressed genes showed they are tightly correlated to photosynthesis and carbohydrate metabolism, and function in many processes. Interestingly, 63 transcription factors (TFs) were identified as candidate FA biosynthesis regulators and 8 TF families are enriched. Two TF genes, CRC and AP1, both correlating with 8 FA guide genes, were further characterized. Analyses of the ap1 and crc mutant showed the altered total FA composition of mature seeds. The contents of palmitoleic acid, stearic acid, arachidic acid and eicosadienoic acid are decreased, whereas that of oleic acid is increased in ap1 and crc seeds, which is consistent with the qRT-PCR analysis revealing the suppressed expression of the corresponding guide genes. In addition, yeast one-hybrid analysis and electrophoretic mobility shift assay (EMSA) revealed that CRC can bind to the promoter regions of KCS7 and KCS15, indicating that CRC may directly regulate FA biosynthesis. Â© 2012 Institute of Botany, Chinese Academy of Sciences. An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks. BotÃa, Juan A; Vandrovcova, Jana; Forabosco, Paola; Guelfi, Sebastian; D'Sa, Karishma; Hardy, John; Lewis, Cathryn M; Ryten, Mina; Weale, Michael E Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used R software package for the generation of gene co-expression networks (GCN). WGCNA generates both a GCN and a derived partitioning of clusters of genes (modules). We propose k-means clustering as an additional processing step to conventional WGCNA, which we have implemented in the R package km2gcn (k-means to gene co-expression network, https://github.com/juanbot/km2gcn ). We assessed our method on networks created from UKBEC data (10 different human brain tissues), on networks created from GTEx data (42 human tissues, including 13 brain tissues), and on simulated networks derived from GTEx data. We observed substantially improved module properties, including: (1) few or zero misplaced genes; (2) increased counts of replicable clusters in alternate tissues (x3.1 on average); (3) improved enrichment of Gene Ontology terms (seen in 48/52 GCNs) (4) improved cell type enrichment signals (seen in 21/23 brain GCNs); and (5) more accurate partitions in simulated data according to a range of similarity indices. The results obtained from our investigations indicate that our k-means method, applied as an adjunct to standard WGCNA, results in better network partitions. These improved partitions enable more fruitful downstream analyses, as gene modules are more biologically meaningful. Identification of PEG-induced water stress responsive transcripts using co-expression network in Eucalyptus grandis. Ghosh Dasgupta, Modhumita; Dharanishanthi, Veeramuthu Ecophysiological studies in Eucalyptus have shown that water is the principal factor limiting stem growth. Effect of water deficit conditions on physiological and biochemical parameters has been extensively reported in Eucalyptus. The present study was conducted to identify major polyethylene glycol induced water stress responsive transcripts in Eucalyptus grandis using gene co-expression network. A customized array representing 3359 water stress responsive genes was designed to document their expression in leaves of E. grandis cuttings subjected to -0.225MPa of PEG treatment. The differentially expressed transcripts were documented and significantly co-expressed transcripts were used for construction of network. The co-expression network was constructed with 915 nodes and 3454 edges with degree ranging from 2 to 45. Ninety four GO categories and 117 functional pathways were identified in the network. MCODE analysis generated 27 modules and module 6 with 479 nodes and 1005 edges was identified as the biologically relevant network. The major water responsive transcripts represented in the module included dehydrin, osmotin, LEA protein, expansin, arabinogalactans, heat shock proteins, major facilitator proteins, ARM repeat proteins, raffinose synthase, tonoplast intrinsic protein and transcription factors like DREB2A, ARF9, AGL24, UNE12, WLIM1 and MYB66, MYB70, MYB 55, MYB 16 and MYB 103. The coordinated analysis of gene expression patterns and coexpression networks developed in this study identified an array of transcripts that may regulate PEG induced water stress responses in E. grandis. Copyright Â© 2017 Elsevier B.V. All rights reserved. Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex Hulsman, Marc; Lelieveldt, Boudewijn P. F.; de Ridder, Jeroen; Reinders, Marcel The three dimensional conformation of the genome in the cell nucleus influences important biological processes such as gene expression regulation. Recent studies have shown a strong correlation between chromatin interactions and gene co-expression. However, predicting gene co-expression from frequent long-range chromatin interactions remains challenging. We address this by characterizing the topology of the cortical chromatin interaction network using scale-aware topological measures. We demonstrate that based on these characterizations it is possible to accurately predict spatial co-expression between genes in the mouse cortex. Consistent with previous findings, we find that the chromatin interaction profile of a gene-pair is a good predictor of their spatial co-expression. However, the accuracy of the prediction can be substantially improved when chromatin interactions are described using scale-aware topological measures of the multi-resolution chromatin interaction network. We conclude that, for co-expression prediction, it is necessary to take into account different levels of chromatin interactions ranging from direct interaction between genes (i.e. small-scale) to chromatin compartment interactions (i.e. large-scale). PMID:25965262 Uncovering robust patterns of microRNA co-expression across cancers using Bayesian Relevance Networks. Parameswaran Ramachandran Full Text Available Co-expression networks have long been used as a tool for investigating the molecular circuitry governing biological systems. However, most algorithms for constructing co-expression networks were developed in the microarray era, before high-throughput sequencing-with its unique statistical properties-became the norm for expression measurement. Here we develop Bayesian Relevance Networks, an algorithm that uses Bayesian reasoning about expression levels to account for the differing levels of uncertainty in expression measurements between highly- and lowly-expressed entities, and between samples with different sequencing depths. It combines data from groups of samples (e.g., replicates to estimate group expression levels and confidence ranges. It then computes uncertainty-moderated estimates of cross-group correlations between entities, and uses permutation testing to assess their statistical significance. Using large scale miRNA data from The Cancer Genome Atlas, we show that our Bayesian update of the classical Relevance Networks algorithm provides improved reproducibility in co-expression estimates and lower false discovery rates in the resulting co-expression networks. Software is available at www.perkinslab.ca. Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI Wang, Weijing; Jiang, Wenjie; Hou, Lin BACKGROUND: The therapeutic management of obesity is challenging, hence further elucidating the underlying mechanisms of obesity development and identifying new diagnostic biomarkers and therapeutic targets are urgent and necessary. Here, we performed differential gene expression analysis......) were with a trend of up-regulation in twins with higher BMI when compared to their siblings. Categories of positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of NF-kappa B import into nucleus, and peroxidase activity were significantly enriched within GO database... Genetic Network Inference: From Co-Expression Clustering to Reverse Engineering Dhaeseleer, Patrik; Liang, Shoudan; Somogyi, Roland Advances in molecular biological, analytical, and computational technologies are enabling us to systematically investigate the complex molecular processes underlying biological systems. In particular, using high-throughput gene expression assays, we are able to measure the output of the gene regulatory network. We aim here to review datamining and modeling approaches for conceptualizing and unraveling the functional relationships implicit in these datasets. Clustering of co-expression profiles allows us to infer shared regulatory inputs and functional pathways. We discuss various aspects of clustering, ranging from distance measures to clustering algorithms and multiple-duster memberships. More advanced analysis aims to infer causal connections between genes directly, i.e., who is regulating whom and how. We discuss several approaches to the problem of reverse engineering of genetic networks, from discrete Boolean networks, to continuous linear and non-linear models. We conclude that the combination of predictive modeling with systematic experimental verification will be required to gain a deeper insight into living organisms, therapeutic targeting, and bioengineering. An extensive (co-expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana Provart Nicholas J Full Text Available Abstract Background Sequencing of the first plant genomes has revealed that cytochromes P450 have evolved to become the largest family of enzymes in secondary metabolism. The proportion of P450 enzymes with characterized biochemical function(s is however very small. If P450 diversification mirrors evolution of chemical diversity, this points to an unexpectedly poor understanding of plant metabolism. We assumed that extensive analysis of gene expression might guide towards the function of P450 enzymes, and highlight overlooked aspects of plant metabolism. Results We have created a comprehensive database, 'CYPedia', describing P450 gene expression in four data sets: organs and tissues, stress response, hormone response, and mutants of Arabidopsis thaliana, based on public Affymetrix ATH1 microarray expression data. P450 expression was then combined with the expression of 4,130 re-annotated genes, predicted to act in plant metabolism, for co-expression analyses. Based on the annotation of co-expressed genes from diverse pathway annotation databases, co-expressed pathways were identified. Predictions were validated for most P450s with known functions. As examples, co-expression results for P450s related to plastidial functions/photosynthesis, and to phenylpropanoid, triterpenoid and jasmonate metabolism are highlighted here. Conclusion The large scale hypothesis generation tools presented here provide leads to new pathways, unexpected functions, and regulatory networks for many P450s in plant metabolism. These can now be exploited by the community to validate the proposed functions experimentally using reverse genetics, biochemistry, and metabolic profiling. Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks. Recep Colak Full Text Available Computational prediction of functionally related groups of genes (functional modules from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented.We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB, by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples.We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze the modular organization of an organism based on prevalent and largely Colak, Recep; Moser, Flavia; Chu, Jeffrey Shih-Chieh; SchÃ¶nhuth, Alexander; Chen, Nansheng; Ester, Martin Computational prediction of functionally related groups of genes (functional modules) from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense) regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented. We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB), by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples. We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze the modular organization of an organism based on prevalent and largely available large FastGCN: a GPU accelerated tool for fast gene co-expression networks. Meimei Liang Full Text Available Gene co-expression networks comprise one type of valuable biological networks. Many methods and tools have been published to construct gene co-expression networks; however, most of these tools and methods are inconvenient and time consuming for large datasets. We have developed a user-friendly, accelerated and optimized tool for constructing gene co-expression networks that can fully harness the parallel nature of GPU (Graphic Processing Unit architectures. Genetic entropies were exploited to filter out genes with no or small expression changes in the raw data preprocessing step. Pearson correlation coefficients were then calculated. After that, we normalized these coefficients and employed the False Discovery Rate to control the multiple tests. At last, modules identification was conducted to construct the co-expression networks. All of these calculations were implemented on a GPU. We also compressed the coefficient matrix to save space. We compared the performance of the GPU implementation with those of multi-core CPU implementations with 16 CPU threads, single-thread C/C++ implementation and single-thread R implementation. Our results show that GPU implementation largely outperforms single-thread C/C++ implementation and single-thread R implementation, and GPU implementation outperforms multi-core CPU implementation when the number of genes increases. With the test dataset containing 16,000 genes and 590 individuals, we can achieve greater than 63 times the speed using a GPU implementation compared with a single-thread R implementation when 50 percent of genes were filtered out and about 80 times the speed when no genes were filtered out. Construction and comparison of gene co-expression networks shows complex plant immune responses Luis Guillermo Leal Full Text Available Gene co-expression networks (GCNs are graphic representations that depict the coordinated transcription of genes in response to certain stimuli. GCNs provide functional annotations of genes whose function is unknown and are further used in studies of translational functional genomics among species. In this work, a methodology for the reconstruction and comparison of GCNs is presented. This approach was applied using gene expression data that were obtained from immunity experiments in Arabidopsis thaliana, rice, soybean, tomato and cassava. After the evaluation of diverse similarity metrics for the GCN reconstruction, we recommended the mutual information coefficient measurement and a clustering coefficient-based method for similarity threshold selection. To compare GCNs, we proposed a multivariate approach based on the Principal Component Analysis (PCA. Branches of plant immunity that were exemplified by each experiment were analyzed in conjunction with the PCA results, suggesting both the robustness and the dynamic nature of the cellular responses. The dynamic of molecular plant responses produced networks with different characteristics that are differentiable using our methodology. The comparison of GCNs from plant pathosystems, showed that in response to similar pathogens plants could activate conserved signaling pathways. The results confirmed that the closeness of GCNs projected on the principal component space is an indicative of similarity among GCNs. This also can be used to understand global patterns of events triggered during plant immune responses. MPIGeneNet: Parallel Calculation of Gene Co-Expression Networks on Multicore Clusters. Gonzalez-Dominguez, Jorge; Martin, Maria J In this work we present MPIGeneNet, a parallel tool that applies Pearson's correlation and Random Matrix Theory to construct gene co-expression networks. It is based on the state-of-the-art sequential tool RMTGeneNet, which provides networks with high robustness and sensitivity at the expenses of relatively long runtimes for large scale input datasets. MPIGeneNet returns the same results as RMTGeneNet but improves the memory management, reduces the I/O cost, and accelerates the two most computationally demanding steps of co-expression network construction by exploiting the compute capabilities of common multicore CPU clusters. Our performance evaluation on two different systems using three typical input datasets shows that MPIGeneNet is significantly faster than RMTGeneNet. As an example, our tool is up to 175.41 times faster on a cluster with eight nodes, each one containing two 12-core Intel Haswell processors. Source code of MPIGeneNet, as well as a reference manual, are available at https://sourceforge.net/projects/mpigenenet/. A contribution to the study of plant development evolution based on gene co-expression networks Francisco J. Romero-Campero Full Text Available Phototrophic eukaryotes are among the most successful organisms on Earth due to their unparalleled efficiency at capturing light energy and fixing carbon dioxide to produce organic molecules. A conserved and efficient network of light-dependent regulatory modules could be at the bases of this success. This regulatory system conferred early advantages to phototrophic eukaryotes that allowed for specialization, complex developmental processes and modern plant characteristics. We have studied light-dependent gene regulatory modules from algae to plants employing integrative-omics approaches based on gene co-expression networks. Our study reveals some remarkably conserved ways in which eukaryotic phototrophs deal with day length and light signaling. Here we describe how a family of Arabidopsis transcription factors involved in photoperiod response has evolved from a single algal gene according to the innovation, amplification and divergence theory of gene evolution by duplication. These modifications of the gene co-expression networks from the ancient unicellular green algae Chlamydomonas reinhardtii to the modern brassica Arabidopsis thaliana may hint on the evolution and specialization of plants and other organisms. Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks. Nicholas J Hudson Full Text Available BACKGROUND: Despite modern technologies and novel computational approaches, decoding causal transcriptional regulation remains challenging. This is particularly true for less well studied organisms and when only gene expression data is available. In muscle a small number of well characterised transcription factors are proposed to regulate development. Therefore, muscle appears to be a tractable system for proposing new computational approaches. METHODOLOGY/PRINCIPAL FINDINGS: Here we report a simple algorithm that asks "which transcriptional regulator has the highest average absolute co-expression correlation to the genes in a co-expression module?" It correctly infers a number of known causal regulators of fundamental biological processes, including cell cycle activity (E2F1, glycolysis (HLF, mitochondrial transcription (TFB2M, adipogenesis (PIAS1, neuronal development (TLX3, immune function (IRF1 and vasculogenesis (SOX17, within a skeletal muscle context. However, none of the canonical pro-myogenic transcription factors (MYOD1, MYOG, MYF5, MYF6 and MEF2C were linked to muscle structural gene expression modules. Co-expression values were computed using developing bovine muscle from 60 days post conception (early foetal to 30 months post natal (adulthood for two breeds of cattle, in addition to a nutritional comparison with a third breed. A number of transcriptional landscapes were constructed and integrated into an always correlated landscape. One notable feature was a 'metabolic axis' formed from glycolysis genes at one end, nuclear-encoded mitochondrial protein genes at the other, and centrally tethered by mitochondrially-encoded mitochondrial protein genes. CONCLUSIONS/SIGNIFICANCE: The new module-to-regulator algorithm complements our recently described Regulatory Impact Factor analysis. Together with a simple examination of a co-expression module's contents, these three gene expression approaches are starting to illuminate the in vivo Gene co-expression networks shed light into diseases of brain iron accumulation. Bettencourt, ConceiÃ§Ã£o; Forabosco, Paola; Wiethoff, Sarah; Heidari, Moones; Johnstone, Daniel M; BotÃa, Juan A; Collingwood, Joanna F; Hardy, John; Milward, Elizabeth A; Ryten, Mina; Houlden, Henry Aberrant brain iron deposition is observed in both common and rare neurodegenerative disorders, including those categorized as Neurodegeneration with Brain Iron Accumulation (NBIA), which are characterized by focal iron accumulation in the basal ganglia. Two NBIA genes are directly involved in iron metabolism, but whether other NBIA-related genes also regulate iron homeostasis in the human brain, and whether aberrant iron deposition contributes to neurodegenerative processes remains largely unknown. This study aims to expand our understanding of these iron overload diseases and identify relationships between known NBIA genes and their main interacting partners by using a systems biology approach. We used whole-transcriptome gene expression data from human brain samples originating from 101 neuropathologically normal individuals (10 brain regions) to generate weighted gene co-expression networks and cluster the 10 known NBIA genes in an unsupervised manner. We investigated NBIA-enriched networks for relevant cell types and pathways, and whether they are disrupted by iron loading in NBIA diseased tissue and in an in vivo mouse model. We identified two basal ganglia gene co-expression modules significantly enriched for NBIA genes, which resemble neuronal and oligodendrocytic signatures. These NBIA gene networks are enriched for iron-related genes, and implicate synapse and lipid metabolism related pathways. Our data also indicates that these networks are disrupted by excessive brain iron loading. We identified multiple cell types in the origin of NBIA disorders. We also found unforeseen links between NBIA networks and iron-related processes, and demonstrate convergent pathways connecting NBIAs and phenotypically overlapping diseases. Our results are of further relevance for these diseases by providing candidates for new causative genes and possible points for therapeutic intervention. Copyright Â© 2015 The Authors. Published by Elsevier Inc. All rights reserved. Co-expression networks reveal the tissue-specific regulation of transcription and splicing. Saha, Ashis; Kim, Yungil; Gewirtz, Ariel D H; Jo, Brian; Gao, Chuan; McDowell, Ian C; Engelhardt, Barbara E; Battle, Alexis Gene co-expression networks capture biologically important patterns in gene expression data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of genetic variants. Most network analyses to date have been limited to assessing correlation between total gene expression levels in a single tissue or small sets of tissues. Here, we built networks that additionally capture the regulation of relative isoform abundance and splicing, along with tissue-specific connections unique to each of a diverse set of tissues. We used the Genotype-Tissue Expression (GTEx) project v6 RNA sequencing data across 50 tissues and 449 individuals. First, we developed a framework called Transcriptome-Wide Networks (TWNs) for combining total expression and relative isoform levels into a single sparse network, capturing the interplay between the regulation of splicing and transcription. We built TWNs for 16 tissues and found that hubs in these networks were strongly enriched for splicing and RNA binding genes, demonstrating their utility in unraveling regulation of splicing in the human transcriptome. Next, we used a Bayesian biclustering model that identifies network edges unique to a single tissue to reconstruct Tissue-Specific Networks (TSNs) for 26 distinct tissues and 10 groups of related tissues. Finally, we found genetic variants associated with pairs of adjacent nodes in our networks, supporting the estimated network structures and identifying 20 genetic variants with distant regulatory impact on transcription and splicing. Our networks provide an improved understanding of the complex relationships of the human transcriptome across tissues. Â© 2017 Saha et al.; Published by Cold Spring Harbor Laboratory Press. From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data. Vella, Danila; Zoppis, Italo; Mauri, Giancarlo; Mauri, Pierluigi; Di Silvestre, Dario The reductionist approach of dissecting biological systems into their constituents has been successful in the first stage of the molecular biology to elucidate the chemical basis of several biological processes. This knowledge helped biologists to understand the complexity of the biological systems evidencing that most biological functions do not arise from individual molecules; thus, realizing that the emergent properties of the biological systems cannot be explained or be predicted by investigating individual molecules without taking into consideration their relations. Thanks to the improvement of the current -omics technologies and the increasing understanding of the molecular relationships, even more studies are evaluating the biological systems through approaches based on graph theory. Genomic and proteomic data are often combined with protein-protein interaction (PPI) networks whose structure is routinely analyzed by algorithms and tools to characterize hubs/bottlenecks and topological, functional, and disease modules. On the other hand, co-expression networks represent a complementary procedure that give the opportunity to evaluate at system level including organisms that lack information on PPIs. Based on these premises, we introduce the reader to the PPI and to the co-expression networks, including aspects of reconstruction and analysis. In particular, the new idea to evaluate large-scale proteomic data by means of co-expression networks will be discussed presenting some examples of application. Their use to infer biological knowledge will be shown, and a special attention will be devoted to the topological and module analysis. Pathway enrichment and co-expression cluster analysis - FANTOM5 \| LSDB Archive [Life Science Database Archive metadata Lifescience Database Archive (English) Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data List Contact us FANTOM...lusters File URL: ftp://ftp.biosciencedbc.jp/archive/fantom5/datafiles/phase1.3/extra/Co-expression_clusters...ite Policy \| Contact Us Pathway enrichment and co-expression cluster analysis - FANTOM5 \| LSDB Archive ... A co-expression gene network associated with developmental regulation of apple fruit acidity. Bai, Yang; Dougherty, Laura; Cheng, Lailiang; Xu, Kenong Apple fruit acidity, which affects the fruit's overall taste and flavor to a large extent, is primarily determined by the concentration of malic acid. Previous studies demonstrated that the major QTL malic acid (Ma) on chromosome 16 is largely responsible for fruit acidity variations in apple. Recent advances suggested that a natural mutation that gives rise to a premature stop codon in one of the two aluminum-activated malate transporter (ALMT)-like genes (called Ma1) is the genetic causal element underlying Ma. However, the natural mutation does not explain the developmental changes of fruit malate levels in a given genotype. Using RNA-seq data from the fruit of 'Golden Delicious' taken at 14 developmental stages from 1 week after full-bloom (WAF01) to harvest (WAF20), we characterized their transcriptomes in groups of high (12.2 Â± 1.6 mg/g fw, WAF03-WAF08), mid (7.4 Â± 0.5 mg/g fw, WAF01-WAF02 and WAF10-WAF14) and low (5.4 Â± 0.4 mg/g fw, WAF16-WAF20) malate concentrations. Detailed analyses showed that a set of 3,066 genes (including Ma1) were expressed not only differentially (P FDR < 0.05) between the high and low malate groups (or between the early and late developmental stages) but also in significant (P < 0.05) correlation with malate concentrations. The 3,066 genes fell in 648 MapMan (sub-) bins or functional classes, and 19 of them were significantly (P FDR < 0.05) co-enriched or co-suppressed in a malate dependent manner. Network inferring using the 363 genes encompassed in the 19 (sub-) bins, identified a major co-expression network of 239 genes. Since the 239 genes were also differentially expressed between the early (WAF03-WAF08) and late (WAF16-WAF20) developmental stages, the major network was considered to be associated with developmental regulation of apple fruit acidity in 'Golden Delicious'. Gene co-expression networks and profiles reveal potential biomarkers of boar taint in pigs Drag, Markus; SkinkytÃ©-JuskienÃ©, R.; Do, Duy Ngoc synthesis. In testis, >80 DE genes were functionally classified by the PANTHER tool to â€œGonadotropin releasing hormone receptorâ€� and â€œWnt signalingâ€� pathways which play a role in reproductive maturation and proliferation of spermatogonia, respectively. WGCNA was used to build co-expression modules... Global similarity and local divergence in human and mouse gene co-expression networks Koonin Eugene V Full Text Available Abstract Background A genome-wide comparative analysis of human and mouse gene expression patterns was performed in order to evaluate the evolutionary divergence of mammalian gene expression. Tissue-specific expression profiles were analyzed for 9,105 human-mouse orthologous gene pairs across 28 tissues. Expression profiles were resolved into species-specific coexpression networks, and the topological properties of the networks were compared between species. Results At the global level, the topological properties of the human and mouse gene coexpression networks are, essentially, identical. For instance, both networks have topologies with small-world and scale-free properties as well as closely similar average node degrees, clustering coefficients, and path lengths. However, the human and mouse coexpression networks are highly divergent at the local level: only a small fraction ( Conclusion The dissonance between global versus local network divergence suggests that the interspecies similarity of the global network properties is of limited biological significance, at best, and that the biologically relevant aspects of the architectures of gene coexpression are specific and particular, rather than universal. Nevertheless, there is substantial evolutionary conservation of the local network structure which is compatible with the notion that gene coexpression networks are subject to purifying selection. A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways Musungu, Bryan M.; Bhatnagar, Deepak; Brown, Robert L.; Payne, Gary A.; OBrian, Greg; Fakhoury, Ahmad M.; Geisler, Matt A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). For the pathogen A. flav... Step-by-Step Construction of Gene Co-expression Networks from High-Throughput Arabidopsis RNA Sequencing Data. Contreras-LÃ³pez, Orlando; Moyano, TomÃ¡s C; Soto, Daniela C; GutiÃ©rrez, Rodrigo A The rapid increase in the availability of transcriptomics data generated by RNA sequencing represents both a challenge and an opportunity for biologists without bioinformatics training. The challenge is handling, integrating, and interpreting these data sets. The opportunity is to use this information to generate testable hypothesis to understand molecular mechanisms controlling gene expression and biological processes (Fig. 1). A successful strategy to generate tractable hypotheses from transcriptomics data has been to build undirected network graphs based on patterns of gene co-expression. Many examples of new hypothesis derived from network analyses can be found in the literature, spanning different organisms including plants and specific fields such as root developmental biology.In order to make the process of constructing a gene co-expression network more accessible to biologists, here we provide step-by-step instructions using published RNA-seq experimental data obtained from a public database. Similar strategies have been used in previous studies to advance root developmental biology. This guide includes basic instructions for the operation of widely used open source platforms such as Bio-Linux, R, and Cytoscape. Even though the data we used in this example was obtained from Arabidopsis thaliana, the workflow developed in this guide can be easily adapted to work with RNA-seq data from any organism. Dynamic sporulation gene co-expression networks for Bacillus subtilis 168 and the food-borne isolate Bacillus amyloliquefaciens: a transcriptomic model. Omony, Jimmy; de Jong, Anne; Krawczyk, Antonina O; Eijlander, Robyn T; Kuipers, Oscar P Sporulation is a survival strategy, adapted by bacterial cells in response to harsh environmental adversities. The adaptation potential differs between strains and the variations may arise from differences in gene regulation. Gene networks are a valuable way of studying such regulation processes and establishing associations between genes. We reconstructed and compared sporulation gene co-expression networks (GCNs) of the model laboratory strain Bacillus subtilis 168 and the food-borne industrial isolate Bacillus amyloliquefaciens. Transcriptome data obtained from samples of six stages during the sporulation process were used for network inference. Subsequently, a gene set enrichment analysis was performed to compare the reconstructed GCNs of B. subtilis 168 and B. amyloliquefaciens with respect to biological functions, which showed the enriched modules with coherent functional groups associated with sporulation. On basis of the GCNs and time-evolution of differentially expressed genes, we could identify novel candidate genes strongly associated with sporulation in B. subtilis 168 and B. amyloliquefaciens. The GCNs offer a framework for exploring transcription factors, their targets, and co-expressed genes during sporulation. Furthermore, the methodology described here can conveniently be applied to other species or biological processes. GeneCAT--novel webtools that combine BLAST and co-expression analyses Mutwil, Marek; Obro, Jens; Willats, William G T The gene co-expression analysis toolbox (GeneCAT) introduces several novel microarray data analyzing tools. First, the multigene co-expression analysis, combined with co-expressed gene networks, provides a more powerful data mining technique than standard, single-gene co-expression analysis. Second...... orthologs in the plant model organisms Arabidopsis thaliana and Hordeum vulgare (Barley). GeneCAT is equipped with expression data for the model plant A. thaliana, and first to introduce co-expression mining tools for the monocot Barley. GeneCAT is available at http://genecat.mpg.de.... Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular networks R. Colak; F. Moser; J. Shu; A. SchÃ¶nhuth (Alexander); N. Chen; M. Ester htmlabstractBackground Computational prediction of functionally related groups of genes (functional modules) from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not Uncovering the liverâ€™s role in immunity through RNA co-expression networks Harrall, K. K.; Kechris, K. J.; Tabakoff, B.; Hoffman, P.L.; Hines, L. M.; Tsukamoto, H.; Pravenec, Michal; Printz, M.; Saba, L. M. RoÄ�. 27, 9-10 (2016), s. 469-484 ISSN 0938-8990 R&D Projects: GA ÄŒR(CZ) GAP301/12/0696 Institutional support: RVO:67985823 Keywords : RNA coexpression networks liver * immunity * rat * recombinant inbred strains Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.509, year: 2016 A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). For the pathogen A. flavus, a link between aflatoxin production and vesicular transport was identified within the network. There was significant interspecies correlation of expression between Z. mays and A. flavus for a subset of 104 Z. mays, and 1942 A. flavus genes. This resulted in an interspecies subnetwork enriched in multiple Z. mays genes involved in the production of ROS. In addition to the ROS from Z. mays, there was enrichment in the vesicular transport pathways and the aflatoxin pathway for A. flavus. Included in these genes, a key aflatoxin cluster regulator, AflS, was found to be co-regulated with multiple Z. mays ROS producing genes within the network, suggesting AflS may be monitoring host ROS levels. The entire GEN for both host and pathogen, and the subset of interspecies correlations, is presented as a tool for hypothesis generation and discovery for events in the early stages of fungal infection of Z. mays by A. flavus. PMID:27917194 A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways. Musungu, Bryan M; Bhatnagar, Deepak; Brown, Robert L; Payne, Gary A; OBrian, Greg; Fakhoury, Ahmad M; Geisler, Matt A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). For the pathogen A. flavus , a link between aflatoxin production and vesicular transport was identified within the network. There was significant interspecies correlation of expression between Z. mays and A. flavus for a subset of 104 Z. mays , and 1942 A. flavus genes. This resulted in an interspecies subnetwork enriched in multiple Z. mays genes involved in the production of ROS. In addition to the ROS from Z. mays , there was enrichment in the vesicular transport pathways and the aflatoxin pathway for A. flavus . Included in these genes, a key aflatoxin cluster regulator, AflS, was found to be co-regulated with multiple Z. mays ROS producing genes within the network, suggesting AflS may be monitoring host ROS levels. The entire GEN for both host and pathogen, and the subset of interspecies correlations, is presented as a tool for hypothesis generation and discovery for events in the early stages of fungal infection of Z. mays by A. flavus . VSNL1 Co-expression networks in aging include calcium signaling, synaptic plasticity, and Alzheimerâ€™s disease pathways C W Lin Full Text Available The Visinin-like 1 (VSNL1 gene encodes Visinin-like protein 1, a peripheral biomarker for Alzheimer disease (AD. Little is known, however, about normal VSNL1 expression in brain and the biologic networks in which it participates. Frontal cortex gray matter from 209 subjects without neurodegenerative or psychiatric illness, ranging in age from 16â€“91, were processed on Affymetrix GeneChip 1.1 ST and Human SNP Array 6.0. VSNL1 expression was unaffected by age and sex, and not significantly associated with SNPs in cis or trans. VSNL1 was significantly co-expressed with genes in pathways for Calcium Signaling, AD, Long Term Potentiation, Long Term Depression, and Trafficking of AMPA Receptors. The association with AD was driven, in part, by correlation with amyloid precursor protein (APP expression. These findings provide an unbiased link between VSNL1 and molecular mechanisms of AD, including pathways implicated in synaptic pathology in AD. Whether APP may drive increased VSNL1 expression, VSNL1 drives increased APP expression, or both are downstream of common pathogenic regulators will need to be evaluated in model systems. Comprehensive analysis of differential co-expression patterns reveal transcriptional dysregulation mechanism and identify novel prognostic lncRNAs in esophageal squamous cell carcinoma Li Z Full Text Available Zhen Li,1 Qianlan Yao,1 Songjian Zhao,1 Yin Wang,2,3 Yixue Li,1,4 Zhen Wang4 1School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 2Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, 3Collaborative Innovation Center for Genetics and Development, Fudan University, 4Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, Peopleâ€™s Republic of China Abstract: Esophageal squamous cell carcinoma (ESCC is one of the most common malignancies worldwide and occurs at a relatively high frequency in Peopleâ€™s Republic of China. However, the molecular mechanism underlying ESCC is still unclear. In this study, the mRNA and long non-coding RNA (lncRNA expression profiles of ESCC were downloaded from the Gene Expression Omnibus database, and then differential co-expression analysis was used to reveal the altered co-expression relationship of gene pairs in ESCC tumors. A total of 3,709 mRNAs and 923 lncRNAs were differentially co-expressed between normal and tumor tissues, and we found that most of the gene pairs lost associations in the tumor tissues. The differential regulatory networking approach deciphered that transcriptional dysregulation was ubiquitous in ESCC, and most of the differentially regulated links were modulated by 37 TFs. Our study also found that two novel lncRNAs (ADAMTS9-AS1 and AP000696.2 might be essential in the development of ectoderm and epithelial cells, which could significantly stratify ESCC patients into high-risk and low-risk groups, and were much better than traditional clinical tumor markers. Further inspection of two risk groups showed that the changes in TF-target regulation in the high-risk patients were significantly higher than those in the low-risk patients. In addition, four signal transduction-related DCmRNAs (ERBB3, ENSA, KCNK7, MFSD5 Gene co-expression analysis identifies gene clusters associated with isotropic and polarized growth in Aspergillus fumigatus conidia. Baltussen, Tim J H; Coolen, Jordy P M; Zoll, Jan; Verweij, Paul E; Melchers, Willem J G Aspergillus fumigatus is a saprophytic fungus that extensively produces conidia. These microscopic asexually reproductive structures are small enough to reach the lungs. Germination of conidia followed by hyphal growth inside human lungs is a key step in the establishment of infection in immunocompromised patients. RNA-Seq was used to analyze the transcriptome of dormant and germinating A. fumigatus conidia. Construction of a gene co-expression network revealed four gene clusters (modules) correlated with a growth phase (dormant, isotropic growth, polarized growth). Transcripts levels of genes encoding for secondary metabolites were high in dormant conidia. During isotropic growth, transcript levels of genes involved in cell wall modifications increased. Two modules encoding for growth and cell cycle/DNA processing were associated with polarized growth. In addition, the co-expression network was used to identify highly connected intermodular hub genes. These genes may have a pivotal role in the respective module and could therefore be compelling therapeutic targets. Generally, cell wall remodeling is an important process during isotropic and polarized growth, characterized by an increase of transcripts coding for hyphal growth and cell cycle/DNA processing when polarized growth is initiated. Copyright Â© 2018 The Authors. Published by Elsevier Inc. All rights reserved. Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging. Pabba, Mohan; Scifo, Enzo; Kapadia, Fenika; Nikolova, Yuliya S; Ma, Tianzhou; Mechawar, Naguib; Tseng, George C; Sibille, Etienne The orbitofrontal cortex (OFC) is vulnerable to normal and pathologic aging. Currently, layer resolution large-scale proteomic studies describing "normal" age-related alterations at OFC are not available. Here, we performed a large-scale exploratory high-throughput mass spectrometry-based protein analysis on OFC layer 2/3 from 15 "young" (15-43Â years) and 18 "old" (62-88Â years) human male subjects. We detected 4193 proteins and identified 127 differentially expressed (DE) proteins (p-value â‰¤0.05; effect size >20%), including 65 up- and 62 downregulated proteins (e.g., GFAP, CALB1). Using a previously described categorization of biological aging based on somatic tissues, that is, peripheral "hallmarks of aging," and considering overlap in protein function, we show the highest representation of altered cell-cell communication (54%), deregulated nutrient sensing (39%), and loss of proteostasis (35%) in the set of OFC layer 2/3 DE proteins. DE proteins also showed a significant association with several neurologic disorders; for example, Alzheimer's disease and schizophrenia. Notably, despite age-related changes in individual protein levels, protein co-expression modules were remarkably conserved across age groups, suggesting robust functional homeostasis. Collectively, these results provide biological insight into aging and associated homeostatic mechanisms that maintain normal brain function with advancing age. Copyright Â© 2017 Elsevier Inc. All rights reserved. The Arabidopsis co-expression tool (act): a WWW-based tool and database for microarray-based gene expression analysis Jen, C. H.; Manfield, I. W.; Michalopoulos, D. W. be examined using the novel clique finder tool to determine the sets of genes most likely to be regulated in a similar manner. In combination, these tools offer three levels of analysis: creation of correlation lists of co-expressed genes, refinement of these lists using two-dimensional scatter plots......We present a new WWW-based tool for plant gene analysis, the Arabidopsis Co-Expression Tool (act) , based on a large Arabidopsis thaliana microarray data set obtained from the Nottingham Arabidopsis Stock Centre. The co-expression analysis tool allows users to identify genes whose expression... Divergent and convergent modes of interaction between wheat and Puccinia graminis f. sp. tritici isolates revealed by the comparative gene co-expression network and genome analyses. Rutter, William B; Salcedo, Andres; Akhunova, Alina; He, Fei; Wang, Shichen; Liang, Hanquan; Bowden, Robert L; Akhunov, Eduard Two opposing evolutionary constraints exert pressure on plant pathogens: one to diversify virulence factors in order to evade plant defenses, and the other to retain virulence factors critical for maintaining a compatible interaction with the plant host. To better understand how the diversified arsenals of fungal genes promote interaction with the same compatible wheat line, we performed a comparative genomic analysis of two North American isolates of Puccinia graminis f. sp. tritici (Pgt). The patterns of inter-isolate divergence in the secreted candidate effector genes were compared with the levels of conservation and divergence of plant-pathogen gene co-expression networks (GCN) developed for each isolate. Comprative genomic analyses revealed substantial level of interisolate divergence in effector gene complement and sequence divergence. Gene Ontology (GO) analyses of the conserved and unique parts of the isolate-specific GCNs identified a number of conserved host pathways targeted by both isolates. Interestingly, the degree of inter-isolate sub-network conservation varied widely for the different host pathways and was positively associated with the proportion of conserved effector candidates associated with each sub-network. While different Pgt isolates tended to exploit similar wheat pathways for infection, the mode of plant-pathogen interaction varied for different pathways with some pathways being associated with the conserved set of effectors and others being linked with the diverged or isolate-specific effectors. Our data suggest that at the intra-species level pathogen populations likely maintain divergent sets of effectors capable of targeting the same plant host pathways. This functional redundancy may play an important role in the dynamic of the "arms-race" between host and pathogen serving as the basis for diverse virulence strategies and creating conditions where mutations in certain effector groups will not have a major effect on the pathogen Disease gene characterization through large-scale co-expression analysis. Allen Day Full Text Available In the post genome era, a major goal of biology is the identification of specific roles for individual genes. We report a new genomic tool for gene characterization, the UCLA Gene Expression Tool (UGET.Celsius, the largest co-normalized microarray dataset of Affymetrix based gene expression, was used to calculate the correlation between all possible gene pairs on all platforms, and generate stored indexes in a web searchable format. The size of Celsius makes UGET a powerful gene characterization tool. Using a small seed list of known cartilage-selective genes, UGET extended the list of known genes by identifying 32 new highly cartilage-selective genes. Of these, 7 of 10 tested were validated by qPCR including the novel cartilage-specific genes SDK2 and FLJ41170. In addition, we retrospectively tested UGET and other gene expression based prioritization tools to identify disease-causing genes within known linkage intervals. We first demonstrated this utility with UGET using genetically heterogeneous disorders such as Joubert syndrome, microcephaly, neuropsychiatric disorders and type 2 limb girdle muscular dystrophy (LGMD2 and then compared UGET to other gene expression based prioritization programs which use small but discrete and well annotated datasets. Finally, we observed a significantly higher gene correlation shared between genes in disease networks associated with similar complex or Mendelian disorders.UGET is an invaluable resource for a geneticist that permits the rapid inclusion of expression criteria from one to hundreds of genes in genomic intervals linked to disease. By using thousands of arrays UGET annotates and prioritizes genes better than other tools especially with rare tissue disorders or complex multi-tissue biological processes. This information can be critical in prioritization of candidate genes for sequence analysis. Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. Jia, Zhilong; Liu, Ying; Guan, Naiyang; Bo, Xiaochen; Luo, Zhigang; Barnes, Michael R Drug repositioning, finding new indications for existing drugs, has gained much recent attention as a potentially efficient and economical strategy for accelerating new therapies into the clinic. Although improvement in the sensitivity of computational drug repositioning methods has identified numerous credible repositioning opportunities, few have been progressed. Arguably the "black box" nature of drug action in a new indication is one of the main blocks to progression, highlighting the need for methods that inform on the broader target mechanism in the disease context. We demonstrate that the analysis of co-expressed genes may be a critical first step towards illumination of both disease pathology and mode of drug action. We achieve this using a novel framework, co-expressed gene-set enrichment analysis (cogena) for co-expression analysis of gene expression signatures and gene set enrichment analysis of co-expressed genes. The cogena framework enables simultaneous, pathway driven, disease and drug repositioning analysis. Cogena can be used to illuminate coordinated changes within disease transcriptomes and identify drugs acting mechanistically within this framework. We illustrate this using a psoriatic skin transcriptome, as an exemplar, and recover two widely used Psoriasis drugs (Methotrexate and Ciclosporin) with distinct modes of action. Cogena out-performs the results of Connectivity Map and NFFinder webservers in similar disease transcriptome analyses. Furthermore, we investigated the literature support for the other top-ranked compounds to treat psoriasis and showed how the outputs of cogena analysis can contribute new insight to support the progression of drugs into the clinic. We have made cogena freely available within Bioconductor or https://github.com/zhilongjia/cogena . In conclusion, by targeting co-expressed genes within disease transcriptomes, cogena offers novel biological insight, which can be effectively harnessed for drug discovery and The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks Kim Clarke Full Text Available Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance. Our work demonstrates the validity of a data-driven approach to understanding muscle homeostasis. Additional file 5: Figure S1. of Uncovering co-expression gene network modules regulating fruit acidity in diverse apples Analysis of modules Black, Brown, Blue and Yellow. (A) Module eigengene values across the 29 samples, including 17 in Ma_ on left and 12 in mama on right. Samples are represented by the combination of a letter (abbreviated cultivar name) and a number (replicate) (see legends in Fig.Ã‚Â 1, 4 for keys). (B) Correlation between module membership (MM) and gene significance (GS) for malate. (PPTX 75Ã‚Â kb) A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. Simone de Jong Full Text Available Despite large-scale genome-wide association studies (GWAS, the underlying genes for schizophrenia are largely unknown. Additional approaches are therefore required to identify the genetic background of this disorder. Here we report findings from a large gene expression study in peripheral blood of schizophrenia patients and controls. We applied a systems biology approach to genome-wide expression data from whole blood of 92 medicated and 29 antipsychotic-free schizophrenia patients and 118 healthy controls. We show that gene expression profiling in whole blood can identify twelve large gene co-expression modules associated with schizophrenia. Several of these disease related modules are likely to reflect expression changes due to antipsychotic medication. However, two of the disease modules could be replicated in an independent second data set involving antipsychotic-free patients and controls. One of these robustly defined disease modules is significantly enriched with brain-expressed genes and with genetic variants that were implicated in a GWAS study, which could imply a causal role in schizophrenia etiology. The most highly connected intramodular hub gene in this module (ABCF1, is located in, and regulated by the major histocompatibility (MHC complex, which is intriguing in light of the fact that common allelic variants from the MHC region have been implicated in schizophrenia. This suggests that the MHC increases schizophrenia susceptibility via altered gene expression of regulatory genes in this network. Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs. Ballester, Maria; Ramayo-Caldas, Yuliaxis; Revilla, Manuel; Corominas, Jordi; CastellÃ³, Anna; EstellÃ©, Jordi; FernÃ¡ndez, Ana I; Folch, Josep M In the present study, liver co-expression networks and expression Genome Wide Association Study (eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional regulatory mechanisms of meat quality traits in pigs. With this purpose, the liver mRNA expression of 44 candidates genes related with lipid metabolism was analysed in 111 Iberian x Landrace backcross animals. The eGWAS identified 92 eSNPs located in seven chromosomal regions and associated with eight genes: CROT, CYP2U1, DGAT1, EGF, FABP1, FABP5, PLA2G12A, and PPARA. Remarkably, cis-eSNPs associated with FABP1 gene expression which may be determining the C18:2(n-6)/C18:3(n-3) ratio in backfat through the multiple interaction of DNA variants and genes were identified. Furthermore, a hotspot on SSC8 associated with the gene expression of eight genes was identified and the TBCK gene was pointed out as candidate gene regulating it. Our results also suggested that the PI3K-Akt-mTOR pathway plays an important role in the control of the analysed genes highlighting nuclear receptors as the NR3C1 or PPARA. Finally, sex-dimorphism associated with hepatic lipid metabolism was identified with over-representation of female-biased genes. These results increase our knowledge of the genetic architecture underlying fat composition traits. Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries. Miao, Xiangyang; Luo, Qingmiao; Zhao, Huijing; Qin, Xiaoyu Small Tail Han sheep, including the FecB B FecB B (Han BB) and FecB + FecB + (Han++) genotypes, and Dorset sheep exhibit different fecundities. To identify novel long non-coding RNAs (lncRNAs) associated with sheep fecundity to better understand their molecular mechanisms, a genome-wide analysis of mRNAs and lncRNAs from Han BB, Han++ and Dorset sheep was performed. After the identification of differentially expressed mRNAs and lncRNAs, 16 significant modules were explored by using weighted gene coexpression network analysis (WGCNA) followed by functional enrichment analysis of the genes and lncRNAs in significant modules. Among these selected modules, the yellow and brown modules were significantly related to sheep fecundity. lncRNAs (e.g., NR0B1, XLOC_041882, and MYH15) in the yellow module were mainly involved in the TGF-Î² signalling pathway, and NYAP1 and BCORL1 were significantly associated with the oxytocin signalling pathway, which regulates several genes in the coexpression network of the brown module. Overall, we identified several gene modules associated with sheep fecundity, as well as networks consisting of hub genes and lncRNAs that may contribute to sheep prolificacy by regulating the target mRNAs related to the TGF-Î² and oxytocin signalling pathways. This study provides an alternative strategy for the identification of potential candidate regulatory lncRNAs. Pathways of Lipid Metabolism in Marine Algae, Co-Expression Network, Bottlenecks and Candidate Genes for Enhanced Production of EPA and DHA in Species of Chromista Alice MÃ¼hlroth Full Text Available The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs for human health has received more focus the last decades, and the global consumption of n-3 LC-PUFA has increased. Seafood, the natural n-3 LC-PUFA source, is harvested beyond a sustainable capacity, and it is therefore imperative to develop alternative n-3 LC-PUFA sources for both eicosapentaenoic acid (EPA, 20:5n-3 and docosahexaenoic acid (DHA, 22:6n-3. Genera of algae such as Nannochloropsis, Schizochytrium, Isochrysis and Phaedactylum within the kingdom Chromista have received attention due to their ability to produce n-3 LC-PUFAs. Knowledge of LC-PUFA synthesis and its regulation in algae at the molecular level is fragmentary and represents a bottleneck for attempts to enhance the n-3 LC-PUFA levels for industrial production. In the present review, Phaeodactylum tricornutum has been used to exemplify the synthesis and compartmentalization of n-3 LC-PUFAs. Based on recent transcriptome data a co-expression network of 106 genes involved in lipid metabolism has been created. Together with recent molecular biological and metabolic studies, a model pathway for n-3 LC-PUFA synthesis in P. tricornutum has been proposed, and is compared to industrialized species of Chromista. Limitations of the n-3 LC-PUFA synthesis by enzymes such as thioesterases, elongases, acyl-CoA synthetases and acyltransferases are discussed and metabolic bottlenecks are hypothesized such as the supply of the acetyl-CoA and NADPH. A future industrialization will depend on optimization of chemical compositions and increased biomass production, which can be achieved by exploitation of the physiological potential, by selective breeding and by genetic engineering. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells Zhou Qing; Plath Kathrin; Fan Guoping; Mason Mike J; Horvath Steve Abstract Background Recent work has revealed that a core group of transcription factors (TFs) regulates the key characteristics of embryonic stem (ES) cells: pluripotency and self-renewal. Current efforts focus on identifying genes that play important roles in maintaining pluripotency and self-renewal in ES cells and aim to understand the interactions among these genes. To that end, we... Co-expression network analysis to identify pluripotency biomarkers in bovine and porcine embryos Mazzoni, Gianluca; Freude, Karla Kristine; Hall, Vanessa Jane Differentiated somatic cells can be reprogrammed in induced pluripotent stem cells (iPSCs); a cell type with great potentials in regenerative medicine and in vitro disease modeling. In the pig, we have developed iPSCs, but proper culture conditions for maintaining pluripotency over time are still...... lacking. Hence, there is a need for a more fundamental dissection of the pluripotency apparatus in the pig as well as in cattle. The aim of this study is to analyze RNA-seq data to increase the knowledge about biological pathways in porcine and bovine embryonic pluripotent cell populations exploiting...... the mouse data as proof of principle. In particular we studied cell populations from three different stages of pluripotency after fertilization: the inner cell mass, the epithelial epiblast and the gastrulating epiblast. Reads quality was checked with FASTQC, then the reads were pre-processed using Prinseq... DeYoung Joseph; Langfelder Peter; Fuller Tova F; Blauw Hylke M; van Es Michael A; van Vught Paul WJ; Horvath Steve; Saris Christiaan GJ; Wokke John HJ; Veldink Jan H; van den Berg Leonard H; Ophoff Roel A Abstract Background Amyotrophic Lateral Sclerosis (ALS) is a lethal disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly based on clinical symptoms, and there is currently no therapy to stop the disease or slow its progression. Since access to spinal cord tissue is not possible at disease onset, we investigated changes in... Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model Kogelman, Lisette; Cirera Salicio, Susanna; Zhernakova, Daria V. interactions. Identification of co-expressed and regulatory genes in RNA extracted from relevant tissues representing lean and obese individuals provides an entry point for the identification of genes and pathways of importance to the development of obesity. The pig, an omnivorous animal, is an excellent model...... (modules). Additionally, regulator genes were detected using Lemon-Tree algorithms. Results WGCNA revealed five modules which were strongly correlated with at least one obesity-related phenotype (correlations ranging from -0.54 to 0.72, P ... the association between obesity and other diseases, like osteoporosis (osteoclast differentiation, P = 1.4E-7), and immune-related complications (e.g. Natural killer cell mediated cytotoxity, P = 3.8E-5; B cell receptor signaling pathway, P = 7.2E-5). Lemon-Tree identified three potential regulator genes, using... Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma. Wan, Qi; Tang, Jing; Han, Yu; Wang, Dan Uveal melanoma is an aggressive cancer which has a high percentage recurrence and with a worse prognosis. Identify the potential prognostic markers of uveal melanoma may provide information for early detection of recurrence and treatment. RNA sequence data of uveal melanoma and patient clinic traits were obtained from The Cancer Genome Atlas (TCGA) database. Co-expression modules were built by weighted gene co -expression network analysis (WGCNA) and applied to investigate the relationship underlying modules and clinic traits. Besides, functional enrichment analysis was performed on these co-expression genes from interested modules. First, using WGCNA, identified 21 co-expression modules were constructed by the 10975 genes from the 80 human uveal melanoma samples. The number of genes in these modules ranged from 42 to 5091. Found four co -expression modules significantly correlated with three clinic traits (status, recurrence and recurrence Time). Module red, and purple positively correlated with patient's life status and recurrence Time. Module green positively correlates with recurrence. The result of functional enrichment analysis showed that the module magenta was mainly enriched genetic material assemble processes, the purple module was mainly enriched in tissue homeostasis and melanosome membrane and the module red was mainly enriched metastasis of cell, suggesting its critical role in the recurrence and development of the disease. Additionally, identified the hug gene (top connectivity with other genes) in each module. The hub gene SLC17A7, NTRK2, ABTB1 and ADPRHL1 might play a vital role in recurrence of uveal melanoma. Our findings provided the framework of co-expression gene modules of uveal melanoma and identified some prognostic markers might be detection of recurrence and treatment for uveal melanoma. Copyright Â© 2017 Elsevier Ltd. All rights reserved. A powerful nonparametric method for detecting differentially co-expressed genes: distance correlation screening and edge-count test. Zhang, Qingyang Differential co-expression analysis, as a complement of differential expression analysis, offers significant insights into the changes in molecular mechanism of different phenotypes. A prevailing approach to detecting differentially co-expressed genes is to compare Pearson's correlation coefficients in two phenotypes. However, due to the limitations of Pearson's correlation measure, this approach lacks the power to detect nonlinear changes in gene co-expression which is common in gene regulatory networks. In this work, a new nonparametric procedure is proposed to search differentially co-expressed gene pairs in different phenotypes from large-scale data. Our computational pipeline consisted of two main steps, a screening step and a testing step. The screening step is to reduce the search space by filtering out all the independent gene pairs using distance correlation measure. In the testing step, we compare the gene co-expression patterns in different phenotypes by a recently developed edge-count test. Both steps are distribution-free and targeting nonlinear relations. We illustrate the promise of the new approach by analyzing the Cancer Genome Atlas data and the METABRIC data for breast cancer subtypes. Compared with some existing methods, the new method is more powerful in detecting nonlinear type of differential co-expressions. The distance correlation screening can greatly improve computational efficiency, facilitating its application to large data sets. VTCdb: a gene co-expression database for the crop species Vitis vinifera (grapevine). Wong, Darren C J; Sweetman, Crystal; Drew, Damian P; Ford, Christopher M Gene expression datasets in model plants such as Arabidopsis have contributed to our understanding of gene function and how a single underlying biological process can be governed by a diverse network of genes. The accumulation of publicly available microarray data encompassing a wide range of biological and environmental conditions has enabled the development of additional capabilities including gene co-expression analysis (GCA). GCA is based on the understanding that genes encoding proteins involved in similar and/or related biological processes may exhibit comparable expression patterns over a range of experimental conditions, developmental stages and tissues. We present an open access database for the investigation of gene co-expression networks within the cultivated grapevine, Vitis vinifera. The new gene co-expression database, VTCdb (http://vtcdb.adelaide.edu.au/Home.aspx), offers an online platform for transcriptional regulatory inference in the cultivated grapevine. Using condition-independent and condition-dependent approaches, grapevine co-expression networks were constructed using the latest publicly available microarray datasets from diverse experimental series, utilising the Affymetrix Vitis vinifera GeneChip (16 K) and the NimbleGen Grape Whole-genome microarray chip (29 K), thus making it possible to profile approximately 29,000 genes (95% of the predicted grapevine transcriptome). Applications available with the online platform include the use of gene names, probesets, modules or biological processes to query the co-expression networks, with the option to choose between Affymetrix or Nimblegen datasets and between multiple co-expression measures. Alternatively, the user can browse existing network modules using interactive network visualisation and analysis via CytoscapeWeb. To demonstrate the utility of the database, we present examples from three fundamental biological processes (berry development, photosynthesis and flavonoid biosynthesis Prediction of operon-like gene clusters in the Arabidopsis thaliana genome based on co-expression analysis of neighboring genes. Wada, Masayoshi; Takahashi, Hiroki; Altaf-Ul-Amin, Md; Nakamura, Kensuke; Hirai, Masami Y; Ohta, Daisaku; Kanaya, Shigehiko Operon-like arrangements of genes occur in eukaryotes ranging from yeasts and filamentous fungi to nematodes, plants, and mammals. In plants, several examples of operon-like gene clusters involved in metabolic pathways have recently been characterized, e.g. the cyclic hydroxamic acid pathways in maize, the avenacin biosynthesis gene clusters in oat, the thalianol pathway in Arabidopsis thaliana, and the diterpenoid momilactone cluster in rice. Such operon-like gene clusters are defined by their co-regulation or neighboring positions within immediate vicinity of chromosomal regions. A comprehensive analysis of the expression of neighboring genes therefore accounts a crucial step to reveal the complete set of operon-like gene clusters within a genome. Genome-wide prediction of operon-like gene clusters should contribute to functional annotation efforts and provide novel insight into evolutionary aspects acquiring certain biological functions as well. We predicted co-expressed gene clusters by comparing the Pearson correlation coefficient of neighboring genes and randomly selected gene pairs, based on a statistical method that takes false discovery rate (FDR) into consideration for 1469 microarray gene expression datasets of A. thaliana. We estimated that A. thaliana contains 100 operon-like gene clusters in total. We predicted 34 statistically significant gene clusters consisting of 3 to 22 genes each, based on a stringent FDR threshold of 0.1. Functional relationships among genes in individual clusters were estimated by sequence similarity and functional annotation of genes. Duplicated gene pairs (determined based on BLAST with a cutoff of EOperon-like clusters tend to include genes encoding bio-machinery associated with ribosomes, the ubiquitin/proteasome system, secondary metabolic pathways, lipid and fatty-acid metabolism, and the lipid transfer system. Copyright Â© 2012 Elsevier B.V. All rights reserved. Genome-Scale Co-Expression Network Comparison across Escherichia coli and Salmonella enterica Serovar Typhimurium Reveals Significant Conservation at the Regulon Level of Local Regulators Despite Their Dissimilar Lifestyles Zarrineh, Peyman; SÃ¡nchez-RodrÃguez, Aminael; Hosseinkhan, Nazanin; Narimani, Zahra; Marchal, Kathleen; Masoudi-Nejad, Ali Availability of genome-wide gene expression datasets provides the opportunity to study gene expression across different organisms under a plethora of experimental conditions. In our previous work, we developed an algorithm called COMODO (COnserved MODules across Organisms) that identifies conserved expression modules between two species. In the present study, we expanded COMODO to detect the co-expression conservation across three organisms by adapting the statistics behind it. We applied COMODO to study expression conservation/divergence between Escherichia coli, Salmonella enterica, and Bacillus subtilis. We observed that some parts of the regulatory interaction networks were conserved between E. coli and S. enterica especially in the regulon of local regulators. However, such conservation was not observed between the regulatory interaction networks of B. subtilis and the two other species. We found co-expression conservation on a number of genes involved in quorum sensing, but almost no conservation for genes involved in pathogenicity across E. coli and S. enterica which could partially explain their different lifestyles. We concluded that despite their different lifestyles, no significant rewiring have occurred at the level of local regulons involved for instance, and notable conservation can be detected in signaling pathways and stress sensing in the phylogenetically close species S. enterica and E. coli. Moreover, conservation of local regulons seems to depend on the evolutionary time of divergence across species disappearing at larger distances as shown by the comparison with B. subtilis. Global regulons follow a different trend and show major rewiring even at the limited evolutionary distance that separates E. coli and S. enterica. PMID:25101984 Dynamic sporulation gene co-expression networks for Bacillus subtilis 168 and the food-borne isolate Bacillus amyloliquefaciens : a transcriptomic model Sporulation is a survival strategy, adapted by bacterial cells in response to harsh environmental adversities. The adaptation potential differs between strains and the variations may arise from differences in gene regulation. Gene networks are a valuable way of studying such regulation processes and Ecological network analysis: network construction Fath, B.D.; Scharler, U.M.; Ulanowicz, R.E.; Hannon, B. Ecological network analysis (ENA) is a systems-oriented methodology to analyze within system interactions used to identify holistic properties that are otherwise not evident from the direct observations. Like any analysis technique, the accuracy of the results is as good as the data available, but A stochastic model for identifying differential gene pair co-expression patterns in prostate cancer progression Mao Yu Full Text Available Abstract Background The identification of gene differential co-expression patterns between cancer stages is a newly developing method to reveal the underlying molecular mechanisms of carcinogenesis. Most researches of this subject lack an algorithm useful for performing a statistical significance assessment involving cancer progression. Lacking this specific algorithm is apparently absent in identifying precise gene pairs correlating to cancer progression. Results In this investigation we studied gene pair co-expression change by using a stochastic process model for approximating the underlying dynamic procedure of the co-expression change during cancer progression. Also, we presented a novel analytical method named 'Stochastic process model for Identifying differentially co-expressed Gene pair' (SIG method. This method has been applied to two well known prostate cancer data sets: hormone sensitive versus hormone resistant, and healthy versus cancerous. From these data sets, 428,582 gene pairs and 303,992 gene pairs were identified respectively. Afterwards, we used two different current statistical methods to the same data sets, which were developed to identify gene pair differential co-expression and did not consider cancer progression in algorithm. We then compared these results from three different perspectives: progression analysis, gene pair identification effectiveness analysis, and pathway enrichment analysis. Statistical methods were used to quantify the quality and performance of these different perspectives. They included: Re-identification Scale (RS and Progression Score (PS in progression analysis, True Positive Rate (TPR in gene pair analysis, and Pathway Enrichment Score (PES in pathway analysis. Our results show small values of RS and large values of PS, TPR, and PES; thus, suggesting that gene pairs identified by the SIG method are highly correlated with cancer progression, and highly enriched in disease-specific pathways. From WGCNA: an R package for weighted correlation network analysis. Langfelder, Peter; Horvath, Steve Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray samples. Weighted correlation network analysis (WGCNA) can be used for finding clusters (modules) of highly correlated genes, for summarizing such clusters using the module eigengene or an intramodular hub gene, for relating modules to one another and to external sample traits (using eigengene network methodology), and for calculating module membership measures. Correlation networks facilitate network based gene screening methods that can be used to identify candidate biomarkers or therapeutic targets. These methods have been successfully applied in various biological contexts, e.g. cancer, mouse genetics, yeast genetics, and analysis of brain imaging data. While parts of the correlation network methodology have been described in separate publications, there is a need to provide a user-friendly, comprehensive, and consistent software implementation and an accompanying tutorial. The WGCNA R software package is a comprehensive collection of R functions for performing various aspects of weighted correlation network analysis. The package includes functions for network construction, module detection, gene selection, calculations of topological properties, data simulation, visualization, and interfacing with external software. Along with the R package we also present R software tutorials. While the methods development was motivated by gene expression data, the underlying data mining approach can be applied to a variety of different settings. The WGCNA package provides R functions for weighted correlation network analysis, e.g. co-expression network analysis of gene expression data. The R package along with its source code and additional material are freely available at http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/Rpackages/WGCNA. Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma. Grinchuk, Oleg V; Yenamandra, Surya P; Iyer, Ramakrishnan; Singh, Malay; Lee, Hwee Kuan; Lim, Kiat Hon; Chow, Pierce Kah-Hoe; Kuznetsov, Vladamir A Currently, molecular markers are not used when determining the prognosis and treatment strategy for patients with hepatocellular carcinoma (HCC). In the present study, we proposed that the identification of common pro-oncogenic pathways in primary tumors (PT) and adjacent non-malignant tissues (AT) typically used to predict HCC patient risks may result in HCC biomarker discovery. We examined the genome-wide mRNA expression profiles of paired PT and AT samples from 321 HCC patients. The workflow integrated differentially expressed gene selection, gene ontology enrichment, computational classification, survival predictions, image analysis and experimental validation methods. We developed a 24-ribosomal gene-based HCC classifier (RGC), which is prognostically significant in both PT and AT. The RGC gene overexpression in PT was associated with a poor prognosis in the training (hazard ratioÂ =Â 8.2, PÂ =Â 9.4Â Ã—Â 10 -6 ) and cross-cohort validation (hazard ratioÂ =Â 2.63, PÂ =Â 0.004) datasets. The multivariate survival analysis demonstrated the significant and independent prognostic value of the RGC. The RGC displayed a significant prognostic value in AT of the training (hazard ratioÂ =Â 5.0, PÂ =Â 0.03) and cross-validation (hazard ratioÂ =Â 1.9, PÂ =Â 0.03) HCC groups, confirming the accuracy and robustness of the RGC. Our experimental and bioinformatics analyses suggested a key role for c-MYC in the pro-oncogenic pattern of ribosomal biogenesis co-regulation in PT and AT. Microarray, quantitative RT-PCR and quantitative immunohistochemical studies of the PT showed that DKK1 in PT is the perspective biomarker for poor HCC outcomes. The common co-transcriptional pattern of ribosome biogenesis genes in PT and AT from HCC patients suggests a new scalable prognostic system, as supported by the model of tumor-like metabolic redirection/assimilation in non-malignant AT. The RGC, comprising 24 ribosomal genes, is introduced as a robust and reproducible prognostic model for Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811. Doll, Corinne M; Moughan, Jennifer; Klimowicz, Alexander; Ho, Clement K; Kornaga, Elizabeth N; Lees-Miller, Susan P; Ajani, Jaffer A; Crane, Christopher H; Kachnic, Lisa A; Okawara, Gordon S; Berk, Lawrence B; Roof, Kevin S; Becker, Mark J; Grisell, David L; Ellis, Robert J; Sperduto, Paul W; Marsa, Gerald W; Guha, Chandan; Magliocco, Anthony M To measure co-expression of EGFR and Ki67 proteins in pretreatment tumor biopsies of anal cancer patients enrolled on NRG Oncology RTOG 9811, a phase III trial comparing 5-fluorouracil/mitomycin-C/radiation therapy (Arm A) versus 5-fluorouracil/cisplatin/radiation therapy (Arm B), and to correlate expression with clinical outcome. EGFR and Ki67 co-expression was measured after constructing a tissue microarray using fluorescence immunohistochemistry and automated quantitative image analysis. The Ki67 score within EGFR high versus low areas (Ki67ratio in EGFR high:low ) in each tumor core was analyzed at the median, quartiles, and as a continuous variable. Associations between the tumor markers and clinical endpoints (overall and disease-free survival, locoregional and colostomy failure, and distant metastases) were explored. A total of 282 pretreatment tumors were analyzed from NRG Oncology RTOG 9811. Of evaluated specimens, 183 (65%, n=89, Arm A; n=94, Arm B) were eligible and analyzable. There were no significant differences in baseline characteristics or outcomes between analyzable and unanalyzable patient cases. Median follow-up was 6.0Â years. On multivariate analysis, after adjusting for gender, patients with Ki67ratio in EGFR high:low Â â‰¥median had worse overall survival (hazard ratio 2.41, 95% confidence interval 1.38-4.19, P=.0019). After adjusting for N stage and largest tumor dimension, patients with Ki67ratio in EGFR high:low Â â‰¥Â median had a higher risk of a disease-free failure (hazard ratio 1.85, 95% confidence interval 1.18-2.92, P=.0078). Technical validation with an independent anal cancer patient cohort was performed and shows a very similar biomarker score distribution. High Ki67ratio in EGFR high:low is associated with worse clinical outcome in this subset of patients with anal cancer treated with chemoradiation on NRG Oncology RTOG 9811. Evaluation within a clinical trial will be required to determine whether patients with these tumor Communication Network Analysis Methods. Farace, Richard V.; Mabee, Timothy This paper reviews a variety of analytic procedures that can be applied to network data, discussing the assumptions and usefulness of each procedure when applied to the complexity of human communication. Special attention is paid to the network properties measured or implied by each procedure. Factor analysis and multidimensional scaling are amongâ€¦ Co-Expression of Neighboring Genes in the Zebrafish (Danio rerio Genome Daryi Wang Full Text Available Neighboring genes in the eukaryotic genome have a tendency to express concurrently, and the proximity of two adjacent genes is often considered a possible explanation for their co-expression behavior. However, the actual contribution of the physical distance between two genes to their co-expression behavior has yet to be defined. To further investigate this issue, we studied the co-expression of neighboring genes in zebrafish, which has a compact genome and has experienced a whole genome duplication event. Our analysis shows that the proportion of highly co-expressed neighboring pairs (Pearsonâ€™s correlation coefficient R>0.7 is low (0.24% ~ 0.67%; however, it is still significantly higher than that of random pairs. In particular, the statistical result implies that the co-expression tendency of neighboring pairs is negatively correlated with their physical distance. Our findings therefore suggest that physical distance may play an important role in the co-expression of neighboring genes. Possible mechanisms related to the neighboring genesâ€™ co-expression are also discussed. Improvisation and co-expression in explorative digital music systems Hansen, Anne-Marie Skriver relationships. The benefit of the digitally networked electronic musical instruments is that particular patterns of co-expression can be found and mediated by the music system (that also contains all individual instruments) in ways that make players aware of their mutual play and perhaps will encourage players...... other when they are given a number of creative restrictions in the sonic/musical material that they interact with. The benefit with digital musical instruments is that non-musicians and novices can get access to limited musical material that they are immediately able to master without any musical...... be developed in future designs. The WacomÂ® pen tablet, a simple drawing interface, was turned into an array of digital musical instruments in order to investigate the benefit of networked musical instruments in the context of the genre of casual games. Through qualitative and quantitative studies of player... Gene expression patterns combined with network analysis identify hub genes associated with bladder cancer. Bi, Dongbin; Ning, Hao; Liu, Shuai; Que, Xinxiang; Ding, Kejia To explore molecular mechanisms of bladder cancer (BC), network strategy was used to find biomarkers for early detection and diagnosis. The differentially expressed genes (DEGs) between bladder carcinoma patients and normal subjects were screened using empirical Bayes method of the linear models for microarray data package. Co-expression networks were constructed by differentially co-expressed genes and links. Regulatory impact factors (RIF) metric was used to identify critical transcription factors (TFs). The protein-protein interaction (PPI) networks were constructed by the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and clusters were obtained through molecular complex detection (MCODE) algorithm. Centralities analyses for complex networks were performed based on degree, stress and betweenness. Enrichment analyses were performed based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Co-expression networks and TFs (based on expression data of global DEGs and DEGs in different stages and grades) were identified. Hub genes of complex networks, such as UBE2C, ACTA2, FABP4, CKS2, FN1 and TOP2A, were also obtained according to analysis of degree. In gene enrichment analyses of global DEGs, cell adhesion, proteinaceous extracellular matrix and extracellular matrix structural constituent were top three GO terms. ECM-receptor interaction, focal adhesion, and cell cycle were significant pathways. Our results provide some potential underlying biomarkers of BC. However, further validation is required and deep studies are needed to elucidate the pathogenesis of BC. Copyright Â© 2015 Elsevier Ltd. All rights reserved. Network performance analysis Bonald, Thomas The book presents some key mathematical tools for the performance analysis of communication networks and computer systems.Communication networks and computer systems have become extremely complex. The statistical resource sharing induced by the random behavior of users and the underlying protocols and algorithms may affect Quality of Service.This book introduces the main results of queuing theory that are useful for analyzing the performance of these systems. These mathematical tools are key to the development of robust dimensioning rules and engineering methods. A number of examples i Network systems security analysis Yilmaz, Ã„.