Datasets:
Sebasdi
/
hERG_blockers_v02

Dataset card Data Studio Files
xet
 Community
1
id
stringlengths
36
36
solution
stringclasses
2 values
drug
stringlengths
9
188
problem
stringlengths
59
245
6760e55a-1a62-49e6-8a51-533da5269f51
Yes
CCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C
Verify if this drug has hERG blocking properties. CCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C
c61cfff4-99f1-4945-a9e9-d383b9a704d3
Yes
O=C1CN(CCc2ccc(F)cc2)CCN1[C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1
Does this drug act as a hERG channel blocker? O=C1CN(CCc2ccc(F)cc2)CCN1[C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1
341441b9-121e-4481-a7b5-0aae27bcb3c3
Yes
COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCCCC(=O)O[C@@H]2CN3CCC2CC3)C[C@@H]1OC
Check whether the given drug blocks hERG channels. COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCCCC(=O)O[C@@H]2CN3CCC2CC3)C[C@@H]1OC
75ecd0b8-ae5c-4e58-8d4e-9c99c0f8ec0f
Yes
CN(C)C(=O)[C@@H](CO)N(C)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc(F)cc3)CC1=O)C2
Does the drug listed below function as a hERG inhibitor? CN(C)C(=O)[C@@H](CO)N(C)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc(F)cc3)CC1=O)C2
bbf5ef28-5d4c-470a-bec1-d133178f68c7
Yes
CC(C)(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2cc[n+]([O-])cc2)ccc1OC(F)F
Is the drug in question known to block hERG channels? CC(C)(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2cc[n+]([O-])cc2)ccc1OC(F)F
31f6c94a-fc43-4995-9b81-2d8881b66854
Yes
COc1cc(C(=O)N=S(=O)([O-])c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
Does the drug listed below function as a hERG inhibitor? COc1cc(C(=O)N=S(=O)([O-])c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
02294953-a314-420f-86f4-420bbfec5b21
Yes
CC(C)(O)[C@H]1C=CC([C@@H](c2cc[n+]([O-])cc2)c2ccc(OC(F)F)c(OC(F)F)c2)=CN1
Check whether the given drug blocks hERG channels. CC(C)(O)[C@H]1C=CC([C@@H](c2cc[n+]([O-])cc2)c2ccc(OC(F)F)c(OC(F)F)c2)=CN1
80eb0699-bffc-4773-a146-45192eab3de7
Yes
Cc1nc2c(=O)n(CC3(c4ccccc4)CC3)ccn2c1Br
Is this pharmaceutical compound a blocker of the hERG ion channel? Cc1nc2c(=O)n(CC3(c4ccccc4)CC3)ccn2c1Br
41226028-8aa3-4322-9e00-89f82ca225f4
Yes
CN(C)Cc1cc2cc(Cl)ccc2n1-c1ccc(F)cc1
Assess if the following substance is a hERG blocker. CN(C)Cc1cc2cc(Cl)ccc2n1-c1ccc(F)cc1
a7c7704f-bb96-4704-8e23-64a4dacd8e23
Yes
O=C([O-])COCC[NH+]1CC[NH+]([C@H](c2ccccc2)c2ccc(Cl)cc2)CC1
Does this drug act as a hERG channel blocker? O=C([O-])COCC[NH+]1CC[NH+]([C@H](c2ccccc2)c2ccc(Cl)cc2)CC1
f192fe33-a589-4f99-bc29-ceed36c5d696
Yes
CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH+](C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O
Does the drug listed below function as a hERG inhibitor? CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH+](C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O
042671a7-c1cd-48fa-b0e4-70bca22277f3
Yes
CC(C)Oc1cc([C@@H](C2=CN[C@@H](C(O)(C(F)(F)F)C(F)(F)F)S2)c2ccc[n+]([O-])c2)ccc1OC(F)F
Does this drug act as a hERG channel blocker? CC(C)Oc1cc([C@@H](C2=CN[C@@H](C(O)(C(F)(F)F)C(F)(F)F)S2)c2ccc[n+]([O-])c2)ccc1OC(F)F
cede4eb6-dd13-4d88-84dd-d9f07287054c
Yes
