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NCT02553460
29:63:cancer,67:98:cancer,,157:179:cancer
Patient has newly diagnosed acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia with ≥25% blasts in the bone marrow (M3), with or without extramedullary disease
3
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NCT02453373
1:24:chronic_disease
Ventricular tachycardia
3
[ "Ventricular", "tachycardia" ]
[ 2, 2 ]
NCT02359864
19:44:treatment
Patient is taking anti-epileptic medication
3
[ "Patient", "is", "taking", "anti-epileptic", "medication" ]
[ 0, 0, 0, 1, 1 ]
NCT02495168
,23:33:treatment
for 30 days after the study drug discontinuation
3
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[ 0, 0, 0, 0, 0, 1, 1, 0 ]
NCT02402660
11:18:chronic_disease
recurring uveitis
3
[ "recurring", "uveitis" ]
[ 0, 2 ]
NCT02075671
8:28:treatment,
Use of systemic antibiotics within 1 month prior to Visit 1
3
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NCT02075671
8:25:treatment,
Use of topical retinoids (on the face) within 1 month prior to Visit 1
3
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NCT02474927
1:11:chronic_disease
Leukopenia
3
[ "Leukopenia" ]
[ 2 ]
NCT01827384
5:18:treatment,20:32:treatment,37:50:treatment,,,102:114:treatment,118:129:treatment
Any prior therapy, radiotherapy, or major surgery must have been completed >= 3 weeks (> 6 weeks for nitrosoureas or mitomycin C) or 5 half-lives of the agent (whichever is shorter) prior to enrollment on protocol
3
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NCT03070535
14:28:chronic_disease,32:52:chronic_disease,63:69:treatment,71:87:treatment,89:108:treatment,127:133:treatment
Diagnosis of hyperlipidemia or hypertriglyceridemia requiring statin, bile acid resins, fibrate medications, and/or high dose niacin
3
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NCT01858168
58:64:treatment,66:83:treatment,85:106:treatment,108:127:treatment
Concurrent use of the following classes of inhibitors of CYP3A4: azole antifungals, macrolide antibiotics, protease inhibitors
3
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NCT02143726
25:38:chronic_disease
Child Pugh Class B or C liver disease
3
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[ 0, 0, 0, 0, 0, 0, 2, 2 ]
NCT02481310
52:77:chronic_disease,89:114:chronic_disease,137:148:chronic_disease,162:186:chronic_disease,188:203:chronic_disease,208:229:chronic_disease,
Patients who have evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months
3
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NCT01835626
157:160:cancer
All lesions that the investigator proposes to follow as target lesions during the course of the study must have previously been histologically confirmed as BCC
3
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NCT02053792
42:62:allergy_name
subjects who have previously completed a CSL-sponsored rIX-FP study
3
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NCT02503722
16:25:treatment
Placement of a pacemaker for control of rhythm
3
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[ 0, 0, 0, 1, 0, 0, 0, 0 ]
NCT02167009
15:32:treatment
Refractory to medical treatment
3
[ "Refractory", "to", "medical", "treatment" ]
[ 0, 0, 1, 1 ]
NCT03051516
18:30:chronic_disease,39:56:cancer,50:56:cancer,58:66:cancer,68:75:cancer,77:83:cancer,85:91:cancer,96:107:cancer,113:133:cancer
Prior history of invasive HPV-related anogenital cancer (cervical, vaginal, vulvar, penile, or anal cancer), or oropharyngeal cancer (base of tongue, tonsil); prior cancer at other sites (including most of oral cavity) or larynx are not exclusions
3
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NCT02633163
25:47:treatment
Comorbidities requiring corticosteroid therapy
3
[ "Comorbidities", "requiring", "corticosteroid", "therapy" ]
[ 0, 0, 1, 1 ]
NCT02101944
1:14:chronic_disease,,
Hypercalcemia: serum calcium > 11.5 mg/dL
3
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NCT02382549
41:57:cancer
There has been no evident growth of any brain metastasis since the most recent treatment
3
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NCT02553642
1:8:treatment,12:28:treatment,34:61:treatment,107:125:chronic_disease
Inhaled or topical steroids, and adrenal replacement steroid doses are permitted in the absence of active autoimmune disease
3
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NCT02095678
37:40:treatment
Patients with contraindications for MRI due to embedded foreign metallic objects
3
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NCT01433965
23:35:cancer,,,,108:118:cancer,120:155:cancer,160:201:cancer
