PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6xvg
2.1
2,020
8L9
C
1006
ec50
=
5,700
nM
-5.244125
BindingDB
EC50=5700nM
Q8N6T7,Q8N6T7,Q8N6T7
NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6
Cc1cc(F)c(Br)cc1NS(=O)(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1C(=O)[O-]
611.274
4.16852
132.47
7
34
2
6
0.412575
6xvg
2.1
2,020
8L9
D
404
ec50
=
5,700
nM
-5.244125
BindingDB
EC50=5700nM
Q8N6T7,Q8N6T7
NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6
Cc1cc(F)c(Br)cc1NS(=O)(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1C(=O)[O-]
611.274
4.16852
132.47
7
34
2
6
0.412575
6xvg
2.1
2,020
8L9
E
705
ec50
=
5,700
nM
-5.244125
BindingDB
EC50=5700nM
Q8N6T7,Q8N6T7,Q8N6T7
NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6
Cc1cc(F)c(Br)cc1NS(=O)(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1C(=O)[O-]
611.274
4.16852
132.47
7
34
2
6
0.412575
6xvg
2.1
2,020
8L9
F
403
ec50
=
5,700
nM
-5.244125
BindingDB
EC50=5700nM
Q8N6T7,Q8N6T7,Q8N6T7,Q8N6T7
NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6,NAD-dependent protein deacetylase sirtuin-6
Cc1cc(F)c(Br)cc1NS(=O)(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1C(=O)[O-]
611.274
4.16852
132.47
7
34
2
6
0.412575
6xvk
1.99
2,020
O3E
A
1201
ic50
=
0.538
uM
-6.269218
MOAD
ic50=0.538uM
P35968
Vascular endothelial growth factor receptor 2
CC#CC1=Nc2ccc(NC(=O)Cc3ncc(Oc4ccnc5cc(OC)ccc45)cc3OC)cc2C(C)(C)O1
536.588
5.9391
104.16
7
40
1
8
0.291623
6xvp
2.65
2,020
D0Z
A
802
ic50
=
8
nM
-8.09691
BindingDB
IC50=8.0nM
P08473
Neprilysin
CS(=O)(=O)N[C@@H](CCCC[NH3+])C(=O)NC[C@H](CC1(C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)[O-])CCCC1)C(=O)[O-]
583.684
-3.0678
232.5
17
40
5
9
0.116914
6xvw
2.0
2,020
O3H
A
1111
ic50
=
9.3
nM
-8.031517
BindingDB
IC50=9.3nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
O=c1[nH]c(SCC[NH+]2CCN(c3ccccn3)CC2)nc2ccccc12
368.486
0.8153
66.32
5
26
2
5
0.515522
6xvw
2.0
2,020
O3H
B
1105
ic50
=
9.3
nM
-8.031517
BindingDB
IC50=9.3nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
O=c1[nH]c(SCC[NH+]2CCN(c3ccccn3)CC2)nc2ccccc12
368.486
0.8153
66.32
5
26
2
5
0.515522
6xxk
1.65
2,020
SPD
A
401
kd
=
4
uM
-5.39794
MOAD
Kd=4.0uM
P49366,P49366
Deoxyhypusine synthase,Deoxyhypusine synthase
[NH3+]CCCC[NH2+]CCC[NH3+]
148.274
-2.7961
71.89
7
10
3
0
0.326519
6xxk
1.65
2,020
SPD
B
401
kd
=
4
uM
-5.39794
MOAD
Kd=4.0uM
P49366,P49366
Deoxyhypusine synthase,Deoxyhypusine synthase
[NH3+]CCCC[NH2+]CCC[NH3+]
148.274
-2.7961
71.89
7
10
3
0
0.326519
6xxt
1.05
2,020
O42
X
302
ki
=
3.7
nM
-8.431798
MOAD
