Datasets:
Sebasdi
/
hERG_blockers_v02

Dataset card Data Studio Files
xet
Community
1
id
stringlengths
36
36
solution
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2 values
drug
stringlengths
9
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problem
stringlengths
59
245
da3fe171-f47e-4ada-be1d-07f08006512b
Yes
Oc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1
Does the specified drug exhibit hERG blocking activity? Oc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1
32b9a1c3-608d-4a73-8330-364f0ddc9baf
Yes
Fc1ccc(C(OCC[NH+]2CC[NH+](CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1
Determine if the following medication inhibits hERG potassium channels. Fc1ccc(C(OCC[NH+]2CC[NH+](CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1
c06cb085-6169-4109-8290-50c89b82c44e
Yes
O=C1NCN(c2ccccc2)C12CC[NH+](CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2
Does the specified drug exhibit hERG blocking activity? O=C1NCN(c2ccccc2)C12CC[NH+](CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2
bd269bf2-234e-4027-a2fe-91200da1016b
Yes
Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1
Does this drug act as a hERG channel blocker? Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1
8e8a310c-943f-45e7-bd00-09551c878481
Yes
CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccc4nonc4c3)CC1)O2
Determine if the following medication inhibits hERG potassium channels. CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccc4nonc4c3)CC1)O2
c9c4e702-9c66-4ac6-ad21-f628bb8f8dd2
Yes
C[NH+](CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1
Check whether the given drug blocks hERG channels. C[NH+](CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1
fe4be18c-b2d8-4d7b-b5ea-d3fd89c1483c
Yes
CN(C)Cc1cc2cc(Cl)ccc2n1-c1ccc(F)cc1
Does the specified drug exhibit hERG blocking activity? CN(C)Cc1cc2cc(Cl)ccc2n1-c1ccc(F)cc1
f9ef1514-4f93-4143-b20b-4201737b8b80
Yes
C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@]5(C)[C@H]6CC[C@]7(C)[C@@H](C8=CC(=O)OC8)CC[C@]7(O)[C@@H]6CC[C@@H]5C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O
Check whether the given drug blocks hERG channels. C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@]5(C)[C@H]6CC[C@]7(C)[C@@H](C8=CC(=O)OC8)CC[C@]7(O)[C@@H]6CC[C@@H]5C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O
d75b035e-86a0-4587-abaf-50a112f60262
Yes
C[NH+]1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1
Is the drug in question known to block hERG channels? C[NH+]1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1
d7323f99-c285-42dc-8c92-7d9a49340270
Yes
CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1
Check whether the given drug blocks hERG channels. CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1
14826258-58a3-46a4-9005-adbc9bdcb7f5
Yes
O=C1NCCN1CC[NH+]1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1
Does the specified drug exhibit hERG blocking activity? O=C1NCCN1CC[NH+]1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1
0fd96d5d-27af-41cc-b656-bf1a5295e04d
Yes
Cc1ccc(O)c([C@@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
Determine if the following medication inhibits hERG potassium channels. Cc1ccc(O)c([C@@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
cca625e9-1e9f-4f96-a123-08854bd92138