Â°smail Network Systems Security Analysis has utmost importance in today's world. Many companies, like banks which give priority to data management, test their own data security systems with "Penetration Tests" by time to time. In this context, companies must also test their own network/server systems and take precautions, as the data security draws attention. Based on this idea, the study cyber-attacks are researched throughoutly and Penetration Test technics are examined. With these information on, classification is made for the cyber-attacks and later network systems' security is tested systematically. After the testing period, all data is reported and filed for future reference. Consequently, it is found out that human beings are the weakest circle of the chain and simple mistakes may unintentionally cause huge problems. Thus, it is clear that some precautions must be taken to avoid such threats like updating the security software. Analysis of computer networks Gebali, Fayez This textbook presents the mathematical theory and techniques necessary for analyzing and modeling high-performance global networks, such as the Internet. The three main building blocks of high-performance networks are links, switching equipment connecting the links together, and software employed at the end nodes and intermediate switches. This book provides the basic techniques for modeling and analyzing these last two components. Topics covered include, but are not limited to: Markov chains and queuing analysis, traffic modeling, interconnection networks and switch architectures and buffering strategies. Â Â·Â Â Â Â Â Â Â Â Provides techniques for modeling and analysis of network software and switching equipment; Â·Â Â Â Â Â Â Â Â Discusses design options used to build efficient switching equipment; Â·Â Â Â Â Â Â Â Â Includes many worked examples of the application of discrete-time Markov chains to communication systems; Â·Â Â Â Â Â Â Â Â Covers the mathematical theory and techniques necessary for ana... Comparison of co-expression measures: mutual information, correlation, and model based indices. Song, Lin; Langfelder, Peter; Horvath, Steve Co-expression measures are often used to define networks among genes. Mutual information (MI) is often used as a generalized correlation measure. It is not clear how much MI adds beyond standard (robust) correlation measures or regression model based association measures. Further, it is important to assess what transformations of these and other co-expression measures lead to biologically meaningful modules (clusters of genes). We provide a comprehensive comparison between mutual information and several correlation measures in 8 empirical data sets and in simulations. We also study different approaches for transforming an adjacency matrix, e.g. using the topological overlap measure. Overall, we confirm close relationships between MI and correlation in all data sets which reflects the fact that most gene pairs satisfy linear or monotonic relationships. We discuss rare situations when the two measures disagree. We also compare correlation and MI based approaches when it comes to defining co-expression network modules. We show that a robust measure of correlation (the biweight midcorrelation transformed via the topological overlap transformation) leads to modules that are superior to MI based modules and maximal information coefficient (MIC) based modules in terms of gene ontology enrichment. We present a function that relates correlation to mutual information which can be used to approximate the mutual information from the corresponding correlation coefficient. We propose the use of polynomial or spline regression models as an alternative to MI for capturing non-linear relationships between quantitative variables. The biweight midcorrelation outperforms MI in terms of elucidating gene pairwise relationships. Coupled with the topological overlap matrix transformation, it often leads to more significantly enriched co-expression modules. Spline and polynomial networks form attractive alternatives to MI in case of non-linear relationships. Our results indicate that MI Genes and co-expression modules common to drought and bacterial stress responses in Arabidopsis and rice. Rafi Shaik Full Text Available Plants are simultaneously exposed to multiple stresses resulting in enormous changes in the molecular landscape within the cell. Identification and characterization of the synergistic and antagonistic components of stress response mechanisms contributing to the cross talk between stresses is of high priority to explore and enhance multiple stress responses. To this end, we performed meta-analysis of drought (abiotic, bacterial (biotic stress response in rice and Arabidopsis by analyzing a total of 386 microarray samples belonging to 20 microarray studies and identified approximately 3100 and 900 DEGs in rice and Arabidopsis, respectively. About 38.5% (1214 and 28.7% (272 DEGs were common to drought and bacterial stresses in rice and Arabidopsis, respectively. A majority of these common DEGs showed conserved expression status in both stresses. Gene ontology enrichment analysis clearly demarcated the response and regulation of various plant hormones and related biological processes. Fatty acid metabolism and biosynthesis of alkaloids were upregulated and, nitrogen metabolism and photosynthesis was downregulated in both stress conditions. WRKY transcription family genes were highly enriched in all upregulated gene sets while 'CO-like' TF family showed inverse relationship of expression between drought and bacterial stresses. Weighted gene co-expression network analysis divided DEG sets into multiple modules that show high co-expression and identified stress specific hub genes with high connectivity. Detection of consensus modules based on DEGs common to drought and bacterial stress revealed 9 and 4 modules in rice and Arabidopsis, respectively, with conserved and reversed co-expression patterns. Multifractal analysis of complex networks Wang Dan-Ling; Yu Zu-Guo; Anh V Complex networks have recently attracted much attention in diverse areas of science and technology. Many networks such as the WWW and biological networks are known to display spatial heterogeneity which can be characterized by their fractal dimensions. Multifractal analysis is a useful way to systematically describe the spatial heterogeneity of both theoretical and experimental fractal patterns. In this paper, we introduce a new box-covering algorithm for multifractal analysis of complex networks. This algorithm is used to calculate the generalized fractal dimensions D q of some theoretical networks, namely scale-free networks, small world networks, and random networks, and one kind of real network, namely proteinâ€”protein interaction networks of different species. Our numerical results indicate the existence of multifractality in scale-free networks and proteinâ€”protein interaction networks, while the multifractal behavior is not clear-cut for small world networks and random networks. The possible variation of D q due to changes in the parameters of the theoretical network models is also discussed. (general) Network Analysis, Architecture, and Design McCabe, James D Traditionally, networking has had little or no basis in analysis or architectural development, with designers relying on technologies they are most familiar with or being influenced by vendors or consultants. However, the landscape of networking has changed so that network services have now become one of the most important factors to the success of many third generation networks. It has become an important feature of the designer's job to define the problems that exist in his network, choose and analyze several optimization parameters during the analysis process, and then prioritize and evalua Network topology analysis. Kalb, Jeffrey L.; Lee, David S. Emerging high-bandwidth, low-latency network technology has made network-based architectures both feasible and potentially desirable for use in satellite payload architectures. The selection of network topology is a critical component when developing these multi-node or multi-point architectures. This study examines network topologies and their effect on overall network performance. Numerous topologies were reviewed against a number of performance, reliability, and cost metrics. This document identifies a handful of good network topologies for satellite applications and the metrics used to justify them as such. Since often multiple topologies will meet the requirements of the satellite payload architecture under development, the choice of network topology is not easy, and in the end the choice of topology is influenced by both the design characteristics and requirements of the overall system and the experience of the developer. Differential network analysis reveals evolutionary complexity in secondary metabolism of Rauvolfia serpentina over Catharanthus roseus Shivalika Pathania Full Text Available Comparative co-expression analysis of multiple species using high-throughput data is an integrative approach to determine the uniformity as well as diversification in biological processes. Rauvolfia serpentina and Catharanthus roseus, both members of Apocyanacae family, are reported to have remedial properties against multiple diseases. Despite of sharing upstream of terpenoid indole alkaloid pathway, there is significant diversity in tissue-specific synthesis and accumulation of specialized metabolites in these plants. This led us to implement comparative co-expression network analysis to investigate the modules and genes responsible for differential tissue-specific expression as well as species-specific synthesis of metabolites. Towards these goals differential network analysis was implemented to identify candidate genes responsible for diversification of metabolites profile. Three genes were identified with significant difference in connectivity leading to differential regulatory behavior between these plants. These mechanisms may be responsible for diversification of secondary metabolism, and thereby for species-specific metabolite synthesis. The network robustness of R. serpentina, determined based on topological properties, was also complemented by comparison of gene-metabolite networks of both plants, and may have evolved to have complex metabolic mechanisms as compared to C. roseus under the influence of various stimuli. This study reveals evolution of complexity in secondary metabolism of Rauvolfia serpentina, and key genes that contribute towards diversification of specific metabolites. Differential Network Analysis Reveals Evolutionary Complexity in Secondary Metabolism of Rauvolfia serpentina over Catharanthus roseus. Pathania, Shivalika; Bagler, Ganesh; Ahuja, Paramvir S Comparative co-expression analysis of multiple species using high-throughput data is an integrative approach to determine the uniformity as well as diversification in biological processes. Rauvolfia serpentina and Catharanthus roseus, both members of Apocyanacae family, are reported to have remedial properties against multiple diseases. Despite of sharing upstream of terpenoid indole alkaloid pathway, there is significant diversity in tissue-specific synthesis and accumulation of specialized metabolites in these plants. This led us to implement comparative co-expression network analysis to investigate the modules and genes responsible for differential tissue-specific expression as well as species-specific synthesis of metabolites. Toward these goals differential network analysis was implemented to identify candidate genes responsible for diversification of metabolites profile. Three genes were identified with significant difference in connectivity leading to differential regulatory behavior between these plants. These genes may be responsible for diversification of secondary metabolism, and thereby for species-specific metabolite synthesis. The network robustness of R. serpentina, determined based on topological properties, was also complemented by comparison of gene-metabolite networks of both plants, and may have evolved to have complex metabolic mechanisms as compared to C. roseus under the influence of various stimuli. This study reveals evolution of complexity in secondary metabolism of R. serpentina, and key genes that contribute toward diversification of specific metabolites. EMMPRIN co-expressed with matrix metalloproteinases predicts poor prognosis in patients with osteosarcoma. Futamura, Naohisa; Nishida, Yoshihiro; Urakawa, Hiroshi; Kozawa, Eiji; Ikuta, Kunihiro; Hamada, Shunsuke; Ishiguro, Naoki Several studies have focused on the relationships between the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the prognosis of patients with malignant tumors. However, few of these have investigated the expression of EMMPRIN in osteosarcoma. We examined expression levels of EMMPRIN immunohistochemically in 53 cases of high-grade osteosarcoma of the extremities and analyzed the correlation of its expression with patient prognosis. The correlation between matrix metalloproteinases (MMPs) and EMMPRIN expression and the prognostic value of co-expression were also analyzed. Staining positivity for EMMPRIN was negative in 7 cases, low in 17, moderate in 19, and strong in 10. The overall and disease-free survivals (OS and DFS) in patients with higher EMMPRIN expression (strong-moderate) were significantly lower than those in the lower (weak-negative) group (0.037 and 0.024, respectively). In multivariate analysis, age (P=0.004), location (P=0.046), and EMMPRIN expression (P=0.038) were significant prognostic factors for overall survival. EMMPRIN expression (P=0.024) was also a significant prognostic factor for disease-free survival. Co-expression analyses of EMMPRIN and MMPs revealed that strong co-expression of EMMPRIN and membrane-type 1 (MT1)-MMP had a poor prognostic value (P=0.056 for DFS, P=0.006 for OS). EMMPRIN expression and co-expression with MMPs well predict the prognosis of patients with extremity osteosarcoma, making EMMPRIN a possible therapeutic target in these patients. Artificial Neural Network Analysis System Contract No. DASG60-00-M-0201 Purchase request no.: Foot in the Door-01 Title Name: Artificial Neural Network Analysis System Company: Atlantic... Artificial Neural Network Analysis System 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Powell, Bruce C 5d. PROJECT NUMBER 5e. TASK NUMBER...34) 27-02-2001 Report Type N/A Dates Covered (from... to) ("DD MON YYYY") 28-10-2000 27-02-2001 Title and Subtitle Artificial Neural Network Analysis Discovery of cis-elements between sorghum and rice using co-expression and evolutionary conservation Haberer Georg Full Text Available Abstract Background The spatiotemporal regulation of gene expression largely depends on the presence and absence of cis-regulatory sites in the promoter. In the economically highly important grass family, our knowledge of transcription factor binding sites and transcriptional networks is still very limited. With the completion of the sorghum genome and the available rice genome sequence, comparative promoter analyses now allow genome-scale detection of conserved cis-elements. Results In this study, we identified thousands of phylogenetic footprints conserved between orthologous rice and sorghum upstream regions that are supported by co-expression information derived from three different rice expression data sets. In a complementary approach, cis-motifs were discovered by their highly conserved co-occurrence in syntenic promoter pairs. Sequence conservation and matches to known plant motifs support our findings. Expression similarities of gene pairs positively correlate with the number of motifs that are shared by gene pairs and corroborate the importance of similar promoter architectures for concerted regulation. This strongly suggests that these motifs function in the regulation of transcript levels in rice and, presumably also in sorghum. Conclusion Our work provides the first large-scale collection of cis-elements for rice and sorghum and can serve as a paradigm for cis-element analysis through comparative genomics in grasses in general. Computational Social Network Analysis Hassanien, Aboul-Ella Presents insight into the social behaviour of animals (including the study of animal tracks and learning by members of the same species). This book provides web-based evidence of social interaction, perceptual learning, information granulation and the behaviour of humans and affinities between web-based social networks Network analysis applications in hydrology Price, Katie Applied network theory has seen pronounced expansion in recent years, in fields such as epidemiology, computer science, and sociology. Concurrent development of analytical methods and frameworks has increased possibilities and tools available to researchers seeking to apply network theory to a variety of problems. While water and nutrient fluxes through stream systems clearly demonstrate a directional network structure, the hydrological applications of network theory remain underÂexplored. This presentation covers a review of network applications in hydrology, followed by an overview of promising network analytical tools that potentially offer new insights into conceptual modeling of hydrologic systems, identifying behavioral transition zones in stream networks and thresholds of dynamical system response. Network applications were tested along an urbanization gradient in Atlanta, Georgia, USA. Peachtree Creek and Proctor Creek. Peachtree Creek contains a nest of five longÂterm USGS streamflow and water quality gages, allowing network application of longÂterm flow statistics. The watershed spans a range of suburban and heavily urbanized conditions. Summary flow statistics and water quality metrics were analyzed using a suite of network analysis techniques, to test the conceptual modeling and predictive potential of the methodologies. Storm events and low flow dynamics during Summer 2016 were analyzed using multiple network approaches, with an emphasis on tomogravity methods. Results indicate that network theory approaches offer novel perspectives for understanding longÂ term and eventÂbased hydrological data. Key future directions for network applications include 1) optimizing data collection, 2) identifying "hotspots" of contaminant and overland flow influx to stream systems, 3) defining process domains, and 4) analyzing dynamic connectivity of various system components, including groundwaterÂsurface water interactions. Analysis of neural networks Heiden, Uwe The purpose of this work is a unified and general treatment of activity in neural networks from a mathematical pOint of view. Possible applications of the theory presented are indicaÂ ted throughout the text. However, they are not explored in deÂ tail for two reasons : first, the universal character of n- ral activity in nearly all animals requires some type of a general approach~ secondly, the mathematical perspicuity would suffer if too many experimental details and empirical peculiarities were interspersed among the mathematical investigation. A guide to many applications is supplied by the references concerning a variety of specific issues. Of course the theory does not aim at covering all individual problems. Moreover there are other approaches to neural network theory (see e.g. Poggio-Torre, 1978) based on the different levÂ els at which the nervous system may be viewed. The theory is a deterministic one reflecting the average beÂ havior of neurons or neuron pools. In this respect the essay is writt... Transmission analysis in WDM networks Rasmussen, Christian JÃ¸rgen This thesis describes the development of a computer-based simulator for transmission analysis in optical wavelength division multiplexing networks. A great part of the work concerns fundamental optical network simulator issues. Among these issues are identification of the versatility and user...... the different component models are invoked during the simulation of a system. A simple set of rules which makes it possible to simulate any network architectures is laid down. The modelling of the nonlinear fibre and the optical receiver is also treated. The work on the fibre concerns the numerical solution... Modular analysis of biological networks. Kaltenbach, Hans-Michael; Stelling, JÃ¶rg The analysis of complex biological networks has traditionally relied on decomposition into smaller, semi-autonomous units such as individual signaling pathways. With the increased scope of systems biology (models), rational approaches to modularization have become an important topic. With increasing acceptance of de facto modularity in biology, widely different definitions of what constitutes a module have sparked controversies. Here, we therefore review prominent classes of modular approaches based on formal network representations. Despite some promising research directions, several important theoretical challenges remain open on the way to formal, function-centered modular decompositions for dynamic biological networks. Large-scale analysis of Arabidopsis transcription reveals a basal co-regulation network Chamovitz Daniel A Full Text Available Abstract Background Analyses of gene expression data from microarray experiments has become a central tool for identifying co-regulated, functional gene modules. A crucial aspect of such analysis is the integration of data from different experiments and different laboratories. How to weigh the contribution of different experiments is an important point influencing the final outcomes. We have developed a novel method for this integration, and applied it to genome-wide data from multiple Arabidopsis microarray experiments performed under a variety of experimental conditions. The goal of this study is to identify functional globally co-regulated gene modules in the Arabidopsis genome. Results Following the analysis of 21,000 Arabidopsis genes in 43 datasets and about 2 Ã— 108 gene pairs, we identified a globally co-expressed gene network. We found clusters of globally co-expressed Arabidopsis genes that are enriched for known Gene Ontology annotations. Two types of modules were identified in the regulatory network that differed in their sensitivity to the node-scoring parameter; we further showed these two pertain to general and specialized modules. Some of these modules were further investigated using the Genevestigator compendium of microarray experiments. Analyses of smaller subsets of data lead to the identification of condition-specific modules. Conclusion Our method for identification of gene clusters allows the integration of diverse microarray experiments from many sources. The analysis reveals that part of the Arabidopsis transcriptome is globally co-expressed, and can be further divided into known as well as novel functional gene modules. Our methodology is general enough to apply to any set of microarray experiments, using any scoring function. Antenna analysis using neural networks Smith, William T. Conventional computing schemes have long been used to analyze problems in electromagnetics (EM). The vast majority of EM applications require computationally intensive algorithms involving numerical integration and solutions to large systems of equations. The feasibility of using neural network computing algorithms for antenna analysis is investigated. The ultimate goal is to use a trained neural network algorithm to reduce the computational demands of existing reflector surface error compensation techniques. Neural networks are computational algorithms based on neurobiological systems. Neural nets consist of massively parallel interconnected nonlinear computational elements. They are often employed in pattern recognition and image processing problems. Recently, neural network analysis has been applied in the electromagnetics area for the design of frequency selective surfaces and beam forming networks. The backpropagation training algorithm was employed to simulate classical antenna array synthesis techniques. The Woodward-Lawson (W-L) and Dolph-Chebyshev (D-C) array pattern synthesis techniques were used to train the neural network. The inputs to the network were samples of the desired synthesis pattern. The outputs are the array element excitations required to synthesize the desired pattern. Once trained, the network is used to simulate the W-L or D-C techniques. Various sector patterns and cosecant-type patterns (27 total) generated using W-L synthesis were used to train the network. Desired pattern samples were then fed to the neural network. The outputs of the network were the simulated W-L excitations. A 20 element linear array was used. There were 41 input pattern samples with 40 output excitations (20 real parts, 20 imaginary). A comparison between the simulated and actual W-L techniques is shown for a triangular-shaped pattern. Dolph-Chebyshev is a different class of synthesis technique in that D-C is used for side lobe control as opposed to pattern NET-2 Network Analysis Program Malmberg, A.F. The NET-2 Network Analysis Program is a general purpose digital computer program which solves the nonlinear time domain response and the linearized small signal frequency domain response of an arbitrary network of interconnected components. NET-2 is capable of handling a variety of components and has been applied to problems in several engineering fields, including electronic circuit design and analysis, missile flight simulation, control systems, heat flow, fluid flow, mechanical systems, structural dynamics, digital logic, communications network design, solid state device physics, fluidic systems, and nuclear vulnerability due to blast, thermal, gamma radiation, neutron damage, and EMP effects. Network components may be selected from a repertoire of built-in models or they may be constructed by the user through appropriate combinations of mathematical, empirical, and topological functions. Higher-level components may be defined by subnetworks composed of any combination of user-defined components and built-in models. The program provides a modeling capability to represent and intermix system components on many levels, e.g., from hole and electron spatial charge distributions in solid state devices through discrete and integrated electronic components to functional system blocks. NET-2 is capable of simultaneous computation in both the time and frequency domain, and has statistical and optimization capability. Network topology may be controlled as a function of the network solution. (U.S.) Network Analysis Tools: from biological networks to clusters and pathways. BrohÃ©e, Sylvain; Faust, Karoline; Lima-Mendez, Gipsi; Vanderstocken, Gilles; van Helden, Jacques Network Analysis Tools (NeAT) is a suite of computer tools that integrate various algorithms for the analysis of biological networks: comparison between graphs, between clusters, or between graphs and clusters; network randomization; analysis of degree distribution; network-based clustering and path finding. The tools are interconnected to enable a stepwise analysis of the network through a complete analytical workflow. In this protocol, we present a typical case of utilization, where the tasks above are combined to decipher a protein-protein interaction network retrieved from the STRING database. The results returned by NeAT are typically subnetworks, networks enriched with additional information (i.e., clusters or paths) or tables displaying statistics. Typical networks comprising several thousands of nodes and arcs can be analyzed within a few minutes. The complete protocol can be read and executed in approximately 1 h. Statistical network analysis for analyzing policy networks Robins, Garry; Lewis, Jenny; Wang, Peng and policy network methodology is the development of statistical modeling approaches that can accommodate such dependent data. In this article, we review three network statistical methods commonly used in the current literature: quadratic assignment procedures, exponential random graph models (ERGMs......To analyze social network data using standard statistical approaches is to risk incorrect inference. The dependencies among observations implied in a network conceptualization undermine standard assumptions of the usual general linear models. One of the most quickly expanding areas of social......), and stochastic actor-oriented models. We focus most attention on ERGMs by providing an illustrative example of a model for a strategic information network within a local government. We draw inferences about the structural role played by individuals recognized as key innovators and conclude that such an approach... Statistical analysis of network data with R Kolaczyk, Eric D Networks have permeated everyday life through everyday realities like the Internet, social networks, and viral marketing. As such, network analysis is an important growth area in the quantitative sciences, with roots in social network analysis going back to the 1930s and graph theory going back centuries. Measurement and analysis are integral components of network research. As a result, statistical methods play a critical role in network analysis. This book is the first of its kind in network research. It can be used as a stand-alone resource in which multiple R packages are used to illustrate how to conduct a wide range of network analyses, from basic manipulation and visualization, to summary and characterization, to modeling of network data. The central package is igraph, which provides extensive capabilities for studying network graphs in R. This text builds on Eric D. Kolaczykâ€™s book Statistical Analysis of Network Data (Springer, 2009). Large clusters of co-expressed genes in the Drosophila genome. Boutanaev, Alexander M; Kalmykova, Alla I; Shevelyov, Yuri Y; Nurminsky, Dmitry I Clustering of co-expressed, non-homologous genes on chromosomes implies their co-regulation. In lower eukaryotes, co-expressed genes are often found in pairs. Clustering of genes that share aspects of transcriptional regulation has also been reported in higher eukaryotes. To advance our understanding of the mode of coordinated gene regulation in multicellular organisms, we performed a genome-wide analysis of the chromosomal distribution of co-expressed genes in Drosophila. We identified a total of 1,661 testes-specific genes, one-third of which are clustered on chromosomes. The number of clusters of three or more genes is much higher than expected by chance. We observed a similar trend for genes upregulated in the embryo and in the adult head, although the expression pattern of individual genes cannot be predicted on the basis of chromosomal position alone. Our data suggest that the prevalent mechanism of transcriptional co-regulation in higher eukaryotes operates with extensive chromatin domains that comprise multiple genes. Analysis of Semantic Networks using Complex Networks Concepts Ortiz-Arroyo, Daniel In this paper we perform a preliminary analysis of semantic networks to determine the most important terms that could be used to optimize a summarization task. In our experiments, we measure how the properties of a semantic network change, when the terms in the network are removed. Our preliminar... Spectral Analysis of Rich Network Topology in Social Networks Wu, Leting Social networks have received much attention these days. Researchers have developed different methods to study the structure and characteristics of the network topology. Our focus is on spectral analysis of the adjacency matrix of the underlying network. Recent work showed good properties in the adjacency spectral space but there are fewâ€¦ Complex Network Analysis of Guangzhou Metro Yasir Tariq Mohmand; Fahad Mehmood; Fahd Amjad; Nedim Makarevic The structure and properties of public transportation networks can provide suggestions for urban planning and public policies. This study contributes a complex network analysis of the Guangzhou metro. The metro network has 236 kilometers of track and is the 6th busiest metro system of the world. In this paper topological properties of the network are explored. We observed that the network displays small world properties and is assortative in nature. The network possesses a high average degree... COalitions in COOperation Networks (COCOON): Social Network Analysis and Game Theory to Enhance Cooperation Networks Sie, Rory Sie, R. L. L. (2012). COalitions in COOperation Networks (COCOON): Social Network Analysis and Game Theory to Enhance Cooperation Networks (Unpublished doctoral dissertation). September, 28, 2012, Open Universiteit in the Netherlands (CELSTEC), Heerlen, The Netherlands. Evolutionary Analysis of DELLA-Associated Transcriptional Networks Miguel A. BlÃ¡zquez Full Text Available DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental information to pre-wired transcriptional circuits because their stability is regulated by gibberellins (GAs, whose homeostasis largely depends on environmental signals. The ability of GAs to promote DELLA degradation coincides with the origin of vascular plants, but the presence of DELLAs in other land plants poses at least two questions: what regulatory properties have DELLAs provided to the behavior of transcriptional networks in land plants, and how has the recruitment of DELLAs by GA signaling affected this regulation. To address these issues, we have constructed gene co-expression networks of four different organisms within the green lineage with different properties regarding DELLAs: Arabidopsis thaliana and Solanum lycopersicum (both with GA-regulated DELLA proteins, Physcomitrella patens (with GA-independent DELLA proteins and Chlamydomonas reinhardtii (a green alga without DELLA, and we have examined the relative evolution of the subnetworks containing the potential DELLA-dependent transcriptomes. Network analysis indicates a relative increase in parameters associated with the degree of interconnectivity in the DELLA-associated subnetworks of land plants, with a stronger effect in species with GA-regulated DELLA proteins. These results suggest that DELLAs may have played a role in the coordination of multiple transcriptional programs along evolution, and the function of DELLAs as regulatory â€˜hubsâ€™ became further consolidated after their recruitment by GA signaling in higher plants. Networks and network analysis for defence and security Masys, Anthony J Networks and Network Analysis for Defence and Security discusses relevant theoretical frameworks and applications of network analysis in support of the defence and security domains. This book details real world applications of network analysis to support defence and security. Shocks to regional, national and global systems stemming from natural hazards, acts of armed violence, terrorism and serious and organized crime have significant defence and security implications. Today, nations face an uncertain and complex security landscape in which threats impact/target the physical, social, economic Genome-wide targeted prediction of ABA responsive genes in rice based on over-represented cis-motif in co-expressed genes. Lenka, Sangram K; Lohia, Bikash; Kumar, Abhay; Chinnusamy, Viswanathan; Bansal, Kailash C Abscisic acid (ABA), the popular plant stress hormone, plays a key role in regulation of sub-set of stress responsive genes. These genes respond to ABA through specific transcription factors which bind to cis-regulatory elements present in their promoters. We discovered the ABA Responsive Element (ABRE) core (ACGT) containing CGMCACGTGB motif as over-represented motif among the promoters of ABA responsive co-expressed genes in rice. Targeted gene prediction strategy using this motif led to the identification of 402 protein coding genes potentially regulated by ABA-dependent molecular genetic network. RT-PCR analysis of arbitrarily chosen 45 genes from the predicted 402 genes confirmed 80% accuracy of our prediction. Plant Gene Ontology (GO) analysis of ABA responsive genes showed enrichment of signal transduction and stress related genes among diverse functional categories. Signal Network Analysis of Plant Genes Responding to Ionizing Radiation Kim, Dong Sub; Kim, Jinbaek; Kim, Sang Hoon In this project, we irradiated Arabidopsis plants with various doses of gamma-rays at the vegetative and reproductive stages to assess their radiation sensitivity. After the gene expression profiles and an analysis of the antioxidant response, we selected several Arabidopsis genes for uses of 'Radio marker genes (RMG)' and conducted over-expression and knock-down experiments to confirm the radio sensitivity. Based on these results, we applied two patents for the detection of two RMG (At3g28210 and At4g37990) and development of transgenic plants. Also, we developed a Genechip for use of high-throughput screening of Arabidopsis genes responding only to ionizing radiation and identified RMG to detect radiation leaks. Based on these results, we applied two patents associated with the use of Genechip for different types of radiation and different growth stages. Also, we conducted co-expression network study of specific expressed probes against gamma-ray stress and identified expressed patterns of duplicated genes formed by whole/500kb segmental genome duplication Structural Analysis of Complex Networks Dehmer, Matthias Filling a gap in literature, this self-contained book presents theoretical and application-oriented results that allow for a structural exploration of complex networks. The work focuses not only on classical graph-theoretic methods, but also demonstrates the usefulness of structural graph theory as a tool for solving interdisciplinary problems. Applications to biology, chemistry, linguistics, and data analysis are emphasized. The book is suitable for a broad, interdisciplinary readership of researchers, practitioners, and graduate students in discrete mathematics, statistics, computer science, Enforcing Co-expression Within a Brain-Imaging Genomics Regression Framework. Zille, Pascal; Calhoun, Vince D; Wang, Yu-Ping Among the challenges arising in brain imaging genetic studies, estimating the potential links between neurological and genetic variability within a population is key. In this work, we propose a multivariate, multimodal formulation for variable selection that leverages co-expression patterns across various data modalities. Our approach is based on an intuitive combination of two widely used statistical models: sparse regression and canonical correlation analysis (CCA). While the former seeks multivariate linear relationships between a given phenotype and associated observations, the latter searches to extract co-expression patterns between sets of variables belonging to different modalities. In the following, we propose to rely on a 'CCA-type' formulation in order to regularize the classical multimodal sparse regression problem (essentially incorporating both CCA and regression models within a unified formulation). The underlying motivation is to extract discriminative variables that are also co-expressed across modalities. We first show that the simplest formulation of such model can be expressed as a special case of collaborative learning methods. After discussing its limitation, we propose an extended, more flexible formulation, and introduce a simple and efficient alternating minimization algorithm to solve the associated optimization problem.We explore the parameter space and provide some guidelines regarding parameter selection. Both the original and extended versions are then compared on a simple toy dataset and a more advanced simulated imaging genomics dataset in order to illustrate the benefits of the latter. Finally, we validate the proposed formulation using single nucleotide polymorphisms (SNP) data and functional magnetic resonance imaging (fMRI) data from a population of adolescents (n = 362 subjects, age 16.9 Â± 1.9 years from the Philadelphia Neurodevelopmental Cohort) for the study of learning ability. Furthermore, we carry out a significance Social Network Analysis and informal trade Walther, Olivier networks can be applied to better understand informal trade in developing countries, with a particular focus on Africa. The paper starts by discussing some of the fundamental concepts developed by social network analysis. Through a number of case studies, we show how social network analysis can...... illuminate the relevant causes of social patterns, the impact of social ties on economic performance, the diffusion of resources and information, and the exercise of power. The paper then examines some of the methodological challenges of social network analysis and how it can be combined with other...... approaches. The paper finally highlights some of the applications of social network analysis and their implications for trade policies.... Analysis of Network Parameters Influencing Performance of Hybrid Multimedia Networks Dominik Kovac Full Text Available Multimedia networks is an emerging subject that currently attracts the attention of research and industrial communities. This environment provides new entertainment services and business opportunities merged with all well-known network services like VoIP calls or file transfers. Such a heterogeneous system has to be able satisfy all network and end-user requirements which are increasing constantly. Therefore the simulation tools enabling deep analysis in order to find the key performance indicators and factors which influence the overall quality for specific network service the most are highly needed. This paper provides a study on the network parameters like communication technology, routing protocol, QoS mechanism, etc. and their effect on the performance of hybrid multimedia network. The analysis was performed in OPNET Modeler environment and the most interesting results are discussed at the end of this paper Functional Module Analysis for Gene Coexpression Networks with Network Integration. Zhang, Shuqin; Zhao, Hongyu; Ng, Michael K Network has been a general tool for studying the complex interactions between different genes, proteins, and other small molecules. Module as a fundamental property of many biological networks has been widely studied and many computational methods have been proposed to identify the modules in an individual network. However, in many cases, a single network is insufficient for module analysis due to the noise in the data or the tuning of parameters when building the biological network. The availability of a large amount of biological networks makes network integration study possible. By integrating such networks, more informative modules for some specific disease can be derived from the networks constructed from different tissues, and consistent factors for different diseases can be inferred. In this paper, we have developed an effective method for module identification from multiple networks under different conditions. The problem is formulated as an optimization model, which combines the module identification in each individual network and alignment of the modules from different networks together. An approximation algorithm based on eigenvector computation is proposed. Our method outperforms the existing methods, especially when the underlying modules in multiple networks are different in simulation studies. We also applied our method to two groups of gene coexpression networks for humans, which include one for three different cancers, and one for three tissues from the morbidly obese patients. We identified 13 modules with three complete subgraphs, and 11 modules with two complete subgraphs, respectively. The modules were validated through Gene Ontology enrichment and KEGG pathway enrichment analysis. We also showed that the main functions of most modules for the corresponding disease have been addressed by other researchers, which may provide the theoretical basis for further studying the modules experimentally. Review Essay: Does Qualitative Network Analysis Exist? Rainer Diaz-Bone Full Text Available Social network analysis was formed and established in the 1970s as a way of analyzing systems of social relations. In this review the theoretical-methodological standpoint of social network analysis ("structural analysis" is introduced and the different forms of social network analysis are presented. Structural analysis argues that social actors and social relations are embedded in social networks, meaning that action and perception of actors as well as the performance of social relations are influenced by the network structure. Since the 1990s structural analysis has integrated concepts such as agency, discourse and symbolic orientation and in this way structural analysis has opened itself. Since then there has been increasing use of qualitative methods in network analysis. They are used to include the perspective of the analyzed actors, to explore networks, and to understand network dynamics. In the reviewed book, edited by Betina HOLLSTEIN and Florian STRAUS, the twenty predominantly empirically orientated contributions demonstrate the possibilities of combining quantitative and qualitative methods in network analyses in different research fields. In this review we examine how the contributions succeed in applying and developing the structural analysis perspective, and the self-positioning of "qualitative network analysis" is evaluated. URN: urn:nbn:de:0114-fqs0701287 Google matrix analysis of directed networks Ermann, Leonardo; Frahm, Klaus M.; Shepelyansky, Dima L. In the past decade modern societies have developed enormous communication and social networks. Their classification and information retrieval processing has become a formidable task for the society. Because of the rapid growth of the World Wide Web, and social and communication networks, new mathematical methods have been invented to characterize the properties of these networks in a more detailed and precise way. Various search engines extensively use such methods. It is highly important to develop new tools to classify and rank a massive amount of network information in a way that is adapted to internal network structures and characteristics. This review describes the Google matrix analysis of directed complex networks demonstrating its efficiency using various examples including the World Wide Web, Wikipedia, software architectures, world trade, social and citation networks, brain neural networks, DNA sequences, and Ulam networks. The analytical and numerical matrix methods used in this analysis originate from the fields of Markov chains, quantum chaos, and random matrix theory. Capacity Analysis of Wireless Mesh Networks M. I. Gumel Full Text Available The next generation wireless networks experienced a great development with emergence of wireless mesh networks (WMNs, which can be regarded as a realistic solution that provides wireless broadband access. The limited available bandwidth makes capacity analysis of the network very essential. While the network offers broadband wireless access to community and enterprise users, the problems that limit the network capacity must be addressed to exploit the optimum network performance. The wireless mesh network capacity analysis shows that the throughput of each mesh node degrades in order of l/n with increasing number of nodes (n in a linear topology. The degradation is found to be higher in a fully mesh network as a result of increase in interference and MAC layer contention in the network. S187. SEARCHING FOR BRAIN CO-EXPRESSION MODULES THAT CONTRIBUTE DISPROPORTIONATELY TO THE COMMON POLYGENIC RISK FOR SCHIZOPHRENIA Costas, Javier; Paramo, Mario; Arrojo, Manuel Abstract Background Genomic research has revealed that schizophrenia is a highly polygenic disease. Recent estimates indicate that at least 71% of genomic segments of 1 Mb include one or more risk loci for schizophrenia (Loh et al., Nature Genet 2015). This extremely high polygenicity represents a challenge to decipher the biological basis of schizophrenia, as it is expected that any set of SNPs with enough size will be associated with the disorder. Among the different gene sets available for study (such as those from Gene Ontology, KEGG pathway, Reactome pathways or protein protein interaction datasets), those based on brain co-expression networks represent putative functional relationships in the relevant tissue. The aim of this work was to identify brain co-expression networks that contribute disproportionately to the common polygenic risk for schizophrenia to get more insight on schizophrenia etiopathology. Methods We analyzed a case -control dataset consisting of 582 schizophrenia patients from Galicia, NW Spain, and 591 ancestrally matched controls, genotyped with the Illumina PsychArray. Using as discovery sample the summary results from the largest GWAS of schizophrenia to date (Psychiatric Genomics Consortium, SCZ2), we generated polygenic risk scores (PRS) in our sample based on SNPs located at genes belonging to brain co-expression modules determined by the CommonMind Consortium (Fromer et al., Nature Neurosci 2016). PRS were generated using the clumping procedure of PLINK, considering several different thresholds to select SNPs from the discovery sample. In order to test if any specific module increased risk to schizophrenia more than expected by their size, we generated up to 10,000 random permutations of the same number of SNPs, matched by frequency, distance to nearest gene, number of SNPs in LD and gene density, using SNPsnap. Results As expected, most modules with enough number of independent SNPs belonging to them showed a significant increase in Social network analysis community detection and evolution Missaoui, Rokia This book is devoted to recent progress in social network analysis with a high focus on community detection and evolution. The eleven chapters cover the identification of cohesive groups, core components and key players either in static or dynamic networks of different kinds and levels of heterogeneity. Other important topics in social network analysis such as influential detection and maximization, information propagation, user behavior analysis, as well as network modeling and visualization are also presented. Many studies are validated through real social networks such as Twitter. This edit Network analysis literacy a practical approach to the analysis of networks Zweig, Katharina A Network Analysis Literacy focuses on design principles for network analytics projects. The text enables readers to: pose a defined network analytic question; build a network to answer the question; choose or design the right network analytic methods for a particular purpose, and more. Networks and Bargaining in Policy Analysis Bogason, Peter A duscussion of the fight between proponents of rationalistic policy analysis and more political interaction models for policy analysis. The latter group is the foundation for the many network models of policy analysis of today.......A duscussion of the fight between proponents of rationalistic policy analysis and more political interaction models for policy analysis. The latter group is the foundation for the many network models of policy analysis of today.... Analysis of Recurrent Analog Neural Networks Z. Raida Full Text Available In this paper, an original rigorous analysis of recurrent analog neural networks, which are built from opamp neurons, is presented. The analysis, which comes from the approximate model of the operational amplifier, reveals causes of possible non-stable states and enables to determine convergence properties of the network. Results of the analysis are discussed in order to enable development of original robust and fast analog networks. In the analysis, the special attention is turned to the examination of the influence of real circuit elements and of the statistical parameters of processed signals to the parameters of the network. Transcriptional Regulatory Network Analysis of MYB Transcription Factor Family Genes in Rice Shuchi eSmita Full Text Available MYB transcription factor (TF is one of the largest TF families and regulates defense responses to various stresses, hormone signaling as well as many metabolic and developmental processes in plants. Understanding these regulatory hierarchies of gene expression networks in response to developmental and environmental cues is a major challenge due to the complex interactions between the genetic elements. Correlation analyses are useful to unravel co-regulated gene pairs governing biological process as well as identification of new candidate hub genes in response to these complex processes. High throughput expression profiling data are highly useful for construction of co-expression networks. In the present study, we utilized transcriptome data for comprehensive regulatory network studies of MYB TFs by top down and guide gene approaches. More than 50% of OsMYBs were strongly correlated under fifty experimental conditions with 51 hub genes via top down approach. Further, clusters were identified using Markov Clustering (MCL. To maximize the clustering performance, parameter evaluation of the MCL inflation score (I was performed in terms of enriched GO categories by measuring F-score. Comparison of co-expressed cluster and clads analyzed from phylogenetic analysis signifies their evolutionarily conserved co-regulatory role. We utilized compendium of known interaction and biological role with Gene Ontology enrichment analysis to hypothesize function of coexpressed OsMYBs. In the other part, the transcriptional regulatory network analysis by guide gene approach revealed 40 putative targets of 26 OsMYB TF hubs with high correlation value utilizing 815 microarray data. The putative targets with MYB-binding cis-elements enrichment in their promoter region, functional co-occurrence as well as nuclear localization supports our finding. Specially, enrichment of MYB binding regions involved in drought-inducibility implying their regulatory role in drought Egocentric Social Network Analysis of Pathological Gambling Meisel, Matthew K.; Clifton, Allan D.; MacKillop, James; Miller, Joshua D.; Campbell, W. Keith; Goodie, Adam S. Aims To apply social network analysis (SNA) to investigate whether frequency and severity of gambling problems were associated with different network characteristics among friends, family, and co-workers. is an innovative way to look at relationships among individuals; the current study was the first to our knowledge to apply SNA to gambling behaviors. Design Egocentric social network analysis was used to formally characterize the relationships between social network characteristics and gambling pathology. Setting Laboratory-based questionnaire and interview administration. Participants Forty frequent gamblers (22 non-pathological gamblers, 18 pathological gamblers) were recruited from the community. Findings The SNA revealed significant social network compositional differences between the two groups: pathological gamblers (PGs) had more gamblers, smokers, and drinkers in their social networks than did nonpathological gamblers (NPGs). PGs had more individuals in their network with whom they personally gambled, smoked, and drank with than those with who were NPG. Network ties were closer to individuals in their networks who gambled, smoked, and drank more frequently. Associations between gambling severity and structural network characteristics were not significant. Conclusions Pathological gambling is associated with compositional but not structural differences in social networks. Pathological gamblers differ from non-pathological gamblers in the number of gamblers, smokers, and drinkers in their social networks. Homophily within the networks also indicates that gamblers tend to be closer with other gamblers. This homophily may serve to reinforce addictive behaviors, and may suggest avenues for future study or intervention. PMID:23072641 Egocentric social network analysis of pathological gambling. Meisel, Matthew K; Clifton, Allan D; Mackillop, James; Miller, Joshua D; Campbell, W Keith; Goodie, Adam S To apply social network analysis (SNA) to investigate whether frequency and severity of gambling problems were associated with different network characteristics among friends, family and co-workers is an innovative way to look at relationships among individuals; the current study was the first, to our knowledge, to apply SNA to gambling behaviors. Egocentric social network analysis was used to characterize formally the relationships between social network characteristics and gambling pathology. Laboratory-based questionnaire and interview administration. Forty frequent gamblers (22 non-pathological gamblers, 18 pathological gamblers) were recruited from the community. The SNA revealed significant social network compositional differences between the two groups: pathological gamblers (PGs) had more gamblers, smokers and drinkers in their social networks than did non-pathological gamblers (NPGs). PGs had more individuals in their network with whom they personally gambled, smoked and drank than those with who were NPG. Network ties were closer to individuals in their networks who gambled, smoked and drank more frequently. Associations between gambling severity and structural network characteristics were not significant. Pathological gambling is associated with compositional but not structural differences in social networks. Pathological gamblers differ from non-pathological gamblers in the number of gamblers, smokers and drinkers in their social networks. Homophily within the networks also indicates that gamblers tend to be closer with other gamblers. This homophily may serve to reinforce addictive behaviors, and may suggest avenues for future study or intervention. Â© 2012 The Authors, Addiction Â© 2012 Society for the Study of Addiction. Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes Paules Richard S Full Text Available Abstract Background A common observation in the analysis of gene expression data is that many genes display similarity in their expression patterns and therefore appear to be co-regulated. However, the variation associated with microarray data and the complexity of the experimental designs make the acquisition of co-expressed genes a challenge. We developed a novel method for Extracting microarray gene expression Patterns and Identifying co-expressed Genes, designated as EPIG. The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions. Results Through evaluation of the correlations among profiles, the magnitude of variation in gene expression profiles, and profile signal-to-noise ratio's, EPIG extracts a set of patterns representing co-expressed genes. The method is shown to work well with a simulated data set and microarray data obtained from time-series studies of dauer recovery and L1 starvation in C. elegans and after ultraviolet (UV or ionizing radiation (IR-induced DNA damage in diploid human fibroblasts. With the simulated data set, EPIG extracted the appropriate number of patterns which were more stable and homogeneous than the set of patterns that were determined using the CLICK or CAST clustering algorithms. However, CLICK performed better than EPIG and CAST with respect to the average correlation between clusters/patterns of the simulated data. With real biological data, EPIG extracted more dauer-specific patterns than CLICK. Furthermore, analysis of the IR/UV data revealed 18 unique patterns and 2661 genes out of approximately 17,000 that were identified as significantly expressed and categorized to the patterns by EPIG. The time-dependent patterns displayed similar and dissimilar responses between IR and UV treatments. Gene Ontology analysis applied to each pattern-related subset of co-expressed genes revealed underlying Social network analysis and supply chain management RaÃºl RodrÃguez RodrÃguez Full Text Available This paper deals with social network analysis and how it could be integrated within supply chain management from a decision-making point of view. Even though the benefits of using social analysis have are widely accepted at both academic and industry/services context, there is still a lack of solid frameworks that allow decision-makers to connect the usage and obtained results of social network analysis â€“ mainly both information and knowledge flows and derived results- with supply chain management objectives and goals. This paper gives an overview of social network analysis, the main social network analysis metrics, supply chain performance and, finally, it identifies how future frameworks could close the gap and link the results of social network analysis with the supply chain management decision-making processes. The Network Protocol Analysis Technique in Snort Wu, Qing-Xiu Network protocol analysis is a network sniffer to capture data for further analysis and understanding of the technical means necessary packets. Network sniffing is intercepted by packet assembly binary format of the original message content. In order to obtain the information contained. Required based on TCP / IP protocol stack protocol specification. Again to restore the data packets at protocol format and content in each protocol layer. Actual data transferred, as well as the application tier. Ecological network analysis for a virtual water network. Fang, Delin; Chen, Bin The notions of virtual water flows provide important indicators to manifest the water consumption and allocation between different sectors via product transactions. However, the configuration of virtual water network (VWN) still needs further investigation to identify the water interdependency among different sectors as well as the network efficiency and stability in a socio-economic system. Ecological network analysis is chosen as a useful tool to examine the structure and function of VWN and the interactions among its sectors. A balance analysis of efficiency and redundancy is also conducted to describe the robustness (RVWN) of VWN. Then, network control analysis and network utility analysis are performed to investigate the dominant sectors and pathways for virtual water circulation and the mutual relationships between pairwise sectors. A case study of the Heihe River Basin in China shows that the balance between efficiency and redundancy is situated on the left side of the robustness curve with less efficiency and higher redundancy. The forestation, herding and fishing sectors and industrial sectors are found to be the main controllers. The network tends to be more mutualistic and synergic, though some competitive relationships that weaken the virtual water circulation still exist. Basic general concepts in the network analysis Boja Nicolae Full Text Available This survey is concerned oneself with the study of those types of material networks which can be met both in civil engineering and also in electrotechnics, in mechanics, or in hydrotechnics, and of which behavior lead to linear problems, solvable by means of Finite Element Method and adequate algorithms. Here, it is presented a unitary theory of networks met in the domains mentioned above and this one is illustrated with examples for the structural networks in civil engineering, electric circuits, and water supply networks, but also planar or spatial mechanisms can be comprised in this theory. The attention is focused to make evident the essential proper- ties and concepts in the network analysis, which differentiate the networks under force from other types of material networks. To such a network a planar, connected, and directed or undirected graph is associated, and with some vector fields on the vertex set this graph is endowed. . Network Analysis on Attitudes: A Brief Tutorial. Dalege, Jonas; Borsboom, Denny; van Harreveld, Frenk; van der Maas, Han L J In this article, we provide a brief tutorial on the estimation, analysis, and simulation on attitude networks using the programming language R. We first discuss what a network is and subsequently show how one can estimate a regularized network on typical attitude data. For this, we use open-access data on the attitudes toward Barack Obama during the 2012 American presidential election. Second, we show how one can calculate standard network measures such as community structure, centrality, and connectivity on this estimated attitude network. Third, we show how one can simulate from an estimated attitude network to derive predictions from attitude networks. By this, we highlight that network theory provides a framework for both testing and developing formalized hypotheses on attitudes and related core social psychological constructs. 4th International Conference in Network Analysis Koldanov, Petr; Pardalos, Panos The contributions in this volume cover a broad range of topics including maximum cliques, graph coloring, data mining, brain networks, Steiner forest, logistic and supply chain networks. Network algorithms and their applications to market graphs, manufacturing problems, internet networks and social networks are highlighted. The "Fourth International Conference in Network Analysis," held at the Higher School of Economics, Nizhny Novgorod in May 2014, initiated joint research between scientists, engineers and researchers from academia, industry and government; the major results of conference participants have been reviewed and collected in this Work. Researchers and students in mathematics, economics, statistics, computer science and engineering will find this collection a valuable resource filled with the latest research in network analysis. An investigation and comparison on network performance analysis Lanxiaopu, Mi This thesis is generally about network performance analysis. It contains two parts. The theory part summarizes what network performance is and inducts the methods of doing network performance analysis. To answer what network performance is, a study into what network services are is done. And based on the background research, there are two important network performance metrics: Network delay and Throughput should be included in network performance analysis. Among the methods of network a... Investigating biofuels through network analysis Curci, Ylenia; Mongeau Ospina, Christian A. Biofuel policies are motivated by a plethora of political concerns related to energy security, environmental damages, and support of the agricultural sector. In response to this, much scientific work has chiefly focussed on analysing the biofuel domain and on giving policy advice and recommendations. Although innovation has been acknowledged as one of the key factors in sustainable and cost-effective biofuel development, there is an urgent need to investigate technological trajectories in the biofuel sector by starting from consistent data and appropriate methodological tools. To do so, this work proposes a procedure to select patent data unequivocally related to the investigated sector, it uses co-occurrence of technological terms to compute patent similarity and highlights content and interdependencies of biofuels technological trajectories by revealing hidden topics from unstructured patent text fields. The analysis suggests that there is a breaking trend towards modern generation biofuels and that innovators seem to focus increasingly on the ability of alternative energy sources to adapt to the transport/industrial sector. - Highlights: â€¢ Innovative effort is devoted to biofuels additives and modern biofuels technologies. â€¢ A breaking trend can be observed from the second half of the last decade. â€¢ A patent network is identified via text mining techniques that extract latent topics. Weighted Complex Network Analysis of Pakistan Highways Yasir Tariq Mohmand Full Text Available The structure and properties of public transportation networks have great implications in urban planning, public policies, and infectious disease control. This study contributes a weighted complex network analysis of travel routes on the national highway network of Pakistan. The network is responsible for handling 75 percent of the road traffic yet is largely inadequate, poor, and unreliable. The highway network displays small world properties and is assortative in nature. Based on the betweenness centrality of the nodes, the most important cities are identified as this could help in identifying the potential congestion points in the network. Keeping in view the strategic location of Pakistan, such a study is of practical importance and could provide opportunities for policy makers to improve the performance of the highway network. Noise Analysis studies with neural networks Seker, S.; Ciftcioglu, O. Noise analysis studies with neural network are aimed. Stochastic signals at the input of the network are used to obtain an algorithmic multivariate stochastic signal modeling. To this end, lattice modeling of a stochastic signal is performed to obtain backward residual noise sources which are uncorrelated among themselves. There are applied together with an additional input to the network to obtain an algorithmic model which is used for signal detection for early failure in plant monitoring. The additional input provides the information to the network to minimize the difference between the signal and the network's one-step-ahead prediction. A stochastic algorithm is used for training where the errors reflecting the measurement error during the training are also modelled so that fast and consistent convergence of network's weights is obtained. The lattice structure coupled to neural network investigated with measured signals from an actual power plant. (authors) Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes. Chen, Juan; Xu, Juan; Li, Yongsheng; Zhang, Jinwen; Chen, Hong; Lu, Jianping; Wang, Zishan; Zhao, Xueying; Xu, Kang; Li, Yixue; Li, Xia; Zhang, Yan Although competing endogenous RNAs (ceRNAs) have been implicated in many solid tumors, their roles in breast cancer subtypes are not well understood. We therefore generated a ceRNA network for each subtype based on the significance of both, positive co-expression and the shared miRNAs, in the corresponding subtype miRNA dys-regulatory network, which was constructed based on negative regulations between differentially expressed miRNAs and targets. All four subtype ceRNA networks exhibited scale-free architecture and showed that the common ceRNAs were at the core of the networks. Furthermore, the common ceRNA hubs had greater connectivity than the subtype-specific hubs. Functional analysis of the common subtype ceRNA hubs highlighted factors involved in proliferation, MAPK signaling pathways and tube morphogenesis. Subtype-specific ceRNA hubs highlighted unique subtype-specific pathways, like the estrogen response and inflammatory pathways in the luminal subtypes or the factors involved in the coagulation process that participates in the basal-like subtype. Ultimately, we identified 29 critical subtype-specific ceRNA hubs that characterized the different breast cancer subtypes. Our study thus provides new insight into the common and specific subtype ceRNA interactions that define the different categories of breast cancer and enhances our understanding of the pathology underlying the different breast cancer subtypes, which can have prognostic and therapeutic implications in the future. Classification and Analysis of Computer Network Traffic Bujlow, Tomasz Traffic monitoring and analysis can be done for multiple different reasons: to investigate the usage of network resources, assess the performance of network applications, adjust Quality of Service (QoS) policies in the network, log the traffic to comply with the law, or create realistic models of traffic for academic purposes. We define the objective of this thesis as finding a way to evaluate the performance of various applications in a high-speed Internet infrastructure. To satisfy the obje... Wireless Sensor Network Security Analysis Hemanta Kumar Kalita; Avijit Kar The emergence of sensor networks as one of the dominant technology trends in the coming decades hasposed numerous unique challenges to researchers. These networks are likely to be composed of hundreds,and potentially thousands of tiny sensor nodes, functioning autonomously, and in many cases, withoutaccess to renewable energy resources. Cost constraints and the need for ubiquitous, invisibledeployments will result in small sized, resource-constrained sensor nodes. While the set of challenges ... Industrial entrepreneurial network: Structural and functional analysis Medvedeva, M. A.; Davletbaev, R. H.; Berg, D. B.; Nazarova, J. J.; Parusheva, S. S. Structure and functioning of two model industrial entrepreneurial networks are investigated in the present paper. One of these networks is forming when implementing an integrated project and consists of eight agents, which interact with each other and external environment. The other one is obtained from the municipal economy and is based on the set of the 12 real business entities. Analysis of the networks is carried out on the basis of the matrix of mutual payments aggregated over the certain time period. The matrix is created by the methods of experimental economics. Social Network Analysis (SNA) methods and instruments were used in the present research. The set of basic structural characteristics was investigated: set of quantitative parameters such as density, diameter, clustering coefficient, different kinds of centrality, and etc. They were compared with the random Bernoulli graphs of the corresponding size and density. Discovered variations of random and entrepreneurial networks structure are explained by the peculiarities of agents functioning in production network. Separately, were identified the closed exchange circuits (cyclically closed contours of graph) forming an autopoietic (self-replicating) network pattern. The purpose of the functional analysis was to identify the contribution of the autopoietic network pattern in its gross product. It was found that the magnitude of this contribution is more than 20%. Such value allows using of the complementary currency in order to stimulate economic activity of network agents. 3rd International Conference on Network Analysis Kalyagin, Valery; Pardalos, Panos This volume compiles the major results of conference participants from the "Third International Conference in Network Analysis" held at the Higher School of Economics, Nizhny Novgorod in May 2013, with the aim to initiate further joint research among different groups. The contributions in this book cover a broad range of topics relevant to the theory and practice of network analysis, including the reliability of complex networks, software, theory, methodology, and applications. Â Network analysis has become a major research topic over the last several years. The broad range of applications that can be described and analyzed by means of a network has brought together researchers, practitioners from numerous fields such as operations research, computer science, transportation, energy, biomedicine, computational neuroscience and social sciences. In addition, new approaches and computer environments such as parallel computing, grid computing, cloud computing, and quantum computing have helped to solve large scale... Custom Ontologies for Expanded Network Analysis for Expanded Network Analysis. In Visualising Network Information (pp. 6-1 â€“ 6-10). Meeting Proceedings RTO-MP-IST-063, Paper 6. Neuilly-sur-Seine...Even to this day, current research groups are working to develop an approach that involves taking all available text, video, imagery and audio and Analysis of complex networks using aggressive abstraction. Colbaugh, Richard; Glass, Kristin.; Willard, Gerald This paper presents a new methodology for analyzing complex networks in which the network of interest is first abstracted to a much simpler (but equivalent) representation, the required analysis is performed using the abstraction, and analytic conclusions are then mapped back to the original network and interpreted there. We begin by identifying a broad and important class of complex networks which admit abstractions that are simultaneously dramatically simplifying and property preserving we call these aggressive abstractions -- and which can therefore be analyzed using the proposed approach. We then introduce and develop two forms of aggressive abstraction: 1.) finite state abstraction, in which dynamical networks with uncountable state spaces are modeled using finite state systems, and 2.) onedimensional abstraction, whereby high dimensional network dynamics are captured in a meaningful way using a single scalar variable. In each case, the property preserving nature of the abstraction process is rigorously established and efficient algorithms are presented for computing the abstraction. The considerable potential of the proposed approach to complex networks analysis is illustrated through case studies involving vulnerability analysis of technological networks and predictive analysis for social processes. Consistency analysis of network traffic repositories Lastdrager, Elmer; Lastdrager, E.E.H.; Pras, Aiko Traffic repositories with TCP/IP header information are very important for network analysis. Researchers often assume that such repositories reliably represent all traffic that has been flowing over the network; little thoughts are made regarding the consistency of these repositories. Still, for Boolean Factor Analysis by Attractor Neural Network Frolov, A. A.; HÃºsek, DuÅ¡an; Muraviev, I. P.; Polyakov, P.Y. RoÄ�. 18, Ä�. 