PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6kbf
1.92
2,020
D4X
B
602
ic50
=
308
nM
-6.511449
MOAD
ic50=308.0nM
W7JP72,W7JP72
Lysine--tRNA ligase,Lysine--tRNA ligase
C[C@H]1CCC[C@H](C[C@H]2Cc3cc(O)cc(O)c3C(=O)N2)C1
289.375
2.9687
69.56
2
21
3
3
0.783666
6kcn
2.2
2,020
D5F
A
601
ic50
=
276
nM
-6.559091
MOAD
ic50=276.0nM
W7JP72,W7JP72
Lysine--tRNA ligase,Lysine--tRNA ligase
C[C@H]1CCC[C@H](Cc2cc3cc(O)cc(O)c3c(=O)o2)C1
288.343
3.573
70.67
2
21
2
4
0.885838
6kcn
2.2
2,020
D5F
B
601
ic50
=
276
nM
-6.559091
MOAD
ic50=276.0nM
W7JP72,W7JP72
Lysine--tRNA ligase,Lysine--tRNA ligase
C[C@H]1CCC[C@H](Cc2cc3cc(O)cc(O)c3c(=O)o2)C1
288.343
3.573
70.67
2
21
2
4
0.885838
6kcn
2.2
2,020
D5F
C
601
ic50
=
276
nM
-6.559091
MOAD
ic50=276.0nM
W7JP72,W7JP72
Lysine--tRNA ligase,Lysine--tRNA ligase
C[C@H]1CCC[C@H](Cc2cc3cc(O)cc(O)c3c(=O)o2)C1
288.343
3.573
70.67
2
21
2
4
0.885838
6kcn
2.2
2,020
D5F
D
601
ic50
=
276
nM
-6.559091
MOAD
ic50=276.0nM
W7JP72,W7JP72
Lysine--tRNA ligase,Lysine--tRNA ligase
C[C@H]1CCC[C@H](Cc2cc3cc(O)cc(O)c3c(=O)o2)C1
288.343
3.573
70.67
2
21
2
4
0.885838
6kcx
1.933
2,020
CIT
A
505
ic50
=
6
mM
-2.221849
MOAD
ic50=6.0mM
Q9WZL1
Alpha-glucosidase, putative
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
189.099
-5.2526
140.62
5
13
1
7
0.454904
6kcx
1.933
2,020
CIT
A
504
ic50
=
6
mM
-2.221849
MOAD
ic50=6.0mM
Q9WZL1
Alpha-glucosidase, putative
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
189.099
-5.2526
140.62
5
13
1
7
0.454904
6kda
2.909
2,020
SAH
A
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UBC3,Q9UJW3
DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3-like
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kda
2.909
2,020
SAH
D
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UJW3,Q9UBC3
DNA (cytosine-5)-methyltransferase 3-like,DNA (cytosine-5)-methyltransferase 3B
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdb
2.862
2,020
SAH
A
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UBC3,Q9UJW3
DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3-like
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdb
2.862
2,020
SAH
D
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UJW3,Q9UBC3
DNA (cytosine-5)-methyltransferase 3-like,DNA (cytosine-5)-methyltransferase 3B
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdl
3.274
2,020
SAH
A
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UBC3,Q9UJW3
DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3-like
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdl
3.274
2,020
SAH
D
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UJW3,Q9UBC3