Yes
CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2
Is the drug provided capable of blocking hERG channels? CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2
9ead2f2f-3ec3-460e-850f-83aba1bf3f00
Yes
C[C@@H]1O[C@@H](O[C@@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@@H](O)C[C@]5(C)[C@H](C6=CC(=O)OC6)CC[C@]5(O)[C@@H]4CC[C@@]3(O)C2)[C@H](O)[C@H](O)[C@H]1O
Does the drug listed below function as a hERG inhibitor? C[C@@H]1O[C@@H](O[C@@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@@H](O)C[C@]5(C)[C@H](C6=CC(=O)OC6)CC[C@]5(O)[C@@H]4CC[C@@]3(O)C2)[C@H](O)[C@H](O)[C@H]1O
6e6f937c-422a-47f8-a5ea-e7da22c6c769
Yes
Cc1cccc(C)c1NC(=O)C[NH+]1CC[NH+](CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
Is the drug provided capable of blocking hERG channels? Cc1cccc(C)c1NC(=O)C[NH+]1CC[NH+](CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
54d3cdb6-f16e-449e-9136-0b2a62f718f0
Yes
COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCOc2ccc(F)cc2)C[C@@H]1OC
Verify if this drug has hERG blocking properties. COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCOc2ccc(F)cc2)C[C@@H]1OC
f9c2db68-d013-4e6c-b30d-e078c7efb9f7
Yes
COc1ccc(CC[NH+](C)CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(OC)c(OC)c2)cc1OC
Does the drug listed below function as a hERG inhibitor? COc1ccc(CC[NH+](C)CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(OC)c(OC)c2)cc1OC
b820b823-6d56-4c8c-85e0-df636e180324
Yes
O=C1NCCN1CCN1CCC([C@@H]2CN(c3ccc(F)cc3)c3ccccc32)CC1
Is the drug provided capable of blocking hERG channels? O=C1NCCN1CCN1CCC([C@@H]2CN(c3ccc(F)cc3)c3ccccc32)CC1
e4a312a4-72c9-4721-a914-86434c69c339
Yes
N#Cc1ccc(Cn2cncc2C[NH+](CCCc2ccccc2)[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
Does the drug listed below function as a hERG inhibitor? N#Cc1ccc(Cn2cncc2C[NH+](CCCc2ccccc2)[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
71715166-29a8-4683-8abc-10d7e5c0d882
Yes
CCCCCCC[NH+](CC)CCC[C@@H](O)c1ccc(NS(C)(=O)=O)cc1
Is the drug in question known to block hERG channels? CCCCCCC[NH+](CC)CCC[C@@H](O)c1ccc(NS(C)(=O)=O)cc1
d8437f6d-18d9-46ad-8293-c2b3c3263074
Yes
Fc1ccc(Cn2c(NC3CC[NH2+]CC3)nc3ccccc32)cc1
Is the drug in question known to block hERG channels? Fc1ccc(Cn2c(NC3CC[NH2+]CC3)nc3ccccc32)cc1
2f484767-0330-44a4-a448-2dbda2cb336b
Yes
O=C(CCC[NH+]1CC=C([N+]2=c3ccccc3=NC2=O)CC1)c1ccc(F)cc1
Does the drug listed below function as a hERG inhibitor? O=C(CCC[NH+]1CC=C([N+]2=c3ccccc3=NC2=O)CC1)c1ccc(F)cc1
22503b50-3391-4c3f-b7c4-7831ecc08eb5
Yes
CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
Is this pharmaceutical compound a blocker of the hERG ion channel? CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
fbd7d5e3-06f4-4d26-b204-99dbe0b2230a
Yes
CCCCNCC[C@H](O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
Is the drug provided capable of blocking hERG channels? CCCCNCC[C@H](O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
ce577555-8b6b-4138-a0f8-a4a4053362a1
Yes
CCCCNCCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
Does the specified drug exhibit hERG blocking activity? CCCCNCCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
77bdb4e1-bfee-42d3-b4ef-ccfe50b13580
Yes
c1ccc(-c2[nH]c3ccccc3c2C2CCN(c3ccccc3)CC2)cc1