Disease free of other malignancies beside the AML or MDS for ≥ 2 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma in situ of the cervix or breast
3
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NCT02493530
1:17:treatment
Organ transplant recipients
3
[ "Organ", "transplant", "recipients" ]
[ 1, 1, 0 ]
NCT02549937
,,,54:65:chronic_disease,,
Urine protein > 2+; Patients discovered to have ≥ 1+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate < 1 g of protein in 24-hour urine
3
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NCT03086473
44:65:chronic_disease,78:102:chronic_disease,104:124:chronic_disease,132:152:chronic_disease,164:189:chronic_disease,196:206:treatment
Exclusions are major congenital anomalies, major cardiac defects (other than patent ductus arteriosus, patent foramen ovale, small atrial septal defect, and small ventricular septal defect), and intubation in the delivery room
3
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NCT02489539
1:20:chronic_disease,,
Renal insufficiency defined as creatinine > 2.5 mg/dL
3
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NCT02699697
,,,,,110:118:treatment
Pain score of at least 5 on a scale of 0 - 10 within a week of enrollment OR pain score < 5 with >= 60 mg of morphine (or equivalent) per day
3
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NCT02826681
1:14:chronic_disease,22:45:chronic_disease,49:60:chronic_disease
Secondary RLS due to neurological conditions or head trauma
3
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NCT03087903
45:61:allergy_name
Documented hypersensitivity reaction to any product with GSE (see complete list in Appendix 1)
3
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NCT02516969
,,115:129:treatment
have a positive pregnancy test (reproductive age should use effective birth control during study if randomized to SBRT treatment arm)
3
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NCT01169155
15:33:chronic_disease
Subject has a hearing impairment
3
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[ 0, 0, 0, 2, 2 ]
NCT02091141
73:76:chronic_disease,91:99:chronic_disease,,,,,,,,,277:289:chronic_disease,351:379:treatment
Presence of any of the following conditions, which are risk factors for RVO: Uncontrolled glaucoma with intraocular pressure >21 millimetres of mercury (mm Hg); Serum cholesterol ≥Grade 2; Hypertriglyceridemia ≥Grade 2; Hyperglycemia (fasting) ≥Grade 2; Grade ≥2 uncontrolled hypertension (participants with a history of hypertension controlled with anti-hypertensive medication to Grade </=1 are eligible)
3
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NCT02332369
1:16:chronic_disease
Corneal disease
3
[ "Corneal", "disease" ]
[ 2, 2 ]
NCT01849146
14:34:chronic_disease,77:93:chronic_disease,107:131:chronic_disease,133:157:chronic_disease,159:177:chronic_disease,182:201:chronic_disease
uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements, are ineligible
3
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NCT02172651
18:30:treatment,34:43:treatment,,98:111:treatment
The last dose of chemotherapy or radiation must have been administered at least 4 weeks prior to liver surgery
3
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NCT02725177
14:27:chronic_disease,
Severe other organ disease felt to be likely to lead to death within the next six months
3
[ "Severe", "other", "organ", "disease", "felt", "to", "be", "likely", "to", "lead", "to", "death", "within", "the", "next", "six", "months" ]
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NCT02398773
24:37:chronic_disease
Patient must NOT be in liver failure as judged by the patient's physician
3
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NCT02226159
,40:49:treatment
More than one cervical level requiring injection
3
[ "More", "than", "one", "cervical", "level", "requiring", "injection" ]
[ 0, 0, 0, 0, 0, 0, 1 ]
NCT01950351
39:69:cancer,
Histologically confirmed diagnosis of adenocarcinoma of the prostate within one year of study entry
3
[ "Histologically", "confirmed", "diagnosis", "of", "adenocarcinoma", "of", "the", "prostate", "within", "one", "year", "of", "study", "entry" ]
[ 0, 0, 0, 0, 3, 3, 3, 3, 0, 0, 0, 0, 0, 0 ]
NCT03162731
24:41:treatment,,57:67:treatment,84:108:treatment
syndrome that requires systemic steroids (> 10 mg daily prednisone equivalents) or immunosuppressive agents
3
[ "syndrome", "that", "requires", "systemic", "steroids", "(", ">", "10", "mg", "daily", "prednisone", "equivalents", ")", "or", "immunosuppressive", "agents" ]
[ 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 1 ]
