Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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G4T4R7 | AGASK_MEDGN | MAIIYNPNKKIFTLHTAHTTYQMQVDPLGYLLHLYYGEKTNSSMDYVLTYADRGFSGNPYAAGMDRTYSLDALPQEYPSLGTGDYRNIALNIKNEKGVESADLLFKSYEIRNGKYRLQGLPAVWADEKEAQTLEIVLADENAQVEVHLLYGVLEENDVITRSVRIKNTGTGQITIEKAAAACLDFVQGEFDVLRFYGKHAMERNLERTPLGHGTIAFGSRRGTSSHQYNPAVILAEKGTTETAGSCYGMLFVYSGNFSCEAEKDQFNQTRLLLGLNEELFSYPLASGETFTVPEVILSYSAEGLSALSQQYHNCIRNHVC... | 2.7.-.-; 3.2.1.22 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:21931163}; | melibiose catabolic process [GO:0005995]; protein homotetramerization [GO:0051289]; raffinose catabolic process [GO:0034484]; stachyose metabolic process [GO:0033531] | null | alpha-galactosidase activity [GO:0004557]; ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; raffinose alpha-galactosidase activity [GO:0052692] | PF16874;PF16875;PF02065;PF00485; | 3.20.20.70;2.70.98.60;2.60.40.1180;3.40.50.300; | Glycosyl hydrolase 36 family; Uridine kinase family | null | null | CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22; Evidence={ECO:0000269|PubMed:21931163}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.37 mM for p-nitrophenyl-alpha-D-galactopyranoside (at pH 6.0 and 37 degrees Celsius) {ECO:0000269|PubMed:21931163}; Note=kcat/KM is 1850 s(1) mM(1) for p-nitrophenyl-alpha-D-galactopyranoside. {ECO:0000269|PubMed:21931163}; | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.0. Active between pH 4.0-6.5. {ECO:0000269|PubMed:21931163}; | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269|PubMed:21931163}; | FUNCTION: Bifunctional enzyme with alpha-galactosidase and sucrose kinase activities. Produces sucrose-6-phosphate directly from raffinose. Binds ATP. Phosphorylates sucrose specifically on the C6 position of glucose in the presence of ATP. Hydrolyzes melibiose, raffinose, stachyose and synthetic substrate p-nitropheny... | Mediterraneibacter gnavus (Ruminococcus gnavus) |
G4V4G2 | SDHE_SERS3 | MDIDNKPRIHWACRRGMRELDISIMPFFEHDYDTLSDDDKRNFIRLLQCDDPDLFNWLMNHGEPTDQGLKHMVSLIQTRNKNRGPVAM | null | null | antibiotic biosynthetic process [GO:0017000]; respiratory chain complex II assembly [GO:0034552]; succinate metabolic process [GO:0006105] | cytoplasm [GO:0005737] | null | PF03937; | 1.10.150.250; | SdhE FAD assembly factor family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22474332}. | null | null | PATHWAY: Antibiotic biosynthesis; prodigiosin biosynthesis. {ECO:0000269|PubMed:22474332}. | null | null | FUNCTION: An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins (PubMed:24070374, PubMed:24374335). Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle an... | Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida) |
G4VJD5 | PGM_SCHMA | MAPYRIVFIRHGESVYNEENRFCGWHDADLSGQGITEAKQAGQLLRQNHFTFDIAYTSVLKRAIKTLNFVLDELDLNWIPVTKTWRLNERMYGALQGLNKSETAAKHGEEQVKIWRRAYDIPPPPVDISDPRFPGNEPKYALLDSSCIPRTECLKDTVQRVLPFWFDTISASIKRREQVLIVAHGNSLRALIKYLDNTSDSDIVELNIPTGIPLVYELDANLKPTKHYYLADEATVAAAIARVANQGKKK | 5.4.2.11 | null | canonical glycolysis [GO:0061621]; symbiont-mediated activation of host plasminogen [GO:0044542] | null | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538] | PF00300; | 3.40.50.1240; | Phosphoglycerate mutase family, BPG-dependent PGAM subfamily | null | SUBCELLULAR LOCATION: Tegument {ECO:0000269|PubMed:15952743, ECO:0000269|PubMed:16447162, ECO:0000269|PubMed:21468311, ECO:0000269|PubMed:25910674, ECO:0000269|PubMed:36083036}. Note=Exposed on the tegumental surface (PubMed:21468311, PubMed:25910674, PubMed:36083036). Associated with the tegumental surface membranes (... | CATALYTIC ACTIVITY: Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.11; Evidence={ECO:0000269|PubMed:36083036}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.85 mM for 3-phosphoglycerate in the presence of 2,3-bisphosphoglycerate (at pH 7.8) {ECO:0000269|PubMed:36083036}; | PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. {ECO:0000305|PubMed:36083036}. | null | null | FUNCTION: Catalyzes interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate (2,3-BPG) as the primer of the reaction (PubMed:36083036). Schistosomula have significant surface phosphoglycerate mutase activity also without 2,3-BPG (PubMed:36083036). Binds human plasminogen and enhances its conversion to ... | Schistosoma mansoni (Blood fluke) |
G4WJD4 | COLD_YERPU | MRKIMINFPLASSTWDEKELNAIQRIIDSNMFTMGESVKQYEKDFAEYFGSKYSVMVSSGSTANLLMIAALFFTKKPKFKRGDEVIVPAVSWSTTYFPLQQYGLNVRFVDIDKKTLNIDLDKLKSAITEKTKAILAVNLLGNPNDFDAITKITEGKDIFILEDNCESMGARLNGKQAGTYGLMGTFSSFFSHHIATMEGGCVITDDEELYHILLCIRAHGWTRNLPEFNHITGQKSIDPFEESFKFVLPGYNVRPLEMSGAIGIEQLKKLPSFIEMRRKNATIFKELFSSHPYIDIQQETGESSWFGFALILKESSPITR... | 4.2.1.168 | COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:15610039}; | nucleotide-sugar metabolic process [GO:0009225]; polysaccharide biosynthetic process [GO:0000271] | plasma membrane [GO:0005886] | dTDP-4-amino-4,6-dideoxygalactose transaminase activity [GO:0019180]; glutamate binding [GO:0016595]; hydro-lyase activity [GO:0016836]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] | PF01041; | 3.90.1150.10;3.40.640.10; | DegT/DnrJ/EryC1 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+); Xref=Rhea:RHEA:49488, ChEBI:CHEBI:16810, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:57964, ChEBI:CHEBI:73931; EC=4.2.1.168; Evidence={ECO:0000269|PubMed:15610039}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=8.5 uM for GDP-4-keto-6-deoxy-D-mannose (at pH 7 and 37 degrees Celsius) {ECO:0000269|PubMed:15610039}; KM=1.4 mM for L-glutamate (at pH 7 and 37 degrees Celsius) {ECO:0000269|PubMed:15610039}; Note=kcat is 0.6 sec(-1) (at pH 7 and 37 degrees Celsius). {ECO:0000269... | PATHWAY: Nucleotide-sugar metabolism; GDP-L-colitose biosynthesis. {ECO:0000305|PubMed:15610039}. | null | null | FUNCTION: Involved in the biosynthesis of L-colitose, a 3,6-dideoxyhexose present in the O-antigen region of lipopolysaccharides (LPS), where it serves as an antigenic determinant and is vital for bacterial defense and survival. Catalyzes the removal of the C3'-hydroxyl group from GDP-4-keto-6-deoxy-D-mannose via a com... | Yersinia pseudotuberculosis |
G4YRX5 | PSR1_PHYSP | MRLTYVLLVAVTTLLVSCDATKPSTEATAVSKRLLRFVEAADEEERRIDFSPEKLRKMLGDETYRLKKFGKWDSDGHTFDGLKHYLLLSDSSMVKLRNMYKAWLEQ | null | null | null | extracellular region [GO:0005576]; host cell nucleus [GO:0042025] | null | PF16810; | null | RxLR effector family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25902521}. Host nucleus {ECO:0000269|PubMed:25902521}. Note=The nuclear localization is required for this interaction. {ECO:0000269|PubMed:25902521}. | null | null | null | null | null | FUNCTION: Secreted effector that possesses RNA silencing suppression activity by inhibiting the biogenesis of small RNAs in the host plant to promote enhanced susceptibility of host to the pathogen during infection (PubMed:23377181, PubMed:25902521, PubMed:29029698, PubMed:30963588). Interferes with secondary siRNA pro... | Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) |
G4ZHR2 | XEG1_PHYSP | MKGFFAGVVAAATLAVASAGDYCGQWDWAKSTNYIVYNNLWNKNAAASGSQCTGVDKISGSTIAWHTSYTWTGGAATEVKSYSNAALVFSKKQIKNIKSIPTKMKYSYSHSSGTFVADVSYDLFTSSTASGSNEYEIMIWLAAYGGAGPISSTGKAIATVTIGSNSFKLYKGPNGSTTVFSFVATKTITNFSADLQKFLSYLTKNQGLPSSQYLITLEAGTEPFVGTNAKMTVSSFSAAVN | 3.2.1.151 | null | polysaccharide catabolic process [GO:0000272] | extracellular region [GO:0005576]; host cellular component [GO:0018995] | cellulase activity [GO:0008810]; xyloglucan-specific endo-beta-1,4-glucanase activity [GO:0033946] | PF01670; | 2.60.120.180; | Glycosyl hydrolase 12 (cellulase H) family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26163574, ECO:0000269|PubMed:28082413}. Host {ECO:0000269|PubMed:26163574}. Note=Targeted to the host apoplast in order to trigger cell death. {ECO:0000269|PubMed:26163574}. | CATALYTIC ACTIVITY: Reaction=xyloglucan + H2O = xyloglucan oligosaccharides.; EC=3.2.1.151; Evidence={ECO:0000269|PubMed:26163574}; | null | null | null | null | FUNCTION: Glycoside hydrolase that exhibits xyloglucanase activity (PubMed:26163574). Acts as an important virulence factor during P.sojae infection but also acts as a pathogen-associated molecular pattern (PAMP) in soybean and solanaceous species, where it can trigger defense responses including cell death. XEG1-induc... | Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) |