Is this pharmaceutical compound a blocker of the hERG ion channel? c1ccc(-c2[nH]c3ccccc3c2C2CCN(c3ccccc3)CC2)cc1
f320a398-1f10-44a1-b119-71b2ff012a12
Yes
O=C1NCCN1CCN1CCC(c2cn(-c3ccccc3)c3ccc(Cl)cc23)CC1
Does the drug listed below function as a hERG inhibitor? O=C1NCCN1CCN1CCC(c2cn(-c3ccccc3)c3ccc(Cl)cc23)CC1
5db8200c-fa63-4005-bb97-47d2fc8a17d7
Yes
CSc1ccc2c(c1)N(CC[C@H]1CCCC[NH+]1C)c1ccccc1S2
Verify if this drug has hERG blocking properties. CSc1ccc2c(c1)N(CC[C@H]1CCCC[NH+]1C)c1ccccc1S2
bce3b3b4-7d7c-4782-8ad3-424e891a307a
Yes
O=C(c1ccc(F)cc1)C1CC[NH+](CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Does the specified drug exhibit hERG blocking activity? O=C(c1ccc(F)cc1)C1CC[NH+](CCn2c(=O)[nH]c3ccccc3c2=O)CC1
71c57194-5a36-41f3-a25e-5de1d5941928
Yes
COc1ccc(CC[NH+](C)CCC[C@@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
Is the drug provided capable of blocking hERG channels? COc1ccc(CC[NH+](C)CCC[C@@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
24cf282a-a434-4fb0-ba5d-03c04039d318
Yes
CC1=NC2=[N+](CCC[C@H]2O)C(=O)[C@@H]1CC[NH+]1CCC(c2noc3cc(F)ccc23)CC1
Assess if the following substance is a hERG blocker. CC1=NC2=[N+](CCC[C@H]2O)C(=O)[C@@H]1CC[NH+]1CCC(c2noc3cc(F)ccc23)CC1
f1bf81db-5489-48f3-a073-b23bb231d31b
Yes
Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[NH+](C)CC1
Verify if this drug has hERG blocking properties. Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[NH+](C)CC1
ccb5df79-d540-4f70-9f77-d0f251cbacf6
Yes
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
Verify if this drug has hERG blocking properties. CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
4c2b1ebc-5589-40ca-a879-754aec54246e
Yes
CCCC[NH+](Cc1cncn1Cc1ccc(C#N)cc1)[C@H]1CCN(Cc2ccccc2)C1=O
Is the drug provided capable of blocking hERG channels? CCCC[NH+](Cc1cncn1Cc1ccc(C#N)cc1)[C@H]1CCN(Cc2ccccc2)C1=O
6ce89258-db9b-48c0-86aa-97e8e2869028
Yes
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
Verify if this drug has hERG blocking properties. COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
ac5bf3a1-11aa-4b50-b7d1-94510f28b1d7
Yes
CC[NH+](CC)CCCN(c1ccccc1)C1Cc2ccccc2C1
Verify if this drug has hERG blocking properties. CC[NH+](CC)CCCN(c1ccccc1)C1Cc2ccccc2C1
810c2005-b0ee-43e6-88d2-d0bea0c218f5
Yes
CC[NH+](CC)CCCN(CC(=O)N(C1CCCCC1)C1CCCCC1)C(=O)c1ccc([N+](=O)[O-])cc1
Does the drug listed below function as a hERG inhibitor? CC[NH+](CC)CCCN(CC(=O)N(C1CCCCC1)C1CCCCC1)C(=O)c1ccc([N+](=O)[O-])cc1
51c3798c-4bfb-48e0-b337-b2170699e846
Yes
CN1[C@H](C[C@@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1.CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2
Is the drug in question known to block hERG channels? CN1[C@H](C[C@@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1.CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2
31a9c8e4-2990-4540-8996-45227788ab64
Yes
O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
Does this drug act as a hERG channel blocker? O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
f0bbe376-e49c-4e7d-9f29-6abe441eb688
Yes
CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1
Check whether the given drug blocks hERG channels. CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1
78694e2c-940b-4ee2-8184-fcbc232078b8
Yes
N#Cc1ccc(Cn2cncc2C[NH2+][C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