CCN(CC)CCOC(=O)c1ccc(N)cc1.CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
Is the drug provided capable of blocking hERG channels? CCN(CC)CCOC(=O)c1ccc(N)cc1.CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
2d9dac48-e66c-4eee-b2c1-2abb11e3789a
No
CC(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2cc[n+]([O-])cc2)ccc1OC(F)F
Is the drug provided capable of blocking hERG channels? CC(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2cc[n+]([O-])cc2)ccc1OC(F)F
cd9f3c24-17a4-4c81-8a75-b6b8d06643c1
No
CC(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2ccc[n+]([O-])c2)ccc1OC(F)F
Assess if the following substance is a hERG blocker. CC(C)Oc1cc([C@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2ccc[n+]([O-])c2)ccc1OC(F)F
3e3928d7-3f03-4481-95d1-d2864c4adf4a
No
Cc1nnc(C(C)C)n1C1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
Does the drug listed below function as a hERG inhibitor? Cc1nnc(C(C)C)n1C1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
e6b8062f-a675-4ddb-9770-710d99da0843
No
CC(C)Oc1cc([C@@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2ccc[n+]([O-])c2)ccc1OC(F)F
Is the drug provided capable of blocking hERG channels? CC(C)Oc1cc([C@@H](C2=CN[C@@H](C(C)(C)O)C=C2)c2ccc[n+]([O-])c2)ccc1OC(F)F
6eaa0740-238b-451c-aeea-3dc6d1506632
No
Cc1ccc([C@@]23CNC[C@@H]2C3)cc1
Determine if the following medication inhibits hERG potassium channels. Cc1ccc([C@@]23CNC[C@@H]2C3)cc1
319af5d2-e038-4519-b582-9b38036d1385
No
CC(=O)Nc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1
Assess if the following substance is a hERG blocker. CC(=O)Nc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1
65ca9549-d6f2-49d9-b890-9ef186cc84cf
No
CCOP(=O)(Sc1ccccc1)Sc1ccccc1
Does the specified drug exhibit hERG blocking activity? CCOP(=O)(Sc1ccccc1)Sc1ccccc1
2f9baeda-a8bb-485a-b99e-6ea58883e9f3
No
N#Cc1ccc(Cn2cncc2C[NH2+][C@@H]2CCN(C(=O)c3cccnc3N)C2=O)cc1
Check whether the given drug blocks hERG channels. N#Cc1ccc(Cn2cncc2C[NH2+][C@@H]2CCN(C(=O)c3cccnc3N)C2=O)cc1
0b5b9790-11b0-4963-9069-20c9df9011fb
No
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1c1cccc2nonc12
Check whether the given drug blocks hERG channels. COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1c1cccc2nonc12
18c138ad-b40f-47a0-b65d-717bbd38e6f8
No
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)C(=O)C1
Does this drug act as a hERG channel blocker? CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)C(=O)C1
4223ff70-493c-4e80-b3a7-121695191762
No
CC(C)Oc1cc([C@@H](C2=CCC(=O)N=C2)C2=CN[C@@H](C(C)(C)O)C=C2)ccc1OC(F)F
Is this pharmaceutical compound a blocker of the hERG ion channel? CC(C)Oc1cc([C@@H](C2=CCC(=O)N=C2)C2=CN[C@@H](C(C)(C)O)C=C2)ccc1OC(F)F
5d85646d-5316-46ad-8dbb-823d206cae08
No
CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([NH+](C)C)[C@@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@]1(C)O
Is the drug in question known to block hERG channels? CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([NH+](C)C)[C@@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@]1(C)O
00d62e7b-a002-4a02-941b-7afc5c227770
No
CC(C)(C)Oc1cc([C@H](C2=CN[C@H](C(O)(C(F)(F)F)C(F)(F)F)S2)c2cc[n+]([O-])cc2)ccc1OC(F)F