3 (2007), s. 698-707 ISSN 1045-9227 R&D Projects: GA AV ÄŒR 1ET100300419; GA ÄŒR GA201/05/0079 Institutional research plan: CEZ:AV0Z10300504 Keywords : recurrent neural network * Hopfield-like neural network * associative memory * unsupervised learning * neural network architecture * neural network application * statistics * Boolean factor analysis * dimensionality reduction * features clustering * concepts search * information retrieval Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 2.769, year: 2007 Spectrum-Based and Collaborative Network Topology Analysis and Visualization Hu, Xianlin Networks are of significant importance in many application domains, such as World Wide Web and social networks, which often embed rich topological information. Since network topology captures the organization of network nodes and links, studying network topology is very important to network analysis. In this dissertation, we study networks byâ€¦ Analysis and Testing of Mobile Wireless Networks Alena, Richard; Evenson, Darin; Rundquist, Victor; Clancy, Daniel (Technical Monitor) Wireless networks are being used to connect mobile computing elements in more applications as the technology matures. There are now many products (such as 802.11 and 802.11b) which ran in the ISM frequency band and comply with wireless network standards. They are being used increasingly to link mobile Intranet into Wired networks. Standard methods of analyzing and testing their performance and compatibility are needed to determine the limits of the technology. This paper presents analytical and experimental methods of determining network throughput, range and coverage, and interference sources. Both radio frequency (BE) domain and network domain analysis have been applied to determine wireless network throughput and range in the outdoor environment- Comparison of field test data taken under optimal conditions, with performance predicted from RF analysis, yielded quantitative results applicable to future designs. Layering multiple wireless network- sooners can increase performance. Wireless network components can be set to different radio frequency-hopping sequences or spreading functions, allowing more than one sooner to coexist. Therefore, we ran multiple 802.11-compliant systems concurrently in the same geographical area to determine interference effects and scalability, The results can be used to design of more robust networks which have multiple layers of wireless data communication paths and provide increased throughput overall. Full Text Available The structure and properties of public transportation networks can provide suggestions for urban planning and public policies. This study contributes a complex network analysis of the Guangzhou metro. The metro network has 236 kilometers of track and is the 6th busiest metro system of the world. In this paper topological properties of the network are explored. We observed that the network displays small world properties and is assortative in nature. The network possesses a high average degree of 17.5 with a small diameter of 5. Furthermore, we also identified the most important metro stations based on betweenness and closeness centralities. These could help in identifying the probable congestion points in the metro system and provide policy makers with an opportunity to improve the performance of the metro system. Extending Stochastic Network Calculus to Loss Analysis Chao Luo Full Text Available Loss is an important parameter of Quality of Service (QoS. Though stochastic network calculus is a very useful tool for performance evaluation of computer networks, existing studies on stochastic service guarantees mainly focused on the delay and backlog. Some efforts have been made to analyse loss by deterministic network calculus, but there are few results to extend stochastic network calculus for loss analysis. In this paper, we introduce a new parameter named loss factor into stochastic network calculus and then derive the loss bound through the existing arrival curve and service curve via this parameter. We then prove that our result is suitable for the networks with multiple input flows. Simulations show the impact of buffer size, arrival traffic, and service on the loss factor. Computer network environment planning and analysis Dalphin, John F. The GSFC Computer Network Environment provides a broadband RF cable between campus buildings and ethernet spines in buildings for the interlinking of Local Area Networks (LANs). This system provides terminal and computer linkage among host and user systems thereby providing E-mail services, file exchange capability, and certain distributed computing opportunities. The Environment is designed to be transparent and supports multiple protocols. Networking at Goddard has a short history and has been under coordinated control of a Network Steering Committee for slightly more than two years; network growth has been rapid with more than 1500 nodes currently addressed and greater expansion expected. A new RF cable system with a different topology is being installed during summer 1989; consideration of a fiber optics system for the future will begin soon. Summmer study was directed toward Network Steering Committee operation and planning plus consideration of Center Network Environment analysis and modeling. Biweekly Steering Committee meetings were attended to learn the background of the network and the concerns of those managing it. Suggestions for historical data gathering have been made to support future planning and modeling. Data Systems Dynamic Simulator, a simulation package developed at NASA and maintained at GSFC was studied as a possible modeling tool for the network environment. A modeling concept based on a hierarchical model was hypothesized for further development. Such a model would allow input of newly updated parameters and would provide an estimation of the behavior of the network. UMA/GAN network architecture analysis Yang, Liang; Li, Wensheng; Deng, Chunjian; Lv, Yi This paper is to critically analyze the architecture of UMA which is one of Fix Mobile Convergence (FMC) solutions, and also included by the third generation partnership project(3GPP). In UMA/GAN network architecture, UMA Network Controller (UNC) is the key equipment which connects with cellular core network and mobile station (MS). UMA network could be easily integrated into the existing cellular networks without influencing mobile core network, and could provides high-quality mobile services with preferentially priced indoor voice and data usage. This helps to improve subscriber's experience. On the other hand, UMA/GAN architecture helps to integrate other radio technique into cellular network which includes WiFi, Bluetooth, and WiMax and so on. This offers the traditional mobile operators an opportunity to integrate WiMax technique into cellular network. In the end of this article, we also give an analysis of potential influence on the cellular core networks ,which is pulled by UMA network. Constructing an Intelligent Patent Network Analysis Method Chao-Chan Wu Full Text Available Patent network analysis, an advanced method of patent analysis, is a useful tool for technology management. This method visually displays all the relationships among the patents and enables the analysts to intuitively comprehend the overview of a set of patents in the field of the technology being studied. Although patent network analysis possesses relative advantages different from traditional methods of patent analysis, it is subject to several crucial limitations. To overcome the drawbacks of the current method, this study proposes a novel patent analysis method, called the intelligent patent network analysis method, to make a visual network with great precision. Based on artificial intelligence techniques, the proposed method provides an automated procedure for searching patent documents, extracting patent keywords, and determining the weight of each patent keyword in order to generate a sophisticated visualization of the patent network. This study proposes a detailed procedure for generating an intelligent patent network that is helpful for improving the efficiency and quality of patent analysis. Furthermore, patents in the field of Carbon Nanotube Backlight Unit (CNT-BLU were analyzed to verify the utility of the proposed method. Techniques for Intelligence Analysis of Networks National Research Council Canada - National Science Library Cares, Jeffrey R ...) there are significant intelligence analysis manifestations of these properties; and (4) a more satisfying theory of Networked Competition than currently exists for NCW/NCO is emerging from this research... Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer Yuan NJ Full Text Available Naijun Yuan,1,* Guijuan Zhang,2,* Fengjie Bie,1 Min Ma,1 Yi Ma,3 Xuefeng Jiang,1 Yurong Wang,1,* Xiaoqian Hao1 1College of Traditional Chinese Medicine of Jinan University, Institute of Integrated Traditional Chinese and Western Medicine of Jinan University, 2The First Affiliated Hospital of Jinan University, 3Department of Cellular Biology, Guangdong Province Key Lab of Bioengineering Medicine, Institute of Biomedicine, Jinan University, Guangdong, China These authors contributed equally to this work Abstract: Triple negative breast cancer (TNBC is a particular subtype of breast malignant tumor with poorer prognosis than other molecular subtypes. Currently, there is increasing focus on long non-coding RNAs (lncRNAs, which can act as competing endogenous RNAs (ceRNAs and suppress miRNA functions involved in post-transcriptional regulatory networks in the tumor. Therefore, to investigate specific mechanisms of TNBC carcinogenesis and improve treatment efficiency, we comprehensively integrated expression profiles, including data on mRNAs, lncRNAs and miRNAs obtained from 116 TNBC tissues and 11 normal tissues from The Cancer Genome Atlas. As a result, we selected the threshold with \|log2FC\|>2.0 and an adjusted p-value >0.05 to obtain the differentially expressed mRNAs, miRNAs and lncRNAs. Hereafter, weighted gene co-expression network analysis was performed to identify the expression characteristics of dysregulated genes. We obtained five co-expression modules and related clinical feature. By means of correlating gene modules with proteinâ€“protein interaction network analysis that had identified 22 hub mRNAs which could as hub target genes. Eleven key dysregulated differentially expressed micro RNAs (DEmiRNAs were identified that were significantly associated with the 22 hub potential target genes. Moreover, we found that 14 key differentially expressed lncRNAs could interact with the key DEmiRNAs. Then, the ceRNA crosstalk network of TNBC was Topological Analysis of Wireless Networks (TAWN) 19b. TELEPHONE NUMBER (Include area code) 31-05-2016 FINAL REPORT 12-02-2015 -- 31-05-2016 Topological Analysis of Wireless Networks (TAWN) Robinson...Release, Distribution Unlimited) N/A The goal of this project was to develop topological methods to detect and localize vulnerabilities of wireless... topology U U U UU 32 Michael Robinson 202-885-3681 Final Report: May 2016 Topological Analysis of Wireless Networks Principal Investigator: Prof. Michael Analysis of FOXO transcriptional networks van der Vos, K.E. The PI3K-PKB-FOXO signalling module plays a pivotal role in a wide variety of cellular processes, including proliferation, survival, differentiation and metabolism. Inappropriate activation of this network is frequently observed in human cancer and causes uncontrolled proliferation and survival. In 1st International Conference on Network Analysis This volume contains a selection of contributions from the "First International Conference in Network Analysis," held at the University of Florida, Gainesville, on December 14-16, 2011. The remarkable diversity of fields that take advantage of Network Analysis makes the endeavor of gathering up-to-date material in a single compilation a useful, yet very difficult, task. The purpose of this volume is to overcome this difficulty by collecting the major results found by the participants and combining them in one easily accessible compilation. Network analysis has become a major research topic over the last several years. The broad range of applications that can be described and analyzed by means of a network is bringing together researchers, practitioners and other scientific communities from numerous fields such as Operations Research, Computer Science, Transportation, Energy, Social Sciences, and more. The contributions not only come from different fields, but also cover a broad range of topics relevant to the... Artificial neural networks for plasma spectroscopy analysis Morgan, W.L.; Larsen, J.T.; Goldstein, W.H. Artificial neural networks have been applied to a variety of signal processing and image recognition problems. Of the several common neural models the feed-forward, back-propagation network is well suited for the analysis of scientific laboratory data, which can be viewed as a pattern recognition problem. The authors present a discussion of the basic neural network concepts and illustrate its potential for analysis of experiments by applying it to the spectra of laser produced plasmas in order to obtain estimates of electron temperatures and densities. Although these are high temperature and density plasmas, the neural network technique may be of interest in the analysis of the low temperature and density plasmas characteristic of experiments and devices in gaseous electronics Visualization and Analysis of Complex Covert Networks Memon, Bisharat systems that are covert and hence inherently complex. My Ph.D. is positioned within the wider framework of CrimeFighter project. The framework envisions a number of key knowledge management processes that are involved in the workflow, and the toolbox provides supporting tools to assist human end......This report discusses and summarize the results of my work so far in relation to my Ph.D. project entitled "Visualization and Analysis of Complex Covert Networks". The focus of my research is primarily on development of methods and supporting tools for visualization and analysis of networked......-users (intelligence analysts) in harvesting, filtering, storing, managing, structuring, mining, analyzing, interpreting, and visualizing data about offensive networks. The methods and tools proposed and discussed in this work can also be applied to analysis of more generic complex networks.... Historical Network Analysis of the Web BrÃ¼gger, Niels This article discusses some of the fundamental methodological challenges related to doing historical network analyses of the web based on material in web archives. Since the late 1990s many countries have established extensive national web archives, and software supported network analysis...... of the online web has for a number of years gained currency within Internet studies. However, the combination of these two phenomenaâ€”historical network analysis of material in web archivesâ€”can at best be characterized as an emerging new area of study. Most of the methodological challenges within this new area...... revolve around the specific nature of archived web material. On the basis of an introduction to the processes involved in web archiving as well as of the characteristics of archived web material, the article outlines and scrutinizes some of the major challenges which may arise when doing network analysis... The International Trade Network: weighted network analysis and modelling Bhattacharya, K; Mukherjee, G; Manna, S S; SaramÃ¤ki, J; Kaski, K Tools of the theory of critical phenomena, namely the scaling analysis and universality, are argued to be applicable to large complex web-like network structures. Using a detailed analysis of the real data of the International Trade Network we argue that the scaled link weight distribution has an approximate log-normal distribution which remains robust over a period of 53 years. Another universal feature is observed in the power-law growth of the trade strength with gross domestic product, the exponent being similar for all countries. Using the 'rich-club' coefficient measure of the weighted networks it has been shown that the size of the rich-club controlling half of the world's trade is actually shrinking. While the gravity law is known to describe well the social interactions in the static networks of population migration, international trade, etc, here for the first time we studied a non-conservative dynamical model based on the gravity law which excellently reproduced many empirical features of the ITN Network Anomaly Detection Based on Wavelet Analysis Ali A. Ghorbani Full Text Available Signal processing techniques have been applied recently for analyzing and detecting network anomalies due to their potential to find novel or unknown intrusions. In this paper, we propose a new network signal modelling technique for detecting network anomalies, combining the wavelet approximation and system identification theory. In order to characterize network traffic behaviors, we present fifteen features and use them as the input signals in our system. We then evaluate our approach with the 1999 DARPA intrusion detection dataset and conduct a comprehensive analysis of the intrusions in the dataset. Evaluation results show that the approach achieves high-detection rates in terms of both attack instances and attack types. Furthermore, we conduct a full day's evaluation in a real large-scale WiFi ISP network where five attack types are successfully detected from over 30 millions flows. Lu, Wei; Ghorbani, Ali A. Signal processing techniques have been applied recently for analyzing and detecting network anomalies due to their potential to find novel or unknown intrusions. In this paper, we propose a new network signal modelling technique for detecting network anomalies, combining the wavelet approximation and system identification theory. In order to characterize network traffic behaviors, we present fifteen features and use them as the input signals in our system. We then evaluate our approach with the 1999 DARPA intrusion detection dataset and conduct a comprehensive analysis of the intrusions in the dataset. Evaluation results show that the approach achieves high-detection rates in terms of both attack instances and attack types. Furthermore, we conduct a full day's evaluation in a real large-scale WiFi ISP network where five attack types are successfully detected from over 30 millions flows. Trimming of mammalian transcriptional networks using network component analysis Liao James C Full Text Available Abstract Background Network Component Analysis (NCA has been used to deduce the activities of transcription factors (TFs from gene expression data and the TF-gene binding relationship. However, the TF-gene interaction varies in different environmental conditions and tissues, but such information is rarely available and cannot be predicted simply by motif analysis. Thus, it is beneficial to identify key TF-gene interactions under the experimental condition based on transcriptome data. Such information would be useful in identifying key regulatory pathways and gene markers of TFs in further studies. Results We developed an algorithm to trim network connectivity such that the important regulatory interactions between the TFs and the genes were retained and the regulatory signals were deduced. Theoretical studies demonstrated that the regulatory signals were accurately reconstructed even in the case where only three independent transcriptome datasets were available. At least 80% of the main target genes were correctly predicted in the extreme condition of high noise level and small number of datasets. Our algorithm was tested with transcriptome data taken from mice under rapamycin treatment. The initial network topology from the literature contains 70 TFs, 778 genes, and 1423 edges between the TFs and genes. Our method retained 1074 edges (i.e. 75% of the original edge number and identified 17 TFs as being significantly perturbed under the experimental condition. Twelve of these TFs are involved in MAPK signaling or myeloid leukemia pathways defined in the KEGG database, or are known to physically interact with each other. Additionally, four of these TFs, which are Hif1a, Cebpb, Nfkb1, and Atf1, are known targets of rapamycin. Furthermore, the trimmed network was able to predict Eno1 as an important target of Hif1a; this key interaction could not be detected without trimming the regulatory network. Conclusions The advantage of our new algorithm Social network analysis applied to team sports analysis Clemente, Filipe Manuel; Mendes, Rui Sousa Explaining how graph theory and social network analysis can be applied to team sports analysis, This book presents useful approaches, models and methods that can be used to characterise the overall properties of team networks and identify the prominence of each team player. Exploring the different possible network metrics that can be utilised in sports analysis, their possible applications and variances from situation to situation, the respective chapters present an array of illustrative case studies. Identifying the general concepts of social network analysis and network centrality metrics, readers are shown how to generate a methodological protocol for data collection. As such, the book provides a valuable resource for students of the sport sciences, sports engineering, applied computation and the social sciences. Fast network centrality analysis using GPUs Shi Zhiao Full Text Available Abstract Background With the exploding volume of data generated by continuously evolving high-throughput technologies, biological network analysis problems are growing larger in scale and craving for more computational power. General Purpose computation on Graphics Processing Units (GPGPU provides a cost-effective technology for the study of large-scale biological networks. Designing algorithms that maximize data parallelism is the key in leveraging the power of GPUs. Results We proposed an efficient data parallel formulation of the All-Pairs Shortest Path problem, which is the key component for shortest path-based centrality computation. A betweenness centrality algorithm built upon this formulation was developed and benchmarked against the most recent GPU-based algorithm. Speedup between 11 to 19% was observed in various simulated scale-free networks. We further designed three algorithms based on this core component to compute closeness centrality, eccentricity centrality and stress centrality. To make all these algorithms available to the research community, we developed a software package gpu-fan (GPU-based Fast Analysis of Networks for CUDA enabled GPUs. Speedup of 10-50Ã— compared with CPU implementations was observed for simulated scale-free networks and real world biological networks. Conclusions gpu-fan provides a significant performance improvement for centrality computation in large-scale networks. Source code is available under the GNU Public License (GPL at http://bioinfo.vanderbilt.edu/gpu-fan/. Crawling Facebook for Social Network Analysis Purposes Catanese, Salvatore A.; De Meo, Pasquale; Ferrara, Emilio; Fiumara, Giacomo; Provetti, Alessandro We describe our work in the collection and analysis of massive data describing the connections between participants to online social networks. Alternative approaches to social network data collection are defined and evaluated in practice, against the popular Facebook Web site. Thanks to our ad-hoc, privacy-compliant crawlers, two large samples, comprising millions of connections, have been collected; the data is anonymous and organized as an undirected graph. We describe a set of tools that w... Automated Analysis of Security in Networking Systems Buchholtz, Mikael such networking systems are modelled in the process calculus LySa. On top of this programming language based formalism an analysis is developed, which relies on techniques from data and control ow analysis. These are techniques that can be fully automated, which make them an ideal basis for tools targeted at non... Comparison of gene co-networks reveals the molecular mechanisms of the rice (Oryza sativa L.) response to Rhizoctonia solani AG1 IA infection. Zhang, Jinfeng; Zhao, Wenjuan; Fu, Rong; Fu, Chenglin; Wang, Lingxia; Liu, Huainian; Li, Shuangcheng; Deng, Qiming; Wang, Shiquan; Zhu, Jun; Liang, Yueyang; Li, Ping; Zheng, Aiping Rhizoctonia solani causes rice sheath blight, an important disease affecting the growth of rice (Oryza sativa L.). Attempts to control the disease have met with little success. Based on transcriptional profiling, we previously identified more than 11,947 common differentially expressed genes (TPMâ€‰>â€‰10) between the rice genotypes TeQing and Lemont. In the current study, we extended these findings by focusing on an analysis of gene co-expression in response to R. solani AG1 IA and identified gene modules within the networks through weighted gene co-expression network analysis (WGCNA). We compared the different genes assigned to each module and the biological interpretations of gene co-expression networks at early and later modules in the two rice genotypes to reveal differential responses to AG1 IA. Our results show that different changes occurred in the two rice genotypes and that the modules in the two groups contain a number of candidate genes possibly involved in pathogenesis, such as the VQ protein. Furthermore, these gene co-expression networks provide comprehensive transcriptional information regarding gene expression in rice in response to AG1 IA. The co-expression networks derived from our data offer ideas for follow-up experimentation that will help advance our understanding of the translational regulation of rice gene expression changes in response to AG1 IA. Network Analysis in Community Psychology: Looking Back, Looking Forward Neal, Zachary P.; Neal, Jennifer Watling Highlights Network analysis is ideally suited for community psychology research because it focuses on context. Use of network analysis in community psychology is growing. Network analysis in community psychology has employed some potentially problematic practices. Recommended practices are identified to improve network analysis in community psychology. A bioinformatics prediction approach towards analyzing the glycosylation, co-expression and interaction patterns of epithelial membrane antigen (EMA/MUC1) Kalra, Rajkumar S., E-mail: renu-wadhwa@aist.go.jp; Wadhwa, Renu, E-mail: renu-wadhwa@aist.go.jp [Cell Proliferation Research Group and DBT-AIST International Laboratory for Advanced Biomedicine, National Institute of Advanced Industrial Science and Technology (AIST Central 4), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562 (Japan) Epithelial membrane antigen (EMA or MUC1) is a heavily glycosylated, type I transmembrane glycoprotein commonly expressed by epithelial cells of duct organs. It has been shown to be aberrantly glycosylated in several diseases including cancer. Protein sequence based annotation and analysis of glycosylation profile of glycoproteins by robust computational and comprehensive algorithms provides possible insights to the mechanism(s) of anomalous glycosylation. In present report, by using a number of bioinformatics applications we studied EMA/MUC1 and explored its trans-membrane structural domain sequence that is widely subjected to glycosylation. Exploration of different extracellular motifs led to prediction of N and O-linked glycosylation target sites. Based on the putative O-linked target sites, glycosylated moieties and pathways were envisaged. Furthermore, Protein network analysis demonstrated physical interaction of EMA with a number of proteins and confirmed its functional involvement in cell growth and proliferation pathways. Gene Ontology analysis suggested an involvement of EMA in a number of functions including signal transduction, protein binding, processing and transport along with glycosylation. Thus, present study explored potential of bioinformatics prediction approach in analyzing glycosylation, co-expression and interaction patterns of EMA/MUC1 glycoprotein. Kalra, Rajkumar S.; Wadhwa, Renu Epithelial membrane antigen (EMA or MUC1) is a heavily glycosylated, type I transmembrane glycoprotein commonly expressed by epithelial cells of duct organs. It has been shown to be aberrantly glycosylated in several diseases including cancer. Protein sequence based annotation and analysis of glycosylation profile of glycoproteins by robust computational and comprehensive algorithms provides possible insights to the mechanism(s) of anomalous glycosylation. In present report, by using a number of bioinformatics applications we studied EMA/MUC1 and explored its trans-membrane structural domain sequence that is widely subjected to glycosylation. Exploration of different extracellular motifs led to prediction of N and O-linked glycosylation target sites. Based on the putative O-linked target sites, glycosylated moieties and pathways were envisaged. Furthermore, Protein network analysis demonstrated physical interaction of EMA with a number of proteins and confirmed its functional involvement in cell growth and proliferation pathways. Gene Ontology analysis suggested an involvement of EMA in a number of functions including signal transduction, protein binding, processing and transport along with glycosylation. Thus, present study explored potential of bioinformatics prediction approach in analyzing glycosylation, co-expression and interaction patterns of EMA/MUC1 glycoprotein Framework for network modularization and Bayesian network analysis to investigate the perturbed metabolic network Kim Hyun Full Text Available Abstract Background Genome-scale metabolic network models have contributed to elucidating biological phenomena, and predicting gene targets to engineer for biotechnological applications. With their increasing importance, their precise network characterization has also been crucial for better understanding of the cellular physiology. Results We herein introduce a framework for network modularization and Bayesian network analysis (FMB to investigate organismâ€™s metabolism under perturbation. FMB reveals direction of influences among metabolic modules, in which reactions with similar or positively correlated flux variation patterns are clustered, in response to specific perturbation using metabolic flux data. With metabolic flux data calculated by constraints-based flux analysis under both control and perturbation conditions, FMB, in essence, reveals the effects of specific perturbations on the biological system through network modularization and Bayesian network analysis at metabolic modular level. As a demonstration, this framework was applied to the genetically perturbed Escherichia coli metabolism, which is a lpdA gene knockout mutant, using its genome-scale metabolic network model. Conclusions After all, it provides alternative scenarios of metabolic flux distributions in response to the perturbation, which are complementary to the data obtained from conventionally available genome-wide high-throughput techniques or metabolic flux analysis. Framework for network modularization and Bayesian network analysis to investigate the perturbed metabolic network. Kim, Hyun Uk; Kim, Tae Yong; Lee, Sang Yup Genome-scale metabolic network models have contributed to elucidating biological phenomena, and predicting gene targets to engineer for biotechnological applications. With their increasing importance, their precise network characterization has also been crucial for better understanding of the cellular physiology. We herein introduce a framework for network modularization and Bayesian network analysis (FMB) to investigate organism's metabolism under perturbation. FMB reveals direction of influences among metabolic modules, in which reactions with similar or positively correlated flux variation patterns are clustered, in response to specific perturbation using metabolic flux data. With metabolic flux data calculated by constraints-based flux analysis under both control and perturbation conditions, FMB, in essence, reveals the effects of specific perturbations on the biological system through network modularization and Bayesian network analysis at metabolic modular level. As a demonstration, this framework was applied to the genetically perturbed Escherichia coli metabolism, which is a lpdA gene knockout mutant, using its genome-scale metabolic network model. After all, it provides alternative scenarios of metabolic flux distributions in response to the perturbation, which are complementary to the data obtained from conventionally available genome-wide high-throughput techniques or metabolic flux analysis. Social network analysis of study environment BlaÅ¾enka Divjak Full Text Available Student working environment influences student learning and achievement level. In this respect social aspects of studentsâ€™ formal and non-formal learning play special role in learning environment. The main research problem of this paper is to find out if students' academic performance influences their position in different students' social networks. Further, there is a need to identify other predictors of this position. In the process of problem solving we use the Social Network Analysis (SNA that is based on the data we collected from the students at the Faculty of Organization and Informatics, University of Zagreb. There are two data samples: in the basic sample N=27 and in the extended sample N=52. We collected data on social-demographic position, academic performance, learning and motivation styles, student status (full-time/part-time, attitudes towards individual and teamwork as well as informal cooperation. Afterwards five different networks (exchange of learning materials, teamwork, informal communication, basic and aggregated social network were constructed. These networks were analyzed with different metrics and the most important were betweenness, closeness and degree centrality. The main result is, firstly, that the position in a social network cannot be forecast only by academic success and, secondly, that part-time students tend to form separate groups that are poorly connected with full-time students. In general, position of a student in social networks in study environment can influence student learning as well as her/his future employability and therefore it is worthwhile to be investigated. NAPS: Network Analysis of Protein Structures Chakrabarty, Broto; Parekh, Nita Traditionally, protein structures have been analysed by the secondary structure architecture and fold arrangement. An alternative approach that has shown promise is modelling proteins as a network of non-covalent interactions between amino acid residues. The network representation of proteins provide a systems approach to topological analysis of complex three-dimensional structures irrespective of secondary structure and fold type and provide insights into structure-function relationship. We have developed a web server for network based analysis of protein structures, NAPS, that facilitates quantitative and qualitative (visual) analysis of residueâ€“residue interactions in: single chains, protein complex, modelled protein structures and trajectories (e.g. from molecular dynamics simulations). The user can specify atom type for network construction, distance range (in Ã…) and minimal amino acid separation along the sequence. NAPS provides users selection of node(s) and its neighbourhood based on centrality measures, physicochemical properties of amino acids or cluster of well-connected residues (k-cliques) for further analysis. Visual analysis of interacting domains and protein chains, and shortest path lengths between pair of residues are additional features that aid in functional analysis. NAPS support various analyses and visualization views for identifying functional residues, provide insight into mechanisms of protein folding, domain-domain and proteinâ€“protein interactions for understanding communication within and between proteins. URL:http://bioinf.iiit.ac.in/NAPS/. PMID:27151201 Information flow analysis of interactome networks. Patrycja Vasilyev Missiuro Full Text Available Recent studies of cellular networks have revealed modular organizations of genes and proteins. For example, in interactome networks, a module refers to a group of interacting proteins that form molecular complexes and/or biochemical pathways and together mediate a biological process. However, it is still poorly understood how biological information is transmitted between different modules. We have developed information flow analysis, a new computational approach that identifies proteins central to the transmission of biological information throughout the network. In the information flow analysis, we represent an interactome network as an electrical circuit, where interactions are modeled as resistors and proteins as interconnecting junctions. Construing the propagation of biological signals as flow of electrical current, our method calculates an information flow score for every protein. Unlike previous metrics of network centrality such as degree or betweenness that only consider topological features, our approach incorporates confidence scores of protein-protein interactions and automatically considers all possible paths in a network when evaluating the importance of each protein. We apply our method to the interactome networks of Saccharomyces cerevisiae and Caenorhabditis elegans. We find that the likelihood of observing lethality and pleiotropy when a protein is eliminated is positively correlated with the protein's information flow score. Even among proteins of low degree or low betweenness, high information scores serve as a strong predictor of loss-of-function lethality or pleiotropy. The correlation between information flow scores and phenotypes supports our hypothesis that the proteins of high information flow reside in central positions in interactome networks. We also show that the ranks of information flow scores are more consistent than that of betweenness when a large amount of noisy data is added to an interactome. Finally, we A statistical analysis of UK financial networks Chu, J.; Nadarajah, S. In recent years, with a growing interest in big or large datasets, there has been a rise in the application of large graphs and networks to financial big data. Much of this research has focused on the construction and analysis of the network structure of stock markets, based on the relationships between stock prices. Motivated by Boginski et al. (2005), who studied the characteristics of a network structure of the US stock market, we construct network graphs of the UK stock market using same method. We fit four distributions to the degree density of the vertices from these graphs, the Pareto I, FrÃ©chet, lognormal, and generalised Pareto distributions, and assess the goodness of fit. Our results show that the degree density of the complements of the market graphs, constructed using a negative threshold value close to zero, can be fitted well with the FrÃ©chet and lognormal distributions. Network Analysis of Rodent Transcriptomes in Spaceflight Ramachandran, Maya; Fogle, Homer; Costes, Sylvain Network analysis methods leverage prior knowledge of cellular systems and the statistical and conceptual relationships between analyte measurements to determine gene connectivity. Correlation and conditional metrics are used to infer a network topology and provide a systems-level context for cellular responses. Integration across multiple experimental conditions and omics domains can reveal the regulatory mechanisms that underlie gene expression. GeneLab has assembled rich multi-omic (transcriptomics, proteomics, epigenomics, and epitranscriptomics) datasets for multiple murine tissues from the Rodent Research 1 (RR-1) experiment. RR-1 assesses the impact of 37 days of spaceflight on gene expression across a variety of tissue types, such as adrenal glands, quadriceps, gastrocnemius, tibalius anterior, extensor digitorum longus, soleus, eye, and kidney. Network analysis is particularly useful for RR-1 -omics datasets because it reinforces subtle relationships that may be overlooked in isolated analyses and subdues confounding factors. Our objective is to use network analysis to determine potential target nodes for therapeutic intervention and identify similarities with existing disease models. Multiple network algorithms are used for a higher confidence consensus. Complex network analysis of state spaces for random Boolean networks Shreim, Amer [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Berdahl, Andrew [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Sood, Vishal [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Grassberger, Peter [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Paczuski, Maya [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada) We apply complex network analysis to the state spaces of random Boolean networks (RBNs). An RBN contains N Boolean elements each with K inputs. A directed state space network (SSN) is constructed by linking each dynamical state, represented as a node, to its temporal successor. We study the heterogeneity of these SSNs at both local and global scales, as well as sample to-sample fluctuations within an ensemble of SSNs. We use in-degrees of nodes as a local topological measure, and the path diversity (Shreim A et al 2007 Phys. Rev. Lett. 98 198701) of an SSN as a global topological measure. RBNs with 2 {<=} K {<=} 5 exhibit non-trivial fluctuations at both local and global scales, while K = 2 exhibits the largest sample-to-sample (possibly non-self-averaging) fluctuations. We interpret the observed 'multi scale' fluctuations in the SSNs as indicative of the criticality and complexity of K = 2 RBNs. 'Garden of Eden' (GoE) states are nodes on an SSN that have in-degree zero. While in-degrees of non-GoE nodes for K > 1 SSNs can assume any integer value between 0 and 2{sup N}, for K = 1 all the non-GoE nodes in a given SSN have the same in-degree which is always a power of two. Shreim, Amer; Berdahl, Andrew; Sood, Vishal; Grassberger, Peter; Paczuski, Maya We apply complex network analysis to the state spaces of random Boolean networks (RBNs). An RBN contains N Boolean elements each with K inputs. A directed state space network (SSN) is constructed by linking each dynamical state, represented as a node, to its temporal successor. We study the heterogeneity of these SSNs at both local and global scales, as well as sample to-sample fluctuations within an ensemble of SSNs. We use in-degrees of nodes as a local topological measure, and the path diversity (Shreim A et al 2007 Phys. Rev. Lett. 98 198701) of an SSN as a global topological measure. RBNs with 2 â‰¤ K â‰¤ 5 exhibit non-trivial fluctuations at both local and global scales, while K = 2 exhibits the largest sample-to-sample (possibly non-self-averaging) fluctuations. We interpret the observed 'multi scale' fluctuations in the SSNs as indicative of the criticality and complexity of K = 2 RBNs. 'Garden of Eden' (GoE) states are nodes on an SSN that have in-degree zero. While in-degrees of non-GoE nodes for K > 1 SSNs can assume any integer value between 0 and 2 N , for K = 1 all the non-GoE nodes in a given SSN have the same in-degree which is always a power of two Features analysis for identification of date and party hubs in protein interaction network of Saccharomyces Cerevisiae Araabi Babak N Full Text Available Abstract Background It has been understood that biological networks have modular organizations which are the sources of their observed complexity. Analysis of networks and motifs has shown that two types of hubs, party hubs and date hubs, are responsible for this complexity. Party hubs are local coordinators because of their high co-expressions with their partners, whereas date hubs display low co-expressions and are assumed as global connectors. However there is no mutual agreement on these concepts in related literature with different studies reporting their results on different data sets. We investigated whether there is a relation between the biological features of Saccharomyces Cerevisiae's proteins and their roles as non-hubs, intermediately connected, party hubs, and date hubs. We propose a classifier that separates these four classes. Results We extracted different biological characteristics including amino acid sequences, domain contents, repeated domains, functional categories, biological processes, cellular compartments, disordered regions, and position specific scoring matrix from various sources. Several classifiers are examined and the best feature-sets based on average correct classification rate and correlation coefficients of the results are selected. We show that fusion of five feature-sets including domains, Position Specific Scoring Matrix-400, cellular compartments level one, and composition pairs with two and one gaps provide the best discrimination with an average correct classification rate of 77%. Conclusions We study a variety of known biological feature-sets of the proteins and show that there is a relation between domains, Position Specific Scoring Matrix-400, cellular compartments level one, composition pairs with two and one gaps of Saccharomyces Cerevisiae's proteins, and their roles in the protein interaction network as non-hubs, intermediately connected, party hubs and date hubs. This study also confirms the Northern emporia and maritime networks. Modelling past communication using archaeological network analysis SindbÃ¦k, SÃ¸ren Michael preserve patterns of thisinteraction. Formal network analysis and modelling holds the potential to identify anddemonstrate such patterns, where traditional methods often prove inadequate. Thearchaeological study of communication networks in the past, however, calls for radically different analytical...... this is not a problem of network analysis, but network synthesis: theclassic problem of cracking codes or reconstructing black-box circuits. It is proposedthat archaeological approaches to network synthesis must involve a contextualreading of network data: observations arising from individual contexts, morphologies... Vulnerability analysis methods for road networks BÃl, Michal; VodÃ¡k, Rostislav; KubeÄ�ek, Jan; Rebok, TomÃ¡Å¡; Svoboda, TomÃ¡Å¡ Road networks rank among the most important lifelines of modern society. They can be damaged by either random or intentional events. Roads are also often affected by natural hazards, the impacts of which are both direct and indirect. Whereas direct impacts (e.g. roads damaged by a landslide or due to flooding) are localized in close proximity to the natural hazard occurrence, the indirect impacts can entail widespread service disabilities and considerable travel delays. The change in flows in the network may affect the population living far from the places originally impacted by the natural disaster. These effects are primarily possible due to the intrinsic nature of this system. The consequences and extent of the indirect costs also depend on the set of road links which were damaged, because the road links differ in terms of their importance. The more robust (interconnected) the road network is, the less time is usually needed to secure the serviceability of an area hit by a disaster. These kinds of networks also demonstrate a higher degree of resilience. Evaluating road network structures is therefore essential in any type of vulnerability and resilience analysis. There are a range of approaches used for evaluation of the vulnerability of a network and for identification of the weakest road links. Only few of them are, however, capable of simulating the impacts of the simultaneous closure of numerous links, which often occurs during a disaster. The primary problem is that in the case of a disaster, which usually has a large regional extent, the road network may remain disconnected. The majority of the commonly used indices use direct computation of the shortest paths or time between OD (origin - destination) pairs and therefore cannot be applied when the network breaks up into two or more components. Since extensive break-ups often occur in cases of major disasters, it is important to study the network vulnerability in these cases as well, so that appropriate Diversity Performance Analysis on Multiple HAP Networks Dong, Feihong; Li, Min; Gong, Xiangwu; Li, Hongjun; Gao, Fengyue One of the main design challenges in wireless sensor networks (WSNs) is achieving a high-data-rate transmission for individual sensor devices. The high altitude platform (HAP) is an important communication relay platform for WSNs and next-generation wireless networks. Multiple-input multiple-output (MIMO) techniques provide the diversity and multiplexing gain, which can improve the network performance effectively. In this paper, a virtual MIMO (V-MIMO) model is proposed by networking multiple HAPs with the concept of multiple assets in view (MAV). In a shadowed Rician fading channel, the diversity performance is investigated. The probability density function (PDF) and cumulative distribution function (CDF) of the received signal-to-noise ratio (SNR) are derived. In addition, the average symbol error rate (ASER) with BPSK and QPSK is given for the V-MIMO model. The system capacity is studied for both perfect channel state information (CSI) and unknown CSI individually. The ergodic capacity with various SNR and Rician factors for different network configurations is also analyzed. The simulation results validate the effectiveness of the performance analysis. It is shown that the performance of the HAPs network in WSNs can be significantly improved by utilizing the MAV to achieve overlapping coverage, with the help of the V-MIMO techniques. PMID:26134102 Feihong Dong Full Text Available One of the main design challenges in wireless sensor networks (WSNs is achieving a high-data-rate transmission for individual sensor devices. The high altitude platform (HAP is an important communication relay platform for WSNs and next-generation wireless networks. Multiple-input multiple-output (MIMO techniques provide the diversity and multiplexing gain, which can improve the network performance effectively. In this paper, a virtual MIMO (V-MIMO model is proposed by networking multiple HAPs with the concept of multiple assets in view (MAV. In a shadowed Rician fading channel, the diversity performance is investigated. The probability density function (PDF and cumulative distribution function (CDF of the received signal-to-noise ratio (SNR are derived. In addition, the average symbol error rate (ASER with BPSK and QPSK is given for the V-MIMO model. The system capacity is studied for both perfect channel state information (CSI and unknown CSI individually. The ergodic capacity with various SNR and Rician factors for different network configurations is also analyzed. The simulation results validate the effectiveness of the performance analysis. It is shown that the performance of the HAPs network in WSNs can be significantly improved by utilizing the MAV to achieve overlapping coverage, with the help of the V-MIMO techniques. Mixed Methods Analysis of Enterprise Social Networks Behrendt, Sebastian; Richter, Alexander; Trier, Matthias The increasing use of enterprise social networks (ESN) generates vast amounts of data, giving researchers and managerial decision makers unprecedented opportunities for analysis. However, more transparency about the available data dimensions and how these can be combined is needed to yield accurate... Nonlinear Time Series Analysis via Neural Networks VolnÃ¡, Eva; JanoÅ¡ek, Michal; Kocian, VÃ¡clav; Kotyrba, Martin This article deals with a time series analysis based on neural networks in order to make an effective forex market [Moore and Roche, J. Int. Econ. 58, 387-411 (2002)] pattern recognition. Our goal is to find and recognize important patterns which repeatedly appear in the market history to adapt our trading system behaviour based on them. Integrating neural network technology and noise analysis Uhrig, R.E.; Oak Ridge National Lab., TN The integrated use of neural network and noise analysis technologies offers advantages not available by the use of either technology alone. The application of neural network technology to noise analysis offers an opportunity to expand the scope of problems where noise analysis is useful and unique ways in which the integration of these technologies can be used productively. The two-sensor technique, in which the responses of two sensors to an unknown driving source are related, is used to demonstration such integration. The relationship between power spectral densities (PSDs) of accelerometer signals is derived theoretically using noise analysis to demonstrate its uniqueness. This relationship is modeled from experimental data using a neural network when the system is working properly, and the actual PSD of one sensor is compared with the PSD of that sensor predicted by the neural network using the PSD of the other sensor as an input. A significant deviation between the actual and predicted PSDs indicate that system is changing (i.e., failing). Experiments carried out on check values and bearings illustrate the usefulness of the methodology developed. (Author) Reliability Analysis Techniques for Communication Networks in Nuclear Power Plant Lim, T. J.; Jang, S. C.; Kang, H. G.; Kim, M. C.; Eom, H. S.; Lee, H. J. The objectives of this project is to investigate and study existing reliability analysis techniques for communication networks in order to develop reliability analysis models for nuclear power plant's safety-critical networks. It is necessary to make a comprehensive survey of current methodologies for communication network reliability. Major outputs of this study are design characteristics of safety-critical communication networks, efficient algorithms for quantifying reliability of communication networks, and preliminary models for assessing reliability of safety-critical communication networks Time series analysis of temporal networks Sikdar, Sandipan; Ganguly, Niloy; Mukherjee, Animesh A common but an important feature of all real-world networks is that they are temporal in nature, i.e., the network structure changes over time. Due to this dynamic nature, it becomes difficult to propose suitable growth models that can explain the various important characteristic properties of these networks. In fact, in many application oriented studies only knowing these properties is sufficient. For instance, if one wishes to launch a targeted attack on a network, this can be done even without the knowledge of the full network structure; rather an estimate of some of the properties is sufficient enough to launch the attack. We, in this paper show that even if the network structure at a future time point is not available one can still manage to estimate its properties. We propose a novel method to map a temporal network to a set of time series instances, analyze them and using a standard forecast model of time series, try to predict the properties of a temporal network at a later time instance. To our aim, we consider eight properties such as number of active nodes, average degree, clustering coefficient etc. and apply our prediction framework on them. We mainly focus on the temporal network of human face-to-face contacts and observe that it represents a stochastic process with memory that can be modeled as Auto-Regressive-Integrated-Moving-Average (ARIMA). We use cross validation techniques to find the percentage accuracy of our predictions. An important observation is that the frequency domain properties of the time series obtained from spectrogram analysis could be used to refine the prediction framework by identifying beforehand the cases where the error in prediction is likely to be high. This leads to an improvement of 7.96% (for error level â‰¤20%) in prediction accuracy on an average across all datasets. As an application we show how such prediction scheme can be used to launch targeted attacks on temporal networks. Contribution to the Topical Issue Network analysis for the visualization and analysis of qualitative data. Pokorny, Jennifer J; Norman, Alex; Zanesco, Anthony P; Bauer-Wu, Susan; Sahdra, Baljinder K; Saron, Clifford D We present a novel manner in which to visualize the coding of qualitative data that enables representation and analysis of connections between codes using graph theory and network analysis. Network graphs are created from codes applied to a transcript or audio file using the code names and their chronological location. The resulting network is a representation of the coding data that characterizes the interrelations of codes. This approach enables quantification of qualitative codes using network analysis and facilitates examination of associations of network indices with other quantitative variables using common statistical procedures. Here, as a proof of concept, we applied this method to a set of interview transcripts that had been coded in 2 different ways and the resultant network graphs were examined. The creation of network graphs allows researchers an opportunity to view and share their qualitative data in an innovative way that may provide new insights and enhance transparency of the analytical process by which they reach their conclusions. (PsycINFO Database Record (c) 2018 APA, all rights reserved). Capacity analysis of wireless mesh networks \| Gumel \| Nigerian ... ... number of nodes (n) in a linear topology. The degradation is found to be higher in a fully mesh network as a result of increase in interference and MAC layer contention in the network. Key words: Wireless mesh network (WMN), Adhoc network, Network capacity analysis, Bottleneck collision domain, Medium access controlÂ ... Capacity analysis of vehicular communication networks Lu, Ning This SpringerBrief focuses on the network capacity analysis of VANETs, a key topic as fundamental guidance on design and deployment of VANETs is very limited. Moreover, unique characteristics of VANETs impose distinguished challenges on such an investigation. This SpringerBrief first introduces capacity scaling laws for wireless networks and briefly reviews the prior arts in deriving the capacity of VANETs. It then studies the unicast capacity considering the socialized mobility model of VANETs. With vehicles communicating based on a two-hop relaying scheme, the unicast capacity bound is deriv Differential co-expression and regulation analyses reveal different mechanisms underlying major depressive disorder and subsyndromal symptomatic depression. Xu, Fan; Yang, Jing; Chen, Jin; Wu, Qingyuan; Gong, Wei; Zhang, Jianguo; Shao, Weihua; Mu, Jun; Yang, Deyu; Yang, Yongtao; Li, Zhiwei; Xie, Peng Recent depression research has revealed a growing awareness of how to best classify depression into depressive subtypes. Appropriately subtyping depression can lead to identification of subtypes that are more responsive to current pharmacological treatment and aid in separating out depressed patients in which current antidepressants are not particularly effective. Differential co-expression analysis (DCEA) and differential regulation analysis (DRA) were applied to compare the transcriptomic profiles of peripheral blood lymphocytes from patients with two depressive subtypes: major depressive disorder (MDD) and subsyndromal symptomatic depression (SSD). Six differentially regulated genes (DRGs) (FOSL1, SRF, JUN, TFAP4, SOX9, and HLF) and 16 transcription factor-to-target differentially co-expressed gene links or pairs (TF2target DCLs) appear to be the key differential factors in MDD; in contrast, one DRG (PATZ1) and eight TF2target DCLs appear to be the key differential factors in SSD. There was no overlap between the MDD target genes and SSD target genes. Venlafaxine (Efexorâ„¢, Effexorâ„¢) appears to have a significant effect on the gene expression profile of MDD patients but no significant effect on the gene expression profile of SSD patients. DCEA and DRA revealed no apparent similarities between the differential regulatory processes underlying MDD and SSD. This bioinformatic analysis may provide novel insights that can support future antidepressant R&D efforts. Co-expression of CD147 and GLUT-1 indicates radiation resistance and poor prognosis in cervical squamous cell carcinoma. Huang, Xin-Qiong; Chen, Xiang; Xie, Xiao-Xue; Zhou, Qin; Li, Kai; Li, Shan; Shen, Liang-Fang; Su, Juan The aim of this study was to investigate the association of CD147 and GLUT-1, which play important roles in glycolysis in response to radiotherapy and clinical outcomes in patients with locally advanced cervical squamous cell carcinoma (LACSCC). The records of 132 female patients who received primary radiation therapy to treat LACSCC at FIGO stages IB-IVA were retrospectively reviewed. Forty-seven patients with PFS (progression-free survival) of less than 36 months were regarded as radiation-resistant. Eighty-five patients with PFS longer than 36 months were regarded as radiation-sensitive. Using pretreatment paraffin-embedded tissues, we evaluated CD147 and GLUT-1 expression by immunohistochemistry. Overexpression of CD147, GLUT-1, and CD147 and GLUT-1 combined were 44.7%, 52.9% and 36.5%, respectively, in the radiation-sensitive group, and 91.5%, 89.4% and 83.0%, respectively, in the radiation-resistant group. The 5-year progress free survival (PFS) rates in the CD147-low, CD147-high, GLUT-1-low, GLUT-1-high, CD147- and/or GLUT-1-low and CD147- and GLUT-1- dual high expression groups were 66.79%, 87.10%, 52.78%, 85.82%, 55.94%, 82.90% and 50.82%, respectively. CD147 and GLUT-1 co-expression, FIGO stage and tumor diameter were independent poor prognostic factors for patients with LACSCC in multivariate Cox regression analysis. Patients with high expression of CD147 alone, GLUT-1 alone or co-expression of CD147 and GLUT-1 showed greater resistance to radiotherapy and a shorter PFS than those with low expression. In particular, co-expression of CD147 and GLUT-1 can be considered as a negative independent prognostic factor. Co-Expression of Bmi-1 and Podoplanin Predicts Overall Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Radio(chemo)therapy Vormittag, Laurenz; Thurnher, Dietmar; Geleff, Silvana; Pammer, Johannes; Heiduschka, Gregor; Brunner, Markus; Grasl, Matthaeus Ch.; Erovic, Boban M. Purpose: This study was conducted to determine the expression of Bmi-1 and podoplanin in healthy oral mucosa and in untreated tumor tissues samples of patients with squamous cell carcinomas of the head and neck. All patients were treated by primary radio(chemo)therapy. Methods and Materials: The expression of Bmi-1 and podoplanin was immunohistochemically evaluated in 12 normal oral mucosa and 63 tumor specimens and correlated with patients' clinical data. Results: In healthy mucosa expression of Bmi-1 and podoplanin was restricted to the basal cell layer. Expression of both proteins was found in 79% and 86% of our tumor samples, respectively. In 17 and 8 samples, Bmi-1 and podoplanin were co-expressed at the invasive border or diffuse in the bulk of the tumor, respectively. Univariate analysis showed that the co-expression of Bmi-1 and podoplanin correlated to decreased overall survival (p = 0.044). Moreover, multivariate testing identified high expression of podoplanin (p = 0.044), co-expression of Bmi-1 and podoplanin (p = 0.007) and lack of response to therapy (p < 0.0001) as predictors of shortened overall survival in patients treated with primary radio(chemo)therapy. Conclusions: Bmi-1 and podoplanin are expressed at the invasive front of squamous cell carcinomas of the head and neck. Co-expression of Bmi-1 and podoplanin predicts significantly overall survival of patients treated with primary radio(chemo)therapy Mathematical Analysis of Urban Spatial Networks Blanchard, Philippe Cities can be considered to be among the largest and most complex artificial networks created by human beings. Due to the numerous and diverse human-driven activities, urban network topology and dynamics can differ quite substantially from that of natural networks and so call for an alternative method of analysis. The intent of the present monograph is to lay down the theoretical foundations for studying the topology of compact urban patterns, using methods from spectral graph theory and statistical physics. These methods are demonstrated as tools to investigate the structure of a number of real cities with widely differing properties: medieval German cities, the webs of city canals in Amsterdam and Venice, and a modern urban structure such as found in Manhattan. Last but not least, the book concludes by providing a brief overview of possible applications that will eventually lead to a useful body of knowledge for architects, urban planners and civil engineers. Intentional risk management through complex networks analysis Chapela, Victor; Moral, Santiago; Romance, Miguel This book combines game theory and complex networks to examine intentional technological risk through modeling. As information security risks are in constant evolution, Â the methodologies and tools to manage them must evolve to an ever-changing environment. A formal global methodology is explained Â in this book, which is able to analyze risks in cyber security based on complex network models and ideas extracted from the Nash equilibrium. A risk management methodology for IT critical infrastructures is introduced which provides guidance and analysis on decision making models and real situations. This model manages the risk of succumbing to a digital attack and assesses an attack from the following three variables: income obtained, expense needed to carry out an attack, and the potential consequences for an attack. Graduate students and researchers interested in cyber security, complex network applications and intentional risk will find this book useful as it is filled with a number of models, methodologies a... A Network Thermodynamic Approach to Compartmental Analysis Mikulecky, D. C.; Huf, E. G.; Thomas, S. R. We introduce a general network thermodynamic method for compartmental analysis which uses a compartmental model of sodium flows through frog skin as an illustrative example (Huf and Howell, 1974a). We use network thermodynamics (Mikulecky et al., 1977b) to formulate the problem, and a circuit simulation program (ASTEC 2, SPICE2, or PCAP) for computation. In this way, the compartment concentrations and net fluxes between compartments are readily obtained for a set of experimental conditions involving a square-wave pulse of labeled sodium at the outer surface of the skin. Qualitative features of the influx at the outer surface correlate very well with those observed for the short circuit current under another similar set of conditions by Morel and LeBlanc (1975). In related work, the compartmental model is used as a basis for simulation of the short circuit current and sodium flows simultaneously using a two-port network (Mikulecky et al., 1977a, and Mikulecky et al., A network thermodynamic model for short circuit current transients in frog skin. Manuscript in preparation; Gary-Bobo et al., 1978). The network approach lends itself to computation of classic compartmental problems in a simple manner using circuit simulation programs (Chua and Lin, 1975), and it further extends the compartmental models to more complicated situations involving coupled flows and non-linearities such as concentration dependencies, chemical reaction kinetics, etc. PMID:262387 Matrix factorization reveals aging-specific co-expression gene modules in the fat and muscle tissues in nonhuman primates Wang, Yongcui; Zhao, Weiling; Zhou, Xiaobo Accurate identification of coherent transcriptional modules (subnetworks) in adipose and muscle tissues is important for revealing the related mechanisms and co-regulated pathways involved in the development of aging-related diseases. Here, we proposed a systematically computational approach, called ICEGM, to Identify the Co-Expression Gene Modules through a novel mathematical framework of Higher-Order Generalized Singular Value Decomposition (HO-GSVD). ICEGM was applied on the adipose, and heart and skeletal muscle tissues in old and young female African green vervet monkeys. The genes associated with the development of inflammation, cardiovascular and skeletal disorder diseases, and cancer were revealed by the ICEGM. Meanwhile, genes in the ICEGM modules were also enriched in the adipocytes, smooth muscle cells, cardiac myocytes, and immune cells. Comprehensive disease annotation and canonical pathway analysis indicated that immune cells, adipocytes, cardiomyocytes, and smooth muscle cells played a synergistic role in cardiac and physical functions in the aged monkeys by regulation of the biological processes associated with metabolism, inflammation, and atherosclerosis. In conclusion, the ICEGM provides an efficiently systematic framework for decoding the co-expression gene modules in multiple tissues. Analysis of genes in the ICEGM module yielded important insights on the cooperative role of multiple tissues in the development of diseases. Safeguards Network Analysis Procedure (SNAP): overview Chapman, L.D; Engi, D. Nuclear safeguards systems provide physical protection and control of nuclear materials. The Safeguards Network Analysis Procedure (SNAP) provides a convenient and standard analysis methodology for the evaluation of physical protection system effectiveness. This is achieved through a standard set of symbols which characterize the various elements of safeguards systems and an analysis program to execute simulation models built using the SNAP symbology. The outputs provided by the SNAP simulation program supplements the safeguards analyst's evaluative capabilities and supports the evaluation of existing sites as well as alternative design possibilities. This paper describes the SNAP modeling technique and provides an example illustrating its use Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERÎ± and ERÎ². Emily Powell Full Text Available Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERÎ± and ERÎ², which elicit opposing roles in regulating proliferation: ERÎ± is proliferative while ERÎ² is anti-proliferative. Exogenous expression of ERÎ² in ERÎ±-positive cancer cell lines inhibits cell proliferation in response to estrogen and reduces xenografted tumor growth in vivo, suggesting that ERÎ² might oppose ERÎ±'s proliferative effects via formation of ERÎ±/Î² heterodimers. Despite biochemical and cellular evidence of ERÎ±/Î² heterodimer formation in cells co-expressing both receptors, the biological roles of the ERÎ±/Î² heterodimer remain to be elucidated. Here we report the identification of two phytoestrogens that selectively activate ERÎ±/Î² heterodimers at specific concentrations using a cell-based, two-step high throughput small molecule screen for ER transcriptional activity and ER dimer selectivity. Using ERÎ±/Î² heterodimer-selective ligands at defined concentrations, we demonstrate that ERÎ±/Î² heterodimers are growth inhibitory in breast and prostate cells which co-express the two ER isoforms. Furthermore, using Automated Quantitative Analysis (AQUA to examine nuclear expression of ERÎ± and ERÎ² in human breast tissue microarrays, we demonstrate that ERÎ± and ERÎ² are co-expressed in the same cells in breast tumors. The co-expression of ERÎ± and ERÎ² in the same cells supports the possibility of ERÎ±/Î² heterodimer formation at physio- and pathological conditions, further suggesting that targeting ERÎ±/Î² heterodimers might be a novel therapeutic approach to the treatment of cancers which co-express ERÎ± and ERÎ². Principal component analysis networks and algorithms Kong, Xiangyu; Duan, Zhansheng This book not only provides a comprehensive introduction to neural-based PCA methods in control science, but also presents many novel PCA algorithms and their extensions and generalizations, e.g., dual purpose, coupled PCA, GED, neural based SVD algorithms, etc. It also discusses in detail various analysis methods for the convergence, stabilizing, self-stabilizing property of algorithms, and introduces the deterministic discrete-time systems method to analyze the convergence of PCA/MCA algorithms. Readers should be familiar with numerical analysis and the fundamentals of statistics, such as the basics of least squares and stochastic algorithms. Although it focuses on neural networks, the book only presents their learning law, which is simply an iterative algorithm. Therefore, no a priori knowledge of neural networks is required. This book will be of interest and serve as a reference source to researchers and students in applied mathematics, statistics, engineering, and other related fields. Service network analysis for agricultural mental health Fuller Jeffrey D Full Text Available Abstract Background Farmers represent a subgroup of rural and remote communities at higher risk of suicide attributed to insecure economic futures, self-reliant cultures and poor access to health services. Early intervention models are required that tap into existing farming networks. This study describes service networks in rural shires that relate to the mental health needs of farming families. This serves as a baseline to inform service network improvements. Methods A network survey of mental health related links between agricultural support, health and other human services in four drought declared shires in comparable districts in rural New South Wales, Australia. Mental health links covered information exchange, referral recommendations and program development. Results 87 agencies from 111 (78% completed a survey. 79% indicated that two thirds of their clients needed assistance for mental health related problems. The highest mean number of interagency links concerned information exchange and the frequency of these links between sectors was monthly to three monthly. The effectiveness of agricultural support and health sector links were rated as less effective by the agricultural support sector than by the health sector (p Conclusion Aligning with agricultural agencies is important to build effective mental health service pathways to address the needs of farming populations. Work is required to ensure that these agricultural support agencies have operational and effective links to primary mental health care services. Network analysis provides a baseline to inform this work. With interventions such as local mental health training and joint service planning to promote network development we would expect to see over time an increase in the mean number of links, the frequency in which these links are used and the rated effectiveness of these links. Social network analysis: Presenting an underused method for nursing research. Parnell, James Michael; Robinson, Jennifer C This paper introduces social network analysis as a versatile method with many applications in nursing research. Social networks have been studied for years in many social science fields. The methods continue to advance but remain unknown to most nursing scholars. Discussion paper. English language and interpreted literature was searched from Ovid Healthstar, CINAHL, PubMed Central, Scopus and hard copy texts from 1965 - 2017. Social network analysis first emerged in nursing literature in 1995 and appears minimally through present day. To convey the versatility and applicability of social network analysis in nursing, hypothetical scenarios are presented. The scenarios are illustrative of three approaches to social network analysis and include key elements of social network research design. The methods of social network analysis are underused in nursing research, primarily because they are unknown to most scholars. However, there is methodological flexibility and epistemological versatility capable of supporting quantitative and qualitative research. The analytic techniques of social network analysis can add new insight into many areas of nursing inquiry, especially those influenced by cultural norms. Furthermore, visualization techniques associated with social network analysis can be used to generate new hypotheses. Social network analysis can potentially uncover findings not accessible through methods commonly used in nursing research. Social networks can be analysed based on individual-level attributes, whole networks and subgroups within networks. Computations derived from social network analysis may stand alone to answer a research question or incorporated as variables into robust statistical models. Â© 2018 John Wiley & Sons Ltd. Analysis of global gene expression in Brachypodium distachyon reveals extensive network plasticity in response to abiotic stress. Henry D Priest Full Text Available Brachypodium distachyon is a close relative of many important cereal crops. Abiotic stress tolerance has a significant impact on productivity of agriculturally important food and feedstock crops. Analysis of the transcriptome of Brachypodium after chilling, high-salinity, drought, and heat stresses revealed diverse differential expression of many transcripts. Weighted Gene Co-Expression Network Analysis revealed 22 distinct gene modules with specific profiles of expression under each stress. Promoter analysis implicated short DNA sequences directly upstream of module members in the regulation of 21 of 22 modules. Functional analysis of module members revealed enrichment in functional terms for 10 of 22 network modules. Analysis of condition-specific correlations between differentially expressed gene pairs revealed extensive plasticity in the expression relationships of gene pairs. Photosynthesis, cell cycle, and cell wall expression modules were down-regulated by all abiotic stresses. Modules which were up-regulated by each abiotic stress fell into diverse and unique gene ontology GO categories. This study provides genomics resources and improves our understanding of abiotic stress responses of Brachypodium. CATHENA 4. A thermalhydraulics network analysis code Aydemir, N.U.; Hanna, B.N. Canadian Algorithm for THErmalhydraulic Network Analysis (CATHENA) is a one-dimensional, non-equilibrium, two-phase, two fluid network analysis code that has been in use for over two decades by various groups in Canada and around the world. The objective of the present paper is to describe the design, application and future development plans for the CATHENA 4 thermalhydraulics network analysis code, which is a modernized version of the present frozen CATHENA 3 code. The new code is designed in modular form, using the Fortran 95 (F95) programming language. The semi-implicit numerical integration scheme of CATHENA 3 is re-written to implement a fully-implicit methodology using Newton's iterative solution scheme suitable for nonlinear equations. The closure relations, as a first step, have been converted from the existing CATHENA 3 implementation to F95 but modularized to achieve ease of maintenance. The paper presents the field equations, followed by a description of the Newton's scheme used. The finite-difference form of the field equations is given, followed by a discussion of convergence criteria. Two applications of CATHENA 4 are presented to demonstrate the temporal and spatial convergence of the new code for problems with known solutions or available experimental data. (author) Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimerâ€™s Disease Vinay Lanke Full Text Available Alzheimerâ€™s disease (AD is a neurodegenerative disorder contributing to rapid decline in cognitive function and ultimately dementia. Most cases of AD occur in elderly and later years. There is a growing need for understanding the relationship between aging and AD to identify shared and unique hallmarks associated with the disease in a region and cell-type specific manner. Although genomic studies on AD have been performed extensively, the molecular mechanism of disease progression is still not clear. The major objective of our study is to obtain a higher-order network-level understanding of aging and AD, and their relationship using the hippocampal gene expression profiles of young (20â€“50 years, aging (70â€“99 years, and AD (70â€“99 years. The hippocampus is vulnerable to damage at early stages of AD and altered neurogenesis in the hippocampus is linked to the onset of AD. We combined the weighted gene co-expression network and weighted proteinâ€“protein interaction network-level approaches to study the transition from young to aging to AD. The network analysis revealed the organization of co-expression network into functional modules that are cell-type specific in aging and AD. We found that modules associated with astrocytes, endothelial cells and microglial cells are upregulated and significantly correlate with both aging and AD. The modules associated with neurons, mitochondria and endoplasmic reticulum are downregulated and significantly correlate with AD than aging. The oligodendrocytes module does not show significant correlation with neither aging nor disease. Further, we identified aging- and AD-specific interactions/subnetworks by integrating the gene expression with a human proteinâ€“protein interaction network. We found dysregulation of genes encoding protein kinases (FYN, SYK, SRC, PKC, MAPK1, ephrin receptors and transcription factors (FOS, STAT3, CEBPB, MYC, NFKÎ², and EGR1 in AD. Further, we found genes that encode proteins Network value and optimum analysis on the mode of networked marketing in TV media Xiao Dongpo Full Text Available Purpose: With the development of the networked marketing in TV media, it is important to do the research on network value and optimum analysis in this field.Design/methodology/approach: According to the research on the mode of networked marketing in TV media and Correlation theory, the essence of media marketing is creating, spreading and transferring values. The Participants of marketing value activities are in network, and value activities proceed in networked form. Network capability is important to TV media marketing activities.Findings: This article raises the direction of research of analysis and optimization about network based on the mode of networked marketing in TV media by studying TV media marketing Development Mechanism , network analysis and network value structure. NIF ICCS network design and loading analysis Tietbohl, G; Bryant, R The National Ignition Facility (NIF) is housed within a large facility about the size of two football fields. The Integrated Computer Control System (ICCS) is distributed throughout this facility and requires the integration of about 40,000 control points and over 500 video sources. This integration is provided by approximately 700 control computers distributed throughout the NIF facility and a network that provides the communication infrastructure. A main control room houses a set of seven computer consoles providing operator access and control of the various distributed front-end processors (FEPs). There are also remote workstations distributed within the facility that allow provide operator console functions while personnel are testing and troubleshooting throughout the facility. The operator workstations communicate with the FEPs which implement the localized control and monitoring functions. There are different types of FEPs for the various subsystems being controlled. This report describes the design of the NIF ICCS network and how it meets the traffic loads that will are expected and the requirements of the Sub-System Design Requirements (SSDR's). This document supersedes the earlier reports entitled Analysis of the National Ignition Facility Network, dated November 6, 1996 and The National Ignition Facility Digital Video and Control Network, dated July 9, 1996. For an overview of the ICCS, refer to the document NIF Integrated Computer Controls System Description (NIF-3738) Distinguishing manipulated stocks via trading network analysis Sun, Xiao-Qian; Cheng, Xue-Qi; Shen, Hua-Wei; Wang, Zhao-Yang Manipulation is an important issue for both developed and emerging stock markets. For the study of manipulation, it is critical to analyze investor behavior in the stock market. In this paper, an analysis of the full transaction records of over a hundred stocks in a one-year period is conducted. For each stock, a trading network is constructed to characterize the relations among its investors. In trading networks, nodes represent investors and a directed link connects a stock seller to a buyer with the total trade size as the weight of the link, and the node strength is the sum of all edge weights of a node. For all these trading networks, we find that the node degree and node strength both have tails following a power-law distribution. Compared with non-manipulated stocks, manipulated stocks have a high lower bound of the power-law tail, a high average degree of the trading network and a low correlation between the price return and the seller-buyer ratio. These findings may help us to detect manipulated stocks. The Application of Social Network Analysis to Team Sports Lusher, Dean; Robins, Garry; Kremer, Peter This article reviews how current social network analysis might be used to investigate individual and group behavior in sporting teams. Social network analysis methods permit researchers to explore social relations between team members and their individual-level qualities simultaneously. As such, social network analysis can be seen as augmentingâ€¦ Analysis and visualization of citation networks Zhao, Dangzhi Citation analysis-the exploration of reference patterns in the scholarly and scientific literature-has long been applied in a number of social sciences to study research impact, knowledge flows, and knowledge networks. It has important information science applications as well, particularly in knowledge representation and in information retrieval.Recent years have seen a burgeoning interest in citation analysis to help address research, management, or information service issues such as university rankings, research evaluation, or knowledge domain visualization. This renewed and growing interest An Intelligent technical analysis using neural network Reza Raei Full Text Available Technical analysis has been one of the most popular methods for stock market predictions for the past few decades. There have been enormous technical analysis methods to study the behavior of stock market for different kinds of trading markets such as currency, commodity or stock. In this paper, we propose two different methods based on volume adjusted moving average and ease of movement for stock trading. These methods are used with and without generalized regression neural network methods and the results are compared with each other. The preliminary results on historical stock price of 20 firms indicate that there is no meaningful difference between various proposed models of this paper. The network researchers' network: A social network analysis of the IMP Group 1985-2006 Henneberg, Stephan C. M.; Ziang, Zhizhong; NaudÃ©, Peter The Industrial Marketing and Purchasing (IMP) Group is a network of academic researchers working in the area of business-to-business marketing. The group meets every year to discuss and exchange ideas, with a conference having been held every year since 1984 (there was no meeting in 1987......). In this paper, based upon the papers presented at the 22 conferences held to date, we undertake a Social Network Analysis in order to examine the degree of co-publishing that has taken place between this group of researchers. We identify the different components in this database, and examine the large main... Network-Based Isoform Quantification with RNA-Seq Data for Cancer Transcriptome Analysis. Wei Zhang Full Text Available High-throughput mRNA sequencing (RNA-Seq is widely used for transcript quantification of gene isoforms. Since RNA-Seq data alone is often not sufficient to accurately identify the read origins from the isoforms for quantification, we propose to explore protein domain-domain interactions as prior knowledge for integrative analysis with RNA-Seq data. We introduce a Network-based method for RNA-Seq-based Transcript Quantification (Net-RSTQ to integrate protein domain-domain interaction network with short read alignments for transcript abundance estimation. Based on our observation that the abundances of the neighboring isoforms by domain-domain interactions in the network are positively correlated, Net-RSTQ models the expression of the neighboring transcripts as Dirichlet priors on the likelihood of the observed read alignments against the transcripts in one gene. The transcript abundances of all the genes are then jointly estimated with alternating optimization of multiple EM problems. In simulation Net-RSTQ effectively improved isoform transcript quantifications when isoform co-expressions correlate with their interactions. qRT-PCR results on 25 multi-isoform genes in a stem cell line, an ovarian cancer cell line, and a breast cancer cell line also showed that Net-RSTQ estimated more consistent isoform proportions with RNA-Seq data. In the experiments on the RNA-Seq data in The Cancer Genome Atlas (TCGA, the transcript abundances estimated by Net-RSTQ are more informative for patient sample classification of ovarian cancer, breast cancer and lung cancer. All experimental results collectively support that Net-RSTQ is a promising approach for isoform quantification. Net-RSTQ toolbox is available at http://compbio.cs.umn.edu/Net-RSTQ/. Simultaneity Analysis In A Wireless Sensor Network MaloviÄ‡ Miodrag Full Text Available An original wireless sensor network for vibration measurements was designed. Its primary purpose is modal analysis of vibrations of large structures. A number of experiments have been performed to evaluate the system, with special emphasis on the influence of different effects on simultaneity of data acquired from remote nodes, which is essential for modal analysis. One of the issues is that quartz crystal oscillators, which provide time reading on the devices, are optimized for use in the room temperature and exhibit significant frequency variations if operated outside the 20â€“30Â°C range. Although much research was performed to optimize algorithms of synchronization in wireless networks, the subject of temperature fluctuations was not investigated and discussed in proportion to its significance. This paper describes methods used to evaluate data simultaneity and some algorithms suitable for its improvement in small to intermediate size ad-hoc wireless sensor networks exposed to varying temperatures often present in on-site civil engineering measurements. Different substrate regimes determine transcriptional profiles and gene co-expression in Methanosarcina barkeri (DSM 800) Lin, Qiang; Fang, X.; Ho, A.; Li, J.; Yan, X.; Tu, B.; Li, Ch.; Li, J.; Yao, M.; Li, X. RoÄ�. 