NCT01787682
17:20:chronic_disease
No diagnosis of CHF
3
[ "No", "diagnosis", "of", "CHF" ]
[ 0, 0, 0, 2 ]
NCT02495935
1:11:chronic_disease,
Strabismus less than 10 prism diopters
3
[ "Strabismus", "less", "than", "10", "prism", "diopters" ]
[ 2, 0, 0, 0, 0, 0 ]
NCT02913430
36:56:treatment
Washout of 2 weeks is required for aromatase inhibitors
3
[ "Washout", "of", "2", "weeks", "is", "required", "for", "aromatase", "inhibitors" ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 1 ]
NCT01829958
14:31:chronic_disease
Uncontrolled diabetes mellitus
3
[ "Uncontrolled", "diabetes", "mellitus" ]
[ 0, 2, 2 ]
NCT02237183
74:101:treatment,109:115:chronic_disease,116:122:chronic_disease,126:149:cancer,
Participants must not be currently receiving or have previously received thiazolidinedione treatment unless sputum atypia or endobronchial dysplasia are documented again after thiazolidinedione treatment and within 12 months of entry
3
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NCT02357784
5:8:chronic_disease
has QTc prolongation
3
[ "has", "QTc", "prolongation" ]
[ 0, 2, 0 ]
NCT02451423
28:59:treatment
Subjects who have received prior intravesical chemotherapy are allowed
3
[ "Subjects", "who", "have", "received", "prior", "intravesical", "chemotherapy", "are", "allowed" ]
[ 0, 0, 0, 0, 1, 1, 1, 0, 0 ]
NCT02213913
1:19:treatment
Prior pomalidomide exposure
3
[ "Prior", "pomalidomide", "exposure" ]
[ 1, 1, 0 ]
NCT01261728
9:29:chronic_disease,,
Ongoing cardiac dysrhythmias of NCI CTCAE Version 4.0 grade ≥ 2
3
[ "Ongoing", "cardiac", "dysrhythmias", "of", "NCI", "CTCAE", "Version", "4.0", "grade", "≥", "2" ]
[ 0, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
NCT02365467
26:44:chronic_disease,46:58:chronic_disease,71:88:treatment
Subject has a history of bleeding diathesis, coagulopathy, or refuses blood transfusion
3
[ "Subject", "has", "a", "history", "of", "bleeding", "diathesis", ",", "coagulopathy", ",", "or", "refuses", "blood", "transfusion" ]
[ 0, 0, 0, 0, 0, 2, 2, 0, 2, 0, 0, 0, 1, 1 ]
NCT01184547
1:20:chronic_disease
Renal insufficiency
3
[ "Renal", "insufficiency" ]
[ 2, 2 ]
NCT02217709
1:27:treatment,,
Post-radical prostatectomy: Any PSA >= 0.4 ng/ml
3
[ "Post-radical", "prostatectomy", ":", "Any", "PSA", ">", "=", "0.4", "ng/ml" ]
[ 1, 1, 0, 0, 0, 0, 0, 0, 0 ]
NCT00670358
4:25:chronic_disease,
No myocardial infarction within the past 6 months
3
[ "No", "myocardial", "infarction", "within", "the", "past", "6", "months" ]
[ 0, 2, 2, 0, 0, 0, 0, 0 ]
NCT01925131
55:71:chronic_disease
Patients must not have a history of chronic or active hepatitis B or C infection
3
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[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 2, 2, 2, 2, 0 ]
NCT02965638
1:20:chronic_disease,84:96:chronic_disease,,132:144:chronic_disease,175:199:chronic_disease,201:224:chronic_disease,226:239:chronic_disease,257:266:treatment,269:293:chronic_disease,302:308:chronic_disease,,,349:370:chronic_disease,,,414:435:chronic_disease,490:524:chronic_disease
Maternal conditions that may alter fetal hemodynamic, including moderate to severe hypertension requiring medication in pregnancy, preeclampsia, major or unrepaired maternal congenital heart disease, obstructive sleep apnea, severe asthma (requiring daily treatment), restrictive lung disease, severe anemia (hemoglobin less than 8 g/dL), maternal chronic renal disease (creatinine greater than 1.2 mg/dL), known placental abnormality (complete placenta previa, accrete, or percreta), and antiphospholipid antibody syndrome
3
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NCT02481765
40:48:chronic_disease,50:60:chronic_disease,62:67:chronic_disease,69:83:chronic_disease,85:90:chronic_disease,92:110:chronic_disease,112:121:chronic_disease,123:142:chronic_disease,146:152:cancer
Previous or current medical history of epilepsy, neurologic, heart, endocrinologic, renal, chronic infectious, metabolic, psychiatric disease or cancer
3
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NCT01421095
28:35:cancer
Estrogen receptor positive cancers
3
[ "Estrogen", "receptor", "positive", "cancers" ]
[ 0, 0, 0, 3 ]
NCT02565199
1:29:chronic_disease,,
Impaired cognitive abilities (score lesser than 75th percentile on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS))
3
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NCT02195232
35:68:treatment,
Receiving or scheduled to receive first or second line chemotherapy (within 30 days of registration)
3
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NCT02873598
,,96:109:treatment,