G4ZHR3 | XLP1_PHYSP | MKSFLQLVVVVAALLSVSTADFCSQWRLSKAGKYVIYNNLWNKNAAASGSQCTGVDKISGSTIAWHTSYTWTGGAATEVKSYSNAALVFSKKQIKNIKSIPTKMKYSYSHSSGTFVADVSYDLFTSSTASGSNEYEIMIWLAAYGGAGPISSTGKAIATVTIGSNSFKLYKGPNGSTTVYQPPGLPLST | null | null | polysaccharide catabolic process [GO:0000272] | extracellular region [GO:0005576] | cellulase activity [GO:0008810] | PF01670; | 2.60.120.180; | Glycosyl hydrolase 12 (cellulase H) family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28082413}. | null | null | null | null | null | FUNCTION: Secreted XEG1-like protein that has lost enzyme activity but binds to host soybean apoplastic glucanase inhibitor protein GIP1 more tightly than does XEG1, thus it outcompetes XEG1 for GIP1 binding and frees functional XEG1 to support P.sojae infection (PubMed:28082413). With XEG1, is required to elevate apop... | Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) |
G4ZJX4 | AVH23_PHYSP | MRLTYFLTVIVVATLHAGGTALATAEAPNHAAIVNVASADNVHSLDTTAEIGGRMLRKVKEDTVSKKDHEERGPGAILERQTAFVKKLFSRQNAIVNRAQGAFQRQNAFVNRDQGAFQRQNAFVKRAIQRQNHFKLSDNA | null | null | null | extracellular region [GO:0005576]; host cell cytoplasm [GO:0030430]; host cell nucleus [GO:0042025] | null | PF16810; | null | RxLR effector family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28318979}. Host nucleus {ECO:0000269|PubMed:28318979}. Host cytoplasm {ECO:0000269|PubMed:28318979}. Note=Location into the host nucleus is required for virulence. {ECO:0000269|PubMed:28318979}. | null | null | null | null | null | FUNCTION: Effector that suppresses plant defense responses during the early stages of pathogen infection. Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195). Acts as a modulator of histone acetyltransferase (HAT) in plants. Avh23 binds to the ADA2 subunit of the HAT complex SAGA and d... | Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) |
G4ZSG0 | AVH52_PHYSP | MRLTSILVLVIAATFHTTGTALTLTKDSKAGIANGDSPASGDFIDANSARLLRRVEKDKVDYEQDEQRSFGALKDAVKKLNPVTAVKKFFKQRAKRKKVIQTARDADNNLAWAMKEVYKAAN | null | null | symbiont-mediated perturbation of host transcription [GO:0052026] | extracellular region [GO:0005576]; host cell nucleus [GO:0042025] | null | PF16810; | null | RxLR effector family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30346270}. Host nucleus {ECO:0000269|PubMed:30346270}. | null | null | null | null | null | FUNCTION: Effector that suppresses plant defense responses during the early stages of pathogen infection (PubMed:21653195, PubMed:26163574, PubMed:30346270). Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:26163574, PubMed:30346270). Interacts with host acetyltransferase TAP1 and causes TAP1... | Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) |
G5AY81 | HYAS2_HETGA | MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSDDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSSKSVCIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYSQEFMGNQCSFGDDRHLTNR... | 2.4.1.212 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; | atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; endocardial cushion to mesenchymal transition [GO:0090500]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of u... | cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] | hyaluronan synthase activity [GO:0050501] | PF03142;PF00535; | null | NodC/HAS family | PTM: Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. {ECO:0000250|UniProtKB:Q92819}.; PTM: O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. {ECO:0000250|UniProtKB:Q92819}.; PTM: Ubiquitination at Lys-190; this ubiquitination is essential for hyaluron... | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000250|UniProtKB:Q92819}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q92819}; Multi-... | CATALYTIC ACTIVITY: Reaction=[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP; Xref=Rhea:RHEA:20465, Rhea:RHEA-COMP:12583, Rhea:RHEA-COMP:12585, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.... | null | PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000250|UniProtKB:Q92819}. | null | null | FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By si... | Heterocephalus glaber (Naked mole rat) |
G5BQH4 | APOC3_HETGA | MQPRVFLAVTLLALLASARALETEDASLLGYMQDYMQGYMEHASKTAQDALTRVQDSQMAQQARGWMSDSLSSLQDYWSSFKGKWSGFGFWDATPEEASPTPAPEGI | null | null | cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; chylomicron remnant clearance [GO:0034382]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol import [... | chylomicron [GO:0042627]; intermediate-density lipoprotein particle [GO:0034363]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] | high-density lipoprotein particle receptor binding [GO:0070653]; lipase inhibitor activity [GO:0055102]; phospholipid binding [GO:0005543] | PF05778; | 6.10.90.10; | Apolipoprotein C3 family | PTM: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-101 with a core 1 ... | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02656}. | null | null | null | null | null | FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and ... | Heterocephalus glaber (Naked mole rat) |
G5BQH5 | APOA1_HETGA | MKAVVLAVAVLFLTGSQARHFWQGDEPQTSWDRMKDFAALYVDAIQESGKDCAAQLDASALGKQLNLNLLANWNTLTSTFNNLREQLGSVTKEFWDNLGEDTVWLRQQMNKDLEEVKQKVQSYLDNFQKKVNEEVERYRDKVQPLGKELHKDAQQKLKELQEKLAPLGQDIRQRAREYVDALRTHLGSYTQGMRQGLAKRLEALKESAPVSEYQVKASKHLKTFSEKAKPALEDLRQGLMPVMESLKASFLSSIDQASKQLSAQ | null | null | adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor sig... | endocytic vesicle [GO:0030139]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] | amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:000... | PF01442; | 1.20.5.20;6.10.140.380;1.20.120.20; | Apolipoprotein A1/A4/E family | PTM: Glycosylated. {ECO:0000250}.; PTM: Palmitoylated. {ECO:0000250}.; PTM: Phosphorylation sites are present in the extracellular medium. {ECO:0000250}. | SUBCELLULAR LOCATION: Secreted. | null | null | null | null | null | FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). {ECO:0000250}. | Heterocephalus glaber (Naked mole rat) |
G5BWH8 | APOA2_HETGA | MKLLAMTVLLVTICSLDGALVRRQAEEPDLQGLFSQYFQTVTSYGKDLLQKTKPQDLQAQVQSYFEKTQEQLVPLVKKAGTELFNMLSNMIELKKTQPATA | null | null | cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodelin... | blood microparticle [GO:0072562]; chylomicron [GO:0042627]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] | apolipoprotein receptor binding [GO:0034190]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; lipas... | PF04711; | 6.10.250.100; | Apolipoprotein A2 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}. | null | null | null | null | null | FUNCTION: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Heterocephalus glaber (Naked mole rat) |
G5CV52 | TPS17_SOLLC | MELCTQTVAADHEVIITRRSGSHHPTLWGDHFLAYADLRGANEGEEKQNEDLKEEVRKMLVMAPSKSLEKLELINTIQCLGLGYHFQSEIDESLSYMYTHYEEYSIGDLHAIALCFRLLRQQGYYVSCDAFKKFTNDQGNFKEELVKDVEGMLSLYEAAQFRVHGEQILDEALNFTIAQLKQILPKLSNSQLAQQITNALKYPIKDGIVRVETRKYISFYQQNQNHNEVLLNFAKLDFNILQTLHKKELSDMTRWWKKMELVNTLPYARDRLVECYFWCLGTYFEPQYSVARKMLTKISFYISIIDDTYDIYGKLDELTL... | 4.2.3.-; 4.2.3.106; 4.2.3.113; 4.2.3.114; 4.2.3.15; 4.2.3.47; 4.2.3.54; 4.2.3.73; 4.2.3.81 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:A0A1C9J6A7}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:A0A1C9J6A7}; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250|UniProtKB:A0A1C9J6A7}; | diterpenoid biosynthetic process [GO:0016102]; response to jasmonic acid [GO:0009753]; terpenoid biosynthetic process [GO:0016114] | null | magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333] | PF01397;PF03936; | 1.10.600.10;1.50.10.130; | Terpene synthase family, Tpsa subfamily | null | null | CATALYTIC ACTIVITY: Reaction=(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate; Xref=Rhea:RHEA:68524, ChEBI:CHEBI:33019, ChEBI:CHEBI:49249, ChEBI:CHEBI:60374; Evidence={ECO:0000269|PubMed:21818683}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68525; Evidence={ECO:0000269|PubMed:21818683}; CATALYTIC ... | null | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. {ECO:0000269|PubMed:21818683}. | null | null | FUNCTION: Sesquiterpene synthase involved in the biosynthesis of volatile compounds (PubMed:21818683). Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into gamma-gurjunene, (E)-beta-farnesene and (+)-valencene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into (E)-alpha-bergamotene and (Z)-gamma-bisabol... | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