Assess if the following substance is a hERG blocker. CC(C)(C)Oc1cc([C@H](C2=CN[C@H](C(O)(C(F)(F)F)C(F)(F)F)S2)c2cc[n+]([O-])cc2)ccc1OC(F)F
a045c556-7e0c-4e2b-8532-4d63a3e8bb2e
No
O=C(c1ccc(F)cc1)c1ccc(F)cc1
Is the drug in question known to block hERG channels? O=C(c1ccc(F)cc1)c1ccc(F)cc1
04987779-e24f-4470-8fa0-9d0876743cb3
No
O=C(c1ccccc1F)c1ccccc1F
Is this pharmaceutical compound a blocker of the hERG ion channel? O=C(c1ccccc1F)c1ccccc1F
505d2e8d-9ff9-4153-b74a-a0fc28b76830
No
COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)([O-])=NC(=O)NC2CCCCC2)cc1
Does this drug act as a hERG channel blocker? COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)([O-])=NC(=O)NC2CCCCC2)cc1
9e98d8eb-54ee-42d1-a117-ab86f2a739a5
No
CCC1=C(C)CN(C(=O)NCCc2ccc(S(=O)([O-])=NC(=O)NC3CCC(C)CC3)cc2)C1=O
Does the drug listed below function as a hERG inhibitor? CCC1=C(C)CN(C(=O)NCCc2ccc(S(=O)([O-])=NC(=O)NC3CCC(C)CC3)cc2)C1=O
947359e2-e52d-4d98-8291-b985e491ec02
No
CC(C)[NH2+]C[C@H](O)c1ccc(NS(C)(=O)=O)cc1
Determine if the following medication inhibits hERG potassium channels. CC(C)[NH2+]C[C@H](O)c1ccc(NS(C)(=O)=O)cc1
cc818284-82cf-46ed-9b9c-b3d4ed501a1c
Yes
CCOC(=O)C1(c2ccccc2)CCN(C)CC1
Check whether the given drug blocks hERG channels. CCOC(=O)C1(c2ccccc2)CCN(C)CC1
9badb089-e55e-41f1-b759-8ee2256cb221
No
C[C@@H]([NH2+]C(C)(C)C)C(=O)c1cccc(Cl)c1
Assess if the following substance is a hERG blocker. C[C@@H]([NH2+]C(C)(C)C)C(=O)c1cccc(Cl)c1
445c0310-f22b-4d7d-acf3-76b38b4ad187
No
O=C(NCCN1CCOCC1)c1ccc(Cl)cc1
Verify if this drug has hERG blocking properties. O=C(NCCN1CCOCC1)c1ccc(Cl)cc1
3491cd20-936e-4c2d-9343-94650f3ae9a9
No
COc1cc2nc(N(C)CCCNC(=O)[C@H]3CCCO3)nc(C)c2cc1OC
Does the drug listed below function as a hERG inhibitor? COc1cc2nc(N(C)CCCNC(=O)[C@H]3CCCO3)nc(C)c2cc1OC
872a5fff-d507-43b7-a0b0-c8b20c2fb73c
No
Cc1cn2ccn(CC3(c4ccccc4)CC3)c(=O)c2n1
Assess if the following substance is a hERG blocker. Cc1cn2ccn(CC3(c4ccccc4)CC3)c(=O)c2n1
ae052f73-25b3-471a-baff-048e62955302
No
CN1CC(=O)N2[C@@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O
Check whether the given drug blocks hERG channels. CN1CC(=O)N2[C@@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O
0880735c-e8cd-4754-9503-29bee0f363f1
No
CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3c(c2)OCO3)C1=O
Does the specified drug exhibit hERG blocking activity? CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3c(c2)OCO3)C1=O
c478462f-d400-4e41-84db-cbc0621bdd19
No
CO[C@@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@H](O[C@@H]2C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H]([NH+](C)C)[C@H]1O
Is the drug in question known to block hERG channels? CO[C@@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@H](O[C@@H]2C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H]([NH+](C)C)[C@H]1O
7fa0b73f-6e6e-4acb-bef8-44c7994a6f3c
No
C[C@@]12CCC(=O)C=C1C=C[C@@H]1[C@H]2CC[C@]2(C)[C@@H]1CC[C@]2(O)CCC(=O)[O-]
Is this pharmaceutical compound a blocker of the hERG ion channel? C[C@@]12CCC(=O)C=C1C=C[C@@H]1[C@H]2CC[C@]2(C)[C@@H]1CC[C@]2(O)CCC(=O)[O-]
f74a466f-a7ee-45dd-8f61-c47e0017d928
No
C[C@]12CC[C@@H]3[C@@H](C=CC4=CC(=O)CC[C@@]43C)[C@H]1CC[C@@]2(O)CCC(=O)O
