PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
7jv8
2.46
2,020
VPD
D
604
ic50
=
0.25
nM
-9.60206
MOAD
ic50=0.25nM
P21589
5'-nucleotidase
COC[C@](CO)(OC[C@H]1O[C@@H](n2ncc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O)P(=O)([O-])[O-]
535.878
-1.2813
207.2
10
35
4
14
0.20655
7jvm
2.166
2,020
VKS
A
601
ic50
=
0.011
uM
-7.958607
MOAD
ic50=0.011uM
Q06124
Tyrosine-protein phosphatase non-receptor type 11
C[C@@H]1OCC2(CCN(c3cnc(Sc4ccnc(N)c4Cl)c(N)n3)CC2)[C@@H]1[NH3+]
422.966
1.4564
130.82
3
28
3
8
0.676897
7jvm
2.166
2,020
VKS
B
601
ic50
=
0.011
uM
-7.958607
MOAD
ic50=0.011uM
Q06124
Tyrosine-protein phosphatase non-receptor type 11
C[C@@H]1OCC2(CCN(c3cnc(Sc4ccnc(N)c4Cl)c(N)n3)CC2)[C@@H]1[NH3+]
422.966
1.4564
130.82
3
28
3
8
0.676897
7jvn
1.917
2,020
VKP
A
601
ic50
=
0.029
uM
-7.537602
MOAD
ic50=0.029uM
Q06124
Tyrosine-protein phosphatase non-receptor type 11
CC1([NH3+])CCN(c2cnc(Sc3cccc(Cl)c3Cl)c(N)n2)CC1
385.344
3.1176
82.68
3
24
2
5
0.848455
7jvn
1.917
2,020
VKP
B
601
ic50
=
0.029
uM
-7.537602
MOAD
ic50=0.029uM
Q06124
Tyrosine-protein phosphatase non-receptor type 11
CC1([NH3+])CCN(c2cnc(Sc3cccc(Cl)c3Cl)c(N)n2)CC1
385.344
3.1176
82.68
3
24
2
5
0.848455
7jvp
NMR
2,021
SK9
R
501
ki
=
1.18
nM
-8.928118
BindingDB
Ki=1.18nM,EC50=>10000nM
P21728
D(1A) dopamine receptor
Cc1cccc([C@H]2C[N@@H+](C)CCc3c2cc(O)c(O)c3Cl)c1
318.824
2.26232
44.9
1
22
3
2
0.706304
7jvq
NMR
2,021
OR9
R
501
kd
=
680
nM
-6.167491
BindingDB
Ki=72nM,EC50=521nM,Kd=680nM
P21728
D(1A) dopamine receptor
C[N@@H+]1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
268.336
1.4328
44.9
0
20
3
2
0.632997
7jvu
1.5004765401
2,020
SHH
A
404
kd
=
1,200
nM
-5.920819
BindingDB
IC50=2000nM,Ki=480nM,Kd=1.2e+3nM
Q9BY41,Q9BY41
Histone deacetylase 8,Histone deacetylase 8
O=C(CCCCCCC(=O)Nc1ccccc1)NO
264.325
2.4711
78.43
8
19
3
3
0.38322
7jvu
1.5004765401
2,020
SHH
B
404
kd
=
1,200
nM
-5.920819
BindingDB
IC50=2000nM,Ki=480nM,Kd=1.2e+3nM
Q9BY41,Q9BY41
Histone deacetylase 8,Histone deacetylase 8
O=C(CCCCCCC(=O)Nc1ccccc1)NO
264.325
2.4711
78.43
8
19
3
3
0.38322
7jwe
2.55
2,021
VL1
A
1201
kd
=
24
nM
-7.619789
BindingDB
IC50=6.0nM,Kd=24nM
P48736
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
C[NH+](C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1
616.747
1.6049
129.49
7
45
3
9
0.36268
7jws
1.6
2,020
VLY
A
602
ic50
=
0.13
uM
-6.886057
MOAD
ic50=0.13uM
P00352
Retinal dehydrogenase 1
C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1
362.458
3.9725
52.71
4
26
0
6
0.407086
7jwt
1.8
2,020
VM4
A
602
ic50
=
0.13
uM
-6.886057
MOAD
ic50=0.13uM
P00352
Retinal dehydrogenase 1
C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccc(O)c1
378.457
3.6781
72.94
4
27
1
7
0.433176
7jwu
1.9
2,020
VMA
A
606
ic50
=
0.242
uM
-6.616185
MOAD
ic50=0.242uM
P00352
Retinal dehydrogenase 1
C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccn1
363.446
3.3675
65.6
4
26
0
7
0.410794
7jwv
1.6
2,020
VMJ
A
602
ic50
=
0.6
uM
-6.221849
MOAD
ic50=0.6uM
P00352
Retinal dehydrogenase 1