G5CV54 | TPS14_SOLLC | MATNLTLETDKEIKNMNQLSMIDTTITRPLANYHSSVWKNYFLSYTPQLTEISSQEKLELEELKEKVRQMLVETSDKSTQKLVLIDTIQRLGVAYHFDNEIKISIQNIFDEFEQNKNEDDNDLYIVALRFRLVRGQRHYMSSDVFKKFTNDDGKFKETLTKDVQGLLNLYEATHLRVHGEQILEEALSFTVTHLKSMSPKLDSSLKAQVSEALIQPIYTNVPRVVAPKYIRIYENIESHDDLLLKFVKLDFHILQKMHQRELSELTRWWKDLDHSNKYPYARDKLVECYFWATGVYFGPQYKRARRMITKLIVIITITDD... | 4.2.3.-; 4.2.3.40; 4.2.3.59 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:A0A1C9J6A7}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:A0A1C9J6A7}; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250|UniProtKB:A0A1C9J6A7}; | diterpenoid biosynthetic process [GO:0016102]; terpenoid biosynthetic process [GO:0016114] | null | magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333] | PF01397;PF03936; | 1.10.600.10;1.50.10.130; | Terpene synthase family, Tpsa subfamily | null | null | CATALYTIC ACTIVITY: Reaction=(2Z,6Z)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate; Xref=Rhea:RHEA:68472, ChEBI:CHEBI:33019, ChEBI:CHEBI:49242, ChEBI:CHEBI:60374; Evidence={ECO:0000269|PubMed:21813655}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68473; Evidence={ECO:0000269|PubMed:21813655}; CATAL... | null | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. {ECO:0000269|PubMed:21818683}. | null | null | FUNCTION: Sesquiterpene synthase involved in the biosynthesis of volatile compounds (PubMed:21818683). Mediates the conversion of (2E,6E)-farnesyl diphosphate ((EE)-FPP) into beta-bisabolene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into alpha-bisabolene, but also smaller amounts of (Z)-gamma-bisabolene, (E)-gamm... | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
G5DAC6 | XTH1_DIOKA | MAFMSFINGFSTLFLVALLASSMMAAKGGNFYQDFDVTWGDHRAKIFNGGQLLSLSLDKTSGSGFRSKKEYLFGRIDMQLKLVAGNSAGTVTAYYLSSQGPTHDEIDFEFLGNLSGDPYIVHTNVFTQGKGNREQQFYLWFDPTRNFHTYSVVWNPRQIIFLIDNTPIRVFKNAESIGVPFPKNQPMRIYSSLWNADDWATRGGLVKTDWTKAPFTAYYRNFNAKTCSGACTESFGDGAWQSQELDAHSRRRLRWVQKNFMIYNYCTDLKRFPEGLPKECQRRSRFL | 2.4.1.207 | null | cell wall biogenesis [GO:0042546]; cell wall organization [GO:0071555]; fruit ripening [GO:0009835]; xyloglucan metabolic process [GO:0010411] | apoplast [GO:0048046] | hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; xyloglucan:xyloglucosyl transferase activity [GO:0016762] | PF00722;PF06955; | 2.60.120.200; | Glycosyl hydrolase 16 family, XTH group 2 subfamily | PTM: Contains at least one intrachain disulfide bond essential for its enzymatic activity. {ECO:0000255|RuleBase:RU361120}. | SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|RuleBase:RU361120, ECO:0000269|PubMed:25849978}. Secreted, extracellular space, apoplast {ECO:0000255|RuleBase:RU361120}. | CATALYTIC ACTIVITY: Reaction=breaks a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan.; EC=2.4.1.207; Evidence={ECO:0000255|RuleBase:RU361120, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is between 5-5.5. Loses activity rapidly when pH is lowered from 5 to 4. {ECO:0000269|PubMed:25849978}; | null | FUNCTION: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH) (PubMed:25849978). Overexpression in Arabidopsis transgenic plants results in elevated tolerance to abiotic stress, such as salt, ABA (abscisic acid) and drought stre... | Diospyros kaki (Kaki persimmon) (Diospyros chinensis) |
G5DAC7 | XTH2_DIOKA | MAMGTHFGGLWLALLCMVSATMGAVPRKPVDVPFGRNYVPTWAFDHIKYFNGGSQIQLSLDKYTGTGFQSKGSYLFGHFSMQIKMVPGDSAGTVTAFYLSSQNSEHDEIDFEFLGNRTGQPYILQTNVFTGGKGDREQRIFLWFDPTKEYHSYSVLWNLFLIIFFVDDVPIRVFKNSKDLGVRFPFDQPMKIYSSLWNADDWATRGGLEKTDWSKAPFVASYRSFHVDGCEASVNAKFCDTQGKRWWDQKEFQDLDSFQYRRLRWVRSKYTIYNYCTDRKRYPVMPPECKRDRDI | 2.4.1.207 | null | cell wall biogenesis [GO:0042546]; cell wall organization [GO:0071555]; fruit ripening [GO:0009835]; xyloglucan metabolic process [GO:0010411] | apoplast [GO:0048046] | hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; xyloglucan:xyloglucosyl transferase activity [GO:0016762] | PF00722;PF06955; | 2.60.120.200; | Glycosyl hydrolase 16 family, XTH group 1 subfamily | PTM: Contains at least one intrachain disulfide bond essential for its enzymatic activity. {ECO:0000255|RuleBase:RU361120}. | SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|RuleBase:RU361120, ECO:0000269|PubMed:25849978}. Secreted, extracellular space, apoplast {ECO:0000255|RuleBase:RU361120}. | CATALYTIC ACTIVITY: Reaction=breaks a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan.; EC=2.4.1.207; Evidence={ECO:0000255|RuleBase:RU361120, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is between 4.5-6.5. Loses activity rapidly when pH is lowered from 5 to 4. {ECO:0000269|PubMed:25849978}; | null | FUNCTION: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Probably involved in cell wall restructuring during fruit ripening and postharvest fruit softening. {ECO:0000269|PubMed:25849978}. | Diospyros kaki (Kaki persimmon) (Diospyros chinensis) |
G5DBJ0 | CPP1_NICBE | MATTLISKLTLSSAFLGQQFSSRGNSMRSAPAGLFLRGPRCAATDTPYGGNIPQFPRVNVWDPYKRLGISRDASEEEVWSSRNFLLNQYYNHERSAESIEAAFEKILMASFINRKKTKINLKTRLKKKVEESPPWVQNLLSFVELPPPVIILRRLFLFGFMACWSVMNSTEAGPAFQVAISFGACVYFLNDKTKSLGRAALIGFGALVAGWFCGSLLVPMIPPNLLHPTWSLELLTSLFIYVSLFLGCTFLK | null | null | chaperone-mediated protein folding [GO:0061077]; chloroplast organization [GO:0009658]; de-etiolation [GO:0009704]; protein folding [GO:0006457] | chloroplast envelope [GO:0009941]; chloroplast membrane [GO:0031969]; chloroplast thylakoid membrane [GO:0009535]; plastid thylakoid membrane [GO:0055035] | protein folding chaperone [GO:0044183] | PF11833; | null | Chaperone-like protein of POR1 protein family | null | SUBCELLULAR LOCATION: Plastid, chloroplast envelope {ECO:0000269|PubMed:24151298}. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:24151298}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Exhibits holdase chaperone activity involved in the stabilization of POR proteins against photooxidative stress in chloroplasts. Required for chloroplast development. {ECO:0000269|PubMed:24151298}. | Nicotiana benthamiana |
G5DDC2 | ADH1B_MAIZE | MMASQAMVPLRQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWARAPGAVRAKYLRAIAAKVIERKQELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKVAPALAAGCAAVLKPSELASVTCLELADICKEVGLPPGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKKIMAAAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLVHTKIAKEFNEKMVAW... | 1.2.1.-; 1.2.1.19; 1.2.1.47; 1.2.1.54; 1.2.1.8 | null | cellular detoxification of aldehyde [GO:0110095]; glycine betaine biosynthetic process from choline [GO:0019285] | null | 1-pyrroline dehydrogenase activity [GO:0033737]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; betaine-aldehyde dehydrogenase activity [GO:0008802]; gamma-guanidinobutyraldehyde dehydrogenase activity [GO:0047107]; protein homodimerization a... | PF00171; | null | Aldehyde dehydrogenase family | null | null | CATALYTIC ACTIVITY: Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; Evidence={ECO:0000269|PubMed:23408433}; PhysiologicalDirection=left-to-right... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=26 uM for 4-aminobutanal {ECO:0000269|PubMed:23408433}; KM=11 uM for 3-aminopropanal {ECO:0000269|PubMed:23408433}; KM=10 uM for 4-(trimethylamino)butanal {ECO:0000269|PubMed:23408433}; KM=5 uM for 4-guanidinobutanal {ECO:0000269|PubMed:23408433}; KM=29 uM for beta... | PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. {ECO:0000305}. | null | null | FUNCTION: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:23408433). Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (P... | Zea mays (Maize) |
