PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6szl
1.45
2,020
M3E
B
604
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTH domain-containing protein 1,YTH domain-containing protein 1
O=c1cc(-c2ccccc2)[nH]c(=O)[nH]1
188.186
0.7302
65.72
1
14
2
2
0.692404
6szn
1.47
2,020
YZM
B
604
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTH domain-containing protein 1,YTH domain-containing protein 1
NC(=O)NC(=O)c1ccccc1
164.164
0.4951
72.19
1
12
2
2
0.63375
6szp
1.76
2,019
M3B
A
300
ki
=
18
uM
-4.744727
MOAD
Ki=18.0uM
O94760
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
COCCN[C@@H]([NH3+])NCCCC[NH3+]
192.307
-2.6404
88.57
9
13
4
3
0.237767
6szr
1.64
2,020
M3Z
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTH domain-containing protein 1
C[N@H+](CC1=NC(=O)NC(=O)C1)Cc1ccccc1
246.29
-0.2178
62.97
4
18
2
2
0.771396
6szt
1.5
2,020
M4Q
A
601
ic50
=
1,926
uM
-2.715344
MOAD
ic50=1926.0uM
Q96MU7
YTHDC1
C[N@H+](CC1=NC(=O)NC(=O)C1)Cc1ccsc1
252.319
-0.1563
62.97
4
17
2
3
0.782165
6szt
1.5
2,020
M4Q
B
601
ic50
=
1,926
uM
-2.715344
MOAD
ic50=1926.0uM
Q96MU7
YTHDC1
C[N@H+](CC1=NC(=O)NC(=O)C1)Cc1ccsc1
252.319
-0.1563
62.97
4
17
2
3
0.782165
6szx
1.17
2,020
M4K
A
601
kd
=
58
uM
-4.236572
MOAD
Kd=58.0uM
Q96MU7
YTHDC1
O=C1CC(C[N@H+](Cc2ccccc2)C2CC2)=NC(=O)N1
272.328
0.3148
62.97
5
20
2
2
0.81036
6szx
1.17
2,020
M4K
B
601
kd
=
58
uM
-4.236572
MOAD
Kd=58.0uM
Q96MU7
YTHDC1
O=C1CC(C[N@H+](Cc2ccccc2)C2CC2)=NC(=O)N1
272.328
0.3148
62.97
5
20
2
2
0.81036
6szy
1.79
2,020
M5N
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
CC(C)C1=NC(=O)N=C2CCCC[C@H]21
192.262
2.8482
41.79
1
14
0
1
0.629454
6t01
1.5
2,020
M4B
A
601
ic50
=
2,057
uM
-2.686766
MOAD
ic50=2057.0uM
Q96MU7
YTH domain-containing protein 1
Cc1[nH]c(=O)nc(-c2ccccc2)c1[N+](=O)[O-]
231.211
1.65352
88.89
2
17
1
4
0.628219
6t01
1.5
2,020
M4B
B
601
ic50
=
2,057
uM
-2.686766
MOAD
ic50=2057.0uM
Q96MU7,Q96MU7
YTH domain-containing protein 1,YTH domain-containing protein 1
Cc1[nH]c(=O)nc(-c2ccccc2)c1[N+](=O)[O-]
231.211
1.65352
88.89
2
17
1
4
0.628219
6t02
1.1
2,020
M5E
A
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
O[C@@H](c1ccccc1)[C@H]1CCC[NH2+]1
178.255
0.4458
36.84
2
13
2
1
0.677405
6t02
1.1
2,020
M5E
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
O[C@@H](c1ccccc1)[C@@H]1CCC[NH2+]1
178.255
0.4458
36.84
2
13
2
1
0.677405
6t03
1.5
2,020
MZY
A
604