Check whether the given drug blocks hERG channels. C[C@]12CC[C@@H]3[C@@H](C=CC4=CC(=O)CC[C@@]43C)[C@H]1CC[C@@]2(O)CCC(=O)O
a7ad130a-4819-41f7-9ee1-349ce100df21
No
CCOc1ccccc1OCC[NH2+][C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1
Check whether the given drug blocks hERG channels. CCOc1ccccc1OCC[NH2+][C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1
6b1e335b-0a39-43f3-ac20-ffb8842423e4
No
CC1=C2[C@@H]3OC(=O)[C@@H](C)[C@@H]3[C@H](O)C[C@]2(C)C=CC1=O
Assess if the following substance is a hERG blocker. CC1=C2[C@@H]3OC(=O)[C@@H](C)[C@@H]3[C@H](O)C[C@]2(C)C=CC1=O
3b4fa853-ebf4-4786-8719-f31a8d6d2844
No
O=c1c(O)c(-c2ccc(O)cc2O)oc2cc(O)cc(O)c12
Does the drug listed below function as a hERG inhibitor? O=c1c(O)c(-c2ccc(O)cc2O)oc2cc(O)cc(O)c12
d4c779c3-0d67-4c0d-bd73-d55c53d0fdd6
No
COc1c(N2CC[NH2+][C@H](C)C2)c(F)cc2c1[N+](C1CC1)=C[C@@H](C(=O)[O-])C2=O
Is the drug provided capable of blocking hERG channels? COc1c(N2CC[NH2+][C@H](C)C2)c(F)cc2c1[N+](C1CC1)=C[C@@H](C(=O)[O-])C2=O
fdfcadb7-4157-446c-9601-1e8a500d6636
No
COc1c(N2C[C@H]3CCC[NH2+][C@H]3C2)c(F)cc2c1[N+](C1CC1)=C[C@@H](C(=O)[O-])C2=O
Does the specified drug exhibit hERG blocking activity? COc1c(N2C[C@H]3CCC[NH2+][C@H]3C2)c(F)cc2c1[N+](C1CC1)=C[C@@H](C(=O)[O-])C2=O
f317adb5-9885-49fe-86d2-0d56a419eb6a
No
COCCc1ccc(-n2cc(C3CC[NH+](CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1
Does this drug act as a hERG channel blocker? COCCc1ccc(-n2cc(C3CC[NH+](CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1
85479892-f697-4e5a-a6a2-6a307208ab28
No
CCC[C@@H](C)C1(CC)C(=O)NC(=O)NC1=O
Does the specified drug exhibit hERG blocking activity? CCC[C@@H](C)C1(CC)C(=O)NC(=O)NC1=O
cf3c7ee6-4c48-4bc2-8693-bc9bc65cb1e7
No
C[NH+]1CC[NH+]([C@@H]2c3ccccc3Nc3ccc(Cl)cc3N2O)CC1
Check whether the given drug blocks hERG channels. C[NH+]1CC[NH+]([C@@H]2c3ccccc3Nc3ccc(Cl)cc3N2O)CC1
52ebf67d-3a92-48d3-a8c1-735e0eaa110e
No
CCN(CC)CCNC(=O)c1ccc(N)cc1
Check whether the given drug blocks hERG channels. CCN(CC)CCNC(=O)c1ccc(N)cc1
867f5645-bd1a-49b4-9af8-ea79d4633b5e
No
CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH2+]C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
Is this pharmaceutical compound a blocker of the hERG ion channel? CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH2+]C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
660bbdb8-de3f-4540-86f7-75ba0641e568
No
CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@@H](C)[C@H](O[C@H]2O[C@H](C)C[C@@H]([NH+](C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@]1(C)O
Does the drug listed below function as a hERG inhibitor? CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@@H](C)[C@H](O[C@H]2O[C@H](C)C[C@@H]([NH+](C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@]1(C)O
55a0ca3c-df0e-4174-ba35-8bf1d9b4948b
No
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F
Assess if the following substance is a hERG blocker. N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F
7ba09712-be67-45e4-8df6-be3bd5ed337e
No
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
Does the drug listed below function as a hERG inhibitor? CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