Assess if the following substance is a hERG blocker. N#Cc1ccc(Cn2cncc2C[NH2+][C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
1e7c8b8f-7471-4e43-890a-9a414623806d
Yes
C[C@H](CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21
Determine if the following medication inhibits hERG potassium channels. C[C@H](CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21
a78ef3e7-ffc9-40fd-9f30-1fa0e2a5d505
Yes
N#Cc1ccc(Cn2cncc2C[NH+](CCC[NH3+])[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
Assess if the following substance is a hERG blocker. N#Cc1ccc(Cn2cncc2C[NH+](CCC[NH3+])[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
71a4e841-0b6e-4516-bc69-93b3853ebae8
Yes
N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1
Is this pharmaceutical compound a blocker of the hERG ion channel? N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1
c9d712cc-74f1-41f2-aee5-918e838a0549
Yes
COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12
Does this drug act as a hERG channel blocker? COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12
55caff79-6e20-4826-82f8-39219094a407
Yes
C[NH+]1[C@H]2CC[C@@H]1CC(OC(=O)[C@@H](CO)c1ccccc1)C2
Is the drug provided capable of blocking hERG channels? C[NH+]1[C@H]2CC[C@@H]1CC(OC(=O)[C@@H](CO)c1ccccc1)C2
43c5be0e-bea1-4285-bb58-1e91d266ea3c
Yes
COc1cc2nc(N3CCN(C(=O)[C@H]4COc5ccccc5O4)CC3)nc(N)c2cc1OC
Does this drug act as a hERG channel blocker? COc1cc2nc(N3CCN(C(=O)[C@H]4COc5ccccc5O4)CC3)nc(N)c2cc1OC
be8726d1-de4b-48af-be03-ff8b207e3f22
Yes
C[C@H](Cc1ccccc1)[NH2+]CCC(c1ccccc1)c1ccccc1
Verify if this drug has hERG blocking properties. C[C@H](Cc1ccccc1)[NH2+]CCC(c1ccccc1)c1ccccc1
64598990-5141-422d-b8f1-162252a0a5a8
Yes
CN1CCN(CCCN(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)[C@@H]2C[C@@H](c3ccc4c(c3)[C@H](N)NO4)[C@@H]3C[C@H]32)CC1
Does the drug listed below function as a hERG inhibitor? CN1CCN(CCCN(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)[C@@H]2C[C@@H](c3ccc4c(c3)[C@H](N)NO4)[C@@H]3C[C@H]32)CC1
813c1145-3fb3-4b53-a6ab-fd75af2584ec
Yes
[NH3+]CC[C@@H](O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
Determine if the following medication inhibits hERG potassium channels. [NH3+]CC[C@@H](O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
798c9c5a-7961-46bb-ad08-c2f72a1105e1
Yes
C[C@H](CN1c2ccccc2Sc2ccc(C#N)cc21)C[NH+](C)C
Assess if the following substance is a hERG blocker. C[C@H](CN1c2ccccc2Sc2ccc(C#N)cc21)C[NH+](C)C
691734a1-3303-44ab-bb60-cb022be2501a
Yes
C[C@@H](CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21
Check whether the given drug blocks hERG channels. C[C@@H](CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21
0abef6da-1da3-4ead-9b1f-5d533aad1ec0
Yes
N#Cc1ccc(Cn2cncc2C[NH+](Cc2cccnc2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1
Does the specified drug exhibit hERG blocking activity? N#Cc1ccc(Cn2cncc2C[NH+](Cc2cccnc2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1
9a51a204-6995-4369-b08e-cf4607327843
Yes
CN(C)CC[C@H](c1ccc(Br)cc1)c1ccccn1
Does this drug act as a hERG channel blocker? CN(C)CC[C@H](c1ccc(Br)cc1)c1ccccn1
4e86fe2b-9cff-43a6-8ca4-ad62b67c27c9
Yes
CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1
Does the drug listed below function as a hERG inhibitor? CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1