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
S=c1[nH]cc[nH]1
100.146
1.07229
31.58
0
6
2
1
0.469416
6t03
1.5
2,020
MZY
B
604
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
S=c1[nH]cc[nH]1
100.146
1.07229
31.58
0
6
2
1
0.469416
6t04
1.5
2,020
M3H
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTH domain-containing protein 1
c1ccc(C2=[NH+]CCN2)cc1
147.201
-0.883
26
1
11
2
1
0.529691
6t05
1.5
2,020
M6H
B
606
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
c1ccc(CC2[NH2+]CC[NH2+]2)cc1
164.252
-1.3044
33.22
2
12
2
0
0.544399
6t06
2.4
2,020
M5H
B
601
ic50
=
2,010
uM
-2.696804
MOAD
ic50=2010.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
c1ccc2c(C3[NH2+]CC[NH2+]3)[nH]nc2c1
190.25
-1.2981
61.9
1
14
3
1
0.514171
6t07
1.5
2,020
M45
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTH domain-containing protein 1,YTH domain-containing protein 1
c1n[nH]c(N[C@H]2CCC[NH2+]2)n1
154.197
-1.1001
70.21
2
11
3
3
0.506147
6t08
1.41
2,020
M5B
A
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
O=S(=O)(Nc1ncc[nH]1)c1cccs1
229.286
1.272
74.85
3
14
2
4
0.831914
6t08
1.41
2,020
M5B
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
O=S(=O)(Nc1ncc[nH]1)c1cccs1
229.286
1.272
74.85
3
14
2
4
0.831914
6t0a
2.02
2,020
M58
A
601
ic50
=
2,040
uM
-2.69037
MOAD
ic50=2040.0uM
Q96MU7
YTHDC1
[NH3+][C@H](S)c1cccnc1
141.219
0.2519
40.53
1
9
2
2
0.427011
6t0a
2.02
2,020
M58
B
601
ic50
=
2,040
uM
-2.69037
MOAD
ic50=2040.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
[NH3+][C@@H](S)c1cccnc1
141.219
0.2519
40.53
1
9
2
2
0.427011
6t0c
2.03
2,020
M4E
A
601
kd
=
22
uM
-4.657577
MOAD
Kd=22.0uM
Q96MU7
YTHDC1
CNC(=O)c1n[nH]c2ccccc12
175.191
0.9225
57.78
1
13
2
2
0.676752
6t0c
2.03
2,020
M4E
B
601
kd
=
22
uM
-4.657577
MOAD
Kd=22.0uM
Q96MU7
YTHDC1
CNC(=O)c1n[nH]c2ccccc12
175.191
0.9225
57.78
1
13
2
2
0.676752
6t0d
1.43
2,020
M4N
A
601
ic50
=
391
uM
-3.407823
MOAD
ic50=391.0uM
Q96MU7
YTHDC1
CNC(=O)c1cc(-c2ccccc2)n[nH]1
201.229
1.4363
57.78
2
15
2
2
0.771909
6t0d
1.43
2,020
M4N
B
601
ic50
=
391
uM
-3.407823
MOAD
ic50=391.0uM
Q96MU7
YTHDC1
CNC(=O)c1cc(-c2ccccc2)n[nH]1
201.229
1.4363
57.78
2
15
2
2
0.771909
6t0j
1.25
2,020
RWZ
A
502
kd
=
3.4
uM
-5.468521
MOAD
Kd=3.4uM
P9WPP3
Methyl-branched lipid omega-hydroxylase
CC(C)=CCCC(C)=CC[NH2+]CC[NH2+][C@H]1[C@H]2C[C@@H]3C[C@H](C2)C[C@H]1C3
332.576
2.6306
33.22
9
24
2
0
0.480689
6t0m
1.51
2,020
GOZ
A