C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccc(CO)cc1)c1ccccc1
392.484
3.4648
72.94
5
28
1
7
0.415896
7jww
1.6
2,020
VMG
A
602
ic50
=
0.36
uM
-6.443697
MOAD
ic50=0.36uM
P00352
Retinal dehydrogenase 1
C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccc(CCO)cc1)c1ccccc1
406.511
3.5073
72.94
6
29
1
7
0.391862
7jwz
2.65
2,021
V7Y
A
1201
kd
=
0.29
nM
-9.537602
BindingDB
IC50=2000nM,Kd=0.290000nM
P48736
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
528.576
3.2399
125.13
4
40
2
9
0.338614
7jx0
3.15
2,021
VLV
A
1201
ki
=
88
nM
-7.055517
BindingDB
Ki=88nM
P48736
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
CC(=O)c1ccc(-c2sc(NC(=O)NCCC(=O)NC(C)(C)C)nc2C)cc1
402.52
3.74742
100.19
6
28
3
5
0.640776
7jxk
3.1
2,021
JBJ
A
1102
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccc(-c3ccc(N4CC[NH2+]CC4)cc3)cc2C1=O
544.632
3.374
102.38
6
39
3
6
0.345579
7jxk
3.1
2,021
JBJ
C
1102
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P00533,P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccc(-c3ccc(N4CC[NH2+]CC4)cc3)cc2C1=O
544.632
3.374
102.38
6
39
3
6
0.345579
7jxk
3.1
2,021
JBJ
D
1103
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccc(-c3ccc(N4CC[NH2+]CC4)cc3)cc2C1=O
544.632
3.374
102.38
6
39
3
6
0.345579
7jxk
3.1
2,021
JBJ
E
1102
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P00533
Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccc(-c3ccc(N4CC[NH2+]CC4)cc3)cc2C1=O
544.632
3.374
102.38
6
39
3
6
0.345579
7jxk
3.1
2,021
JBJ
F
1102
ic50
>=
1,000
nM
-6
BindingDB
IC50=>1000nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccc(-c3ccc(N4CC[NH2+]CC4)cc3)cc2C1=O
544.632
3.374
102.38
6
39
3
6
0.345579
7jxm
2.192
2,021
YY3
B
1101
ki
=
14
nM
-7.853872
BindingDB
IC50=2.0nM,Ki=14nM,EC50=6.0nM
P00533
Epidermal growth factor receptor
C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CC[NH+](C)C
500.627
3.0927
88.75
10
37
3
7
0.290194
7jxm
2.192
2,021
9LL
B
1102
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
P00533
Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccccc2C1=O
383.404
3.3236
82.53
4
27
2
5
0.724063
7jxm
2.192
2,021
9LL
D
1103
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
P00533
Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccccc2C1=O
383.404
3.3236
82.53
4
27
2
5
0.724063
7k0u
2.52
2,021
R78
A
1701
kd
=
170
nM
-6.769551
BindingDB
IC50=160nM,Kd=170nM
P21675
Transcription initiation factor TFIID subunit 1
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)N[C@H]4CC[N@H+](C)CC4)cc3OC)nc2N1C1CCCC1
522.674
2.1397
104.13
7
38
3
7
0.511924
7k0u
2.52
2,021
R78
B
1702
kd
=
170
nM
-6.769551
BindingDB
IC50=160nM,Kd=170nM
P21675
Transcription initiation factor TFIID subunit 1
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)N[C@H]4CC[N@@H+](C)CC4)cc3OC)nc2N1C1CCCC1
522.674
2.1397
104.13
7
38
3
7
0.511924
7k1p
2.45
2,021
BMF
A
1701
kd
=
17
nM
-7.769551
BindingDB
Kd=17nM
P21675
Transcription initiation factor TFIID subunit 1
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12
404.452
2.34804
127.58
5
28
2
8