Ki=3.7nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(C(=O)N2CCN(C(=O)c3ccccc3)CC2)cc1
373.434
0.9322
100.78
3
26
1
4
0.864812
6xxy
2.09
2,020
O45
A
404
ic50
=
2.9
uM
-5.537602
MOAD
ic50=2.9uM
P43860,P43860
3-isopropylmalate dehydrogenase,3-isopropylmalate dehydrogenase
C=C(C)CONC(=O)C(=O)[O-]
158.133
-1.6398
78.46
3
11
1
4
0.303327
6xxy
2.09
2,020
O45
B
402
ic50
=
2.9
uM
-5.537602
MOAD
ic50=2.9uM
P43860,P43860
3-isopropylmalate dehydrogenase,3-isopropylmalate dehydrogenase
C=C(C)CONC(=O)C(=O)[O-]
158.133
-1.6398
78.46
3
11
1
4
0.303327
6xya
1.35
2,020
MGP
B
1901
kd
=
138
uM
-3.860121
MOAD
Kd=138.0uM
I0DF35
RNA-dependent RNA polymerase
C[n+]1cn([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21
534.184
-5.4342
301.41
8
33
4
17
0.181306
6xze
1.54
2,020
O4Z
A
302
ki
=
24.6
nM
-7.609065
MOAD
Ki=24.6nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccccc2F)cc1
367.426
0.3582
117.9
7
25
4
3
0.529188
6xze
1.54
2,020
O4Z
B
302
ki
=
24.6
nM
-7.609065
MOAD
Ki=24.6nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccccc2F)cc1
367.426
0.3582
117.9
7
25
4
3
0.529188
6xzh
2.372
2,021
VDX
A
4001
kd
=
1,200
nM
-5.920819
BindingDB
Kd=1200nM,EC50=5.5nM
Q9PTN2
Vitamin D3 receptor A
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
6xzi
2.1
2,021
VDX
A
501
kd
=
1,200
nM
-5.920819
BindingDB
Kd=1200nM,EC50=5.5nM
Q9PTN2
Vitamin D3 receptor A
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
6xzj
2.1
2,021
VDX
A
501
kd
=
1,200
nM
-5.920819
BindingDB
Kd=1200nM,EC50=5.5nM
Q9PTN2
Vitamin D3 receptor A
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
6xzk
2.0
2,021
VDX
A
501
kd
=
1,200
nM
-5.920819
BindingDB
Kd=1200nM,EC50=5.5nM
Q9PTN2
Vitamin D3 receptor A
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
6xzo
1.44
2,020
O55
A
302
ki
=
138.4
nM
-6.858864
MOAD
Ki=138.4nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccc(Br)cc2O)cc1
444.331
0.6872
138.13
7
26
5
4
0.40128
6xzo
1.44
2,020
O55
B
302
ki
=
138.4
nM
-6.858864
MOAD
Ki=138.4nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccc(Br)cc2O)cc1
444.331
0.6872
138.13
7
26
5
4
0.40128
6xzs
1.53
2,020
O5K
A
302
ki
=
724.7
nM
-6.139842
MOAD
Ki=724.7nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccc(F)cc2)cc1
367.426
0.3582
117.9
7
25
4
3
0.529188
6xzs
1.53
2,020
O5K
B
302
ki
=
724.7
nM
-6.139842
MOAD
Ki=724.7nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1ccc(NC(=O)NCC[NH2+]Cc2ccc(F)cc2)cc1
367.426
0.3582
117.9
7
25
4
3
0.529188
6xzv
2.3
2,021
VDX
A
501
kd
=
1,200
nM
-5.920819
BindingDB
Kd=1200nM,EC50=5.5nM
Q9PTN2
Vitamin D3 receptor A
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