101, Ä�. 19 (2017), s. 7303-7316 ISSN 0175-7598 Institutional support: RVO:60077344 Keywords : Methanosarcina barkeri substrate regimes * diversity * co-expression * ecological strategies Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 3.420, year: 2016 Co-expression of the C-terminal domain of Yersinia enterocolitica ... Home; Journals; Journal of Biosciences; Volume 40; Issue 1. Co-expression of the C-terminal domain of Yersinia enterocolitica invasin enhances the efficacy of classical swine-fever-vectored vaccine based on human adenovirus. Helin Li Pengbo Ning Zhi Lin Wulong Liang Kai Kang Lei He Yanming Zhang. Articles VolumeÂ ... The alterations in biochemical signaling of hippocampal network activity in the autism brain The alterations in biochemical signaling of hippocampal network activity in the autism brain The alterations in biochemical signaling of hippocampal network activity in the autism brain ç”°å…�; é»„ç»§äº‘; çŽ‹é”�; é™¶è“‰è“‰; å�¢åº”æ¢…; å»–ç¾Žå�Ž; é™†æ¥ æ¥ ; æ�Žé�™; èŠ¦å�š; éŸ©å³° Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and communication. However, the role of synaptic dysfunction during development of autism remains unclear. In the present study, we address the alterations of biochemical signaling in hippocampal network following induction of the autism in experimental animals. Here, the an- imal disease model and DNA array being used to investigate the differences in transcriptome or- ganization between autistic and normal brain by gene co--expression network analysis. Understanding resilience in industrial symbiosis networks: insights from network analysis. Chopra, Shauhrat S; Khanna, Vikas Industrial symbiotic networks are based on the principles of ecological systems where waste equals food, to develop synergistic networks. For example, industrial symbiosis (IS) at Kalundborg, Denmark, creates an exchange network of waste, water, and energy among companies based on contractual dependency. Since most of the industrial symbiotic networks are based on ad-hoc opportunities rather than strategic planning, gaining insight into disruptive scenarios is pivotal for understanding the balance of resilience and sustainability and developing heuristics for designing resilient IS networks. The present work focuses on understanding resilience as an emergent property of an IS network via a network-based approach with application to the Kalundborg Industrial Symbiosis (KIS). Results from network metrics and simulated disruptive scenarios reveal Asnaes power plant as the most critical node in the system. We also observe a decrease in the vulnerability of nodes and reduction in single points of failure in the system, suggesting an increase in the overall resilience of the KIS system from 1960 to 2010. Based on our findings, we recommend design strategies, such as increasing diversity, redundancy, and multi-functionality to ensure flexibility and plasticity, to develop resilient and sustainable industrial symbiotic networks. Copyright Â© 2014 Elsevier Ltd. All rights reserved. NATbox: a network analysis toolbox in R. Chavan, Shweta S; Bauer, Michael A; Scutari, Marco; Nagarajan, Radhakrishnan There has been recent interest in capturing the functional relationships (FRs) from high-throughput assays using suitable computational techniques. FRs elucidate the working of genes in concert as a system as opposed to independent entities hence may provide preliminary insights into biological pathways and signalling mechanisms. Bayesian structure learning (BSL) techniques and its extensions have been used successfully for modelling FRs from expression profiles. Such techniques are especially useful in discovering undocumented FRs, investigating non-canonical signalling mechanisms and cross-talk between pathways. The objective of the present study is to develop a graphical user interface (GUI), NATbox: Network Analysis Toolbox in the language R that houses a battery of BSL algorithms in conjunction with suitable statistical tools for modelling FRs in the form of acyclic networks from gene expression profiles and their subsequent analysis. NATbox is a menu-driven open-source GUI implemented in the R statistical language for modelling and analysis of FRs from gene expression profiles. It provides options to (i) impute missing observations in the given data (ii) model FRs and network structure from gene expression profiles using a battery of BSL algorithms and identify robust dependencies using a bootstrap procedure, (iii) present the FRs in the form of acyclic graphs for visualization and investigate its topological properties using network analysis metrics, (iv) retrieve FRs of interest from published literature. Subsequently, use these FRs as structural priors in BSL (v) enhance scalability of BSL across high-dimensional data by parallelizing the bootstrap routines. NATbox provides a menu-driven GUI for modelling and analysis of FRs from gene expression profiles. By incorporating readily available functions from existing R-packages, it minimizes redundancy and improves reproducibility, transparency and sustainability, characteristic of open-source environments A flood-based information flow analysis and network minimization method for gene regulatory networks. Pavlogiannis, Andreas; Mozhayskiy, Vadim; Tagkopoulos, Ilias Biological networks tend to have high interconnectivity, complex topologies and multiple types of interactions. This renders difficult the identification of sub-networks that are involved in condition- specific responses. In addition, we generally lack scalable methods that can reveal the information flow in gene regulatory and biochemical pathways. Doing so will help us to identify key participants and paths under specific environmental and cellular context. This paper introduces the theory of network flooding, which aims to address the problem of network minimization and regulatory information flow in gene regulatory networks. Given a regulatory biological network, a set of source (input) nodes and optionally a set of sink (output) nodes, our task is to find (a) the minimal sub-network that encodes the regulatory program involving all input and output nodes and (b) the information flow from the source to the sink nodes of the network. Here, we describe a novel, scalable, network traversal algorithm and we assess its potential to achieve significant network size reduction in both synthetic and E. coli networks. Scalability and sensitivity analysis show that the proposed method scales well with the size of the network, and is robust to noise and missing data. The method of network flooding proves to be a useful, practical approach towards information flow analysis in gene regulatory networks. Further extension of the proposed theory has the potential to lead in a unifying framework for the simultaneous network minimization and information flow analysis across various "omics" levels. An integrative computational analysis provides evidence for FBN1-associated network deregulation in trisomy 21 Mireia Vilardell Although approximately 50% of Down Syndrome (DS patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. A recent study reported a case of a person affected by DS who carried mutations in FBN1, the gene causative for a connective tissue disorder called Marfan Syndrome (MFS. The fact that the person did not have any cardiac alterations suggested compensation effects due to DS. This observation is supported by a previous DS meta-analysis at the molecular level where we have found an overall upregulation of FBN1 (which is usually downregulated in MFS. Additionally, that result was cross-validated with independent expression data from DS heart tissue. The aim of this work is to elucidate the role of FBN1 in DS and to establish a molecular link to MFS and MFS-related syndromes using a computational approach. To reach that, we conducted different analytical approaches over two DS studies (our previous meta-analysis and independent expression data from DS heart tissue and revealed expression alterations in the FBN1 interaction network, in FBN1 co-expressed genes and FBN1-related pathways. After merging the significant results from different datasets with a Bayesian approach, we prioritized 85 genes that were able to distinguish control from DS cases. We further found evidence for several of these genes (47%, such as FBN1, DCN, and COL1A2, being dysregulated in MFS and MFS-related diseases. Consequently, we further encourage the scientific community to take into account FBN1 and its related network for the study of DS cardiovascular characteristics. Applications of social media and social network analysis Kazienko, Przemyslaw This collection of contributed chapters demonstrates a wide range of applications within two overlapping research domains: social media analysis and social network analysis. Various methodologies were utilized in the twelve individual chapters including static, dynamic and real-time approaches to graph, textual and multimedia data analysis. The topics apply to reputation computation, emotion detection, topic evolution, rumor propagation, evaluation of textual opinions, friend ranking, analysis of public transportation networks, diffusion in dynamic networks, analysis of contributors to commun Analysis of complex systems using neural networks Uhrig, R.E. The application of neural networks, alone or in conjunction with other advanced technologies (expert systems, fuzzy logic, and/or genetic algorithms), to some of the problems of complex engineering systems has the potential to enhance the safety, reliability, and operability of these systems. Typically, the measured variables from the systems are analog variables that must be sampled and normalized to expected peak values before they are introduced into neural networks. Often data must be processed to put it into a form more acceptable to the neural network (e.g., a fast Fourier transformation of the time-series data to produce a spectral plot of the data). Specific applications described include: (1) Diagnostics: State of the Plant (2) Hybrid System for Transient Identification, (3) Sensor Validation, (4) Plant-Wide Monitoring, (5) Monitoring of Performance and Efficiency, and (6) Analysis of Vibrations. Although specific examples described deal with nuclear power plants or their subsystems, the techniques described can be applied to a wide variety of complex engineering systems Network-based analysis of proteomic profiles Wong, Limsoon Mass spectrometry (MS)-based proteomics is a widely used and powerful tool for profiling systems-wide protein expression changes. It can be applied for various purposes, e.g. biomarker discovery in diseases and study of drug responses. Although RNA-based high-throughput methods have been useful in providing glimpses into the underlying molecular processes, the evidences they provide are indirect. Furthermore, RNA and corresponding protein levels have been known to have poor correlation. On the other hand, MS-based proteomics tend to have consistency issues (poor reproducibility and inter-sample agreement) and coverage issues (inability to detect the entire proteome) that need to be urgently addressed. In this talk, I will discuss how these issues can be addressed by proteomic profile analysis techniques that use biological networks (especially protein complexes) as the biological context. In particular, I will describe several techniques that we have been developing for network-based analysis of proteomics profile. And I will present evidence that these techniques are useful in identifying proteomics-profile analysis results that are more consistent, more reproducible, and more biologically coherent, and that these techniques allow expansion of the detected proteome to uncover and/or discover novel proteins. Social sciences via network analysis and computation Kanduc, Tadej In recent years information and communication technologies have gained significant importance in the social sciences. Because there is such rapid growth of knowledge, methods and computer infrastructure, research can now seamlessly connect interdisciplinary fields such as business process management, data processing and mathematics. This study presents some of the latest results, practices and state-of-the-art approaches in network analysis, machine learning, data mining, data clustering and classifications in the contents of social sciences. It also covers various real-life examples such as t Analysis of Time Delay Simulation in Networked Control System Nyan Phyo Aung; Zaw Min Naing; Hla Myo Tun The paper presents a PD controller for the Networked Control Systems (NCS) with delay. The major challenges in this networked control system (NCS) are the delay of the data transmission throughout the communication network. The comparative performance analysis is carried out for different delays network medium. In this paper, simulation is carried out on Ac servo motor control system using CAN Bus as communication network medium. The True Time toolbox of MATLAB is used for simulation to analy... Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment. Uddin, Raihan; Singh, Shiva M As humans age many suffer from a decrease in normal brain functions including spatial learning impairments. This study aimed to better understand the molecular mechanisms in age-associated spatial learning impairment (ASLI). We used a mathematical modeling approach implemented in Weighted Gene Co-expression Network Analysis (WGCNA) to create and compare gene network models of young (learning unimpaired) and aged (predominantly learning impaired) brains from a set of exploratory datasets in rats in the context of ASLI. The major goal was to overcome some of the limitations previously observed in the traditional meta- and pathway analysis using these data, and identify novel ASLI related genes and their networks based on co-expression relationship of genes. This analysis identified a set of network modules in the young, each of which is highly enriched with genes functioning in broad but distinct GO functional categories or biological pathways. Interestingly, the analysis pointed to a single module that was highly enriched with genes functioning in "learning and memory" related functions and pathways. Subsequent differential network analysis of this "learning and memory" module in the aged (predominantly learning impaired) rats compared to the young learning unimpaired rats allowed us to identify a set of novel ASLI candidate hub genes. Some of these genes show significant repeatability in networks generated from independent young and aged validation datasets. These hub genes are highly co-expressed with other genes in the network, which not only show differential expression but also differential co-expression and differential connectivity across age and learning impairment. The known function of these hub genes indicate that they play key roles in critical pathways, including kinase and phosphatase signaling, in functions related to various ion channels, and in maintaining neuronal integrity relating to synaptic plasticity and memory formation. Taken together, they Models as Tools of Analysis of a Network Organisation Wojciech PajÄ…k Full Text Available The paper presents models which may be applied as tools of analysis of a network organisation. The starting point of the discussion is defining the following terms: supply chain and network organisation. Further parts of the paper present basic assumptions analysis of a network organisation. Then the study characterises the best known models utilised in analysis of a network organisation. The purpose of the article is to define the notion and the essence of network organizations and to present the models used for their analysis. Spatial analysis of bus transport networks using network theory Shanmukhappa, Tanuja; Ho, Ivan Wang-Hei; Tse, Chi Kong In this paper, we analyze the bus transport network (BTN) structure considering the spatial embedding of the network for three cities, namely, Hong Kong (HK), London (LD), and Bengaluru (BL). We propose a novel approach called supernode graph structuring for modeling the bus transport network. A static demand estimation procedure is proposed to assign the node weights by considering the points of interests (POIs) and the population distribution in the city over various localized zones. In addition, the end-to-end delay is proposed as a parameter to measure the topological efficiency of the bus networks instead of the shortest distance measure used in previous works. With the aid of supernode graph representation, important network parameters are analyzed for the directed, weighted and geo-referenced bus transport networks. It is observed that the supernode concept has significant advantage in analyzing the inherent topological behavior. For instance, the scale-free and small-world behavior becomes evident with supernode representation as compared to conventional or regular graph representation for the Hong Kong network. Significant improvement in clustering, reduction in path length, and increase in centrality values are observed in all the three networks with supernode representation. The correlation between topologically central nodes and the geographically central nodes reveals the interesting fact that the proposed static demand estimation method for assigning node weights aids in better identifying the geographically significant nodes in the network. The impact of these geographically significant nodes on the local traffic behavior is demonstrated by simulation using the SUMO (Simulation of Urban Mobility) tool which is also supported by real-world empirical data, and our results indicate that the traffic speed around a particular bus stop can reach a jammed state from a free flow state due to the presence of these geographically important nodes. A comparison A comprehensive probabilistic analysis model of oil pipelines network based on Bayesian network Zhang, C.; Qin, T. X.; Jiang, B.; Huang, C. Oil pipelines network is one of the most important facilities of energy transportation. But oil pipelines network accident may result in serious disasters. Some analysis models for these accidents have been established mainly based on three methods, including event-tree, accident simulation and Bayesian network. Among these methods, Bayesian network is suitable for probabilistic analysis. But not all the important influencing factors are considered and the deployment rule of the factors has not been established. This paper proposed a probabilistic analysis model of oil pipelines network based on Bayesian network. Most of the important influencing factors, including the key environment condition and emergency response are considered in this model. Moreover, the paper also introduces a deployment rule for these factors. The model can be used in probabilistic analysis and sensitive analysis of oil pipelines network accident. Robustness Analysis of Real Network Topologies Under Multiple Failure Scenarios Manzano, M.; Marzo, J. L.; Calle, E. on topological characteristics. Recently approaches also consider the services supported by such networks. In this paper we carry out a robustness analysis of five real backbone telecommunication networks under defined multiple failure scenarios, taking into account the consequences of the loss of established......Nowadays the ubiquity of telecommunication networks, which underpin and fulfill key aspects of modern day living, is taken for granted. Significant large-scale failures have occurred in the last years affecting telecommunication networks. Traditionally, network robustness analysis has been focused...... connections. Results show which networks are more robust in response to a specific type of failure.... Identifying changes in the support networks of end-of-life carers using social network analysis. Leonard, Rosemary; Horsfall, Debbie; Noonan, Kerrie End-of-life caring is often associated with reduced social networks for both the dying person and for the carer. However, those adopting a community participation and development approach, see the potential for the expansion and strengthening of networks. This paper uses Knox, Savage and Harvey's definitions of three generations social network analysis to analyse the caring networks of people with a terminal illness who are being cared for at home and identifies changes in these caring networks that occurred over the period of caring. Participatory network mapping of initial and current networks was used in nine focus groups. The analysis used key concepts from social network analysis (size, density, transitivity, betweenness and local clustering) together with qualitative analyses of the group's reflections on the maps. The results showed an increase in the size of the networks and that ties between the original members of the network strengthened. The qualitative data revealed the importance between core and peripheral network members and the diverse contributions of the network members. The research supports the value of third generation social network analysis and the potential for end-of-life caring to build social capital. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. CoNekT: an open-source framework for comparative genomic and transcriptomic network analyses. Proost, Sebastian; Mutwil, Marek The recent accumulation of gene expression data in the form of RNA sequencing creates unprecedented opportunities to study gene regulation and function. Furthermore, comparative analysis of the expression data from multiple species can elucidate which functional gene modules are conserved across species, allowing the study of the evolution of these modules. However, performing such comparative analyses on raw data is not feasible for many biologists. Here, we present CoNekT (Co-expression Network Toolkit), an open source web server, that contains user-friendly tools and interactive visualizations for comparative analyses of gene expression data and co-expression networks. These tools allow analysis and cross-species comparison of (i) gene expression profiles; (ii) co-expression networks; (iii) co-expressed clusters involved in specific biological processes; (iv) tissue-specific gene expression; and (v) expression profiles of gene families. To demonstrate these features, we constructed CoNekT-Plants for green alga, seed plants and flowering plants (Picea abies, Chlamydomonas reinhardtii, Vitis vinifera, Arabidopsis thaliana, Oryza sativa, Zea mays and Solanum lycopersicum) and thus provide a web-tool with the broadest available collection of plant phyla. CoNekT-Plants is freely available from http://conekt.plant.tools, while the CoNekT source code and documentation can be found at https://github.molgen.mpg.de/proost/CoNekT/. Dissecting the seed-to-seedling transition in Arabidopsis thaliana by gene co-expression networks Silva, A.T. One of the most important developmental processes in the life-cycle of higher plants is the transition from a seed to a plant and from a generative to a vegetative developmental program. The major hallmark or end-point of the transition from seed to plant is the onset of photosynthesis and the Spectral Analysis Methods of Social Networks P. G. Klyucharev Full Text Available Online social networks (such as Facebook, Twitter, VKontakte, etc. being an important channel for disseminating information are often used to arrange an impact on the social consciousness for various purposes - from advertising products or services to the full-scale information war thereby making them to be a very relevant object of research. The paper reviewed the analysis methods of social networks (primarily, online, based on the spectral theory of graphs. Such methods use the spectrum of the social graph, i.e. a set of eigenvalues of its adjacency matrix, and also the eigenvectors of the adjacency matrix.Described measures of centrality (in particular, centrality based on the eigenvector and PageRank, which reflect a degree of impact one or another user of the social network has. A very popular PageRank measure uses, as a measure of centrality, the graph vertices, the final probabilities of the Markov chain, whose matrix of transition probabilities is calculated on the basis of the adjacency matrix of the social graph. The vector of final probabilities is an eigenvector of the matrix of transition probabilities.Presented a method of dividing the graph vertices into two groups. It is based on maximizing the network modularity by computing the eigenvector of the modularity matrix.Considered a method for detecting bots based on the non-randomness measure of a graph to be computed using the spectral coordinates of vertices - sets of eigenvector components of the adjacency matrix of a social graph.In general, there are a number of algorithms to analyse social networks based on the spectral theory of graphs. These algorithms show very good results, but their disadvantage is the relatively high (albeit polynomial computational complexity for large graphs.At the same time it is obvious that the practical application capacity of the spectral graph theory methods is still underestimated, and it may be used as a basis to develop new methods.The work Understanding Classrooms through Social Network Analysis: A Primer for Social Network Analysis in Education Research Grunspan, Daniel Z.; Wiggins, Benjamin L.; Goodreau, Steven M. Social interactions between students are a major and underexplored part of undergraduate education. Understanding how learning relationships form in undergraduate classrooms, as well as the impacts these relationships have on learning outcomes, can inform educators in unique ways and improve educational reform. Social network analysis (SNA)â€¦ Network-directed cis-mediator analysis of normal prostate tissue expression profiles reveals downstream regulatory associations of prostate cancer susceptibility loci. Larson, Nicholas B; McDonnell, Shannon K; Fogarty, Zach; Larson, Melissa C; Cheville, John; Riska, Shaun; Baheti, Saurabh; Weber, Alexandra M; Nair, Asha A; Wang, Liang; O'Brien, Daniel; Davila, Jaime; Schaid, Daniel J; Thibodeau, Stephen N Large-scale genome-wide association studies have identified multiple single-nucleotide polymorphisms associated with risk of prostate cancer. Many of these genetic variants are presumed to be regulatory in nature; however, follow-up expression quantitative trait loci (eQTL) association studies have to-date been restricted largely to cis -acting associations due to study limitations. While trans -eQTL scans suffer from high testing dimensionality, recent evidence indicates most trans -eQTL associations are mediated by cis -regulated genes, such as transcription factors. Leveraging a data-driven gene co-expression network, we conducted a comprehensive cis -mediator analysis using RNA-Seq data from 471 normal prostate tissue samples to identify downstream regulatory associations of previously identified prostate cancer risk variants. We discovered multiple trans -eQTL associations that were significantly mediated by cis -regulated transcripts, four of which involved risk locus 17q12, proximal transcription factor HNF1B , and target trans -genes with known HNF response elements ( MIA2 , SRC , SEMA6A , KIF12 ). We additionally identified evidence of cis -acting down-regulation of MSMB via rs10993994 corresponding to reduced co-expression of NDRG1 . The majority of these cis -mediator relationships demonstrated trans -eQTL replicability in 87 prostate tissue samples from the Gene-Tissue Expression Project. These findings provide further biological context to known risk loci and outline new hypotheses for investigation into the etiology of prostate cancer. The Use of RNA Sequencing and Correlation Network Analysis to Study Potential Regulators of Crabapple Leaf Color Transformation. Yang, Tuo; Li, Keting; Hao, Suxiao; Zhang, Jie; Song, Tingting; Tian, Ji; Yao, Yuncong Anthocyanins are plant pigments that contribute to the color of leaves, flowers and fruits, and that are beneficial to human health in the form of dietary antioxidants. The study of a transformable crabapple cultivar, 'India magic', which has red buds and green mature leaves, using mRNA profiling of four leaf developmental stages, allowed us to characterize molecular mechanisms regulating red color formation in early leaf development and the subsequent rapid down-regulation of anthocyanin biosynthesis. This analysis of differential gene expression during leaf development revealed that ethylene signaling-responsive genes are up-regulated during leaf pigmentation. Genes in the ethylene response factor (ERF), SPL, NAC, WRKY and MADS-box transcription factor (TF) families were identified in two weighted gene co-expression network analysis (WGCNA) modules as having a close relationship to anthocyanin accumulation. Analyses of network hub genes indicated that SPL TFs are located in central positions within anthocyanin-related modules. Furthermore, cis-motif and yeast one-hybrid assays suggested that several anthocyanin biosynthetic or regulatory genes are potential targets of SPL8 and SPL13B. Transient silencing of these two genes confirmed that they play a role in co-ordinating anthocyanin biosynthesis and crabapple leaf development. We present a high-resolution method for identifying regulatory modules associated with leaf pigmentation, which provides a platform for functional genomic studies of anthocyanin biosynthesis. ConGEMs: Condensed Gene Co-Expression Module Discovery Through Rule-Based Clustering and Its Application to Carcinogenesis Saurav Mallik Full Text Available For transcriptomic analysis, there are numerous microarray-based genomic data, especially those generated for cancer research. The typical analysis measures the difference between a cancer sample-group and a matched control group for each transcript or gene. Association rule mining is used to discover interesting item sets through rule-based methodology. Thus, it has advantages to find causal effect relationships between the transcripts. In this work, we introduce two new rule-based similarity measuresâ€”weighted rank-based Jaccard and Cosine measuresâ€”and then propose a novel computational framework to detect condensed gene co-expression modules ( C o n G E M s through the association rule-based learning system and the weighted similarity scores. In practice, the list of evolved condensed markers that consists of both singular and complex markers in nature depends on the corresponding condensed gene sets in either antecedent or consequent of the rules of the resultant modules. In our evaluation, these markers could be supported by literature evidence, KEGG (Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology annotations. Specifically, we preliminarily identified differentially expressed genes using an empirical Bayes test. A recently developed algorithmâ€”RANWARâ€”was then utilized to determine the association rules from these genes. Based on that, we computed the integrated similarity scores of these rule-based similarity measures between each rule-pair, and the resultant scores were used for clustering to identify the co-expressed rule-modules. We applied our method to a gene expression dataset for lung squamous cell carcinoma and a genome methylation dataset for uterine cervical carcinogenesis. Our proposed module discovery method produced better results than the traditional gene-module discovery measures. In summary, our proposed rule-based method is useful for exploring biomarker modules from transcriptomic data. ConGEMs: Condensed Gene Co-Expression Module Discovery Through Rule-Based Clustering and Its Application to Carcinogenesis. Mallik, Saurav; Zhao, Zhongming For transcriptomic analysis, there are numerous microarray-based genomic data, especially those generated for cancer research. The typical analysis measures the difference between a cancer sample-group and a matched control group for each transcript or gene. Association rule mining is used to discover interesting item sets through rule-based methodology. Thus, it has advantages to find causal effect relationships between the transcripts. In this work, we introduce two new rule-based similarity measures-weighted rank-based Jaccard and Cosine measures-and then propose a novel computational framework to detect condensed gene co-expression modules ( C o n G E M s) through the association rule-based learning system and the weighted similarity scores. In practice, the list of evolved condensed markers that consists of both singular and complex markers in nature depends on the corresponding condensed gene sets in either antecedent or consequent of the rules of the resultant modules. In our evaluation, these markers could be supported by literature evidence, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and Gene Ontology annotations. Specifically, we preliminarily identified differentially expressed genes using an empirical Bayes test. A recently developed algorithm-RANWAR-was then utilized to determine the association rules from these genes. Based on that, we computed the integrated similarity scores of these rule-based similarity measures between each rule-pair, and the resultant scores were used for clustering to identify the co-expressed rule-modules. We applied our method to a gene expression dataset for lung squamous cell carcinoma and a genome methylation dataset for uterine cervical carcinogenesis. Our proposed module discovery method produced better results than the traditional gene-module discovery measures. In summary, our proposed rule-based method is useful for exploring biomarker modules from transcriptomic data. Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas Aaberg-Jessen, Charlotte; SÃ¸rensen, Mia D.; Matos, Ana L.S.A. scoring. CD63 expression in tumor-associated microglia/macrophages was examined by double-immunofluorescence with ionized calcium-binding adapter molecule 1 (Iba1). The association between CD63 and TIMP-1 was investigated using previously obtained TIMP-1 data from our astrocytoma cohort. Cellular co-expression...... of CD63 was widely distributed in astrocytomas with a significantly increased level in glioblastomas. CD63 levels did not significantly correlate with patient survival at a protein level, and CD63 did not augment the prognostic significance of TIMP-1. Up to 38% of the CD63+ cells expressed Iba1; however......, Iba1 did not appear to impact the prognostic value of CD63. A significant correlation was found between TIMP-1 and CD63, and the TIMP-1 and CD63 proteins were co-expressed at the cellular level and located in close molecular proximity, suggesting that TIMP-1 and CD63 could be co... Analysis and monitoring design for networks Fedorov, V.; Flanagan, D.; Rowan, T.; Batsell, S. The idea of applying experimental design methodologies to develop monitoring systems for computer networks is relatively novel even though it was applied in other areas such as meteorology, seismology, and transportation. One objective of a monitoring system should always be to collect as little data as necessary to be able to monitor specific parameters of the system with respect to assigned targets and objectives. This implies a purposeful monitoring where each piece of data has a reason to be collected and stored for future use. When a computer network system as large and complex as the Internet is the monitoring subject, providing an optimal and parsimonious observing system becomes even more important. Many data collection decisions must be made by the developers of a monitoring system. These decisions include but are not limited to the following: (1) The type data collection hardware and software instruments to be used; (2) How to minimize interruption of regular network activities during data collection; (3) Quantification of the objectives and the formulation of optimality criteria; (4) The placement of data collection hardware and software devices; (5) The amount of data to be collected in a given time period, how large a subset of the available data to collect during the period, the length of the period, and the frequency of data collection; (6) The determination of the data to be collected (for instance, selection of response and explanatory variables); (7) Which data will be retained and how long (i.e., data storage and retention issues); and (8) The cost analysis of experiments. Mathematical statistics, and, in particular, optimal experimental design methods, may be used to address the majority of problems generated by 3--7. In this study, the authors focus their efforts on topics 3--5. Characterization of chemically induced liver injuries using gene co-expression modules. Gregory J Tawa Full Text Available Liver injuries due to ingestion or exposure to chemicals and industrial toxicants pose a serious health risk that may be hard to assess due to a lack of non-invasive diagnostic tests. Mapping chemical injuries to organ-specific damage and clinical outcomes via biomarkers or biomarker panels will provide the foundation for highly specific and robust diagnostic tests. Here, we have used DrugMatrix, a toxicogenomics database containing organ-specific gene expression data matched to dose-dependent chemical exposures and adverse clinical pathology assessments in Sprague Dawley rats, to identify groups of co-expressed genes (modules specific to injury endpoints in the liver. We identified 78 such gene co-expression modules associated with 25 diverse injury endpoints categorized from clinical pathology, organ weight changes, and histopathology. Using gene expression data associated with an injury condition, we showed that these modules exhibited different patterns of activation characteristic of each injury. We further showed that specific module genes mapped to 1 known biochemical pathways associated with liver injuries and 2 clinically used diagnostic tests for liver fibrosis. As such, the gene modules have characteristics of both generalized and specific toxic response pathways. Using these results, we proposed three gene signature sets characteristic of liver fibrosis, steatosis, and general liver injury based on genes from the co-expression modules. Out of all 92 identified genes, 18 (20% genes have well-documented relationships with liver disease, whereas the rest are novel and have not previously been associated with liver disease. In conclusion, identifying gene co-expression modules associated with chemically induced liver injuries aids in generating testable hypotheses and has the potential to identify putative biomarkers of adverse health effects. 6th International Conference on Network Analysis Nikolaev, Alexey; Pardalos, Panos; Prokopyev, Oleg This valuable source for graduate students and researchers provides a comprehensive introduction to current theories and applications in optimization methods and network models. Contributions to this book are focused on new efficient algorithms and rigorous mathematical theories, which can be used to optimize and analyze mathematical graph structures with massive size and high density induced by natural or artificial complex networks. Applications to social networks, power transmission grids, telecommunication networks, stock market networks, and human brain networks are presented. Chapters in this book cover the following topics: Linear max min fairness Heuristic approaches for high-quality solutions Efficient approaches for complex multi-criteria optimization problems Comparison of heuristic algorithms New heuristic iterative local search Power in network structures Clustering nodes in random graphs Power transmission grid structure Network decomposition problems Homogeneity hypothesis testing Network analy... Artificial neural network for violation analysis Zhang, Z.; Polet, P.; Vanderhaegen, F.; Millot, P. Barrier removal (BR) is a safety-related violation, and it can be analyzed in terms of benefits, costs, and potential deficits. In order to allow designers to integrate BR into the risk analysis during the initial design phase or during re-design work, we propose a connectionist method integrating self-organizing maps (SOM). The basic SOM is an artificial neural network that, on the basis of the information contained in a multi-dimensional space, generates a space of lesser dimensions. Three algorithms--Unsupervised SOM, Supervised SOM, and Hierarchical SOM--have been developed to permit BR classification and prediction in terms of the different criteria. The proposed method can be used, on the one hand, to foresee/predict the possibility level of a new/changed barrier (prospective analysis), and on the other hand, to synthetically regroup/rearrange the BR of a given human-machine system (retrospective analysis). We applied this method to the BR analysis of an experimental railway simulator, and our preliminary results are presented here The Design and Analysis of Virtual Network Configuration for a Wireless Mobile ATM Network Bush, Stephen F. This research concentrates on the design and analysis of an algorithm referred to as Virtual Network Configuration (VNC) which uses predicted future states of a system for faster network configuration and management. VNC is applied to the configuration of a wireless mobile ATM network. VNC is built on techniques from parallel discrete event simulation merged with constraints from real-time systems and applied to mobile ATM configuration and handoff. Configuration in a mobile network is a dyna... Analysis of robustness of urban bus network Tao, Ren; Yi-Fan, Wang; Miao-Miao, Liu; Yan-Jie, Xu In this paper, the invulnerability and cascade failures are discussed for the urban bus network. Firstly, three static models(bus stop network, bus transfer network, and bus line network) are used to analyse the structure and invulnerability of urban bus network in order to understand the features of bus network comprehensively. Secondly, a new way is proposed to study the invulnerability of urban bus network by modelling two layered networks, i.e., the bus stop-line network and the bus line-transfer network and then the interactions between different models are analysed. Finally, by modelling a new layered network which can reflect the dynamic passenger flows, the cascade failures are discussed. Then a new load redistribution method is proposed to study the robustness of dynamic traffic. In this paper, the bus network of Shenyang City which is one of the biggest cities in China, is taken as a simulation example. In addition, some suggestions are given to improve the urban bus network and provide emergency strategies when traffic congestion occurs according to the numerical simulation results. Project supported by the National Natural Science Foundation of China (Grant Nos. 61473073, 61374178, 61104074, and 61203329), the Fundamental Research Funds for the Central Universities (Grant Nos. N130417006, L1517004), and the Program for Liaoning Excellent Talents in University (Grant No. LJQ2014028). Method and tool for network vulnerability analysis Swiler, Laura Painton [Albuquerque, NM; Phillips, Cynthia A [Albuquerque, NM A computer system analysis tool and method that will allow for qualitative and quantitative assessment of security attributes and vulnerabilities in systems including computer networks. The invention is based on generation of attack graphs wherein each node represents a possible attack state and each edge represents a change in state caused by a single action taken by an attacker or unwitting assistant. Edges are weighted using metrics such as attacker effort, likelihood of attack success, or time to succeed. Generation of an attack graph is accomplished by matching information about attack requirements (specified in "attack templates") to information about computer system configuration (contained in a configuration file that can be updated to reflect system changes occurring during the course of an attack) and assumed attacker capabilities (reflected in "attacker profiles"). High risk attack paths, which correspond to those considered suited to application of attack countermeasures given limited resources for applying countermeasures, are identified by finding "epsilon optimal paths." Network-Based Visual Analysis of Tabular Data Liu, Zhicheng Tabular data is pervasive in the form of spreadsheets and relational databases. Although tables often describe multivariate data without explicit network semantics, it may be advantageous to explore the data modeled as a graph or network for analysis. Even when a given table design conveys some static network semantics, analysts may want to lookâ€¦ Analysis of Computer Network Information Based on "Big Data" Li, Tianli With the development of the current era, computer network and large data gradually become part of the people's life, people use the computer to provide convenience for their own life, but at the same time there are many network information problems has to pay attention. This paper analyzes the information security of computer network based on "big data" analysis, and puts forward some solutions. Road Transport Network Analysis In Port-Harcourt Metropolics ... Road transport network contributes to the economy of an area as it connects points of origin to destinations. The thrust of this article therefore, is on the analysis of the road networks in Port â€“ Harcourt metropolis with the aim of determining the connectivity of the road networks and the most accessible node. ConsequentlyÂ ... Analysis of Municipal Pipe Network Franchise Institution Yong, Sun; Haichuan, Tian; Feng, Xu; Huixia, Zhou Franchise institution of municipal pipe network has some particularity due to the characteristic of itself. According to the exposition of Chinese municipal pipe network industry franchise institution, the article investigates the necessity of implementing municipal pipe network franchise institution in China, the role of government in the process and so on. And this offers support for the successful implementation of municipal pipe network franchise institution in China. Advanced functional network analysis in the geosciences: The pyunicorn package Donges, Jonathan F.; Heitzig, Jobst; Runge, Jakob; Schultz, Hanna C. H.; Wiedermann, Marc; Zech, Alraune; Feldhoff, Jan; Rheinwalt, Aljoscha; Kutza, Hannes; Radebach, Alexander; Marwan, Norbert; Kurths, JÃ¼rgen Functional networks are a powerful tool for analyzing large geoscientific datasets such as global fields of climate time series originating from observations or model simulations. pyunicorn (pythonic unified complex network and recurrence analysis toolbox) is an open-source, fully object-oriented and easily parallelizable package written in the language Python. It allows for constructing functional networks (aka climate networks) representing the structure of statistical interrelationships in large datasets and, subsequently, investigating this structure using advanced methods of complex network theory such as measures for networks of interacting networks, node-weighted statistics or network surrogates. Additionally, pyunicorn allows to study the complex dynamics of geoscientific systems as recorded by time series by means of recurrence networks and visibility graphs. The range of possible applications of the package is outlined drawing on several examples from climatology. Analysis of neural networks through base functions van der Zwaag, B.J.; Slump, Cornelis H.; Spaanenburg, L. Problem statement. Despite their success-story, neural networks have one major disadvantage compared to other techniques: the inability to explain comprehensively how a trained neural network reaches its output; neural networks are not only (incorrectly) seen as a "magic tool" but possibly even more Synchronization analysis of coloured delayed networks under ... This paper investigates synchronization of coloured delayed networks under decentralized pinning intermittent control. To begin with, the time delays are taken into account in the coloured networks. In addition, we propose a decentralized pinning intermittent control for coloured delayed networks, which is different from thatÂ ... A Social Network Analysis of Occupational Segregation Buhai, Ioan Sebastian; van der Leij, Marco We develop a social network model of occupational segregation between different social groups, generated by the existence of positive inbreeding bias among individuals from the same group. If network referrals are important for job search, then expected homophily in the contact network structure... Pareto distance for multi-layer network analysis Magnani, Matteo; Rossi, Luca services, e.g., Facebook, Twitter, LinkedIn and Foursquare. As a result, the analysis of on-line social networks requires a wider scope and, more technically speaking, models for the representation of this fragmented scenario. The recent introduction of more realistic layered models has however determined......Social Network Analysis has been historically applied to single networks, e.g., interaction networks between co-workers. However, the advent of on-line social network sites has emphasized the stratified structure of our social experience. Individuals usually spread their identities over multiple... An asymptotic analysis of closed queueing networks with branching populations Bayer, N.; Coffman, E.G.; Kogan, Y.A. textabstractClosed queueing networks have proven to be valuable tools for system performance analysis. In this paper, we broaden the applications of such networks by incorporating populations of {em branching customers: whenever a customer completes service at some node of the network, it is replaced by N>=0 customers, each routed independently to a next node, where N has a given, possibly node-dependent branching distribution. Applications of these branching and queueing networks focus on {e... Data Farming Process and Initial Network Analysis Capabilities Gary Horne Full Text Available Data Farming, network applications and approaches to integrate network analysis and processes to the data farming paradigm are presented as approaches to address complex system questions. Data Farming is a quantified approach that examines questions in large possibility spaces using modeling and simulation. It evaluates whole landscapes of outcomes to draw insights from outcome distributions and outliers. Social network analysis and graph theory are widely used techniques for the evaluation of social systems. Incorporation of these techniques into the data farming process provides analysts examining complex systems with a powerful new suite of tools for more fully exploring and understanding the effect of interactions in complex systems. The integration of network analysis with data farming techniques provides modelers with the capability to gain insight into the effect of network attributes, whether the network is explicitly defined or emergent, on the breadth of the model outcome space and the effect of model inputs on the resultant network statistics. Privacy Breach Analysis in Social Networks Nagle, Frank This chapter addresses various aspects of analyzing privacy breaches in social networks. We first review literature that defines three types of privacy breaches in social networks: interactive, active, and passive. We then survey the various network anonymization schemes that have been constructed to address these privacy breaches. After exploring these breaches and anonymization schemes, we evaluate a measure for determining the level of anonymity inherent in a network graph based on its topological structure. Finally, we close by emphasizing the difficulty of anonymizing social network data while maintaining usability for research purposes and offering areas for future work. Deep Learning Neural Networks and Bayesian Neural Networks in Data Analysis Chernoded Andrey Full Text Available Most of the modern analyses in high energy physics use signal-versus-background classification techniques of machine learning methods and neural networks in particular. Deep learning neural network is the most promising modern technique to separate signal and background and now days can be widely and successfully implemented as a part of physical analysis. In this article we compare Deep learning and Bayesian neural networks application as a classifiers in an instance of top quark analysis. The Analysis of User Behaviour of a Network Management Training Tool using a Neural Network Helen Donelan Full Text Available A novel method for the analysis and interpretation of data that describes the interaction between trainee network managers and a network management training tool is presented. A simulation based approach is currently being used to train network managers, through the use of a simulated network. The motivation is to provide a tool for exposing trainees to a life like situation without disrupting a live network. The data logged by this system describes the detailed interaction between trainee network manager and simulated network. The work presented here provides an analysis of this interaction data that enables an assessment of the capabilities of the trainee network manager as well as an understanding of how the network management tasks are being approached. A neural network architecture is implemented in order to perform an exploratory data analysis of the interaction data. The neural network employs a novel form of continuous self-organisation to discover key features in the data and thus provide new insights into the learning and teaching strategies employed. State of the art applications of social network analysis Can, Fazli; Polat, Faruk Social network analysis increasingly bridges the discovery of patterns in diverse areas of study as more data becomes available and complex. Yet the construction of huge networks from large data often requires entirely different approaches for analysis including; graph theory, statistics, machine learning and data mining. This work covers frontier studies on social network analysis and mining from different perspectives such as social network sites, financial data, e-mails, forums, academic research funds, XML technology, blog content, community detection and clique finding, prediction of user Network analysis and synthesis a modern systems theory approach Anderson, Brian D O Geared toward upper-level undergraduates and graduate students, this book offers a comprehensive look at linear network analysis and synthesis. It explores state-space synthesis as well as analysis, employing modern systems theory to unite the classical concepts of network theory. The authors stress passive networks but include material on active networks. They avoid topology in dealing with analysis problems and discuss computational techniques. The concepts of controllability, observability, and degree are emphasized in reviewing the state-variable description of linear systems. Explorations Statistical Network Analysis for Functional MRI: Mean Networks and Group Comparisons. Cedric E Ginestet Full Text Available Comparing networks in neuroscience is hard, because the topological properties of a given network are necessarily dependent on the number of edges of that network. This problem arises in the analysis of both weighted and unweighted networks. The term density is often used in this context, in order to refer to the mean edge weight of a weighted network, or to the number of edges in an unweighted one. Comparing families of networks is therefore statistically difficult because differences in topology are necessarily associated with differences in density. In this review paper, we consider this problem from two different perspectives, which include (i the construction of summary networks, such as how to compute and visualize the mean network from a sample of network-valued data points; and (ii how to test for topological differences, when two families of networks also exhibit significant differences in density. In the first instance, we show that the issue of summarizing a family of networks can be conducted by either adopting a mass-univariate approach, which produces a statistical parametric network (SPN, or by directly computing the mean network, provided that a metric has been specified on the space of all networks with a given number of nodes. In the second part of this review, we then highlight the inherent problems associated with the comparison of topological functions of families of networks that differ in density. In particular, we show that a wide range of topological summaries, such as global efficiency and network modularity are highly sensitive to differences in density. Moreover, these problems are not restricted to unweighted metrics, as we demonstrate that the same issues remain present when considering the weighted versions of these metrics. We conclude by encouraging caution, when reporting such statistical comparisons, and by emphasizing the importance of constructing summary networks. Centrality measures in temporal networks with time series analysis Huang, Qiangjuan; Zhao, Chengli; Zhang, Xue; Wang, Xiaojie; Yi, Dongyun The study of identifying important nodes in networks has a wide application in different fields. However, the current researches are mostly based on static or aggregated networks. Recently, the increasing attention to networks with time-varying structure promotes the study of node centrality in temporal networks. In this paper, we define a supra-evolution matrix to depict the temporal network structure. With using of the time series analysis, the relationships between different time layers can be learned automatically. Based on the special form of the supra-evolution matrix, the eigenvector centrality calculating problem is turned into the calculation of eigenvectors of several low-dimensional matrices through iteration, which effectively reduces the computational complexity. Experiments are carried out on two real-world temporal networks, Enron email communication network and DBLP co-authorship network, the results of which show that our method is more efficient at discovering the important nodes than the common aggregating method. Reliability Analysis of Wireless Sensor Networks Using Markovian Model Jin Zhu Full Text Available This paper investigates reliability analysis of wireless sensor networks whose topology is switching among possible connections which are governed by a Markovian chain. We give the quantized relations between network topology, data acquisition rate, nodes' calculation ability, and network reliability. By applying Lyapunov method, sufficient conditions of network reliability are proposed for such topology switching networks with constant or varying data acquisition rate. With the conditions satisfied, the quantity of data transported over wireless network node will not exceed node capacity such that reliability is ensured. Our theoretical work helps to provide a deeper understanding of real-world wireless sensor networks, which may find its application in the fields of network design and topology control. Neural Network Analysis of LEAP Energy Spectra Holdridge, Robert E The Laser Electron Acceleration Project (LEAP) group has been conducting a proof of principle experiment on the acceleration of electrons with a pair of crossed laser beams. To date there has been no experimental verification of electron acceleration with crossed laser beams in a dielectric loaded vacuum, although the energy profile of an accelerated electron bunch has been well described by theory. The experiment is subject to unavoidable time dependent fluctuations in the independent variables. Changes in the experimental parameters can dramatically alter the beam profile incident near the focal plane of a high-resolution spectrometer located downstream from the accelerator cell. Neural networks (NNs) appear to provide an ideal tool for the positive determination of an acceleration event, being adaptable and able to handle highly complex nonlinear problems. Typical NNs under such conditions require a training set consisting of a representative data set along with ''answers'' which have been determined to be consistent with the variable state of the experimental parameters. A strategy of pattern recognition with respect to the status of independent variables can be employed to determine the signature characteristics of a laser perturbed electron bunch. Data cuts representing characteristics that were thought to be distinctive to accelerated beam profile images were implemented in the algorithm employed. Statistical analysis of the results of data cuts made on the energy profile images from the experiment is presented, as well as conclusions drawn from the results of this analysis. Finally, a discussion of future directions to be taken in this work is given including the orientation towards on-line, real-time analysis. SOCIOLOGICAL UNDERSTANDING OF INTERNET: THEORETICAL APPROACHES TO THE NETWORK ANALYSIS D. E. Dobrinskaya Full Text Available The network is an efficient way of social structure analysis for contemporary sociologists. It gives broad opportunities for detailed and fruitful research of different patterns of ties and social relations by quantitative analytical methods and visualization of network models. The network metaphor is used as the most representative tool for description of a new type of society. This new type is characterized by flexibility, decentralization and individualization. Network organizational form became the dominant form in modern societies. The network is also used as a mode of inquiry. Actually three theoretical network approaches in the Internet research case are the most relevant: social network analysis, â€œnetwork societyâ€� theory and actor-network theory. Every theoretical approach has got its own notion of network. Their special methodological and theoretical features contribute to the Internet studies in different ways. The article represents a brief overview of these network approaches. This overview demonstrates the absence of a unified semantic space of the notion of â€œnetworkâ€� category. This fact, in turn, points out the need for detailed analysis of these approaches to reveal their theoretical and empirical possibilities in application to the Internet studies.Â Exploratory social network analysis with Pajek. - 2nd ed. de Nooy, W.; Mrvar, A.; Batagelj, V. This is an extensively revised and expanded second edition of the successful textbook on social network analysis integrating theory, applications, and network analysis using Pajek. The main structural concepts and their applications in social research are introduced with exercises. Pajek software Network meta-analysis: an introduction for pharmacists. Xu, Yina; Amiche, Mohamed Amine; Tadrous, Mina Network meta-analysis is a new tool used to summarize and compare studies for multiple interventions, irrespective of whether these interventions have been directly evaluated against each other. Network meta-analysis is quickly becoming the standard in conducting therapeutic reviews and clinical guideline development. However, little guidance is available to help pharmacists review network meta-analysis studies in their practice. Major institutions such as the Cochrane Collaboration, Agency for Healthcare Research and Quality, Canadian Agency for Drugs and Technologies in Health, and National Institute for Health and Care Excellence Decision Support Unit have endorsed utilizing network meta-analysis to establish therapeutic evidence and inform decision making. Our objective is to introduce this novel technique to pharmacy practitioners, and highlight key assumptions behind network meta-analysis studies. Application of OLAM network in X-ray spectral analysis Liu Yinbing; Zhou Rongsheng The author describes a new approach to the automatic radioisotope identification problem based on the use of OLAM network. Different from the traditional methods, the OLAM network takes the spectrum as a whole comparing its shape with the patterns learned during the training period of the network. It is found that the OLAM network, once adequately trained, is quite suitable to identify a given isotope present in a mixture of elements as well as the relative proportions of each identified substance. Preliminary results are good enough to consider OLAM network as powerful and simple tools in the automatic spectrum analysis Analysis of the airport network of India as a complex weighted network Bagler, Ganesh Transportation infrastructure of a country is one of the most important indicators of its economic growth. Here we study the Airport Network of India (ANI) which represents Indiaâ€™s domestic civil aviation infrastructure as a complex network. We find that ANI, a network of domestic airports connected by air links, is a small-world network characterized by a truncated power-law degree distribution and has a signature of hierarchy. We investigate ANI as a weighted network to explore its various properties and compare them with their topological counterparts. The traffic in ANI, as in the World-wide Airport Network (WAN), is found to be accumulated on interconnected groups of airports and is concentrated between large airports. In contrast to WAN, ANI is found to be having disassortative mixing which is offset by the traffic dynamics. The analysis indicates possible mechanism of formation of a national transportation network, which is different from that on a global scale. Network Analysis of Earth's Co-Evolving Geosphere and Biosphere Hazen, R. M.; Eleish, A.; Liu, C.; Morrison, S. M.; Meyer, M.; Consortium, K. D. A fundamental goal of Earth science is the deep understanding of Earth's dynamic, co-evolving geosphere and biosphere through deep time. Network analysis of geo- and bio- `big data' provides an interactive, quantitative, and predictive visualization framework to explore complex and otherwise hidden high-dimension features of diversity, distribution, and change in the evolution of Earth's geochemistry, mineralogy, paleobiology, and biochemistry [1]. Networks also facilitate quantitative comparison of different geological time periods, tectonic settings, and geographical regions, as well as different planets and moons, through network metrics, including density, centralization, diameter, and transitivity.We render networks by employing data related to geographical, paragenetic, environmental, or structural relationships among minerals, fossils, proteins, and microbial taxa. An important recent finding is that the topography of many networks reflects parameters not explicitly incorporated in constructing the network. For example, networks for minerals, fossils, and protein structures reveal embedded qualitative time axes, with additional network geometries possibly related to extinction and/or other punctuation events (see Figure). Other axes related to chemical activities and volatile fugacities, as well as pressure and/or depth of formation, may also emerge from network analysis. These patterns provide new insights into the way planets evolve, especially Earth's co-evolving geosphere and biosphere. 