G5E5X0 | LIMD1_BOVIN | MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQQQQQLLQEETLPRASRGPINGGARLGPPAHREAGGGSKLAADGAAKPPLAASTVAPGTTITVAPGQPSYPPQEQRAKLYVRGSRQGSQDCGSKESMVNSEMSAFHRPGPCEDPSCLTHGDYYDNLSLAGPKWADDPGVSPGIRLGVGSGWSGTPGSDPLLSKPSRDPHLYHQQLSAGSGRSLQSGQDGGPGGGNSEKPAGVWTTASSQRVSPGLPSAGPENGALPRSAQPRTPSFSAPLALNRPSQGSLPRTNSGVGSEV... | null | null | cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0... | adherens junction [GO:0005912]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667] | metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] | PF00412; | 2.10.110.10; | Zyxin/ajuba family | PTM: Phosphorylated during mitosis. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nu... | null | null | null | null | null | FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positi... | Bos taurus (Bovine) |
G5E829 | AT2B1_MOUSE | MGDMANNSVAYSGVKNSLKEANHDGDFGITLTELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENR... | 7.2.2.10 | null | calcium ion export [GO:1901660]; calcium ion export across plasma membrane [GO:1990034]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regu... | apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; immunological syn... | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] | PF12424;PF13246;PF00689;PF00690;PF00122;PF00702; | 3.40.1110.10;2.70.150.10;1.20.1110.10;3.40.50.1000; | Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20020}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23460639}. Synapse {ECO:0000269|PubMed:12209837}. Presynaptic cell membrane {ECO:0000269|PubMed:30862855}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic v... | CATALYTIC ACTIVITY: Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence={ECO:0000305|PubMed:24805951, ECO:0000305|PubMed:30862855}; Physiolog... | null | null | null | null | FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:16956963, PubMed:22311909, PubMed:23266958, PubMed:24805951, PubMed:26392310, PubMed:28827723, PubMed:29950683). Plays a role in blo... | Mus musculus (Mouse) |
G5E870 | TRIPC_MOUSE | MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESFSETNKPHSKSKKRHLDQEQQLKSAQLPSTSKAHTRKSVAAGSSRNQKRKRTESSCVKSGSGSESTGAEERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIASASSTVPAGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPPAELPSL... | 2.3.2.26 | null | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development... | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] | ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | PF00632;PF02825; | 3.30.720.50;3.30.2410.10;3.90.1750.10;1.25.10.10; | UPL family, K-HECT subfamily | null | SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q14669}. | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence={ECO:0000250|UniProtKB:Q14669}; | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q14669}. | null | null | FUNCTION: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts... | Mus musculus (Mouse) |
G5E8I7 | U17LC_MOUSE | MVVSLSFPEADPALSSPGAQQLHQDEAQVVVELTANDKPSLSWECPQGPGCGLQNTGNSCYLNAALQCLTHTPPLADYMLSQEYSQTCCSPEGCKMCAMEAHVTQSLLHSHSGDVMKPSQILTSAFHKHQQEDAHEFLMFTLETMHESCLQVHRQSEPTSEDSSPIHDIFGGLWRSQIKCLHCQGTSDTYDRFLDVPLDISSAQSVNQALWDTEKSEELRGENAYYCGRCRQKMPASKTLHIHSAPKVLLLVLKRFSAFMGNKLDRKVSYPEFLDLKPYLSQPTGGPLPYALYAVLVHEGATCHSGHYFSYVKARHGAWY... | 3.4.19.12 | null | chordate embryonic development [GO:0043009]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843] | PF00443; | 3.90.70.10; | Peptidase C19 family, USP17 subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6R6M4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6R6M4}. | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:11443643, ECO:0000269|PubMed:8995226}; | null | null | null | null | FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes (PubMed:11443643, PubMed:8995226). Important for preimplantation stage embryonic development (PubMed:22984479). {ECO:0000269|PubMed:11443643, ECO:0000269|PubMed:22984479, ECO:0000269|PubMe... | Mus musculus (Mouse) |
G5E8K5 | ANK3_MOUSE | MSEEPKEKPAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRSAPILSKTKNGLSP... | null | null | anterograde axonal transport [GO:0008089]; axon development [GO:0061564]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; clustering of voltage-gated sodium channels [GO:0045162]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; magn... | axon [GO:0030424]; axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; costamere [GO:0043034]; dendrite [GO:0030425]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; paranode region of... | cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; phosphorylation-dependent protein binding [GO:0140031]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; transmembrane transporter binding [GO:0044325] | PF00023;PF12796;PF13637;PF00531;PF17809;PF00791; | 2.60.220.30;2.60.40.2660;1.25.40.20;1.10.533.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12955}. Cell projection, axon {ECO:0000250|UniProtKB:O70511}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q12955}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O70511}. Lysosome {ECO:0000269|PubMed:9060470}. Cell membrane, sarcolemma, T-tub... | null | null | null | null | null | FUNCTION: Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (PubMed:19109891). Regulates KCNA1 channel act... | Mus musculus (Mouse) |
G5E8P1 | BRD1_MOUSE | MRRKGRCHRGSAARHPSSPCSIKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEVLPSTHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIINEKRKGDCVSAVSQNMFEFLMDRFEKESYCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPP... | null | null | erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]; response ... | dendrite [GO:0030425]; histone H3-K14 acetyltransferase complex [GO:0036409]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perikaryon [GO:0043204] | histone binding [GO:0042393]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872] | PF00439;PF10513;PF13831;PF00855;PF13832; | 2.30.30.140;1.20.920.10;3.30.40.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95696}. Chromosome {ECO:0000250|UniProtKB:O95696}. Note=Localizes to transcription start sites. {ECO:0000250|UniProtKB:O95696}. | null | null | null | null | null | FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:21753189). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting ... | Mus musculus (Mouse) |
G5E8Q8 | AGRF5_MOUSE | MRSPRTFTFYFLLLVICSSEAALSTPTEPIVQPSILQEHELAGEELLRPKRAAAAGDRVAEEYMVDIEISFENVSFLESIRAHLNNLSFPIRGTEADILNIAMTTVCTPAGNDLLCFCEKGYQWSEERCLHSLTCQDYDSALPGGYCSCLKGLPPQGPFCQLPEAFITLKLKVRLNIGFQEDLKNTSSALYRSYKTDLERAFRAGYRTLPGFRSVTVTQFTKGSVVVNYVVRVTSAPLPGSIHKANEQVIQNLNHTYKMDYNSFQGTPSNETKFTVIPEFIFEGDNVTLECETEFVTSNTSWYYGEKRSDIQNSDKYSIH... | null | null | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; glomerular filtration [GO:0003094]; glucose homeostasi... | apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] | G protein-coupled receptor activity [GO:0004930] | PF00002;PF16489;PF01825;PF00047;PF01390; | 2.60.220.50;2.60.40.10;1.20.1070.10; | G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily | PTM: Highly glycosylated. {ECO:0000250|UniProtKB:Q9WVT0}.; PTM: Proteolytically cleaved at multiple sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteol... | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WVT0}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Receptor that plays a critical role in lung surfactant homeostasis (PubMed:23590306, PubMed:23684610, PubMed:23922714). May play a role in controlling adipocyte function (PubMed:22971422). {ECO:0000269|PubMed:22971422, ECO:0000269|PubMed:23590306, ECO:0000269|PubMed:23684610, ECO:0000269|PubMed:23922714}. | Mus musculus (Mouse) |