416.646
5.7047
60.69
6
30
3
3
0.519992
6xzx
1.55
2,020
O5H
A
302
ki
=
928.3
nM
-6.032312
MOAD
Ki=928.3nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccccc2)c1
349.436
0.2191
117.9
7
24
4
3
0.535502
6xzx
1.55
2,020
O5H
B
302
ki
=
928.3
nM
-6.032312
MOAD
Ki=928.3nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccccc2)c1
349.436
0.2191
117.9
7
24
4
3
0.535502
6xzy
1.66
2,020
O5N
A
302
ki
=
728
nM
-6.137869
MOAD
Ki=728.0nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccccc2F)c1
367.426
0.3582
117.9
7
25
4
3
0.529188
6xzy
1.66
2,020
O5N
B
302
ki
=
728
nM
-6.137869
MOAD
Ki=728.0nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccccc2F)c1
367.426
0.3582
117.9
7
25
4
3
0.529188
6y00
1.37
2,020
O5T
A
302
ki
=
653.8
nM
-6.184555
MOAD
Ki=653.8nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccc(Br)cc2O)c1
444.331
0.6872
138.13
7
26
5
4
0.40128
6y00
1.37
2,020
O5T
B
302
ki
=
653.8
nM
-6.184555
MOAD
Ki=653.8nM
P00915
Carbonic anhydrase 1
NS(=O)(=O)c1cccc(NC(=O)NCC[NH2+]Cc2ccc(Br)cc2O)c1
444.331
0.6872
138.13
7
26
5
4
0.40128
6y0f
2.924
2,021
356
A
806
ic50
=
89
nM
-7.05061
BindingDB
IC50=89nM
Q12884
Prolyl endopeptidase FAP
CC#CCn1c(N2CCC[C@@H]([NH3+])C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
473.561
0.43062
118.48
4
35
1
9
0.429628
6y0f
2.924
2,021
356
B
809
ic50
=
89
nM
-7.05061
BindingDB
IC50=89nM
Q12884
Prolyl endopeptidase FAP
CC#CCn1c(N2CCC[C@@H]([NH3+])C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
473.561
0.43062
118.48
4
35
1
9
0.429628
6y0f
2.924
2,021
356
C
806
ic50
=
89
nM
-7.05061
BindingDB
IC50=89nM
Q12884
Prolyl endopeptidase FAP
CC#CCn1c(N2CCC[C@@H]([NH3+])C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
473.561
0.43062
118.48
4
35
1
9
0.429628
6y0f
2.924
2,021
356
D
808
ic50
=
89
nM
-7.05061
BindingDB
IC50=89nM
Q12884
Prolyl endopeptidase FAP
CC#CCn1c(N2CCC[C@@H]([NH3+])C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
473.561
0.43062
118.48
4
35
1
9
0.429628
6y55
2.38
2,020
O9Q
A
901
ki
=
2.23
uM
-5.651695
MOAD
Ki=2.23uM
P00489
Glycogen phosphorylase, muscle form
Cc1cccc(-c2cc(=O)c3c(O)cc(O)cc3o2)c1
268.268
3.17962
70.67
1
20
2
4
0.710721
6y5a
NMR
2,020
SRO
A
501
ki
=
361
nM
-6.442493
BindingDB
Ki=361nM,EC50=3400nM
P23979,P23979
5-hydroxytryptamine receptor 3A,5-hydroxytryptamine receptor 3A
[NH3+]CCc1c[nH]c2ccc(O)cc12
177.227
0.6579
63.66
2
13
3
1
0.619537
6y5a
NMR
2,020
SRO
B
501
ki
=
361
nM
-6.442493
BindingDB
Ki=361nM,EC50=3400nM
P23979,P23979
5-hydroxytryptamine receptor 3A,5-hydroxytryptamine receptor 3A
[NH3+]CCc1c[nH]c2ccc(O)cc12
177.227
0.6579
63.66
2
13
