PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
1htf
2.2
1,994
G26
B
100
ic50
=
148
nM
-6.829738
MOAD
ic50=148.0nM
P03366,P03366
HIV-1 PROTEASE,HIV-1 PROTEASE
CC1(C)S[C@H]([C@H](NC(=O)Cc2ccccc2)C(=O)NCc2ccccc2)[NH2+][C@H]1C(=O)N[C@@H](CO)Cc1ccccc1
575.755
1.5336
124.14
12
41
5
5
0.224208
1hv5
2.6
2,001
RXP
A
6001
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853,Q02853
STROMELYSIN 3,STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hv5
2.6
2,001
RXP
B
6002
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853
STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hv5
2.6
2,001
RXP
C
6003
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853
STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hv5
2.6
2,001
RXP
D
6004
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853,Q02853
STROMELYSIN 3,STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hv5
2.6
2,001
RXP
E
6005
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853
STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hv5
2.6
2,001
RXP
F
6006
ki
=
5
nM
-8.30103
BindingDB
Ki=5nM
Q02853,Q02853
STROMELYSIN 3,STROMELYSIN 3
NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCc1ccccc1)C[P@](=O)([O-])[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1
693.761
5.4532
166.44
17
50
4
6
0.094544
1hvh
1.8
1,998
Q82
B
265
ki
=
11
nM
-7.958607
MOAD
Ki=11.0nM
P04585,P04585
HIV-1 PROTEASE,HIV-1 PROTEASE
N#C[NH+]=C1N(Cc2ccc(CO)cc2)[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc2ccccc2)N1Cc1ccc(CO)cc1
591.732
1.85108
125.16
10
44
5
5
0.140873
1hvi
1.8
1,994
A77
A
800
ki
=
84
pM
-10.075721
MOAD
Ki=84.0pM
O92139,O92139
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)[C@H](NC(=O)N(C)Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C
794.998
3.6856
189.12
19
58
6
8
0.082942
1hvj
2.0
1,994
A78
A
800
ki
=
4
pM
-11.39794
MOAD
Ki=4.0pM
P04587,P04587
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)[C@H](NC(=O)N(C)Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C
778.999
4.7148
168.89
19
57
5
7
0.091878
1hvk
1.8
1,994
A79
A
800
ki
=
77
pM
-10.113509
MOAD
Ki=77.0pM
P03366,P03366
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)[C@H](NC(=O)N(C)Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C
794.998
3.6856
189.12
19
58
6
8
0.082942
1hvl
1.8
1,994
A76
B
800
ki
=
1,000
pM
-9
MOAD
Ki=1000.0pM
P03367,P03367
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)[C@H](NC(=O)N(C)Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C
794.998
3.6856
189.12
19
58
6
8
0.082942
1hvr
1.8
1,995
XK2
A
263
ki
=
0.31
nM
-9.508638
MOAD
Ki=0.31nM
P04585,P04585
HIV-1 PROTEASE,HIV-1 PROTEASE
O=C1N(Cc2ccc3ccccc3c2)[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc2ccccc2)N1Cc1ccc2ccccc2c1
606.766
7.3752
64.01
8
46
2
3
0.190155
1hvs
2.25
1,995
A77
A
800
ki
=
50
pM
-10.30103