G5E8Z2 | TAF4B_MOUSE | MPAGLTEPAGAAAPVVSSASGAVTMAPVAALPVRVEGTPVALGPVTKAPVSVCVESVAPQPLPAPVGTLVTKVVPVTALPKLGSPRLPAPQIVTVKTPGTTTIQLPANLQLPPGTVLIKSNSGQLMLVSPQQAVTGAKTTSNITPRPAVPANTQTVKICTVPNSSSQLMKKVTVAPVKNLTQIGTTVATTASSTSSGQPVALPSSVITVTPAKLVNTVSTLKSSSLGVLSTPSNDARLKAETSVAAQTALPPTVLENVKKCKNFLSMLIKLACSGSQSPEMGQNVKRLVEQLLDAEIEAEEFTRKLYIELKSAPQPHLVP... | null | null | mRNA transcription by RNA polymerase II [GO:0042789]; oogenesis [GO:0048477]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation com... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667] | DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251] | PF05236;PF07531; | 1.10.20.10;1.20.120.1110; | TAF4 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92750}. Cytoplasm {ECO:0000250|UniProtKB:Q92750}. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000250|UniProtKB:Q92750}. | null | null | null | null | null | FUNCTION: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators asond repressors. TAF4B is a transcriptional coactivato... | Mus musculus (Mouse) |
G5EB19 | PPOA_EMENI | MGEDKETNILAGLGNTISQVENVVAASLRPLPTATGDGTYVAESTQTGLAKDLSHVDLKDVRTLAEVVKSAATGEPVDDKQYIMERVIQLAAGLPSTSRNAAELTKSFLNMLWNDLEHPPVSYLGADSMHRKADGSGNNRFWPQLGAAGSAYARSVRPKTMQSPSLPDPETIFDCLLRRKEYREHPNKISSVLFYLASIIIHDLFQTDPKDNSVSKTSSYLDLSPLYGNNQDEQNLVRTFKDGKLKPDCFATKRVLGFPPGVGVLLIMFNRFHNYVVDQLAAINECGRFTKPDESNVDEYAKYDNNLFQTGRLVTCGLYA... | 1.13.11.60; 5.4.4.5 | COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250}; | asexual sporulation resulting in formation of a cellular spore [GO:0043936]; fatty acid metabolic process [GO:0006631]; negative regulation of sexual sporulation resulting in formation of a cellular spore [GO:0043942]; oxylipin biosynthetic process [GO:0031408]; penicillin metabolic process [GO:0042316]; positive regul... | null | dioxygenase activity [GO:0051213]; fatty acid peroxidase activity [GO:0047888]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleate 8R-lipoxygenase activity [GO:0052878]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorpor... | PF03098;PF00067; | 1.10.630.10;1.10.640.10; | Peroxidase family | null | null | CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate; Xref=Rhea:RHEA:25395, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:58659; EC=1.13.11.60; CATALYTIC ACTIVITY: Reaction=(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca... | null | null | null | null | FUNCTION: Bifunctional heme-containing enzyme that oxidizes linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (within the N-terminal heme peroxidase domain), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (within the C-terminal P450 heme thiolate domain). Oxidized ... | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
G5EB30 | CHIA1_EMENI | MAPKLFTFVSALSGLASLASAFHAEAKSNIAVYYGQGVNQPRLAEFCAETSYDIINIGFINSFPEQNPLTGLPGSDFGNQCWADTFVVDGIASQLYSHCPNIAEDIPKCQAAGKKVFLSLGGATPTYWFDTIDASTKLADFLWGAFGPVTDAWTVADKPRPFGNAVVDGFDFDIEFFGSKGYANMIKRFRRRFGEVPDQTFYISAAPQCSIPDEQLSVAIKNAVIDFVWVQFYNTPGCSARDFVLGTKNGFNYDSWVEVIKAGANPNAKLYVGLPASGAAANLGYYLTPEEVKPLVKKYMDKYPETFGGVMLWEATQARN... | 3.2.1.14 | null | chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] | cell tip [GO:0051286]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] | chitin binding [GO:0008061]; chitinase activity [GO:0004568] | PF00704; | 3.20.20.80; | Glycosyl hydrolase 18 family, Chitinase class III subfamily | PTM: O-glycosylated but not N-glycosylated. {ECO:0000269|PubMed:18420434}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18420434}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18420434}. Secreted, cell wall {ECO:0000250}. Cell tip {ECO:0000269|PubMed:18420434}. Note=Localizes at the germ tubes of conidia, at hyphal branching sites and hyphal tips. | CATALYTIC ACTIVITY: Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14; Evidence={ECO:0000269|PubMed:18420434}; | null | null | null | null | FUNCTION: GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as site... | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
G5EB37 | CHMU_EMENI | MDTAIDLSDASKALDLANIRFQLIRLEDTITFHLIERVQFPLNKTIYIPGGVKIPNEQISLMDYLLRETERLQSRVRRYQSPDEYPFFPSALEKPILQPLDYPKILHDNDVNVNETIKTRYVQDILPAICPQFGGREDRGETQENYGSAATCDVSCLQALSRRIHFGKFVAESKFQKETEKFVALIKAGDRKEIDEAITDAKVEQKVLERLALKAKTYGTDPGFPEQSGPKIDVQAVQDMYKEYVIPLTKVVEVEYLMQRLKGTQWE | 5.4.99.5 | null | aromatic amino acid family biosynthetic process [GO:0009073]; chorismate metabolic process [GO:0046417]; L-phenylalanine biosynthetic process [GO:0009094]; sporocarp development involved in sexual reproduction [GO:0000909]; tyrosine biosynthetic process [GO:0006571] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | chorismate mutase activity [GO:0004106]; tryptophan binding [GO:0120284]; tyrosine binding [GO:0072545] | null | 1.10.590.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32178}. | CATALYTIC ACTIVITY: Reaction=chorismate = prephenate; Xref=Rhea:RHEA:13897, ChEBI:CHEBI:29748, ChEBI:CHEBI:29934; EC=5.4.99.5; Evidence={ECO:0000269|PubMed:10428795}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13898; Evidence={ECO:0000269|PubMed:10428795}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 mM for chorismate (in the presence of 5 uM tryptophan and at 30 degrees Celsius); Note=kcat is 82 sec(-1) with chorismate as substrate (at 30 degrees Celsius). kcat is 92 sec(-1) with chorismate as substrate (in the presence of 5 uM tryptophan and at 30 degrees... | PATHWAY: Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1. {ECO:0000305|PubMed:10428795}. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5.9 in the absence of effectors. Optimum pH is 7.1 in the presence of tryptophan. Optimum pH is 5.4 in the presence of tyrosine. Tryptophan broadens the pH range of detectable catalytic activity. {ECO:0000269|PubMed:10428795}; | null | FUNCTION: Catalyzes the Claisen rearrangement of chorismate to prephenate (PubMed:10428795). Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (By similarity). {ECO:0000250|UniProtKB:P32178, ECO:0000269|PubMed:1042... | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
G5EB89 | KAPA_EMENI | MAERYIPEHRRTQYKARNQFRPDELRRRREEQQVEIRKQKREENLAKRRGIQTRDGGIGVGGGMAAAESDDEASAIESELNVELPEMVKGVFSDQIEAQIQATTKFRKLLSKERNPPIERVIETGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSPEPDVREQAVWALGNIAGDSPQCRDFVLNAGALRPLLTLINDGRKISMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLIYMLDDEVLIDACWAISYLSDGPNEKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGN... | null | null | NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] | PF00514;PF16186;PF01749; | 1.20.5.690;1.25.10.10; | Importin alpha family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B6HJ92}. | null | null | null | null | null | FUNCTION: Import of proteins with classical NLS composed of one or two clusters of basic residues is initiated by binding to the importin alpha/beta heterodimer, where importin alpha acts as an adapter subunit to bridge NLS cargos to importin beta, which transports the whole complex through the nuclear envelope (PubMed... | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
G5EBF1 | SAX3_CAEEL | MFNRKTLLCTILLVLQAVIRSFCEDASNLAPVIIEHPIDVVVSRGSPATLNCGAKPSTAKITWYKDGQPVITNKEQVNSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEVKSNEGSLKLAMLREDFRVRPRTVQALGGEMAVLECSPPRGFPEPVVSWRKDDKELRIQDMPRYTLHSDGNLIIDPVDRSDSGTYQCVANNMVGERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVTGDPQPQITWKRKNEPMPVTRAYIAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQ... | null | null | cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; neuron migration [GO:0001764]; regulation of sensory neuron axon guidance [GO:1905489]; Roundabout signaling pathway [GO:0035385]; sensory neuron axon guidance [GO:0097374] | cytosol [GO:0005829]; plasma membrane [GO:0005886] | axon guidance receptor activity [GO:0008046] | PF00041;PF07679;PF13927; | 2.60.40.10; | Immunoglobulin superfamily, ROBO/SAX3 family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. | null | null | null | null | null | FUNCTION: Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. {ECO:0000269|PubMed:10993679, ECO:0000269|PubMed:9458046}. | Caenorhabditis elegans |