3
1
0.619537
6y5a
NMR
2,020
SRO
C
501
ki
=
361
nM
-6.442493
BindingDB
Ki=361nM,EC50=3400nM
P23979,P23979
5-hydroxytryptamine receptor 3A,5-hydroxytryptamine receptor 3A
[NH3+]CCc1c[nH]c2ccc(O)cc12
177.227
0.6579
63.66
2
13
3
1
0.619537
6y5a
NMR
2,020
SRO
D
501
ki
=
361
nM
-6.442493
BindingDB
Ki=361nM,EC50=3400nM
P23979,P23979
5-hydroxytryptamine receptor 3A,5-hydroxytryptamine receptor 3A
[NH3+]CCc1c[nH]c2ccc(O)cc12
177.227
0.6579
63.66
2
13
3
1
0.619537
6y5a
NMR
2,020
SRO
E
501
ki
=
361
nM
-6.442493
BindingDB
Ki=361nM,EC50=3400nM
P23979,P23979
5-hydroxytryptamine receptor 3A,5-hydroxytryptamine receptor 3A
[NH3+]CCc1c[nH]c2ccc(O)cc12
177.227
0.6579
63.66
2
13
3
1
0.619537
6y5c
2.4
2,020
O9T
A
901
ki
=
21.36
uM
-4.670399
MOAD
Ki=21.36uM
P00489
Glycogen phosphorylase, muscle form
Cc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1
268.268
3.17962
70.67
1
20
2
4
0.710721
6y5m
2.011
2,020
O9W
A
913
ic50
=
9.6
nM
-8.017729
MOAD
ic50=9.6nM
Q9R1E6
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CC[N@H+](Cc3ccc(F)cc3)C[C@H]2C)n1
469.972
2.15132
68.35
6
33
1
5
0.561644
6y5o
2.33
2,020
O9Z
A
901
ki
=
3.89
uM
-5.41005
MOAD
Ki=3.89uM
P00489
Glycogen phosphorylase, muscle form
O=c1cc(-c2ccc(F)cc2)oc2cc(O)cc(O)c12
272.231
3.0103
70.67
1
20
2
4
0.713992
6y7l
1.8
2,021
QMG
A
301
kd
=
33
nM
-7.481486
BindingDB
Kd=33nM
Q9H8M2
Bromodomain-containing protein 9
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12
333.391
3.40452
63.47
4
25
1
4
0.74434
6y7w
1.39
2,020
OFW
A
407
kd
=
57.8
uM
-4.238072
MOAD
Kd=57.8uM
P47811
Mitogen-activated protein kinase 14
C[C@]1(C(=O)NC[C@]2([NH3+])[C@@H]3C[C@H]4C[C@H](C[C@@H]2C4)C3)CN(S(=O)(=O)c2ccc(N3C(=O)CCC3=O)nc2)CCO1
546.67
0.0676
153.62
6
38
2
7
0.47874
6y81
1.54
2,020
OG5
A
412
kd
=
25.1
uM
-4.600326
MOAD
Kd=25.1uM
P47811
Mitogen-activated protein kinase 14
[NH3+][C@]1(CNC(=O)C[C@@H](NS(=O)(=O)c2ccc(N3C(=O)CCC3=O)nc2)c2ccccc2)[C@H]2C[C@@H]3C[C@H](C2)C[C@H]1C3
566.704
1.6977
153.18
9
40
3
6
0.392884
6y85
1.58
2,020
OG8
A
401
kd
=
112,000
nM
-3.950782
BindingDB
Kd=112000nM
P47811
Mitogen-activated protein kinase 14
NC(=[NH2+])NC[C@]12C[C@H]3C[C@H](C[C@H](C3)C1)C2
208.329
-0.1338
63.64
2
15
3
0
0.436971
6y8n
1.5
2,020
OGH
A
401
ic50
=
9
nM
-8.045757
MOAD
ic50=9.0nM
G7CIP8,G7CIP8
DNA gyrase subunit B,DNA gyrase subunit B
CNc1cc(F)cc2c1[nH]c1nc(Oc3cnc(C)nc3)nc(N3C[C@@H]4[C@@H]([NH3+])[C@@H]4C3)c12
421.46
1.85912
119.49
4
31
3
7
0.460047
6y8n
1.5
2,020
OGH
B
401
ic50
=
9
nM
-8.045757
MOAD
ic50=9.0nM
G7CIP8,G7CIP8
DNA gyrase subunit B,DNA gyrase subunit B
CNc1cc(F)cc2c1[nH]c1nc(Oc3cnc(C)nc3)nc(N3C[C@@H]4[C@@H]([NH3+])[C@@H]4C3)c12