DNA (cytosine-5)-methyltransferase 3-like,DNA (cytosine-5)-methyltransferase 3B
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdt
2.87
2,020
SAH
A
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UBC3,Q9UJW3
DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3-like
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdt
2.87
2,020
SAH
D
901
ic50
=
300
nM
-6.522879
BindingDB
IC50=300nM
Q9UJW3,Q9UBC3
DNA (cytosine-5)-methyltransferase 3-like,DNA (cytosine-5)-methyltransferase 3B
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6kdx
2.44
2,019
D6X
A
803
ic50
=
294
nM
-6.531653
MOAD
ic50=294.0nM
Q9Y233,Q9Y233
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Cc1cc(C)n2nc(CCNc3ccc4ccccc4n3)nc2n1
318.384
2.94394
68
4
24
1
6
0.626395
6kdz
3.1
2,019
D79
A
803
ic50
=
2.9
nM
-8.537602
BindingDB
IC50=2.9nM
Q9Y233,Q9Y233
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Cc1cc(C)n2nc(CCc3cc(O)n4nc5ncccc5c4n3)nc2n1
360.381
1.82284
106.39
3
27
1
9
0.522882
6ke0
2.95
2,019
D7C
A
803
ic50
=
69
nM
-7.161151
BindingDB
IC50=69nM
Q9Y233,Q9Y233
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Cc1cc(C)n2nc(CC(=O)N3c4nc5ccccc5n4C[C@@H]3C)nc2n1
361.409
2.06864
81.21
2
27
0
7
0.545893
6kee
2.12154661767
2,020
D7U
A
201
ic50
=
7.4
nM
-8.130768
BindingDB
IC50=7.4nM
O60885
Bromodomain-containing protein 4
Cc1cc(-c2cc(CS(C)(=O)=O)cnc2Oc2ccc(F)cc2F)n2cc[nH]c(=O)c12
445.447
3.61312
93.53
5
31
1
6
0.506581
6kef
2.44467544859
2,020
D7X
A
201
ic50
=
15
nM
-7.823909
BindingDB
IC50=15nM
O60885
Bromodomain-containing protein 4
Cc1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)n2cc[nH]c(=O)c12
409.467
3.76682
92.67
5
29
2
5
0.52481
6kg2
2.25
2,019
D8C
A
500
ic50
=
0.048
uM
-7.318759
MOAD
ic50=0.048uM
P13995
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Cc1c(N2CC[NH+](C)CC2)ccc2c3c(c(=O)oc12)CN(C(=O)c1ccc(NS(C)(=O)=O)c(Cl)c1)CC3
546.069
1.65952
104.37
4
37
2
6
0.483285
6kg2
2.25
2,019
D8C
B
500
ic50
=
0.048
uM
-7.318759
MOAD
ic50=0.048uM
P13995
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Cc1c(N2CC[NH+](C)CC2)ccc2c3c(c(=O)oc12)CN(C(=O)c1ccc(NS(C)(=O)=O)c(Cl)c1)CC3
546.069
1.65952
104.37
4
37
2
6
0.483285
6khe
2.8
2,019
3NG
A
1000
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
P49760
Dual specificity protein kinase CLK2
O=C([O-])c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
348.769
3.5435
77.94
3
25
1
5
0.572803
6khf
2.598
2,019
3NG
A
1000
ic50
=
41
nM
-7.387216
BindingDB
IC50=41nM
P49761
Dual specificity protein kinase CLK3
O=C([O-])c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
348.769
3.5435
77.94
3
25
1
5
0.572803
6kjz
2.20000094865
2,020
MKU
A
503
ic50
=
420