d572dc67-b4a9-4a2d-bfb4-2e4041d896aa
No
Cc1cccc(C)c1NC(=O)[C@@H]1CCCCN1C
Does the drug listed below function as a hERG inhibitor? Cc1cccc(C)c1NC(=O)[C@@H]1CCCCN1C
db343ac3-2ead-47b8-92c6-74f0bed81db5
No
C[NH+]1CCc2cc3c(cc2C(=O)Cc2ccc4c(c2C1)OCO4)OCO3
Determine if the following medication inhibits hERG potassium channels. C[NH+]1CCc2cc3c(cc2C(=O)Cc2ccc4c(c2C1)OCO4)OCO3
d3f6b008-4aac-487d-858a-ba0f4be4baaa
No
COC(=O)C1=CC[C@@H]2CC[C@@H]1[NH+]2C
Determine if the following medication inhibits hERG potassium channels. COC(=O)C1=CC[C@@H]2CC[C@@H]1[NH+]2C
27303e05-0247-4a29-8940-2513f7756c2c
No
Fc1ccc(-n2cc(C3CC[NH2+]CC3)c3cc(Cl)ccc32)cc1
Verify if this drug has hERG blocking properties. Fc1ccc(-n2cc(C3CC[NH2+]CC3)c3cc(Cl)ccc32)cc1
9686cffc-0107-4d7f-afab-ab204ed572b2
No
CO/N=C1\CN(c2nc3c(cc2F)C(=O)[C@H](C(=O)O)CN3C2CC2)CC12CNC2
Does the drug listed below function as a hERG inhibitor? CO/N=C1\CN(c2nc3c(cc2F)C(=O)[C@H](C(=O)O)CN3C2CC2)CC12CNC2
47997181-188e-4fe1-b0b9-c2a7394abd83
No
CCCN[C@@H](C)C(=O)Nc1c(C)csc1C(=O)OC
Is the drug provided capable of blocking hERG channels? CCCN[C@@H](C)C(=O)Nc1c(C)csc1C(=O)OC
8d8bd12a-cc88-4f5f-ad15-6242ab292e2b
No
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Does the drug listed below function as a hERG inhibitor? COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
1721591c-8aba-4cd5-8b57-2dd4f59b29f9
No
NC[C@@H](O)COc1ccccc1C(=O)CCc1ccccc1
Does this drug act as a hERG channel blocker? NC[C@@H](O)COc1ccccc1C(=O)CCc1ccccc1
698474be-33d8-48e2-b208-7af195526ddc
No
O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1
Is this pharmaceutical compound a blocker of the hERG ion channel? O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1
60406947-6967-49e3-a6d7-057e26d883df
No
C[NH+]1CCC[C@@H]1c1cccnc1
Assess if the following substance is a hERG blocker. C[NH+]1CCC[C@@H]1c1cccnc1
df481409-2212-441e-be70-d1408a92b544
No
CCN(CC)CC(=O)Nc1c(C)cccc1C
Does the drug listed below function as a hERG inhibitor? CCN(CC)CC(=O)Nc1c(C)cccc1C
61dd35c8-a6b7-4f2c-80be-c58d659d1030
No
CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH+](C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)[C@H]([NH3+])[C@H](C)[C@@H](O)[C@]1(C)O
Is the drug provided capable of blocking hERG channels? CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([NH+](C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)[C@H]([NH3+])[C@H](C)[C@@H](O)[C@]1(C)O
4f03321a-9ee8-4a6f-bd56-98a81f9e21a1
No
COc1ccc2c(c1)c(CC(=O)[O-])c(C)n2C(=O)c1ccc(Cl)cc1
Does the specified drug exhibit hERG blocking activity? COc1ccc2c(c1)c(CC(=O)[O-])c(C)n2C(=O)c1ccc(Cl)cc1
84aab751-6e42-436e-bd16-6527282fb40c
No
CC(C)(NC(=O)c1ccc(O)cc1)C(=O)O
Check whether the given drug blocks hERG channels. CC(C)(NC(=O)c1ccc(O)cc1)C(=O)O
2500b9e8-654f-4b93-8c5e-1aa5b655e1d7
No
COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)[NH+](C)CC[C@]314
Does this drug act as a hERG channel blocker? COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)[NH+](C)CC[C@]314
19862a60-4e87-4eb6-a242-b4c0b024d01d
No
CO[C@@H]1C[C@H](O[C@H]2[C@H](C)C(=O)O[C@H](C)[C@H](C)[C@@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@@H]([NH+](C)C)[C@@H]3O)[C@H]2C)O[C@H](C)[C@H]1O