421.46
1.85912
119.49
4
31
3
7
0.460047
6y9r
2.08
2,020
OH8
A
401
ic50
=
0.009
uM
-8.045757
MOAD
ic50=0.009uM
P49841
Glycogen synthase kinase-3 beta
COCC[N@H+]1CC[C@H](CNC(=O)c2n[nH]c3ccc(-c4cncc(OC(C)C)c4)cc23)CC1
452.579
2.0832
93.57
9
33
3
5
0.462291
6y9s
2.03
2,020
OHK
A
401
ic50
=
0.072
uM
-7.142668
MOAD
ic50=0.072uM
P49841,P49841
Glycogen synthase kinase-3 beta,Glycogen synthase kinase-3 beta
CC(C)Oc1cncc(-c2ccc3cnc(C(=O)NCC4CCOCC4)n3c2)c1
394.475
3.3399
77.75
6
29
1
6
0.693802
6y9s
2.03
2,020
OHK
B
401
ic50
=
0.072
uM
-7.142668
MOAD
ic50=0.072uM
P49841,P49841
Glycogen synthase kinase-3 beta,Glycogen synthase kinase-3 beta
CC(C)Oc1cncc(-c2ccc3cnc(C(=O)NCC4CCOCC4)n3c2)c1
394.475
3.3399
77.75
6
29
1
6
0.693802
6ya5
2.0
2,020
LU2
A
203
ic50
=
0.072
uM
-7.142668
MOAD
ic50=0.072uM
C3W5X6
Polymerase acidic protein,Polymerase acidic protein
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
286.239
2.2824
111.13
1
21
4
6
0.510622
6ya6
1.44
2,020
0SX
A
601
ic50
=
3.4
nM
-8.468521
BindingDB
IC50=3.4nM
O00311
Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase
O=c1[nH]c([C@@H]2CCC[NH2+]2)nc2c1oc1ccc(Cl)cc12
290.73
1.721
75.5
1
20
2
3
0.716389
6yao
2.0
2,020
OJ2
A
602
ic50
=
1.5
uM
-5.823909
MOAD
ic50=1.5uM
E3T1W8
Cytokinin dehydrogenase 4
O=C(Nc1cccc(OC(F)(F)F)c1)Nc1ccccc1CCO
340.301
3.764
70.59
5
24
3
3
0.775986
6yap
1.9
2,020
OHZ
A
604
ic50
=
0.37
uM
-6.431798
MOAD
ic50=0.37uM
E3T1W8
Cytokinin dehydrogenase 4
O=C(Nc1cc(Cl)cc(OC(F)(F)F)c1)Nc1ccccc1CCO
374.746
4.4174
70.59
5
25
3
3
0.725293
6yaq
1.95
2,020
OHZ
A
601
ic50
=
0.059
uM
-7.229148
MOAD
ic50=0.059uM
A0A1D6QQD6
Cytokinin dehydrogenase 8
O=C(Nc1cc(Cl)cc(OC(F)(F)F)c1)Nc1ccccc1CCO
374.746
4.4174
70.59
5
25
3
3
0.725293
6ybg
2.1
2,020
OJT
A
401
ki
=
13
nM
-7.886057
MOAD
Ki=13.0nM
Q07820,Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1,Induced myeloid leukemia cell differentiation protein Mcl-1
COc1ccccc1C[C@@H](Oc1ncnc2sc(-c3cccc(Cl)c3)c(-c3ccc(OCC[NH+]4CCN(C)CC4)c(Cl)c3C)c12)C(=O)[O-]
707.68
4.59822
101.28
12
48
1
9
0.20111
6ybg
2.1
2,020
OJT
B
401
ki
=
13
nM
-7.886057
MOAD
Ki=13.0nM
Q07820,Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1,Induced myeloid leukemia cell differentiation protein Mcl-1
COc1ccccc1C[C@@H](Oc1ncnc2sc(-c3cccc(Cl)c3)c(-c3ccc(OCC[NH+]4CCN(C)CC4)c(Cl)c3C)c12)C(=O)[O-]
707.68
4.59822
101.28
12
48
1
9
0.20111
6ybj
2.5
2,020
OJW
A
403
ki
=
0.86
nM
-9.065502
MOAD
Ki=0.86nM
null
null
Cc1c(-c2c(-c3ccc(F)o3)sc3ncnc(O[C@H](Cc4ccccc4OCc4ccnn4C)C(=O)[O-])c23)ccc(OCC[NH+]2CCN(C)CC2)c1Cl
761.276
3.98082
132.24
14