nM
-6.376751
MOAD
ic50=420.0nM
Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)CCC(C)(C)O4
410.466
4.9783
89.13
3
30
2
6
0.467663
6kjz
2.20000094865
2,020
MKU
B
503
ic50
=
420
nM
-6.376751
MOAD
ic50=420.0nM
Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)CCC(C)(C)O4
410.466
4.9783
89.13
3
30
2
6
0.467663
6kk0
2.20008760676
2,020
M36
A
501
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
COc1c(OCCCCCCC(=O)[O-])cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4
535.613
5.4325
118.26
11
39
1
8
0.196102
6kk0
2.20008760676
2,020
M36
B
501
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
COc1c(OCCCCCCC(=O)[O-])cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4
535.613
5.4325
118.26
11
39
1
8
0.196102
6klk
1.759
2,019
URF
A
501
kd
=
133.2
uM
-3.875496
MOAD
Kd=133.2uM
Q9I676
D-hydantoinase/dihydropyrimidinase
O=c1[nH]cc(F)c(=O)[nH]1
130.078
-0.7977
65.72
0
9
2
2
0.482565
6klz
0.9
2,020
BCT
A
303
ki
=
85,000,000
nM
-1.070581
BindingDB
Ki=85000000nM
P00918
Carbonic anhydrase 2
O=C([O-])[O-]
60.008
-2.447
63.19
0
4
0
3
0.311555
6km0
0.93
2,020
BCT
A
303
ki
=
85,000,000
nM
-1.070581
BindingDB
Ki=85000000nM
P00918
Carbonic anhydrase 2
O=C([O-])[O-]
60.008
-2.447
63.19
0
4
0
3
0.311555
6km1
1.05
2,020
BCT
A
304
ki
=
85,000,000
nM
-1.070581
BindingDB
Ki=85000000nM
P00918
Carbonic anhydrase 2
O=C([O-])[O-]
60.008
-2.447
63.19
0
4
0
3
0.311555
6km2
0.9
2,020
BCT
A
304
ki
=
85,000,000
nM
-1.070581
BindingDB
Ki=85000000nM
P00918
Carbonic anhydrase 2
O=C([O-])[O-]
60.008
-2.447
63.19
0
4
0
3
0.311555
6knh
1.76
2,019
CIT
A
501
ic50
=
280
uM
-3.552842
MOAD
ic50=280.0uM
A0A0H3JPF2,A0A0H3JPF2
Probable diaminopimelate decarboxylase protein,Probable diaminopimelate decarboxylase protein
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
189.099
-5.2526
140.62
5
13
1
7
0.454904
6knh
1.76
2,019
CIT
B
501
ic50
=
280
uM
-3.552842
MOAD
ic50=280.0uM
A0A0H3JPF2,A0A0H3JPF2
Probable diaminopimelate decarboxylase protein,Probable diaminopimelate decarboxylase protein
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
189.099
-5.2526
140.62
5
13
1
7
0.454904
6knh
1.76
2,019
CIT
C
501
ic50
=
280
uM
-3.552842
MOAD
ic50=280.0uM
A0A0H3JPF2
Probable diaminopimelate decarboxylase protein
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
189.099
-5.2526
140.62
5
13
1
7
0.454904
6knr
2.804
2,020
DL9
A
501
ic50
=
56
nM
-7.251812
BindingDB
IC50=56.0nM
P62508
Estrogen-related receptor gamma
OCCC/C(=C(\c1ccc(O)cc1)c1ccc([C@H]2CC[N@@H+](C3CC3)CC2)cc1)c1ccccc1
454.634
5.0485
44.9
8
34
3
2
0.41729
6knr
2.804
2,020
DL9
B
501
ic50
=
56
nM
-7.251812
BindingDB
IC50=56.0nM
P62508