Does the specified drug exhibit hERG blocking activity? CO[C@@H]1C[C@H](O[C@H]2[C@H](C)C(=O)O[C@H](C)[C@H](C)[C@@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@@H]([NH+](C)C)[C@@H]3O)[C@H]2C)O[C@H](C)[C@H]1O
448c1f25-b850-4fd9-bd32-8da77a95a70a
No
CC(C)(O)c1ccc([C@H](O)CCC[NH+]2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Assess if the following substance is a hERG blocker. CC(C)(O)c1ccc([C@H](O)CCC[NH+]2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
d86be4dd-22ff-4f46-880e-b1e553206be7
No
CC1CCN(c2c(F)c(N)c3c4c2OC[C@@H](C)[C@@H]4C=C(C(=O)O)C3=O)CC1
Is the drug in question known to block hERG channels? CC1CCN(c2c(F)c(N)c3c4c2OC[C@@H](C)[C@@H]4C=C(C(=O)O)C3=O)CC1
b1dad601-dd98-43bd-bd20-c097f81e5529
No
O=C([O-])C1=C[N+](C2CC2)=C2C=C(N3CC[NH2+]CC3)C(F)=C[C@H]2C1=O
Is the drug provided capable of blocking hERG channels? O=C([O-])C1=C[N+](C2CC2)=C2C=C(N3CC[NH2+]CC3)C(F)=C[C@H]2C1=O
c01f8ded-c648-4530-b67d-11f37f51a298
No
CC(C)[NH2+]C[C@@H](O)COc1ccc(CC(N)=O)cc1
Does the specified drug exhibit hERG blocking activity? CC(C)[NH2+]C[C@@H](O)COc1ccc(CC(N)=O)cc1
4acaa5d0-cf36-47b9-997f-1eeaa90546c4
No
C[NH+]1CC[C@]23c4c5ccc(O)c4O[C@@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
Does the drug listed below function as a hERG inhibitor? C[NH+]1CC[C@]23c4c5ccc(O)c4O[C@@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
691f78d9-92a8-4950-896e-6f11d2571852
No
C[C@@H]1COc2c(N3CC[NH+](C)CC3)c(F)cc3c(=O)c(C(=O)[O-])cn1c23
Verify if this drug has hERG blocking properties. C[C@@H]1COc2c(N3CC[NH+](C)CC3)c(F)cc3c(=O)c(C(=O)[O-])cn1c23
66c51de3-657d-461e-af63-27d2ea04f013
No
C[N@@+]1(CC2CC2)CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
Does the drug listed below function as a hERG inhibitor? C[N@@+]1(CC2CC2)CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
aad69451-28a4-4e3e-9443-e6d65ad46d09
No
CCn1cc(C(=O)[O-])c(=O)c2cc(F)c(N3CC[NH2+][C@H](C)C3)c(F)c21
Does this drug act as a hERG channel blocker? CCn1cc(C(=O)[O-])c(=O)c2cc(F)c(N3CC[NH2+][C@H](C)C3)c(F)c21
eefa4db5-bca1-474e-b597-b9df980a87a0
No
NC(=O)N1c2ccccc2C=Cc2ccccc21
Is the drug in question known to block hERG channels? NC(=O)N1c2ccccc2C=Cc2ccccc21
0d3921a9-2a19-43f3-9662-c6c98577bd1d
No
CCC1(c2ccccc2)C(=O)NC(=O)NC1=O
Is the drug in question known to block hERG channels? CCC1(c2ccccc2)C(=O)NC(=O)NC1=O
8f99b4b8-8dd0-4d92-8cca-52562ecf664a
No
CCc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
Verify if this drug has hERG blocking properties. CCc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
c9d00b65-7ff5-435e-8fae-37d8c5bf462a
No
Nc1ccncc1
Verify if this drug has hERG blocking properties. Nc1ccncc1
8ad1243c-abb1-46d1-91d6-47864e90130b
No
C[C@H](O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
Assess if the following substance is a hERG blocker. C[C@H](O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
0e40c9d4-3906-4b14-b0ec-2a3c722b17d9
No
COC(=O)[C@H]1[C@@H](O)C[C@H]2CC[C@@H]1[NH+]2C
Verify if this drug has hERG blocking properties. COC(=O)[C@H]1[C@@H](O)C[C@H]2CC[C@@H]1[NH+]2C
14563db3-1f7e-4e69-83e1-5d7b231cb02a
No
CN/C(NCCSCc1[nH]cnc1C)=[NH+]\C#N