0.667879
7k2u
1.73
2,020
VU7
A
403
ic50
=
0.12
nM
-9.920819
MOAD
ic50=0.12nM
Q02127
Dihydroorotate dehydrogenase (quinone), mitochondrial
CONC(=O)c1c(C)c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc12
404.416
5.44662
51.22
4
30
1
3
0.460556
7k4b
NMR
2,020
VUG
A
701
ic50
=
320
nM
-6.49485
BindingDB
IC50=320nM
Q9H1D0,Q9H1D0
Transient receptor potential cation channel subfamily V member 6,Transient receptor potential cation channel subfamily V member 6
Cc1cccc([C@H]2CC[C@@H]([NH+]3CCN(c4cccnc4)CC3)CC2)c1
336.503
2.82132
20.57
3
25
1
2
0.930211
7k4b
NMR
2,020
VUG
A
713
ic50
=
320
nM
-6.49485
BindingDB
IC50=320nM
Q9H1D0,Q9H1D0
Transient receptor potential cation channel subfamily V member 6,Transient receptor potential cation channel subfamily V member 6
Cc1cccc([C@H]2CC[C@@H]([NH+]3CCN(c4cccnc4)CC3)CC2)c1
336.503
2.82132
20.57
3
25
1
2
0.930211
7k4b
NMR
2,020
VUG
B
704
ic50
=
320
nM
-6.49485
BindingDB
IC50=320nM
Q9H1D0,Q9H1D0
Transient receptor potential cation channel subfamily V member 6,Transient receptor potential cation channel subfamily V member 6
Cc1cccc([C@H]2CC[C@@H]([NH+]3CCN(c4cccnc4)CC3)CC2)c1
336.503
2.82132
20.57
3
25
1
2
0.930211
7k4q
1.28
2,020
6NT
A
401
kd
=
372.5
uM
-3.428874
MOAD
Kd=372.5uM
P23360
Endo-1,4-beta-xylanase
O=[N+]([O-])c1ccc2nn[nH]c2c1
164.124
0.8661
84.71
1
12
1
4
0.500052
7k4q
1.28
2,020
6NT
B
401
kd
=
372.5
uM
-3.428874
MOAD
Kd=372.5uM
P23360
Endo-1,4-beta-xylanase
O=[N+]([O-])c1ccc2nn[nH]c2c1
164.124
0.8661
84.71
1
12
1
4
0.500052
7k4x
1.6
2,020
6NT
A
401
kd
=
13.04
uM
-4.884722
MOAD
Kd=13.04uM
P23360
Endo-1,4-beta-xylanase
O=[N+]([O-])c1ccc2nn[nH]c2c1
164.124
0.8661
84.71
1
12
1
4
0.500052
7k4x
1.6
2,020
6NT
B
401
kd
=
13.04
uM
-4.884722
MOAD
Kd=13.04uM
P23360
Endo-1,4-beta-xylanase
O=[N+]([O-])c1ccc2nn[nH]c2c1
164.124
0.8661
84.71
1
12
1
4
0.500052
7k6h
1.5
2,021
4WG
A
201
kd
=
1,600
nM
-5.79588
BindingDB
Kd=1600nM
O60885
Bromodomain-containing protein 4
CCOc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C
474.565
3.9379
94.06
5
35
2
8
0.57445
7k6i
1.406
2,020
VYV
A
302
ki
=
444.5
nM
-6.352128
MOAD
Ki=444.5nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccccc2)cc1
398.466
0.8974
147.46
7
26
4
5
0.546821
7k6j
1.755
2,020
VYY
A
302
ki
=
50.8
nM
-7.294136
MOAD
Ki=50.8nM
P00918
Carbonic anhydrase 2
Cc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(S(N)(=O)=O)cc2)cc1
412.493
1.20582
147.46
7
27
4
5
0.539401
7k6k
1.306
2,020
VZ1
A
303
ki
=
474.5
nM
-6.323764
MOAD
Ki=474.5nM
P00918
Carbonic anhydrase 2
Cc1cc(C)cc(NC(=O)NCCS(=O)(=O)Nc2ccc(S(N)(=O)=O)cc2)c1
426.52
1.51424
147.46
7
28
4
5
0.529707
7k6l
1.655
2,020
VZD
A
302
ki
=
458.3
nM
-6.33885
MOAD
Ki=458.3nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(F)cc2)cc1
416.456
1.0365
147.46
7
27
4
5
0.532235
7k6n
2.77
2,021
VY4
A
9001
ki
<=
0.018
nM
-10.744727
BindingDB
Ki=<0.018nM
P42336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
CC(C)(C)OC(=O)N1CC[C@](C)(N2CCc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc32)C1
482.589
2.1144
122.83