Estrogen-related receptor gamma
OCCC/C(=C(\c1ccc(O)cc1)c1ccc([C@H]2CC[N@@H+](C3CC3)CC2)cc1)c1ccccc1
454.634
5.0485
44.9
8
34
3
2
0.41729
6knz
2.475
2,019
DN0
B
506
kd
=
1.26
uM
-5.899629
MOAD
Kd=1.26uM
P81947,Q6B856
Tubulin alpha-1B chain,Tubulin beta-2B chain
O=C(Cc1ccc(-c2ccc(OCC[NH+]3CCOCC3)cc2)cn1)NCc1ccccc1
432.544
1.9014
64.89
9
32
2
4
0.542222
6knz
2.475
2,019
DN0
D
504
kd
=
1.26
uM
-5.899629
MOAD
Kd=1.26uM
P81947,Q6B856
Tubulin alpha-1B chain,Tubulin beta-2B chain
O=C(Cc1ccc(-c2ccc(OCC[NH+]3CCOCC3)cc2)cn1)NCc1ccccc1
432.544
1.9014
64.89
9
32
2
4
0.542222
6kot
2.149
2,019
DQ0
A
701
ki
=
4.96
nM
-8.304518
MOAD
Ki=4.96nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(COc2cccc(OCCCC(=O)[O-])c2)n1
427.868
2.4493
136.41
9
30
2
8
0.4966
6kot
2.149
2,019
DQ0
B
701
ki
=
4.96
nM
-8.304518
MOAD
Ki=4.96nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(COc2cccc(OCCCC(=O)[O-])c2)n1
427.868
2.4493
136.41
9
30
2
8
0.4966
6kp2
1.973
2,019
DQ3
A
702
ki
=
1.16
nM
-8.935542
MOAD
Ki=1.16nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2ccccc2)n1
354.841
3.973
87.05
6
25
2
5
0.653757
6kp2
1.973
2,019
DQ3
B
702
ki
=
1.16
nM
-8.935542
MOAD
Ki=1.16nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2ccccc2)n1
354.841
3.973
87.05
6
25
2
5
0.653757
6kp7
1.97
2,019
DQ9
A
703
ki
=
0.41
nM
-9.387216
MOAD
Ki=0.41nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCC(=O)[O-])c2)n1
427.868
2.1017
136.41
9
30
2
8
0.495129
6kp7
1.97
2,019
DQ9
B
703
ki
=
0.41
nM
-9.387216
MOAD
Ki=0.41nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCC(=O)[O-])c2)n1
427.868
2.1017
136.41
9
30
2
8
0.495129
6kpr
2.1
2,019
DQF
A
703
ki
=
0.98
nM
-9.008774
MOAD
Ki=0.98nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCCCC(=O)[O-])c2)n1
455.922
2.8819
136.41
11
32
2
8
0.420897
6kpr
2.1
2,019
DQF
B
703
ki
=
0.98
nM
-9.008774
MOAD
Ki=0.98nM
D9N170,D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase,Bifunctional dihydrofolate reductase-thymidylate synthase
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCCCC(=O)[O-])c2)n1
455.922
2.8819
136.41
11
32
2
8
0.420897
6kro
1.9
2,020
DU9
A
1201
ic50
=
39.2
nM
-7.406714
MOAD
ic50=39.2nM
Q9H2K2,Q9H2K2
Tankyrase-2,Tankyrase-2
C[C@@H]1CN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)C[C@H](C)O1
510.614
2.4196
85.01
2
37
1
7
0.664354
6kxx
1.95
2,020
T02
A
501
ec50
=
660
nM
-6.180456
BindingDB
EC50=660nM
Q07869
Peroxisome proliferator-activated receptor alpha
Cc1cc(C(=O)[O-])c2c(C(C)C)nn(-c3ccc(Cl)cc3)c2n1
328.779
2.86922
70.84
3
23
0
5
0.74087
6kxy
2.0
2,020
T06
A
501
ec50
=
1,530
nM
-5.815309
BindingDB
EC50=1530nM
Q07869
Peroxisome proliferator-activated receptor alpha