MOAD
Ki=50.0pM
P04587,P04587
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)[C@H](NC(=O)N(C)Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C
794.998
3.6856
189.12
19
58
6
8
0.082942
1hvy
1.9
2,001
D16
C
416
ic50
=
29,000
nM
-4.537602
BindingDB
IC50=29000nM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1hvy
1.9
2,001
D16
D
417
ic50
=
29,000
nM
-4.537602
BindingDB
IC50=29000nM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1hvy
1.9
2,001
D16
A
414
ic50
=
29,000
nM
-4.537602
BindingDB
IC50=29000nM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1hvy
1.9
2,001
D16
B
415
ic50
=
29,000
nM
-4.537602
BindingDB
IC50=29000nM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1hw5
1.82
2,001
CMP
A
211
kd
=
0.5
M
-0.30103
BioLiP
Kb=2.0+-0.3M^-1 (11124966)
P0ACJ8,P0ACJ8
CATABOLITE GENE ACTIVATOR,CATABOLITE GENE ACTIVATOR
Nc1ncnc2c1ncn2[C@H]1O[C@@H]2CO[P@@](=O)([O-])O[C@H]2[C@H]1O
328.201
-1.4494
157.67
1
22
2
11
0.593077
1hw5
1.82
2,001
CMP
A
210
kd
=
0.5
M
-0.30103
BioLiP
Kb=2.0+-0.3M^-1 (11124966)
P0ACJ8,P0ACJ8
CATABOLITE GENE ACTIVATOR,CATABOLITE GENE ACTIVATOR
Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2CO[P@@](=O)([O-])O[C@H]2[C@H]1O
328.201
-1.4494
157.67
1
22
2
11
0.593077
1hw5
1.82
2,001
CMP
B
210
kd
=
0.5
M
-0.30103
BioLiP
Kb=2.0+-0.3M^-1 (11124966)
P0ACJ8,P0ACJ8
CATABOLITE GENE ACTIVATOR,CATABOLITE GENE ACTIVATOR
Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2CO[P@@](=O)([O-])O[C@H]2[C@H]1O
328.201
-1.4494
157.67
1
22
2
11
0.593077
1hw8
2.1
2,001
114
D
3
ic50
=
23
nM
-7.638272
MOAD
ic50=23.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
407.527
2.1349
106.89
10
29
2
6
0.537438
1hw8
2.1
2,001
114
A
2
ic50
=
23
nM
-7.638272
MOAD
ic50=23.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC[C@@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
407.527
2.1349
106.89
10
29
2
6
0.537438
1hw8
2.1
2,001
114
B
1
ic50
=
23
nM
-7.638272
MOAD
ic50=23.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
407.527
2.1349
106.89
10
29
2
6
0.537438
1hw8
2.1
2,001
114
C
4
ic50
=
23
nM
-7.638272
MOAD
ic50=23.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
407.527
2.1349
106.89
10
29
2
6
0.537438
1hw9
2.33
2,001
SIM
C
1
ic50
=
11
nM
-7.958607
MOAD
ic50=11.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
435.581
2.771
106.89
10
31
2
6
0.511142
1hw9
2.33
2,001
SIM
C
2
ic50
=
11
nM
-7.958607
MOAD
ic50=11.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
435.581
2.771
106.89
10
31
2
6
0.511142
1hw9
2.33
2,001
SIM
A
4
ic50
=
11
nM
-7.958607
MOAD
ic50=11.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
435.581
2.771
106.89
10
31
2
6
0.511142
1hw9
2.33
2,001
SIM
B
3
ic50
=
11
nM
-7.958607
MOAD
ic50=11.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21
435.581
2.771
106.89
10
31
2
6
0.511142
1hwi
2.3
2,001
115
A
2