53
1
12
0.174046
6ybk
2.0
2,020
OK2
A
403
ki
=
5
nM
-8.30103
MOAD
Ki=5.0nM
null
null
Cc1c(-c2c(-c3ccc(F)cc3)sc3ncnc(O[C@H](Cc4ccccc4OCc4cnccn4)C(=O)[O-])c23)ccc(OCC[NH+]2CCN(C)CC2)c1Cl
769.299
4.44432
127.06
14
54
1
11
0.170051
6ybl
2.1
2,020
OK5
A
402
ki
=
0.029
nM
-10.537602
MOAD
Ki=0.029nM
null
null
COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(-c4ccc(F)cc4)c(-c4ccc(OCC[NH+]5CCN(C)CC5)c(Cl)c4C)c23)C(=O)[O-])n1
875.423
6.11992
136.29
16
62
1
12
0.120389
6yd9
1.6
2,020
ON2
A
301
ic50
=
110
nM
-6.958607
MOAD
ic50=110.0nM
P0AES6
DNA gyrase subunit B
Cc1[nH]c(C(=O)Nc2nc3ccc(NC(=O)CC[NH3+])cc3s2)c(Cl)c1Cl
413.31
3.06242
114.52
5
26
4
4
0.515409
6ydx
3.2
2,020
ONN
A
1101
ki
=
3.3
nM
-8.481486
BindingDB
Ki=3.3nM
Q9UIQ6
Leucyl-cystinyl aminopeptidase
[NH3+][C@H]1CCSSC[C@@H](C(=O)NCc2ccccc2CC(=O)[O-])NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O
560.698
-0.7012
175.3
7
38
5
8
0.276272
6ydx
3.2
2,020
ONN
B
1101
ki
=
3.3
nM
-8.481486
BindingDB
Ki=3.3nM
Q9UIQ6
Leucyl-cystinyl aminopeptidase
[NH3+][C@H]1CCSSC[C@@H](C(=O)NCc2ccccc2CC(=O)[O-])NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O
560.698
-0.7012
175.3
7
38
5
8
0.276272
6ydz
2.9
2,021
4BW
A
401
kd
=
1,040
nM
-5.982967
BindingDB
EC50=120nM,Kd=1040nM
Q86WV6
Stimulator of interferon protein
Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[P@@](=O)([O-])O[C@H]4[C@@H](O)[C@H](n5cnc6c(N)ncnc65)O[C@@H]4CO[P@](=O)([O-])O[C@H]3[C@H]2O)c(=O)[nH]1
672.401
-3.6055
335.31
2
45
5
22
0.128335
6yei
2.02
2,020
NAD
A
501
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yei
2.02
2,020
NAD
B
501
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yei
2.02
2,020
NAD
C
501
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yei
2.02
2,020
NAD
D
502
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yei
2.02
2,020
NAD
E
502
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yei
2.02
2,020
NAD
F
501
kd
=
72
uM
-4.142668
MOAD
Kd=72.0uM
Q43314
Glutamate dehydrogenase 1
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6yem
2.5
2,020
OOH
A
205
ic50
=
0.29
uM
-6.537602
MOAD
ic50=0.29uM
C3W5X6
Polymerase acidic protein,Polymerase acidic protein
CCCCC(=O)C1=C([O-])C(=O)c2c(O)c(O)cc(O)c2C1=O
305.262
0.5561
134.96
4
22
3
7
0.419802
6yh4
1.3
2,021
V13
A
302
kd
=
17
nM
-7.769551
BindingDB
Kd=17nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(F)c1F
337.272
-0.3436
114.53
4
20
2
5
0.575973
6yh5
1.2
2,021
E1F
A
302
kd
=
11
nM
-7.958607
BindingDB
Kd=11nM,kon=390000M-1-s-1,koff=0.0042s-1
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(C(=O)CSc2ncccn2)cc1Cl
343.817