CCc1cc(C(=O)[O-])c2c(C(CC)CC)nn(-c3ccc(F)cc3)c2n1
354.405
3.3891
70.84
6
26
0
5
0.680207
6kya
2.89
2,020
DY3
A
901
kd
=
225
nM
-6.647817
BindingDB
IC50=30nM,Kd=225nM
Q9NR97,Q9NR97
Toll-like receptor 8,Toll-like receptor 8
CSc1nnc(CCCO)n1-c1cc(C)c(C)c(C)c1
291.42
2.83936
50.94
5
20
1
5
0.860694
6kya
2.89
2,020
DY3
B
901
kd
=
225
nM
-6.647817
BindingDB
IC50=30nM,Kd=225nM
Q9NR97,Q9NR97
Toll-like receptor 8,Toll-like receptor 8
CSc1nnc(CCCO)n1-c1cc(C)c(C)c(C)c1
291.42
2.83936
50.94
5
20
1
5
0.860694
6kyp
2.86
2,020
E0O
B
504
ec50
=
55,000
nM
-4.259637
BindingDB
EC50=55000nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC(C)(Oc1ccc(Cl)cc1)C(=O)[O-]
213.64
1.2473
49.36
3
14
0
3
0.759419
6kz5
4.45
2,020
E4L
B
301
kd
=
1,510
nM
-5.821023
BindingDB
EC50=0.2780nM,Kd=1510nM
P22736,P22736
Nuclear receptor subfamily 4 group A member 1,Nuclear receptor subfamily 4 group A member 1
CCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCC
322.401
3.7466
83.83
10
23
2
5
0.389253
6kzc
2.0
2,019
DZC
A
901
ic50
=
11.46
nM
-7.940815
MOAD
ic50=11.46nM
Q16288
NT-3 growth factor receptor
Cc1c(C#Cc2cnc3cnccn23)cccc1C(=O)Nc1cc(N2CC[NH+](C)CC2)cc(C(F)(F)F)c1
519.551
3.04332
66.97
3
38
2
5
0.408737
6kzd
1.708
2,019
DZ6
A
901
ic50
=
2.95
nM
-8.530178
MOAD
ic50=2.95nM
Q16288
NT-3 growth factor receptor
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(C(C)C)cc(N2CC[NH+](C)CC2)c1
584.748
4.39712
92.99
5
44
3
6
0.210502
6kzp
NMR
2,019
DZR
A
2307
ic50
=
37
nM
-7.431798
BindingDB
IC50=37nM
O43497
Voltage-dependent T-type calcium channel subunit alpha-1G,Voltage-dependent T-type calcium channel subunit alpha-1G
CC(C)(C)NC(=O)C[N@H+]1CC[C@H](CNC(=O)c2cc(F)cc(Cl)c2)CC1
384.903
1.4185
62.64
5
26
3
2
0.718595
6kzv
2.4
2,020
E0F
A
301
ic50
=
5.4
uM
-5.267606
MOAD
ic50=5.4uM
P0AES6
DNA gyrase subunit B
C[N@H+](Cc1ccccc1NC(=O)c1cc2ccccc2[nH]c1=O)C1CCCCC1
390.507
3.1278
66.4
5
29
3
2
0.626634
6kzx
2.1
2,020
E0L
A
301
ic50
=
0.2
uM
-6.69897
MOAD
ic50=0.2uM
P0AES6
DNA gyrase subunit B
CNc1cccc2cc(C(=O)Nc3cccc(C(=O)[O-])c3)c(=O)[nH]c12
336.327
1.1856
114.12
4
25
3
5
0.661924
6kzz
2.0
2,020
E0R
A
301
ic50
=
0.0017
uM
-8.769551
MOAD
ic50=0.0017uM
P0AES6
DNA gyrase subunit B
CNc1cccc2cc(C(=O)Nc3ccc(C(=O)[O-])cc3)c(=O)[nH]c12
336.327
1.1856
114.12
4
25
3
5
0.661924
6l04
2.21
2,020
32I
U
301
ki
=
42
nM
-7.376751
BindingDB
Ki=42nM
P00749
Urokinase-type plasminogen activator
COc1ncc(-c2nc(C(=O)NC(N)=[NH2+])c(N)nc2N2CCCCCC2)c(OC)n1
416.466
-1.283
179.99
5
30
4
9
0.338363
6l05
2.49
2,020
50I
U
301
ki
=
183
nM
-6.737549
BindingDB
Ki=183nM,IC50=530nM
P00749
Urokinase-type plasminogen activator