305
ki
=
39
uM
-4.408935
MOAD
Ki=39.0uM
P00760
Cationic trypsin
Nc1cc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H]([NH3+])Cc2ccccc2)cc(N)n1
383.476
-0.2936
141.98
6
28
4
5
0.541974
6t0p
1.19
2,020
M6Q
A
304
ki
=
62
uM
-4.207608
MOAD
Ki=62.0uM
P00760
Cationic Trypsin
Nc1cc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H]([NH3+])Cc2ccccc2)ccn1
368.461
0.1242
115.96
6
27
3
4
0.671604
6t0x
1.36
2,020
M6W
A
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
CNC(=O)[C@H]1CC[NH2+]C1
129.183
-1.6843
45.71
1
9
2
1
0.436047
6t0x
1.36
2,020
M6W
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
CNC(=O)[C@H]1CC[NH2+]C1
129.183
-1.6843
45.71
1
9
2
1
0.436047
6t0z
1.43
2,020
M75
A
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7
YTHDC1
O=S(=O)(NC1CC1)c1c[nH]cn1
187.224
-0.1496
74.85
3
12
2
3
0.690672
6t0z
1.43
2,020
M75
B
601
ic50
>
1,000
uM
-3
MOAD
ic50>1000.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
O=S(=O)(NC1CC1)c1c[nH]cn1
187.224
-0.1496
74.85
3
12
2
3
0.690672
6t10
1.48
2,020
M6Z
A
601
ic50
=
348
uM
-3.458421
MOAD
ic50=348.0uM
Q96MU7
YTHDC1
CNC(=O)c1n[nH]c2ccc(I)cc12
301.087
1.5271
57.78
1
14
2
2
0.78483
6t10
1.48
2,020
M6Z
B
601
ic50
=
348
uM
-3.458421
MOAD
ic50=348.0uM
Q96MU7
YTHDC1
CNC(=O)c1n[nH]c2ccc(I)cc12
301.087
1.5271
57.78
1
14
2
2
0.78483
6t11
1.49
2,020
O2A
B
601
ic50
=
402
uM
-3.395774
MOAD
ic50=402.0uM
Q96MU7,Q96MU7
YTHDC1,YTHDC1
CNC(=O)c1cccc2cc[nH]c12
174.203
1.5275
44.89
1
13
2
1
0.676142
6t12
1.46
2,020
M78
A
601
ic50
=
825
uM
-3.083546
MOAD
ic50=825.0uM
Q96MU7
YTHDC1
CNC(=O)c1ccc2[nH]c(C)c(C)c2c1
202.257
2.14434
44.89
1
15
2
1
0.730786
6t12
1.46
2,020
M78
B
601
ic50
=
825
uM
-3.083546
MOAD
ic50=825.0uM
Q96MU7
YTHDC1
CNC(=O)c1ccc2[nH]c(C)c(C)c2c1
202.257
2.14434
44.89
1
15
2
1
0.730786
6t1s
1.65
2,021
EDK
A
601
ki
=
0.0497
nM
-10.303644
BindingDB
EC50=130nM,Ki=0.049700nM
P37231
Peroxisome proliferator-activated receptor gamma
CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)[O-])cc1)c1ccccn1
494.571
3.6009
94.59
12
37
1
7
0.300822
6t1v
2.21
2,021
EDK
A
4000
ki
=
0.0497
nM
-10.303644
BindingDB
EC50=130nM,Ki=0.049700nM
P37231
Peroxisome proliferator-activated receptor gamma
CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)[O-])cc1)c1ccccn1
494.571
3.6009
94.59
12
37
1
7
0.300822
6t2w
1.7
2,020
M9T
A
1001
ic50
=
0
M
-8
MOAD
ic50=1e-08M
P07333
Macrophage colony-stimulating factor 1 receptor