ic50
=
28
nM
-7.552842
MOAD
ic50=28.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21
410.465
3.2934
85.52
8
30
2
5
0.596758
1hwi
2.3
2,001
115
B
1
ic50
=
28
nM
-7.552842
MOAD
ic50=28.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21
410.465
3.2934
85.52
8
30
2
5
0.596758
1hwi
2.3
2,001
115
C
4
ic50
=
28
nM
-7.552842
MOAD
ic50=28.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21
410.465
3.2934
85.52
8
30
2
5
0.596758
1hwi
2.3
2,001
115
D
3
ic50
=
28
nM
-7.552842
MOAD
ic50=28.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21
410.465
3.2934
85.52
8
30
2
5
0.596758
1hwj
2.26
2,001
116
D
3
ic50
=
10
nM
-8
MOAD
ic50=10.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
COCc1c(C(C)C)nc(C(C)C)c(CC[C@@H](O)C[C@@H](O)CC(=O)[O-])c1-c1ccc(F)cc1
460.566
3.4654
102.71
12
33
2
6
0.502861
1hwj
2.26
2,001
116
C
4
ic50
=
10
nM
-8
MOAD
ic50=10.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
COCc1c(C(C)C)nc(C(C)C)c(CC[C@@H](O)C[C@@H](O)CC(=O)[O-])c1-c1ccc(F)cc1
460.566
3.4654
102.71
12
33
2
6
0.502861
1hwj
2.26
2,001
116
A
2
ic50
=
10
nM
-8
MOAD
ic50=10.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
COCc1c(C(C)C)nc(C(C)C)c(CC[C@@H](O)C[C@@H](O)CC(=O)[O-])c1-c1ccc(F)cc1
460.566
3.4654
102.71
12
33
2
6
0.502861
1hwj
2.26
2,001
116
B
1
ic50
=
10
nM
-8
MOAD
ic50=10.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
COCc1c(C(C)C)nc(C(C)C)c(CC[C@@H](O)C[C@@H](O)CC(=O)[O-])c1-c1ccc(F)cc1
460.566
3.4654
102.71
12
33
2
6
0.502861
1hwk
2.22
2,001
117
A
2
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
557.642
4.9789
114.62
12
41
3
6
0.227385
1hwk
2.22
2,001
117
B
1
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
557.642
4.9789
114.62
12
41
3
6
0.227385
1hwk
2.22
2,001
117
C
4
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
557.642
4.9789
114.62
12
41
3
6
0.227385
1hwk
2.22
2,001
117
D
3
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
557.642
4.9789
114.62
12
41
3
6
0.227385
1hwl
2.1
2,001
FBI
C
4
ic50
=
5
nM
-8.30103
MOAD
ic50=5.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
482.554
0.9864
143.75
11
33
2
8
0.482466
1hwl
2.1
2,001
FBI
A
2
ic50
=
5
nM
-8.30103
MOAD
ic50=5.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
482.554
0.9864
143.75
11
33
2
8
0.482466
1hwl
2.1
2,001
FBI
B
1
ic50
=
5
nM
-8.30103
MOAD
ic50=5.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
482.554
0.9864
143.75
11
33
2
8
0.482466
1hwl
2.1
2,001
FBI
D
3
ic50
=
5
nM
-8.30103
MOAD
ic50=5.0nM
P04035,P04035
HMG-COA REDUCTASE,HMG-COA REDUCTASE
CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CC[C@@H](O)C[C@@H](O)CC(=O)[O-]
482.554
0.9864
143.75
11
33
2
8
0.482466
1hwr
1.8
1,999
216
B
216
ki
=
4.7
nM
-8.327902
MOAD
Ki=4.7nM
P04585,P04585
HIV-1 PROTEASE,HIV-1 PROTEASE
C=CCN1C(=O)N(CC=C)[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@H]1Cc1ccccc1