A negative urine or serum pregnancy test must be obtained within 14 days prior to the start of study therapy in all women of child-bearing potential
3
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NCT02207439
77:101:chronic_disease,103:127:chronic_disease,132:151:chronic_disease
Uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness/social situations that would limit compliance with study requirements
3
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NCT02544880
29:53:cancer,55:72:cancer,77:95:cancer
Recurrent or second primary HNSCC of the nasopharynx, paranasal sinuses, or cervical esophagus
3
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NCT01620216
1:12:treatment,71:81:treatment,,145:157:chronic_disease
hydroxyurea is allowed prior to enrollment and after the start of the study drug for the control of peripheral leukemic blasts in subjects with leukocytosis per physician discretion
3
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NCT00909909
,25:45:cancer
No more than 9 positive axillary lymph nodes
3
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[ 0, 0, 0, 0, 0, 3, 3, 3 ]
NCT03179397
1:17:chronic_disease
Systemic disease that could increase the operative risk or confound the outcome
3
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NCT02422641
1:13:chronic_disease,17:45:chronic_disease,55:75:chronic_disease,118:124:treatment,140:149:treatment
Uncontrolled or progressive systemic disease or other concurrent condition which in the Investigator's opinion makes HD-MTX an undesirable treatment option for the patient or would jeopardize compliance
3
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NCT03140527
14:16:chronic_disease,26:33:treatment,34:50:treatment,126:147:chronic_disease,151:167:chronic_disease,168:193:chronic_disease
diagnosis of CF with the F508del/F508del genotype on record, along with clinical findings consistent with CF such as chronic sinopulmonary disease or gastrointestinal/nutritional abnormalities
3
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NCT02833792
12:18:cancer,,76:81:cancer,85:108:cancer
History of cancer within the past 5 years, with the exception of localized basal or squamous cell carcinoma
3
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NCT02670837
1:39:chronic_disease
Junctional Epidermolysis Bullosa (JEB) with at least one wound
3
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[ 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]
NCT02088554
16:38:chronic_disease
Patient has an anatomical abnormality which would increase surgical risk of morbidity or mortality
3
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NCT02519322
15:24:cancer,26:33:cancer,35:40:cancer,42:47:cancer,52:77:cancer
patients with cutaneous, mucosal, acral, ocular or unknown primary melanomas are eligible for enrollment
3
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NCT03088033
1:23:chronic_disease,
Advanced heart failure defined as one or more
3
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[ 2, 2, 2, 0, 0, 0, 0, 0 ]
NCT02823665
12:24:chronic_disease
history of dyslipidemia
3
[ "history", "of", "dyslipidemia" ]
[ 0, 0, 2 ]
NCT02914171
18:53:chronic_disease
Individuals with preoperative ventricular arrhythmia requiring medical management
3
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[ 0, 0, 2, 2, 2, 0, 0, 0 ]
NCT01737502
37:52:treatment,54:62:treatment,64:75:treatment,77:119:treatment
Unable to discontinue use of potent cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inhibitors/inducers
3
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NCT01842399
100:115:chronic_disease,128:142:treatment,173:194:chronic_disease,,223:229:chronic_disease,237:246:treatment
Unable to perform treadmill testing due to reasons such as orthopedic problems, moderate to severe aortic stenosis as found on echocardiogram at ScreeningVisit, history of myocardial infarction in the last three months or angina (under treatment)
3
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NCT01662466
1:15:chronic_disease
Hyperlipidemia
3
[ "Hyperlipidemia" ]
[ 2 ]
NCT01940757
24:37:chronic_disease,,
Laboratory evidence of liver disease (alanine aminotransferase [ALT] greater than 1.25-times the upper reference limit)
3
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NCT02227199
32:51:treatment
Patients with prior receipt of brentuximab vedotin
3
[ "Patients", "with", "prior", "receipt", "of", "brentuximab", "vedotin" ]
[ 0, 0, 0, 0, 0, 1, 1 ]
NCT03035773
19:44:cancer
Diagnosed with in situ or metastatic breast
3
[ "Diagnosed", "with", "in", "situ", "or", "metastatic", "breast" ]