678c3013-abfa-4150-b3b8-47319c2ada21
Yes
CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1
Does the specified drug exhibit hERG blocking activity? CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1
cb9afa5e-4bc7-4db7-9bef-21f42d51d247
Yes
CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21
Determine if the following medication inhibits hERG potassium channels. CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21
74ccba22-07b5-4136-a844-f9537dad5f43
Yes
CC[C@H]1[C@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]45C[C@@H]([C@H]2[C@H]5O)N3[C@@H]1O
Check whether the given drug blocks hERG channels. CC[C@H]1[C@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]45C[C@@H]([C@H]2[C@H]5O)N3[C@@H]1O
1dc427b8-458a-4286-8328-2061de0719a4
Yes
O=C1CCC(c2ccc(Nc3ccncc3)cc2)=NN1
Verify if this drug has hERG blocking properties. O=C1CCC(c2ccc(Nc3ccncc3)cc2)=NN1
d4d276d9-f106-4464-b288-1b3524be781a
Yes
C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
Determine if the following medication inhibits hERG potassium channels. C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
8167a540-d9b9-4498-8f78-ecb3d209cf2d
Yes
Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1
Does the specified drug exhibit hERG blocking activity? Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1
48f2b7d5-c99a-49e2-a408-d26aae1fe189
Yes
N#Cc1ccc(Cn2cncc2C[NH+](CC[NH+]2CC[NH2+]CC2)[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
Is the drug provided capable of blocking hERG channels? N#Cc1ccc(Cn2cncc2C[NH+](CC[NH+]2CC[NH2+]CC2)[C@@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1
d389b2aa-5a77-47c0-bbfb-289191bf1d41
Yes
CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1
Check whether the given drug blocks hERG channels. CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1
5460580a-e05a-4b61-a2c1-2697b16b19b6
Yes
CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(Cc3ccsc3)CC1=O)C2
Verify if this drug has hERG blocking properties. CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(Cc3ccsc3)CC1=O)C2
711299a1-c7d7-4a77-8436-3520daffb462
Yes
CCOC(=O)[C@@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1[NH+]2C
Is the drug in question known to block hERG channels? CCOC(=O)[C@@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1[NH+]2C
c073da23-ad71-4f11-8304-b91cae22893a
Yes
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCC[C@@H]2O
Does the drug listed below function as a hERG inhibitor? Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCC[C@@H]2O
2a726328-dc6c-4b45-94a3-bd4c4f57b6a5
Yes
CCCN(CCC)CCc1cccc2c1CC(=O)N2.Cl
Does the drug listed below function as a hERG inhibitor? CCCN(CCC)CCc1cccc2c1CC(=O)N2.Cl
e2943578-e142-437d-ab74-edbb9d8c38c2
Yes
CN(CCCN)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1
Assess if the following substance is a hERG blocker. CN(CCCN)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1
1fb59e61-5660-4b9d-86f6-07ac3998c97b
Yes
C[NH2+]CCCN1c2ccccc2CCc2ccccc21
Determine if the following medication inhibits hERG potassium channels. C[NH2+]CCCN1c2ccccc2CCc2ccccc21
6de08d96-d003-4df8-81c0-65df7c606901
Yes
O=C1NC[C@@H](c2ccccc2)C12CCN([C@H]1CCCC[C@@H]1c1ccccc1)CC2
Assess if the following substance is a hERG blocker. O=C1NC[C@@H](c2ccccc2)C12CCN([C@H]1CCCC[C@@H]1c1ccccc1)CC2