COc1ccc(Nc2ncc3c(n2)n([C@H]2CC[C@H](O)CC2)c(=O)n3C)c(C)c1
383.452
2.66662
94.2
4
28
2
8
0.719344
6t3q
1.33
2,020
M6Q
H
306
ki
=
379
nM
-6.421361
MOAD
Ki=379.0nM
P00734,P00734
Prothrombin,Prothrombin
Nc1cc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H]([NH3+])Cc2ccccc2)ccn1
368.461
0.1242
115.96
6
27
3
4
0.671604
6t49
1.56
2,020
MH5
A
201
ki
=
0.37
mM
-3.431798
MOAD
Ki=0.37mM
Q04544
Genome polyprotein
Cc1ccc(CNc2cccc(C(=O)[O-])c2)s1
246.311
2.03212
52.16
4
17
1
4
0.897709
6t4a
1.31
2,020
J5K
H
302
ki
=
140
nM
-6.853872
MOAD
Ki=140.0nM
P00734,P00734
Prothrombin,Prothrombin
Nc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H]([NH3+])Cc2ccccc2)cn1
368.461
0.1242
115.96
6
27
3
4
0.671604
6t4g
1.93
2,020
CLR
A
601
ec50
=
20
nM
-7.69897
BindingDB
EC50=20nM
P51449
Nuclear receptor ROR-gamma
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6t4i
1.84
2,020
4F1
A
602
ic50
=
7.8
nM
-8.107905
BindingDB
IC50=7.8nM,EC50=16nM
P51449
Nuclear receptor ROR-gamma
O=C([O-])c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3ccccc23)cc1
443.788
4.4275
75.02
3
31
0
5
0.469296
6t4k
1.89
2,020
4F1
A
602
ic50
=
7.8
nM
-8.107905
BindingDB
IC50=7.8nM,EC50=16nM
P51449
Nuclear receptor ROR-gamma
O=C([O-])c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3ccccc23)cc1
443.788
4.4275
75.02
3
31
0
5
0.469296
6t4n
1.4
2,020
F1A
A
302
kd
=
14
uM
-4.853872
MOAD
Kd=14.0uM
P00918
carbonic anhydrase 2
Cc1cc(C)c(S(N)(=O)=O)c(C)c1
199.275
1.25926
60.16
1
13
1
2
0.739791
6t4o
1.133
2,020
MJ2
A
304
kd
=
18
uM
-4.744727
MOAD
Kd=18.0uM
P00918
carbonic anhydrase 2
Cc1cc(C)cc(S(N)(=O)=O)c1
185.248
0.95084
60.16
1
12
1
2
0.707747
6t4p
1.75
2,020
MHK
A
305
kd
=
2.9
uM
-5.537602
MOAD
Kd=2.9uM
P00918
carbonic anhydrase 2
NS(=O)(=O)c1cccc2ccccc12
207.254
1.4872
60.16
1
14
1
2
0.769654
6t4u
2.0
2,020
4F1
A
803
ic50
=
7.8
nM
-8.107905
BindingDB
IC50=7.8nM,EC50=16nM
P51449
Nuclear receptor ROR-gamma
O=C([O-])c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3ccccc23)cc1
443.788
4.4275
75.02
3
31
0
5
0.469296
6t4x
1.48
2,020
HC3
A
601
ec50
=
20
nM
-7.69897
BindingDB
EC50=20nM
P51449
Nuclear receptor ROR-gamma
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
402.663
6.5036
40.46
5
29
2
2
0.515009
6t4y
1.95
2,020
4F1
A
602
ic50
=
7.8
nM
-8.107905
BindingDB
IC50=7.8nM,EC50=16nM
P51449
Nuclear receptor ROR-gamma