NC(=[NH2+])NC(=O)c1nc(-c2cc3ccccc3o2)c(N2CCCCCC2)nc1N
394.459
0.656
148.89
3
29
4
6
0.376367
6l11
2.05
2,020
E2C
A
401
ic50
=
705
nM
-6.151811
MOAD
ic50=705.0nM
P11309
Serine/threonine-protein kinase pim-1
CC[NH+](CC)CCCCCN1c2ccccc2Oc2ccc(Cl)cc21
359.921
4.6788
16.91
8
25
1
2
0.689082
6l12
1.87
2,020
E2R
A
401
ic50
=
162
nM
-6.790485
MOAD
ic50=162.0nM
P11309
Serine/threonine-protein kinase pim-1
[NH3+][C@H]1CC[C@H](CN2c3ccccc3Oc3ccc(Cl)cc32)CC1
329.851
4.3845
40.11
2
23
1
2
0.887518
6l13
2.24
2,020
E2F
A
401
ic50
=
241.7
nM
-6.616723
MOAD
ic50=241.7nM
P11309
Serine/threonine-protein kinase pim-1
Clc1ccc2c(c1)N(CCC1CC[NH2+]CC1)c1ccccc1O2
329.851
3.9473
29.08
3
23
1
2
0.923515
6l14
1.95
2,020
E2L
A
401
ic50
=
181.5
nM
-6.741123
MOAD
ic50=181.5nM
P11309
Serine/threonine-protein kinase pim-1
Clc1ccc2c(c1)N(CCC[C@@H]1CCC[NH2+]C1)c1ccccc1O2
343.878
4.3374
29.08
4
24
1
2
0.89441
6l16
2.1
2,020
E2U
A
401
ic50
=
1.7
nM
-8.769551
MOAD
ic50=1.7nM
P11309
Serine/threonine-protein kinase pim-1
[NH3+]CC[N@H+]1CC[C@H](CCN2c3ccncc3Oc3ccc(Cl)cc32)CC1
374.916
1.9057
57.44
5
26
2
3
0.840066
6l1p
1.231
2,020
E3X
A
101
kd
=
0.31
mM
-3.508638
MOAD
Kd=0.31mM
A8MW92,A8MW92,A8MW92
PHD finger protein 20-like protein 1,PHD finger protein 20-like protein 1,PHD finger protein 20-like protein 1
C[N@@H+]1CC=C(c2ccc(O)cc2)CC1
190.266
0.694
24.67
1
14
2
1
0.669009
6l1p
1.231
2,020
E3X
B
101
kd
=
0.31
mM
-3.508638
MOAD
Kd=0.31mM
A8MW92,A8MW92,A8MW92
PHD finger protein 20-like protein 1,PHD finger protein 20-like protein 1,PHD finger protein 20-like protein 1
C[N@@H+]1CC=C(c2ccc(O)cc2)CC1
190.266
0.694
24.67
1
14
2
1
0.669009
6l1p
1.231
2,020
E3X
C
101
kd
=
0.31
mM
-3.508638
MOAD
Kd=0.31mM
A8MW92
PHD finger protein 20-like protein 1
C[N@@H+]1CC=C(c2ccc(O)cc2)CC1
190.266
0.694
24.67
1
14
2
1
0.669009
6l1p
1.231
2,020
E3X
D
101
kd
=
0.31
mM
-3.508638
MOAD
Kd=0.31mM
A8MW92
PHD finger protein 20-like protein 1
C[N@@H+]1CC=C(c2ccc(O)cc2)CC1
190.266
0.694
24.67
1
14
2
1
0.669009
6l2q
2.3
2,020
E4O
A
702
kd
=
1.36
uM
-5.866461
MOAD
Kd=1.36uM
V7II86
Threonine--tRNA ligase
C[C@@H](O)[C@H]([NH3+])C(=O)NC/C=C/Cn1cnc2cc(Cl)c(Cl)cc2c1=O
386.259
0.367
111.86
6
25
3
5
0.622925
6l2q
2.3
2,020
E4O
B
702
kd
=
1.36
uM
-5.866461
MOAD
Kd=1.36uM
V7II86
Threonine--tRNA ligase
C[C@@H](O)[C@H]([NH3+])C(=O)NC/C=C/Cn1cnc2cc(Cl)c(Cl)cc2c1=O
386.259
0.367
111.86
6
25
3
5
0.622925
6l36
3.301
2,020
F5A
A
504
ki
=
35,000
nM
-4.455932
BindingDB
EC50=30000nM,IC50=>10000nM,Ki=35000nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC(C)(Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)[O-]
317.748
2.4783
66.43
5
22
0
4
0.794575
6l36
3.301