1.7524
103.01
5
21
1
6
0.503708
6yha
1.25
2,021
3TV
A
306
kd
=
0.91
nM
-9.040959
BindingDB
Kd=0.91nM
P00918
Carbonic anhydrase 2
CCCSc1c(F)c(F)c(S(N)(=O)=O)c(F)c1F
303.302
2.3925
60.16
4
18
1
3
0.527656
6yha
1.25
2,021
3TV
A
305
kd
=
0.91
nM
-9.040959
BindingDB
Kd=0.91nM
P00918
Carbonic anhydrase 2
CCCSc1c(F)c(F)c(S(N)(=O)=O)c(F)c1F
303.302
2.3925
60.16
4
18
1
3
0.527656
6yhb
1.65
2,021
V50
A
302
kd
=
10
nM
-8
BindingDB
Kd=10.0nM
P00918
Carbonic anhydrase 2
Cc1cc(C)nc(Sc2c(F)c(F)c(S(N)(=O)=O)c(F)c2F)n1
367.349
2.44844
85.94
3
23
1
5
0.511627
6yhc
1.28
2,021
WWO
A
303
kd
=
6.1
nM
-8.21467
BindingDB
Kd=6.1nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(NCc2ccccc2)c1F
424.422
1.1294
126.56
7
27
3
6
0.572199
6yid
2.7
2,020
EDJ
A
301
ic50
=
711
nM
-6.14813
BindingDB
IC50=711nM
Q8IYT8
Serine/threonine-protein kinase ULK2
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
489.326
4.1604
103.83
8
31
2
8
0.48645
6yid
2.7
2,020
EDJ
B
301
ic50
=
711
nM
-6.14813
BindingDB
IC50=711nM
Q8IYT8
Serine/threonine-protein kinase ULK2
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
489.326
4.1604
103.83
8
31
2
8
0.48645
6yid
2.7
2,020
EDJ
C
301
ic50
=
711
nM
-6.14813
BindingDB
IC50=711nM
Q8IYT8,Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
489.326
4.1604
103.83
8
31
2
8
0.48645
6yid
2.7
2,020
EDJ
D
301
ic50
=
711
nM
-6.14813
BindingDB
IC50=711nM
Q8IYT8
Serine/threonine-protein kinase ULK2
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
489.326
4.1604
103.83
8
31
2
8
0.48645
6yjc
1.74100939272
2,020
OSZ
A
401
ic50
=
81.3
nM
-7.089909
MOAD
ic50=81.3nM
P47811
Mitogen-activated protein kinase 14
Nc1c(C(=O)NCc2ccc(C(=O)N[C@@H](CCC3CCCCC3)C(=O)N3CC[NH2+]CC3)cc2)cnn1-c1ccccc1
572.734
2.249
138.96
10
42
4
6
0.295222
6yjm
2.25
2,021
OU5
A
505
ic50
=
20
nM
-7.69897
BindingDB
IC50=20.0nM
Q9UNA0,Q9UNA0
A disintegrin and metalloproteinase with thrombospondin motifs 5,A disintegrin and metalloproteinase with thrombospondin motifs 5
C[C@H]1CN(C(=O)CC[C@@]2(C3CC3)NC(=O)NC2=O)CCN1c1cc(F)cc(F)c1
406.433
1.7703
81.75
5
29
2
4
0.730652
6yjm
2.25
2,021
OU5
B
505
ic50
=
20
nM
-7.69897
BindingDB
IC50=20.0nM
Q9UNA0,Q9UNA0
A disintegrin and metalloproteinase with thrombospondin motifs 5,A disintegrin and metalloproteinase with thrombospondin motifs 5
C[C@H]1CN(C(=O)CC[C@@]2(C3CC3)NC(=O)NC2=O)CCN1c1cc(F)cc(F)c1
406.433
1.7703
81.75
5
29
2
4
0.730652
6yk2
1.612
2,020
CGW
A
309
ki
=
0.762
uM
-6.118045
MOAD
Ki=0.762uM
P19491
Glutamate receptor 2,Glutamate receptor 2
[NH3+][C@@H](Cn1c2c(c(=O)[nH]c1=O)CSC2)C(=O)[O-]
257.271
-3.3562
122.63
3
17
2
6