0d506dcf-6622-45c7-b752-6c2595a2453c
Yes
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(Cl)c(Cl)cc2o1
Is the drug in question known to block hERG channels? O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(Cl)c(Cl)cc2o1
ac0ac847-bfe9-4cdd-bc5c-8980a60a18f8
Yes
COCC(=O)O[C@@]1(CC[NH+](C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
Verify if this drug has hERG blocking properties. COCC(=O)O[C@@]1(CC[NH+](C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
3532b951-1d39-4ec4-8500-18de0f3fdeee
Yes
Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O
Is this pharmaceutical compound a blocker of the hERG ion channel? Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O
2bc06984-b4e4-4e8e-8e62-620946aba457
Yes
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C(=O)CN(C)C)CC1
Does the drug listed below function as a hERG inhibitor? COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C(=O)CN(C)C)CC1
9534fd07-94c9-480b-bbc6-f987ccd54fcd
Yes
CC(C)(C)[C@@H](N)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1
Is the drug in question known to block hERG channels? CC(C)(C)[C@@H](N)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1
b5e18ca3-4d9e-4912-b08f-62c07512628f
Yes
Fc1ccc2c([C@@H]3C[NH2+]CC[C@H]3F)c(-c3ccsc3)[nH]c2c1
Verify if this drug has hERG blocking properties. Fc1ccc2c([C@@H]3C[NH2+]CC[C@H]3F)c(-c3ccsc3)[nH]c2c1
354a7ae3-a25a-4766-aef4-812baad2e277
Yes
C[C@H](CC(c1ccccc1)c1ccccc1)[NH2+]C(C)(C)C
Does this drug act as a hERG channel blocker? C[C@H](CC(c1ccccc1)c1ccccc1)[NH2+]C(C)(C)C
deb545b7-ac15-46b8-bca0-d5d9dbb7ec20
Yes
COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC
Check whether the given drug blocks hERG channels. COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC
3d2d2b50-7be9-4d63-9104-5cfcfe88d2e5
Yes
COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)[nH]c(=N)c2cc1OC
Does the drug listed below function as a hERG inhibitor? COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)[nH]c(=N)c2cc1OC
5602baf9-c49c-4b20-8007-766c0b11c94f
Yes
Fc1ccc(-c2[nH]c3cc(F)ccc3c2[C@@H]2C[NH2+]CC[C@@H]2F)cc1
Is the drug in question known to block hERG channels? Fc1ccc(-c2[nH]c3cc(F)ccc3c2[C@@H]2C[NH2+]CC[C@@H]2F)cc1
38eda8fb-9072-492f-bec3-33a5f8763cc3
Yes
C(#Cc1cc(-c2n[nH]c3c2Cc2cc(Cn4cncn4)ccc2-3)cs1)COc1ccccc1
Is the drug provided capable of blocking hERG channels? C(#Cc1cc(-c2n[nH]c3c2Cc2cc(Cn4cncn4)ccc2-3)cs1)COc1ccccc1
58861d6e-7d6b-45d7-9602-53ca28dcfb11
Yes
CCC(=O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
Assess if the following substance is a hERG blocker. CCC(=O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
670955df-fb8a-4537-a4e4-8c04a8f25e51
Yes
COc1cc2c(cc1OC)C(=O)[C@@H](CC1CC[NH+](Cc3ccccc3)CC1)C2
Does the drug listed below function as a hERG inhibitor? COc1cc2c(cc1OC)C(=O)[C@@H](CC1CC[NH+](Cc3ccccc3)CC1)C2
a7bcb98b-986c-4755-8584-3898f07e5321
Yes
O=C1CN(CCc2ccc(F)cc2)CCN1[C@H]1CCc2cc(CN3CCC(C(F)(F)F)CC3)ccc2C1
Does the specified drug exhibit hERG blocking activity? O=C1CN(CCc2ccc(F)cc2)CCN1[C@H]1CCc2cc(CN3CCC(C(F)(F)F)CC3)ccc2C1
f2ccab7f-d069-47fa-a93e-888e6644c39d
Yes
CCOC(=O)C1=C(COCC[NH3+])NC(C)=C(C(=O)OC)[C@H]1c1ccccc1Cl
Assess if the following substance is a hERG blocker. CCOC(=O)C1=C(COCC[NH3+])NC(C)=C(C(=O)OC)[C@H]1c1ccccc1Cl