Does the specified drug exhibit hERG blocking activity? CN/C(NCCSCc1[nH]cnc1C)=[NH+]\C#N
a6f21638-4950-4ae4-9a25-557987db9c27
No
Cc1nnc(C(=O)NC(C)(C)C2=N/C(=C(\O)NCc3ccc(F)cc3)C(=O)C(=O)N2C)o1
Verify if this drug has hERG blocking properties. Cc1nnc(C(=O)NC(C)(C)C2=N/C(=C(\O)NCc3ccc(F)cc3)C(=O)C(=O)N2C)o1
113dad82-f12d-4ffb-93a1-ba678b06a3cb
No
C[NH+](C)CCO[C@](C)(c1ccccc1)c1ccccn1
Check whether the given drug blocks hERG channels. C[NH+](C)CCO[C@](C)(c1ccccc1)c1ccccn1
47309d2e-8f68-43bc-9b60-2c949a51ed4f
No
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
Does the drug listed below function as a hERG inhibitor? CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
637e8c74-22ac-4510-9ee5-8c8c46429ef8
No
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](C)CC[C@]314
Does this drug act as a hERG channel blocker? COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](C)CC[C@]314
847b9574-8b8e-4fcf-b48e-bc74ebebfe2d
No
CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[n-]n2)cc1)[C@H](C(=O)[O-])C(C)C
Does the specified drug exhibit hERG blocking activity? CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[n-]n2)cc1)[C@H](C(=O)[O-])C(C)C
e312abb2-bdae-4218-a028-c56af10df777
No
CCCC[C@](C)(O)C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC
Does the drug listed below function as a hERG inhibitor? CCCC[C@](C)(O)C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC
0b76e5ce-348b-44fb-a1a0-483b0d8f2e39
No
C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1
Assess if the following substance is a hERG blocker. C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1
fa41bf45-383f-44b2-8533-2a576c4b1162
No
CC(C)Nc1cccnc1N1CCN(C(=O)C2=CC3=C[C@H](NS(C)(=O)=O)C=CC3=N2)CC1
Does the specified drug exhibit hERG blocking activity? CC(C)Nc1cccnc1N1CCN(C(=O)C2=CC3=C[C@H](NS(C)(=O)=O)C=CC3=N2)CC1
570c93a5-510c-460e-a7e3-2c0bc2fc326c
No
Cc1cnc(C(=O)NCCc2ccc(S(=O)([O-])=NC(=O)NC3CCCCC3)cc2)cn1
Determine if the following medication inhibits hERG potassium channels. Cc1cnc(C(=O)NCCc2ccc(S(=O)([O-])=NC(=O)NC3CCCCC3)cc2)cn1
75b836c0-f21b-45b9-b342-749c747496ec
No
CCc1ccc(CCOc2ccc(C[C@H]3SC(=O)NC3=O)cc2)nc1
Is the drug provided capable of blocking hERG channels? CCc1ccc(CCOc2ccc(C[C@H]3SC(=O)NC3=O)cc2)nc1
aaa491a6-489d-4259-a269-bfc4049f5e3f
No
CCc1cc(C(N)=S)ccn1
Does the specified drug exhibit hERG blocking activity? CCc1cc(C(N)=S)ccn1
8f509fe2-f12f-4d73-9e10-10b945788ecb
No
Nc1c2c(nc3ccccc13)CCCC2
Determine if the following medication inhibits hERG potassium channels. Nc1c2c(nc3ccccc13)CCCC2
2db9bb49-8a3c-4bb1-aa65-bf0730d79e83
No
CC(C)(C#N)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1
Is this pharmaceutical compound a blocker of the hERG ion channel? CC(C)(C#N)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1
b0f2fd92-a78d-4b37-b748-897f8c9d8b0b
No
O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N1
Verify if this drug has hERG blocking properties. O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N1
fdb04077-57a6-467a-88b2-83aaada71e96
No
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C
Is the drug provided capable of blocking hERG channels? C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C