3
35
1
10
0.69566
7k6o
2.738
2,021
VY1
A
9001
ki
=
0.124
nM
-9.906578
BindingDB
Ki=0.124nM
P42336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
CNS(=O)(=O)N1CC[C@H](N2CCc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc32)C1
461.552
-0.7466
142.7
5
32
2
10
0.583911
7k71
2.9
2,021
VYP
A
9001
ic50
=
14
nM
-7.853872
BindingDB
EC50=130nM,IC50=14nM
P42336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Nc1ncc(-c2ccnc(N3CCOCC3)n2)cn1
258.285
0.3524
90.05
2
19
1
7
0.830817
7kbg
1.26
2,020
WBA
A
411
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
Q92769
Histone deacetylase 2
O=C(N[C@@H](CCCCNC(=O)c1c(O)cccc1F)c1ncc(-c2ccc3ccccc3c2)[nH]1)c1cncs1
543.624
5.6025
120
10
39
4
6
0.17094
7kbg
1.26
2,020
WBA
B
409
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
Q92769
Histone deacetylase 2
O=C(N[C@@H](CCCCNC(=O)c1c(O)cccc1F)c1ncc(-c2ccc3ccccc3c2)[nH]1)c1cncs1
543.624
5.6025
120
10
39
4
6
0.17094
7kbg
1.26
2,020
WBA
C
412
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
Q92769,Q92769
Histone deacetylase 2,Histone deacetylase 2
O=C(N[C@@H](CCCCNC(=O)c1c(O)cccc1F)c1ncc(-c2ccc3ccccc3c2)[nH]1)c1cncs1
543.624
5.6025
120
10
39
4
6
0.17094
7kbs
1.834
2,020
RAL
A
601
ki
=
0.37
nM
-9.431798
BindingDB
IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
P03372
Estrogen receptor
O=C(c1ccc(OCC[NH+]2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12
474.602
4.6581
71.2
7
34
3
5
0.340925
7kbs
1.834
2,020
RAL
B
601
ki
=
0.37
nM
-9.431798
BindingDB
IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
P03372
Estrogen receptor
O=C(c1ccc(OCC[NH+]2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12
474.602
4.6581
71.2
7
34
3
5
0.340925
7kc5
1.86
2,021
BJZ
A
402
ic50
=
2.5
nM
-8.60206
BindingDB
IC50=2.5nM
P20701
Integrin alpha-L
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)[O-])cn1)C[C@H]2c1ccc(C#N)cc1
535.367
3.06478
120.67
4
37
0
7
0.471167
7kc5
1.86
2,021
BJZ
C
402
ic50
=
2.5
nM
-8.60206
BindingDB
IC50=2.5nM
P20701
Integrin alpha-L
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)[O-])cn1)C[C@H]2c1ccc(C#N)cc1
535.367
3.06478
120.67
4
37
0
7
0.471167
7kc6
1.85
2,021
803
A
401
kd
=
12,900
nM
-4.88941
BindingDB
Kd=12900nM,IC50=2400nM
P20701
Integrin alpha-L
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
404.547
4.1955
72.83
6
29
1
5
0.671999
7kdo
1.6
2,020
H73
A
201
ic50
=
0.38
uM
-6.420216
MOAD
ic50=0.38uM
P26281
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CC1(C)Nc2nc(N)[nH]c(=O)c2N=C1C(=O)NCC[N@H+]1CC[C@@H](SC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)C[C@@H]1C(=O)[O-]
672.729
-4.3148
289.14
9
47
8
17
0.106652
7kdr
1.488
2,020
J1L
A
201
kd
=
0.047
uM
-7.327902
MOAD
Kd=0.047uM
P26281
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CC1(C)Nc2nc(N)[nH]c(=O)c2N=C1C(=O)NCC[N@H+]1CC[C@@H](S(=O)(=O)C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)C[C@@H]1C(=O)[O-]
704.727
-5.6332
323.28
9
49
8
18
0.102888
7khg
2.15
2,021
P31
A
1001
ic50
=
27
nM
-7.568636
BindingDB
IC50=27nM
P10721