0.585272
6yk3
1.2
2,020
PVQ
A
309
ki
=
17.5
uM
-4.756962
MOAD
Ki=17.5uM
P19491
Glutamate receptor 2,Glutamate receptor 2
[NH3+][C@@H](Cn1c2c(c(=O)[nH]c1=O)C[NH2+]C2)C(=O)[O-]
241.227
-5.526
139.24
3
17
3
5
0.485218
6yk4
0.999
2,020
CG8
A
310
ki
=
7.89
uM
-5.102923
MOAD
Ki=7.89uM
P19491
Glutamate receptor 2,Glutamate receptor 2
C[N@H+]1Cc2c(n(C[C@H]([NH3+])C(=O)[O-])c(=O)[nH]c2=O)C1
255.254
-5.5747
127.07
3
18
3
5
0.497345
6yk5
1.15
2,020
PVK
A
312
ki
=
4.73
uM
-5.325139
MOAD
Ki=4.73uM
P19491
Glutamate receptor 2
[NH3+][C@@H](Cn1c2c(c(=O)[nH]c1=O)COC2)C(=O)[O-]
241.203
-4.0728
131.86
3
17
2
6
0.555122
6yk6
1.469
2,020
OUB
A
311
ki
=
135
uM
-3.869666
MOAD
Ki=135.0uM
P19491
Glutamate receptor 2,Glutamate receptor 2
[NH3+][C@@H](Cn1c(=O)[nH]c(=O)c2cocc21)C(=O)[O-]
239.187
-3.3568
135.77
3
17
2
6
0.576139
6ykk
2.236
2,020
OVK
A
1101
ki
=
30.94
nM
-7.50948
MOAD
Ki=30.94nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](CCn2nnc(-c3ccccc3)n2)[C@H](O)[C@@H]1O
499.57
-1.7464
193.4
11
34
4
11
0.275436
6ykl
2.27
2,020
OVH
A
1101
ki
=
2.48
nM
-8.605548
MOAD
Ki=2.48nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1OC[C@@H](CCCn2cc(-c3ccccc3)nn2)[C@H](O)[C@@H]1O
526.636
-0.5037
180.51
12
36
4
10
0.283298
6yko
2.21
2,020
OW5
A
1101
ki
=
5.51
nM
-8.258848
MOAD
Ki=5.51nM
Q5FAJ3
Leucine--tRNA ligase
CCCCCc1ccc(-c2cn(CCC[C@@H]3CO[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CC(C)C)[C@@H](O)[C@H]3O)nn2)cc1
596.771
1.229
180.51
16
41
4
10
0.207277
6ykq
1.94
2,020
OVW
A
1101
ki
=
52.36
nM
-7.281
MOAD
Ki=52.36nM
Q5FAJ3
Leucine--tRNA ligase
CCCCCCCCc1cn(CCC[C@@H]2CO[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CC(C)C)[C@@H](O)[C@H]2O)nn1
562.754
0.7323
180.51
18
38
4
10
0.187563
6yks
1.97
2,020
OVT
A
1201
ki
=
108.35
nM
-6.965171
MOAD
Ki=108.35nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1OC[C@@H](CCCn2cc(CCc3ccccc3)nn2)[C@H](O)[C@@H]1O
554.69
-0.3855
180.51
14
38
4
10
0.241867
6ykt
2.32
2,020
OVN
A
901
ki
=
387.66
nM
-6.411549
MOAD
Ki=387.66nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1OC[C@@H](CCCn2cc(CCCCO)nn2)[C@H](O)[C@@H]1O
522.645
-1.8557
200.74
15
35
5
11
0.162702
6yku
2.14
2,020
OVB
A
1102
ki
=
17.83
nM
-7.748849
MOAD
Ki=17.83nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1OC[C@@H](CCCn2cc(-c3ccc(OC(F)(F)F)cc3)nn2)[C@H](O)[C@@H]1O
610.632
0.3949
189.74
13
41
4
11
0.246953
6ykv
2.43
2,020
OVQ
A
901
ki
=
31.62
nM
-7.500038
MOAD
Ki=31.62nM
Q5FAJ3
Leucine--tRNA ligase
CC(C)C[C@H]([NH3+])C(=O)NS(=O)(=O)OC[C@H]1OC[C@@H](CCCn2cc(-c3cccnc3)nn2)[C@H](O)[C@@H]1O
527.624
-1.1087
193.4
12
36
4
11
0.262894