[ 0, 0, 0, 3, 3, 3, 3 ]
NCT03011801
13:46:chronic_disease
Presence of cervical or uterine abnormalities
3
[ "Presence", "of", "cervical", "or", "uterine", "abnormalities" ]
[ 0, 0, 2, 2, 2, 2 ]
NCT01600040
45:75:treatment,79:99:treatment,104:119:treatment,131:143:treatment
Have undergone simple, modified radical, or radical abdominal hysterectomy or vaginal hysterectomy and lymphadenectomy by open or laparoscopic assisted technique
3
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NCT02446886
67:69:chronic_disease,96:108:chronic_disease,110:121:chronic_disease,123:132:chronic_disease,134:141:chronic_disease,143:148:chronic_disease,150:163:chronic_disease,165:174:chronic_disease,176:190:chronic_disease,202:227:chronic_disease,230:246:chronic_disease,248:267:chronic_disease,301:310:chronic_disease
Subject currently has a significant medical condition (other than MS) including the following: neurological, psychiatric, metabolic, hepatic, renal, hematological, pulmonary, cardiovascular (including uncontrolled hypertension), gastrointestinal, urological disorder, or central nervous system (CNS) infection that would pose a risk to the subject if they were to participate in the study or that might confound the results of the study
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NCT02192398
17:28:treatment,50:77:treatment,88:107:treatment,114:123:treatment,129:138:treatment,142:169:treatment,176:186:treatment,188:199:treatment,201:210:treatment
Subjects are on medications that are ligands for alpha2-adrenergic receptors including antipsychotic drugs (e.g. clozapine) and tricyclic or tetracyclic antidepressants (e.g. imipramine, mirtazapine, mianserin)
3
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NCT02487082
1:21:chronic_disease
Peptic ulcer disease
3
[ "Peptic", "ulcer", "disease" ]
[ 2, 2, 2 ]
NCT01660607
1:26:cancer
Myelodysplastic syndromes
3
[ "Myelodysplastic", "syndromes" ]
[ 3, 3 ]
NCT00909909
81:93:treatment
No evidence of suspicious microcalcifications in the breast before the start of radiotherapy
3
[ "No", "evidence", "of", "suspicious", "microcalcifications", "in", "the", "breast", "before", "the", "start", "of", "radiotherapy" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1 ]
NCT02479230
32:40:treatment,60:69:treatment,73:83:chronic_disease
for subjects who are receiving warfarin for prophylaxis or treatment of thrombosis, INR values should be carefully monitored while patients are on study
3
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NCT02420977
,36:51:treatment
At least 10 days after most recent prostate biopsy
3
[ "At", "least", "10", "days", "after", "most", "recent", "prostate", "biopsy" ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 1 ]
NCT02987491
1:14:chronic_disease,,
Hyperglycemia (fasting glucose >126 mg/dl)
3
[ "Hyperglycemia", "(", "fasting", "glucose", ">", "126", "mg/dl", ")" ]
[ 2, 0, 0, 0, 0, 0, 0, 0 ]
NCT02100722
11:36:treatment
Requiring renal replacement therapy
3
[ "Requiring", "renal", "replacement", "therapy" ]
[ 0, 1, 1, 1 ]
NCT02347111
24:37:allergy_name
Contra-indication to a class III AAD
3
[ "Contra-indication", "to", "a", "class", "III", "AAD" ]
[ 0, 0, 0, 4, 4, 4 ]
NCT00985205
,,44:52:treatment
Deep 2nd and/or 3rd degree burns requiring grafting
3
[ "Deep", "2nd", "and/or", "3rd", "degree", "burns", "requiring", "grafting" ]
[ 0, 0, 0, 0, 0, 0, 0, 1 ]
NCT03114319
1:40:chronic_disease
Insufficient hepatic and renal function
3
[ "Insufficient", "hepatic", "and", "renal", "function" ]
[ 2, 2, 2, 2, 2 ]
NCT02391402
11:34:treatment,46:54:treatment,,,186:195:treatment,284:300:treatment,319:343:treatment,347:356:treatment,
Initiated psychotropic medication, including Prazosin, within 4 weeks or changed dosage within 2 weeks prior to the first assessment, as this would make it difficult to determine which treatment contributed to change in the CABA condition; additionally, started or changed dosage of sleep medication or low dosages of tricyclic antidepressant or trazodone for pain or sleep within 1 week prior to the first assessment
3
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NCT02582827
,,,,,183:193:treatment
Women of childbearing potential and women < 12 months since onset of menopause must have a negative serum pregnancy test (ß-hCG) within 24 hours prior to the first administration of study drug
3
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NCT02469389
1:21:chronic_disease
Cognitive impairment
3
[ "Cognitive", "impairment" ]
[ 2, 2 ]
NCT02132598
12:28:treatment
History of organ transplant
3
[ "History", "of", "organ", "transplant" ]
[ 0, 0, 1, 1 ]