G5EBH0 | PLCB_CAEEL | MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFL... | 3.1.4.11 | COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:P10688}; | chemotaxis [GO:0006935]; dopamine receptor signaling pathway [GO:0007212]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation ... | adherens junction [GO:0005912]; axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202] | calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] | PF00168;PF06631;PF09279;PF17787;PF00388;PF00387; | 2.30.29.240;2.60.40.150;1.10.238.10;3.20.20.190;1.20.1230.10; | null | null | SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:10571227}. Cell projection, axon {ECO:0000269|PubMed:10571227}. Synapse {ECO:0000269|PubMed:10571227}. Cell junction, adherens junction {ECO:0000269|PubMed:10571227}. Note=Present in neuronal cell somas and axon processes of the nerve ring in head ganglia. Present in... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence={EC... | null | null | null | null | FUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmis... | Caenorhabditis elegans |
G5EBH1 | TAT5_CAEEL | MGKRKKNDESSSSSSQKPCVSSSSDDFSVSFVRAEEDDVATTIRDKTASLKSNATHFSAASAAKGGMFDFRCCRSLFSRRRVLHSRTVRVGYGPVGHDANVTFTPNTVCNQKYNIFSFVPIVLFQQFKFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEKYEKLTRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRIPVPHTQHLPNEADIMELNCEVYAEKPQKDIHAFVGTLKITDDDNVQDGSLNVENVLWANTVVASGTA... | 7.6.2.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P40527}; | embryo development ending in birth or egg hatching [GO:0009792]; endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; reproduction [GO:0000003]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] | PF13246;PF00122;PF00702;PF16212;PF16209; | 3.40.1110.10;2.70.150.10;3.40.50.1000; | Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22100064}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence={ECO:0000305|PubMed:30213940}; | null | null | null | null | FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins during embryogenesis (PubMed:22100064, PubMed:30213940). Regulates snx-3 retromer-mediated endosomal sorting of mig-14, a transporter of Wnt egl-20 morphogen (PubMed:30213940). Together with mon-2 and pad-1, may participate in the formation of ... | Caenorhabditis elegans |
G5EBI4 | CEEH1_CAEEL | MLFESIYIQCLNKFSKYKKFVCHTTCNCPNYKIIGYLLYFLCLCRPINCSLPLSRHDLAFGSFSYYLTMFLYRILVRLLQFYYFVKFSAILFLGFAVKGRSLFEKKQREKPNVLEGWDSRYIKLKKVRLHYVQTGSDDKPLMLFIHGYPEFWYSWRFQLKEFADKYRCVAIDQRGYNLSDKPKHVDNYSIDELTGDIRDVIEGLGYDKAIVVAHDWGGLVAWQFAEQYPEMVDKLICCNIPRPGSFRKRIYTSWSQFRKSWYMFFYQNEKIPEMLCSADDMKMLELCFRAKEIGIQNNKNFTDEDLEAWKYSFSMNGASF... | 3.3.2.10 | null | cellular lipid metabolic process [GO:0044255] | membrane [GO:0016020] | epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787] | PF00561; | 3.40.50.1820; | AB hydrolase superfamily, Epoxide hydrolase family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=an epoxide + H2O = an ethanediol; Xref=Rhea:RHEA:19037, ChEBI:CHEBI:15377, ChEBI:CHEBI:32955, ChEBI:CHEBI:140594; EC=3.3.2.10; Evidence={ECO:0000269|PubMed:18267101}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19038; Evidence={ECO:0000305|PubMed:18267101}; CATALYTIC ACTIVITY: Reac... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=160 uM for trans-1,3-diphenylpropene oxide {ECO:0000269|PubMed:18267101}; KM=11.4 uM for 12,13-epoxy-9-octadecenoate {ECO:0000269|PubMed:18267101}; KM=7.5 uM for 9,10-epoxy-12-octadecenoate {ECO:0000269|PubMed:18267101}; Note=kcat is 12 sec(-1) with trans-1,3-diphe... | PATHWAY: Lipid metabolism. {ECO:0000305|PubMed:18267101}. | null | null | FUNCTION: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active against epoxyeicosatrienoic acids (EETs) including 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (8,9-EET), 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate (11,12-EET) and 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate (14,15-EET) and the linoleic acid metabolites ... | Caenorhabditis elegans |
G5EBK1 | PBO4_CAEEL | MWIKLLFFFTTLLVSTSGLGDDGITALLDPNSTEFSTVLPSNNSEKFSYMLASVKNMNMTASEFEEFIKVLKHRQSKDHSGEHVGNEHDESHGISVVSWHWDYVKNELVLTLFFIVIGLFKLVYHHTFVTRKILPESCCLIFIGIAIGFFFVGDATHASIKFLEFKSKVFFFYLLPPIILESAYSLKDRAFIENIGTILLYAVVGTILNIVLLAAALLILIWVGIMGKYNLSVMDILTFASLVAAVDPVAVLAVFQEVGVNKMLYFMVFGESLFNDAVTIVCYNLAIEFQTLPDFTWYHGFLGLLSFLCVSIGGLIIGLI... | null | null | defecation [GO:0030421]; lipid transport involved in lipid storage [GO:0010877]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion transmembrane transport [GO:0071805]; regulation of cellular pH [GO:0030641]; regulation of int... | basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] | calmodulin binding [GO:0005516]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] | PF00999; | 6.10.140.1330; | Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | null | SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:18191228, ECO:0000269|PubMed:23319594}; Multi-pass membrane protein {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:18191228, ECO:0000269|PubMed:23319594}. | null | null | null | null | null | FUNCTION: Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation (PubMed:18191228, PubMed:18291648, PubMed:23319594). Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal c... | Caenorhabditis elegans |
G5EBL2 | MES1_CAEEL | MKIHHFLTLLCTFLPLTTTALTNSTPLSLLGPCYKRCVTKFGETKEQLTNAETISLEYDVSNNTEFSLCKLGCNSHEYTDLNLAAFRYGQLAYQKILTTVEDVPTRGTVLNDVFIVCLDTSFMPSNNSAPSAKRLLSGTVLLVLDEDVAKADNVFLIEVLARNADKSAVQVISQQWCYSSNCNITFNAPTEVSSFDVRLRVSTFDSNGQVGGINFSKWHNINQILTKTFVDMSLKSVVWKAEKAAANFVFNLTASDHVPACSLQMIYRSSLSSELLHRNFYLDHTLEVFVNNLDFDKIYTMQLAPSGTHDRSTPSLASAV... | null | null | asymmetric cell division [GO:0008356]; asymmetric protein localization involved in cell fate determination [GO:0045167]; cell fate specification [GO:0001708]; developmental process involved in reproduction [GO:0003006]; embryonic digestive tract morphogenesis [GO:0048557]; establishment of mitotic spindle localization ... | centrosome [GO:0005813]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713] | PF07714; | 1.10.510.10; | Protein kinase superfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11003841, ECO:0000269|PubMed:12110172}; Single-pass type I membrane protein {ECO:0000305}. Note=Localizes at the site of contact between EMS and P2 cells in the 4-cell stage embryo, between P3 and E cells in the 12-cell stage embryo and between P4 and Ep cells in ... | null | null | null | null | null | FUNCTION: During early embryogenesis, controls asymmetric cell division and the asymmetric localization of P granules of germline precursor P2 and its descendant P3 (PubMed:7555722). Probably upstream of tyrosine kinase src-1, plays a role in endoderm development by controlling spindle orientation during EMS blastomere... | Caenorhabditis elegans |
G5EBL3 | SDC2_CAEEL | MSDESELGNQSEMESFNESDSPDEADPDVVIIHDIVHLRASTTGDYSQSEIGKLPEQNTFFLPGRVKRNISSNDSDVIIDEDEIPDGAIRITSDTHFIGSSRGTSELGDFEMDEQEFLNITIEENGNEQELEEHLRNAYRHEEEECFEEEDDIIELPPLPVKPAVKKPRRKLPKHLSIESGSTAKTSKLVAEVVHDHPRPVNYRMKPAVTDDGKVVEQKRTRVTRNIMSHTIPQYHLEGEETEFGRVKESTLSKTIEQYLQAGKLVSPKCDQFREQIVATAVEYDGSVKMLQFENALKKHSGKQKRLKYQTGWWKASKSH... | null | null | cell differentiation [GO:0030154]; dosage compensation by hypoactivation of X chromosome [GO:0042464]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sex determination [GO:0007530]; sex differentiation [GO:0007548] | nuclear chromosome [GO:0000228]; X chromosome [GO:0000805] | null | null | null | null | null | SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:10364546}. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos. {ECO:0000269|PubMed:10364546}. | null | null | null | null | null | FUNCTION: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:10364546, PubMed:2759421). Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her... | Caenorhabditis elegans |