Mast/stem cell growth factor receptor Kit
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
417.822
5.228
66.49
5
29
2
4
0.466458
7khv
2.3
2,020
X1A
A
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7khv
2.3
2,020
X1A
B
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7khv
2.3
2,020
X1A
C
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7khv
2.3
2,020
X1A
D
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7khv
2.3
2,020
X1A
E
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7khv
2.3
2,020
X1A
F
701
ic50
=
3,300
nM
-5.481486
MOAD
ic50=3300.0nM
Q0TR53,Q0TR53
O-GlcNAcase NagJ,O-GlcNAcase NagJ
CC(=O)Nc1ncc(C[N@H+]2C[C@@]3(CCN(c4cc(C)nc5ncnn45)C3)C2)s1
399.504
0.14282
92.75
4
28
2
8
0.648554
7kjs
2.187
2,021
WG1
A
301
ki
=
0.12
nM
-9.920819
BindingDB
Ki=0.120nM
P24941
Cyclin-dependent kinase 2
C[C@@]1(O)CCC[C@H]1n1c(=O)c(C(F)F)cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc21
471.53
2.041
117.42
5
32
2
8
0.685276
7kk3
2.06
2,021
2YQ
A
9001
ki
=
1.2
nM
-8.920819
BindingDB
Ki=1.2nM,IC50=0.570000nM,EC50=2.5nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1
380.358
2.6285
88.49
2
28
2
6
0.558167
7kk3
2.06
2,021
2YQ
B
9001
ki
=
1.2
nM
-8.920819
BindingDB
Ki=1.2nM,IC50=0.570000nM,EC50=2.5nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1
380.358
2.6285
88.49
2
28
2
6
0.558167
7kk3
2.06
2,021
2YQ
C
9001
ki
=
1.2
nM
-8.920819
BindingDB
Ki=1.2nM,IC50=0.570000nM,EC50=2.5nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1
380.358
2.6285
88.49
2
28
2
6
0.558167
7kk3
2.06
2,021
2YQ
D
9001
ki
=
1.2
nM
-8.920819
BindingDB
Ki=1.2nM,IC50=0.570000nM,EC50=2.5nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1
380.358
2.6285
88.49
2
28
2
6
0.558167
7kk4
1.96
2,021
09L
A
9001
kd
=
0.24
nM
-9.619789
BindingDB
IC50=5.0nM,EC50=3.6nM,Kd=0.240000nM
P09874
Poly [ADP-ribose] polymerase 1
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
434.471
2.3474
86.37
4
32
1
4
0.683092
7kk4
1.96
2,021
09L
B
9001
kd
=
0.24
nM
-9.619789
BindingDB
IC50=5.0nM,EC50=3.6nM,Kd=0.240000nM
P09874
Poly [ADP-ribose] polymerase 1
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
434.471
2.3474
86.37
4
32
1
4
0.683092
7kk5
1.7
2,021
3JD
A
9001
ki
=
3.2
nM
-8.49485
BindingDB
IC50=132nM,Ki=3.2nM,EC50=31000nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCC[NH2+]C4)cc3)nc12
321.404
1.5652
77.52
3
24
2
3
0.767884
7kk5
1.7
2,021
3JD
B
9001
ki
=
3.2
nM
-8.49485
BindingDB
IC50=132nM,Ki=3.2nM,EC50=31000nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCC[NH2+]C4)cc3)nc12
321.404
1.5652
77.52
3
24
2
3
0.767884
7kk5
1.7
2,021
3JD
C
9001
ki
=
3.2
nM
-8.49485
BindingDB
IC50=132nM,Ki=3.2nM,EC50=31000nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCC[NH2+]C4)cc3)nc12
321.404
1.5652
77.52
3
24
2
3
0.767884
7kk5
1.7
2,021
3JD
D
1103
ki
=
3.2
nM
-8.49485
BindingDB
IC50=132nM,Ki=3.2nM,EC50=31000nM
P09874,P09874
Poly [ADP-ribose] polymerase 1,Poly [ADP-ribose] polymerase 1
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCC[NH2+]C4)cc3)nc12
321.404
1.5652
77.52
3