1. Morrison, S.M. et al. (2017) Network analysis of mineralogical systems. American Mineralogist 102, in press. Figure Caption: A network of Phanerozoic Era fossil animals from the past 540 million years includes blue, red, and black circles (nodes) representing family-level taxa and grey lines (links) between coexisting families. Age information was not used in the construction of this network; nevertheless an intrinsic timeline is embedded in the network topology. In Topology design and performance analysis of an integrated communication network Li, V. O. K.; Lam, Y. F.; Hou, T. C.; Yuen, J. H. A research study on the topology design and performance analysis for the Space Station Information System (SSIS) network is conducted. It is begun with a survey of existing research efforts in network topology design. Then a new approach for topology design is presented. It uses an efficient algorithm to generate candidate network designs (consisting of subsets of the set of all network components) in increasing order of their total costs, and checks each design to see if it forms an acceptable network. This technique gives the true cost-optimal network, and is particularly useful when the network has many constraints and not too many components. The algorithm for generating subsets is described in detail, and various aspects of the overall design procedure are discussed. Two more efficient versions of this algorithm (applicable in specific situations) are also given. Next, two important aspects of network performance analysis: network reliability and message delays are discussed. A new model is introduced to study the reliability of a network with dependent failures. For message delays, a collection of formulas from existing research results is given to compute or estimate the delays of messages in a communication network without making the independence assumption. The design algorithm coded in PASCAL is included as an appendix. Applications of social network analysis to obesity: a systematic review. Zhang, S; de la Haye, K; Ji, M; An, R People's health behaviours and outcomes can be profoundly shaped by the social networks they are embedded in. Based on graph theory, social network analysis is a research framework for the study of social interactions and the structure of these interactions among social actors. A literature search was conducted in PubMed and Web of Science for articles published until August 2017 that applied social network analysis to examine obesity and social networks. Eight studies (three cross-sectional and five longitudinal) conducted in the US (nÂ =Â 6) and Australia (nÂ =Â 2) were identified. Seven focused on adolescents' and one on adults' friendship networks. They examined structural features of these networks that were associated with obesity, including degree distribution, popularity, modularity maximization and K-clique percolation. All three cross-sectional studies that used exponential random graph models found individuals with similar body weight status and/or weight-related behaviour were more likely to share a network tie than individuals with dissimilar traits. Three longitudinal studies using stochastic actor-based models found friendship network characteristics influenced change in individuals' body weight status and/or weight-related behaviour over time. Future research should focus on diverse populations and types of social networks and identifying the mechanisms by which social networks influence obesity to inform network-based interventions. Â© 2018 World Obesity Federation. NEXCADE: perturbation analysis for complex networks. Gitanjali Yadav Full Text Available Recent advances in network theory have led to considerable progress in our understanding of complex real world systems and their behavior in response to external threats or fluctuations. Much of this research has been invigorated by demonstration of the 'robust, yet fragile' nature of cellular and large-scale systems transcending biology, sociology, and ecology, through application of the network theory to diverse interactions observed in nature such as plant-pollinator, seed-dispersal agent and host-parasite relationships. In this work, we report the development of NEXCADE, an automated and interactive program for inducing disturbances into complex systems defined by networks, focusing on the changes in global network topology and connectivity as a function of the perturbation. NEXCADE uses a graph theoretical approach to simulate perturbations in a user-defined manner, singly, in clusters, or sequentially. To demonstrate the promise it holds for broader adoption by the research community, we provide pre-simulated examples from diverse real-world networks including eukaryotic protein-protein interaction networks, fungal biochemical networks, a variety of ecological food webs in nature as well as social networks. NEXCADE not only enables network visualization at every step of the targeted attacks, but also allows risk assessment, i.e. identification of nodes critical for the robustness of the system of interest, in order to devise and implement context-based strategies for restructuring a network, or to achieve resilience against link or node failures. Source code and license for the software, designed to work on a Linux-based operating system (OS can be downloaded at http://www.nipgr.res.in/nexcade_download.html. In addition, we have developed NEXCADE as an OS-independent online web server freely available to the scientific community without any login requirement at http://www.nipgr.res.in/nexcade.html. Why social network analysis is important to Air Force applications Havig, Paul R.; McIntire, John P.; Geiselman, Eric; Mohd-Zaid, Fairul Social network analysis is a powerful tool used to help analysts discover relationships amongst groups of people as well as individuals. It is the mathematics behind such social networks as Facebook and MySpace. These networks alone cause a huge amount of data to be generated and the issue is only compounded once one adds in other electronic media such as e-mails and twitter. In this paper we outline the basics of social network analysis and how it may be used in current and future Air Force applications. Weighted Complex Network Analysis of Shanghai Rail Transit System Yingying Xing Full Text Available With increasing passenger flows and construction scale, Shanghai rail transit system (RTS has entered a new era of networking operation. In addition, the structure and properties of the RTS network have great implications for urban traffic planning, design, and management. Thus, it is necessary to acquire their network properties and impacts. In this paper, the Shanghai RTS, as well as passenger flows, will be investigated by using complex network theory. Both the topological and dynamic properties of the RTS network are analyzed and the largest connected cluster is introduced to assess the reliability and robustness of the RTS network. Simulation results show that the distribution of nodes strength exhibits a power-law behavior and Shanghai RTS network shows a strong weighted rich-club effect. This study also indicates that the intentional attacks are more detrimental to the RTS network than to the random weighted network, but the random attacks can cause slightly more damage to the random weighted network than to the RTS network. Our results provide a richer view of complex weighted networks in real world and possibilities of risk analysis and policy decisions for the RTS operation department. Once for All: A Novel Robust System for Co-expression of Multiple Chimeric Fluorescent Fusion Proteins in Plants Guitao Zhong Full Text Available Chimeric fluorescent fusion proteins have been employed as a powerful tool to reveal the subcellular localizations and dynamics of proteins in living cells. Co-expression of a fluorescent fusion protein with well-known organelle markers in the same cell is especially useful in revealing its spatial and temporal functions of the protein in question. However, the conventional methods for co-expressing multiple fluorescent tagged proteins in plants have the drawbacks of low expression efficiency, variations in the expression level and time-consuming genetic crossing. Here, we have developed a novel robust system that allows for high-efficient co-expression of multiple chimeric fluorescent fusion proteins in plants in a time-saving fashion. This system takes advantage of employing a single expression vector which consists of multiple semi-independent expressing cassettes for the protein co-expression thereby overcoming the limitations of using multiple independent expressing plasmids. In addition, it is a highly manipulable DNA assembly system, in which modification and recombination of DNA molecules are easily achieved through an optimized one-step assembly reaction. By employing this effective system, we demonstrated that co-expression of two chimeric fluorescent fusion reporter proteins of vacuolar sorting receptor and secretory carrier membrane protein gave rise to their perspective subcellular localizations in plants via both transient expression and stable transformation. Thus, we believed that this technical advance represents a promising approach for multi-color-protein co-expression in plant cells. Validation of network communicability metrics for the analysis of brain structural networks. Jennifer Andreotti Full Text Available Computational network analysis provides new methods to analyze the brain's structural organization based on diffusion imaging tractography data. Networks are characterized by global and local metrics that have recently given promising insights into diagnosis and the further understanding of psychiatric and neurologic disorders. Most of these metrics are based on the idea that information in a network flows along the shortest paths. In contrast to this notion, communicability is a broader measure of connectivity which assumes that information could flow along all possible paths between two nodes. In our work, the features of network metrics related to communicability were explored for the first time in the healthy structural brain network. In addition, the sensitivity of such metrics was analysed using simulated lesions to specific nodes and network connections. Results showed advantages of communicability over conventional metrics in detecting densely connected nodes as well as subsets of nodes vulnerable to lesions. In addition, communicability centrality was shown to be widely affected by the lesions and the changes were negatively correlated with the distance from lesion site. In summary, our analysis suggests that communicability metrics that may provide an insight into the integrative properties of the structural brain network and that these metrics may be useful for the analysis of brain networks in the presence of lesions. Nevertheless, the interpretation of communicability is not straightforward; hence these metrics should be used as a supplement to the more standard connectivity network metrics. Using Social Network Analysis to Assess Mentorship and Collaboration in a Public Health Network. Petrescu-Prahova, Miruna; Belza, Basia; Leith, Katherine; Allen, Peg; Coe, Norma B; Anderson, Lynda A Addressing chronic disease burden requires the creation of collaborative networks to promote systemic changes and engage stakeholders. Although many such networks exist, they are rarely assessed with tools that account for their complexity. This study examined the structure of mentorship and collaboration relationships among members of the Healthy Aging Research Network (HAN) using social network analysis (SNA). We invited 97 HAN members and partners to complete an online social network survey that included closed-ended questions about HAN-specific mentorship and collaboration during the previous 12 months. Collaboration was measured by examining the activity of the network on 6 types of products: published articles, in-progress manuscripts, grant applications, tools, research projects, and presentations. We computed network-level measures such as density, number of components, and centralization to assess the cohesiveness of the network. Sixty-three respondents completed the survey (response rate, 65%). Responses, which included information about collaboration with nonrespondents, suggested that 74% of HAN members were connected through mentorship ties and that all 97 members were connected through at least one form of collaboration. Mentorship and collaboration ties were present both within and across boundaries of HAN member organizations. SNA of public health collaborative networks provides understanding about the structure of relationships that are formed as a result of participation in network activities. This approach may offer members and funders a way to assess the impact of such networks that goes beyond simply measuring products and participation at the individual level. Co-expression of G2-EPSPS and glyphosate acetyltransferase GAT genes conferring high tolerance to glyphosate in soybean Bingfu eGuo Full Text Available Glyphosate is a widely used non-selective herbicide with broad spectrum of weed control around the world. At present, most of the commercial glyphosate tolerant soybeans utilize glyphosate tolerant gene CP4-EPSPS or glyphosate acetyltransferase gene GAT separately. In this study, both glyphosate tolerant gene G2-EPSPS and glyphosate degraded gene GAT were co-transferred into soybean and transgenic plants showed high tolerance to glyphosate. Molecular analysis including PCR, Sothern blot, qRT-PCR and Western blot revealed that target genes have been integrated into genome and expressed effectively at both mRNA and protein levels. Furthermore, the glyphosate tolerance analysis showed that no typical symptom was observed when compared with a glyphosate tolerant line HJ06-698 derived from GR1 transgenic soybean even at four-fold labeled rate of Roundup. Chlorophyll and shikimic acid content analysis of transgenic plant also revealed that these two indexes were not significantly altered after glyphosate application. These results indicated that co-expression of G2-EPSPS and GAT conferred high tolerance to the herbicide glyphosate in soybean. Therefore, combination of tolerant and degraded genes provides a new strategy for developing glyphosate tolerant transgenic crops. Investigation and analysis of network psychology of college students Zhang Xiaoyan Based on basic situational research and analysis carried out on 638 college students using network,we found that as many as 20 percent of the students are not only largely dependent on internet,but also addicted to it.Further biography characteristics analyses for different individuals on the four dimensions of the network forced addiction,tolerance,and time management and interpersonal relationship and health,show that there are significant differences in grades,gender with different education levels of their parents.Further researches on discrepancy that addicted groups have in network entertainment addiction,network information,cyber porn,network relations and network transactions addictions also illustrate that significant discrepancies exist in gender,net age,different discipline and other factors.Finally we put forward some correlative measures to solve the problems of college students network psychology from individuals,schools,and society levels. Perturbation analysis of complete synchronization in networks of phase oscillators. TÃ¶njes, Ralf; Blasius, Bernd The behavior of weakly coupled self-sustained oscillators can often be well described by phase equations. Here we use the paradigm of Kuramoto phase oscillators which are coupled in a network to calculate first- and second-order corrections to the frequency of the fully synchronized state for nonidentical oscillators. The topology of the underlying coupling network is reflected in the eigenvalues and eigenvectors of the network Laplacian which influence the synchronization frequency in a particular way. They characterize the importance of nodes in a network and the relations between them. Expected values for the synchronization frequency are obtained for oscillators with quenched random frequencies on a class of scale-free random networks and for a ErdÃ¶s-RÃ©nyi random network. We briefly discuss an application of the perturbation theory in the second order to network structural analysis. Road Network Vulnerability Analysis Based on Improved Ant Colony Algorithm Yunpeng Wang Full Text Available We present an improved ant colony algorithm-based approach to assess the vulnerability of a road network and identify the critical infrastructures. This approach improves computational efficiency and allows for its applications in large-scale road networks. This research involves defining the vulnerability conception, modeling the traffic utility index and the vulnerability of the road network, and identifying the critical infrastructures of the road network. We apply the approach to a simple test road network and a real road network to verify the methodology. The results show that vulnerability is directly related to traffic demand and increases significantly when the demand approaches capacity. The proposed approach reduces the computational burden and may be applied in large-scale road network analysis. It can be used as a decision-supporting tool for identifying critical infrastructures in transportation planning and management. Network externalities in telecommunication industry: An analysis of Serbian market TrifunoviÄ‡ Dejan Full Text Available This paper deals with network competition and provides empirical analysis of market concentration, network and call externalities, access pricing, price discrimination and switching costs in Serbian mobile phone telecommunications market. It is shown that network externalities governed the expansion of this market until 2008. Upon entry of VIP incumbents didn't engage in predatory behaviour towards entrant aiming to benefit from locked- in users. The policy of mobile phone number portability reduced on-net prices and substantially increased consumer's surplus. In contrast to some previous research, this policy was pro-competitive in Serbia. We have also determined that users of the network with the largest market share benefit the most from call externalities. Finally, one network does not price discriminate between outgoing and incoming roaming calls, which implies that users of this network have higher level pecuniary externalities in roaming compared to users of price discriminating networks. Incremental Centrality Algorithms for Dynamic Network Analysis literature. Â 7.1.3 Small World Networks In 1998, Watts and Strogatz introduced a model that starts with a regular lattice (ring) of n nodes and...and S. Strogatz , "Collective Dynamics of â€˜Small-Worldâ€™ Networks," Nature, vol. 393, pp. 440-442, 1998. [13] T. Opsahl, "Structure and Evolution of...34On Random Graphs," Publicationes Mathematicae, vol. 6, 1959. [167] D.J. Watts and S.H. Strogatz , "Collective Dynamics of â€˜Small-Worldâ€™ Networks Fractal Analysis of Mobile Social Networks Zheng Wei; Pan Qian; Sun Chen; Deng Yu-Fan; Zhao Xiao-Kang; Kang Zhao Fractal and self similarity of complex networks have attracted much attention in recent years. The fractal dimension is a useful method to describe the fractal property of networks. However, the fractal features of mobile social networks (MSNs) are inadequately investigated. In this work, a box-covering method based on the ratio of excluded mass to closeness centrality is presented to investigate the fractal feature of MSNs. Using this method, we find that some MSNs are fractal at different time intervals. Our simulation results indicate that the proposed method is available for analyzing the fractal property of MSNs. (paper) Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness. Broderick, Gordon; Fletcher, Mary Ann; Gallagher, Michael; Barnes, Zachary; Vernon, Suzanne D; Klimas, Nancy G Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response to a challenge. We demonstrate the practical application of such an approach using an example where blood was collected from 26 GWI, 13 healthy control subjects, and 9 unhealthy controls with chronic fatigue at three points during a graded exercise challenge. A 3-way multivariate projection model based on 12 markers of endocrine and immune function was constructed using a training set of nÂ =Â 10 GWI and nÂ =Â 11 healthy controls. These groups were separated almost completely on the basis of two co-expression patterns. In a separate test set these same features allowed for discrimination of new GWI subjects (nÂ =Â 16) from unhealthy (nÂ =Â 9) and healthy control subjects with a sensitivity of 70% and a specificity of 90%. Autocrine CSF-1 and CSF-1 Receptor Co-expression Promotes Renal Cell Carcinoma Growth Menke, Julia; Kriegsmann, JÃ¶rg; Schimanski, Carl Christoph; Schwartz, Melvin M.; Schwarting, Andreas; Kelley, Vicki R. Renal cell carcinoma is increasing in incidence but the molecular mechanisms regulating its growth remain elusive. Co-expression of the monocytic growth factor CSF-1 and its receptor CSF-1R on renal tubular epithelial cells (TEC) will promote proliferation and anti-apoptosis during regeneration of renal tubules. Here we show that a CSF-1-dependent autocrine pathway is also responsible for the growth of renal cell carcinoma (RCC). CSF-1 and CSF-1R were co-expressed in RCC and TEC proximally adjacent to RCC. CSF-1 engagement of CSF-1R promoted RCC survival and proliferation and reduced apoptosis, in support of the likelihood that CSF-1R effector signals mediate RCC growth. In vivo CSF-1R blockade using a CSF-1R tyrosine kinase inhibitor decreased RCC proliferation and macrophage infiltration in a manner associated with a dramatic reduction in tumor mass. Further mechanistic investigations linked CSF-1 and EGF signaling in RCC. Taken together, our results suggest that budding RCC stimulates the proximal adjacent microenvironment in the kidney to release mediators of CSF-1, CSF-1R and EGF expression in RCC. Further, our findings imply that targeting CSF-1/CSF-1R signaling may be therapeutically effective in RCC. PMID:22052465 NAP: The Network Analysis Profiler, a web tool for easier topological analysis and comparison of medium-scale biological networks. Theodosiou, Theodosios; Efstathiou, Georgios; Papanikolaou, Nikolas; Kyrpides, Nikos C; Bagos, Pantelis G; Iliopoulos, Ioannis; Pavlopoulos, Georgios A Nowadays, due to the technological advances of high-throughput techniques, Systems Biology has seen a tremendous growth of data generation. With network analysis, looking at biological systems at a higher level in order to better understand a system, its topology and the relationships between its components is of a great importance. Gene expression, signal transduction, protein/chemical interactions, biomedical literature co-occurrences, are few of the examples captured in biological network representations where nodes represent certain bioentities and edges represent the connections between them. Today, many tools for network visualization and analysis are available. Nevertheless, most of them are standalone applications that often (i) burden users with computing and calculation time depending on the network's size and (ii) focus on handling, editing and exploring a network interactively. While such functionality is of great importance, limited efforts have been made towards the comparison of the topological analysis of multiple networks. Network Analysis Provider (NAP) is a comprehensive web tool to automate network profiling and intra/inter-network topology comparison. It is designed to bridge the gap between network analysis, statistics, graph theory and partially visualization in a user-friendly way. It is freely available and aims to become a very appealing tool for the broader community. It hosts a great plethora of topological analysis methods such as node and edge rankings. Few of its powerful characteristics are: its ability to enable easy profile comparisons across multiple networks, find their intersection and provide users with simplified, high quality plots of any of the offered topological characteristics against any other within the same network. It is written in R and Shiny, it is based on the igraph library and it is able to handle medium-scale weighted/unweighted, directed/undirected and bipartite graphs. NAP is available at http://bioinformatics.med.uoc.gr/NAP . Bandwidth Analysis of Smart Meter Network Infrastructure Balachandran, Kardi; Olsen, Rasmus LÃ¸venstein; Pedersen, Jens Myrup Advanced Metering Infrastructure (AMI) is a net-work infrastructure in Smart Grid, which links the electricity customers to the utility company. This network enables smart services by making it possible for the utility company to get an overview of their customers power consumption and also control...... devices in their costumers household e.g. heat pumps. With these smart services, utility companies can do load balancing on the grid by shifting load using resources the customers have. The problem investigated in this paper is what bandwidth require-ments can be expected when implementing such network...... to utilize smart meters and which existing broadband network technologies can facilitate this smart meter service. Initially, scenarios for smart meter infrastructure are identified. The paper defines abstraction models which cover the AMI scenarios. When the scenario has been identified a general overview... Stability analysis of impulsive parabolic complex networks Wang Jinliang, E-mail: wangjinliang1984@yahoo.com.cn [Science and Technology on Aircraft Control Laboratory, School of Automation Science and Electrical Engineering, Beihang University, XueYuan Road, No. 37, HaiDian District, Beijing 100191 (China); Wu Huaining [Science and Technology on Aircraft Control Laboratory, School of Automation Science and Electrical Engineering, Beihang University, XueYuan Road, No. 37, HaiDian District, Beijing 100191 (China) Highlights: > Two impulsive parabolic complex network models are proposed. > The global exponential stability of impulsive parabolic complex networks are considered. > The robust global exponential stability of impulsive parabolic complex networks are considered. - Abstract: In the present paper, two kinds of impulsive parabolic complex networks (IPCNs) are considered. In the first one, all nodes have the same time-varying delay. In the second one, different nodes have different time-varying delays. Using the Lyapunov functional method combined with the inequality techniques, some global exponential stability criteria are derived for the IPCNs. Furthermore, several robust global exponential stability conditions are proposed to take uncertainties in the parameters of the IPCNs into account. Finally, numerical simulations are presented to illustrate the effectiveness of the results obtained here. Transcription regulatory networks analysis using CAGE TegnÃ©r, Jesper N. Mapping out cellular networks in general and transcriptional networks in particular has proved to be a bottle-neck hampering our understanding of biological processes. Integrative approaches fusing computational and experimental technologies for decoding transcriptional networks at a high level of resolution is therefore of uttermost importance. Yet, this is challenging since the control of gene expression in eukaryotes is a complex multi-level process influenced by several epigenetic factors and the fine interplay between regulatory proteins and the promoter structure governing the combinatorial regulation of gene expression. In this chapter we review how the CAGE data can be integrated with other measurements such as expression, physical interactions and computational prediction of regulatory motifs, which together can provide a genome-wide picture of eukaryotic transcriptional regulatory networks at a new level of resolution. Â© 2010 by Pan Stanford Publishing Pte. Ltd. All rights reserved. Wang Jinliang; Wu Huaining Highlights: â†’ Two impulsive parabolic complex network models are proposed. â†’ The global exponential stability of impulsive parabolic complex networks are considered. â†’ The robust global exponential stability of impulsive parabolic complex networks are considered. - Abstract: In the present paper, two kinds of impulsive parabolic complex networks (IPCNs) are considered. In the first one, all nodes have the same time-varying delay. In the second one, different nodes have different time-varying delays. Using the Lyapunov functional method combined with the inequality techniques, some global exponential stability criteria are derived for the IPCNs. Furthermore, several robust global exponential stability conditions are proposed to take uncertainties in the parameters of the IPCNs into account. Finally, numerical simulations are presented to illustrate the effectiveness of the results obtained here. Latent Space Approaches to Social Network Analysis Hoff, Peter D; Raftery, Adrian E; Handcock, Mark S .... In studies of social networks, recent emphasis has been placed on random graph models where the nodes usually represent individual social actors and the edges represent the presence of a specified... Social network analysis of sustainable transportation organizations. Studying how organizations communicate with each other can provide important insights into the influence, and policy success of different types of organizations. This study examines the communication networks of 121 organizations promoting sustainabl... Network Analysis in Community Psychology: Looking Back, Looking Forward. Neal, Zachary P; Neal, Jennifer Watling Network analysis holds promise for community psychology given the field's aim to understand the interplay between individuals and their social contexts. Indeed, because network analysis focuses explicitly on patterns of relationships between actors, its theories and methods are inherently extra-individual in nature and particularly well suited to characterizing social contexts. But, to what extent has community psychology taken advantage of this network analysis as a tool for capturing context? To answer these questions, this study provides a review of the use network analysis in articles published in American Journal of Community Psychology. Looking back, we describe and summarize the ways that network analysis has been employed in community psychology research to understand the range of ways community psychologists have found the technique helpful. Looking forward and paying particular attention to analytic issues identified in past applications, we provide some recommendations drawn from the network analysis literature to facilitate future applications of network analysis in community psychology. Â© 2017 The Authors. American Journal of Community Psychology published by Wiley Periodicals, Inc. on behalf of Society for Community Research and Action. Using Social Network Analysis to Investigate Positive EOL Communication. Xu, Jiayun; Yang, Rumei; Wilson, Andrew; Reblin, Maija; Clayton, Margaret F; Ellington, Lee End of life (EOL) communication is a complex process involving the whole family and multiple care providers. Applications of analysis techniques that account for communication beyond the patient and patient/provider, will improve clinical understanding of EOL communication. To introduce the use of social network analysis to EOL communication data, and to provide an example of applying social network analysis to home hospice interactions. We provide a description of social network analysis using social network analysis to model communication patterns during home hospice nursing visits. We describe three social network attributes (i.e. magnitude, directionality, and reciprocity) in the expression of positive emotion among hospice nurses, family caregivers, and hospice cancer patients. Differences in communication structure by primary family caregiver gender and across time were also examined. Magnitude (frequency) in the expression of positive emotion occurred most often between nurses and caregivers or nurses and patients. Female caregivers directed more positive emotion to nurses, and nurses directed more positive emotion to other family caregivers when the primary family caregiver was male. Reciprocity (mutuality) in positive emotion declined towards day of death, but increased on day of actual patient death. There was variation in reciprocity by the type of positive emotion expressed. Our example demonstrates that social network analysis can be used to better understand the process of EOL communication. Social network analysis can be expanded to other areas of EOL research, such as EOL decision-making and health care teamwork. Copyright Â© 2018. Published by Elsevier Inc. Value Systems Alignment Analysis in Collaborative Networked Organizations Management Patricia Macedo; Luis Camarinha-Matos The assessment of value systems alignment can play an important role in the formation and evolution of collaborative networks, contributing to reduce potential risks of collaboration. For this purpose, an assessment tool is proposed as part of a collaborative networks information system, supporting both the formation and evolution of long-term strategic alliances and goal-oriented networks. An implementation approach for value system alignment analysis is described, which is intended to assis... A cyberciege traffic analysis extension for teaching network security Chang, Xuquan Stanley.; Chua, Kim Yong. CyberCIEGE is an interactive game simulating realistic scenarios that teaches the players Information Assurance (IA) concepts. The existing game scenarios only provide a high-level abstraction of the networked environment, e.g., nodes do not have Internet protocol (IP) addresses or belong to proper subnets, and there is no packet-level network simulation. This research explored endowing the game with network level traffic analysis, and implementing a game scenario to take advantage of this ne... Statistical and machine learning approaches for network analysis Explore the multidisciplinary nature of complex networks through machine learning techniques Statistical and Machine Learning Approaches for Network Analysis provides an accessible framework for structurally analyzing graphs by bringing together known and novel approaches on graph classes and graph measures for classification. By providing different approaches based on experimental data, the book uniquely sets itself apart from the current literature by exploring the application of machine learning techniques to various types of complex networks. Comprised of chapters written by internation Analysis and Comparison of Typical Models within Distribution Network Design JÃ¸rgensen, Hans Jacob; Larsen, Allan; Madsen, Oli B.G. This paper investigates the characteristics of typical optimisation models within Distribution Network Design. During the paper fourteen models known from the literature will be thoroughly analysed. Through this analysis a schematic approach to categorisation of distribution network design models...... for educational purposes. Furthermore, the paper can be seen as a practical introduction to network design modelling as well as a being an art manual or recipe when constructing such a model.... Network similarity and statistical analysis of earthquake seismic data Deyasi, Krishanu; Chakraborty, Abhijit; Banerjee, Anirban We study the structural similarity of earthquake networks constructed from seismic catalogs of different geographical regions. A hierarchical clustering of underlying undirected earthquake networks is shown using Jensen-Shannon divergence in graph spectra. The directed nature of links indicates that each earthquake network is strongly connected, which motivates us to study the directed version statistically. Our statistical analysis of each earthquake region identifies the hub regions. We cal... Network analysis of Chinese provincial economies Sun, Xiaoqi; An, Haizhong; Liu, Xiaojia Global economic system is a huge network formed by national subnetworks that contains the provincial networks. As the second largest world economy, China has "too big to fail" impact on the interconnected global economy. Detecting the critical sectors and vital linkages inside Chinese economic network is meaningful for understanding the origin of this Chinese impact. Different from tradition network research at national level, this paper focuses on the provincial networks and inter-provincial network. Using Chinese inter-regional input-output table to construct 30 provincial input-output networks and one inter-provincial input-output network, we identify central sectors and vital linkages, as well as analyze economic structure similarity. Results show that (1) Communication Devices sector in Guangdong and that in Jiangsu, Transportation and Storage sector in Shanghai play critical roles in Chinese economy. (2) Advanced manufactures and services industry occupy the central positions in eastern provincial economies, while Construction sector, Heavy industry, and Wholesale and Retail Trades sector are influential in middle and western provinces. (3) The critical monetary flow paths in Chinese economy are Communication Devices sector to Communication Devices sector in Guangdong, Metals Mining sector to Iron and Steel Smelting sector in Henan, Communication Devices sector to Communication Devices sector in Jiangsu, as well as Petroleum Mining sector in Heilongjiang to Petroleum Processing sector in Liaoning. (4) Collective influence results suggest that Finance sector, Transportation and Storage sector, Production of Electricity and Heat sector, and Rubber and Plastics sector in Hainan are strategic influencers, despite being weakly connected. These sectors and input-output relations are worthy of close attention for monitoring Chinese economy. Stochastic modeling and analysis of telecoms networks Decreusefond, Laurent This book addresses the stochastic modeling of telecommunication networks, introducing the main mathematical tools for that purpose, such as Markov processes, real and spatial point processes and stochastic recursions, and presenting a wide list of results on stability, performances and comparison of systems.The authors propose a comprehensive mathematical construction of the foundations of stochastic network theory: Markov chains, continuous time Markov chains are extensively studied using an original martingale-based approach. A complete presentation of stochastic recursions from an Analysis and Design of Complex Network Environments and J. Lowe, â€œThe myths and facts behind cyber security risks for industrial control systems ,â€� in the Proceedings of the VDE Kongress, VDE Congress...questions about 1) how to model them, 2) the design of experiments necessary to discover their structure (and thus adapt system inputs to optimize the...theoretical work that clarifies fundamental limitations of complex networks with network engineering and systems biology to implement specific designs and Conversation Analysis on Social Networking Sites Belkaroui , Rami; Faiz , Rim; Elkhlifi , Aymen International audience; With the explosion of Web 2.0, people are becoming more communicative through expansion of services and multi-platform applications such as microblogs, forums and social networks which establishes social and collabora-tive backgrounds. These services can be seen as very large information repository containing millions of text messages usually organized into complex networks involving users interacting with each other at specific times. Several works focused only to ret... Towards the integration of social network analysis in an inter-organizational networks perspective Bergenholtz, Carsten; WaldstrÃ¸m, Christian This conceptual paper deals with the issue of studying inter-organizational networks while applying social network analysis (SNA). SNA is a widely recognized technique in network research, particularly within intra-organizational settings, while there seems to be a significant gap in the inter......-organizational setting. Based on a literature review of both SNA as a methodology and/or theory and the field of inter-organizational networks, the aim is to gain an overview in order to provide a clear setting for SNA in inter-organizational research.... Assessing Group Interaction with Social Language Network Analysis Scholand, Andrew J.; Tausczik, Yla R.; Pennebaker, James W. In this paper we discuss a new methodology, social language network analysis (SLNA), that combines tools from social language processing and network analysis to assess socially situated working relationships within a group. Specifically, SLNA aims to identify and characterize the nature of working relationships by processing artifacts generated with computer-mediated communication systems, such as instant message texts or emails. Because social language processing is able to identify psychological, social, and emotional processes that individuals are not able to fully mask, social language network analysis can clarify and highlight complex interdependencies between group members, even when these relationships are latent or unrecognized. Rural Health Networks: How Network Analysis Can Inform Patient Care and Organizational Collaboration in a Rural Breast Cancer Screening Network. Prusaczyk, Beth; Maki, Julia; Luke, Douglas A; Lobb, Rebecca Rural health networks have the potential to improve health care quality and access. Despite this, the use of network analysis to study rural health networks is limited. The purpose of this study was to use network analysis to understand how a network of rural breast cancer care providers deliver services and to demonstrate the value of this methodology in this research area. Leaders at 47 Federally Qualified Health Centers and Rural Health Clinics across 10 adjacent rural counties were asked where they refer patients for mammograms or breast biopsies. These clinics and the 22 referral providers that respondents named comprised the network. The network was analyzed graphically and statistically with exponential random graph modeling. Most (96%, n = 45) of the clinics and referral sites (95%, n = 21) are connected to each other. Two clinics of the same type were 62% less likely to refer patients to the same providers as 2 clinics of different types (OR = 0.38, 95% CI = 0.29-0.50). Clinics in the same county have approximately 8 times higher odds of referring patients to the same providers compared to clinics in different counties (OR = 7.80, CI = 4.57-13.31). This study found that geographic location of resources is an important factor in rural health care providers' referral decisions and demonstrated the usefulness of network analysis for understanding rural health networks. These results can be used to guide delivery of patient care and strengthen the network by building resources that take location into account. Â© 2018 National Rural Health Association. [Social network analysis of interdisciplinary cooperation and networking in early prevention and intervention. A pilot study]. KÃ¼nster, A K; Knorr, C; Fegert, J M; Ziegenhain, U Child protection can only be successfully solved by interdisciplinary cooperation and networking. The individual, heterogeneous, and complex needs of families cannot be met sufficiently by one profession alone. To guarantee efficient interdisciplinary cooperation, there should not be any gaps in the network. In addition, each actor in the network should be placed at an optimal position regarding function, responsibilities, and skills. Actors that serve as allocators, such as pediatricians or youth welfare officers, should be in key player positions within the network. Furthermore, successful child protection is preventive and starts early. Social network analysis is an adequate technique to assess network structures and to plan interventions to improve networking. In addition, it is very useful to evaluate the effectiveness of interventions like round tables. We present data from our pilot project which was part of "Guter Start ins Kinderleben" ("a good start into a child's life"). Exemplary network data from one community show that networking is already quite effective with a satisfactory mean density throughout the network. There is potential for improvement in cooperation, especially at the interface between the child welfare and health systems. SNAPS : semantic network traffic analysis through projection and selection Cappers, B.C.M.; van Wijk, J.J.; Harrison, L.; Prigent, N.; Engle, S.; Best, D.; Goodall, J. Most network traffic analysis applications are designed to discover malicious activity by only relying on high-level flow-based message properties. However, to detect security breaches that are specifically designed to target one network (e.g., Advanced Persistent Threats), deep packet inspection An Analysis of the Structure and Evolution of Networks Hua, Guangying As network research receives more and more attention from both academic researchers and practitioners, network analysis has become a fast growing field attracting many researchers from diverse fields such as physics, computer science, and sociology. This dissertation provides a review of theory and research on different real data sets from theâ€¦ Transient stability analysis of a distribution network with distributed generators Xyngi, I.; Ishchenko, A.; Popov, M.; Sluis, van der L. This letter describes the transient stability analysis of a 10-kV distribution network with wind generators, microturbines, and CHP plants. The network being modeled in Matlab/Simulink takes into account detailed dynamic models of the generators. Fault simulations at various locations are Network analysis reveals multiscale controls on streamwater chemistry Kevin J. McGuire; Christian E. Torgersen; Gene E. Likens; Donald C. Buso; Winsor H. Lowe; Scott W. Bailey By coupling synoptic data from a basin-wide assessment of streamwater chemistry with network-based geostatistical analysis, we show that spatial processes differentially affect biogeochemical condition and pattern across a headwater stream network. We analyzed a high-resolution dataset consisting of 664 water samples collected every 100 m throughout 32 tributaries in... PROJECT ACTIVITY ANALYSIS WITHOUT THE NETWORK MODEL S. Munapo ENGLISH ABSTRACT: This paper presents a new procedure for analysing and managing activity sequences in projects. The new procedure determines critical activities, critical path, start times, free floats, crash limits, and other useful information without the use of the network model. Even though network models have been successfully used in project management so far, there are weaknesses associated with the use. A network is not easy to generate, and dummies that are usually associated with it make the network diagram complex â€“ and dummy activities have no meaning in the original project management problem. The network model for projects can be avoided while still obtaining all the useful information that is required for project management. What are required are the activities, their accurate durations, and their predecessors. AFRIKAANSE OPSOMMING: Die navorsing beskryf â€™n nuwerwetse metode vir die ontleding en bestuur van die sekwensiÃ«le aktiwiteite van projekte. Die voorgestelde metode bepaal kritiese aktiwiteite, die kritieke pad, aanvangstye, speling, verhasing, en ander groothede sonder die gebruik van â€™n netwerkmodel. Die metode funksioneer bevredigend in die praktyk, en omseil die administratiewe rompslomp van die tradisionele netwerkmodelle. Hierarchical analysis of dependency in metabolic networks. Gagneur, Julien; Jackson, David B; Casari, Georg Elucidation of metabolic networks for an increasing number of organisms reveals that even small networks can contain thousands of reactions and chemical species. The intimate connectivity between components complicates their decomposition into biologically meaningful sub-networks. Moreover, traditional higher-order representations of metabolic networks as metabolic pathways, suffers from the lack of rigorous definition, yielding pathways of disparate content and size. We introduce a hierarchical representation that emphasizes the gross organization of metabolic networks in largely independent pathways and sub-systems at several levels of independence. The approach highlights the coupling of different pathways and the shared compounds responsible for those couplings. By assessing our results on Escherichia coli (E.coli metabolic reactions, Genetic Circuits Research Group, University of California, San Diego, http://gcrg.ucsd.edu/organisms/ecoli.html, 'model v 1.01. reactions') against accepted biochemical annotations, we provide the first systematic synopsis of an organism's metabolism. Comparison with operons of E.coli shows that low-level clusters are reflected in genome organization and gene regulation. Source code, data sets and supplementary information are available at http://www.mas.ecp.fr/labo/equipe/gagneur/hierarchy/hierarchy.html SBEToolbox: A Matlab Toolbox for Biological Network Analysis. Konganti, Kranti; Wang, Gang; Yang, Ence; Cai, James J We present SBEToolbox (Systems Biology and Evolution Toolbox), an open-source Matlab toolbox for biological network analysis. It takes a network file as input, calculates a variety of centralities and topological metrics, clusters nodes into modules, and displays the network using different graph layout algorithms. Straightforward implementation and the inclusion of high-level functions allow the functionality to be easily extended or tailored through developing custom plugins. SBEGUI, a menu-driven graphical user interface (GUI) of SBEToolbox, enables easy access to various network and graph algorithms for programmers and non-programmers alike. All source code and sample data are freely available at https://github.com/biocoder/SBEToolbox/releases. Performance Analysis of IIUM Wireless Campus Network Latif, Suhaimi Abd; Masud, Mosharrof H; Anwar, Farhat International Islamic University Malaysia (IIUM) is one of the leading universities in the world in terms of quality of education that has been achieved due to providing numerous facilities including wireless services to every enrolled student. The quality of this wireless service is controlled and monitored by Information Technology Division (ITD), an ISO standardized organization under the university. This paper aims to investigate the constraints of wireless campus network of IIUM. It evaluates the performance of the IIUM wireless campus network in terms of delay, throughput and jitter. QualNet 5.2 simulator tool has employed to measure these performances of IIUM wireless campus network. The observation from the simulation result could be one of the influencing factors in improving wireless services for ITD and further improvement Multilayer Network Analysis of Nuclear Reactions Zhu, Liang; Ma, Yu-Gang; Chen, Qu; Han, Ding-Ding The nuclear reaction network is usually studied via precise calculation of differential equation sets, and much research interest has been focused on the characteristics of nuclides, such as half-life and size limit. In this paper, however, we adopt the methods from both multilayer and reaction networks, and obtain a distinctive view by mapping all the nuclear reactions in JINA REACLIB database into a directed network with 4 layers: neutron, proton, 4He and the remainder. The layer names correspond to reaction types decided by the currency particles consumed. This combined approach reveals that, in the remainder layer, the Î²-stability has high correlation with node degree difference and overlapping coefficient. Moreover, when reaction rates are considered as node strength, we find that, at lower temperatures, nuclide half-life scales reciprocally with its out-strength. The connection between physical properties and topological characteristics may help to explore the boundary of the nuclide chart. Modelling, synthesis and analysis of biorefinery networks Bertran, Maria-Ona for the conversion of biomass into chemicals, fuels and energy, because they have the potential to maximize biomass value while reducing emissions. The design of biorefinery networks is a complex decisionmaking problem that involves the selection of feedstocks, processing technologies, products, geographical...... locations, and operating conditions, among others. Unlike petroleumbased processing networks, biorefineries rely on feedstocks that are nonhomogeneous across geographical areas in terms of their availability, type and properties. For this reason, the performance of biorefinery networks depends...... of reactions to convert available biomassbased feedstocks into desired products, the selection of processing routes and technologies from a large set of alternatives, or the generation of hybrid technologies through process intensification. Systematic process synthesis and design methods have been developed... Analysis of remote synchronization in complex networks Gambuzza, Lucia Valentina; Cardillo, Alessio; Fiasconaro, Alessandro; Fortuna, Luigi; GÃ³mez-GardeÃ±es, Jesus; Frasca, Mattia A novel regime of synchronization, called remote synchronization, where the peripheral nodes form a phase synchronized cluster not including the hub, was recently observed in star motifs [Bergner et al., Phys. Rev. E 85, 026208 (2012)]. We show the existence of a more general dynamical state of remote synchronization in arbitrary networks of coupled oscillators. This state is characterized by the synchronization of pairs of nodes that are not directly connected via a physical link or any sequence of synchronized nodes. This phenomenon is almost negligible in networks of phase oscillators as its underlying mechanism is the modulation of the amplitude of those intermediary nodes between the remotely synchronized units. Our findings thus show the ubiquity and robustness of these states and bridge the gap from their recent observation in simple toy graphs to complex networks. Integration of heterogeneous molecular networks to unravel gene-regulation in Mycobacterium tuberculosis Dam, van J.C.J.; Schaap, P.J.; Martins dos Santos, V.A.P.; Suarez Diez, M. Background: Different methods have been developed to infer regulatory networks from heterogeneous omics datasets and to construct co-expression networks. Each algorithm produces different networks and efforts have been devoted to automatically integrate them into consensus sets. However each A reliability analysis tool for SpaceWire network Zhou, Qiang; Zhu, Longjiang; Fei, Haidong; Wang, Xingyou A SpaceWire is a standard for on-board satellite networks as the basis for future data-handling architectures. It is becoming more and more popular in space applications due to its technical advantages, including reliability, low power and fault protection, etc. High reliability is the vital issue for spacecraft. Therefore, it is very important to analyze and improve the reliability performance of the SpaceWire network. This paper deals with the problem of reliability modeling and analysis with SpaceWire network. According to the function division of distributed network, a reliability analysis method based on a task is proposed, the reliability analysis of every task can lead to the system reliability matrix, the reliability result of the network system can be deduced by integrating these entire reliability indexes in the matrix. With the method, we develop a reliability analysis tool for SpaceWire Network based on VC, where the computation schemes for reliability matrix and the multi-path-task reliability are also implemented. By using this tool, we analyze several cases on typical architectures. And the analytic results indicate that redundancy architecture has better reliability performance than basic one. In practical, the dual redundancy scheme has been adopted for some key unit, to improve the reliability index of the system or task. Finally, this reliability analysis tool will has a directive influence on both task division and topology selection in the phase of SpaceWire network system design. Integration of heterogeneous molecular networks to unravel gene-regulation in Mycobacterium tuberculosis. van Dam, Jesse C J; Schaap, Peter J; Martins dos Santos, Vitor A P; SuÃ¡rez-Diez, MarÃa Different methods have been developed to infer regulatory networks from heterogeneous omics datasets and to construct co-expression networks. Each algorithm produces different networks and efforts have been devoted to automatically integrate them into consensus sets. However each separate set has an intrinsic value that is diluted and partly lost when building a consensus network. Here we present a methodology to generate co-expression networks and, instead of a consensus network, we propose an integration framework where the different networks are kept and analysed with additional tools to efficiently combine the information extracted from each network. We developed a workflow to efficiently analyse information generated by different inference and prediction methods. Our methodology relies on providing the user the means to simultaneously visualise and analyse the coexisting networks generated by different algorithms, heterogeneous datasets, and a suite of analysis tools. As a show case, we have analysed the gene co-expression networks of Mycobacterium tuberculosis generated using over 600 expression experiments. Regarding DNA damage repair, we identified SigC as a key control element, 12 new targets for LexA, an updated LexA binding motif, and a potential mismatch repair system. We expanded the DevR regulon with 27 genes while identifying 9 targets wrongly assigned to this regulon. We discovered 10 new genes linked to zinc uptake and a new regulatory mechanism for ZuR. The use of co-expression networks to perform system level analysis allows the development of custom made methodologies. As show cases we implemented a pipeline to integrate ChIP-seq data and another method to uncover multiple regulatory layers. Our workflow is based on representing the multiple types of information as network representations and presenting these networks in a synchronous framework that allows their simultaneous visualization while keeping specific associations from the different Muscle networks: Connectivity analysis of EMG activity during postural control Boonstra, Tjeerd W.; Danna-Dos-Santos, Alessander; Xie, Hong-Bo; Roerdink, Melvyn; Stins, John F.; Breakspear, Michael Understanding the mechanisms that reduce the many degrees of freedom in the musculoskeletal system remains an outstanding challenge. Muscle synergies reduce the dimensionality and hence simplify the control problem. How this is achieved is not yet known. Here we use network theory to assess the coordination between multiple muscles and to elucidate the neural implementation of muscle synergies. We performed connectivity analysis of surface EMG from ten leg muscles to extract the muscle networks while human participants were standing upright in four different conditions. We observed widespread connectivity between muscles at multiple distinct frequency bands. The network topology differed significantly between frequencies and between conditions. These findings demonstrate how muscle networks can be used to investigate the neural circuitry of motor coordination. The presence of disparate muscle networks across frequencies suggests that the neuromuscular system is organized into a multiplex network allowing for parallel and hierarchical control structures. Throughput Analysis of Large Wireless Networks with Regular Topologies Hong Kezhu Full Text Available The throughput of large wireless networks with regular topologies is analyzed under two medium-access control schemes: synchronous array method (SAM and slotted ALOHA. The regular topologies considered are square, hexagon, and triangle. Both nonfading channels and Rayleigh fading channels are examined. Furthermore, both omnidirectional antennas and directional antennas are considered. Our analysis shows that the SAM leads to a much higher network throughput than the slotted ALOHA. The network throughput in this paper is measured in either bits-hops per second per Hertz per node or bits-meters per second per Hertz per node. The exact connection between the two measures is shown for each topology. With these two fundamental units, the network throughput shown in this paper can serve as a reliable benchmark for future works on network throughput of large networks. Kezhu Hong An Approach to Data Analysis in 5G Networks Lorena Isabel Barona LÃ³pez Full Text Available 5G networks expect to provide significant advances in network management compared to traditional mobile infrastructures by leveraging intelligence capabilities such as data analysis, prediction, pattern recognition and artificial intelligence. The key idea behind these actions is to facilitate the decision-making process in order to solve or mitigate common network problems in a dynamic and proactive way. In this context, this paper presents the design of Self-Organized Network Management in Virtualized and Software Defined Networks (SELFNET Analyzer Module, which main objective is to identify suspicious or unexpected situations based on metrics provided by different network components and sensors. The SELFNET Analyzer Module provides a modular architecture driven by use cases where analytic functions can be easily extended. This paper also proposes the data specification to define the data inputs to be taking into account in diagnosis process. This data specification has been implemented with different use cases within SELFNET Project, proving its effectiveness. Analysis of Privacy on Social Networks Tomandl, LuboÅ¡ This thesis deals with aÂ question of privacy in aÂ context of social networks. The main substance of these services is the users' option to share an information about their lives. This alone can be aÂ problem for privacy. In the first part of this thesis concentrates on the meaning of privacy as well as its value for both individuals and the society. In the next part the privacy threats on social networks, namely Facebook, are discussed. These threats are disclosed on four levels according to f... Alpha spectral analysis via artificial neural networks Kangas, L.J.; Hashem, S.; Keller, P.E.; Kouzes, R.T.; Troyer, G.L. An artificial neural network system that assigns quality factors to alpha particle energy spectra is discussed. The alpha energy spectra are used to detect plutonium contamination in the work environment. The quality factors represent the levels of spectral degradation caused by miscalibration and foreign matter affecting the instruments. A set of spectra was labeled with a quality factor by an expert and used in training the artificial neural network expert system. The investigation shows that the expert knowledge of alpha spectra quality factors can be transferred to an ANN system Network graph analysis and visualization with Gephi Cherven, Ken A practical, hands-on guide, that provides you with all the tools you need to visualize and analyze your data using network graphs with Gephi.This book is for data analysts who want to intuitively reveal patterns and trends, highlight outliers, and tell stories with their data using Gephi. It is great for anyone looking to explore interactions within network datasets, whether the data comes from social media or elsewhere. It is also a valuable resource for those seeking to learn more about Gephi without being overwhelmed by technical details. Geometrical methods for power network analysis Bellucci, Stefano; Tiwari, Bhupendra Nath [Istituto Nazioneale di Fisica Nucleare, Frascati, Rome (Italy). Lab. Nazionali di Frascati; Gupta, Neeraj [Indian Institute of Technology, Kanpur (India). Dept. of Electrical Engineering Uses advanced geometrical methods to analyse power networks. Provides a self-contained and tutorial introduction. Includes a fully worked-out example for the IEEE 5 bus system. This book is a short introduction to power system planning and operation using advanced geometrical methods. The approach is based on well-known insights and techniques developed in theoretical physics in the context of Riemannian manifolds. The proof of principle and robustness of this approach is examined in the context of the IEEE 5 bus system. This work addresses applied mathematicians, theoretical physicists and power engineers interested in novel mathematical approaches to power network theory. Satellite communications network design and analysis Jo, Kenneth Y This authoritative book provides a thorough understanding of the fundamental concepts of satellite communications (SATCOM) network design and performance assessments. You find discussions on a wide class of SATCOM networks using satellites as core components, as well as coverage key applications in the field. This in-depth resource presents a broad range of critical topics, from geosynchronous Earth orbiting (GEO) satellites and direct broadcast satellite systems, to low Earth orbiting (LEO) satellites, radio standards and protocols.This invaluable reference explains the many specific uses of Social network analysis of public health programs to measure partnership. Schoen, Martin W; Moreland-Russell, Sarah; Prewitt, Kim; Carothers, Bobbi J In order to prevent chronic diseases, community-based programs are encouraged to take an ecological approach to public health promotion and involve many diverse partners. Little is known about measuring partnership in implementing public health strategies. We collected data from 23 Missouri communities in early 2012 that received funding from three separate programs to prevent obesity and/or reduce tobacco use. While all of these funding programs encourage partnership, only the Social Innovation for Missouri (SIM) program included a focus on building community capacity and enhancing collaboration. Social network analysis techniques were used to understand contact and collaboration networks in community organizations. Measurements of average degree, density, degree centralization, and betweenness centralization were calculated for each network. Because of the various sizes of the networks, we conducted comparative analyses with and without adjustment for network size. SIM programs had increased measurements of average degree for partner collaboration and larger networks. When controlling for network size, SIM groups had higher measures of network density and lower measures of degree centralization and betweenness centralization. SIM collaboration networks were more dense and less centralized, indicating increased partnership. The methods described in this paper can be used to compare partnership in community networks of various sizes. Further research is necessary to define causal mechanisms of partnership development and their relationship to public health outcomes. Copyright Â© 2014 Elsevier Ltd. All rights reserved. Error performance analysis in downlink cellular networks with interference management Afify, Laila H. Modeling aggregate network interference in cellular networks has recently gained immense attention both in academia and industry. While stochastic geometry based models have succeeded to account for the cellular network geometry, they mostly abstract many important wireless communication system aspects (e.g., modulation techniques, signal recovery techniques). Recently, a novel stochastic geometry model, based on the Equivalent-in-Distribution (EiD) approach, succeeded to capture the aforementioned communication system aspects and extend the analysis to averaged error performance, however, on the expense of increasing the modeling complexity. Inspired by the EiD approach, the analysis developed in [1] takes into consideration the key system parameters, while providing a simple tractable analysis. In this paper, we extend this framework to study the effect of different interference management techniques in downlink cellular network. The accuracy of the proposed analysis is verified via Monte Carlo simulations. Combining morphological analysis and Bayesian Networks for strategic decision support CSIR Research Space (South Africa) De Waal, AJ Full Text Available Morphological analysis (MA) and Bayesian networks (BN) are two closely related modelling methods, each of which has its advantages and disadvantages for strategic decision support modelling. MA is a method for defining, linking and evaluating... C2 Network Analysis: Insights into Coordination & Understanding Hansberger, Jeffrey T; Schreiber, Craig; Spain, Randall D ...) workload management. This paper will address recent efforts, tools, and approaches on measuring and analyzing two of these distributed cognitive attributes through network analysis, coordination across agents and mental models... Enabling dynamic network analysis through visualization in TVNViewer Curtis Ross E Full Text Available Abstract Background Many biological processes are context-dependent or temporally specific. As a result, relationships between molecular constituents evolve across time and environments. While cutting-edge machine learning techniques can recover these networks, exploring and interpreting the rewiring behavior is challenging. Information visualization shines in this type of exploratory analysis, motivating the development ofTVNViewer (http://sailing.cs.cmu.edu/tvnviewer, a visualization tool for dynamic network analysis. Results In this paper, we demonstrate visualization techniques for dynamic network analysis by using TVNViewer to analyze yeast cell cycle and breast cancer progression datasets. Conclusions TVNViewer is a powerful new visualization tool for the analysis of biological networks that change across time or space. Background Many biological processes are context-dependent or temporally specific. As a result, relationships between molecular constituents evolve across time and environments. While cutting-edge machine learning techniques can recover these networks, exploring and interpreting the rewiring behavior is challenging. Information visualization shines in this type of exploratory analysis, motivating the development ofTVNViewer (http://sailing.cs.cmu.edu/tvnviewer), a visualization tool for dynamic network analysis. Results In this paper, we demonstrate visualization techniques for dynamic network analysis by using TVNViewer to analyze yeast cell cycle and breast cancer progression datasets. Conclusions TVNViewer is a powerful new visualization tool for the analysis of biological networks that change across time or space. PMID:22897913 Flory-Stockmayer analysis on reprocessable polymer networks Li, Lingqiao; Chen, Xi; Jin, Kailong; Torkelson, John Reprocessable polymer networks can undergo structure rearrangement through dynamic chemistries under proper conditions, making them a promising candidate for recyclable crosslinked materials, e.g. tires. This research field has been focusing on various chemistries. However, there has been lacking of an essential physical theory explaining the relationship between abundancy of dynamic linkages and reprocessability. Based on the classical Flory-Stockmayer analysis on network gelation, we developed a similar analysis on reprocessable polymer networks to quantitatively predict the critical condition for reprocessability. Our theory indicates that it is unnecessary for all bonds to be dynamic to make the resulting network reprocessable. As long as there is no percolated permanent network in the system, the material can fully rearrange. To experimentally validate our theory, we used a thiol-epoxy network model system with various dynamic linkage compositions. The stress relaxation behavior of resulting materials supports our theoretical prediction: only 50 % of linkages between crosslinks need to be dynamic for a tri-arm network to be reprocessable. Therefore, this analysis provides the first fundamental theoretical platform for designing and evaluating reprocessable polymer networks. We thank McCormick Research Catalyst Award Fund and ISEN cluster fellowship (L. L.) for funding support. Analysis of Network Topologies Underlying Ethylene Growth Response Kinetics. Prescott, Aaron M; McCollough, Forest W; Eldreth, Bryan L; Binder, Brad M; Abel, Steven M Most models for ethylene signaling involve a linear pathway. However, measurements of seedling growth kinetics when ethylene is applied and removed have resulted in more complex network models that include coherent feedforward, negative feedback, and positive feedback motifs. The dynamical responses of the proposed networks have not been explored in a quantitative manner. Here, we explore (i) whether any of the proposed models are capable of producing growth-response behaviors consistent with experimental observations and (ii) what mechanistic roles various parts of the network topologies play in ethylene signaling. To address this, we used computational methods to explore two general network topologies: The first contains a coherent feedforward loop that inhibits growth and a negative feedback from growth onto itself (CFF/NFB). In the second, ethylene promotes the cleavage of EIN2, with the product of the cleavage inhibiting growth and promoting the production of EIN2 through a positive feedback loop (PFB). Since few network parameters for ethylene signaling are known in detail, we used an evolutionary algorithm to explore sets of parameters that produce behaviors similar to experimental growth response kinetics of both wildtype and mutant seedlings. We generated a library of parameter sets by independently running the evolutionary algorithm many times. Both network topologies produce behavior consistent with experimental observations, and analysis of the parameter sets allows us to identify important network interactions and parameter constraints. We additionally screened these parameter sets for growth recovery in the presence of sub-saturating ethylene doses, which is an experimentally-observed property that emerges in some of the evolved parameter sets. Finally, we probed simplified networks maintaining key features of the CFF/NFB and PFB topologies. From this, we verified observations drawn from the larger networks about mechanisms underlying ethylene Analysis of Network Topologies Underlying Ethylene Growth Response Kinetics Aaron M. Prescott Full Text Available Most models for ethylene signaling involve a linear pathway. However, measurements of seedling growth kinetics when ethylene is applied and removed have resulted in more complex network models that include coherent feedforward, negative feedback, and positive feedback motifs. However, the dynamical responses of the proposed networks have not been explored in a quantitative manner. Here, we explore (i whether any of the proposed models are capable of producing growth-response behaviors consistent with experimental observations and (ii what mechanistic roles various parts of the network topologies play in ethylene signaling. To address this, we used computational methods to explore two general network topologies: The first contains a coherent feedforward loop that inhibits growth and a negative feedback from growth onto itself (CFF/NFB. In the second, ethylene promotes the cleavage of EIN2, with the product of the cleavage inhibiting growth and promoting the production of EIN2 through a positive feedback loop (PFB. Since few network parameters for ethylene signaling are known in detail, we used an evolutionary algorithm to explore sets of parameters that produce behaviors similar to experimental growth response kinetics of both wildtype and mutant seedlings. We generated a library of parameter sets by independently running the evolutionary algorithm many times. Both network topologies produce behavior consistent with experimental observations and analysis of the parameter sets allows us to identify important network interactions and parameter constraints. We additionally screened these parameter sets for growth recovery in the presence of sub-saturating ethylene doses, which is an experimentally-observed property that emerges in some of the evolved parameter sets. Finally, we probed simplified networks maintaining key features of the CFF/NFB and PFB topologies. From this, we verified observations drawn from the larger networks about mechanisms Hydroxylation of recombinant human collagen type I alpha 1 in transgenic maize co-expressed with a recombinant human prolyl 4-hydroxylase Pappu Kameshwari M Full Text Available Abstract Background Collagens require the hydroxylation of proline (Pro residues in their triple-helical domain repeating sequence Xaa-Pro-Gly to function properly as a main structural component of the extracellular matrix in animals at physiologically relevant conditions. The regioselective proline hydroxylation is catalyzed by a specific prolyl 4-hydroxylase (P4H as a posttranslational processing step. Results A recombinant human collagen type I Î±-1 (rCIÎ±1 with high percentage of hydroxylated prolines (Hyp was produced in transgenic maize seeds when co-expressed with both the Î±- and Î²- subunits of a recombinant human P4H (rP4H. Germ-specific expression of rCIÎ±1 using maize globulin-1 gene promoter resulted in an average yield of 12 mg/kg seed for the full-length rCIÎ±1 in seeds without co-expression of rP4H and 4 mg/kg seed for the rCIÎ±1 (rCIÎ±1-OH in seeds with co-expression of rP4H. High-resolution mass spectrometry (HRMS analysis revealed that nearly half of the collagenous repeating triplets in rCIÎ±1 isolated from rP4H co-expressing maize line had the Pro residues changed to Hyp residues. The HRMS analysis determined the Hyp content of maize-derived rCIÎ±1-OH as 18.11%, which is comparable to the Hyp level of yeast-derived rCIÎ±1-OH (17.47% and the native human CIa1 (14.59%, respectively. The increased Hyp percentage was correlated with a markedly enhanced thermal stability of maize-derived rCIÎ±1-OH when compared to the non-hydroxylated rCIÎ±1. Conclusions This work shows that maize has potential to produce adequately modified exogenous proteins with mammalian-like post-translational modifications that may be require for their use as pharmaceutical and industrial products. Patricia Macedo Full Text Available The assessment of value systems alignment can play an important role in the formation and evolution of collaborative networks, contributing to reduce potential risks of collaboration. For this purpose, an assessment tool is proposed as part of a collaborative networks information system, supporting both the formation and evolution of long-term strategic alliances and goal-oriented networks. An implementation approach for value system alignment analysis is described, which is intended to assist managers in virtual and networked organizations management. The implementation of the assessment and analysis methods is supported by a set of software services integrated in the information system that supports the management of the networked organizations. A case study in the solar energy sector was conducted, and the data collected through this study allow us to confirm the practical applicability of the proposed methods and the software services. Static analysis of topology-dependent broadcast networks Nanz, Sebastian; Nielson, Flemming; Nielson, Hanne Riis changing network topology is a crucial ingredient. In this paper, we develop a static analysis that automatically constructs an abstract transition system, labelled by actions and connectivity information, to yield a mobility-preserving finite abstraction of the behaviour of a network expressed......Broadcast semantics poses significant challenges over point-to-point communication when it comes to formal modelling and analysis. Current approaches to analysing broadcast networks have focused on fixed connectivities, but this is unsuitable in the case of wireless networks where the dynamically...... in a process calculus with asynchronous local broadcast. Furthermore, we use model checking based on a 3-valued temporal logic to distinguish network behaviour which differs under changing connectivity patterns. (C) 2009 Elsevier Inc. All rights reserved.... Layered signaling regulatory networks analysis of gene expression involved in malignant tumorigenesis of non-resolving ulcerative colitis via integration of cross-study microarray profiles. Fan, Shengjun; Pan, Zhenyu; Geng, Qiang; Li, Xin; Wang, Yefan; An, Yu; Xu, Yan; Tie, Lu; Pan, Yan; Li, Xuejun Ulcerative colitis (UC) was the most frequently diagnosed inflammatory bowel disease (IBD) and closely linked to colorectal carcinogenesis. By far, the underlying mechanisms associated with the disease are still unclear. With the increasing accumulation of microarray gene expression profiles, it is profitable to gain a systematic perspective based on gene regulatory networks to better elucidate the roles of genes associated with disorders. However, a major challenge for microarray data analysis is the integration of multiple-studies generated by different groups. In this study, firstly, we modeled a signaling regulatory network associated with colorectal cancer (CRC) initiation via integration of cross-study microarray expression data sets using Empirical Bayes (EB) algorithm. Secondly, a manually curated human cancer signaling map was established via comprehensive retrieval of the publicly available repositories. Finally, the co-differently-expressed genes were manually curated to portray the layered signaling regulatory networks. Overall, the remodeled signaling regulatory networks were separated into four major layers including extracellular, membrane, cytoplasm and nucleus, which led to the identification of five core biological processes and four signaling pathways associated with colorectal carcinogenesis. As a result, our biological interpretation highlighted the importance of EGF/EGFR signaling pathway, EPO signaling pathway, T cell signal transduction and members of the BCR signaling pathway, which were responsible for the malignant transition of CRC from the benign UC to the aggressive one. The present study illustrated a standardized normalization approach for cross-study microarray expression data sets. Our model for signaling networks construction was based on the experimentally-supported interaction and microarray co-expression modeling. Pathway-based signaling regulatory networks analysis sketched a directive insight into colorectal carcinogenesis Trojan detection model based on network behavior analysis Liu Junrong; Liu Baoxu; Wang Wenjin Based on the analysis of existing Trojan detection technology, this paper presents a Trojan detection model based on network behavior analysis. First of all, we abstract description of the Trojan network behavior, then according to certain rules to establish the characteristic behavior library, and then use the support vector machine algorithm to determine whether a Trojan invasion. Finally, through the intrusion detection experiments, shows that this model can effectively detect Trojans. (authors) Network Analysis of Urban Traffic with Big Bus Data Zhao, Kai Urban traffic analysis is crucial for traffic forecasting systems, urban planning and, more recently, various mobile and network applications. In this paper, we analyse urban traffic with network and statistical methods. Our analysis is based on one big bus dataset containing 45 million bus arrival samples in Helsinki. We mainly address following questions: 1. How can we identify the areas that cause most of the traffic in the city? 2. Why there is a urban traffic? Is bus traffic a key cause ... various classification modes (decision trees, rulesets, boosting, softening thresholds) regarding the classification accuracy and the time required to create the classifier. We showed how to use our VBS tool to obtain per-flow, per-application, and per-content statistics of traffic in computer networks... Computer program for compressible flow network analysis Wilton, M. E.; Murtaugh, J. P. Program solves problem of an arbitrarily connected one dimensional compressible flow network with pumping in the channels and momentum balancing at flow junctions. Program includes pressure drop calculations for impingement flow and flow through pin fin arrangements, as currently found in many air cooled turbine bucket and vane cooling configurations. Network Analysis with the Enron Email Corpus Hardin, J. S.; Sarkis, G.; URC, P. . We use the Enron email corpus to study relationships in a network by applying six different measures of centrality. Our results came out of an in-semester undergraduate research seminar. The Enron corpus is well suited to statistical analyses at all levels of undergraduate education. Through this article's focus on centrality, students can exploreâ€¦ Using Citation Network Analysis in Educational Technology Cho, Yonjoo; Park, Sunyoung Previous reviews in the field of Educational Technology (ET) have revealed some publication patterns according to authors, institutions, and affiliations. However, those previous reviews focused only on the rankings of individual authors and institutions, and did not provide qualitative details on relations and networks of scholars and scholarlyâ€¦ Analysis and Design of Complex Networks systems. 