O=C([O-])c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3ccccc23)cc1
443.788
4.4275
75.02
3
31
0
5
0.469296
6t50
1.87
2,020
HC3
A
601
ec50
=
20
nM
-7.69897
BindingDB
EC50=20nM
P51449
Nuclear receptor ROR-gamma
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
402.663
6.5036
40.46
5
29
2
2
0.515009
6t5j
1.6
2,020
MKB
A
201
ic50
=
25
nM
-7.60206
MOAD
ic50=25.0nM
Q9NV35,Q9NV35
Probable 8-oxo-dGTP diphosphatase NUDT15,Probable 8-oxo-dGTP diphosphatase NUDT15
O=C(c1ccc2[nH]ccc2c1)N1CCN(S(=O)(=O)c2ccc3[nH]c(=O)oc3c2)CC1
426.454
1.7491
119.48
3
30
2
5
0.517239
6t5j
1.6
2,020
MKB
B
201
ic50
=
25
nM
-7.60206
MOAD
ic50=25.0nM
Q9NV35,Q9NV35
Probable 8-oxo-dGTP diphosphatase NUDT15,Probable 8-oxo-dGTP diphosphatase NUDT15
O=C(c1ccc2[nH]ccc2c1)N1CCN(S(=O)(=O)c2ccc3[nH]c(=O)oc3c2)CC1
426.454
1.7491
119.48
3
30
2
5
0.517239
6t5p
1.5
2,020
VD8
A
302
kd
=
5.9
uM
-5.229148
MOAD
Kd=5.9uM
O43570
Carbonic anhydrase 12
CC(C)(C)c1cc(C(C)(C)C)cc(S(N)(=O)=O)c1
269.41
2.929
60.16
1
18
1
2
0.851774
6t5p
1.5
2,020
VD8
B
302
kd
=
5.9
uM
-5.229148
MOAD
Kd=5.9uM
O43570
Carbonic anhydrase 12
CC(C)(C)c1cc(C(C)(C)C)cc(S(N)(=O)=O)c1
269.41
2.929
60.16
1
18
1
2
0.851774
6t5p
1.5
2,020
VD8
C
302
kd
=
5.9
uM
-5.229148
MOAD
Kd=5.9uM
O43570
Carbonic anhydrase 12
CC(C)(C)c1cc(C(C)(C)C)cc(S(N)(=O)=O)c1
269.41
2.929
60.16
1
18
1
2
0.851774
6t5p
1.5
2,020
VD8
D
302
kd
=
5.9
uM
-5.229148
MOAD
Kd=5.9uM
O43570
Carbonic anhydrase 12
CC(C)(C)c1cc(C(C)(C)C)cc(S(N)(=O)=O)c1
269.41
2.929
60.16
1
18
1
2
0.851774
6t5q
1.8
2,020
MKQ
A
302
kd
=
0.83
uM
-6.080922
MOAD
Kd=0.83uM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(-c2ccccc2)cc(-c2ccccc2)c1
309.39
3.668
60.16
3
22
1
2
0.802193
6t5q
1.8
2,020
MKQ
B
302
kd
=
0.83
uM
-6.080922
MOAD
Kd=0.83uM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(-c2ccccc2)cc(-c2ccccc2)c1
309.39
3.668
60.16
3
22
1
2
0.802193
6t5q
1.8
2,020
MKQ
C
302
kd
=
0.83
uM
-6.080922
MOAD
Kd=0.83uM
O43570,O43570
Carbonic anhydrase 12,Carbonic anhydrase 12
NS(=O)(=O)c1cc(-c2ccccc2)cc(-c2ccccc2)c1
309.39
3.668
60.16
3
22
1
2
0.802193
6t5w
1.13
2,020
J5K
A
304
ki
=
47
uM
-4.327902
MOAD
Ki=47.0uM
P00760
Cationic Trypsin
Nc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H]([NH3+])Cc2ccccc2)cn1
368.461
0.1242
115.96
6
27
3
4
0.671604
6t6w
1.8
2,020
JL7
A
201
ki
=
0.34
mM
-3.468521
MOAD
Ki=0.34mM
Q04544
Genome polyprotein
O=C([O-])c1csc(-c2ccc(C(F)(F)F)cc2)n1