24
2
3
0.767884
7kk6
2.06
2,021
78P
A
9001
kd
=
1.7
nM
-8.769551
BindingDB
IC50=1.5nM,Ki=5nM,EC50=5.9nM,Kd=1.7nM
P09874
Poly [ADP-ribose] polymerase 1
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kk6
2.06
2,021
78P
B
9001
kd
=
1.7
nM
-8.769551
BindingDB
IC50=1.5nM,Ki=5nM,EC50=5.9nM,Kd=1.7nM
P09874
Poly [ADP-ribose] polymerase 1
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kko
1.56
2,021
09L
A
1402
ic50
=
1,230
nM
-5.910095
BindingDB
IC50=1230nM
O95271
Poly [ADP-ribose] polymerase
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
434.471
2.3474
86.37
4
32
1
4
0.683092
7kko
1.56
2,021
09L
B
1402
ic50
=
1,230
nM
-5.910095
BindingDB
IC50=1230nM
O95271,O95271
Poly [ADP-ribose] polymerase,Poly [ADP-ribose] polymerase
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
434.471
2.3474
86.37
4
32
1
4
0.683092
7kko
1.56
2,021
09L
C
1402
ic50
=
1,230
nM
-5.910095
BindingDB
IC50=1230nM
O95271,O95271
Poly [ADP-ribose] polymerase,Poly [ADP-ribose] polymerase
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
434.471
2.3474
86.37
4
32
1
4
0.683092
7kkq
1.59
2,021
78P
A
9001
ic50
=
10,715
nM
-4.970008
BindingDB
IC50=10715nM
O95271
Poly [ADP-ribose] polymerase
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kkq
1.59
2,021
78P
B
9001
ic50
=
10,715
nM
-4.970008
BindingDB
IC50=10715nM
O95271
Poly [ADP-ribose] polymerase
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kkq
1.59
2,021
78P
C
9001
ic50
=
10,715
nM
-4.970008
BindingDB
IC50=10715nM
O95271
Poly [ADP-ribose] polymerase
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kkq
1.59
2,021
78P
D
9001
ic50
=
10,715
nM
-4.970008
BindingDB
IC50=10715nM
O95271
Poly [ADP-ribose] polymerase
C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCC[NH2+]1
245.306
0.2342
88.38
2
18
3
2
0.707032
7kqj
2.645
2,021
Z8G
A
4000
ic50
=
6
nM
-8.221849
BindingDB
IC50=6.00nM
P51449
Nuclear receptor ROR-gamma
CC(C)(O)C(=O)N[C@@H]1CC[C@@]2(S(=O)(=O)c3ccc(F)cc3)c3ccc(C(F)(C(F)(F)F)C(F)(F)F)cc3CC[C@@H]12
599.54
5.3962
83.47
5
40
2
4
0.356609
7krj
NMR
2,022
DEX
D
801
kd
=
19
nM
-7.721246
BindingDB
EC50=2.5nM,Ki=1.2nM,IC50=5nM,Kd=19nM
P04150
Glucocorticoid receptor
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
392.467
1.8957
94.83
2
28
3
5
0.667213
7kx6
2.5
2,021
X7Y
A
701
kd
=
1.2
nM
-8.920819
BindingDB
Kd=1.2nM,IC50=11nM
O15075
Serine/threonine-protein kinase DCLK1
COc1cc(N2CC[NH+](C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C
460.562
1.9214
78.27
4
34
2
7
0.616018
7kx6
2.5
2,021
X7Y
B
701
kd
=
1.2
nM
-8.920819
BindingDB
Kd=1.2nM,IC50=11nM
O15075
Serine/threonine-protein kinase DCLK1
COc1cc(N2CC[NH+](C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C
460.562
1.9214
78.27
4
34
2
7
0.616018
7kx8
3.1
2,021
X8J
A
701
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
O15075
Serine/threonine-protein kinase DCLK1
CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(N4CC[NH+](C)CC4)cc3OC)ncc21
474.589
2.3115
78.27
5
35
2
7
0.587662
7kx8
3.1
2,021
X8J
B
701
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
