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Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.
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These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).
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We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.
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CASE: Because of menorrhagia, the patient had begun an oral contraceptive pill (OCP) 1(1/2) months prior to presentation.
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The toxic effects of imatinib treatment are usually mild, and serious adverse events are rare.
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Both authors discuss a method of creating a postauricular pocket, burying the ear pedicle, and using costal cartilage for an inlay helical graft.
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The histological findings of marked cholestasis without evidence of extrahepatic biliary obstruction or acute hepatitis were compatible with the diagnosis of drug-induced liver disease.
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Spindle coma in benzodiazepine toxicity: case report.
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We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.
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She had been receiving oral colchicine therapy for mixed connective tissue disease.
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A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.
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D-penicillamine was withdrawn and glucocorticoids combined with azathioprine were given with good recovery of renal function.
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After five months of initiation of treatment, while receiving RHE, he developed painful bilateral gynaecomastia.
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We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).
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The present case is a young adult who had severe almost continuous hiccups for 3 years after placement of a feeding gastrostomy and Nissen fundoplication.
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OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.
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This likely explains the noted response to a calcium channel blocker (CCB), namely diltiazem.
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A bone marrow aspiration showed slight hypoplasia with normocellular marrow.
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Tegaserod, a potent partial agonist of the serotonin 5-HT4 receptor, is used to treat women with constipation-predominant irritable bowel syndrome.
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The carers assessed the pre-morbid and present behaviour and personality of the patients using standard questionnaires.
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In addition, cardiac adverse effects usually develop after at least 6 days of therapy.
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As in this case, infection may be systemic and not confined to the intestine.
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This combination was shown to be synergistic.
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Most patients showed some element of dose dependency between antiparkinsonian drugs and the hypersexual behavior.
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Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.
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Biochemical parameters of liver cell damage returned to normal levels 6 months later.
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CONCLUSION: COCs can be used in patients with thrombogenic mutations and anticoagulatory therapy in individual cases.
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Audiograms showed bilateral sensorineural hearing loss with cochlear lesions.
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Acute spontaneous spinal epidural hematoma: an important differential diagnosis in patients under clopidogrel therapy.
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An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.
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The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.
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Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.
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Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease.
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PURPOSE: The purpose of this study was to evaluate the differential diagnosis of pulmonary nodules by conventional radiography and computed tomography (CT) in osteosarcoma patients with central venous catheter.
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We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.
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Three men and 2 women aged 38 to 53 years were treated.
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The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature.
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He was treated with phenytoin from the age of 2 years and 7 months.
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In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.
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Administration of cidofovir was associated with clearance of BK virus DNA from blood and stabilization of renal function in 5 cases.
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Methemoglobinemia associated with dermal application of benzocaine cream in a cat.
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Over several weeks, all neurologic and imaging deficits resolved.
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Continued study of the specific mechanisms leading to ventricular tachycardia and sudden death are needed in order to control this increasingly prevalent clinical problem.
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Most new drug therapies require randomized data to show effects before widespread use and acceptance occur.
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Twenty patients with bladder cancer were treated by semiselective intra-arterial chemotherapy with Adriamycin.
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We report a case of a 26-year-old woman, who presented with an itchy erythematous reaction and strong oedema localized to the face.
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Since continuation/maintenance ECT is not well established, prophylactic therapy in recurrent illnesses is more commonly carried out using antidepressive medication alone or more often in combination with lithium.
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There is almost always a hypopyon present, and the uveitis progresses aggressively.
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The second patient, a 60-year-old woman, was hospitalized because of a corneal ulcer in her left eye.
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Histological examination of a skin biopsy was consistent with leucocytoclastic vasculitis.
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Other pharmacologic interventions, based on the physiology of erections, are presented.
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Initial pulse oximetry on room air was 72% and improved minimally with supplemented oxygen.
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The multidisciplinary team's successful decision to trial SFG in a medically complex patient allowed profound iron deficiency to be treated safely and effectively, which was not possible prior to the availability of an alternate iron preparation.
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CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.
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Specifically, for children with a family history of gallbladder, biliary tract, liver or pancreas dysfunction, ceftriaxone may not be the drug of choice since the likelihood of complications is increased in this population.