G5EBM1 | CSP1_CAEEL | MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRTDAKKSNHKHKYCYEMNSNPRGTVLILSNENFKNMERRVGTKQDEVNLT... | 3.4.22.36 | null | activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; negative regulation of cellular response to manganese ion [GO:1905803]; positive regulation of apoptotic process involved in development [GO:1904747]; positive regulation of cellular response to gamma radiation [GO:1905845]... | germ cell nucleus [GO:0043073] | cysteine-type endopeptidase activity [GO:0004197] | PF00656;PF04435; | 3.40.50.1460; | Peptidase C14A family | PTM: Autocatalytic cleavage removes the propeptide and generates the two active subunits p16 and p14 in vitro. Cannot be cleaved by ced-3 in vitro. {ECO:0000269|PubMed:9857046}. | null | CATALYTIC ACTIVITY: Reaction=Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.; EC=3.4.22.36; Evidence={ECO:0000269|PubMed:9857046}; | null | null | null | null | FUNCTION: Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms (PubMed:9857046). Also cleaves, in vitro, inactive caspase csp-2 isoform b (PubMed:9857046). Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently o... | Caenorhabditis elegans |
G5EBN9 | SNF3_CAEEL | MGTSEHVPLPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMWLMCPLFRGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATCVTGKENFTELARIKALVASAGGHTQTSVEQFWEKRVLHDTGDISEFGGIQWELFFIMAAAWLIVYFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFKDAIT... | null | null | amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725] | neuron projection [GO:0043005]; plasma membrane [GO:0005886] | amino-acid betaine transmembrane transporter activity [GO:0015199]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] | PF00209; | null | Sodium:neurotransmitter symporter (SNF) family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24212673}; Multi-pass membrane protein {ECO:0000305|PubMed:24212673}. | null | null | null | null | null | FUNCTION: Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine. {ECO:0000269|PubMed:24212673}. | Caenorhabditis elegans |
G5EBQ8 | CHS2_CAEEL | MMNTLDHRPLGRMETMEGKPDEDEVPTSSNSDAKGKGYYYSSGTVPTDDSTLEEKCQQKTFDPSCPTPKTPVIVPNREFDPNFSTVTENKGWDIFRLLPPKPDRLGHGFWHDASLQVLKLATFLVLFLLTLGSAVVAKSTFILMTSAIGWGGQTITICNQVISEATQNTVKLKNAHVVKWVWATLLALSAPEALCFVRSMHRTMFRNVKRPTFIQFVFVLIIETFHSIGVGILVFRIFPDLDAVTAAQLTNAMCFVPAILSVISRKPNKSALLLVIIDFAAIAAQSSGFWALPMFLPNLQKHLVAIPVSLTLISLAWWQN... | 2.4.1.16 | null | cell wall chitin biosynthetic process [GO:0006038]; chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063] | cell periphery [GO:0071944]; cell septum [GO:0030428]; plasma membrane [GO:0005886] | chitin synthase activity [GO:0004100] | PF03142; | null | Chitin synthase family, Class IV subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:16098962}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595, ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223; EC=2.4.1.16; Evi... | null | null | null | null | FUNCTION: May be involved in chitin synthesis in the pharynx during larval development. {ECO:0000269|PubMed:16098962}. | Caenorhabditis elegans |
G5EBR3 | GLUCL_CAEEL | MATWIVGKLIIASLILGIQAQQARTKSQDIFEDDNDNGTTTLESLARLTSPIHIPIEQPQTSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQ... | null | null | chloride transmembrane transport [GO:1902476]; locomotion involved in locomotory behavior [GO:0031987]; protein complex oligomerization [GO:0051259] | neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] | extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate binding [GO:0016595]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulatio... | PF02931;PF02932; | 2.70.170.10;1.20.58.390; | Ligand-gated ion channel (TC 1.A.9) family, Glutamate-gated chloride channel (TC 1.A.9.4) subfamily | null | SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q94900}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q94900}. Cell membrane {ECO:0000255, ECO:0000269|PubMed:21572436, ECO:0000269|PubMed:25143115, ECO:0000269|PubMed:7935817}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:215... | null | null | null | null | null | FUNCTION: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configura... | Caenorhabditis elegans |
G5EBT1 | SMA5_CAEEL | MVFADFLEKIKSLFAKTKDPITSMSPPQENRSPKAEYLNNFFNTNPTNGKSRGSQEAPRKPLGQTNLNVQGSMPAKKEGFNRVLDGLKKRQLQHDFKLERAAETYEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLGIDVFLVMDLMQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVGCIFGEMVIRNEILPGRS... | 2.7.11.24 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q13164}; | cell population proliferation [GO:0008283]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; intracellular signal transduction [GO:0035556]; nematode larval development [GO:0002119]; organelle localization [GO:0051640]; parturition [GO:0007567]; phosphorylation [GO:0016310]; positive... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000250|UniProtKB:Q13164}; CATALYT... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase involved in the postembryonic regulation of body size, mainly through control of cell growth. In particular, controls the volume of intestine, muscles and hypodermis. In addition, regulates growth, intestinal granule distribution, lifespan and number of offspring. {ECO:0000269|... | Caenorhabditis elegans |
G5EBU3 | MMPC_CAEEL | MRLIYVIAILLVSTCQAGFFSSLVSRFTGGGNSSPSSSSSSSSFSNSRKPSLSDEKARSYLQTFGYVPPSNSLQSRNGMAGDIQSAEQVFKSAIRKFQEFAGIAKTGFLDAATKAKMALSRCGVTDAPLALTSGSSQFKWSKTRLTYSIESWSSDLSKDDVRRAISEAYGLWSKVTPLEFSEVPAGSTSDIKIRFGVRNHNDPWPFDGEGGVLAHATMPESGMFHFDDDENWTYKDARKIHNNEATDLLAVAIHEGGHTLGLEHSRDENAIMAPFYQKTTDSSGNYVYPNLKSDDISAIQAIYGAGSGRSSSGSDFGGSS... | 3.4.24.- | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P03956}; | collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] | extracellular matrix [GO:0031012]; extracellular space [GO:0005615] | metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] | PF00413; | 3.40.390.10;2.110.10.10; | Peptidase M10A family | null | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. | null | null | null | null | null | FUNCTION: Metalloproteinase. {ECO:0000269|PubMed:9573338}. | Caenorhabditis elegans |
G5EBU4 | ZAG1_CAEEL | MVDIAEAMPTTASSLPSDEALRKFKCPECTKAFKFKHHLKEHIRIHSGEKPFECQQCHKRFSHSGSYSSHMSSKKCVQQASPSMVTPFNPYQLMMYRNIMLQLQTPQVSFLPSTAANNMDYMSLLQANLFQSLENGTSPTPTQEPSAPASPEPKIEVVDEPEVSSEVKTEVKTEVKTEDSVPEESITPAVSMSLSPAPEQNGNESMNNGGSGSDGKSSPDWRPLRSRSFLNDSQVAVLQNHFKRNPFPSKYELSAVAEQIGVNKRVVQVWFQNTRAKERRSNRLPSMPRGSVASAAAAAATSPTVWQTPVQLMAAWASQF... | null | null | axon guidance [GO:0007411]; dendrite development [GO:0016358]; larval development [GO:0002164]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; positive regulation of axon extension [GO:0045773]; regulation of neuron differentiation [GO:0045664]; regulatio... | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00046;PF00096; | 3.30.160.60;1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12835394}. | null | null | null | null | null | FUNCTION: Transcription factor (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162). Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA (PubMed:12835394). Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspe... | Caenorhabditis elegans |
G5EBV0 | EGL9_CAEEL | MSSAPNDDCEIDKGTPSTASLFTTLMLSQPSSSTAVLQCTYCGSSCTSSQLQTCLFCGTVAYCSKEHQQLDWLTHKMICKSLQTSGMVPSNLMPQAAPAVMAPIPPTVSFDDPALTTSLLLSLQNNPILNQTISNFPPTFSITSKTEPEPSIPIQIPQRISSTSTVPFSSEGSAFKPYRNTHVFNSISSESMSSMCTSHEASLEHMSSASLAMFPTSSTAQSDISRLAQVLSLAGDSPASLALVTTSVPSTASTATIPPPATTTSSATSSGKSETITVGKEKIIQTDDPDIQIIETEGGSKPTVSRTRKRPTPSNSADPK... | 1.14.11.29 | COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:19737748}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE-ProRule:PRU00805}; COFACTOR: Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000269|PubMed:11595184}; | cellular response to hypoxia [GO:0071456]; regulation of protein localization [GO:0032880]; response to hypoxia [GO:0001666] | axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634] | ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545] | PF13640;PF01753; | 6.10.140.2220;2.60.120.620; | null | null | SUBCELLULAR LOCATION: [Isoform a]: Cytoplasm {ECO:0000269|PubMed:22252129}. Nucleus {ECO:0000269|PubMed:22252129}. Cell projection, dendrite {ECO:0000269|PubMed:22252129}. Note=In interneurons, localizes throughout the ventral cord dendrites. {ECO:0000269|PubMed:22252129}.; SUBCELLULAR LOCATION: [Isoform c]: Cytoplasm ... | CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA-COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHE... | null | null | null | null | FUNCTION: Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation (PubMed:11595184). In addition, regulates hif-1 transcriptional activity in a vhl-1-indepen... | Caenorhabditis elegans |