272.227
2.1924
53.02
2
18
0
4
0.841684
6t6y
1.4
2,020
MQH
A
301
kd
=
232
nM
-6.634512
MOAD
Kd=232.0nM
K4MHV9
BotH
COC(=O)C[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](/[NH+]=C1/NCC(=O)N2CC[C@@H](C)[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1C(C)(C)C)C(C)(C)C)[C@@H](C)c1ccccc1)c1nccs1
824.082
1.5577
201.9
11
58
6
9
0.1821
6t6z
1.7
2,020
MRB
A
301
kd
=
3.2
uM
-5.49485
MOAD
Kd=3.2uM
K4MHV9
BotH
COC(=O)C[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](/[NH+]=C1/NCC(=O)N2CC[C@@H](C)[C@H]2C(=O)N[C@@H](CCSC)C(=O)N[C@H]1C(C)(C)C)C(C)(C)C)[C@@H](C)c1ccccc1)c1nccs1
856.149
1.6548
201.9
13
59
6
10
0.161125
6t70
1.58
2,020
MQZ
A
306
kd
=
459
nM
-6.338187
MOAD
Kd=459.0nM
K4MHV9
BotH
COC(=O)C[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](/[NH+]=C1/NCC(=O)N2CC[C@@H](C)[C@H]2C(=O)N[C@@H](CC[S@@](C)=O)C(=O)N[C@H]1C(C)(C)C)C(C)(C)C)[C@@H](C)c1ccccc1)c1nccs1
872.148
0.6703
218.97
13
60
6
10
0.154735
6t7p
1.416
2,020
MU8
A
314
ki
=
0.97
uM
-6.013228
MOAD
Ki=0.97uM
P03952
Plasma kallikrein
[NH3+][C@@H]1COc2cc(C(=O)N3C[C@@H](c4ccccc4)C[C@H]3C(=O)Nc3cccc(Cl)c3)ccc21
462.957
3.6524
86.28
4
33
2
3
0.620092
6t81
0.98
2,020
MUE
A
302
kd
=
0.77
uM
-6.113509
MOAD
Kd=0.77uM
P00918
carbonic anhydrase 2
NS(=O)(=O)c1ccc2ccccc2c1
207.254
1.4872
60.16
1
14
1
2
0.769654
6t8p
2.02
2,020
MVT
A
501
ic50
=
880
nM
-6.055517
MOAD
ic50=880.0nM
Q8N5Z0,Q8N5Z0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial,Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
CC(C)[C@@H](Cc1nnc(NS(=O)(=O)c2cc(F)cc(F)c2)s1)c1cccc(F)c1
441.5
4.7385
71.95
7
29
1
5
0.574995
6t8p
2.02
2,020
MVT
A
503
ic50
=
880
nM
-6.055517
MOAD
ic50=880.0nM
Q8N5Z0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
CC(C)[C@@H](Cc1nnc(NS(=O)(=O)c2cc(F)cc(F)c2)s1)c1cccc(F)c1
441.5
4.7385
71.95
7
29
1
5
0.574995
6t8p
2.02
2,020
MVT
A
502
ic50
=
880
nM
-6.055517
MOAD
ic50=880.0nM
Q8N5Z0,Q8N5Z0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial,Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
CC(C)[C@@H](Cc1nnc(NS(=O)(=O)c2cc(F)cc(F)c2)s1)c1cccc(F)c1
441.5
4.7385
71.95
7
29
1
5
0.574995
6t8p
2.02
2,020
MVT
B
501
ic50
=
880
nM
-6.055517
MOAD
ic50=880.0nM
Q8N5Z0,Q8N5Z0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial,Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
CC(C)[C@@H](Cc1nnc(NS(=O)(=O)c2cc(F)cc(F)c2)s1)c1cccc(F)c1
441.5
4.7385
71.95
7
29