61d68156-3501-4ecd-8834-8a2741ef10e9
Yes
COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CC[NH+]2CCC[C@H]1C2
Verify if this drug has hERG blocking properties. COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CC[NH+]2CCC[C@H]1C2
03ef49d8-9709-4235-b940-abbdd19ca1d2
Yes
Clc1ccc(CO[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1
Assess if the following substance is a hERG blocker. Clc1ccc(CO[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1
72c862a0-9b59-4d6e-9c79-ce692b3c4d73
Yes
CC(C)(CN)C(=O)N1CC(c2cc(F)ccc2F)=C[C@@H]1c1ccccc1
Is the drug provided capable of blocking hERG channels? CC(C)(CN)C(=O)N1CC(c2cc(F)ccc2F)=C[C@@H]1c1ccccc1
03581b9f-c5ce-45fd-aeab-8868b066ee9b
Yes
CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
Determine if the following medication inhibits hERG potassium channels. CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
d1238dfa-46ba-475c-b86b-70286a361cf5
Yes
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Is the drug provided capable of blocking hERG channels? CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
f3ae8f62-5543-4277-910b-a438571e5fa7
Yes
CC(C)[C@@H](N)C(=O)N1CC(c2cc(F)ccc2F)=C[C@@H]1c1ccccc1
Check whether the given drug blocks hERG channels. CC(C)[C@@H](N)C(=O)N1CC(c2cc(F)ccc2F)=C[C@@H]1c1ccccc1
09d11433-fa6e-40c0-a102-298386926705
Yes
CC[C@H](OC(C)=O)C(C[C@H](C)N(C)C)(c1ccccc1)c1ccccc1
Check whether the given drug blocks hERG channels. CC[C@H](OC(C)=O)C(C[C@H](C)N(C)C)(c1ccccc1)c1ccccc1
6b1e16d3-1875-45fd-8c84-e174a88df571
Yes
CC[NH+](CC)CCC[C@@H](C)Nc1ccnc2cc(Cl)ccc12
Is this pharmaceutical compound a blocker of the hERG ion channel? CC[NH+](CC)CCC[C@@H](C)Nc1ccnc2cc(Cl)ccc12
edde17c6-59ab-4467-bf4c-060672f80887
Yes
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(Br)cc2o1
Is this pharmaceutical compound a blocker of the hERG ion channel? O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(Br)cc2o1
a6885756-9eff-4d24-8368-645e4aeeea83
Yes
C1CCC2(C1)C1C[NH+](CC3CC3)CC2C[NH+](CC2CC2)C1
Assess if the following substance is a hERG blocker. C1CCC2(C1)C1C[NH+](CC3CC3)CC2C[NH+](CC2CC2)C1
6fa7d07d-5139-441d-8101-49a326ca5e7f
Yes
Fc1ccc2c([C@@H]3C[NH2+]CC[C@@H]3F)c(C3=CNC=CC3)[nH]c2c1
Check whether the given drug blocks hERG channels. Fc1ccc2c([C@@H]3C[NH2+]CC[C@@H]3F)c(C3=CNC=CC3)[nH]c2c1
58b89a00-c8d7-4fd9-b78e-99720d83321e
Yes
COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3[C@@H](Cc3ccccc3)N1CC2
Is the drug in question known to block hERG channels? COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3[C@@H](Cc3ccccc3)N1CC2
be077029-eccf-4cf5-be3e-c942c45b0e1c
Yes
O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCC[NH2+]1
Assess if the following substance is a hERG blocker. O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCC[NH2+]1
f442f973-a5fd-4954-b5bb-977d6e0c5567
Yes
COc1cc2c(cc1OC)[C@@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2
Does this drug act as a hERG channel blocker? COc1cc2c(cc1OC)[C@@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2
fea7ea8d-3089-4364-b535-9b151f9dadae
Yes
O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12
Is the drug provided capable of blocking hERG channels? O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12