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RESULTS: Topiramate was discontinued.
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Risk factors for neurotoxicity include renal insufficiency, underlying central nervous system (CNS) disease and increased CNS penetration of drug.
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We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.
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The dog responded well to conservative therapy for immune-mediated hemolytic anemia (IMHA).
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A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.
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The median survival was 17 months in patients who had received no prior treatment, and 5 months in those who had received prior chemotherapy.
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On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.
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A 42-year-old man with ankylosing spondylitis that was refractory to nonsteroidal anti-inflammatory drugs as well as various disease-modifying antirheumatic drugs was subjected to anti-TNF compounds.
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Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease?
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Multiple white dandruff-like flakes were seen on the hair coat, especially over the dorsal spine and neck, and the dog expressed increased pruritus by frequently licking and scratching the affected areas.
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In the first 2 cases, injections were perilesional and in the other 2, intralesional.
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We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.
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INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.
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Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.
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Paraplegia following intrathecal cytosine arabinoside.
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Recurrent agranulocytosis induced by two different antithyroid agents.
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In this report, a case is described of C. indologenes bacteraemia possibly associated with the use of a peripheral venous catheter.
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The fact that oxcarbazepine is a prodrug and that the formation of the active MHD metabolite is a rate-limiting process may contribute to the relative low toxicity of the drug in overdose.
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Drug-drug interactions are an important concern, as they may increase drug toxicity and, in the case of anticoagulant therapies, increase the risk of hemorrhage.
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Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction.
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Jpn J Ophthalmol 2005;49:231-234 (c) Japanese Ophthalmological Society 2005.
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Her urine output improved gradually and the serum creatinine normalized one month after the initial episode.
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Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.
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The case described here suggests an immune-related mechanism for the development of leukopenia.
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Other reports show increases with the atypical antipsychotics, olanzapine and quetiapine.
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A 42-year-old woman had uneventful bilateral laser-assisted subepithelial keratectomy (LASEK) to correct myopia.
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A 69-year-old man presented with a rare case of retinal artery embolization, which occurred as a complication of carotid angioplasty and carotid artery stenting performed for recurrent cerebral infarction.
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DISCUSSION: AIDS and cryptococcal meningitis, both of which the patient had, can potentially cause seizures.
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The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.
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CONCLUSIONS: This treatment modality appears to provide an additional alternative for managing superficial periocular hemangiomas which threaten vision.
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Clinical and pathological responses of tumor and the side-effects were examined in these two groups.
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We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.
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Fertility was preserved because 7 months later the woman became pregnant and had an uncomplicated pregnancy and delivery at term.
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All 3 patients died.
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An 81-year-old female presented to her local emergency department (ED) with symptoms of bronchitis and was treated with nebulized bronchodilators.
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During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.
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Magnetic resonance imaging showed reversible cortical and subcortical changes consisting of high-intensity lesions on T2-weighted and fluid-attenuated inversion recovery sequences with postgadolinium enhancement, low signal intensity on diffusion-weighted imaging and increased apparent diffusion coefficient.
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Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis.
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This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.
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A potentially fatal complication of these anesthetics is methemoglobinemia (Met-Hgb).
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In the first two infants there was a documented deficiency of vitamin D, but in the second two adequate supplementation was achieved.
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Pharmacokinetic interactions between medications can have clinically significant effects.
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CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.
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Further interrogation of the patient revealed a history of chronic senna intake to treat a chronic constipation.
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We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.
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CMV disease involving central nervous system is an unusual presentation in the setting of SCT.
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Morphine sulfate in controlled-release tablet form is a relatively new oral preparation being used for the relief of chronic severe pain, such as that related to cancer.
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Presented here is the successful treatment of adenomyosis in a woman presenting with menorrhagia, dysmenorrhea, and an enlarging uterus, for whom conservative therapy initiated with mefenamic acid was unsatisfactory.
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We believe that the acute renal failure in our patient was associated with anastrozole.
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The rapid onset of osteomyelitis was impressive.
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Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.
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The patient had advanced malignant mesothelioma and all other methods of pain control had been unsuccessful.
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Clinicians need to maintain a high index of suspicion to diagnose and treat this life-threatening adverse event.
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One-half of the women interviewed reported seeing an advertisement for prescription acne treatment before taking Accutane.
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We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).
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Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.
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It follows that in any case of hymenoptera envenomation a standard ECG is advisable even when a clearly defined allergic reaction is not present.
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CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.
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Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.
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We report a case of cytomegalovirus retinitis which occurred 6 months after renal transplantation and was successfully treated with an investigational drug, ganciclovir (DHPG [Dihydroxy propoxymethyl guanine], Cytovene, BW-B759U), via intravenous administration, with resolution of active retinal lesions and the cessation of cytomegalovirus shedding in the urine.
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At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.
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The highest intraoperative oxygen concentration was 33 percent, but 40 percent oxygen was administered for four days postoperatively.
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The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.
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Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.
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It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.
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Digoxin is a cardiac glycoside used to treat cardiac arrhythmias and heart failure.
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METHODS: We reviewed the records of two patients with a clinical diagnosis of Acanthamoeba keratitis, one with culture-proven Acanthamoeba and the other with a suspected Acanthamoeba infection.
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This was associated with opening the mouth and was thought to be caused by a trigeminovagal reflex.
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(It is no longer contained in Correctol.)
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We believe this case represents a rare complication of anticholinergic therapy.
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Mycophenolate mofetil is a novel immunosuppressive drug already established in transplantation medicine.
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Cisplatin and acute tubular necrosis.
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BCG therapy prevents, or at least delays, tumor progression.
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CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy.
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Three patients, 2 with tardive dyskinesia and 1 with senile chorea, were successfully treated with corticosteroids during an observation period of up to 5 months.
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DESIGN: Observational case report.
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The changes were quantitatively and qualitatively similar to those seen in systemic lupud erythematosus induced by these drugs.
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She was successfully carried through pregnancy and delivered a normal child despite combination chemotherapy.
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Our diagnosis was tuberculosis-related visual loss, which could be due to neuroretinitis, intraocular tuberculosis or chiasmal tuberculoma.
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A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.
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Initial laboratory studies showed severe hypophosphatemia and elevated alkaline phosphatase and serum 1,25-dihydroxyvitamin D levels.
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We report a patient who experienced LABD shortly after starting carbamazepine therapy.
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After three days of salicylate therapy her LFT values began to rise.
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Endophthalmitis developed in the eye and was treated by pars plana vitrectomy, IOL extraction, and intravitreal antibiotic injection.
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AIMS: To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer.
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Protease inhibitor-induced carbamazepine toxicity.
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It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.
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The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.
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We observed a case of withdrawal after abrupt discontinuation of mianserin.
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The ocular and myopic changes cleared up completely on discontinuation of the causative agent.
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Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.
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Transrectal ultrasonography of the prostate demonstrated an average decrease in prostatic volume of 58% at 6 months, with the greatest rate of decrease occurring during the 2nd to 5th months of treatment.
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We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.
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Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare.
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The post-therapy biopsies also showed progestin-related alterations but no evidence of active hyperplasia.
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Proposed mechanisms for leukemogenesis are presented.
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Acanthamoeba keratitis after LASIK.
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Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough.
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We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.
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The patient was brought back to a normal sinus rhythm after a single 300-J counter-shock.
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