2,020
F5A
B
504
ki
=
35,000
nM
-4.455932
BindingDB
EC50=30000nM,IC50=>10000nM,Ki=35000nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC(C)(Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)[O-]
317.748
2.4783
66.43
5
22
0
4
0.794575
6l37
2.91
2,020
C5F
A
504
ec50
=
900
nM
-6.045757
BindingDB
EC50=900nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC(C)(Oc1ccc([C@@H]2CC2(Cl)Cl)cc1)C(=O)[O-]
288.15
2.2551
49.36
4
18
0
3
0.798409
6l37
2.91
2,020
C5F
B
504
ec50
=
900
nM
-6.045757
BindingDB
EC50=900nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC(C)(Oc1ccc([C@@H]2CC2(Cl)Cl)cc1)C(=O)[O-]
288.15
2.2551
49.36
4
18
0
3
0.798409
6l47
NMR
2,020
E5L
A
1001
ic50
=
200
nM
-6.69897
BindingDB
IC50=200nM
P35610
Sterol O-acyltransferase 1
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
393.568
6.2079
56.79
14
28
1
4
0.381877
6l47
NMR
2,020
E5L
B
1001
ic50
=
200
nM
-6.69897
BindingDB
IC50=200nM
P35610
Sterol O-acyltransferase 1
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
393.568
6.2079
56.79
14
28
1
4
0.381877
6l6e
1.92
2,020
E6L
A
901
ki
=
5
nM
-8.30103
BindingDB
Ki=5.0nM
O76074
cGMP-specific 3',5'-cyclic phosphodiesterase
COc1ccc(CNc2nc(N3CCC[C@H]3CO)ncc2C(=O)NCc2ncccn2)cc1Cl
483.96
2.4318
125.39
9
34
3
9
0.420317
6l6k
1.8
2,020
9HF
A
501
ec50
=
143
nM
-6.844664
BindingDB
EC50=143nM
P19793
Retinoic acid receptor RXR-alpha
Cc1cc2c(cc1-n1nnc3cc(C(=O)[O-])ccc31)C(C)(C)CCC2(C)C
362.453
3.44142
70.84
2
27
0
5
0.700041
6l71
2.109
2,021
NCA
A
401
ic50
=
11,000
nM
-4.958607
BindingDB
IC50=11000nM
Q8IXJ6
NAD-dependent protein deacetylase sirtuin-2
NC(=O)c1cccnc1
122.127
0.1805
55.98
1
9
1
2
0.577263
6l88
3.0
2,020
E6R
A
1001
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P08235
Mineralocorticoid receptor
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn(CCO)c1-c1ccccc1C(F)(F)F
466.481
4.13042
88.4
6
32
2
5
0.571902
6l88
3.0
2,020
E6R
B
1001
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P08235
Mineralocorticoid receptor
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn(CCO)c1-c1ccccc1C(F)(F)F
466.481
4.13042
88.4
6
32
2
5
0.571902
6l88
3.0
2,020
E6R
C
1001
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P08235
Mineralocorticoid receptor
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn(CCO)c1-c1ccccc1C(F)(F)F
466.481
4.13042
88.4
6
32
2
5
0.571902
6l88
3.0
2,020
E6R
D
1001
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P08235,P08235
Mineralocorticoid receptor,Mineralocorticoid receptor
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn(CCO)c1-c1ccccc1C(F)(F)F
466.481
4.13042
88.4
6
32
2
5
0.571902
6l89
2.1
2,020
E7C
A