406.526
3.0404
64.01
8
30
2
3
0.662602
1hww
1.87
2,002
SWA
A
1103
ic50
=
20
nM
-7.69897
MOAD
ic50=20.0nM
Q24451
ALPHA-MANNOSIDASE II
O[C@H]1[C@H]2[C@H](O)CCC[N@@H+]2C[C@H]1O
174.22
-2.87
65.13
0
12
4
3
0.319084
1hxb
2.3
1,997
ROC
A
100
ki
=
0.12
nM
-9.920819
MOAD
Ki=0.12nM
P04585,P04585
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2C[N@H+]1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1
671.863
1.6753
167.95
12
49
6
6
0.171369
1hxk
1.5
2,002
DMJ
A
1103
ic50
=
400
uM
-3.39794
MOAD
ic50=400.0uM
Q24451
ALPHA-MANNOSIDASE II
OC[C@H]1[NH2+]C[C@@H](O)[C@@H](O)[C@@H]1O
164.181
-3.993
97.53
1
11
5
4
0.272743
1hxw
1.8
1,998
RIT
B
301
ki
=
15
pM
-10.823909
MOAD
Ki=15.0pM
P12499,P12499
HIV-1 PROTEASE,HIV-1 PROTEASE
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1
720.962
5.9052
145.78
17
50
4
9
0.10624
1hy7
1.5
2,002
MBS
B
901
ic50
=
4,090
nM
-5.388277
MOAD
ic50=4090.0nM
P08254
STROMELYSIN-1
COCC#CC[C@@H](NS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1)C(=O)[O-]
402.448
0.7989
104.76
8
28
1
6
0.655128
1hyo
1.3
2,001
HBU
A
1012
ki
=
84.8
uM
-4.071604
MOAD
Ki=84.8uM
P35505,P35505
FUMARYLACETOACETATE HYDROLASE,FUMARYLACETOACETATE HYDROLASE
C[P@@](=O)([O-])CC(=O)CC(=O)[O-]
178.08
-2.0363
97.33
4
11
0
5
0.36468
1hyo
1.3
2,001
HBU
B
1011
ki
=
84.8
uM
-4.071604
MOAD
Ki=84.8uM
P35505,P35505
FUMARYLACETOACETATE HYDROLASE,FUMARYLACETOACETATE HYDROLASE
C[P@@](=O)([O-])CC(=O)CC(=O)[O-]
178.08
-2.0363
97.33
4
11
0
5
0.36468
1hzz
2.5
2,001
NAD
A
400
kd
=
30
uM
-4.522879
MOAD
Kd=30.0uM
Q2RSB2,Q2RSB2
PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA,PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
1i00
2.5
2,001
D16
B
409
ki
=
0.46
uM
-6.337242
MOAD
Ki=0.46uM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1i00
2.5
2,001
D16
A
315
ki
=
0.46
uM
-6.337242
MOAD
Ki=0.46uM
P04818,P04818
THYMIDYLATE SYNTHASE,THYMIDYLATE SYNTHASE
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])s3)ccc2[nH]1
456.48
-0.69218
158.35
9
32
2
9
0.427987
1i1e
2.5
2,001
DM2
A
3001
kd
=
9.4
uM
-5.026872
MOAD
Kd=9.4uM
P10844
BOTULINUM NEUROTOXIN TYPE B
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H]([NH3+])[C@H](O)[C@H](C)O1
544.533
-0.7155
207.69
5
39
6
11
0.221002
1i2z
2.8
2,002
654
B
1502
ic50
=
13,700
nM
-4.863279
BindingDB
IC50=13700nM
P0AEK4,P0AEK4
ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH],ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]
Cc1ccc(Cn2cnc(-c3cccs3)c2)cc1
254.358
3.96832
17.82
3
18
0
3
0.691267
1i2z
2.8
2,002
654
A
502
ic50
=
13,700
nM
-4.863279
BindingDB
IC50=13700nM
P0AEK4,P0AEK4
ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH],ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]
Cc1ccc(Cn2cnc(-c3cccs3)c2)cc1
254.358
3.96832
17.82
3
18
0
3
0.691267
1i37
2.0
2,001
DHT
A
201
ki
=
0.43
nM
-9.366532
BindingDB