08-NOV-10, . : , Barlas Oguz, Venkat Anantharam. Long range dependent Markov chains with applications , Information Theory and Applications ...JUL-12, . : , Michael Krishnan, Ehsan Haghani, Avideh Zakhor. Packet Length Adaptation in WLANs with Hidden Nodes and Time-Varying Channels, IEEE... WLAN networks with multi-antenna beam-forming nodes. VII. Use of busy/idle signals for discovering optimum AP association VIII Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein. Gargett, Tessa; Grubor-Bauk, Branka; Miller, Darren; Garrod, Tamsin; Yu, Stanley; Wesselingh, Steve; Suhrbier, Andreas; Gowans, Eric J The potential of DNA vaccines has not been realised due to suboptimal delivery, poor antigen expression and the lack of localised inflammation, essential for antigen presentation and an effective immune response to the immunogen. Initially, we examined the delivery of a DNA vaccine encoding a model antigen, luciferase (LUC), to the respiratory tract of mice by encapsulation in a virosome. Virosomes that incorporated influenza virus haemagglutinin effectively delivered DNA to cells in the mouse respiratory tract and resulted in antigen expression and systemic and mucosal immune responses to the immunogen after an intranasal (IN) prime/intradermal (ID) boost regimen, whereas a multidose ID regimen only generated systemic immunity. We also examined systemic immune responses to LUC after ID vaccination with a DNA vaccine, which also encoded one of the several cytolytic or toxic proteins. Although the herpes simplex virus thymidine kinase, in the presence of the prodrug, ganciclovir, resulted in cell death, this failed to increase the humoral or cell-mediated immune responses. In contrast, the co-expression of LUC with the rotavirus non-structural protein 4 (NSP4) protein or a mutant form of mouse perforin, proteins which are directly cytolytic, resulted in increased LUC-specific humoral and cell-mediated immunity. On the other hand, co-expression of LUC with diphtheria toxin subunit A or overexpression of perforin or NSP4 resulted in a lower level of immunity. In summary, the efficacy of DNA vaccines can be improved by targeted IN delivery of DNA or by the induction of cell death in vaccine-targeted cells after ID delivery. Functional Interaction Network Construction and Analysis for Disease Discovery. Wu, Guanming; Haw, Robin Network-based approaches project seemingly unrelated genes or proteins onto a large-scale network context, therefore providing a holistic visualization and analysis platform for genomic data generated from high-throughput experiments, reducing the dimensionality of data via using network modules and increasing the statistic analysis power. Based on the Reactome database, the most popular and comprehensive open-source biological pathway knowledgebase, we have developed a highly reliable protein functional interaction network covering around 60 % of total human genes and an app called ReactomeFIViz for Cytoscape, the most popular biological network visualization and analysis platform. In this chapter, we describe the detailed procedures on how this functional interaction network is constructed by integrating multiple external data sources, extracting functional interactions from human curated pathway databases, building a machine learning classifier called a NaÃ¯ve Bayesian Classifier, predicting interactions based on the trained NaÃ¯ve Bayesian Classifier, and finally constructing the functional interaction database. We also provide an example on how to use ReactomeFIViz for performing network-based data analysis for a list of genes. Network-assisted crop systems genetics: network inference and integrative analysis. Lee, Tak; Kim, Hyojin; Lee, Insuk Although next-generation sequencing (NGS) technology has enabled the decoding of many crop species genomes, most of the underlying genetic components for economically important crop traits remain to be determined. Network approaches have proven useful for the study of the reference plant, Arabidopsis thaliana, and the success of network-based crop genetics will also require the availability of a genome-scale functional networks for crop species. In this review, we discuss how to construct functional networks and elucidate the holistic view of a crop system. The crop gene network then can be used for gene prioritization and the analysis of resequencing-based genome-wide association study (GWAS) data, the amount of which will rapidly grow in the field of crop science in the coming years. Copyright Â© 2015 Elsevier Ltd. All rights reserved. Detecting Distributed Network Traffic Anomaly with Network-Wide Correlation Analysis Yang Dan Full Text Available Distributed network traffic anomaly refers to a traffic abnormal behavior involving many links of a network and caused by the same source (e.g., DDoS attack, worm propagation. The anomaly transiting in a single link might be unnoticeable and hard to detect, while the anomalous aggregation from many links can be prevailing, and does more harm to the networks. Aiming at the similar features of distributed traffic anomaly on many links, this paper proposes a network-wide detection method by performing anomalous correlation analysis of traffic signals' instantaneous parameters. In our method, traffic signals' instantaneous parameters are firstly computed, and their network-wide anomalous space is then extracted via traffic prediction. Finally, an anomaly is detected by a global correlation coefficient of anomalous space. Our evaluation using Abilene traffic traces demonstrates the excellent performance of this approach for distributed traffic anomaly detection. Reliability analysis of cluster-based ad-hoc networks Cook, Jason L.; Ramirez-Marquez, Jose Emmanuel The mobile ad-hoc wireless network (MAWN) is a new and emerging network scheme that is being employed in a variety of applications. The MAWN varies from traditional networks because it is a self-forming and dynamic network. The MAWN is free of infrastructure and, as such, only the mobile nodes comprise the network. Pairs of nodes communicate either directly or through other nodes. To do so, each node acts, in turn, as a source, destination, and relay of messages. The virtue of a MAWN is the flexibility this provides; however, the challenge for reliability analyses is also brought about by this unique feature. The variability and volatility of the MAWN configuration makes typical reliability methods (e.g. reliability block diagram) inappropriate because no single structure or configuration represents all manifestations of a MAWN. For this reason, new methods are being developed to analyze the reliability of this new networking technology. New published methods adapt to this feature by treating the configuration probabilistically or by inclusion of embedded mobility models. This paper joins both methods together and expands upon these works by modifying the problem formulation to address the reliability analysis of a cluster-based MAWN. The cluster-based MAWN is deployed in applications with constraints on networking resources such as bandwidth and energy. This paper presents the problem's formulation, a discussion of applicable reliability metrics for the MAWN, and illustration of a Monte Carlo simulation method through the analysis of several example networks Optimization of deformation monitoring networks using finite element strain analysis Alizadeh-Khameneh, M. Amin; Eshagh, Mehdi; Jensen, Anna B. O. An optimal design of a geodetic network can fulfill the requested precision and reliability of the network, and decrease the expenses of its execution by removing unnecessary observations. The role of an optimal design is highlighted in deformation monitoring network due to the repeatability of these networks. The core design problem is how to define precision and reliability criteria. This paper proposes a solution, where the precision criterion is defined based on the precision of deformation parameters, i. e. precision of strain and differential rotations. A strain analysis can be performed to obtain some information about the possible deformation of a deformable object. In this study, we split an area into a number of three-dimensional finite elements with the help of the Delaunay triangulation and performed the strain analysis on each element. According to the obtained precision of deformation parameters in each element, the precision criterion of displacement detection at each network point is then determined. The developed criterion is implemented to optimize the observations from the Global Positioning System (GPS) in SkÃ¥ne monitoring network in Sweden. The network was established in 1989 and straddled the Tornquist zone, which is one of the most active faults in southern Sweden. The numerical results show that 17 out of all 21 possible GPS baseline observations are sufficient to detect minimum 3 mm displacement at each network point. Graph analysis of cell clusters forming vascular networks Alves, A. P.; Mesquita, O. N.; GÃ³mez-GardeÃ±es, J.; Agero, U. This manuscript describes the experimental observation of vasculogenesis in chick embryos by means of network analysis. The formation of the vascular network was observed in the area opaca of embryos from 40 to 55 h of development. In the area opaca endothelial cell clusters self-organize as a primitive and approximately regular network of capillaries. The process was observed by bright-field microscopy in control embryos and in embryos treated with Bevacizumab (Avastin), an antibody that inhibits the signalling of the vascular endothelial growth factor (VEGF). The sequence of images of the vascular growth were thresholded, and used to quantify the forming network in control and Avastin-treated embryos. This characterization is made by measuring vessels density, number of cell clusters and the largest cluster density. From the original images, the topology of the vascular network was extracted and characterized by means of the usual network metrics such as: the degree distribution, average clustering coefficient, average short path length and assortativity, among others. This analysis allows to monitor how the largest connected cluster of the vascular network evolves in time and provides with quantitative evidence of the disruptive effects that Avastin has on the tree structure of vascular networks. Detecting Network Communities: An Application to Phylogenetic Analysis Andrade, Roberto F. S.; Rocha-Neto, Ivan C.; Santos, Leonardo B. L.; de Santana, Charles N.; Diniz, Marcelo V. C.; LobÃ£o, Thierry Petit; GoÃ©s-Neto, AristÃ³teles; Pinho, Suani T. R.; El-Hani, Charbel N. This paper proposes a new method to identify communities in generally weighted complex networks and apply it to phylogenetic analysis. In this case, weights correspond to the similarity indexes among protein sequences, which can be used for network construction so that the network structure can be analyzed to recover phylogenetically useful information from its properties. The analyses discussed here are mainly based on the modular character of protein similarity networks, explored through the Newman-Girvan algorithm, with the help of the neighborhood matrix . The most relevant networks are found when the network topology changes abruptly revealing distinct modules related to the sets of organisms to which the proteins belong. Sound biological information can be retrieved by the computational routines used in the network approach, without using biological assumptions other than those incorporated by BLAST. Usually, all the main bacterial phyla and, in some cases, also some bacterial classes corresponded totally (100%) or to a great extent (>70%) to the modules. We checked for internal consistency in the obtained results, and we scored close to 84% of matches for community pertinence when comparisons between the results were performed. To illustrate how to use the network-based method, we employed data for enzymes involved in the chitin metabolic pathway that are present in more than 100 organisms from an original data set containing 1,695 organisms, downloaded from GenBank on May 19, 2007. A preliminary comparison between the outcomes of the network-based method and the results of methods based on Bayesian, distance, likelihood, and parsimony criteria suggests that the former is as reliable as these commonly used methods. We conclude that the network-based method can be used as a powerful tool for retrieving modularity information from weighted networks, which is useful for phylogenetic analysis. PMID:21573202 System analysis and planning of a gas distribution network Salas, Edwin F.M.; Farias, Helio Monteiro [AUTOMIND, Rio de Janeiro, RJ (Brazil); Costa, Carla V.R. [Universidade Salvador (UNIFACS), BA (Brazil) The increase in demand by gas consumers require that projects or improvements in gas distribution networks be made carefully and safely to ensure a continuous, efficient and economical supply. Gas distribution companies must ensure that the networks and equipment involved are defined and designed at the appropriate time to attend to the demands of the market. To do that a gas distribution network analysis and planning tool should use distribution networks and transmission models for the current situation and the future changes to be implemented. These models are used to evaluate project options and help in making appropriate decisions in order to minimize the capital investment in new components or simple changes in operational procedures. Gas demands are increasing and it is important that gas distribute design new distribution systems to ensure this growth, considering financial constraints of the company, as well as local legislation and regulation. In this study some steps of developing a flexible system that attends to those needs will be described. The analysis of distribution requires geographically referenced data for the models as well as an accurate connectivity and the attributes of the equipment. GIS systems are often used as a deposit center that holds the majority of this information. GIS systems are constantly updated as distribution network equipment is modified. The distribution network modeling gathered from this system ensures that the model represents the current network condition. The benefits of this architecture drastically reduce the creation and maintenance cost of the network models, because network components data are conveniently made available to populate the distribution network. This architecture ensures that the models are continually reflecting the reality of the distribution network. (author) Analysis and logical modeling of biological signaling transduction networks Sun, Zhongyao The study of network theory and its application span across a multitude of seemingly disparate fields of science and technology: computer science, biology, social science, linguistics, etc. It is the intrinsic similarities embedded in the entities and the way they interact with one another in these systems that link them together. In this dissertation, I present from both the aspect of theoretical analysis and the aspect of application three projects, which primarily focus on signal transduction networks in biology. In these projects, I assembled a network model through extensively perusing literature, performed model-based simulations and validation, analyzed network topology, and proposed a novel network measure. The application of network modeling to the system of stomatal opening in plants revealed a fundamental question about the process that has been left unanswered in decades. The novel measure of the redundancy of signal transduction networks with Boolean dynamics by calculating its maximum node-independent elementary signaling mode set accurately predicts the effect of single node knockout in such signaling processes. The three projects as an organic whole advance the understanding of a real system as well as the behavior of such network models, giving me an opportunity to take a glimpse at the dazzling facets of the immense world of network science. Major component analysis of dynamic networks of physiologic organ interactions Liu, Kang K L; Ma, Qianli D Y; Ivanov, Plamen Ch; Bartsch, Ronny P The human organism is a complex network of interconnected organ systems, where the behavior of one system affects the dynamics of other systems. Identifying and quantifying dynamical networks of diverse physiologic systems under varied conditions is a challenge due to the complexity in the output dynamics of the individual systems and the transient and nonlinear characteristics of their coupling. We introduce a novel computational method based on the concept of time delay stability and major component analysis to investigate how organ systems interact as a network to coordinate their functions. We analyze a large database of continuously recorded multi-channel physiologic signals from healthy young subjects during night-time sleep. We identify a network of dynamic interactions between key physiologic systems in the human organism. Further, we find that each physiologic state is characterized by a distinct network structure with different relative contribution from individual organ systems to the global network dynamics. Specifically, we observe a gradual decrease in the strength of coupling of heart and respiration to the rest of the network with transition from wake to deep sleep, and in contrast, an increased relative contribution to network dynamics from chin and leg muscle tone and eye movement, demonstrating a robust association between network topology and physiologic function. (paper) A systematic review protocol: social network analysis of tobacco use. Maddox, Raglan; Davey, Rachel; Lovett, Ray; van der Sterren, Anke; Corbett, Joan; Cochrane, Tom Tobacco use is the single most preventable cause of death in the world. Evidence indicates that behaviours such as tobacco use can influence social networks, and that social network structures can influence behaviours. Social network analysis provides a set of analytic tools to undertake methodical analysis of social networks. We will undertake a systematic review to provide a comprehensive synthesis of the literature regarding social network analysis and tobacco use. The review will answer the following research questions: among participants who use tobacco, does social network structure/position influence tobacco use? Does tobacco use influence peer selection? Does peer selection influence tobacco use? We will follow the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines and search the following databases for relevant articles: CINAHL (Cumulative Index to Nursing and Allied Health Literature); Informit Health Collection; PsycINFO; PubMed/MEDLINE; Scopus/Embase; Web of Science; and the Wiley Online Library. Keywords include tobacco; smoking; smokeless; cigarettes; cigar and 'social network' and reference lists of included articles will be hand searched. Studies will be included that provide descriptions of social network analysis of tobacco use.Qualitative, quantitative and mixed method data that meets the inclusion criteria for the review, including methodological rigour, credibility and quality standards, will be synthesized using narrative synthesis. Results will be presented using outcome statistics that address each of the research questions. This systematic review will provide a timely evidence base on the role of social network analysis of tobacco use, forming a basis for future research, policy and practice in this area. This systematic review will synthesise the evidence, supporting the hypothesis that social network structures can influence tobacco use. This will also include exploring the relationship between social Network Analysis of Commuting Flows: A Comparative Static Approach to German Data Patuelli, R.; Reggiani, A.; Nijkamp, P.; Bade, F-J The analysis of complex networks has recently received considerable attention. The work by Albert and BarabÃ¡si presented a research challenge to network analysis, that is, growth of the network. The present paper offers a network analysis of the spatial commuting network in Germany. First, we study Investment Valuation Analysis with Artificial Neural Networks HÃ¼seyin Ä°NCE Full Text Available This paper shows that discounted cash flow and net present value, which are traditional investment valuation models, can be combined with artificial neural network model forecasting. The main inputs for the valuation models, such as revenue, costs, capital expenditure, and their growth rates, are heavily related to sector dynamics and macroeconomics. The growth rates of those inputs are related to inflation and exchange rates. Therefore, predicting inflation and exchange rates is a critical issue for the valuation output. In this paper, the Turkish economyâ€™s inflation rate and the exchange rate of USD/TRY are forecast by artificial neural networks and implemented to the discounted cash flow model. Finally, the results are benchmarked with conventional practices. Network Configuration Analysis for Formation Flying Satellites Knoblock, Eric J.; Wallett, Thomas M.; Konangi, Vijay K.; Bhasin, Kul B. The performance of two networks to support autonomous multi-spacecraft formation flying systems is presented. Both systems are comprised of a ten-satellite formation, with one of the satellites designated as the central or 'mother ship.' All data is routed through the mother ship to the terrestrial network. The first system uses a TCP/EP over ATM protocol architecture within the formation, and the second system uses the IEEE 802.11 protocol architecture within the formation. The simulations consist of file transfers using either the File Transfer Protocol (FTP) or the Simple Automatic File Exchange (SAFE) Protocol. The results compare the IP queuing delay, IP queue size and IP processing delay at the mother ship as well as end-to-end delay for both systems. In all cases, using IEEE 802.11 within the formation yields less delay. Also, the throughput exhibited by SAFE is better than FTP. Semantic web for integrated network analysis in biomedicine. Chen, Huajun; Ding, Li; Wu, Zhaohui; Yu, Tong; Dhanapalan, Lavanya; Chen, Jake Y The Semantic Web technology enables integration of heterogeneous data on the World Wide Web by making the semantics of data explicit through formal ontologies. In this article, we survey the feasibility and state of the art of utilizing the Semantic Web technology to represent, integrate and analyze the knowledge in various biomedical networks. We introduce a new conceptual framework, semantic graph mining, to enable researchers to integrate graph mining with ontology reasoning in network data analysis. Through four case studies, we demonstrate how semantic graph mining can be applied to the analysis of disease-causal genes, Gene Ontology category cross-talks, drug efficacy analysis and herb-drug interactions analysis. A Network Text Analysis of David Ayerâ€™s Fury Starling David Hunter Full Text Available Network Text Analysis (NTA involves the creation of networks of words and/or concepts from linguistic data. Its key insight is that the position of words and concepts in a text network provides vital clues to the central and underlying themes of the text as a whole. Recent research has relied on inductive approaches to identify these themes. In this study we demonstrate a deductive approach that we apply to the screenplay of the 2014 World War II-era film Fury. Specifically, we first use genre expectations theory to establish prior expectations as to the key themes associated with war films. We then empirically test whether words and concepts associated with the most influentially-positioned nodes are consistent with themes common to the war-film genre. As predicted, we find that words and concepts associated with the least constrained nodes in the text network were significantly more likely to be associated with the war, action, and biography genres and significantly less likely to be associated with the mystery, science-fiction, fantasy, and film-noir genres. Keywords: content analysis, text analysis, network text analysis, semantic network analysis, film studies, screenplay, screenwriting, war movies, World War II, tanks Measurements and analysis of online social networks GonzÃ¡lez SÃ¡nchez, Roberto MenciÃ³n Internacional Online Social Networks (OSNs) have become the most used Internet applications attracting hundreds of millions active users every day. The large amount of valuable information in OSNs (not even before available) has attracted the research community to design sophisticated techniques to collect, process, interpret and apply these data into a large range of disciplines including Sociology, Marketing, Computer Science, etc. This thesis presents a series of ... Analysis and design of networked control systems You, Keyou; Xie, Lihua This monograph focuses on characterizing the stability and performance consequences of inserting limited-capacity communication networks within a control loop. The text shows how integration of the ideas of control and estimation with those of communication and information theory can be used to provide important insights concerning several fundamental problems such as: Â·Â Â Â Â Â Â Â Â minimum data rate for stabilization of linear systems over noisy channels; Â·Â Â Â Â Â Â Â Â minimum network requirement for stabilization of linear systems over fading channels; and Â·Â Â Â Â Â Â Â Â stability of Kalman filtering with intermittent observations. A fundamental link is revealed between the topological entropy of linear dynamical systems and the capacities of communication channels. The design of a logarithmic quantizer for the stabilization of linear systems under various network environments is also extensively discussed and solutions to many problems of Kalman filtering with intermittent observations are de... Qualitative Analysis of Commercial Social Network Profiles Melendez, Lester; Wolfson, Ouri; Adjouadi, Malek; Rishe, Naphtali Social-networking sites have become an integral part of many users' daily internet routine. Commercial enterprises have been quick to recognize this and are subsequently creating profiles for many of their products and services. Commercial enterprises use social network profiles to target and interact with potential customers as well as to provide a gateway for users of the product or service to interact with each other. Many commercial enterprises use the statistics from their product or service's social network profile to tout the popularity and success of the product or service being showcased. They will use statistics such as number of friends, number of daily visits, number of interactions, and other similar measurements to quantify their claims. These statistics are often not a clear indication of the true popularity and success of the product. In this chapter the term product is used to refer to any tangible or intangible product, service, celebrity, personality, film, book, or other entity produced by a commercial enterprise. Network analysis: An innovative framework for understanding eating disorder psychopathology. Smith, Kathryn E; Crosby, Ross D; Wonderlich, Stephen A; Forbush, Kelsie T; Mason, Tyler B; Moessner, Markus Network theory and analysis is an emerging approach in psychopathology research that has received increasing attention across fields of study. In contrast to medical models or latent variable approaches, network theory suggests that psychiatric syndromes result from systems of causal and reciprocal symptom relationships. Despite the promise of this approach to elucidate key mechanisms contributing to the development and maintenance of eating disorders (EDs), thus far, few applications of network analysis have been tested in ED samples. We first present an overview of network theory, review the existing findings in the ED literature, and discuss the limitations of this literature to date. In particular, the reliance on cross-sectional designs, use of single-item self-reports of symptoms, and instability of results have raised concern about the inferences that can be made from network analyses. We outline several areas to address in future ED network analytic research, which include the use of prospective designs and adoption of multimodal assessment methods. Doing so will provide a clearer understanding of whether network analysis can enhance our current understanding of ED psychopathology and inform clinical interventions. Â© 2018 Wiley Periodicals, Inc. Identification of Conserved Moieties in Metabolic Networks by Graph Theoretical Analysis of Atom Transition Networks HaraldsdÃ³ttir, Hulda S.; Fleming, Ronan M. T. Conserved moieties are groups of atoms that remain intact in all reactions of a metabolic network. Identification of conserved moieties gives insight into the structure and function of metabolic networks and facilitates metabolic modelling. All moiety conservation relations can be represented as nonnegative integer vectors in the left null space of the stoichiometric matrix corresponding to a biochemical network. Algorithms exist to compute such vectors based only on reaction stoichiometry but their computational complexity has limited their application to relatively small metabolic networks. Moreover, the vectors returned by existing algorithms do not, in general, represent conservation of a specific moiety with a defined atomic structure. Here, we show that identification of conserved moieties requires data on reaction atom mappings in addition to stoichiometry. We present a novel method to identify conserved moieties in metabolic networks by graph theoretical analysis of their underlying atom transition networks. Our method returns the exact group of atoms belonging to each conserved moiety as well as the corresponding vector in the left null space of the stoichiometric matrix. It can be implemented as a pipeline of polynomial time algorithms. Our implementation completes in under five minutes on a metabolic network with more than 4,000 mass balanced reactions. The scalability of the method enables extension of existing applications for moiety conservation relations to genome-scale metabolic networks. We also give examples of new applications made possible by elucidating the atomic structure of conserved moieties. PMID:27870845 Growth of cortical neuronal network in vitro: Modeling and analysis Lai, P.-Y.; Jia, L. C.; Chan, C. K. We present a detailed analysis and theoretical growth models to account for recent experimental data on the growth of cortical neuronal networks in vitro [Phys. Rev. Lett. 93, 088101 (2004)]. The experimentally observed synchronized firing frequency of a well-connected neuronal network is shown to be proportional to the mean network connectivity. The growth of the network is consistent with the model of an early enhanced growth of connection, but followed by a retarded growth once the synchronized cluster is formed. Microscopic models with dominant excluded volume interactions are consistent with the observed exponential decay of the mean connection probability as a function of the mean network connectivity. The biological implications of the growth model are also discussed Modeling and Analysis of New Products Diffusion on Heterogeneous Networks Shuping Li Full Text Available We present a heterogeneous networks model with the awareness stage and the decision-making stage to explain the process of new products diffusion. If mass media is neglected in the decision-making stage, there is a threshold whether the innovation diffusion is successful or not, or else it is proved that the network model has at least one positive equilibrium. For networks with the power-law degree distribution, numerical simulations confirm analytical results, and also at the same time, by numerical analysis of the influence of the network structure and persuasive advertisements on the density of adopters, we give two different products propagation strategies for two classes of nodes in scale-free networks. Sovereign public debt crisis in Europe. A network analysis Matesanz, David; Ortega, Guillermo J. In this paper we analyse the evolving network structure of the quarterly public debt-to-GDP ratio from 2000 to 2014. By applying tools and concepts coming from complex systems we study the effects of the global financial crisis over public debt network connections and communities. Two main results arise from this analysis: firstly, countries public debts tend to synchronize their evolution, increasing global connectivity in the network and dramatically decreasing the number of communities. Secondly, a disruption in previous structure is observed at the time of the shock, emerging a more centralized and less diversify network topological organization which might be more prone to suffer contagion effects. This last fact is evidenced by an increasing tendency in countries of similar level of public debt to be connected between them, which we have quantified by the network assortativity. Network clustering coefficient approach to DNA sequence analysis Gerhardt, Guenther J.L. [Universidade Federal do Rio Grande do Sul-Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350/sala 2040/90035-003 Porto Alegre (Brazil); Departamento de Fisica e Quimica da Universidade de Caxias do Sul, Rua Francisco Getulio Vargas 1130, 95001-970 Caxias do Sul (Brazil); Lemke, Ney [Programa Interdisciplinar em Computacao Aplicada, Unisinos, Av. Unisinos, 950, 93022-000 Sao Leopoldo, RS (Brazil); Corso, Gilberto [Departamento de Biofisica e Farmacologia, Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Campus Universitario, 59072 970 Natal, RN (Brazil)]. E-mail: corso@dfte.ufrn.br In this work we propose an alternative DNA sequence analysis tool based on graph theoretical concepts. The methodology investigates the path topology of an organism genome through a triplet network. In this network, triplets in DNA sequence are vertices and two vertices are connected if they occur juxtaposed on the genome. We characterize this network topology by measuring the clustering coefficient. We test our methodology against two main bias: the guanine-cytosine (GC) content and 3-bp (base pairs) periodicity of DNA sequence. We perform the test constructing random networks with variable GC content and imposed 3-bp periodicity. A test group of some organisms is constructed and we investigate the methodology in the light of the constructed random networks. We conclude that the clustering coefficient is a valuable tool since it gives information that is not trivially contained in 3-bp periodicity neither in the variable GC content. Financial Analysis of Hastily-Formed Networks high-profile 101 Elvik Rune , â€œCost-benefit analysis of ambulance and rescue helicopters in Norway...Systems Acquisition and Program Management. Rune , Elvik, â€œCost-benefit analysis of ambulance and rescue helicopters in Norway: reflections on Compartmentalization analysis using discrete fracture network models La Pointe, P.R.; Eiben, T.; Dershowitz, W. [Golder Associates, Redmond, VA (United States); Wadleigh, E. [Marathon Oil Co., Midland, TX (United States) This paper illustrates how Discrete Fracture Network (DFN) technology can serve as a basis for the calculation of reservoir engineering parameters for the development of fractured reservoirs. It describes the development of quantitative techniques for defining the geometry and volume of structurally controlled compartments. These techniques are based on a combination of stochastic geometry, computational geometry, and graph the theory. The parameters addressed are compartment size, matrix block size and tributary drainage volume. The concept of DFN models is explained and methodologies to compute these parameters are demonstrated. Development and Analysis of a VANET Network Corral Zapata, Adrian Se denomina red vehicular ad hoc (en inglÃ©s Vehicular Ad Hoc Network, VANET) a una red de comunicaciÃ³n inalÃ¡mbrica para la transmisiÃ³n de informaciÃ³n entre vehÃculos y elementos de la infraestructura de la carretera. La tecnologÃa utilizada se engloba dentro de los sistemas inteligentes de transporte (en inglÃ©s Intelligent Transport Systems, ITS). El objetivo principal de las redes de comunicaciÃ³n vehiculares son la transmisiÃ³n de informaciÃ³n Ãºtil entre los elementos presentes en la carretera... Social Network Analysis and Critical Realism Buch-Hansen, Hubert in relation to established philosophies of science. This article argues that there is a tension between applied and methods-oriented SNA studies, on the one hand, and those addressing the social-theoretical nature and implications of networks, on the other. The former, in many cases, exhibits positivist...... tendencies, whereas the latter incorporate a number of assumptions that are directly compatible with core critical realist views on the nature of social reality and knowledge. This article suggests that SNA may be detached from positivist social science and come to constitute a valuable instrument...... in the critical realist toolbox.... Spatial Distribution Characteristics of Healthcare Facilities in Nanjing: Network Point Pattern Analysis and Correlation Analysis Jianhua Ni Full Text Available The spatial distribution of urban service facilities is largely constrained by the road network. In this study, network point pattern analysis and correlation analysis were used to analyze the relationship between road network and healthcare facility distribution. The weighted network kernel density estimation method proposed in this study identifies significant differences between the outside and inside areas of the Ming city wall. The results of network K-function analysis show that private hospitals are more evenly distributed than public hospitals, and pharmacy stores tend to cluster around hospitals along the road network. After computing the correlation analysis between different categorized hospitals and street centrality, we find that the distribution of these hospitals correlates highly with the street centralities, and that the correlations are higher with private and small hospitals than with public and large hospitals. The comprehensive analysis results could help examine the reasonability of existing urban healthcare facility distribution and optimize the location of new healthcare facilities. SNAP: A General Purpose Network Analysis and Graph Mining Library. Leskovec, Jure; SosiÄ�, Rok Large networks are becoming a widely used abstraction for studying complex systems in a broad set of disciplines, ranging from social network analysis to molecular biology and neuroscience. Despite an increasing need to analyze and manipulate large networks, only a limited number of tools are available for this task. Here, we describe Stanford Network Analysis Platform (SNAP), a general-purpose, high-performance system that provides easy to use, high-level operations for analysis and manipulation of large networks. We present SNAP functionality, describe its implementational details, and give performance benchmarks. SNAP has been developed for single big-memory machines and it balances the trade-off between maximum performance, compact in-memory graph representation, and the ability to handle dynamic graphs where nodes and edges are being added or removed over time. SNAP can process massive networks with hundreds of millions of nodes and billions of edges. SNAP offers over 140 different graph algorithms that can efficiently manipulate large graphs, calculate structural properties, generate regular and random graphs, and handle attributes and meta-data on nodes and edges. Besides being able to handle large graphs, an additional strength of SNAP is that networks and their attributes are fully dynamic, they can be modified during the computation at low cost. SNAP is provided as an open source library in C++ as well as a module in Python. We also describe the Stanford Large Network Dataset, a set of social and information real-world networks and datasets, which we make publicly available. The collection is a complementary resource to our SNAP software and is widely used for development and benchmarking of graph analytics algorithms. Studying Policy Transfer through the Lens of Social Network Analysis StaunÃ¦s, Dorthe; BrÃ¸gger, Katja; Steiner-Khamsi, Gita Studying Policy Transfer through the Lens of Social Network Analysis The panelists present the findings of a joint empirical research project carried out at Aarhus University (DPU/Copenhagen) and at Teachers College, Columbia University (New York). The research project succeeded to identify...... discursive networks of political stakeholders and policy advisors that were considered key actors in the Danish school reform. The research team investigated how these networks interrelate, change over time, and represent different constituents (government, academe, business), at times contradicting...... or collaborating with each other, respectively. Against the backdrop of globalization studies in comparative education, the research project attempted to identify borrowers, translators, and brokers of educational reform drawing on a complementary set of expertise from social network analysis methodology (Oren... Performability indicators for the traffic analysis of wide area networks Tsopelas, Panagiotis; Platis, Agapios In connecting computing networks, reliability term is strongly related to the availability of connections of Wide Area networks (WANs) or Local Area networks (LANs). In this paper we will examine the network connections activity of a Greek University in order to provide two sources of information: The Quantity of Information Not Delivered (QIND) and the Information Flow Interruption (IFI). These indicators will provide us with the inference of information from observable characteristics of data flow(s), even when the data is encrypted or otherwise not directly available (traffic), which is lost due to failures or upgrades inside this network. The reliability analysis is obtained by collecting the network failures data (duration and frequency) and traffic (total and average) for a specified period of 1 year. It is assumed that the numerical analysis is based on the fact that the lifetime follows and exponential distribution (here as we are working on discrete time the distribution must be the geometric distribution). Hence a Markov chain model seems suitable for modelling the functioning of this system. An algorithm concentrates the results in a transition probability matrix and calculates the reward functions for the QIND/IFI indicators with the use of the power method. Finally, the application part provides an example of how final results can be used to evaluate the observed network Service network design of bike sharing systems analysis and optimization Vogel, Patrick This monograph presents a tactical planning approach for service network design in metropolitan areas. Designing the service network requires the suitable aggregation of demand data as well as the anticipation of operational relocation decisions. To this end, an integrated approach of data analysis and mathematical optimization is introduced. The book also includes a case study based on real-world data to demonstrate the benefit of the proposed service network design approach. The target audience comprises primarily research experts in the field of traffic engineering, but the book may also be beneficial for graduate students. Network meta-analysis of disconnected networks: How dangerous are random baseline treatment effects? BÃ©liveau, Audrey; Goring, Sarah; Platt, Robert W; Gustafson, Paul In network meta-analysis, the use of fixed baseline treatment effects (a priori independent) in a contrast-based approach is regularly preferred to the use of random baseline treatment effects (a priori dependent). That is because, often, there is not a need to model baseline treatment effects, which carry the risk of model misspecification. However, in disconnected networks, fixed baseline treatment effects do not work (unless extra assumptions are made), as there is not enough information in the data to update the prior distribution on the contrasts between disconnected treatments. In this paper, we investigate to what extent the use of random baseline treatment effects is dangerous in disconnected networks. We take 2 publicly available datasets of connected networks and disconnect them in multiple ways. We then compare the results of treatment comparisons obtained from a Bayesian contrast-based analysis of each disconnected network using random normally distributed and exchangeable baseline treatment effects to those obtained from a Bayesian contrast-based analysis of their initial connected network using fixed baseline treatment effects. For the 2 datasets considered, we found that the use of random baseline treatment effects in disconnected networks was appropriate. Because those datasets were not cherry-picked, there should be other disconnected networks that would benefit from being analyzed using random baseline treatment effects. However, there is also a risk for the normality and exchangeability assumption to be inappropriate in other datasets even though we have not observed this situation in our case study. We provide code, so other datasets can be investigated. Copyright Â© 2017 John Wiley & Sons, Ltd. Google matrix analysis of C.elegans neural network Kandiah, V., E-mail: kandiah@irsamc.ups-tlse.fr; Shepelyansky, D.L., E-mail: dima@irsamc.ups-tlse.fr We study the structural properties of the neural network of the C.elegans (worm) from a directed graph point of view. The Google matrix analysis is used to characterize the neuron connectivity structure and node classifications are discussed and compared with physiological properties of the cells. Our results are obtained by a proper definition of neural directed network and subsequent eigenvector analysis which recovers some results of previous studies. Our analysis highlights particular sets of important neurons constituting the core of the neural system. The applications of PageRank, CheiRank and ImpactRank to characterization of interdependency of neurons are discussed. Kandiah, V.; Shepelyansky, D.L. Genome-wide expression of transcriptomes and their co-expression pattern in subtropical maize (Zea mays L. under waterlogging stress. Nepolean Thirunavukkarasu Full Text Available Waterlogging causes extensive damage to maize crops in tropical and subtropical regions. The identification of tolerance genes and their interactions at the molecular level will be helpful to engineer tolerant genotypes. A whole-genome transcriptome assay revealed the specific role of genes in response to waterlogging stress in susceptible and tolerant genotypes. Genes involved in the synthesis of ethylene and auxin, cell wall metabolism, activation of G-proteins and formation of aerenchyma and adventitious roots, were upregulated in the tolerant genotype. Many transcription factors, particularly ERFs, MYB, HSPs, MAPK, and LOB-domain protein were involved in regulation of these traits. Genes responsible for scavenging of ROS generated under stress were expressed along with those involved in carbohydrate metabolism. The physical locations of 21 genes expressed in the tolerant genotype were found to correspond with the marker intervals of known QTLs responsible for development of adaptive traits. Among the candidate genes, most showed synteny with genes of sorghum and foxtail millet. Co-expression analysis of 528 microarray samples including 16 samples from the present study generated seven functional modules each in the two genotypes, with differing characteristics. In the tolerant genotype, stress genes were co-expressed along with peroxidase and fermentation pathway genes. An Analysis of Construction Accident Factors Based on Bayesian Network Yunsheng Zhao; Jinyong Pei In this study, we have an analysis of construction accident factors based on bayesian network. Firstly, accidents cases are analyzed to build Fault Tree method, which is available to find all the factors causing the accidents, then qualitatively and quantitatively analyzes the factors with Bayesian network method, finally determines the safety management program to guide the safety operations. The results of this study show that bad condition of geological environment has the largest posterio... Analysis of organizational culture with social network models Titov, S. Organizational culture is nowadays an object of numerous scientific papers. However, only marginal part of existing research attempts to use the formal models of organizational cultures. The lack of organizational culture models significantly limits the further research in this area and restricts the application of the theory to practice of organizational culture change projects. The article consists of general views on potential application of network models and social network analysis to th... Stability analysis for cellular neural networks with variable delays Zhang Qiang; Wei Xiaopeng; Xu Jin Some sufficient conditions for the global exponential stability of cellular neural networks with variable delay are obtained by means of a method based on delay differential inequality. The method, which does not make use of Lyapunov functionals, is simple and effective for the stability analysis of neural networks with delay. Some previously established results in the literature are shown to be special cases of the presented result Time analysis of interconnection network implemented on the honeycomb architecture Milutinovic, D [Inst. Michael Pupin, Belgrade (Yugoslavia) Problems of time domains analysis of the mapping of interconnection networks for parallel processing on one form of uniform massively parallel architecture of the cellular type are considered. The results of time analysis are discussed. It is found that changing the technology results in changing the mapping rules. 17 refs. Identification of Gene Modules Associated with Low Temperatures Response in Bambara Groundnut by Network-Based Analysis. Venkata Suresh Bonthala Full Text Available Bambara groundnut (Vigna subterranea (L. Verdc. is an African legume and is a promising underutilized crop with good seed nutritional values. Low temperature stress in a number of African countries at night, such as Botswana, can effect the growth and development of bambara groundnut, leading to losses in potential crop yield. Therefore, in this study we developed a computational pipeline to identify and analyze the genes and gene modules associated with low temperature stress responses in bambara groundnut using the cross-species microarray technique (as bambara groundnut has no microarray chip coupled with network-based analysis. Analyses of the bambara groundnut transcriptome using cross-species gene expression data resulted in the identification of 375 and 659 differentially expressed genes (p<0.01 under the sub-optimal (23Â°C and very sub-optimal (18Â°C temperatures, respectively, of which 110 genes are commonly shared between the two stress conditions. The construction of a Highest Reciprocal Rank-based gene co-expression network, followed by its partition using a Heuristic Cluster Chiseling Algorithm resulted in 6 and 7 gene modules in sub-optimal and very sub-optimal temperature stresses being identified, respectively. Modules of sub-optimal temperature stress are principally enriched with carbohydrate and lipid metabolic processes, while most of the modules of very sub-optimal temperature stress are significantly enriched with responses to stimuli and various metabolic processes. Several transcription factors (from MYB, NAC, WRKY, WHIRLY & GATA classes that may regulate the downstream genes involved in response to stimulus in order for the plant to withstand very sub-optimal temperature stress were highlighted. The identified gene modules could be useful in breeding for low-temperature stress tolerant bambara groundnut varieties. Network analysis of PTSD symptoms following mass violence. Sullivan, Connor P; Smith, Andrew J; Lewis, Michael; Jones, Russell T Network analysis is a useful tool for understanding how symptoms interact with one another to influence psychopathology. However, this analytic strategy has not been fully utilized in the PTSD field. The current study utilized network analysis to examine connectedness and strength among PTSD symptoms (employing both partial correlation and regression network analyses) among a community sample of students exposed to the 2007 Virginia Tech shootings. Respondents (N = 4,639) completed online surveys 3-4 months postshootings, with PTSD symptom severity measured via the Trauma Symptom Questionnaire. Data were analyzed via adaptive least absolute shrinkage and selection operator (LASSO) and relative importance networks, as well as Dijkstra's algorithm to identify the shortest path from each symptom to all other symptoms. Relative importance network analysis revealed that intrusive thoughts had the strongest influence on other symptoms (i.e., had many strong connections [highest outdegree]) while computing Dijkstra's algorithm indicated that anger produced the shortest path to all other symptoms (i.e., the strongest connections to all other symptoms). Findings suggest that anger or intrusion likely play a crucial role in the development and maintenance of PTSD (i.e., are more influential within the network than are other symptoms). (PsycINFO Database Record (c) 2018 APA, all rights reserved). Transient analysis for PWR reactor core using neural networks predictors Gueray, B.S. In this study, transient analysis for a Pressurized Water Reactor core has been performed. A lumped parameter approximation is preferred for that purpose, to describe the reactor core together with mechanism which play an important role in dynamic analysis. The dynamic behavior of the reactor core during transients is analyzed considering the transient initiating events, wich are an essential part of Safety Analysis Reports. several transients are simulated based on the employed core model. Simulation results are in accord the physical expectations. A neural network is developed to predict the future response of the reactor core, in advance. The neural network is trained using the simulation results of a number of representative transients. Structure of the neural network is optimized by proper selection of transfer functions for the neurons. Trained neural network is used to predict the future responses following an early observation of the changes in system variables. Estimated behaviour using the neural network is in good agreement with the simulation results for various for types of transients. Results of this study indicate that the designed neural network can be used as an estimator of the time dependent behavior of the reactor core under transient conditions Extracting neuronal functional network dynamics via adaptive Granger causality analysis. Sheikhattar, Alireza; Miran, Sina; Liu, Ji; Fritz, Jonathan B; Shamma, Shihab A; Kanold, Patrick O; Babadi, Behtash Quantifying the functional relations between the nodes in a network based on local observations is a key challenge in studying complex systems. Most existing time series analysis techniques for this purpose provide static estimates of the network properties, pertain to stationary Gaussian data, or do not take into account the ubiquitous sparsity in the underlying functional networks. When applied to spike recordings from neuronal ensembles undergoing rapid task-dependent dynamics, they thus hinder a precise statistical characterization of the dynamic neuronal functional networks underlying adaptive behavior. We develop a dynamic estimation and inference paradigm for extracting functional neuronal network dynamics in the sense of Granger, by integrating techniques from adaptive filtering, compressed sensing, point process theory, and high-dimensional statistics. We demonstrate the utility of our proposed paradigm through theoretical analysis, algorithm development, and application to synthetic and real data. Application of our techniques to two-photon Ca 2+ imaging experiments from the mouse auditory cortex reveals unique features of the functional neuronal network structures underlying spontaneous activity at unprecedented spatiotemporal resolution. Our analysis of simultaneous recordings from the ferret auditory and prefrontal cortical areas suggests evidence for the role of rapid top-down and bottom-up functional dynamics across these areas involved in robust attentive behavior. Analysis of the experimental positron lifetime spectra by neural networks Avdic, S.; Chakarova, R.; Pazsit, I. This paper deals with the analysis of experimental positron lifetime spectra in polymer materials by using various algorithms of neural networks. A method based on the use of artificial neural networks for unfolding the mean lifetime and intensity of the spectral components of simulated positron lifetime spectra was previously suggested and tested on simulated data [Pazsit et al., Applied Surface Science, 149 (1998), 97]. In this work, the applicability of the method to the analysis of experimental positron spectra has been verified in the case of spectra from polymer materials with three components. It has been demonstrated that the backpropagation neural network can determine the spectral parameters with a high accuracy and perform the decomposition of lifetimes which differ by 10% or more. The backpropagation network has not been suitable for the identification of both the parameters and the number of spectral components. Therefore, a separate artificial neural network module has been designed to solve the classification problem. Module types based on self-organizing map and learning vector quantization algorithms have been tested. The learning vector quantization algorithm was found to have better performance and reliability. A complete artificial neural network analysis tool of positron lifetime spectra has been constructed to include a spectra classification module and parameter evaluation modules for spectra with a different number of components. In this way, both flexibility and high resolution can be achieved. (author) Application of neural networks to quantitative spectrometry analysis Pilato, V.; Tola, F.; Martinez, J.M.; Huver, M. Accurate quantitative analysis of complex spectra (fission and activation products), relies upon experts' knowledge. In some cases several hours, even days of tedious calculations are needed. This is because current software is unable to solve deconvolution problems when several rays overlap. We have shown that such analysis can be correctly handled by a neural network, and the procedure can be automated with minimum laboratory measurements for networks training, as long as all the elements of the analysed solution figure in the training set and provided that adequate scaling of input data is performed. Once the network has been trained, analysis is carried out in a few seconds. On submitting to a test between several well-known laboratories, where unknown quantities of 57 Co, 58 Co, 85 Sr, 88 Y, 131 I, 139 Ce, 141 Ce present in a sample had to be determined, the results yielded by our network classed it amongst the best. The method is described, including experimental device and measures, training set designing, relevant input parameters definition, input data scaling and networks training. Main results are presented together with a statistical model allowing networks error prediction Bank-firm credit network in Japan: an analysis of a bipartite network. Marotta, Luca; MiccichÃ¨, Salvatore; Fujiwara, Yoshi; Iyetomi, Hiroshi; Aoyama, Hideaki; Gallegati, Mauro; Mantegna, Rosario N We investigate the networked nature of the Japanese credit market. Our investigation is performed with tools of network science. In our investigation we perform community detection with an algorithm which is identifying communities composed of both banks and firms. We show that the communities obtained by directly working on the bipartite network carry information about the networked nature of the Japanese credit market. Our analysis is performed for each calendar year during the time period from 1980 to 2011. To investigate the time evolution of the networked structure of the credit market we introduce a new statistical method to track the time evolution of detected communities. We then characterize the time evolution of communities by detecting for each time evolving set of communities the over-expression of attributes of firms and banks. Specifically, we consider as attributes the economic sector and the geographical location of firms and the type of banks. In our 32-year-long analysis we detect a persistence of the over-expression of attributes of communities of banks and firms together with a slow dynamic of changes from some specific attributes to new ones. Our empirical observations show that the credit market in Japan is a networked market where the type of banks, geographical location of firms and banks, and economic sector of the firm play a role in shaping the credit relationships between banks and firms. Bank-Firm Credit Network in Japan: An Analysis of a Bipartite Network Marotta, Luca; MiccichÃ¨, Salvatore; Fujiwara, Yoshi; Iyetomi, Hiroshi; Aoyama, Hideaki; Gallegati, Mauro; Mantegna, Rosario N. We investigate the networked nature of the Japanese credit market. Our investigation is performed with tools of network science. In our investigation we perform community detection with an algorithm which is identifying communities composed of both banks and firms. We show that the communities obtained by directly working on the bipartite network carry information about the networked nature of the Japanese credit market. Our analysis is performed for each calendar year during the time period from 1980 to 2011. To investigate the time evolution of the networked structure of the credit market we introduce a new statistical method to track the time evolution of detected communities. We then characterize the time evolution of communities by detecting for each time evolving set of communities the over-expression of attributes of firms and banks. Specifically, we consider as attributes the economic sector and the geographical location of firms and the type of banks. In our 32-year-long analysis we detect a persistence of the over-expression of attributes of communities of banks and firms together with a slow dynamic of changes from some specific attributes to new ones. Our empirical observations show that the credit market in Japan is a networked market where the type of banks, geographical location of firms and banks, and economic sector of the firm play a role in shaping the credit relationships between banks and firms. PMID:25933413 Energy and exergy analysis of low temperature district heating network Li, Hongwei; Svendsen, Svend Low temperature district heating with reduced network supply and return temperature provides better match of the low quality building heating demand and the low quality heating supply from waste heat or renewable energy. In this paper, a hypothetical low temperature district heating network is designed to supply heating for 30 low energy detached residential houses. The network operational supply/return temperature is set as 55 Â°C/25 Â°C, which is in line with a pilot project carried out in Denmark. Two types of in-house substations are analyzed to supply the consumer domestic hot water demand. The space heating demand is supplied through floor heating in the bathroom and low temperature radiators in the rest of rooms. The network thermal and hydraulic conditions are simulated under steady state. A district heating network design and simulation code is developed to incorporate the network optimization procedure and the network simultaneous factor. Through the simulation, the overall system energy and exergy efficiencies are calculated and the exergy losses for the major district heating system components are identified. Based on the results, suggestions are given to further reduce the system energy/exergy losses and increase the quality match between the consumer heating demand and the district heating supply. -- Highlights: â–º Exergy and energy analysis for low and medium temperature district heating systems. â–º Different district heating network dimensioning methods are analyzed. â–º Major exergy losses are identified in the district heating network and the in-house substations. â–º Advantages to apply low temperature district heating are highlighted through exergy analysis. â–º The influence of thermal by-pass on system exergy/energy performance is analyzed. Mobile networks for biometric data analysis Madrid, Natividad; Seepold, Ralf; Orcioni, Simone This book showcases new and innovative approaches to biometric data capture and analysis, focusing especially on those that are characterized by non-intrusiveness, reliable prediction algorithms, and high user acceptance. It comprises the peer-reviewed papers from the international workshop on the subject that was held in Ancona, Italy, in October 2014 and featured sessions on ICT for health care, biometric data in automotive and home applications, embedded systems for biometric data analysis, biometric data analysis: EMG and ECG, and ICT for gait analysis. The background to the book is the challenge posed by the prevention and treatment of common, widespread chronic diseases in modern, aging societies. Capture of biometric data is a cornerstone for any analysis and treatment strategy. The latest advances in sensor technology allow accurate data measurement in a non-intrusive way, and in many cases it is necessary to provide online monitoring and real-time data capturing to support a patientâ€™s prevention pl... G-NEST: A gene neighborhood scoring tool to identify co-conserved, co-expressed genes In previous studies, gene neighborhoods--spatial clusters of co-expressed genes in the genome--have been defined using arbitrary rules such as requiring adjacency, a minimum number of genes, a fixed window size, or a minimum expression level. In the current study, we developed a Gene Neighborhood Sc... MIDBRAIN CATECHOLAMINERGIC NEURONS CO-EXPRESS Î±-SYNUCLEIN AND TAU IN PROGRESSIVE SUPRANUCLEAR PALSY MarÃa Elena eErro Aguirre Full Text Available Objective: To analyze the frequency and distribution of Î±-synuclein deposits in progressive supranuclear palsy (PSP.Methods: The brains of 25 cases of pathologically confirmed PSP were evaluated with immunohistochemistry for Î±-synuclein and tau. Multiple immunofluorescent stains were applied to analyze the expression of tau and Î±-synuclein aggregates in catecholaminergic neurons. Patientsâ€™ clinical symptoms were retrospectively recorded. Results: Deposits Î±-synuclein in the form of typical Lewy bodies (LBs were only found in two PSP cases (8% that fulfilled the clinical subtype of PSP known as Richardsonâ€™s syndrome (RS. LBs were present in the locus ceruleus, substantia nigra pars compacta, basal forebrain, amygdala and cingulated cortex in a distribution mimicking that of Parkinsonâ€™s disease. Triple-immunolabeling revealed co-expression of Î±-synuclein and tau proteins in some tyrosine hydroxilase-positive neurons of the locus ceruleus and substantia nigra pars compacta.Conclusions: There is no apparent clinical correlation between the presence of LBs in PSP. Tau protein co-aggregate with Î±-synuclein in catecholaminergic neurons of PSP brains suggesting a synergistic interaction between the two proteins. This is in keeping with the current view of neurodegenerative disorders as â€˜misfolded protein diseasesâ€™. Interactions between co-expressed Arabidopsis sucrose transporters in the split-ubiquitin system Lalonde Sylvie Full Text Available Abstract Background The Arabidopsis genome contains nine sucrose transporter paralogs falling into three clades: SUT1-like, SUT2 and SUT4. The carriers differ in their kinetic properties. Many transport proteins are known to exist as oligomers. The yeast-based split ubiquitin system can be used to analyze the ability of membrane proteins to interact. Results Promoter-GUS fusions were used to analyze the cellular expression of the three transporter genes in transgenic Arabidopsis plants. All three fusion genes are co-expressed in companion cells. Protein-protein interactions between Arabidopsis sucrose transporters were tested using the split ubiquitin system. Three paralogous sucrose transporters are capable of interacting as either homo- or heteromers. The interactions are specific, since a potassium channel and a glucose transporter did not show interaction with sucrose transporters. Also the biosynthetic and metabolizing enzymes, sucrose phosphate phosphatase and sucrose synthase, which were found to be at least in part bound to the plasma membrane, did not specifically interact with sucrose transporters. Conclusions The split-ubiquitin system provides a powerful tool to detect potential interactions between plant membrane proteins by heterologous expression in yeast, and can be used to screen for interactions with membrane proteins as baits. Like other membrane proteins, the Arabidopsis sucrose transporters are able to form oligomers. The biochemical approaches are required to confirm the in planta interaction. Co-expression and characterization of enterocin CRL35 and its mutant in Escherichia coli Rosetta MasÃas Emilse Full Text Available Even though many sequences and structures of bacteriocins from lactic acid bacteria have been fully characterized so far, little information is currently available about bacteriocins heterologously produced by Escherichia coli. For this purpose, the structural gene of enterocin CRL35, munA, was PCR-amplified using specific primers and cloned downstream of PelB sequence in the pET22b (+ expression vector. E. coli Rosetta (DE3 pLysS was chosen as the host for production and enterocin was purified by an easy two-step protocol. The bacteriocin was correctly expressed with the expected intramolecular disulfide bond. Nevertheless, it was found that a variant of the enterocin, differing by 12 Da from the native polypeptide, was co-expressed by E. coli Rosetta in comparable amount. Indeed, the mutant bacteriocin contained two amino acid substitutions that were characterized by matrix assisted laser desorption ionization-time of flight (MALDI-TOF and HPLCelectrospray (ESI-Q-TOF tandem mass spectrometry (MS/ MS sequencing. This is the first report regarding the production of mutants of pediocin-like bacteriocins in the E. coli expression system. Immunohistochemical Observation of Co-expression of E- and N-cadherins in Rat Organogenesis Sakamoto, Atsushi; Murata, Kazumoto; Suzuki, Hideto; Yatabe, Megumi; Kikuchi, Motoshi Cadherins are a family of transmembrane glycoproteins that mediate cell-to-cell adhesion. Isoforms, including E- and N-cadherin, have been identified and shown to regulate morphogenesis through homophilic binding. In the ontogeny, the expressions of E- and N-cadherin change spatiotemporally, and the changes in cadherin isoforms, called cadherin switching, impact the mechanical adhesion of cells. Furthermore, cadherin functions as a receptor that transfers information from outside to inside cells, and in terms of switching, it affects cell phenotypes. To observe the expression patterns of E- and N-cadherins during embryogenesis and to identify cells that transiently coexpress both cadherins, we employed a recently developed immunohistochemical double staining technique in rat fetuses. At embryonic day 9, embryonic ectodermal cells more dominantly expressed E-cadherin, while mesodermal cells more dominantly expressed N-cadherin. At embryonic day 10, the expression pattern of E-cadherin in the surface ectoderm and endoderm and that of N-cadherin in the neuroectoderm were established. After embryonic day 10, unique co-expression of E- and N-cadherin was observed in primordia, such as the bulbus cordis, otic pit, notochord, and Rathkeâ€™s pouch. In the present study, it was possible to visualize the expression patterns of E- and N-cadherin during early fetal development, which enabled us to morphologically clarify cadherin switching Protocol design and analysis for cooperative wireless networks Song, Wei; Jin, A-Long This book focuses on the design and analysis of protocols for cooperative wireless networks, especially at the medium access control (MAC) layer and for crosslayer design between the MAC layer and the physical layer. It highlights two main points that are often neglected in other books: energy-efficiency and spatial random distribution of wireless devices. Effective methods in stochastic geometry for the design and analysis of wireless networks are also explored. After providing a comprehensive review of existing studies in the literature, the authors point out the challenges that are worth further investigation. Then, they introduce several novel solutions for cooperative wireless network protocols that reduce energy consumption and address spatial random distribution of wireless nodes. For each solution, the book offers a clear system model and problem formulation, details of the proposed cooperative schemes, comprehensive performance analysis, and extensive numerical and simulation results that validate th... Vibration analysis in nuclear power plant using neural networks Loskiewicz-Buczak, A.; Alguindigue, I.E. Vibration monitoring of components in nuclear power plants has been used for a number of years. This technique involves the analysis of vibration data coming from vital components of the plant to detect features which reflect the operational state of machinery. The analysis leads to the identification of potential failures and their causes, and makes it possible to perform efficient preventive maintenance. This paper documents the authors' work on the design of a vibration monitoring methodology enhanced by neural network technology. This technology provides an attractive complement to traditional vibration analysis because of the potential of neural networks to handle data which may be distorted or noisy. This paper describes three neural networks-based methods for the automation of some of the activities related to motion and vibration monitoring in engineering systems Emulation Platform for Cyber Analysis of Wireless Communication Network Protocols Van Leeuwen, Brian P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Eldridge, John M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States) Wireless networking and mobile communications is increasing around the world and in all sectors of our lives. With increasing use, the density and complexity of the systems increase with more base stations and advanced protocols to enable higher data throughputs. The security of data transported over wireless networks must also evolve with the advances in technologies enabling more capable wireless networks. However, means for analysis of the effectiveness of security approaches and implementations used on wireless networks are lacking. More specifically a capability to analyze the lower-layer protocols (i.e., Link and Physical layers) is a major challenge. An analysis approach that incorporates protocol implementations without the need for RF emissions is necessary. In this research paper several emulation tools and custom extensions that enable an analysis platform to perform cyber security analysis of lower layer wireless networks is presented. A use case of a published exploit in the 802.11 (i.e., WiFi) protocol family is provided to demonstrate the effectiveness of the described emulation platform. A network analysis of the Chinese stock market Huang, Wei-Qiang; Zhuang, Xin-Tian; Yao, Shuang In many practical important cases, a massive dataset can be represented as a very large network with certain attributes associated with its vertices and edges. Stock markets generate huge amounts of data, which can be use for constructing the network reflecting the marketâ€™s behavior. In this paper, we use a threshold method to construct Chinaâ€™s stock correlation network and then study the networkâ€™s structural properties and topological stability. We conduct a statistical analysis of this network and show that it follows a power-law model. We also detect components, cliques and independent sets in this network. These analyses allows one to apply a new data mining technique of classifying financial instruments based on stock price data, which provides a deeper insight into the internal structure of the stock market. Moreover, we test the topological stability of this network and find that it displays a topological robustness against random vertex failures, but it is also fragile to intentional attacks. Such a network stability property would be also useful for portfolio investment and risk management. Full Text Available Internet studies are carried out by various scientific disciplines and in different research perspectives. Sociological studies of the Internet deal with a new technology, a revolutionary means of mass communication and a social space. There is a set of research difficulties associated with the Internet. Firstly, the high speed and wide spread of Internet technologiesâ€™ development. Secondly, the collection and filtration of materials concerning with Internet studies. Lastly, the development of new conceptual categories, which are able to reflect the impact of the Internet development in contemporary world. In that regard the question of the â€œnetworkâ€� category use is essential. Network is the base of Internet functioning, on the one hand. On the other hand, network is the ground for almost all social interactions in modern society. So such society is called network society. Three theoretical network approaches in the Internet research case are the most relevant: network society theory, social network analysis and actor-network theory. Each of these theoretical approaches contributes to the study of the Internet. They shape various images of interactions between human beings in their entity and dynamics. All these approaches also provide information about the nature of these interactions.Â Social Network Analysis Identifies Key Participants in Conservation Development. Farr, Cooper M; Reed, Sarah E; Pejchar, Liba Understanding patterns of participation in private lands conservation, which is often implemented voluntarily by individual citizens and private organizations, could improve its effectiveness at combating biodiversity loss. We used social network analysis (SNA) to examine participation in conservation development (CD), a private land conservation strategy that clusters houses in a small portion of a property while preserving the remaining land as protected open space. Using data from public records for six counties in Colorado, USA, we compared CD participation patterns among counties and identified actors that most often work with others to implement CDs. We found that social network characteristics differed among counties. The network density, or proportion of connections in the network, varied from fewer than 2 to nearly 15%, and was higher in counties with smaller populations and fewer CDs. Centralization, or the degree to which connections are held disproportionately by a few key actors, was not correlated strongly with any county characteristics. Network characteristics were not correlated with the prevalence of wildlife-friendly design features in CDs. The most highly connected actors were biological and geological consultants, surveyors, and engineers. Our work demonstrates a new application of SNA to land-use planning, in which CD network patterns are examined and key actors are identified. For better conservation outcomes of CD, we recommend using network patterns to guide strategies for outreach and information dissemination, and engaging with highly connected actor types to encourage widespread adoption of best practices for CD design and stewardship. Hyperconnectivity in juvenile myoclonic epilepsy: a network analysis. Caeyenberghs, K; Powell, H W R; Thomas, R H; Brindley, L; Church, C; Evans, J; Muthukumaraswamy, S D; Jones, D K; Hamandi, K Juvenile myoclonic epilepsy (JME) is a common idiopathic (genetic) generalized epilepsy (IGE) syndrome characterized by impairments in executive and cognitive control, affecting independent living and psychosocial functioning. There is a growing consensus that JME is associated with abnormal function of diffuse brain networks, typically affecting frontal and fronto-thalamic areas. Using diffusion MRI and a graph theoretical analysis, we examined bivariate (network-based statistic) and multivariate (global and local) properties of structural brain networks in patients with JME (NÂ =Â 34) and matched controls. Neuropsychological assessment was performed in a subgroup of 14 patients. Neuropsychometry revealed impaired visual memory and naming in JME patients despite a normal full scale IQ (meanÂ =Â 98.6). Both JME patients and controls exhibited a small world topology in their white matter networks, with no significant differences in the global multivariate network properties between the groups. The network-based statistic approach identified one subnetwork of hyperconnectivity in the JME group, involving primary motor, parietal and subcortical regions. Finally, there was a significant positive correlation in structural connectivity with cognitive task performance. Our findings suggest that structural changes in JME patients are distributed at a network level, beyond the frontal lobes. The identified subnetwork includes key structures in spike wave generation, along with primary motor areas, which may contribute to myoclonic jerks. We conclude that analyzing the affected subnetworks may provide new insights into understanding seizure generation, as well as the cognitive deficits observed in JME patients. In vivo modification of tyrosine residues in recombinant mussel adhesive protein by tyrosinase co-expression in Escherichia coli Choi Yoo Full Text Available Abstract Background In nature, mussel adhesive proteins (MAPs show remarkable adhesive properties, biocompatibility, and biodegradability. Thus, they have been considered promising adhesive biomaterials for various biomedical and industrial applications. However, limited production of natural MAPs has hampered their practical applications. Recombinant production in bacterial cells could be one alternative to obtain useable amounts of MAPs, although additional post-translational modification of tyrosine residues into 3,4-dihydroxyphenyl-alanine (Dopa and Dopaquinone is required. The superior properties of MAPs are mainly attributed to the introduction of quinone-derived intermolecular cross-links. To solve this problem, we utilized a co-expression strategy of recombinant MAP and tyrosinase in Escherichia coli to successfully modify tyrosine residues in vivo. Results A recombinant hybrid MAP, fp-151, was used as a target for in vivo modification, and a dual vector system of pET and pACYC-Duet provided co-expression of fp-151 and tyrosinase. As a result, fp-151 was over-expressed and mainly obtained from the soluble fraction in the co-expression system. Without tyrosinase co-expression, fp-151 was over-expressed in an insoluble form in inclusion bodies. The modification of tyrosine residues in the soluble-expressed fp-151 was clearly observed from nitroblue tetrazolium staining and liquid-chromatography-mass/mass spectrometry analyses. The purified, in vivo modified, fp-151 from the co-expression system showed approximately 4-fold higher bulk-scale adhesive strength compared to in vitro tyrosinase-treated fp-151. Conclusion Here, we reported a co-expression system to obtain in vivo modified MAP; additional in vitro tyrosinase modification was not needed to obtain adhesive properties and the in vivo modified MAP showed superior adhesive strength compared to in vitro modified protein. It is expected that this co-expression strategy will accelerate Performance analysis for gait in camera networks Michela Goffredo; Imed Bouchrika; John Carter; Mark Nixon This paper deploys gait analysis for subject identification in multi-camera surveillance scenarios. We present a new method for viewpoint independent markerless gait analysis that does not require camera calibration and works with a wide range of directions of walking. These properties make the proposed method particularly suitable for gait identification in real surveillance scenarios where people and their behaviour need to be tracked across a set of cameras. Tests on 300 synthetic and real... The Reconstruction and Analysis of Gene Regulatory Networks. Zheng, Guangyong; Huang, Tao In post-genomic era, an important task is to explore the function of individual biological molecules (i.e., gene, noncoding RNA, protein, metabolite) and their organization in living cells. For this end, gene regulatory networks (GRNs) are constructed to show relationship between biological molecules, in which the vertices of network denote biological molecules and the edges of network present connection between nodes (Strogatz, Nature 410:268-276, 2001; Bray, Science 301:1864-1865, 2003). Biologists can understand not only the function of biological molecules but also the organization of components of living cells through interpreting the GRNs, since a gene regulatory network is a comprehensively physiological map of living cells and reflects influence of genetic and epigenetic factors (Strogatz, Nature 410:268-276, 2001; Bray, Science 301:1864-1865, 2003). In this paper, we will review the inference methods of GRN reconstruction and analysis approaches of network structure. As a powerful tool for studying complex diseases and biological processes, the applications of the network method in pathway analysis and disease gene identification will be introduced. Simulated, Emulated, and Physical Investigative Analysis (SEPIA) of networked systems. Burton, David P.; Van Leeuwen, Brian P.; McDonald, Michael James; Onunkwo, Uzoma A.; Tarman, Thomas David; Urias, Vincent E. This report describes recent progress made in developing and utilizing hybrid Simulated, Emulated, and Physical Investigative Analysis (SEPIA) environments. Many organizations require advanced tools to analyze their information system's security, reliability, and resilience against cyber attack. Today's security analysis utilize real systems such as computers, network routers and other network equipment, computer emulations (e.g., virtual machines) and simulation models separately to analyze interplay between threats and safeguards. In contrast, this work developed new methods to combine these three approaches to provide integrated hybrid SEPIA environments. Our SEPIA environments enable an analyst to rapidly configure hybrid environments to pass network traffic and perform, from the outside, like real networks. This provides higher fidelity representations of key network nodes while still leveraging the scalability and cost advantages of simulation tools. The result is to rapidly produce large yet relatively low-cost multi-fidelity SEPIA networks of computers and routers that let analysts quickly investigate threats and test protection approaches. Hybrid modeling and empirical analysis of automobile supply chain network Sun, Jun-yan; Tang, Jian-ming; Fu, Wei-ping; Wu, Bing-ying Based on the connection mechanism of nodes which automatically select upstream and downstream agents, a simulation model for dynamic evolutionary process of consumer-driven automobile supply chain is established by integrating ABM and discrete modeling in the GIS-based map. Firstly, the rationality is proved by analyzing the consistency of sales and changes in various agent parameters between the simulation model and a real automobile supply chain. Second, through complex network theory, hierarchical structures of the model and relationships of networks at different levels are analyzed to calculate various characteristic parameters such as mean distance, mean clustering coefficients, and degree distributions. By doing so, it verifies that the model is a typical scale-free network and small-world network. Finally, the motion law of this model is analyzed from the perspective of complex self-adaptive systems. The chaotic state of the simulation system is verified, which suggests that this system has typical nonlinear characteristics. This model not only macroscopically illustrates the dynamic evolution of complex networks of automobile supply chain but also microcosmically reflects the business process of each agent. Moreover, the model construction and simulation of the system by means of combining CAS theory and complex networks supplies a novel method for supply chain analysis, as well as theory bases and experience for supply chain analysis of auto companies. SEDIMENT ANALYSIS NETWORK FOR DECISION SUPPORT (SANDS) LANDSAT GEOLOGICAL SURVEY OF AL (GSA) ANALYSIS V1 Data.gov (United States) National Aeronautics and Space Administration â€” The Sediment Analysis Network for Decision Support (SANDS) Landsat Geological Survey of AL (GSA) Analysis dataset analyzed changes in the coastal shoreline and... UGV: security analysis of subsystem control network Abbott-McCune, Sam; Kobezak, Philip; Tront, Joseph; Marchany, Randy; Wicks, Al Unmanned Ground vehicles (UGVs) are becoming prolific in the heterogeneous superset of robotic platforms. The sensors which provide odometry, localization, perception, and vehicle diagnostics are fused to give the robotic platform a sense of the environment it is traversing. The automotive industry CAN bus has dominated the industry due to the fault tolerance and the message structure allowing high priority messages to reach the desired node in a real time environment. UGVs are being researched and produced at an accelerated rate to preform arduous, repetitive, and dangerous missions that are associated with a military action in a protracted conflict. The technology and applications of the research will inevitably be turned into dual-use platforms to aid civil agencies in the performance of their various operations. Our motivation is security of the holistic system; however as subsystems are outsourced in the design, the overall security of the system may be diminished. We will focus on the CAN bus topology and the vulnerabilities introduced in UGVs and recognizable security vulnerabilities that are inherent in the communications architecture. We will show how data can be extracted from an add-on CAN bus that can be customized to monitor subsystems. The information can be altered or spoofed to force the vehicle to exhibit unwanted actions or render the UGV unusable for the designed mission. The military relies heavily on technology to maintain information dominance, and the security of the information introduced onto the network by UGVs must be safeguarded from vulnerabilities that can be exploited. Collective Competence and Social Capital Analysis in Collaborative Networks Janaina Macke Full Text Available The present paper addresses the issue of collective competence and social capital analysis for collaborative networks. The objective of the project is to understand how collaborative networks can be influenced considering the perspective of social capital and core competences. In this model we defend the emphasis on endogenous resources, once the technology is, in a general way, accessible to most of the companies and, therefore will not be a long term competitive advantage. The model shows that collaborative networks will be more competitive and successful if they invest in to core elements that are: organizational culture and people. Therefore, the model contributes for the researches in socio-organizational filed and provides a tool to evaluate collaborative networks. An improved algorithm for connectivity analysis of distribution networks Kansal, M.L.; Devi, Sunita In the present paper, an efficient algorithm for connectivity analysis of moderately sized distribution networks has been suggested. Algorithm is based on generation of all possible minimal system cutsets. The algorithm is efficient as it identifies only the necessary and sufficient conditions of system failure conditions in n-out-of-n type of distribution networks. The proposed algorithm is demonstrated with the help of saturated and unsaturated distribution networks. The computational efficiency of the algorithm is justified by comparing the computational efforts with the previously suggested appended spanning tree (AST) algorithm. The proposed technique has the added advantage as it can be utilized for generation of system inequalities which is useful in reliability estimation of capacitated networks Stochastic sensitivity analysis and Langevin simulation for neural network learning Koda, Masato A comprehensive theoretical framework is proposed for the learning of a class of gradient-type neural networks with an additive Gaussian white noise process. The study is based on stochastic sensitivity analysis techniques, and formal expressions are obtained for stochastic learning laws in terms of functional derivative sensitivity coefficients. The present method, based on Langevin simulation techniques, uses only the internal states of the network and ubiquitous noise to compute the learning information inherent in the stochastic correlation between noise signals and the performance functional. In particular, the method does not require the solution of adjoint equations of the back-propagation type. Thus, the present algorithm has the potential for efficiently learning network weights with significantly fewer computations. Application to an unfolded multi-layered network is described, and the results are compared with those obtained by using a back-propagation method Center of attention: A network text analysis of American Sniper Starling Hunter Full Text Available Network Text Analysis (NTA is a term used to describe a variety of software - supported methods for modeling texts as networks of concepts. In this study we apply NTA to the screenplay of American Sniper, an Academy Award nominee for Best Adapted Screenplay in 2014. Specifically, we est ablish prior expectations as to the key themes associated with war films. We then empirically test whether words associated with the most