501
ki
=
2.64
uM
-5.578396
MOAD
Ki=2.64uM
P37231
Peroxisome proliferator-activated receptor gamma
COC(=O)[C@]1(Cc2ccc(O)c(CC=C(C)C)c2)OC(=O)C(O)=C1c1ccc(O)cc1
424.449
3.5869
113.29
6
31
3
7
0.479695
6l89
2.1
2,020
E7C
B
501
ki
=
2.64
uM
-5.578396
MOAD
Ki=2.64uM
P37231
Peroxisome proliferator-activated receptor gamma
COC(=O)[C@]1(Cc2ccc(O)c(CC=C(C)C)c2)OC(=O)C(O)=C1c1ccc(O)cc1
424.449
3.5869
113.29
6
31
3
7
0.479695
6l96
3.2
2,020
P7F
A
501
ec50
=
1
nM
-9
BindingDB
EC50=1nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(=O)[O-]
489.548
4.2194
97.09
13
36
0
8
0.257646
6l96
3.2
2,020
P7F
B
501
ec50
=
1
nM
-9
BindingDB
EC50=1nM
Q07869
Peroxisome proliferator-activated receptor alpha
CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(=O)[O-]
489.548
4.2194
97.09
13
36
0
8
0.257646
6lb5
2.4
2,020
E80
A
501
ki
=
182
nM
-6.739929
BindingDB
Ki=182nM,EC50=19nM
P19793
Retinoic acid receptor RXR-alpha
CCN(c1ccc(C(C)C)c(OCC(C)C)c1)c1ccc(C(=O)[O-])cn1
355.458
3.7613
65.49
8
26
0
5
0.721183
6lb5
2.4
2,020
E80
C
501
ki
=
182
nM
-6.739929
BindingDB
Ki=182nM,EC50=19nM
P19793
Retinoic acid receptor RXR-alpha
CCN(c1ccc(C(C)C)c(OCC(C)C)c1)c1ccc(C(=O)[O-])cn1
355.458
3.7613
65.49
8
26
0
5
0.721183
6lb6
2.4
2,020
E8O
A
501
ec50
=
169
nM
-6.772113
BindingDB
EC50=169nM
P19793
Retinoic acid receptor RXR-alpha
CCN(c1ccc(OCC(C)C)c(C(C)C)c1)c1ccc(C(=O)[O-])cn1
355.458
3.7613
65.49
8
26
0
5
0.721183
6ld2
1.4
2,020
KY3
A
903
ic50
=
246.6
uM
-3.608007
MOAD
ic50=246.6uM
A0A024B7W1
RNA-directed RNA polymerase NS5
CO[C@H]1C[C@H](OC)[C@H](c2cccs2)C[C@@H]1C(=O)[O-]
269.342
1.0216
58.59
4
18
0
5
0.818641
6leg
2.603
2,021
SJ5
A
701
ki
=
12
nM
-7.920819
BindingDB
Ki=12nM
P05804,P05804
Beta-D-glucuronidase,Beta-D-glucuronidase
O=C([O-])[C@H]1C[NH2+]C[C@@H](O)[C@@H]1O
161.157
-4.3487
97.2
1
11
3
4
0.361841
6leg
2.603
2,021
SJ5
B
701
ki
=
12
nM
-7.920819
BindingDB
Ki=12nM
P05804,P05804
Beta-D-glucuronidase,Beta-D-glucuronidase
O=C([O-])[C@H]1C[NH2+]C[C@@H](O)[C@@H]1O
161.157
-4.3487
97.2
1
11
3
4
0.361841
6leg
2.603
2,021
SJ5
C
701
ki
=
12
nM
-7.920819
BindingDB
Ki=12nM
P05804,P05804
Beta-D-glucuronidase,Beta-D-glucuronidase
O=C([O-])[C@H]1C[NH2+]C[C@@H](O)[C@@H]1O
161.157
-4.3487
97.2
1
11
3
4
0.361841
6leg
2.603
2,021
SJ5
D
701
ki
=
12
nM
-7.920819
BindingDB
Ki=12nM
P05804,P05804
Beta-D-glucuronidase,Beta-D-glucuronidase
O=C([O-])[C@H]1C[NH2+]C[C@@H](O)[C@@H]1O
161.157
-4.3487
97.2
1
11
3
4
0.361841
6leh
2.0
2,020
EAR
A
935
ic50
=
3.3
nM
-8.481486
MOAD
ic50=3.3nM
Q9R1E6
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
CCOC(=O)Cn1c(C)cc(=O)n2cc(-c3ccc(Cl)cc3)nc12
345.786
2.68792
65.6
4
24
0
6
0.681831