IC50=3.1nM,EC50=0.97nM,Ki=0.43nM
P15207
ANDROGEN RECEPTOR
C[C@]12CCC(=O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12
290.447
3.9591
37.3
0
21
1
2
0.732973
1i38
2.0
2,001
DHT
A
201
ki
=
0.43
nM
-9.366532
BindingDB
IC50=3.1nM,EC50=0.97nM,Ki=0.43nM
P15207
ANDROGEN RECEPTOR
C[C@]12CCC(=O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12
290.447
3.9591
37.3
0
21
1
2
0.732973
1i4d
2.5
2,001
GDP
D
200
kd
=
3
uM
-5.522879
MOAD
Kd=3.0uM
P63000
RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
440.178
-4.3487
261.06
6
28
4
15
0.309446
1i5r
1.6
2,003
HYC
A
328
ki
=
3
nM
-8.522879
MOAD
Ki=3.0nM
P14061
TYPE 1 17 BETA-HYDROXYSTEROID DEHYDROGENASE
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1C[C@H](CCCCCCCCC(=O)OC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)[C@@H]2O
677.843
4.5406
186.07
12
49
5
12
0.133862
1i7g
2.2
2,002
AZ2
A
469
ic50
=
1
uM
-6
MOAD
ic50=1.0uM
Q07869
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA
CCO[C@@H](Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)[O-]
407.464
1.344
101.96
11
28
0
7
0.518119
1i7i
2.35
2,002
AZ2
A
101
ki
=
18
nM
-7.744727
BindingDB
EC50=704nM,Ki=18nM
P37231
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
CCO[C@@H](Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)[O-]
407.464
1.344
101.96
11
28
0
7
0.518119
1i7i
2.35
2,002
AZ2
B
478
ki
=
18
nM
-7.744727
BindingDB
EC50=704nM,Ki=18nM
P37231
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
CCO[C@@H](Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)[O-]
407.464
1.344
101.96
11
28
0
7
0.518119
1i7z
2.3
2,001
COC
A
301
kd
=
0.4
uM
-6.39794
MOAD
Kd=0.4uM
P01834,P01857,P01857
CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION,CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION,CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION
COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1[N@H+]2C
304.366
0.4506
57.04
3
22
1
4
0.823989
1i7z
2.3
2,001
COC
C
302
kd
=
0.4
uM
-6.39794
MOAD
Kd=0.4uM
P01834,P01834,P01857,P01857
CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION,CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION,CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION,CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION
COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1[N@H+]2C
304.366
0.4506
57.04
3
22
1
4
0.823989
1i80
2.0
2,001
9HX
B
302
kd
=
0.39
uM
-6.408935
MOAD
Kd=0.39uM
P9WP01,P9WP01
PURINE NUCLEOSIDE PHOSPHORYLASE,PURINE NUCLEOSIDE PHOSPHORYLASE
O=c1[nH]cnc2cc[nH]c12
135.126
0.2512
61.54
0
10
2
2
0.543565
1i80
2.0
2,001
9HX
C
303
kd
=
0.39
uM
-6.408935
MOAD
Kd=0.39uM
P9WP01,P9WP01
PURINE NUCLEOSIDE PHOSPHORYLASE,PURINE NUCLEOSIDE PHOSPHORYLASE
O=c1[nH]cnc2cc[nH]c12
135.126
0.2512
61.54
0
10
2
2
0.543565
1i80
2.0
2,001
9HX
A
301
kd
=
0.39
uM
-6.408935
MOAD
Kd=0.39uM