influentially - positioned nodes in the network signify themes common to the war - film genre. As predicted, we find tha t words and concepts associated with the least constrained nodes in the text network were significantly more likely to be associated with the war genre and significantly less likely to be associated with genres to which the film did not belong. Performance analysis and improvement of WPAN MAC for home networks. Mehta, Saurabh; Kwak, Kyung Sup The wireless personal area network (WPAN) is an emerging wireless technology for future short range indoor and outdoor communication applications. The IEEE 802.15.3 medium access control (MAC) is proposed to coordinate the access to the wireless medium among the competing devices, especially for short range and high data rate applications in home networks. In this paper we use analytical modeling to study the performance analysis of WPAN (IEEE 802.15.3) MAC in terms of throughput, efficient bandwidth utilization, and delay with various ACK policies under error channel condition. This allows us to introduce a K-Dly-ACK-AGG policy, payload size adjustment mechanism, and Improved Backoff algorithm to improve the performance of the WPAN MAC. Performance evaluation results demonstrate the impact of our improvements on network capacity. Moreover, these results can be very useful to WPAN application designers and protocol architects to easily and correctly implement WPAN for home networking. Performance Analysis and Improvement of WPAN MAC for Home Networks Saurabh Mehta Full Text Available The wireless personal area network (WPAN is an emerging wireless technology for future short range indoor and outdoor communication applications. The IEEE 802.15.3 medium access control (MAC is proposed to coordinate the access to the wireless medium among the competing devices, especially for short range and high data rate applications in home networks. In this paper we use analytical modeling to study the performance analysis of WPAN (IEEE 802.15.3 MAC in terms of throughput, efficient bandwidth utilization, and delay with various ACK policies under error channel condition. This allows us to introduce a K-Dly-ACK-AGG policy, payload size adjustment mechanism, and Improved Backoff algorithm to improve the performance of the WPAN MAC. Performance evaluation results demonstrate the impact of our improvements on network capacity. Moreover, these results can be very useful to WPAN application designers and protocol architects to easily and correctly implement WPAN for home networking. Heterogeneous Deployment Analysis for Cost-Effective Mobile Network Evolution Coletti, Claudio network coverage and boosting network capacity in traffic hot-spot areas. The thesis deals with the deployment of both outdoor small cells and indoor femto cells. Amongst the outdoor solution, particular emphasis is put on relay base stations as backhaul costs can be reduced by utilizing LTE spectrum...... statistical models of deployment areas, the performance analysis is carried out in the form of operator case studies for large-scale deployment scenarios, including realistic macro network layouts and inhomogeneous spatial traffic distributions. Deployment of small cells is performed by means of proposed...... heuristic deployment algorithms, which combine network coverage and spatial user density information. As a secondary aspect, deployment solutions achieving the same coverage performance are compared in terms of Total Cost of Ownership (TCO), in order to investigate the viability of different deployment... Brain Network Analysis from High-Resolution EEG Signals de Vico Fallani, Fabrizio; Babiloni, Fabio lattice and a random structure. Such a model has been designated as "small-world" network in analogy with the concept of the small-world phenomenon observed more than 30 years ago in social systems. In a similar way, many types of functional brain networks have been analyzed according to this mathematical approach. In particular, several studies based on different imaging techniques (fMRI, MEG and EEG) have found that the estimated functional networks showed small-world characteristics. In the functional brain connectivity context, these properties have been demonstrated to reflect an optimal architecture for the information processing and propagation among the involved cerebral structures. However, the performance of cognitive and motor tasks as well as the presence of neural diseases has been demonstrated to affect such a small-world topology, as revealed by the significant changes of L and C. Moreover, some functional brain networks have been mostly found to be very unlike the random graphs in their degree-distribution, which gives information about the allocation of the functional links within the connectivity pattern. It was demonstrated that the degree distributions of these networks follow a power-law trend. For this reason those networks are called "scale-free". They still exhibit the small-world phenomenon but tend to contain few nodes that act as highly connected "hubs". Scale-free networks are known to show resistance to failure, facility of synchronization and fast signal processing. Hence, it would be important to see whether the scaling properties of the functional brain networks are altered under various pathologies or experimental tasks. The present Chapter proposes a theoretical graph approach in order to evaluate the functional connectivity patterns obtained from high-resolution EEG signals. In this way, the "Brain Network Analysis" (in analogy with the Social Network Analysis that has emerged as a key technique in modern sociology) represents an Multiscale analysis of spreading in a large communication network KivelÃ¤, Mikko; Pan, Raj Kumar; Kaski, Kimmo; KertÃ©sz, JÃ¡nos; SaramÃ¤ki, Jari; Karsai, MÃ¡rton In temporal networks, both the topology of the underlying network and the timings of interaction events can be crucial in determining how a dynamic process mediated by the network unfolds. We have explored the limiting case of the speed of spreading in the SI model, set up such that an event between an infectious and a susceptible individual always transmits the infection. The speed of this process sets an upper bound for the speed of any dynamic process that is mediated through the interaction events of the network. With the help of temporal networks derived from large-scale time-stamped data on mobile phone calls, we extend earlier results that indicate the slowing-down effects of burstiness and temporal inhomogeneities. In such networks, links are not permanently active, but dynamic processes are mediated by recurrent events taking place on the links at specific points in time. We perform a multiscale analysis and pinpoint the importance of the timings of event sequences on individual links, their correlations with neighboring sequences, and the temporal pathways taken by the network-scale spreading process. This is achieved by studying empirically and analytically different characteristic relay times of links, relevant to the respective scales, and a set of temporal reference models that allow for removing selected time-domain correlations one by one. Our analysis shows that for the spreading velocity, time-domain inhomogeneities are as important as the network topology, which indicates the need to take time-domain information into account when studying spreading dynamics. In particular, results for the different characteristic relay times underline the importance of the burstiness of individual links Reconstruction, visualization and explorative analysis of human pluripotency network Priyanka Narad Full Text Available Identification of genes/proteins involved in pluripotency and their inter-relationships is important for understanding the induction/loss and maintenance of pluripotency. With the availability of large volume of data on interaction/regulation of pluripotency scattered across a large number of biological databases and hundreds of scientific journals, it is required a systematic integration of data which will create a complete view of pluripotency network. Describing and interpreting such a network of interaction and regulation (i.e., stimulation and inhibition links are essential tasks of computational biology, an important first step in systems-level understanding of the underlying mechanisms of pluripotency. To address this, we have assembled a network of 166 molecular interactions, stimulations and inhibitions, based on a collection of research data from 147 publications, involving 122 human genes/proteins, all in a standard electronic format, enabling analyses by readily available software such as Cytoscape and its Apps (formerly called "Plugins". The network includes the core circuit of OCT4 (POU5F1, SOX2 and NANOG, its periphery (such as STAT3, KLF4, UTF1, ZIC3, and c-MYC, connections to upstream signaling pathways (such as ACTIVIN, WNT, FGF, and BMP, and epigenetic regulators (such as L1TD1, LSD1 and PRC2. We describe the general properties of the network and compare it with other literature-based networks. Gene Ontology (GO analysis is being performed to find out the over-represented GO terms in the network. We use several expression datasets to condense the network to a set of network links that identify the key players (genes/proteins and the pathways involved in transition from one state of pluripotency to other state (i.e., native to primed state, primed to non-pluripotent state and pluripotent to non-pluripotent state. Semantic network analysis of vaccine sentiment in online social media. Kang, Gloria J; Ewing-Nelson, Sinclair R; Mackey, Lauren; Schlitt, James T; Marathe, Achla; Abbas, Kaja M; Swarup, Samarth To examine current vaccine sentiment on social media by constructing and analyzing semantic networks of vaccine information from highly shared websites of Twitter users in the United States; and to assist public health communication of vaccines. Vaccine hesitancy continues to contribute to suboptimal vaccination coverage in the United States, posing significant risk of disease outbreaks, yet remains poorly understood. We constructed semantic networks of vaccine information from internet articles shared by Twitter users in the United States. We analyzed resulting network topology, compared semantic differences, and identified the most salient concepts within networks expressing positive, negative, and neutral vaccine sentiment. The semantic network of positive vaccine sentiment demonstrated greater cohesiveness in discourse compared to the larger, less-connected network of negative vaccine sentiment. The positive sentiment network centered around parents and focused on communicating health risks and benefits, highlighting medical concepts such as measles, autism, HPV vaccine, vaccine-autism link, meningococcal disease, and MMR vaccine. In contrast, the negative network centered around children and focused on organizational bodies such as CDC, vaccine industry, doctors, mainstream media, pharmaceutical companies, and United States. The prevalence of negative vaccine sentiment was demonstrated through diverse messaging, framed around skepticism and distrust of government organizations that communicate scientific evidence supporting positive vaccine benefits. Semantic network analysis of vaccine sentiment in online social media can enhance understanding of the scope and variability of current attitudes and beliefs toward vaccines. Our study synthesizes quantitative and qualitative evidence from an interdisciplinary approach to better understand complex drivers of vaccine hesitancy for public health communication, to improve vaccine confidence and vaccination coverage Network application of PIXE trace element analysis Niizeki, T.; Kawasaki, K.; Hattori, T. Particle Induced X-ray Emission (PIXE) is a very sensitive analytical technique for determinations of trace elements. But the number of users is limited because there are not so much accelerators which can be used easily. On the other hand, PIXE is a typical machine analysis which can easily analyze automatically and make online data acquisition system. If there is useful online data handling system then PIXE analysis should be more useful for many persons. Therefore we develop to online PIXE facility at Tokyo Institute of Technology VdG laboratory and use it for environmental educations. (author) Predictive networks: a flexible, open source, web application for integration and analysis of human gene networks. Haibe-Kains, Benjamin; Olsen, Catharina; Djebbari, Amira; Bontempi, Gianluca; Correll, Mick; Bouton, Christopher; Quackenbush, John Genomics provided us with an unprecedented quantity of data on the genes that are activated or repressed in a wide range of phenotypes. We have increasingly come to recognize that defining the networks and pathways underlying these phenotypes requires both the integration of multiple data types and the development of advanced computational methods to infer relationships between the genes and to estimate the predictive power of the networks through which they interact. To address these issues we have developed Predictive Networks (PN), a flexible, open-source, web-based application and data services framework that enables the integration, navigation, visualization and analysis of gene interaction networks. The primary goal of PN is to allow biomedical researchers to evaluate experimentally derived gene lists in the context of large-scale gene interaction networks. The PN analytical pipeline involves two key steps. The first is the collection of a comprehensive set of known gene interactions derived from a variety of publicly available sources. The second is to use these 'known' interactions together with gene expression data to infer robust gene networks. The PN web application is accessible from http://predictivenetworks.org. The PN code base is freely available at https://sourceforge.net/projects/predictivenets/. Reachability Analysis in Probabilistic Biological Networks. Gabr, Haitham; Todor, Andrei; Dobra, Alin; Kahveci, Tamer Extra-cellular molecules trigger a response inside the cell by initiating a signal at special membrane receptors (i.e., sources), which is then transmitted to reporters (i.e., targets) through various chains of interactions among proteins. Understanding whether such a signal can reach from membrane receptors to reporters is essential in studying the cell response to extra-cellular events. This problem is drastically complicated due to the unreliability of the interaction data. In this paper, we develop a novel method, called PReach (Probabilistic Reachability), that precisely computes the probability that a signal can reach from a given collection of receptors to a given collection of reporters when the underlying signaling network is uncertain. This is a very difficult computational problem with no known polynomial-time solution. PReach represents each uncertain interaction as a bi-variate polynomial. It transforms the reachability problem to a polynomial multiplication problem. We introduce novel polynomial collapsing operators that associate polynomial terms with possible paths between sources and targets as well as the cuts that separate sources from targets. These operators significantly shrink the number of polynomial terms and thus the running time. PReach has much better time complexity than the recent solutions for this problem. Our experimental results on real data sets demonstrate that this improvement leads to orders of magnitude of reduction in the running time over the most recent methods. Availability: All the data sets used, the software implemented and the alignments found in this paper are available at http://bioinformatics.cise.ufl.edu/PReach/. Bayesian networks for omics data analysis Gavai, A.K. This thesis focuses on two aspects of high throughput technologies, i.e. data storage and data analysis, in particular in transcriptomics and metabolomics. Both technologies are part of a research field that is generally called â€˜omicsâ€™ (or â€˜-omicsâ€™, with a leading hyphen), which refers to genomics, Neural network analysis in pharmacogenetics of mood disorders Serretti Alessandro Full Text Available Abstract Background The increasing number of available genotypes for genetic studies in humans requires more advanced techniques of analysis. We previously reported significant univariate associations between gene polymorphisms and antidepressant response in mood disorders. However the combined analysis of multiple gene polymorphisms and clinical variables requires the use of non linear methods. Methods In the present study we tested a neural network strategy for a combined analysis of two gene polymorphisms. A Multi Layer Perceptron model showed the best performance and was therefore selected over the other networks. One hundred and twenty one depressed inpatients treated with fluvoxamine in the context of previously reported pharmacogenetic studies were included. The polymorphism in the transcriptional control region upstream of the 5HTT coding sequence (SERTPR and in the Tryptophan Hydroxylase (TPH gene were analysed simultaneously. Results A multi layer perceptron network composed by 1 hidden layer with 7 nodes was chosen. 77.5 % of responders and 51.2% of non responders were correctly classified (ROC area = 0.731 â€“ empirical p value = 0.0082. Finally, we performed a comparison with traditional techniques. A discriminant function analysis correctly classified 34.1 % of responders and 68.1 % of non responders (F = 8.16 p = 0.0005. Conclusions Overall, our findings suggest that neural networks may be a valid technique for the analysis of gene polymorphisms in pharmacogenetic studies. The complex interactions modelled through NN may be eventually applied at the clinical level for the individualized therapy. s-core network decomposition: A generalization of k-core analysis to weighted networks Eidsaa, Marius; Almaas, Eivind A broad range of systems spanning biology, technology, and social phenomena may be represented and analyzed as complex networks. Recent studies of such networks using k-core decomposition have uncovered groups of nodes that play important roles. Here, we present s-core analysis, a generalization of k-core (or k-shell) analysis to complex networks where the links have different strengths or weights. We demonstrate the s-core decomposition approach on two random networks (ER and configuration model with scale-free degree distribution) where the link weights are (i) random, (ii) correlated, and (iii) anticorrelated with the node degrees. Finally, we apply the s-core decomposition approach to the protein-interaction network of the yeast Saccharomyces cerevisiae in the context of two gene-expression experiments: oxidative stress in response to cumene hydroperoxide (CHP), and fermentation stress response (FSR). We find that the innermost s-cores are (i) different from innermost k-cores, (ii) different for the two stress conditions CHP and FSR, and (iii) enriched with proteins whose biological functions give insight into how yeast manages these specific stresses. This research concentrates on the design and analysis of an algorithm referred to as Virtual Network Configuration (VNC) which uses predicted future states of a system for faster network configuration and management. VNC is applied to the configuration of a wireless mobile ATM network. VNC is built on techniques from parallel discrete event simulation merged with constraints from real-time systems and applied to mobile ATM configuration and handoff. Configuration in a mobile network is a dynamic and continuous process. Factors such as load, distance, capacity and topology are all constantly changing in a mobile environment. The VNC algorithm anticipates configuration changes and speeds the reconfiguration process by pre-computing and caching results. VNC propagates local prediction results throughout the VNC enhanced system. The Global Positioning System is an enabling technology for the use of VNC in mobile networks because it provides location information and accurate time for each node. This research has resulted in well defined structures for the encapsulation of physical processes within Logical Processes and a generic library for enhancing a system with VNC. Enhancing an existing system with VNC is straight forward assuming the existing physical processes do not have side effects. The benefit of prediction is gained at the cost of additional traffic and processing. This research includes an analysis of VNC and suggestions for optimization of the VNC algorithm and its parameters. A statistical framework for differential network analysis from microarray data Datta Somnath Full Text Available Abstract Background It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of genes are dependent on each other. Experimental techniques to detect such interacting pairs of genes have been in place for quite some time. With the advent of microarray technology, newer computational techniques to detect such interaction or association between gene expressions are being proposed which lead to an association network. While most microarray analyses look for genes that are differentially expressed, it is of potentially greater significance to identify how entire association network structures change between two or more biological settings, say normal versus diseased cell types. Results We provide a recipe for conducting a differential analysis of networks constructed from microarray data under two experimental settings. At the core of our approach lies a connectivity score that represents the strength of genetic association or interaction between two genes. We use this score to propose formal statistical tests for each of following queries: (i whether the overall modular structures of the two networks are different, (ii whether the connectivity of a particular set of "interesting genes" has changed between the two networks, and (iii whether the connectivity of a given single gene has changed between the two networks. A number of examples of this score is provided. We carried out our method on two types of simulated data: Gaussian networks and networks based on differential equations. We show that, for appropriate choices of the connectivity scores and tuning parameters, our method works well on simulated data. We also analyze a real data set involving normal versus heavy mice and identify an interesting set of genes that may play key roles in obesity. Conclusions Examining changes in network structure can provide valuable information about the Network analysis reveals stage-specific changes in zebrafish embryo development using time course whole transcriptome profiling and prior biological knowledge. Zhang, Yuji biological processes enriched in co-expressed genes under different conditions. The enriched biological processes include translation elongation, nucleosome assembly, and retina development. These network dynamics provide new insights into the impact of 1Î±, 25-Dihydroxyvitamin D3 treatment in bone and cartilage development. We developed a network-based approach to analyzing the DEGs at different time points by integrating molecular interactions and gene ontology information. These results demonstrate that the proposed approach can provide insight on the molecular mechanisms taking place in vertebrate embryo development upon treatment with 1Î±, 25(OH)2D3. Our approach enables the monitoring of biological processes that can serve as a basis for generating new testable hypotheses. Such network-based integration approach can be easily extended to any temporal- or condition-dependent genomic data analyses. Network analysis shining light on parasite ecology and diversity. Poulin, Robert The vast number of species making up natural communities, and the myriad interactions among them, pose great difficulties for the study of community structure, dynamics and stability. Borrowed from other fields, network analysis is making great inroads in community ecology and is only now being applied to host-parasite interactions. It allows a complex system to be examined in its entirety, as opposed to one or a few components at a time. This review explores what network analysis is and how it can be used to investigate parasite ecology. It also summarizes the first findings to emerge from network analyses of host-parasite interactions and identifies promising future directions made possible by this approach. Copyright Â© 2010 Elsevier Ltd. All rights reserved. Analysis of the atmospheric 7Be radioactivity by neural network Moroz, Z.; Myslek-Laurikainen, B.; Matul, M.; Mikolajewski, S.; Preibisz, Z.; Trzaskowaka, H.; Kownacki, C. Computational methods of artificial intelligence (neural networks) and modern signal processing (wavelet decomposition were applied for the analysis of atmospheric 7 Be radioactivity data. Measurements were performed each week during 1994-2001 in the sampling station placed at Swider Geophysical Observatory. Raw data as well as those averaged over 4 and 10 weeks were used. Ability of the neural networks for the purpose of representation, interpolation and prediction was tested. The corresponding relative errors are calculated. Next, the time sequences were decomposed using the wavelet method and eight components of different time scales were obtained. Neural networks were applied separately to each of those components. Application of such analysis and their possible extensions useful for the construction of phenomeno-logical models of atmospheric radioactivity are discussed. (author) Spontaneous brain network activity: Analysis of its temporal complexity Mangor Pedersen Full Text Available The brain operates in a complex way. The temporal complexity underlying macroscopic and spontaneous brain network activity is still to be understood. In this study, we explored the brainâ€™s complexity by combining functional connectivity, graph theory, and entropy analyses in 25 healthy people using task-free functional magnetic resonance imaging. We calculated the pairwise instantaneous phase synchrony between 8,192 brain nodes for a total of 200 time points. This resulted in graphs for which time series of clustering coefficients (the â€œcliquinessâ€� of a node and participation coefficients (the between-module connectivity of a node were estimated. For these two network metrics, sample entropy was calculated. The procedure produced a number of results: (1 Entropy is higher for the participation coefficient than for the clustering coefficient. (2 The average clustering coefficient is negatively related to its associated entropy, whereas the average participation coefficient is positively related to its associated entropy. (3 The level of entropy is network-specific to the participation coefficient, but not to the clustering coefficient. High entropy for the participation coefficient was observed in the default-mode, visual, and motor networks. These results were further validated using an independent replication dataset. Our work confirms that brain networks are temporally complex. Entropy is a good candidate metric to explore temporal network alterations in diseases with paroxysmal brain disruptions, including schizophrenia and epilepsy. In recent years, connectomics has provided significant insights into the topological complexity of brain networks. However, the temporal complexity of brain networks still remains somewhat poorly understood. In this study we used entropy analysis to demonstrate that the properties of network segregation (the clustering coefficient and integration (the participation coefficient are temporally complex Social Network Analysis Utilizing Big Data Technology Magnusson, Jonathan As of late there has been an immense increase of data within modern society. This is evident within the field of telecommunications. The amount of mobile data is growing fast. For a telecommunication operator, this provides means of getting more information of specific subscribers. The applications of this are many, such as segmentation for marketing purposes or detection of churners, people about to switching operator. Thus the analysis and information extraction is of great value. An approa... From systems biology to photosynthesis and whole-plant physiology: a conceptual model for integrating multi-scale networks. Weston, David J; Hanson, Paul J; Norby, Richard J; Tuskan, Gerald A; Wullschleger, Stan D Network analysis is now a common statistical tool for molecular biologists. Network algorithms are readily used to model gene, protein and metabolic correlations providing insight into pathways driving biological phenomenon. One output from such an analysis is a candidate gene list that can be responsible, in part, for the biological process of interest. The question remains, however, as to whether molecular network analysis can be used to inform process models at higher levels of biological organization. In our previous work, transcriptional networks derived from three plant species were constructed, interrogated for orthology and then correlated with photosynthetic inhibition at elevated temperature. One unique aspect of that study was the link from co-expression networks to net photosynthesis. In this addendum, we propose a conceptual model where traditional network analysis can be linked to whole-plant models thereby informing predictions on key processes such as photosynthesis, nutrient uptake and assimilation, and C partitioning. National Ignition Facility (NIF) Control Network Design and Analysis Bryant, R M; Carey, R W; Claybourn, R V; Pavel, G; Schaefer, W J The control network for the National Ignition Facility (NIF) is designed to meet the needs for common object request broker architecture (CORBA) inter-process communication, multicast video transport, device triggering, and general TCP/IP communication within the NIF facility. The network will interconnect approximately 650 systems, including the embedded controllers, front-end processors (FEPs), supervisory systems, and centralized servers involved in operation of the NIF. All systems are networked with Ethernet to serve the majority of communication needs, and asynchronous transfer mode (ATM) is used to transport multicast video and synchronization triggers. CORBA software infra-structure provides location-independent communication services over TCP/IP between the application processes in the 15 supervisory and 300 FEP systems. Video images sampled from 500 video cameras at a 10-Hz frame rate will be multicast using direct ATM Application Programming Interface (API) communication from video FEPs to any selected operator console. The Ethernet and ATM control networks are used to broadcast two types of device triggers for last-second functions in a large number of FEPs, thus eliminating the need for a separate infrastructure for these functions. Analysis, design, modeling, and testing of the NIF network has been performed to provide confidence that the network design will meet NIF control requirements Social network analysis in identifying influential webloggers: A preliminary study Hasmuni, Noraini; Sulaiman, Nor Intan Saniah; Zaibidi, Nerda Zura In recent years, second generation of internet-based services such as weblog has become an effective communication tool to publish information on the Web. Weblogs have unique characteristics that deserve users' attention. Some of webloggers have seen weblogs as appropriate medium to initiate and expand business. These webloggers or also known as direct profit-oriented webloggers (DPOWs) communicate and share knowledge with each other through social interaction. However, survivability is the main issue among DPOW. Frequent communication with influential webloggers is one of the way to keep survive as DPOW. This paper aims to understand the network structure and identify influential webloggers within the network. Proper understanding of the network structure can assist us in knowing how the information is exchanged among members and enhance survivability among DPOW. 30 DPOW were involved in this study. Degree centrality and betweenness centrality measurement in Social Network Analysis (SNA) were used to examine the strength relation and identify influential webloggers within the network. Thus, webloggers with the highest value of these measurements are considered as the most influential webloggers in the network. Analysis of the partnership network in the clean development mechanism Kang, Moon Jung; Park, Jihyoun The clean development mechanism (CDM) is a global collaborative action proposed at the Kyoto Protocol in response to climate change issues. The CDM contributes to cost-efficient reduction of greenhouse gas emissions in industrialized countries and promotes sustainable development in developing countries. Its fundamental framework is based on partnerships between industrialized and developing countries. This study employs social network analysis to investigate the dynamics of the partnership networks observed in 3816 CDM projects registered in the database of the United Nations Framework Convention on Climate Change over the period of 2005 to 2011. Our three main findings can be summarized as follows. First, the CDM partnership network is a small world; however, its density tends to decrease as the number of participants for a CDM project decreases. Second, the partnership networksâ€™ leading groups tend to shift from partner countries into host countries. Third, a host country that pursues more partnership-based projects takes better control of resources and knowledge-flow in the ego-network formed around that country, and can thus better utilize global resources for its CDM projects. - Highlights: â–º We investigate dynamics of the international partnership networks of CDM projects. â–º The density of CDM networks tends to decrease by time. â–º The partnership networksâ€™ leading groups tend to shift into host countries. â–º A host country with more partnerships better utilizes global knowledge resources. Utilization of Selected Data Mining Methods for Communication Network Analysis V. Ondryhal Full Text Available The aim of the project was to analyze the behavior of military communication networks based on work with real data collected continuously since 2005. With regard to the nature and amount of the data, data mining methods were selected for the purpose of analyses and experiments. The quality of real data is often insufficient for an immediate analysis. The article presents the data cleaning operations which have been carried out with the aim to improve the input data sample to obtain reliable models. Gradually, by means of properly chosen SW, network models were developed to verify generally valid patterns of network behavior as a bulk service. Furthermore, unlike the commercially available communication networks simulators, the models designed allowed us to capture nonstandard models of network behavior under an increased load, verify the correct sizing of the network to the increased load, and thus test its reliability. Finally, based on previous experience, the models enabled us to predict emergency situations with a reasonable accuracy. Use of neural networks in the analysis of complex systems The application of neural networks, alone or in conjunction with other advanced technologies (expert systems, fuzzy logic, and/or genetic algorithms) to some of the problems of complex engineering systems has the potential to enhance the safety reliability and operability of these systems. The work described here deals with complex systems or parts of such systems that can be isolated from the total system. Typically, the measured variables from the systems are analog variables that must be sampled and normalized to expected peak values before they are introduced into neural networks. Often data must be processed to put it into a form more acceptable to the neural network. The neural networks are usually simulated on modern high-speed computers that carry out the calculations serially. However, it is possible to implement neural networks using specially designed microchips where the network calculations are truly carried out in parallel, thereby providing virtually instantaneous outputs for each set of inputs. Specific applications described include: Diagnostics: State of the Plant; Hybrid System for Transient Identification; Detection of Change of Mode in Complex Systems; Sensor Validation; Plant-Wide Monitoring; Monitoring of Performance and Efficiency; and Analysis of Vibrations. Although the specific examples described deal with nuclear power plants or their subsystems, the techniques described can be applied to a wide variety of complex engineering systems Study of co-authorship network of papers in the Journal of Research in Medical Sciences using social network analysis Firoozeh Zare-Farashbandi Full Text Available Background: Co-authorship is one of the most tangible forms of research collaboration. A co-authorship network is a social network in which the authors through participation in one or more publication through an indirect path have linked to each other. The present research using the social network analysis studied co-authorship network of 681 articles published in Journal of Research in Medical Sciences (JRMS during 2008-2012. Materials and Methods: The study was carried out with the scientometrics approach and using co-authorship network analysis of authors. The topology of the co-authorship network of 681 published articles in JRMS between 2008 and 2012 was analyzed using macro-level metrics indicators of network analysis such as density, clustering coefficient, components and mean distance. In addition, in order to evaluate the performance of each authors and countries in the network, the micro-level indicators such as degree centrality, closeness centrality and betweenness centrality as well as productivity index were used. The UCINET and NetDraw softwares were used to draw and analyze the co-authorship network of the papers. Results: The assessment of the authors productivity in this journal showed that the first ranks were belonged to only five authors, respectively. Furthermore, analysis of the co-authorship of the authors in the network demonstrated that in the betweenness centrality index, three authors of them had the good position in the network. They can be considered as the network leaders able to control the flow of information in the network compared with the other members based on the shortest paths. On the other hand, the key role of the network according to the productivity and centrality indexes was belonged to Iran, Malaysia and United States of America. Conclusion: Co-authorship network of JRMS has the characteristics of a small world network. In addition, the theory of 6Â° separation is valid in this network was also true. Network Analysis with SiLK Carnegie Mellon University rwcut Default Display By default â€¢ sIP , sPort â€¢ dIP, dPort â€¢ protocol â€¢ packets, bytes â€¢ flags â€¢ sTime, eTime, duration...TCP/IP SOCKET IP address: 10.0.0.1 L4 protocol : TCP High-numbered ephemeral port # TCP/IP SOCKET IP address: 203.0.113.1 L4 protocol : TCP Low-numbered...Fields found to be useful in analysis: â€¢ source address, destination address â€¢ source port, destination port (Internet Control Message Protocol Understanding Groups in Outdoor Adventure Education through Social Network Analysis Jostad, Jeremy; Sibthorp, Jim; Paisley, Karen Relationships are a critical component to the experience of an outdoor adventure education (OAE) program, therefore, more fruitful ways of investigating groups is needed. Social network analysis (SNA) is an effective tool to study the relationship structure of small groups. This paper provides an explanation of SNA and shows how it was used by theâ€¦ Efficient health care service delivery using network analysis: a case ... critical path) and less important together with their time duration. The average total time spent in the hospital was 43 minutes but with effective capacity planning using network analysis the total time was reduced to 18 minutes and the critical pathÂ ... "Shorthaul" pulpwood transport in South Africa. A network analysis ... ... road conditions to the extent that highway type vehicles are unable to reach roadside landings. This necessitates the use of intermediate storage sites, from where timber is once again loaded and transported to its final destination. A network analysis model, assisted by newly developed and industry accepted terminology,Â ... Analysis of Degree 5 Chordal Rings for Network Topologies Riaz, M. Tahir; Pedersen, Jens Myrup; Bujnowski, SÅ‚awomir This paper presents an analysis of degree 5 chordal rings, from a network topology point of view. The chordal rings are mainly evaluated with respect to average distance and diameter. We derive approximation expressions for the related ideal graphs, and show that these matches the real chordal... Customer-oriented finite perturbation analysis for queueing networks Heidergott, B.F. We consider queueing networks for which the performance measureJ ( ) depends on a parameter , which can be a service time parameter or a buffer size, and we are interested in sensitivity analysis of J ( ) with respect to . We introduce a new method, called customer-oriented finite perturbation Improving Family Forest Knowledge Transfer through Social Network Analysis Gorczyca, Erika L.; Lyons, Patrick W.; Leahy, Jessica E.; Johnson, Teresa R.; Straub, Crista L. To better engage Maine's family forest landowners our study used social network analysis: a computational social science method for identifying stakeholders, evaluating models of engagement, and targeting areas for enhanced partnerships. Interviews with researchers associated with a research center were conducted to identify how social networkâ€¦ Algorithms for the Network Analysis of Bilateral Tax Treaties S.C. Polak (Sven) htmlabstractIn this thesis we conduct a network analysis of bilateral tax treaties. We are given tax data of 108 countries. Companies often send money from country to country via indirect routes, because then the tax that must be paid might be lower. In the thesis we will study the most important	cc/2021-04/en_middle_0086.json.gz/line1797164
__label__wiki	0.642051	0.642051	Wrestling Examiner Your best destination for all of the latest news, rumors and articles from the world of professional wrestling. CWFH’s Halston Boddy Interview- Halston Speaks on Managing Heather Monroe, Fighting with Nikko Marquez, and the Massive Brawl on 9/29/20 WWE SmackDown Review 8/7 – Likes & Dislikes The Rock Purchases The XFL, Official Press Release WWE SmackDown Review 7/31 – Likes & Dislikes Booker T On Rumors That Summerslam May Happen on a Beach With Fans Johnny Gargano On His Heel Turn, Working More Closely With Candice LeRae & Much More Scarlett Bordeaux Shares Swimsuit Photo on Instagram WWE Reportedly Still Planning to Stream Indie Wrestling Content On WWE Network AJ Styles On Summerslam Outdoor Venue Rumors Rusev Says He Is Done With Wrestling Reportedly, Remembers Last Conversation With Vince McMahon Home / WWE / Edge Says His Injury Was A Learning Experience Edge Says His Injury Was A Learning Experience Jai Michel July 12, 2020 WWE Leave a comment WWE Superstar recently did an interview with Sports Illustrated, where he talked about his triceps tear injury that he suffered while taping the match for the WWE Backlash PPV. He calls the injury a learning experience. He also talks about being nervous when he made his return to WWE at the Royal Rumble. Check out the highlights below. Edge on the injury he suffered at Backlash: “It’s OK. You know, I look at injuries and ask myself, ‘How was it compared to the Achilles tear?’ [laughs]. Compared to the Achilles tear, it was nothing. There was surgery, but I know the drill. I know what I have to do, and I know you have to baby it for the first month, then I can start putting the nose to the grindstone. I can still do exercises for the rest of my body, which is good, so it’s just being careful. It’s a learning experience, too. The doctor that did the surgery said that there was a good chance my tricep was already partially torn going into the match, so I look it as a learning experience. My elbow was sore for probably a month, but I thought it was one of those regular aches and pains. I have a bunch of floating chips in my elbow, so I told myself, ‘Of course it’s going to hurt.’ This is a reminder that I need to listen to those things. At 46 years old, my body is trying to tell me something’s up. Now I have that knowledge going forward if something’s aching.” Edge on if he knew his triceps was torn during the match: “I knew. I took an RKO, and I felt a little nauseous and I got a cold sweat—not a hot sweat. That’s generally when you know you’ve popped something. It wasn’t all that painful in comparison to my neck pain over the years or compared to tearing both pecs or tearing my Achilles. I just thought, ‘I might have torn it a little bit,’ and then I found out I tore it completely off the bone. I gauge everything to the pain of tearing my Achilles, so not a lot can compare.” Edge on making his return at the Royal Rumble: “I can truly say that was the first day in my wrestling career when I was nervous. Even before my first match way back in WWF in ’96, I wasn’t nervous. I felt ready, I was confident, I was young and indestructible. This was the first time that I’ve wrestled having had kids. I think that was the big thing for me. I’m coming back from this injury that was supposed to be impossible to come back from, so that was on the table. And I have kids at home now. There are a lot of responsibilities involved in this, so that was really nerve-wracking, and that was foreign to me. I wasn’t used to feeling nervous. Going back to Jay, that was the first time he’d seen me nervous. Beth [Phoenix, my wife,] and I weren’t together before when I wrestled, so she didn’t know what I was like. Jay knew I didn’t get nervous. So when I was nervous, that changed everything for him. Even the hiding and all that, the strangest thing for me was coming to grips with having nerves for the first time. I can’t say I really liked it, and I’ve had them for all three matches now. I better quickly come to grips with it [laughs].” Jai Michel Huge fan of pro-wrestling for over 25 years. Lived through the Monday night wars (WWE/WCW) and the ECW revolution. Currently a big fan of Lucha Underground, NXT, MLW, PWG, and even Impact Wrestling… Backlash Edge Randy Orton Royal Rumble WWE 2020-07-12 Tags Backlash Edge Randy Orton Royal Rumble WWE Previous Lana Gives Update On Her Parent’s Health After They Both Tested Positive for COVID-19 Next Rusev Confirms He’s Been Diagnosed With COVID-19 On the latest episode of The Hall of Fame Podcast, Booker T talked about the … WWE NXT Superstar Johnny Gargano recently did an interview with TV Insider where he discussed … Latest Exclusive Articles… Latest Exclusive Podcasts… WrestlingExaminer.com is not affiliated with World Wrestling Entertainment (WWE) , TNA Wrestling/Impact Wrestling or Lucha Underground in any form. In addition, we are not affiliated with any independent professional wrestling organization. All pictures and media files are copyrighted by their respective owners. WrestlingExaminer.com© Copyright 2016, All Rights Reserved Privacy Policy	cc/2021-04/en_middle_0086.json.gz/line1797166
__label__cc	0.712512	0.287488	Global airlines will end the year losing more than $100 billion Business Travel World Global airlines will end the year losing more than $100 billion this year, and it could even rise to as much as $118 billion, according to the latest forecasts from International Air Transport Association (IATA). That’s significantly higher than it had projected earlier. Prior to the second lockdown, IATA had projected loses for airlines at $84 billion but this new projection could be $34 billion higher. The hopes of the airline industry are significantly linked to the success of a vaccine. In the UK airlines have seen some optimism with the announcement that Air travellers can pay for a private Covid-19 test to half the 14-day quarantine. The industry body now expects airlines to lose another $38 billion in 2021, compared to its previous forecast of just $15 billion. Although a significantly reduced amount, it is still “much more than what the industry lost in the previous crises of 9/11 and the global financial crisis,” said Pearce. When will fliers return? Passenger numbers are expected to rise to 2.8 billion in 2021. That would be 1 billion more than in 2020, but still 1.7 billion travellers short of 2019’s. Cargo will continue to perform well, partly due to the role it will play in upcoming vaccine distribution. The International Airlines Travel Association IATA expects volumes to grow to 61.2 million tonnes next year, matching the 61.3 million tonnes in 2019. Qantas makes vaccine mandatory Qantas Airline has announced passengers will be banned from international flights unless they get the COVID-19 jab. Tens of thousands of conspiracy theorists encouraged their Facebook followers to vote on online polls to say they would abandon travel plans instead of being immunised. A Current Affair poll titled ‘will you take the vaccine to travel internationally?’ was taken over by responses from anti-vaxxer groups, with 88 per cent saying they wouldn’t fly overseas with the airline. The CEO of Qantas, Alan Joyce, He predicted the rule would become standard practice around the world as governments and airlines consider introducing electronic vaccination passports. Sewage testing on planes, monitoring ankle bracelets and DNA testing are also being considered to keep passengers safe. Tags Air Travel Airlines News Dubai featured Heathrow Airport IATA Manchester Airport Qantas Airline Travelling to Dubai Previous articleMosques in Dubai and Mosques in UAE to reopen on Friday Dec 4 Next articleElon Musk’s net worth rises to $127.9bn-The second-richest person Sunday Papers: Over-18’s vaccinated by June - ‘Quarantine hotels'	cc/2021-04/en_middle_0086.json.gz/line1797167
__label__cc	0.55593	0.44407	Newsletter signup Accessibility Dorchester Collection Moments The DorchesterLondon 45 Park LaneLondon Coworth ParkAscot Le MeuriceParis Hôtel Plaza AthénéeParis Hotel EdenRome Hotel Principe di SavoiaMilan The Beverly Hills HotelLos Angeles Hotel Bel-AirLos Angeles About Dorchester Collection Inside the Oscars’ Governors Ball with Wolfgang Puck Having created and hosted the post-Oscars party menu for the past 25 years, Wolfgang Puck is as excited as ever to be working his magic at this year’s event. Here he shares some of his highlights and reveals who he wants to win an Oscar. What’s the big deal about awards season? Los Angeles is so different to anywhere else in the world and during awards season the city really comes to life with an incredible buzz. The topic of conversation on everyone’s lips is who has won what and who will win next week. It also inspires me to try and watch all the nominated movies so I appreciate what all the fuss is about. What’s your favourite thing about the Governors Ball? I find it a real honour to keep being asked to cater for such a prestigious occasion and it’s something I always look forward. The party is a wonderful opportunity to see old friends from Hollywood and all around the world, many of which I’ve known for the past 40 years. When it comes to the menu, such a great occasion always challenges me to bring something new to the table. What’s your most memorable moment? Wow, there have been so many over the years but this one sticks out for me. One year I put chicken pot pie on the menu and Barbra Streisand loved it so much that each year she would request it. She also started asking for it at my Spago and Hotel Bel-Air restaurant. It never fails to make me smile when I hear her say, “Wolfgang, please make the pot pie that you do for the Oscars!” It also prompted me to put it permanently on the menu at Hotel Bel-Air because it became so popular. What can guests expect at this year’s ball? As amazing as it seems, this will be my 26th Governors Ball. Every year it feels even more special than before as we always push ourselves to be more innovative. I can’t share any details as the menu is currently top secret but as we’re feeding major celebrities, who eat the very best meals on a daily basis, I promise it will be something exceptional and a real experience to remember. Who do you want to take home an Oscar this year? Parasite was by far the most original film I’ve seen over the past year so I would love to see its director, Bong Joon-ho, win an Oscar for Best Director/Best Original Screenplay. Another movie I loved was Ford v Ferrari starring Matt Damon and Christian Bale because I enjoy watching car races. Brad Pitt is also someone I would like to see win as he’s an actor I’ve seen every year at the post-Oscars celebration and I think he would be a very worthy winner. For those of us not on the Governors Ball invitation list, you’re always invited to experience the celebrity chef’s incredible cuisine at our Wolfgang Puck at Hotel-Bel restaurant, where his famous chicken pot pie is always on the menu. Back to Dorchester Collection Moments Meet pastry chef Jonas Plangger Festive gift wrapping masterclass with Jane Means New experiences at The Dorchester In Conversation With Adrian Sassoon Explore Milan with Ezio Indiani Explore Paris with François Delahaye View the latest issue of Collect, our bi-annual magazine featuring a curated mix of culture, art and lifestyle, together with the latest news from Dorchester Collection hotels. Contact Make a reservation The Dorchester, London 45 Park Lane, London Coworth Park, Ascot Le Meurice, Paris Hôtel Plaza Athénée, Paris Hotel Eden, Rome Hotel Principe di Savoia, Milan The Beverly Hills Hotel, Beverly Hills Hotel Bel-Air, Los Angeles	cc/2021-04/en_middle_0086.json.gz/line1797169
__label__wiki	0.764301	0.764301	Opioid Summaries by State Missouri: Opioid Involved Deaths and Related Harms The NIH HEAL Initiative Opioid Overdose Crisis Benzodiazepines and Opioids Medications to Treat Opioid Use Disorder Research Report Opioid Overdose Reversal with Naloxone (Narcan, Evzio) Opioids Trends & Statistics Opioid Research Findings Funded by NIDA Missouri: Opioid-Involved Deaths and Related Harms Drug-Involved Overdose Deaths In the U.S., there were 67,367 drug overdose deaths reported in 2018, 4.1% fewer deaths than in 2017. The age-adjusted rate declined by 4.6% to 20.7 per 100,000 standard population.1 The decline follows an increasing trend in the rate from 6.1 in 1999 to 21.7 in 2017. Opioids were involved in 46,802 (a rate of 14.6) overdose deaths in 2018—nearly 70% of all overdose deaths. Deaths involving synthetic opioids other than methadone (including fentanyl and fentanyl analogs) continued to rise with more than 28,400 (a rate of 9.9) overdose deaths in 2018. The number of deaths involving prescription opioids declined to 14,975 (a rate of 4.6) in 2018 and those involving heroin dropped to 14,996 (a rate of 4.7).2 Figure 1. Number of drug and opioid-involved overdose deaths in Missouri, by opioid category. Drug categories presented are not mutually exclusive, and deaths may have involved more than one substance. Source: CDC WONDER, 2020. In Missouri, drug overdose deaths involving opioids totaled 1,132 in 2018 (a rate of 19.6)—an increase compared to the 952 (a rate of 16.5) deaths in 2017 (Figure 1). Deaths involving synthetic opioids other than methadone (mainly fentanyl and fentanyl analogs) rose 40% from 618 (a rate of 10.9) in 2017 to 868 (a rate of 15.3) in 2018. Deaths involving heroin or prescription opioids remained stable with a respective 351 (a rate of 6.1) and 265 (a rate of 4.4) deaths reported in 2018.3 Opioid Prescriptions In 2018, Missouri providers wrote 63.4 opioid prescriptions for every 100 persons compared to the average U.S. rate of 51.4. Overall, this represents about a 10 percent decline in Missouri opioid prescriptions since 2006.4 Neonatal Abstinence Syndrome (NAS)/Neonatal Opioid Withdrawal Syndrome (NOWS) NAS or NOWS may occur when a woman uses opioids during pregnancy. To date, there is no standard in NAS/NOWS provider and hospital coding practices.5 As a result, there is variability in the rates reported by states. The national incidence rate of NAS/NOWS in 2016 was 7 cases per 1,000 hospital births.6-7 The highest rates were reported among American Indian/Alaska Native (15.9 per 1,000 births) and White Non-Hispanic (10.5 per 1,000 births) individuals. In 2016, hospital costs for NAS/NOWS births totaled $572.7 million, after adjusting for inflation.8 The rate of NAS/NOWS in Missouri in 2017 was 5.2 cases per 1,000 hospital births and is the most recent data available.6-7 Figure 2. Missouri: Estimated percent of male vs. female with new HIV diagnoses, by transmission category, 2017. Percentages may not add up to 100% due to rounding. Source: CDC NCHHSTP, AtlasPlus. New HIV Diagnoses9 and Prevalence Attributed to Injection Drug Use (IDU) U.S. New Diagnoses: In 2017, 9.7% (3,690) of the 38,226 new HIV diagnoses were attributed to IDU. Among males, 8.6% (2,655) of new diagnoses were transmitted via IDU or male-to-male sexual contact and IDU. Among females, 14.2% (1,035) of new diagnoses were transmitted via IDU.10 U.S. Prevalence: In 2017, more than 1 million Americans were living with a diagnosed HIV infection—a rate of 367.7. Among males, 16.4% (125,274) contracted HIV from IDU or male-to-male sexual contact and IDU. Among females, 20.8% (49,288) were living with HIV attributed to IDU.10 State New Diagnoses: Of the new HIV diagnoses in 2017, 504 occurred in Missouri—a rate of 9.8. Among males, 9.4% of new HIV diagnoses were attributed to IDU or male-to-male sexual contact and IDU. Among females, 8.8% of new HIV diagnoses were attributed to IDU (Figure 2).10 State Prevalence: In 2017, an estimated 12,308 persons were living with a diagnosed HIV infection in Missouri —a rate of 240.5. Of those, 12.9% of male cases were attributed to IDU or male-to-male sexual contact and IDU. Among females, 15.8% were living with HIV attributed to IDU.10 Hepatitis C (HCV) Incidence and Prevalence Attributed to IDU11 U.S. Incidence: In 2017, there were an estimated 44,700 new cases of acute HCV. Among case reports that contained information about IDU, 86.6% indicated IDU prior to onset of acute, symptomatic HCV.12 U.S. Prevalence: An estimated 2.4 million Americans are living with HCV (based on 2013-2016 annual average).12 State Incidence: There were approximately 49 new cases of acute HCV (a rate of 0.8) reported in Missouri in 2017.10 State Prevalence: In Missouri, there are an estimated 40,300 persons living with HCV (a rate of 860 based on 2013-2016 annual average).13 Rates are age-adjusted per 100,000 standard population unless otherwise noted. Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999–2018. NCHS Data Brief, no 356. Hyattsville, MD: National Center for Health Statistics. 2020. Centers for Disease Control and Prevention, National Center for Health Statistics. Multiple Cause of Death 1999-2018 on CDC WONDER Online Database released in 2020. Data are from the Multiple Cause of Death Files, 1999-2018, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. (2020 February 14) Retrieved from http://wonder.cdc.gov/mcd-icd10.html Centers for Disease Control and Prevention. U.S. Opioid Prescribing Rate Maps. (2019, October 3). Retrieved from https://www.cdc.gov/drugoverdose/maps/rxrate-maps.html Lind JN, Ailes EC, Alter CC, et al. Leveraging Existing Birth Defects Surveillance Infrastructure to Build Neonatal Abstinence Syndrome Surveillance Systems—Illinois, New Mexico, and Vermont, 2015–2016. MMWR Morb Mortal Wkly Rep 2019;68:177–180. Healthcare Cost and Utilization Project (HCUP). Neonatal Abstinence Syndrome (NAS) Among Newborn Hospitalizations. (2019, December 12) Retrieved from https://www.hcup-us.ahrq.gov/faststats/nas/nasquery.jsp? Comparisons with earlier estimates are difficult because of the ICD-10-CM transition in 2015. Strahan AE, Guy Jr. GP, Bohm M, et al. Neonatal Abstinence Syndrome Incidence and Health Care Costs in the United States, 2016. JAMA Pediatrics. 2020;174(2):200-202. The term refers to people diagnosed with HIV infection, regardless of the stage of disease at diagnosis. Centers for Disease Control and Prevention. National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) AtlasPlus. (2020, January 30). Retrieved from https://gis.cdc.gov/grasp/nchhstpatlas/main.html. Not all states collect or report data on the incidence or prevalence of Hepatitis C or on how Hepatitis C is transmitted. When available, the data will be included. Centers for Disease Control and Prevention. Surveillance for Viral Hepatitis—United States, 2017. 2019, November 14. Retrieved from https://www.cdc.gov/hepatitis/statistics/2017surveillance/index.htm HepVu. Local Data: Missouri. Retrieved from https://hepvu.org/state/Missouri/ NIDA. 2020, April 3. Missouri: Opioid-Involved Deaths and Related Harms. Retrieved from https://www.drugabuse.gov/drug-topics/opioids/opioid-summaries-by-state/missouri-opioid-involved-deaths-related-harms NIDA. "Missouri: Opioid-Involved Deaths and Related Harms." National Institute on Drug Abuse, 3 Apr. 2020, https://www.drugabuse.gov/drug-topics/opioids/opioid-summaries-by-state/missouri-opioid-involved-deaths-related-harms NIDA. Missouri: Opioid-Involved Deaths and Related Harms. National Institute on Drug Abuse website. https://www.drugabuse.gov/drug-topics/opioids/opioid-summaries-by-state/missouri-opioid-involved-deaths-related-harms. April 3, 2020	cc/2021-04/en_middle_0086.json.gz/line1797173
__label__cc	0.52612	0.47388	Stay Updated on Exciting Dry Creek Valley News & Events Passport to Dry Creek Valley The Vintage Soiree Prelude to Passport Uncorked + Vineyard Tours Transportation & Lodging Geography + Climate Harvest 2018 What to Expect When You Return to Wine Country Start Your Visit Here Dry Creek Valley + Healdsburg Wine Country Lifestyle Interactive Winery Map Passport on Tour – Cruise With Us! Colors of Provence – 2021 Passport to Bordeaux – 2019 Passport to the Douro – 2019 Passport to the Rhone – 2018 Passport to Alaska – 2018 Passport to the Danube – 2017 Passport to the Rhine – 2016 The Flavors of Fall: Dry Creek Valley Wines Autumn in Dry Creek Valley offers up all of the the quintessential trappings of the season one would hope for and is one of the best times of year to come visit us. After the long hot summer, the air becomes brisk enough that we can pull out our coziest sweaters and comfiest jeans. The leaves on the vines turn to brilliant yellows, oranges, and reds, for scenery on par with the best East Coast fall foliage. The best Fall fruits and veggies abound for hearty harvest meals and the cool evenings are wonderful for twilight strolls around Healdsburg and surrounding winery vineyards. It’s also the perfect time to drop into the Healdsburg Farmers Market, which takes place every Wednesday afternoon through October and Saturday mornings through November. Celebrate California Wine Month in Dry Creek Valley This September in Dry Creek Valley In Dry Creek Valley, we like to think every month is California Wine Month, but in September, it’s official. This year marks the tenth year California’s Governor has legally-proclaimed the occasion; Governor Jerry Brown issued an official statement earlier this month to commemorate California’s bounty and its incredible history of winemaking. The first grapes were planted in California by Spanish missionaries for making sacramental wine. By the late 1770s, California’s viniculture was flourishing. In the mid-19th century, a Hungarian Count named Agoston Haraszthy brought a huge range of grape varietals to California and was likely responsible for introducing zinfandel to the state, which is now recognized as one of California’s most iconic wine grapes. Today, our state produces approximately 90% of the United States’ wine. Dry Creek Valley is the proud home of one of the densest concentrations of Old Vine Zinfandel in the world, with vines over 140 years old. For generations, our winegrowers have put tremendous labor and love into our zinfandel and played an integral part in establishing this beloved grape as a California icon. Today, Dry Creek Valley sets the bar for producing world-class, age-worthy zinfandels. Whether you’re a fellow Californian or visiting us from afar, we invite you to raise a glass this month in honor of the early pioneers who first grew wine on our soil and the innovators who keep the industry thriving today. We’ve been celebrating California Wine Month with events all September long, and there are still opportunities to close out the month with a toast. If you’re headed out our way, make sure you take advantage of some of the unique offerings at our member wineries. (more…) Dry Creek Valley Winery: Spotlight Hawley Winery With over 16 years of experience growing for some of California’s most influential wineries including Clos Du Bois and Kendall Jackson, where he was their chief winemaker, John Hawley decided to stake out on his own in 1996. He bought some barrels and fermenters, bonded his garage, borrowed a press, and with a lot of help from friends and family, and considerable toil, became a small wine producer. #SCHarvest14: September Update from Dry Creek Valley #SCHarvest2014: September Update from Dry Creek Valley September is the busiest time for our wineries in Dry Creek Valley, with a fast and furious #SCHarvest14 season well under way. This year is expected to be a vintage of exceptional quality, with somewhat smaller yields than 2012 and 2013, but richly-pigmented, approachable reds and mouthwatering whites. Some producers are calling 2014 the best vintage they’ve ever seen. The king of Dry Creek Valley is zinfandel, where it thrives in the area’s unique climate, with long warm days that allow the fruit to fully ripen and coastal cooling breezes that enable the grapes to retain their acidity and balance through the process of maturation. Zinfandel loves hot weather, and this year delivered a warm spring and a very warm summer. In Healdsburg, there were multiple days in July and August reaching into the mid-90s, but monthly averages overall were around 81 degrees Fahrenheit. All grapes love a big diurnal temperature shift, and in July and August of 2014, daily lows were often more than 20 degrees cooler than daily highs. Interview with a Grape Grower: Bob Littell of Treborce Vineyards Bob and Joyce Littell holding the 2012 Treborce Vineyard Zinfandel from Wilson Winery, Double Gold Winner and Best Zinfandel at the San Francisco International Wine Competiton Every day, Bob Littell goes for a walk through his Treborce Vineyards and inspects his vines, with pruners on his belt, tape in hand, and his dogs–German shorthaired pointers he rescued–for company. If he sees a problem developing, he can nip it in the bud, literally, or if he wants to keep an eye on a particular vine, he can mark it with colored tape so his vineyard manager and crew know to watch it closely. There’s a constant breeze in the vineyard in the afternoon, so Treborce Zinfandel grapes aren’t as susceptible to some of the challenges posed by the area’s prevalent fog. Nonetheless, it takes continuous monitoring and hard work year-round to produce top-notch fruit, which is essential to making top-notch wine. Treborce Vineyards, first planted in 1999, has been producing phenomenal Zinfandel and Petite Sirah grapes ever since. That’s why so many of the wines made from Treborce fruit have won awards. A relatively small property–a mere 10 acres of vines–has made a big impression in the wines of Dry Creek Valley. We spoke to Mr. Littell about what it’s like to be a grower of wine grapes, his favorite vintages, and his impressions of Dry Creek Valley evolution in the 34 years he’s been there. (more…) Dry Creek Valley Culinary Cooperative Dry Creek Valley Passport Dry Creek Valley Wines Meet Your Grower Meet Your Winemaker Wine Country Recipe Wine Paired With Life © Copyright Winegrowers of Dry Creek Valley ® \| All Rights Reserved. Photography © Credits: Charles Gesell, Paul Miller, Quivira Vineyards & Winery, MJ Wickham, Barbara Bourne. Content and images cannot be used without express written permission of Winegrowers of Dry Creek Valley.	cc/2021-04/en_middle_0086.json.gz/line1797174
__label__cc	0.58264	0.41736	Previous articleLinks for this week (weekly) Next articlePlease stop saying brands when it’s about enterprises How can a business rewrite the rules of its industry ? Books I readCustomer relationshipManagement hiroshi mikitani It’s a very common place today to say that the future doesn’t belong anymore to those who master their industry’s rule but to those who rewrite it. Easier said than done. But you’ll find some answers in a book by Hiroshi Mikitan, Rakuten’s founder, in which he explains how he rewrote the rules of his market. Marketplace 3.0: Rewriting the Rules of Borderless Business Hiroshi Mikitani, Rakuten’s CEO and founder. The main idea Following the rules of a market, comply with local conventions and doing it with talent may help to be a market leader at a given moment but not to be sustainable in a fast changing world. More, the step be be too high and the learning curve too long for a new player willing to challenge the incumbents so he would benefit from changing the rules. So he should rewrite the rules himself, be followed by clients, and move the market to a field where the former leaders will be followers and will have to adapt. My takes The book is made of 9 chapters, each one dedicated to a field where Mikitani changed the rules either in the way his company operates, the cultural rules of a very traditionalist country (Japan) or the rule of the market. I’ll focus on what caught my attention. â€¢ The language rules In Japan one does business in japanese and whoever knows the country knows that being fluent in english does not guarantee you’ll be understood in the day-to-day life. But Mikitani decided to make english the single official language. Right after he announced the decision (in english), all the signs in the offices where changed and the CEO hold his first board meeting in english 24 hrs later. If execution is outstanding in country that sticks to its traditions, the “why” is more interesting. Even if the company was growing abroad, english was the mother language of very few people. But it’s the language of international business and the only common denominator at the group’s scale. But there’s something more. Japanese is a very hierarchical language, full of social markers and conveys a lot of unspoken in order no to offend anyone. In other words, compared to the direct nature of english, japanese is not an efficient language to do business. Beyond the language, what Mikitani wanted to change was the mindset. â€¢ The rules of power When businesses speak of empowerment it’s mostly about employees, seldom for clients. At Rakuten, success comes from the fact the company tries to empower both. Employees first, with a simple vision. Employees must have the means their consider necessary to meet the client’s expectations. Even if it means traveling to the other side of the country to meet with a person producing and selling rice, isolated in the mountain while a rational approach would have been to say that the expected outcome does not justify such an investment. Then the client. Empowering the client by allowing him to easily customize his site is counter-intuitive for two reasons. The first is that it has a cost in terms of software development and that’s why Rakuten’s competitors wanted everything to be as standard as possible. The second is that empowering the client means that the latter is able to go without services the company could have sold additionally, what used to be the normal in the industry. Rakuten won because they invested more in the product and go without a potential line of revenue. â€¢ Reinvent internet. What is internet for you ? Technology ? A vending machine ? A network ? For Mikitani it’s a collaboration tool. Building his product on assumptions that were the opposite of his competitor’s helped him to revolutionize his industry. Collaboration between Rakuten, its clients and the clients of its clients. Collaboration between the seller and the buyer on the marketplace. The sales process have shifted from vertical to circular and collaboration improves the experience of all stakeholders. Operations, vision, culture….Mikitani explains everything he did and designed to build and grow Rakuten at the opposite of the codes that prevailed. Examples are only worth what they are worth. Rakuten is a japanese company, some points will seem obvious to some readers (of course…since the model works), others won’t. The major interest of this book if it clearly show that we often try to comply with one industry’s codes, its best-practices, while everything can be challenged. And playing with one’s own rules is often the best way to delight the consumer and create a barrier at the entry of the market for competitors. As a matter of fact if technology can easily be copied, a vision and culture are harder to transpose in another business. Aug 9, 2017 Protecting the corporate culture is not always good Jul 13, 2016 Defining your employee experience (part 2) : the touchpoints Jan 5, 2016 How to Manage Complexity without Getting Complicated Nov 4, 2015 Are the leaders of the Uber Economy here to last ? Sep 4, 2014 Are your employees really hopeless at digital ?	