1
5
0.574995
6t8x
2.81
2,021
B97
A
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6t8x
2.81
2,021
B97
B
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6t8x
2.81
2,021
B97
C
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6t8x
2.81
2,021
B97
D
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6t8x
2.81
2,021
B97
E
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6t8x
2.81
2,021
B97
F
401
ki
=
5
nM
-8.30103
BindingDB
IC50=201nM,Ki=5.0nM
P49137
MAP kinase-activated protein kinase 2
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
374.469
4.36372
66.91
1
27
2
5
0.519336
6tbx
1.3
2,020
N0Z
A
302
ki
=
83
uM
-4.080922
MOAD
Ki=83.0uM
O76290,O76290,O76290
Pteridine reductase,Pteridine reductase,Pteridine reductase
Nc1nc(N)c2c(n1)[nH]c1ccc(O)cc12
215.216
0.9811
113.84
0
16
4
5
0.446034
6tbx
1.3
2,020
N0Z
B
302
ki
=
83
uM
-4.080922
MOAD
Ki=83.0uM
O76290,O76290,O76290
Pteridine reductase,Pteridine reductase,Pteridine reductase
Nc1nc(N)c2c(n1)[nH]c1ccc(O)cc12
215.216
0.9811
113.84
0
16
4
5
0.446034
6tbx
1.3
2,020
N0Z
C
303
ki
=
83
uM
-4.080922
MOAD
Ki=83.0uM
O76290,O76290
Pteridine reductase,Pteridine reductase
Nc1nc(N)c2c(n1)[nH]c1ccc(O)cc12
215.216
0.9811
113.84
0
16
4
5
0.446034
6tbx
1.3
2,020
N0Z
D
302
ki
=
83
uM
-4.080922
MOAD
Ki=83.0uM
O76290,O76290,O76290
Pteridine reductase,Pteridine reductase,Pteridine reductase
Nc1nc(N)c2c(n1)[nH]c1ccc(O)cc12
215.216
0.9811
113.84
0
16
4
5
0.446034
6tca
3.7
2,020
39G
B
401
kd
=
15,400
nM
-4.812479
BindingDB
IC50=>10000nM,Ki=14nM,Kd=15400nM
P49137,Q16539
MAP kinase-activated protein kinase 2,Mitogen-activated protein kinase 14
CCCc1c(C(=O)Nc2cc(S(=O)(=O)N(C)C)ccc2C)cnn1-c1ccccc1
426.542
3.63582
84.3
7
30
1
5
0.625172
6tca
3.7
2,020
39G
D
401
kd
=
15,400
nM
-4.812479
BindingDB
IC50=>10000nM,Ki=14nM,Kd=15400nM
P49137,Q16539
MAP kinase-activated protein kinase 2,Mitogen-activated protein kinase 14
CCCc1c(C(=O)Nc2cc(S(=O)(=O)N(C)C)ccc2C)cnn1-c1ccccc1
426.542
3.63582
84.3
7
30
1
5
0.625172
6tca
3.7
2,020
39G
F
401
kd
=
15,400
nM
-4.812479
BindingDB
IC50=>10000nM,Ki=14nM,Kd=15400nM
P49137,Q16539
MAP kinase-activated protein kinase 2,Mitogen-activated protein kinase 14
CCCc1c(C(=O)Nc2cc(S(=O)(=O)N(C)C)ccc2C)cnn1-c1ccccc1
426.542
3.63582
84.3
7
30
1
5
0.625172
6tca
3.7
2,020
39G
H
401
kd
=
15,400
nM
-4.812479
BindingDB
IC50=>10000nM,Ki=14nM,Kd=15400nM
Q16539,P49137