O15075
Serine/threonine-protein kinase DCLK1
CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(N4CC[NH+](C)CC4)cc3OC)ncc21
474.589
2.3115
78.27
5
35
2
7
0.587662
7kxt
2.15
2,021
XB7
A
501
ki
=
23,010
nM
-4.638083
BindingDB
Ki=23010nM,IC50=93800nM
O75530,O75530
Polycomb protein EED,Polycomb protein EED
COc1ccc(CC[N@H+]2CC[C@H](Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1
459.589
3.9342
43.52
8
34
2
4
0.419645
7kxt
2.15
2,021
XB7
B
501
ki
=
23,010
nM
-4.638083
BindingDB
Ki=23010nM,IC50=93800nM
O75530,O75530
Polycomb protein EED,Polycomb protein EED
COc1ccc(CC[N@H+]2CC[C@H](Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1
459.589
3.9342
43.52
8
34
2
4
0.419645
7kxw
3.002
2,021
XBD
A
701
ic50
=
17
nM
-7.769551
BindingDB
IC50=17nM
O15075
Serine/threonine-protein kinase DCLK1
COc1cc(N2CC[NH+](C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F
528.559
2.8539
78.27
5
38
2
7
0.527555
7kxw
3.002
2,021
XBD
B
701
ic50
=
17
nM
-7.769551
BindingDB
IC50=17nM
O15075
Serine/threonine-protein kinase DCLK1
COc1cc(N2CC[NH+](C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F
528.559
2.8539
78.27
5
38
2
7
0.527555
7l0d
2.39
2,021
0EN
A
401
ic50
=
3,140
nM
-5.50307
BindingDB
IC50=3140nM
P0DTD1
3C-like proteinase
CC(C)(C)NC(=O)[C@@H](c1cccnc1)N(C(=O)c1ccco1)c1ccc(C(C)(C)C)cc1
433.552
5.2749
75.44
5
32
1
4
0.594325
7l11
1.8
2,021
XF1
A
400
ic50
=
140
nM
-6.853872
BindingDB
IC50=140nM,EC50=1510nM
P0DTD1,P0DTD1
3C-like proteinase,3C-like proteinase
CCCOc1cc(Cl)cc(-c2cc(-c3ccccc3C#N)cn(-c3cccnc3)c2=O)c1
441.918
5.88038
67.91
6
32
0
5
0.374359
7l11
1.8
2,021
XF1
B
400
ic50
=
140
nM
-6.853872
BindingDB
IC50=140nM,EC50=1510nM
P0DTD1,P0DTD1
3C-like proteinase,3C-like proteinase
CCCOc1cc(Cl)cc(-c2cc(-c3ccccc3C#N)cn(-c3cccnc3)c2=O)c1
441.918
5.88038
67.91
6
32
0
5
0.374359
7l14
1.8
2,021
XFD
A
400
ic50
=
170
nM
-6.769551
BindingDB
IC50=170nM,EC50=1760nM
P0DTD1,P0DTD1
3C-like proteinase,3C-like proteinase
N#Cc1ccccc1-c1cc(-c2cc(Cl)cc(OCC3CC3)c2)c(=O)n(-c2cccnc2)c1
453.929
5.88038
67.91
6
33
0
5
0.365276
7l14
1.8
2,021
XFD
B
400
ic50
=
170
nM
-6.769551
BindingDB
IC50=170nM,EC50=1760nM
P0DTD1,P0DTD1
3C-like proteinase,3C-like proteinase
N#Cc1ccccc1-c1cc(-c2cc(Cl)cc(OCC3CC3)c2)c(=O)n(-c2cccnc2)c1
453.929
5.88038
67.91
6
33
0
5
0.365276
7l28
2.2
2,021
XKG
A
1101
ic50
=
0.3
nM
-9.522879
BindingDB
IC50=0.3nM
Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(C)c(=O)n1CC2
405.498
3.58476
57.75
3
30
0
6
0.669221
7l28
2.2
2,021
XKG
B
1101
ic50
=
0.3
nM
-9.522879
BindingDB
IC50=0.3nM
Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(C)c(=O)n1CC2
405.498
3.58476
57.75
3
30
0
6
0.669221
7l28
2.2
2,021
XKG
C
1101
ic50
=
0.3
nM
-9.522879
BindingDB
IC50=0.3nM
Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(C)c(=O)n1CC2
405.498
3.58476
57.75
3
30
0
6
0.669221
7l28
2.2
2,021
XKG
D
1101
ic50
=
0.3
nM
-9.522879
BindingDB
IC50=0.3nM
Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(C)c(=O)n1CC2
405.498
3.58476
57.75
3
30
0
6
0.669221