cc/2021-04/en_middle_0086.json.gz/line1797175
__label__wiki	0.848335	0.848335	Lewisham’s new young mayor thanks God for his win by Keji Marell Ricardo/ November 1, 2019/ Left: Femi Komolafe Right: Aaliyah Odedina Lewisham’s new young mayor has thanked God after winning the election with a resounding majority. Femi Komolafe, 15, who attends Bonus Pastor Catholic College in Bromley, secured 1,858 votes. He said of his win: “I feel very happy. I give thanks to God and everyone who supported me. I’m very grateful and I will do my best to repay their faith in me.” Komolafe and his deputy Aaliyah Odedina, from Haberdashers’ Aske’s Knights Academy, will together have a budget of £25,000 to spend on issues relating to the borough’s youth. The results were announced on 17 October. Malcolm Ball, Advisor to the Young Mayor (Lead officer youth participation strategy), London Borough of Lewisham, told EastLondonLines: “Our aim is to set a good example for our young people in Lewisham and promote that hard work never fails. In order to change our borough for the better, we have to be the change and it starts right here. He added: “By helping young people to be informed in politics, knowledgeable about law and keeping them grounded as a community with further education it only promotes good leaders and we need more leaders from all backgrounds representing each borough.” The young mayors are supposed to act as channels for young people’s views in their community by taking them to decision-makers and authority figures. They also receive support from young advisers and the young citizens’ panel and have access to the full range of young people’s forums, networks and school councils. The roles and responsibilities of the young mayor include: supporting and being a spokesperson for the borough’s young people informing and advising the Mayor on issues relating to young people works with the young advisers and young citizens’ panel to inform the work of the mayor, Council and other decision-making bodies oversees a budget of at least £25,000. Results of the young mayor election 2019 Name of candidate First preference votes Second preference votes Total votes Femi Komolafe 1,105 753 1,858 Aaliyah Odedina 1,009 526 1,535 Praise-God Onyeme 994 N/A 994 Tolani Akinfolarin 817 N/A 817 A representative of the borough told EastLondonLines: “We have the longest established young mayor programme in the country (it was started in 2004 by Sir Steve Bullock, former Mayor of Lewisham). It is influential in encouraging other councils to provide this opportunity for young people.” Charities mark World AIDS Day with memorial quilt exhibition across London by Chandrashekar Srinivasan/ UK’s largest graduate art fair comes to Brick Lane by Melania Valeri/ Goldsmiths’ nursery saved by students union by Meabh Nig Uidhir/ Dying is an expensive business for the people of Lewisham by Nalini Sivathasan/	cc/2021-04/en_middle_0086.json.gz/line1797177
__label__cc	0.571125	0.428875	Manager Profiles Down Memory Lane FPL Central Home > Posts tagged "Portugal" Tag: Portugal Nobby Stiles vs Eusébio – One of football’s underrated tale by Aadharsh Shrimanikandan - May 24, 2020 May 24, 2020 27th July 1966: Eusebio of Portugal (left) and Nobby Stiles of England in a duel for the ball during their World Cup semi-final match at Wembley, which England won 2-1. (Photo by Central Press/Getty Images) Living in the Messi-Ronaldo era, we have gifted our eyes to a decade of stunning performances. Mourinho to Tottenham – There’s A Storm Coming by Udhav Arora - November 23, 2019 Let me take you back to 2015. A day prior to the Carabao Cup - then Capital One Cup - Final against Tottenham Hotspur, Chelsea manager Jose Mourinho sat down for his presser. A Mourinho press interview is always entertaining. When asked whether he was offered the Spurs job in 2007 Will 2019 finally be the silverware year for England? by Anubhav Sarker - January 29, 2019 October 2, 2019 Whilst it may be a competition that still has football fans around Europe scratching their heads, the UEFA Nations League has been nothing short of interesting, particularly after the opening group phase threw up plenty of tense games and quite a few surprises along the way. In Group 1, which looked André Gomes – reborn in Merseyside by Peter Lynch - December 24, 2018 October 2, 2019 There is a long, long list of successful Portuguese players to have hit the highs of the Premier League throughout the years. The names of Nani, Ricardo Carvalho, Deco and Paulo Ferreira spring to mind, with a youthful yet precocious Cristiano Ronaldo not to be forgotten about. Manchester City’s Bernardo Portugal Scrape Through To Knockout Stages Despite Late Iran Charge by EADF Feed - June 25, 2018 October 1, 2019 It was a dramatic finish to Group B, as Iran punched above their weight to almost sucker punch Portugal out of the World Cup late on. However, the Portuguese held on and did just enough to make it to the next round. Earlier Ricardo Quaresma had given Portugal the lead Ronaldo strikes again to send Morocco out of the World Cup by Anubhav Sarker - June 20, 2018 October 1, 2019 It was a historic day at the Luzhniki stadium as Cristiano Ronaldo headed home a 4th minute Moutinho cross to become the all-time leading European International goalscorer overtaking Ferenc Puskás of Hungary. However, that goal was one of the rare moments in the match where the Portuguese actually threatened the The Best Goals Scored in the 2018 World Cup so far The 2018 FIFA World Cup is off to a breathtaking start. We have witnessed Volleys, half-volleys, free-kicks, screamers, penalties own goals, VAR and some scintillating displays by teams. Fans from all around the world have been treated to a spectacle thus far and we hope that the entertainment continues. Here Cristiano Ronaldo steals the show as Portugal grab late equaliser against Spain by Varun Shah - June 15, 2018 October 1, 2019 Cometh the hour cometh the man! Fans at the Fisht Olympic Stadium in Sochi were treated to an early 'Game of the Tournament' contender as Cristiano Ronaldo scored yet another hattrick to steal a late 3-3 draw for Portugal vs Spain. It was an absolute treat of a match, especially for The Scout’s Guide to the World Cup: Group B We continue our Scout's guide as FootballMR takes a look at Group B Spain Player – Álvaro Odriozola Position: Right-Back Age: 22 Caps: 3 Goals: 1 Odriozola was selected for the Spain squad ahead of players such as Arsenal’s Hector Bellerin and Barcelona’s Sergi Roberto yet only making his debut in 2017 towards Group B analysis: Battle of the Iberian cousins by Ganapathi Ramanathan - June 5, 2018 October 1, 2019 Group B consists of an exciting cocktail of power, pluck, passion, and experience. While Spain is an outright favourite to win the World Cup, the group consists of the ever-formidable Portugal, a well rounded Moroccan squad, and a spunky Iranian side. All the games in this group shall be a 5 World Cup Group Stage Matches to Look Forward To by EADF Feed - May 8, 2018 October 1, 2019 The domestic campaigns around Europe are set to come to a close later this month, which means it’s officially time to start getting excited about the upcoming World Cup. The world’s biggest football tournament will go down in Russia starting in mid-June, and each of the 32 teams involved is	cc/2021-04/en_middle_0086.json.gz/line1797181
__label__wiki	0.585106	0.585106	Funny Professors There's a piece in the Chronicle of Higher Ed about eccentric professors. From the first paragraph it seems like it's going to be a lot of fun: Ask anybody what adjective goes best with the word "professor," and the answer will almost certainly be "absent-minded," or possibly "nutty." Popular culture is full of addlebrained academics, whether they be villainous madmen like Professor Morbius in Forbidden Planet or Sherlock Holmes's archenemy Professor Moriarty; crazy cranks like Professor Emmett Brown in Back to the Future, or well-meaning but harebrained eccentrics like Professor Brainard in The Absent-Minded Professor, Professor Branestawm in Norman Hunter's children's television series, Professor Pat Pending in the Hanna Barbera cartoon Wacky Races, or Professor Dumbledore of Harry Potter fame. She forgot Flubber, and the two Eddie Murphy Nutty Professor movies. Unfortunately, the fun doesn't last. The article is really a kind of meditation on the status of mental illness in academia, with special attention to issues like Asperger's Syndrome and the prevalence of anti-social behaviors amongst academics. It's well worth reading and discussing of course. But I wanted to focus on the fun part this morning: the stereotype of the nutty professor. I'm really bored with the old hollywood cliché of the earnest, bearded prof (i.e., Robin Williams in that unbearable piece of faux-Indie sap, Good Will Hunting). I think we professors really ought to market our comedic powers more aggressively. I've often wondered why, on sites like "Rate Your Professor," there is no question about whether the professor is funny. Funny is important! Humor is almost as good as knowing what you're talking about (in some cases, it can even be a helpful substitute). Hollywood (and Bollywood) can help us win this fight. One of the best funny professors ever on TV was "The Professor," from Gilligan's Island. (Incidentally, I was shocked to discover just now from IMDB that Gilligan's Island was only on the air between 1964 and 1967. Watching this show as a kid in the 1970s-80s, I suppose I thought I was watching its original run.) The Professor on Gilligan's Island is the endless comedic foil in the show -- its laughably tweedy heart and soul. And he's the source of such comedic gems as: Professor Roy Hinkley: Well, that glue is permanent! There's nothing on the island to dissolve it. Why do you know what it would take? It would take a polyester derivative of an organic hydroxide molecule. Thurston Howell III: Watch your language! You're in the presence of a lady! Ouch. Ok, maybe not that funny after all. Still, I've often wondered if I should start wearing tweed sportscoats to class, just to weird my students out (and keep them awake). I might also start carrying an old-fashioned tobacco pipe (which will remain unlit of course). What about funny female professors? I can't think of any from TV or the movies (I know plenty in real life). For that matter, there aren't even that many women-as-professor roles back there. One recent film that comes to mind is the rather steamy crime drama In The Cut, where Meg Ryan plays an English professor. Not a great film, and definitely not funny. The diabolical Dr. No from the old James Bond movie of the same title, and Star Trek's Dr. Spock also play "professors" in their respective contexts, though they aren't necessarily intentionally comedic. Still, Star Trek often worked Spock for laughs (think of the friction between Spock and Scotty), and Dr. No is funny because it seems so campy and absurd now (one can only watch it through the lens of Austin Powers). Bollywood has its own professors -- IMDB turns up old films like Khiladi or, even further back, Kora Kagaz. I admit I haven't seen either of them. More recently, perhaps, one thinks of the faculty of the medical school in Munnabhai M.B.B.S.. Can anyone think of other amusing "professor" characters, from either the Bollywood or Hollywood canons? (Or, if you must, from literature) Suvendra Nath Dutta said... If you include Bengali films then there are several. One particularly interesting one (though not strictly a professor) is the "Jadugar" character in Satyajit Ray's (well, what did you expect?) "Goopy Gyne Bagha Byne". He is a scientist for hire who works in his lab, speaks a peculiar language, has enormous powers. He has no loyalties except to money and sells his abilities to the highest bidder. Then of course there is (also Ray's) "Dr. Gupta" in "Ganashatru", which is a version of Ibsen's enemy of the people. What about Amitabh Bacchchan in "Mohabattein"? He is a royal p in the a with all his high-faultin' moralizing against which Sharukh Khan plays the equally sickly sweet rebel with a good heart etc. And the recent "Black" in which he is a teacher if not a professor. Films like Kuch Kuch hota hai have the professor sidekicks who nod knowingly if they are aiding and abetting the romance plot or glower and thunder if not. Anupam Kher plays the glowering principle+father. Wait, these are set in college right? Not high school? Of course, needless to say, none of these resemble any college that I studied in or visited during my undergrad years in India. There were no cell phones, no cars, no designer clothes in sight--only University special buses and the high academic mindset fuelled by second wave feminism! Professor Brown in Mind your Language, the british comedy from the 70's !! Amitabh in Chupke Chupke. Emma Thompson in Junior. David Schwimmer in Friends (the British accent!) Amardeep, tsk, tsk. You forget the best professor on film of them all- one Indiana Jones. That said, he wasn't particularly funny in the few scenes we saw of him at lecture. But he was amusing. The treatment of female professors in film or tv is an absolute shame. I think the only amusing one I've ever seen is Frances McDormand in Almost Famous. She was both funny and strong. I can't count Emma Thompson because I refused to watch Junior, but I could see her pulling it off in otherwise tripe-like film. Scott Eric Kaufman said... I know Emma Thompson's already been mentioned--and I know that in the fiction of the film she's not at all funny in the classroom--but her drier-than-dust performance in Wit's about as funny as slow death by cancer can be. Having typed that, I'm almost inclined to untype it. But she's really, really funny in Wit. electrostani said... Scott, I'm pretty sure I saw Wit, and yes, she was funny there. But I haven't seen this film Junior that a couple of people have mentioned. I'll look for it! Indiana Jones works, it seems to me. When he's not cooly gunning down oriental swordsmen (demonstrating his American pragmatism), he's often doing the "befuddled professor" thing. Perhaps we could say he's the funny professor on a colonialist field trip. So many interesting Indian films. I haven't seen Mohabbatein, though I have seen Black. I didn't think much of Amitabh Bachchan there, but he certainly seems to be doing the professor thing. (Not funny, though) I'm pretty sure I've seen Chupke Chupke, though I don't remember anything about it. (I might also be confusing it with Chori Chori Chupke Chupke, which I also don't remember. Huge black holes of memory when it comes to many Hindi films...) I think the dearth of funny women professor movies needs to be rectified. I propose we concoct a proposal for a film where a coterie of funny women professors have some kind of adventure... Any takers? The obvious age demographic is Sex and the City + 10 years. But maybe it might be more interesting if we mix up the age groups? MD said... Well, I was going to bring up Munnabhai MBBS which I love, except for the weird scene where they kill the Japanese? tourist. That was odd.... I read the first part of this article and thought: well, that explains a lot of faculty meetings..... Mr. Spock. No tension with Scotty. With Dr. McCoy. Not actually a character I think as professiorial. Don't really think of Dr. No that way either, though. He's really a scientist/technician: different trope. Tim Burke Prithi Shetty said... What a delightful post ! Rating a Professor, say in feedback, on funny-quotient may only increase the pressure on them. And they may stop being funny ! Humor is definitely important, to stay awake in most classes. Funny female scientist (not professor yes) reminds me Emma Thompson's character in Junior. And in Hindi Movies, there are Professor Parimal Tripathi and Prof Sukumar Sinha from Chupke Chupke. They were really funny, esp at playing with the language. How can you forget Prof. Higgins from My Fair Lady, what a delightful character & ofcourse sexy Sushmita Sen always droped in chiffon sarees in Main Hoon Na. Teji draped sorry RajpaL said... Would Shammi Kapoor in the classic comedy 'Professor' count? He dresses up as an old professor to get a job. One of those old B&W (or was it colour) comedies of yesteryears!! Good wholesome family entertainment! Teji, Of course, Professor Higgins! I forgot. He is funny, though he's also so mean to Audrey Hepburn he gives the rest of us a bad name. Rajpal, I haven't seen "Professor," though it sounds just perfect. And Tim, yes, I see what you mean about Spock especially. I included him because I was thinking of his character as fitting the general type: comically over-informed, completely emotionally detached, slightly eccentric looking. But maybe there should be a separate category for Commanders Spock and Data: the scientific unconscious. Rediff did a feature (slideshow really) on "teaching in the movies" (not necessarily at the college level). But here it is, and it begins with Sushmita Sen in "Main Hoon Na": http://specials.rediff.com/movies/2005/sep/05teach1.htm?q=mp&file=.htm Mendi Obadike said... Hmm. Some of my students have commented that I'm funny, but I'm usually shooting for 'corny'. I still remember lessons from my corny/funny teachers in high school. Another filmic female English professor: Barbara Streisand in "The Mirror Has Two Faces" Saheli said... Not so funny: In the Cut, A Beautiful Mind. Not quite a professor: Infinity, about Feynman. The TV Movie Murder 101 with Pierce Brosnan was mildly amusing at times. I always thought Jimmy Stewart's character in Rope was a professor, but according to IMDB he's a schoolteacher. Haven't yet seen Mona Lisa Smile. Before Core burned a hole in my brain on the bus between Boston and NY, I noted that they showed a prof teachin in class. Does Cornel West in the Matrix count? That was kinda funny. Mridula said... There is this Bollywood movie, Munna Bhai MBBS where Bomman Irani is a professor of medicine and he is funny in a cliched role. Still Irani has done justice and much appriciated for his work. Jane Sunshine said... This is a really interesting post. The only high profile female professor type from Hollywood that I can think of is Julia Robert's in Mona Lisa Smile and that was so blearghhhh...I agree with Amardeep, some people should get together and make a movie about female professors ala sex and the city. But why +10 years? There are loads of young female professors whom I know of. Ray Davis said... The fourth season of "Buffy the Vampire Slayer" featured a formidable feminist theorist professor in the University of California system who turned out on the side to also run a paramilitary organization and be creating a Super-Frankenstein man (as a tribute to Mary Shelley, no doubt). My favorite fictional female professor used to be Professor Burber from the extraordinary comic strip "9 Chickweed Lane". She taught chemistry and had frequent (and very realistic) battles with lazy bonehead students and sexist bonehead administrators. Sadly, she recently resigned and moved to a farm.	cc/2021-04/en_middle_0086.json.gz/line1797185
__label__wiki	0.676269	0.676269	Announcing the 2012 Gunther & Lee Weigel Medical School Scholarship Winners The ENF is proud to announce the 2012 Gunther and Lee Weigel Medical School Scholarship recipients. Thanks to the generosity of Mrs. Gunther Weigel, the following six Elks scholars will each receive $20,000 to help them pursue their dreams of becoming doctors. Amy Haldeman Cohee 2003 Most Valuable Student sponsored by Waynesboro, Pa., Lodge No. 731 Medical School: East Tennessee State, Quillen Medical Why this specialty? “I would like to practice in a rural primary care setting, most likely as a family practice physician. Because I grew up in rural Pennsylvania, I have been exposed to some of the attitudes toward health and health care that often characterize rural communities.” What did your ENF scholarship mean to you? “I recognize that I have been given an experience that I likely could not have provided for myself. In gratitude for the contribution that so many individuals have made to my education, I hope to pay that gift forward to others.” Eraj Din 2008 Most Valuable Student sponsored by Elgin, Ill., Lodge No. 737 Medical School: Rosaline Franklin University of Science and Medicine Specialty: Pediatrics/Neonatal Why this specialty? “Through my service involvements, I have worked closely with young children. My career choice will compliment my service work and provide me with the opportunities to give back.” What did your ENF scholarship mean to you? “The Elks National Foundation and its scholarship symbolize hope in my life. The Elks National Foundation gave my parents hope when they feared their child might not be able to pursue an education. This foundation has inspired me to pursue my dream career and one day help others to do the same.” Raza Hasan 2008 Most Valuable Student sponsored by Essex, Md., Lodge No. 1866 Medical School: University of Missouri – Kansas City School of Medicine Why this specialty? “Internal medicine is a cornerstone of preventative medicine—trying to help patients escape the infection of disease, or to provide treatment before symptoms worsen.” What did your ENF scholarship mean to you? “All Elks scholars, although very diverse, share a similar basic belief, a certain goal: their aspiration to try their hardest and aim for the best. With this motivation and drive, Elks scholars are able to dream and fulfill their ambitions. By the grace of the Elks scholarship, I was able to fund my undergraduate education, without having to limit my dreams financially.” Megan Maguire-Marshall 2008 Legacy sponsored by Gallup, N.M., Lodge No. 1440 Medical School: University of New Mexico School of Medicine Specialty: Family Medicine and Rural Medicine Why this specialty? “I grew up in Gallup, New Mexico, a culturally rich, but economically poor community. Communities like Gallup have limited resources and struggle to hold on to heal care providers, teachers, and other professionals for extended periods of time. I believe I can contribute to health professional shortage areas like my hometown by being a primary care provider.” What did your ENF scholarship mean to you? “While a tuition scholarship made it possible for me to attend an expensive institution away from my home state of New Mexico, there was still a financial burden on my family to pay for room, board, fees and textbooks, which the ENF scholarship allowed me to meet.” Sean Maiolo 2000 Most Valuable Student sponsored by Prescott, Ariz., Lodge No. 330 Medical School: University of Arizona College of Medicine – Phoenix Specialty: Reconstructive Plastic Surgery Why this specialty? “As a soldier and Emergency Medical Technician, I have seen firsthand the lifelong effects of disfiguring traumatic injuries. My greatest desire is to build a reconstructive plastic surgery practice dedicated to giving hope to soldiers, trauma victims, and children suffering from disfiguring injuries and birth defects.” What did your ENF scholarship mean to you? “As a first generation college graduate, I understand that not everyone with the motivation and desire to help others has the opportunity to pursue a higher education. Without the generosity of organizations like the Elks, I would not have been able to attend the school of my choice.” Lindsay Poston 2006 Most Valuable Student sponsored by Woodland, Calif., Lodge No. 1299 Medical School: Pritzker School of Medicine at the University of Chicago Specialty: Internal Medicine and Pediatrics Why this specialty? “My time working in free community health clinics has opened my eyes to a great dearth of primary care physicians. I’m particularly passionate about primary care because unlike many specialties, it can be preventative rather than reactive.” What did your ENF scholarship mean to you? “Being an Elks scholar means being supported by—and being a part of—a community that share my values and commitment to serving others. No matter where I am living, I fondly read the updates and stories of scholars like me and I feel connected to something bigger. In this way, the Elks National Foundation has nurtured, challenged and inspired me.”	cc/2021-04/en_middle_0086.json.gz/line1797188
__label__wiki	0.869399	0.869399	Badass Habits: Cultivate the Awareness, Boundaries, and Daily Upgrades You Need to Make Them Stick (Hardcover) By Jen Sincero Murder on the Orient Express: A Hercule Poirot Mystery (Hercule Poirot Mysteries #10) (Paperback) Kitchen Confidential Updated Ed: Adventures in the Culinary Underbelly (Paperback) The Barnabus Project (Hardcover) By Terry Fan, Eric Fan, Devin Fan The House of Hades (The Heroes of Olympus, Book Four (new cover) (Paperback) The Night Before Christmas (Hardcover) Grandpa and Me (Board book) By Danielle McLean, Alison Edgson (Illustrator) I Survived the Sinking of the Titanic, 1912 (I Survived #1) (Paperback) The Berenstain Bears and the Trouble with Chores (Paperback) By Jan Berenstain, Jan Berenstain (Illustrator), Stan Berenstain Once I Was You: A Memoir of Love and Hate in a Torn America (Hardcover) By Maria Hinojosa The Stonekeeper's Curse (Amulet #2) (Paperback) By Kazu Kibuishi Becoming a Good Creature (Hardcover) By Sy Montgomery, Rebecca Green (Illustrator)	cc/2021-04/en_middle_0086.json.gz/line1797189
__label__cc	0.682791	0.317209	eBook Makes Get eBook PDF Community Writing Community Writing addresses you as an active and responsible citizen by helping you to learn about writing within your own community experiences. “ Community” can mean any group that you identify with: a neighborhood, a school Author: Paul S. Collins Category: Language Arts & Disciplines DOWNLOAD → Community Writing: Researching Social Issues Through Composition employs a series of assignments that guide students to research and write about issues confronting their individual communities. Students start by identifying a community to which they belong and focusing on problems in it, and then analyze possible solutions, construct arguments for them, decide which are likely to succeed, and consider how to initiate action. This is a primary text for first-year composition courses, covering the basics of the writing process. The assignments are recursive. Short writing assignments in each chapter build up to longer papers. Each of the assignment questions is accompanied by a guide to thinking about and writing the assigned paper, followed by a short Focus On reading that provides a brief account of community activism, a media case study, or a notable success story. The longer papers are accompanied by in-class peer reading groups. Each successive peer reading attempts a higher level of conceptual critique. By working together throughout the semester, students create increasingly adept peer groups familiar with all stages of each other's research. The book is carefully structured, but there is plenty of "give" in it, allowing instructors to be flexible in adapting it to the needs of their students and courses. Community Writing: * is distinguished by pedagogy based on a collaborative, process-oriented, service learning approach that emphasizes media critique and field research on community issues chosen by individual students; * answers real student questions, such as: Where do I find articles on my topic? What if evidence contradicts my hypothesis? How do I know if a source is biased?; * is web-savvy--guides students into building their own Web sites, including a unique guide for critiquing the design and veracity of other people's websites; and * is media-savvy--topics include media monopolies, spin control, dumbing down, misleading statistics, the Freedom of Information Act, "crackpot" authors, political rhetoric, and fallacious argumentation. Creative Writing in the Community After several of these workshops, I felt that writers needed a larger venue than just the classroom in which to share their ... We enter with common interests (in reading and writing) and the shared experience of living in the same community, Author: Terry Ann Thaxton Publisher: A&C Black Creative Writing in the Community is the firstbook to focus on the practical side of creative writing. Connecting classroomexperiences to community-based projects, it prepares creative writing studentsfor teaching in schools, homeless centres, youth clubs and care homes. Each chapteris packed with easy-to-use resources including: specific lesson plans; case studies of students working with community groups; lists of suitable writing examples; "how to..." sections; examples and theoretical applications of creative writing pedagogy and techniques; reflection questions; writings by workshop participants. Enhanced by contributions from directors,students and teachers at successful public programs, Creative Writing in the Community is more than an essential guidefor students on creative writing courses and leaders of community-basedlearning programs; it is practical demonstration of the value of art insociety. Service Learning and Writing Paving the Way for Literacy ies through Community Engagement Afterword: Community. Writing. Pedagogies. in. the. Spirit. of. the. New. Mestiza. Thomas. Deans. Abstract. This brief postscript considers several recurrent themes in the previous chapters (reflection, multiple literacies, assessment, diversity, ... Author: Isabel Baca Publisher: BRILL Demonstrates how writing instruction and/or writing practice can complement community engagement and outreach at local, national, and international contexts. This title discusses service-learning as a teaching and learning method and its integration with writing. The Writing Center Director s Resource Book Whereas the community tends to accept without question that Salt Lake Community College provides the Community Writing Center as a service to the community. writing center directors from around the country make it their first question at ... Author: Christina Murphy The Writing Center Director's Resource Book has been developed to serve as a guide to writing center professionals in carrying out their various roles, duties, and responsibilities. It is a resource for those whose jobs not only encompass a wide range of tasks but also require a broad knowledge of multiple issues. The volume provides information on the most significant areas of writing center work that writing center professionals--both new and seasoned--are likely to encounter. It is structured for use in diverse institutional settings, providing both current knowledge as well as case studies of specific settings that represent the types of challenges and possible outcomes writing center professionals may experience. This blend of theory with actual practice provides a multi-dimensional view of writing center work. In the end, this book serves not only as a resource but also as a guide to future directions for the writing center, which will continue to evolve in response to a myriad of new challenges that will lie ahead. Circulating Communities Tiffany Rousculp, “Introduction” in Wisdom in Words: A publication of the DiverseCity Writing Series (SLCC Community Writing Center, 2000), 1. 4. SLCC Community Writing Center, “DiverseCity Writing Series Mission Statement” in sine cera: ... Author: Paula Mathieu Publisher: Lexington Books Circulating Communities: The Tactics and Strategies of Community Publishing, edited by Paula Mathieu, Steve Parks, and Tiffany Rousculp, represents the first attempt to gather the myriad of community and college publishing projects, providing not only history and analysis but extended samples of the community writing produced. Rather than feature only the voices of academic scholars, this collection features also the words of writing group participants, community organizers, literacy instructors, librarians, and stay-at-home parents as well. In libraries, community centers, prisons, and homeless shelters across the US and around the world, people not traditionally understood as writers regularly come together to write, offer feedback, revise, publish and most importantly circulate their words. The vast amount of literature that these community-publishing projects create has historically been overlooked by scholars of literature, journalism, and literacy. Over the past decade, however, higher education has moved outward, off campus and into the streets. Many of these efforts build from writing and publication projects that extend back over decades, are grassroots in nature, and are independent of college efforts. Circulating Communities offers a unique glimpse into how neighbor and scholar, teacher and activist, are using writing and publishing to improve the daily lives on the streets they call home." A Community Writing Itself Interviews about art and life with contemporary experimental American writers. Author: Sarah Rosenthal Publisher: Columbia University Press Writing the Community Community Service Writing: Problems, Challenges, Questions by Nora Bacon I have a section in my file cabinet labeled "CSW Success Stories." In it are stored testimonies gathered over seven years — teachers' reports, students' reflective ... Author: Linda Adler-Kassner Publisher: Stylus Publishing, LLC. This volume is part of a series of 18 monographs on service learning and the academic disciplines. These essays highlight some of the benefits and problems of service-learning in the college composition curriculum and present further areas for study. Following the Introduction, "Service-Learning and Composition at the Crossroads," by Linda Adler-Kassner, Robert Crooks, and Ann Watters, and an Introduction, "Service-Learning: Help for Higher Education in a New Millennium?" by Lillian Bridwell-Bowles, the essays are: "Writing across the Curriculum and Community Service Learning: Correspondences, Cautions, and Futures" (Tom Deans); "Community Service Writing: Problems, Challenges, Questions" (Nora Bacon); "Community Service and Critical Teaching" (Bruce Herzberg); "Rhetoric Made Real: Civic Discourse and Writing beyond the Curriculum" (Paul Heilker); "Democratic Conversations: Civic Literacy and Service-Learning in the American Grains" (David D. Cooper and Laura Julier); "Partners in Inquiry: A Logic for Community Outreach" (Linda Flower); "Service-Learning: Bridging the Gap between the Real World and the Composition Classroom" (Wade Dorman and Susann Fox Dorman); "Systems Thinking, Symbiosis, and Service: The Road to Authority for Basic Writers" (Rosemary L. Arca); "Combining the Classroom and the Community: Service-Learning in Composition at Arizona State University" (Gay W. Brack and Leanna R. Hall); "The Write for Your Life Project: Learning To Serve by Serving To Learn" (Patricia Lambert Stock and Janet Swenson); and "On Reflection: The Role of Logs and Journals in Service-Learning Courses" (Chris M. Anson). Appended are a 39-item annotated bibliography and a list of program descriptions by institution. (All papers contain references.) (SM) Writing in Community We want this book to be an invitation to join the writing community, to write in community. We want to challenge you, inspire you, show you how to start a writing group or improve the group you have. When we speak of a writing group, we ... Author: Lucy Adkins Publisher: BQB Publishing Category: Self-Help Writing in Community is a book of inspiration and encouragement for writers who want to reach deep within themselves and write to their fullest potential. There is magic in a successful writing group. This book helps writers tap into that magic, and with gentle wisdom and humor, experience unprecedented breakthroughs in creativity. A Guide to Creating Student staffed Writing Centers Grades 6 12 In time , however , Dave and his writing center staff may decide to create a wide variety of special activities and programs to serve their school and community . As Peggy Silva taught us , such programming helps create a community of writers Author: Richard Kent Publisher: Peter Lang Writing centers are places where writers work with each other in an effort to develop ideas, discover a thesis, overcome procrastination, create an outline, or revise a draft. Ultimately, writing centers help students become more effective writers. Visit any college or university in the United States and chances are there is a writing center available to students, staff, and community members. A Guide to Creating Student-Staffed Writing Centers, Grades 6-12 is a how-to and, ultimately, a why-to book for middle school and high school educators as well as for English/language arts teacher candidates and their methods instructors. Writing centers support students and their busy teachers while emphasizing and supporting writing across the curriculum. Building a Writing Community Bauer, Marian Dane. What's Your Story; A Young Person's Guide to Writing Fiction. New York, NY: Clarion Books, 1992. Benjamin, Carol Lee. Writing for Kids. New York, NY: Thomas Y. Crowell, 1985. Dubrovin, Vivian. Write Your Own Author: Marcia Sheehan Freeman Publisher: Maupin House Publishing, Inc. Explains how to create the philosophical and physical environment needed to develop successful writing communities in which students learn, practice, and apply writing-craft skills. Brain Friendly Strategies for Developing Student Writing Skills Classroom: CommuNity. WritiNg. PartNers. The original project, called Parents as Writing Partners, began in 1988. Back then most of my students lived with both their parents. Over the years as society changed, I realized more and more of my Author: Anne Hanson Publisher: Corwin Press Aligned with core principles of effective instruction, this resource provides brain-compatible strategies, reflection questions, and cross-curricular writing activities to boost students' writing and achievement. Writing Groups Inside and Outside the Classroom metaphor legitimizes the role of conflict and difference in literacy communities. What makes this SCWW community writing group a particularly interestingcontact zoneisthatit exists outside the hierarchical power structures ofthe university. Author: Beverly J. Moss This unique collection considers the nature of writing groups inside and outside the academic environment. Exploring writing groups as contextual literacy events, editors Beverly J. Moss, Nels P. Highberg, and Melissa Nicolas bring together contributors to document and reflect on the various types of collaborations that occur in writing groups in a wide range of settings, both within and outside the academy. The chapters in this volume respond to a variety of questions about writing groups, including: What is the impact of gender, race, and socioeconomic class on power dynamics in writing groups? When is a writing group a community and are all writing groups communities? How does the local community of a writing group impact the participation of group members in other local or global communities? How does the local community of a writing group impact the participation of group members in other local or global communities? What actions contribute to a strong community of writers and what actions contribute to the breakdown of community? When and for whom are writing groups ineffective? *What is it about belonging to a community of writers that makes writing groups appealing to so many within and beyond the academy? Each chapter highlights how writing groups, whether or not they are labeled as such, function in various spaces and locations, and how collaboration works when writers from a variety of backgrounds with diverse interests come together. Writing Groups Inside and Outside the Classroom illustrates that writing groups outside of the academy are worthy of study and serve as important sites of writing and literacy instruction. Offering significant insights into the roles of writing groups in literacy and writing practice, this volume is appropriate for scholars and teachers of writing, rhetoric, composition, and literacy; for writing center administrators and staff; and for writing group participants. British Women Poets and the Romantic Writing Community ... works opened up wholly new vistas on the landscape of the diverse and dynamic writing community that existed in the British Isles between the outbreak of the war with the American colonies and the accession of the youthful Queen Author: Stephen C. Behrendt Publisher: JHU Press This study will be a key resource for scholars, teachers, and students in British literary studies, women’s studies, and cultural history. Writing in a Community of Practice There Inkshedders across Canada happily offered their insights into such matters as the difference between writing instruction in the United States and Canada, plagiarism, and writing centres in Canada (including their history, development, ... Author: Miriam E. Horne Publisher: Trafford Publishing The role of writing in building community is an important topic. This book moves us through that process by describing the journey into the fold of a particular writing community. While it may be helpful to describe community membership as a typical journey, it is nonetheless important to interrogate this journey of belonging through examining the specific nature of one such community. Given that both the nature of collaborative writing and community practices are situated, the journey itself is also situated practice. The writing community described in this text is Inkshed, an academic collaborative that has existed over twenty-five years at the publication of this text. What is Inkshed? It is the nickname of the Canadian Association for the Study of Language and Learning (CASLL), an organization that has the purpose of exploring relationships among research, theory, and practice in language acquisition and language use, particularly in the Canadian context. Inkshed has a website, LISTSERV, publication group, and annual meetings. The membership is a mixture of mainly Canadian academics and professional writers from across the provinces and territories. Regional members organize a yearly conference. For these conferences, members are provided with a guiding theme that creates a common thread for member presentations. Following and often during presentations at each one of these conferences, a special type of sharing takes place: members write responses to each of the presentations; they literally shed ink on the presentations and then place these response writings on conference tables for others to read and engage in further writing, responses to the responses. Writings in response to the speakers are then gathered together by a team of conference organizers, edited and distributed so that all members, including the presenters, can read the written responses of their community throughout the duration of the conference. As the technology has become available, some responses have been posted online. This writing-in-community response was a forerunner of the current social networks, which became an inevitable consequence of writing collectives online such as Wikis, Twitter, online letters to the editor, fan fiction, or Facebook. Inkshedders have always described this conference as a working conference and described the collaborative nature of their responses in writing as a far deeper experience than merely listening to a speaker and/or asking questions at the end of a session. The audience is purposefully engaged. The investment of self is personal. In this text, Miriam Horne has addressed the nature of this deeper experience. She notes that it is a risk-taking venture and that the feeling of membership goes beyond paying fees to belong. Inkshedders must pay their dues in other ways toward full membership. Legitimate peripheral participation (LPP), as introduced by Jean Lave and Etienne Wenger, is only the beginning. Horne's book provides insight into knowledge about membership and invites us to think about our own and other communities of membership such as school classrooms, Web 2.0, churches, and clubs. We see that peripheral participation is an important and tenuous aspect of membership and that success in this outside margin is important to the nature of how one sees oneself later, on the inside of membership. Horne's interrogation of what it means to become an Inkshedder allows us to interrogate the meaning of membership through collaborative writing, and determine what it really means to become part of a community. The book describes a personal journey into academic writing in community and is a good read for anyone who aspires to that destination. Literacy Language and Community Publishing 3 Working With Words : Active Learning in a Community Writing and Publishing Group - - - - - - - MICHAEL HAYLER ... based community publishing project , is one of about 50 member groups of the British Federation of Worker Writers and ... Author: Jane Mace Publisher: Multilingual Matters The purpose of this collection is to contribute to views and policies about adult literacy. From a range of experiences in adult literacy, language education and community publishing, each contributor draws on the practical business of working for good quality learning and development opportunities. Each chapter describes a particular context or site in which writing takes place, such as adult language classes; each author then explores relevant issues, such as blocks to writing and each then asserts features from experience which constituted good practice. The chapters are grouped into three sections, broadly addressing three themes common to writing development with adults both in educational settings and in the context of community writing and publishing groups. Word for Word Writing for Self Discovery Spiritual Renewal and Community Building 13 In the writing classes led by the Rev. Rankin, as well as in those led by myself and others, several common theological themes have emerged in the explication of one's life journey. These themes include: the changing concept of the Sacred ... Author: Robin L., MDiv Zucker Publisher: Lulu.com An exploration of the traditions and benefits of expressive and spiritual writing with a minister in a congregational setting. A complete five-week curriculum included. Writing Signs Community. For some five hundred years before the Fatimid public text first appeared, officially sponsored writing was used throughout the eastern Mediterranean to address group audiences. The archaeological remains from the time of the ... Author: Irene A. Bierman Publisher: Univ of California Press Irene Bierman explores the complex relationship between alphabet and language as well as the ways the two elements are socially defined by time and place. She focuses her exploration on the Eastern Mediterranean in the sixth through twelfth centuries, notably Cairo's Fatimid dynasty of 969-1171. Examining the inscriptions on Fatimid architecture and textiles, Bierman offers insight into all elements of that society, from religion to the economy, and the enormous changes the dynasty underwent during that period. Bierman addresses fundamental issues of what buildings mean, how inscriptions affect that meaning, and the role of written messages and the ceremonies into which they are incorporated in service of propagandist goals. Her method and conclusions provide a pioneering model for studying public writing in other societies and offer powerful evidence to show that writing is a highly charged and deeply embedded social practice. Building a Community of Writers Writers Are as Writers Do A MATERIALSMATERIALS • bulletin board or chart paper Teach children the following poem. Have children chant this poem every morning to remind them about the importance of writing. Display the poem on an Author: Kim Cernek Publisher: Creative Teaching Press "Featuring: writer's workshop teaching techniques ; activities directly linked to writing standards."--Cover. George Cram Cook, the eccentric poet and offbeat teacher — and former member of the Tabard writing club — probably deserves the honor of offering the first creative writing course at Iowa. In the spring of 1896, he offered a "Verse- making ... Author: Robert Dana Publisher: University of Iowa Press "We do not pretend to have produced the writers included in this book. Their talent was inevitably shaped by the genes rattling in ancestral closets. We did give them a community in which to try out the quality of their gift.". Writing Women s Communities 1 Introduction Writing across Communities What is more is that identity is always in part a narrative, always in part a kind of representation. It is always within representation. Identity is not something which is formed outside and then we tell Author: Cynthia G. Franklin Publisher: Univ of Wisconsin Press Category: Social Science Beginning in the 1980s, a number of popular and influential anthologies organized around themes of shared identity—Nice Jewish Girls, This Bridge Called My Back, Home Girls, and others—have brought together women’s fiction and poetry with journal entries, personal narratives, and transcribed conversations. These groundbreaking multi-genre anthologies, Cynthia G. Franklin demonstrates, have played a crucial role in shaping current literary studies, in defining cultural and political movements, and in building connections between academic and other communities. Exploring intersections and alliances across the often competing categories of race, class, gender, and sexuality, Writing Women’s Communities contributes to current public debates about multiculturalism, feminism, identity politics, the academy as a site of political activism, and the relationship between literature and politics. Fairy Tale of the White Man Functional Clothing Design Dont Take No for an Answer Oh, My Snickerdoodle! Kiss Me Like You Mean It Monarchs of the Sea Hollywood Enigma The Complete Tales: v. 1 Windows Virus and Malware Troubleshooting Informed Consent and Clinician Accountability How to do Accounting I Text Replenish the Earth City Maps Saveh Iran Iamblichus on The Mysteries Music in Every Room A Textbook of Modern Toxicology Favorite Food at Home F in Spelling Brilliant Activities for Creative Writing, Year 5 Product Development with SAP PLM Thrifty and Thriving The Devils Own Luck Radio Replies Vol. 3 The Swimmers Workout Handbook Max Performer Weir & Abrahams Imaging Atlas of Human Anatomy Brewed in Canada Cry Havoc The Sirens! Mouses First Snow Be a Husky Not a Douche Why Should Anyone Work Here? Into the Sound Country 100 Large-Print Crossword Puzzles Maisys First Colours The Book with a Hole The Rise and Fall of the Dinosaurs Eccentric Wealth Pipers Reading Log: My First 200 Books (Gatst) Rebooting India Dancing after Hours Soap Opera Animal Soaps Essentials of Clinical Geriatrics, Eighth Edition A Sea of Glass Star Wars Even More Crochet The Rise and Decline of the British Motor Industry Shaftesbury Recollections Kids Make Music, Babies Make Music, Too! Integrating Multiculturalism into the Curriculum Novel CA(II) Complex The Key Of Dreams Hello Numbers! What Can You Do? Differential Diagnosis Pocketbook 360 Degrees Industrial Design Digital Learning Architectures of Participation Washington - Territory to Statehood Good Practice Students Book Vampires Do Exist Sgt. Reckless The Higher Powers of Mind and Spirit Ecological Poetics; Or, Wallace Stevenss Birds Super Memory - Super Student Rising Young Poets Barking up the Right Tree Mathematics for the Analysis of Algorithms Muslims and Citizens Estuary Restoration and Maintenance The League of Extraordinarily Funny Women The Dark Side of Disney The Hidden History of the JFK Assassination Physics Demonstrations Five Weeks in the Amazon The Economics of Discontent London's Afternoon Teas City Maps Obuasi Ghana Children's Furniture Projects Porsche 944 (83 - 89) Resilience in Palliative Care The Burst Of Thunder In Your Ear Brazil and La Plata Legend of Holy Women, A Easy Letter Tracing Book For Kids Just A Girl Who Loves Dad Human Purpose & the Universal Pursuit of Ecstasy The First Time I Saw You The World Mystery Metallic Ornaments of the New York Indians The Tao of Bada Bing! Season of the Sorceress Laboratory Science with Space Data Psych Up or Psych Out Creation Myths of the World [2 volumes]	cc/2021-04/en_middle_0086.json.gz/line1797190
__label__cc	0.681203	0.318797	For students › Health, safety and wellbeing › Providing health support Health support planning process Identify health support needs Develop and implement health support Observing health conditions Reviewing care plans and agreements Communication and consultation Risk minimisation strategies Post-incident and near miss management Complex or invasive health Confidentiality and consent Health impact on attendance and engagement Health impact on learning Aboriginal cultural context statement Disability context statement Information on how education and care services support children and young people with health needs. This information is regularly reviewed and updated. To make sure you have the most current information and forms, access them from this page. Children and young people recovering from an illness Education and care services cannot support children and young people who are ill or recovering from an illness. Education and care services need children and young people to have stable health and clear support plans. Children or young people who recently contracted an illness, are infectious or need rest and recuperation must stay home. Children and young people with physical, personal and mental health care needs Education and care services can safely support children and young people with physical health, personal care and mental health, where there are agreed and planned support strategies. Education and care service must follow 3 stages to anticipate, plan and manage health support: develop and implement observation and review. Health support planning must include: post-incident and near-miss management. There are many ways health support needs in education and care services can be identified, and many people that may identify this. How do you identify health support needs? On enrolment, education and care services should ask if a child or young person has any physical, mental or personal health care needs. Parents or guardians can provide education and care with the following: health profile (DOC 123KB) to give a summary of health support needs for their child or young person health care plan completed by a treating health professional health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) (education and care staff can also start these). A health support need may also be identified when: the parent or guardian says there is a support need but there is no health care plan a medical incident has occurred in the education and care service there is a change in health or support needs planning for excursions and camps there is increasing non-attendance. Who can identify health support needs? Health support needs can be identified by any person who has responsibility of care for the child or young person, including: the child or young person treating health professional education staff (including leadership, educators, support staff, student support services). A health care plan, completed by a treating health professional, is not needed to develop strategies to support a child or young person with health needs in education and care. The site leader must arrange a meeting with the child or young person, their parent or guardian, and relevant staff to discuss and develop health support and risk minimisation strategies. This must be done as soon as a need is identified. Where there’s a delay between identifying the health need and developing a plan, the education and care service will support the child or young person to attend. Health needs can be managed with standard first aid, for example calling an ambulance. This must be communicated to the child and young person and their parent or guardian. Health support agreement and safety and risk management plan The health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) are developed together by the child or young person (where possible), parent or guardian and education and care staff. If health support needs are identified but there’s no health care plan, a health support agreement and safety and risk management plan must be completed. In preschool, family day care and OSHC services a health support agreement and safety and risk management plan must be completed for all children and young people with health support needs. In schools, it’s recommended that a health support agreement and safety and risk management plan is completed for children and young people with health support needs. Strategies developed and documented in the agreement and plan must be agreed on by everyone involved. Discussions must include any risk minimisation strategies to implement to support the child or young person’s safety during attendance. Document control for care plans and agreements Original copies of care plans and agreements can be photocopied or scanned. Care plans should be colour copied. Complete the document control for care plans and support agreements (DOC 155KB) to record the number and location of all copies of the care plans and agreements. Replace forms in all locations when they are reviewed and updated. Old versions of care plans and agreements must be removed. This is to make sure only the current plan is being used. Old versions can be destroyed or kept in the child or young person’s file. Guide to planning health support Use the guide to planning health support (DOC 89KB) for help to complete the health support agreement and safety and risk management plan. Health support folders Children and young people with complex or multiple health conditions may have a health support folder. The folder contains copies of all health care plans, management plans, first aid, medication agreements and other health support information. The folder remains with the child or young person at all times and can be used by education and care, respite and out of school hours care staff. Use the health support plan folder cover (DOC 193KB) and health support plan folder guide (DOC 95KB) when making a folder. Managing health in education and care For information on specific health concerns go to managing health support in education and care. For children and young people with complex physical or mental health go to complex or invasive health. Funding for health support Education and care services can apply for funding for health support if extra support is needed for the child or young person to access and participate in preschool or school. The education and care service will need to provide evidence of the functional needs and adjustments. Go to inclusive education support program. Observation needs vary depending on the condition (go to managing health in education and care for specific health conditions). Observation may include: the child or young person having 1 on 1 nursing support to monitor their health constantly while they attend education and care services the child or young person having intermittent support and monitoring for the health needs, by a nurse or health support officer education and care staff completing observation logs or other plans identifying signs of changing needs or that show health is deteriorating. Health care plans include the date of next review. A review date is not an expiry date. If a review date has passed, the care plan can still be used until an updated plan is received. Contact the parent or guardian for an updated plan. How often you review health care plans depends on the condition and is determined by the treating health professional. Go to managing health in education and care for health conditions. At a minimum, the plan should be reviewed and updated when: symptoms increase there’s been a medical emergency related to that health condition day to day needs change. Education and care staff must consult and review the health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) in each of these circumstances: when the health care plan has been reviewed and updated as soon as possible after a medical emergency incident at the education and care service before the child or young person goes on camps or excursions or onsite special events (for example class parties, cultural days, fetes, sports or swimming events, incursions) where the safety and risk management plan has not addressed risk minimisation strategies for these activities when there’s a new medical diagnosis. Regular and timely communication helps achieve the best outcomes for children and young people with health support needs. Communicate regularly with: other education staff the parent or guardian. Do not assume their needs are the same as others with the same condition. Recognise needs may change to day to day or month to month. You can identify known symptoms, triggers, risk minimisation strategies and cultural, spiritual and language needs by communicating early. You can them make sure they’re clearly documented in the health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB). General communication strategies General communication strategies include: involving the child or young person in conversations about their health needs wherever possible letting parents or guardians know when there’s a change in support, for example when the usual support person is absent and there will be a different support person reminding staff of their duty of care and role in training for and responding to a medical emergency or incident promoting awareness of specific health conditions, and safe medication management in education and care services to parents or guardians and the wider school community giving regular reminders of the department’s process to manage medical emergencies. Go to managing health in education and care for communication strategies for specific health conditions. Education and care services must provide a safe environment and supervision to allow all children and young people to take part in and benefit from their educational experiences. Where a child or young person attending an education and care service has a known personal, physical or mental health condition, everyone’s responsible for minimising their risk. Risk minimisation strategies are documented in a safety and risk management plan (DOC 143KB). The off-site safety and risk management plan (DOC 134KB) can be used to record risk minimisation strategies for camps and excursions if they haven’t been included in the safety and risk management plan. Risk minimisation strategies should be considered for all in-school and out-of-school settings including: during classroom activities between classes and other breaks in canteens during recess and lunch before and after schools on camps and excursion home based care environments. Go to managing health in education and care for risk minimisation strategies for specific health conditions. Every education and care service must plan for a medical emergency incident. Include the response to a medical emergency in the emergency management plan. This should include: coordination and responsibilities of staff location of first aid kits and emergency medications what will happen during situations such as swimming, excursions, camps, out of school hours care and on other special occasions who will follow up incidents training and updates for education and care staff including emergency response training exercises. Education and care services undertake emergency response training from time to time to measure the response to a medical emergency across various locations and scenarios. Emergency response training should: include scenarios such as emergencies during an excursion, special event or school camp include scenarios specific to a child or young person’s health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) include as many education and care staff as possible, including out of school hours care, temporary staff, canteen and kitchen staff, sports staff and volunteers measure the time taken to get a first aid kit and emergency medication and administer first aid (be across various locations including the on-site location furthest from a first aid kit or emergency medication) measure the time taken for emergency services to arrive on location (including discussion with local emergency services providers to determine best and worst case scenarios for arrival) encourage improvements and updates to individual health support agreements and the local emergency plan for the response a medical emergency or incident where delays are identified. An emergency incident or a near-miss incident involving a child or young person can be traumatic for the child or young person involved, staff, parents, peers and other people who witnessed the incident. Post-incident debrief Education and care services should offer a post-incident debrief to everyone involved, with post-incident counselling available on an individual basis. Department staff can access the Employee Assistance Program for confidential face-to-face or phone counselling sessions at any time. First aid kit and emergency medication Restock the first aid kit and emergency medications as soon as possible. Care and support plans Where the child or young person has an existing health care plan, encourage the parent or guardian to review this with the treating health professional. You must review and update an existing health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) with the parent or guardian. Post-incident or near-miss management must include a review of all aspects of the emergency response process to manage a medical emergency. The review will identify any emergency response actions for improvement. Medication incidents All medication incidents and near-miss events must be reported on the incident and response management system (IRMS). They must also be documented on the medication advice form and forwarded to the parent or guardian as soon as possible after the event. Keep a copy in the child or young person’s file. Reporting incidents and near miss All medical incidents that require medical treatment and all near miss medication administration incidents must be reported on the incident and response management system (IRMS) within 24 hours of the event. Education and care staff are required to provide first aid measures following any care plan or support agreement and contacting emergency services if required. A health professional will complete an individual first aid plan (DOC 134KB) where the response isn’t standard first aid for that health condition. For information on standard first aid response for each health conditions go to managing health in education and care. Education and care services must have at least 1 designated first aider trained in HLTAID004 Emergency First Aid Response in an Education and Care Setting in attendance at all times. This person must be immediately available to administer first aid and emergency response medication. For more information go to the first aid intranet page and the first aid and infection control standard or contact Work Health and Safety unit education.whs [at] sa.gov.au. Go to medication management to safely manage medication in education and care services. You must follow standard precautions for the control and prevention of the spread of infection, and follow instructions from health authorities. No child or young person should be treated differently. You must not compromise the confidentiality and respect for the child or young person where they have a known infectious disease. Go to infection control and disease prevention for more information including standard precautions and exclusion periods. Develop an environmental exposure plan (DOC 142KB), with the parent or guardian, for children and young people that need modified support to manage environmental conditions. We’re committed to making sure children and young people with complex or invasive health needs can attend and be engaged in education. We do not expect education and care staff to provide complex or invasive health support. Where children and young people have complex or invasive physical or mental health or a disability, make a referral to the: Registered Nurse Delegation of Care Program (RNDCP) Health Education Interface (HEI). AAP, RNDCP and HEI do not replace existing health services but work in partnership with the child or young person, parent or guardians, education and care services and other health professionals to support the child or young person’s attendance and engagement in education. How to access support for complex or invasive health Where a child needs complex or invasive physical, personal or mental health support a WCHN Disability Services referral form is needed. The referral is completed by the education or care service and parent or guardian and gives consent for AAP, RNDCP or HEI to get information about the child or young person’s health and medical needs. Where it’s unclear if a child or young person meets the criteria for these services, the education and care service, parent or guardian can contact a referral coordinator by phone 8159 9400 or email Health.WCHNDisabilityServices [at] sa.gov.au. Assessment for complex or invasive health After accepting the referral, a health professional from AAP, RNDCP or HEI will contact the education and care service and parent or guardian to complete an assessment. The assessment includes visits to the education and care service and home, and meetings with health professionals that work with the child or young person. The assessment determines the level of support, model of care and resources to support the child or young person in education and care. Level of support complex or invasive health The Department for Communities and Social Inclusion (DCSI) Direct Health Support of People with Disability Guideline (PDF, 364KB) describes the 3 levels of health support given to people with a disability as: Level 1: no health support needs Level 2: health support that needs a health care plan developed by a treating health professional. See health care plans. Level 3: health support that needs a comprehensive health plan developed by a Registered Nurse (RN). Level 3 health plan AAP or RNDCP may develop a level 3 health plan where the person supporting the child or young person needs skills outside of the standard training for their role. Where a Level 3 health plan is in place an RN will train, assess and staff. AAP, RNDCP and HEI staff Resources are allocated to the child or young person depending on the level of support needed and the complexity of their health. This may include a Registered Nurse, Enrolled Nurse, Health Support Officer or further training and support for education and care staff. Registered Nurses, Enrolled Nurses and Health Support Officers are employees of the Department for Health and Wellbeing. There is a Memorandum of Administrative Arrangement between the Minister for Education and the Women’s and Children’s Health Network for AAP and HEI to give support in education and care services. There any many external providers that can support children and young people requiring health support in education and care. Support can include face-to-face consultancy service, online training, and awareness packages. See health support services and programs for information on services and programs. Education and care staff must maintain confidentiality of all health care information for children and young people in their care. Health information cannot be released without the permission of the parent or guardian or the child or young person where possible. Any information sharing must meet the information sharing guidelines (PDF, 14MB). Go to the information sharing guidelines for promoting safety and wellbeing procedure for more information. Education and care staff Duty of care is the responsibility to avoid acts or omissions that could potentially injure or harm others. Education and care staff must anticipate risks for children and young people and take care to prevent them coming to harm. Harm includes both physical and emotional harm. Consider what precautions the education and care service could reasonably be expected to take to prevent harm. Ask: Was the risk identified? What is the degree of harm that may occur? Did the education and care service know, or should they have known, about the risk? Where a health support need is identified, education and care services must help develop a health support agreement (DOC 131KB) and maintain open and ongoing communication with the child or young person where possible and their parent or guardian. Go to the duty of care policy (PDF, 648KB) for more information. Parents or guardians Parents or guardians have a duty of care to give correct health information for their child or young person. Education and care services do not need a full medical history for all children and young people. They only need information that will safely support the child or young person in the education and care service. Where health supports are needed, parents or guardians must: get a health care plan completed by a health professional help develop a health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB) keep open and ongoing communication with the education and care service. Check managing health in education and care to see if you need a health care plan. Poorly or unmanaged physical and mental health can affect a child or young person’s ability to attend and be positively engaged in education. A large amount of school absenteeism is because of chronic illness. Up to 35% of school absences are attributed to asthma-related symptoms (Moonie et al, 2006), but other conditions such as diabetes, cerebral palsy, epilepsy, cystic fibrosis and musculoskeletal disorders also impact attendance and cognitive functioning. A study on chronic illness and developmental vulnerability at school (PDF, 665KB) shows children and young people with a chronic illness have a 20%–35% increased risk of being developmentally vulnerable, with greater disengagement from school. The National Mental Health Commission reports children and young people with major depressive disorder have highest average number of days absent from school per year, followed by anxiety, conduct disorder and ADHD. Children and young people with ADHD are 3 times more likely to repeat a year level, and almost 3 times more likely to drop out of school before completing their secondary schooling. There is an increasing number of children and young people affected by medical emergencies such as anaphylaxis, seizures and asthma attacks. ASCIA (PDF, 738KB) reports hospital admissions for anaphylaxis have increased 4 fold in the last 20 years. Asthma Australia reports South Australian children have the highest hospitalisation rate across Australia. Children and young people with physical and mental health conditions require extra supports for meaningful engagement in their education. Health can impact how children and young people learn. Some health conditions are life-long and require consistent strategies for support, others are unpredictable. Health conditions can impact learning in the following ways: poor attendance or non-attendance inability to concentrate and pay attention inability to retain information lack of stamina and physical limitations difficulty handling time pressures and multiple tasks difficulty interacting with others side effects of some medications can include hyperactivity, irritability, aggression, drowsiness, dizziness, memory problems, problems concentrating and mood swings. Refer managing health in education and care for specific health conditions and how they impact a child or young person’s learning. Australian Aboriginal culture is the oldest living culture in the world, yet Aboriginal people currently experience the poorest health and education outcomes when compared to non-Aboriginal Australians. [The National Aboriginal and Torres Strait Islander Social Survey 2014-2015 shows poor education and literacy are linked to poor health status.] The cumulative effects of forced removal of Aboriginal children, poverty, exposure to violence, historical and transgenerational trauma, the ongoing effects of past and present systemic racism, culturally unsafe and discriminatory services are all major contributors to the disparities in Aboriginal education outcomes. To achieve the best Aboriginal education outcomes, education and care services have a responsibility to provide a culturally safe environment allowing Aboriginal children and families to draw strength in their identity, community and culture. Aboriginal children are born into strong kinship structures where roles and responsibilities are integral and woven into the social fabric of Aboriginal societies. The primary caregiver for Aboriginal children is not always the parent or guardian. Education and care staff should consider engaging members of the extended family in the absence of parent or guardians where appropriate. Education and care staff can secure positive long term education and wellbeing outcomes for our Aboriginal children and young people by making well informed decisions in consultation with families, based on cultural considerations. Health support agreements (DOC 131KB) must be developed in partnership with parents or guardians. The opportunity to identify cultural needs is paramount. Education and care staff should be aware that parents or guardians may request the input of Aboriginal Community Education Officers (ACEOs) or Aboriginal Health Workers (AHW) in the development of their child’s health support agreement. The use of an Aboriginal languages interpreter or translator (EDi login required) (PDF 191KB) should also be considered. The Department for Education acknowledge and give thanks to the Women’s and Children’s Health Network Aboriginal Focus Group for their time and commitment to developing this Aboriginal cultural context statement for the health support planning procedure. Note: The term ‘Aboriginal’ is used to refer to people who identify as Aboriginal, Torres Strait Islanders, or both Aboriginal and Torres Strait Islander. This is done because the people indigenous to South Australia are Aboriginal and we respect that many Aboriginal people prefer the term ‘Aboriginal’. We also acknowledge and respect that many Aboriginal South Australians prefer to be known by their specific language group(s). What is disability? From the Disability Discrimination Act 1992, disability is broadly summarised to include loss of bodily function, damage to bodily function, disease or illness, and disorders of thought processes, emotions, judgement or behaviour. The Disability Standards for Education 2005 (PDF, 214KB) apply to all children and young people with a disability. They support the child or young person’s right to apply for enrolment in their local school and to provide adjustments to allow for changing needs over time. Disability in education The 2018 Enrolment Census of South Australian Government schools reports the number of full time equivalent students with a verified disability was over 16,000. 93.7% of students with disability in state education attend mainstream schools (mainstream class, special class or special unit) and 6.3% attend a special school. Vulnerability in health Children and young people with disability generally have more health needs than those without disability. Some common conditions affecting children and young people with disability are gait abnormalities, flexibility, strength, and balance problems, eye disease, untreated tooth decay, blocked ear canals, and hearing issues. Children and young people with disability may not present with typical signs or symptoms when they are unwell. They may have differences in the way they express pain and distress, respond to medications and behave when feeling sick. The Australian Early Development Census (AEDC) names five domains as predictors of health and wellbeing: language and cognitive skills Having a disability increases the chance of being vulnerable in more than one domain. The opportunity to understand health conditions for students with disability and the way they impact on learning is one of the ways we can value people with disabilities and work towards their wellbeing and longevity. We support the development of culturally respectful health support planning in education and care services. We consider the political, cultural, spiritual, emotional, environmental, structural, economic and biological factors impacting the wellbeing of all children and young people. Health support agreements (DOC 131KB) are completed in consultation with parent or guardians. We make sure they understand the content and underlying values in the Australian context. They have the opportunity to discuss their cultural perspective and needs. The English as an Additional Language or Dialect (EALD) (EDi login required) program supports children and young people from culturally and linguistically diverse backgrounds, and provides access to interpreter services and Community Liaison Officers (CLOs). The Preschool Bilingual program may assist preschools to access interpreter services to support children and their families from culturally and linguistically diverse backgrounds. Family members and friends should not be used as interpreters. Go to health support training for links to training providers for specific health conditions and professional development opportunities. Each health condition has information of specific training requirements identified on the webpage. Go to managing health in education and care. Provide safe and healthy work environments. Take all reasonable measures to eliminate risk of harm. Provide access to first aid training. Provide a process to plan for and provide health support that will enable all children and young people to have equitable and safe access to education and care services. Provide opportunities for collaboration in the development of health support processes that involves parent/guardians and health professionals. Site leaders (includes principals, directors, Family Day Care and Respite Care Program leaders) Assurance that staff and families are aware of and follow the Department for Education health support planning procedures. Ensure appropriate health support provision to enable all children and young people to participate in and benefit from their educational experience including the allocation of trained staff and specific duties related to the required level of support and supervision. Ensure all staff complete and are up-to-date with an appropriate level of first aid training i.e. HLTAID004 Emergency First Aid Response in and Education and Care Setting for designated first aiders. Ensure relevant staff are able to access specialised training to support individual children with health support needs. Ensure the development and rehearsal of a medical emergency response plan. Ensure all medications are stored appropriately, securely and are readily accessible (refer medication management). Ensure communication strategies are implemented. Ensure risk minimisation strategies are implemented. Support a range of curriculum access options for children and young people requiring health support (ie distance, hospital school). Ensure all relevant education and care staff, including out of school hours care and temporary staff, canteen/kitchen staff, sports staff and volunteers are informed of emergency response and management strategies for medical incidents. Facilitate post-incident support (eg counselling) for any person affected by a medical emergency incident (staff, children or young people, peers, parents or parent/guardians). Education and care staff (includes teachers, support staff, volunteers) Have completed, and are up-to-date with first aid training and have completed additional training as required. Know the education and care service general first aid and emergency response procedures, participate in emergency response rehearsals and understand their role in responding to a medical emergency. Participate in the development of health support agreements (DOC 131KB) and safety and risk management plans (DOC 143KB) for children and young people in their care. Support children and young people to become independent in the management of their health (in line with their age, stage of development and capabilities). Plan ahead in consultation with parent/guardians of the child or young person with health support needs for high-risk curricular activities and all extracurricular activities such as excursions, camps, swimming and aquatics, class celebrations. Regular communication with parent/guardians of children and young people in their care with health support needs, including changes to behaviour and management of the health condition. Raise awareness about health conditions and the role others can play in minimising risk and contributing to the safety of their peers. Identify and manage incidents of bullying of children and young people with health support needs. Complete an IRMS report for any medical incident or near-miss (if required). Educate the child or young person about their health condition (ie how to recognise and describe symptoms, who to alert if they have concerns). Inform the education and care service of their child or young person’s health support needs. Obtain a care plan from the treating health professional as required. Participate in the development and regular review of the child or young person’s health support agreement (DOC 131KB) and safety and risk management plan (DOC 143KB). Provide the education and care service with: a copy of the care plan, action plan and/or medication agreement (where required) all medications or equipment that are current, clearly labelled and not expired (where required). Replace the child or young person’s medication or equipment needed, before the expiry date or when used. Immediately inform the education and care service on changes to the medical condition or management where this impacts on attendance, engagement or where additional health support needs are required, provide an updated plan if necessary. Notify of any changes to emergency contact details. Work with staff and their child or young person (if appropriate) to develop strategies to minimise risks and identify roles and responsibilities of staff and families and arrangements for camps and excursions. Assist staff in planning ahead for curricular and extracurricular activities such as excursions, camps, swimming and aquatics, class celebrations. Child and young person (where age appropriate) Notify another person (education and care staff, peer) when there are concerns about their health status. Avoid exposure to known triggers (where these are identified). Participate in development and review of the health support agreement (DOC 127KB) (if required). Where identified to be able to self-administer medication participate in the completion of a carrying and/or self-administration of medication decision making tool (DOC 160KB) in consultation with parent/guardian and education and care staff. Take responsibility (where appropriate) for their medication, including administration, storage, and safety. Health support agreement HSP120 Health support agreement (DOC 127KB) HSP121 Safety and risk management plan (DOC 130KB) HSP122 Offsite safety and risk management plan (DOC 134KB) HSP125 Guide to planning health support (DOC 87KB) HSP124 Individual first aid plan (DOC 134KB) First aid and infection control standard (staff login required) Incident and emergency management HSP157 Medication advice form Emergency management plan (staff login required) Incident and response management system (IRMS) (staff login required) Planning and management tools HSP123 Environmental exposure plan (DOC 142KB) HSP126 Health support plan folder cover (DOC 127KB) HSP127 Health support plan folder guide (DOC 135KB) HSP130 Document control for health care plans and support agreements (DOC 122KB) HSP128 Health profile (DOC 126KB) WCHN Disability Services referral form (DOC 284KB) Disability and Complex Needs Team Email: education.health [at] sa.gov.au On the department intranet (staff login required) First Aid (staff log in required) English as an Additional Language or Dialect (EALD) Programs Access Assistant Program and RN Delegation of Care Program, Disability Services WCHN	cc/2021-04/en_middle_0086.json.gz/line1797192
__label__cc	0.740976	0.259024	Epiroc - Mining Equipment We provide automated solutions that increase utilization and productivity in the mining and infrastructure industry. Data driven decisions Expedite the flow of information between assets and systems to the right place at the right time. Connecting assets, systems and people Share actionable insights, making incremental improvements to maximize productivity. Optimizing through automation Connect the unconnected for a smarter, integrated operation that increases efficiency. Discover how 6th Sense improves your operations 6th Sense is how we utilize collected insights to optimize your technology, value chain and employees -using automation, process and system integration. Give your connected operation an extra sense by enabling it to instantly share critical information, synchronizing resources and coordinating a response in real time. 6th Sense – Smart. Safe. Seamless. Increase accuracy and safety with automated machine functions. We have customized certain products by automating functions such as adding drill rods or changing drill bits. Features such as automatic leveling and drill stop protection are also integrated to maintain precision and safety. A new relationship between operator and machine with teleremote control. Platforms like our Rig Control System (RCS) enable machines to be operated remotely with a control panel that monitors local sensors and cameras. The operator can be located away from hazardous areas in the safety and comfort of a control room. Connectivity and automation to increase equipment productivity. We can now enable the integration of smart connected machines, programmed to complete for example, a precise drilling sequence. Machine sensors will alert the control room if there is an obstacle or the intervention of an operator is required. Without the normal constraints of staff schedules, this allows for extended machine uptime, reducing the wear and tear associated with a manual operation. Turn data into decision-making insights. Data is at the heart of an efficient operation, which is why we offer a variety of software options to collect and analyze operational data. For example, we have a telematics solution that gathers, compares and shares equipment data to help you target improvement areas. Our real-time situational awareness software tracks everything from equipment to employees, whether you are locating the nearest pump to refuel a machine or to verify that all personnel have reached a designated safety area in an emergency. Automated machine systems Maximize machine uptime with a scalable implementation plan. Working together, we can create a step-by-step plan, tailored for an automation solution and information management system that is based on your situation and optimization targets. Unlock production gains with interoperability. As part of our commitment to develop technology and innovation for the future, we have extended our interoperability platform with open and agnostic solutions for integrating equipment, processes and systems. Our APIs have pre-defined interfaces that allows your data to be collected and converted into actionable insights. Automation and information management in underground operations Automation and information management in surface operations Explore some of our automation solutions BenchREMOTE - Remote operator station BenchREMOTE Scooptram Automation Regular Pit Viper autonomous drills Epiroc Pit Viper Autonomous Drills in Peñasquito, Mexico Increased safety and productivity are two of the many benefits Goldcorp has experienced since switching from manual drills to Epiroc autonomous drills. Epiroc operated under the trademark "Atlas Copco" prior to January 1, 2018. Dynamic Tunneling Package This is how Sweden's oldest mine is to be automated A better working environment, increased safety and greater productivity are three benefits that Boliden Garpenberg has gained through the help of remote-controlled drills Looking for a revolution? The Hollinger mine in Canada is where it all happens. This is an open pit gold mine located in downtown Timmins, a city with a population of 45 000 in the province of Ontario. This site is part of Newmont Goldcorp Porcupine’s operations in the area. Once the remaining gold has been recovered, this mine will be transformed into a public park. But for now, it is a gold mine in full operation and center stage for the latest innovation in surface drilling automation. All clear in the automation zone Barrick’s Hemlo Mine goes deep with teleremote and automation – teleremote autonomous mining is helping Barrick Gold Corporation reach a deeper section of its Hemlo mine in Canada. Powered by automation Autonomous drilling is here! Safety on the benches Radomiro Tomic mine introduces remote control Insight on underground trends Tomorrow’s underground mines will be more remote with orebodies that are difﬁcult to reach and consequently more dangerous to excavate.	cc/2021-04/en_middle_0086.json.gz/line1797195

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