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A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.
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A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.
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At autopsy adenovirus was identified in her bladder, kidneys and lungs.
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We report here three patients with hematologic malignancies and one patient with metastatic carcinoma with chemotherapy-induced leukoencephalopathy.
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Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.
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Acute leukemia after cytotoxic treatment for nonmalignant disease in childhood.
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We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.
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We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.
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Until the frequency of this adverse reaction is clearer, it would seem advisable to ensure that plasma HDL cholesterol is documented before and rechecked after commencement of thiazolidinedione therapy.
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Lithium medication during pregnancy is uncommon and the problems of a neonate who has been exposed to lithium represents a rare situation in neonatology.
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Early recognition and treatment of postpartum preeclampsia may decrease patient mortality and morbidity by preventing late postpartum eclampsia.
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A ten year old boy who died of the consequences of an infrequent gastrointestinal complication, whilst on induction chemotherapy for acute lymphatic leukemia, is being reported.
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Despite the large number of cases with mediastinitis described in the literature, the chest closure with only an omental flap without closure of subcutaneous tissue and skin is rare.
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The optic nerve appeared healthy, with no visible swelling in each eye.
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The dental surgeon can play an important role in the diagnosis and treatment of such patients.
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At follow-up 1 week later, the patient denied any episodes of hematochezia.
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Unlike fusarial infection in patients with hematologic malignancies or bone marrow transplants, fusarial infection in SOT recipients tends to be localized, occurs later in the posttransplantation period, and has a better outcome.
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RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.
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A desensitization regimen was administered, and she has tolerated all subsequent courses of carboplatin therapy.
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The patients had a history of several hospitalizations and one or two unnecessary laparotomies.
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The difference in DGTX concentration between the unprocessed and dialysed samples was the amount of DGTX bound to plasma proteins and the small fraction of unbound DGTX being relevant for the therapeutic and toxic effects of the drug.
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No anti-Xa activity was demonstrated in breast milk.
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Here we report two cases with HBV carrier status and with non-Hodgkin's lymphoma who were successfully treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation with the administration of lamivudine to prevent HBV flare-up.
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However, because serious hematologic toxicity has been reported, we recommend caution in administration and careful monitoring of blood levels.
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This case is particularly important as the condition will become more and more prevalent and therefore it is imperative that GDPs in primary care are aware of it.
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The period of recovery was consistent with an acute but brief compressive injury and inconsistent with an anesthetic effect.
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CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.
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The patient did well until developing a rapidly progressive lesion of the left neck.
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Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.
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Prolongation of the prothrombin time after organophosphate poisoning.
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Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazole.
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The infusion was terminated and his symptoms abated.
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A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.
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Reviewing our experience with 19 cases of male breast cancer, we found two patients with a 12-year history of estrogen therapy for prostatic carcinoma.
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We have concluded that opioid drugs cause bile duct obstruction in healthy persons.
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Increased libido in a woman treated with fluvoxamine: a case report.
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A 66-year old woman with acute pancreatitis was admitted to our hospital with the complaint of epigastralgia radiating to both flanks for two months.
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Administration of rituximab during the first trimester of pregnancy without consequences for the newborn.
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Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.
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At the age of 14 months a diagnosis of congenital adrenal hyperplasia was made and treatment with dexamethasone (0.125 to 0.25 mg/day) resulted in a fall-off in growth rate, normal advancement in bone age, decrease in virilization and suppression of 17- ketosteroid excretion which continued until 4 3/12 years of age when virilization increased.
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Her serum transaminase and albumin levels were normal.
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Disopyramide (Norpace)-induced hypoglycemia.
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OBJECTIVE: This case study provides general practitioners with a practical approach to seeing patients with chronic pain whom they suspect of opioid dependence and describes a framework for managing chronic pain and dependence within the general practice setting.
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Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.
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On examination, she was slightly confused, mildly dehydrated, had a grade II systolic ejection murmur along the upper left sternal border, had bilateral and symmetric mild weakness of the upper and lower extremities, and exhibited mild edema of the lower extremities.
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