Mitogen-activated protein kinase 14,MAP kinase-activated protein kinase 2
CCCc1c(C(=O)Nc2cc(S(=O)(=O)N(C)C)ccc2C)cnn1-c1ccccc1
426.542
3.63582
84.3
7
30
1
5
0.625172
6tcu
2.14
2,020
N1Q
A
401
ic50
=
0.018
uM
-7.744727
MOAD
ic50=0.018uM
P49841
Glycogen synthase kinase-3 beta
COCC[N@H+]1CC[C@H](CNC(=O)c2n[nH]c3ccc(-c4cccc(F)c4F)cc23)CC1
429.491
2.1792
71.45
7
31
3
3
0.539257
6td2
2.8
2,020
N2K
A
603
kd
=
9,200
nM
-5.036212
BindingDB
Kd=9200nM,IC50=12000nM
P21836
Acetylcholinesterase
CC[NH+](CC)CCNS(=O)(=O)Cc1ccc(C(F)(F)F)cc1
339.403
1.0495
50.61
8
22
2
2
0.743833
6td2
2.8
2,020
N2K
B
601
kd
=
9,200
nM
-5.036212
BindingDB
Kd=9200nM,IC50=12000nM
P21836
Acetylcholinesterase
CC[NH+](CC)CCNS(=O)(=O)Cc1ccc(C(F)(F)F)cc1
339.403
1.0495
50.61
8
22
2
2
0.743833
6tdc
2.328
2,020
4F1
A
601
ic50
=
130
nM
-6.886057
BindingDB
IC50=130nM
P37231
Peroxisome proliferator-activated receptor gamma
O=C([O-])c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3ccccc23)cc1
443.788
4.4275
75.02
3
31
0
5
0.469296
6tdf
2.01
2,020
N3Q
A
202
kd
=
5
uM
-5.30103
MOAD
Kd=5.0uM
Q4WCU5
Glucosamine 6-phosphate N-acetyltransferase
OCCN(CCO)c1cc(Cl)c(-c2nnc[nH]2)c(Cl)c1
317.176
1.5695
85.27
6
20
3
5
0.752909
6tdg
1.74
2,020
N3W
A
202
kd
=
0.8
uM
-6.09691
MOAD
Kd=0.8uM
Q4WCU5
Glucosamine 6-phosphate N-acetyltransferase
Nc1cccc(-c2nnc[nH]2)c1Cl
194.625
1.7073
67.59
1
13
2
3
0.679492
6tdh
1.58
2,020
N2Z
A
202
kd
=
6
uM
-5.221849
MOAD
Kd=6.0uM
Q4WCU5
Glucosamine 6-phosphate N-acetyltransferase
Clc1ccccc1-c1nnc[nH]1
179.61
2.1251
41.57
1
12
1
2
0.728836
6tdt
1.53
2,020
LXW
H
305
ki
=
1,213
nM
-5.916139
MOAD
Ki=1213.0nM
P00734,P00734
Prothrombin,Prothrombin
[NH3+][C@@H](C(=O)N1CCC[C@H]1C(=O)NCc1ccncc1)C(c1ccccc1)c1ccccc1
429.544
2.1314
89.94
7
32
2
3
0.602939
6te1
3.11
2,020
N4K
A
901
ic50
=
0.19
nM
-9.721246
BindingDB
IC50=0.190000nM
O60341
Lysine-specific histone demethylase 1A
Cn1c(-c2nc(C3CCC3)cn2CCOc2ccc(OC3CC[NH2+]CC3)cc2)cc2sccc21
477.654
4.5544
57.82
8
34
1
6
0.404948
6te1
3.11
2,020
N4K
A
902
ic50
=
0.19
nM
-9.721246
BindingDB
IC50=0.190000nM
O60341
Lysine-specific histone demethylase 1A
Cn1c(-c2nc(C3CCC3)cn2CCOc2ccc(OC3CC[NH2+]CC3)cc2)cc2sccc21
477.654
4.5544
57.82
8
34
1
6
0.404948
6te2
0.922
2,020
N4N
A
401
ki
=
1,466
nM
-5.833866
BindingDB
Ki=1466nM
P19784
Casein kinase II subunit alpha'
O=C([O-])c1cccc(Nc2nc(-c3ccccn3)cs2)c1
296.331
2.3122
77.94
4
21
1
6
0.79904