P9WP01,P9WP01
PURINE NUCLEOSIDE PHOSPHORYLASE,PURINE NUCLEOSIDE PHOSPHORYLASE
O=c1[nH]cnc2cc[nH]c12
135.126
0.2512
61.54
0
10
2
2
0.543565
1i8z
1.93
2,001
INL
A
555
ic50
=
1.27
nM
-8.896196
MOAD
ic50=1.27nM
P00918
CARBONIC ANHYDRASE II
COc1cccc(N2C(C[NH+]3CCOCC3)=Cc3cc(S(N)(=O)=O)sc3S2(=O)=O)c1
472.59
-0.131
120.44
5
30
2
7
0.625518
1i90
2.0
2,001
INM
A
555
ic50
=
1.28
nM
-8.89279
MOAD
ic50=1.28nM
P00918
CARBONIC ANHYDRASE II
COCCCN1C=C(N)c2cc(S(N)(=O)=O)sc2S1(=O)=O
353.447
-0.3066
132.79
5
21
2
7
0.697925
1i91
2.0
2,001
INQ
A
555
ic50
=
1.15
nM
-8.939302
MOAD
ic50=1.15nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1cc2c(s1)S(=O)(=O)N(c1cccc(O)c1)C(C[NH+]1CCOCC1)=C2
458.563
-0.434
131.44
4
29
3
7
0.569614
1i9l
1.93
2,001
INV
A
666
kd
=
3.3
nM
-8.481486
MOAD
Kd=3.3nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)cc2)cc1
308.334
1.4031
89.26
4
21
2
3
0.894477
1i9l
1.93
2,001
INV
A
555
kd
=
3.3
nM
-8.481486
MOAD
Kd=3.3nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)cc2)cc1
308.334
1.4031
89.26
4
21
2
3
0.894477
1i9m
1.84
2,001
INW
A
555
kd
=
3.3
nM
-8.481486
MOAD
Kd=3.3nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)cc2F)cc1
326.324
1.5422
89.26
4
22
2
3
0.892985
1i9m
1.84
2,001
INW
A
666
kd
=
3.3
nM
-8.481486
MOAD
Kd=3.3nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)cc2F)cc1
326.324
1.5422
89.26
4
22
2
3
0.892985
1i9n
1.86
2,001
IOA
A
555
kd
=
2.2
nM
-8.657577
MOAD
Kd=2.2nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2cc(F)ccc2F)cc1
326.324
1.5422
89.26
4
22
2
3
0.892985
1i9o
1.86
2,001
IOC
A
666
kd
=
3.8
nM
-8.420216
MOAD
Kd=3.8nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)c(F)c2F)cc1
344.314
1.6813
89.26
4
23
2
3
0.827225
1i9o
1.86
2,001
IOC
A
555
kd
=
3.8
nM
-8.420216
MOAD
Kd=3.8nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2ccc(F)c(F)c2F)cc1
344.314
1.6813
89.26
4
23
2
3
0.827225
1i9p
1.92
2,001
IOE
A
555
kd
=
3.9
nM
-8.408935
MOAD
Kd=3.9nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2c(F)cc(F)cc2F)cc1
344.314
1.6813
89.26
4
23
2
3
0.884297
1i9q
1.8
2,001
IOF
A
666
kd
=
3.9
nM
-8.408935
MOAD
Kd=3.9nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2cc(F)c(F)c(F)c2)cc1
344.314
1.6813
89.26
4
23
2
3
0.827225
1i9q
1.8
2,001
IOF
A
555
kd
=
3.9
nM
-8.408935
MOAD
Kd=3.9nM
P00918
CARBONIC ANHYDRASE II
NS(=O)(=O)c1ccc(C(=O)NCc2cc(F)c(F)c(F)c2)cc1
344.314
1.6813
89.26
4
23
2
3
0.827225
1ia1
1.7
2,001
TQ3
B
196
ic50
=
0.034
uM
-7.468521
MOAD
ic50=0.034uM
P22906
DIHYDROFOLATE REDUCTASE
Nc1nc(N)c2c(Sc3ccccc3)cccc2n1
268.345
2.9454
77.82
2
19
2
5
0.746799
1ia1
1.7
2,001
TQ3
A
194
ic50
=
0.034
uM
-7.468521
MOAD
ic50=0.034uM
P22906
DIHYDROFOLATE REDUCTASE
Nc1nc(N)c2c(Sc3ccccc3)cccc2n1
268.345
2.9454
77.82
2
19
2
5
0.746799
1ia2
1.82
2,001
TQ4
A
194
ic50
=
0.023
uM
-7.638272
MOAD
ic50=0.023uM
P22906
DIHYDROFOLATE REDUCTASE
Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1
282.372
3.25382
77.82
2
20
2
5
0.754037
1ia2
1.82
2,001
TQ4
B
196
ic50
=
0.023
uM
-7.638272
MOAD
ic50=0.023uM
P22906
DIHYDROFOLATE REDUCTASE
Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1
282.372
3.25382
77.82
2
20
2
5
0.754037
1ia3
1.78
2,001
TQ5
A
194
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P22906
DIHYDROFOLATE REDUCTASE
CC(C)(C)c1ccc(Sc2cccc3nc(N)nc(N)c23)cc1
324.453
4.2429
77.82
2
23
2
5
0.736828
1ia3
1.78
2,001
TQ5
B
196
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P22906
DIHYDROFOLATE REDUCTASE
CC(C)(C)c1ccc(Sc2cccc3nc(N)nc(N)c23)cc1
324.453
4.2429
77.82
2
23
2
5
0.736828
1ia4
1.85
2,001
TQ6
B
196
ic50
=
0.13
uM
-6.886057
MOAD
ic50=0.13uM
P22906
DIHYDROFOLATE REDUCTASE
Nc1nc(N)c2c(Sc3ccc(N4CCOCC4)cc3)cccc2n1
353.451
2.782
90.29
3
25
2
7
0.748007
1ia4
1.85
2,001
TQ6
A
194
ic50
=
0.13
uM
-6.886057
MOAD
ic50=0.13uM
P22906
DIHYDROFOLATE REDUCTASE
Nc1nc(N)c2c(Sc3ccc(N4CCOCC4)cc3)cccc2n1
353.451
2.782
90.29
3
25
2
7
0.748007
1ict
3.0
2,002
T44
D
129
ic50
=
10,500
nM
-4.978811
BindingDB
IC50=10500nM
P02766,P02766,P02766,P02766
TRANSTHYRETIN,TRANSTHYRETIN,TRANSTHYRETIN,TRANSTHYRETIN
[NH3+][C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-]
776.872
2.5058
97.23
5
24
2
4
0.457094
1ict
3.0
2,002
T44
C
128
ic50
=
10,500
nM
-4.978811
BindingDB
IC50=10500nM
P02766,P02766,P02766,P02766
TRANSTHYRETIN,TRANSTHYRETIN,TRANSTHYRETIN,TRANSTHYRETIN
[NH3+][C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-]
776.872
2.5058
97.23
5
24
2
4
0.457094
1ida
1.7
1,995
0PO
B
100
ic50
<
2
nM
-8.69897
MOAD
ic50<2.0nM
P04584,P04584
Protease,Protease
CC(C)[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C[N@@H+]1CC[C@@H](SCc2cccnc2)C[C@H]1C(=O)NC(C)(C)C
725.98
3.7366
137.75
14
52
5
7
0.133701
1idb
2.2
1,995
0DO
B
100
ic50
=
11
nM
-7.958607
MOAD
ic50=11.0nM
P04584,P04584
Protease,Protease
Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)C[N@@H+]1CC[C@@H](S(=O)(=O)c2ccncc2)C[C@H]1C(=O)NC(C)(C)C
651.85
1.97014
139.13
12
46
4
7
0.235002
1ie3
2.5
2,001
PYR
C
317
ki
=
56
mM
-1.251812
MOAD
Ki=56.0mM
P61889,P61889
MALATE DEHYDROGENASE,MALATE DEHYDROGENASE
CC(=O)C(=O)[O-]
87.054
-1.6747
57.2
1
6
0
3
0.358965
1ie9
1.4
2,001
VDX
A
500
kd
=
0.065
nM
-10.187087
BindingDB
EC50=10nM,IC50=1.1nM,Kd=0.065nM
P11473
VITAMIN D3 RECEPTOR
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
1iei
2.5
2,002
ZES
A
351
ic50
=
44
nM
-7.356547
MOAD
ic50=44.0nM
P15121
ALDOSE REDUCTASE
O=C([O-])Cn1c(=O)n(Cc2ccc(Br)cc2F)c(=O)c2ccc(Cl)cc21
440.632
1.5164
84.13
4
26
0
6
0.615679
1iep
2.1
2,001
STI
A
201
ic50
=
100
nM
-7
MOAD
ic50=100.0nM
P00520
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL
Cc1ccc(NC(=O)c2ccc(C[NH+]3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
494.623
3.17322
87.48
7
37
3
6
0.365917