G5EBV6 | PGL3_CAEEL | MEANKRQIVEVDGIKSYFFPHLAHYLASNDELLVNNIAQANKLAAFVLGATDKRPSNEEIAEMILPNDSSAYVLAAGMDVCLILGDDFRPKFDSGAEKLSQLGQAHDLAPIIDDEKKISMLARKTKLKKSNDAKILQVLLKVLGAEEAEEKFVELSELSSALDLDFDVYVLAKLLGFASEELQEEIEIIRDNVTDAFEACKPLLKKLMIEGPKIDSVDPFTQLLLTPQEESIEKAVSHIVARFEEASAVEDDESLVLKSQLGYQLIFLVVRSLADGKRDASRTIQSLMPSSVRAEVFPGLQRSVFKSAVFLASHIIQVFL... | 4.6.1.24 | null | null | intracellular organelle [GO:0043229]; P granule [GO:0043186] | identical protein binding [GO:0042802]; lyase activity [GO:0016829]; ribonuclease T1 activity [GO:0046589]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521] | null | null | null | PTM: Methylated at arginine residues in the RNA-binding RGG-box by prmt-1. Methylation promotes P-granule degradation by autophagy. {ECO:0000269|PubMed:24140420}. | SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:15238518, ECO:0000269|PubMed:19372764, ECO:0000269|PubMed:21402787, ECO:0000269|PubMed:24140420, ECO:0000269|PubMed:26598553, ECO:0000269|PubMed:27594427, ECO:0000269|PubMed:27650246, ECO:0000269|PubMed:28806108, ECO:0000305|PubMed:19167332}. Note=Localizes ... | CATALYTIC ACTIVITY: Reaction=[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].; EC=4.6.1.24; Evidence={ECO:0000269|PubMed:26787882}; | null | null | null | null | FUNCTION: Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate (PubMed:26787882). P-granule component involved in germl... | Caenorhabditis elegans |
G5EBX6 | EXOSX_CAEEL | MSGEESMPDEEQKQSEEEEEMIRKRTLAMRKKVEEIMRNGAGLVRESNGLPKAGADYELYNSYPTFNTFMKRSEQRLNALMNKVTKSIGCAMRVPDVGSSVEHYTECVIEAQDNIAERAATLHEALKKAELDEIVKVPEFITKAAPTNRKTEAEVSAAMRTFSANIGTVLAEKFRERREEAAQMVVLEKPQKTYNISSDNSQAPFSSKLTVKHHAIEKRTGIVLHDDDESGRRDWISAETETEEEHPYIAEILHFKVPEAQLKSAECLKFTALKDTPLTMIDTKEKLEALTKTLNSVKEFAVDLEHHQMRSYLGLTCLIQ... | 3.1.13.- | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q01780}; | apoptotic cell clearance [GO:0043277]; apoptotic DNA fragmentation [GO:0006309]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; histone mRNA catabolic process [GO:0071044]; nuclear polyadenylation-dependent antisense transcr... | exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | 3'-5'-RNA exonuclease activity [GO:0000175]; nucleotide binding [GO:0000166]; single-stranded RNA binding [GO:0003727] | PF01612;PF00570;PF08066; | 1.10.150.80;3.30.420.10; | Exosome component 10/RRP6 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34365510, ECO:0000269|PubMed:36763670}. Nucleus, nucleolus {ECO:0000269|PubMed:34365510, ECO:0000269|PubMed:36763670}. Nucleus, nucleoplasm {ECO:0000269|PubMed:36763670}. Note=As a part of exosome complex, translocates from the nucleolus to nucleoplasm in response to co... | null | null | null | null | null | FUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (By similarity). Involved in apoptotic DNA degradation (PubMed:12718884). Involved in regulation of antisense ribosomal siRNA production (P... | Caenorhabditis elegans |
G5EBX9 | PPE_CAEEL | MGCGPSSGRQNPSTELKKSTRATTTTTSSSQRNNYNDNNQNTSSSSGNKKESSSSSKQHSSKKSKKSNSKKNRSPSPQPQLTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHED... | 3.1.3.16 | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P36873}; Note=Binds 2 manganese ions per subunit. {ECO:0000250|UniProtKB:P36873}; | detection of stimulus involved in sensory perception [GO:0050906] | axon [GO:0030424]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722] | PF13499;PF00149;PF08321; | 3.60.21.10;1.10.238.10; | PPP phosphatase family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11312268}; Lipid-anchor {ECO:0000269|PubMed:11312268}. Perikaryon {ECO:0000269|PubMed:11312268}. Cell projection, dendrite {ECO:0000269|PubMed:11312268}. Cell projection, axon {ECO:0000269|PubMed:11312268}. Cell projection, cilium {ECO:0000269|PubMed:11312268}. | CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000255|RuleBase:RU004273}; CATALYTIC ACTIVITY: Reaction... | null | null | null | null | FUNCTION: Probably acts as a protein phosphatase. {ECO:0000305}. | Caenorhabditis elegans |
G5EBY8 | UN129_CAEEL | MRRLPIVLLLSVFSIANCAKVDVDLINETIRDLLHFKSSDPNVTSFHRSSHTLTEHMKNLYENFIDEDSNEDGNLVRAIEPAVGKFEGQEVLVFDVEGFDSHESIMRAELHFYLRRRDSFARRRSRQIRAKSVCVNEYCRQQTLKKIRVGGDENLEEYKVIWDATKSVFDSYHLDAKQAVFRITREHSKMRPYAEMIRKSTPFLVIYSKVNHTLDTVSVMKQTEQTKRKRRDLGNEELREYYNYNSIPLDNDDREPIKRKNGKKNSLSEEISSEDVWQGFGEETSREERERIANEELANDVRVVLLQNKNRCHKEGVLVS... | null | null | backward locomotion [GO:0043057]; dorsal/ventral axon guidance [GO:0033563]; inductive cell migration [GO:0040039]; locomotion [GO:0040011]; motor neuron axon guidance [GO:0008045]; nematode male tail tip morphogenesis [GO:0045138] | extracellular region [GO:0005576]; extracellular space [GO:0005615] | cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]; transforming growth factor beta receptor binding [GO:0005160] | PF00019; | 2.10.90.10; | TGF-beta family | null | SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:19169249}. | null | null | null | null | null | FUNCTION: Required for the migration of axonal growth-cones and distal tip cells (DTC) along the dorsal-ventral axis of the body wall (PubMed:19169249, PubMed:9473333, PubMed:9685266). Acts cell nonautonomously and independently of the classical daf-4, sma-6 or daf-1 TGFbeta receptor signaling (PubMed:11018016, PubMed:... | Caenorhabditis elegans |
G5EBZ4 | LE418_CAEEL | MSTEEDPSLVDAEESMEEGSVTQDATEETEEEEEQEQGDEAGPSERKRSSRKKGGKGGKKGSKKSAAAASKVEIPDPYNSTSEEVCAAIGLTDVEFDYDEEEFQGISNLKTFSSIIKPQILEANPGTNVSKMYPMFQVKYKEYQDHMAAQGKPVQKQARGSKTPAVSTPVIPPRSAPTKTRSARRKRRDSDAPDSDQEFEAFIKQQEQLEDDLVKDKEDARIKRAAEREEKKKGALEAARAAKKAKLEKGEEAENNDYCEECKQDGELLLCDTCPRAYHTVCIDENMEEPPEGDWSCAHCIEHGPEVVKEEPAKQNDEFC... | null | null | chromatin remodeling [GO:0006338]; embryonic digestive tract morphogenesis [GO:0048557]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vulval development [GO:0040027] | chromatin [GO:0000785]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; RNA polymerase II transcription repressor complex [GO:0090571] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcri... | PF08074;PF06461;PF08073;PF00385;PF06465;PF00271;PF00628;PF00176; | 2.40.50.40;1.10.10.60;3.40.50.300;3.40.50.10810;3.30.40.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076750, ECO:0000269|PubMed:17466968}. | null | null | null | null | null | FUNCTION: Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate (PubMed:11076750, PubMed:21060680). This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regul... | Caenorhabditis elegans |
G5EBZ8 | ARK1_CAEEL | MREEPTAGTADATLNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTSNSVANQDDNDHHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEM... | 2.7.10.2; 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q07912}; | embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of vulval development [GO:0040027]; phosphorylation [GO:0016310] | null | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | PF07714;PF07653; | 2.30.30.40;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000250|UniProtKB:Q07912}; CAT... | null | null | null | null | FUNCTION: Probable tyrosine protein kinase which plays a role in vulva development, probably by acting as a negative regulator of the let-23/EGFR and let-60/ras pathway. Involved in the negative regulation of germline development (PubMed:14657502). {ECO:0000269|PubMed:10949028, ECO:0000269|PubMed:14657502}. | Caenorhabditis elegans |
G5EC23 | HCF1_CAEEL | MDEDVGLEATNYSRGDESRSEEQEKNVVRWRIVQQSTGPNPKPRHGHRAVVLKELIVIFGGGNEGMIDELHAYNTQKREWTAPQCCGDVPTPAAAFGAISLGNKIYRFGGMTEYGKYTNDLYELQSTRWEWRRLNPRVHSNGHLPCPRIGHSFVVSQKSQKAYVFGGLSNDLNDPKRNVPHYLDDLYVINLSGPQHLIWEKLNATGPGPISRESHTAVIYEKDSISRMVVYGGMNGVRLGDLWYLNLNTLHWTEIKFDDPRTGIPPMPRSLHSSVLIGDKMFVYGGWVPLLEHASTEQQTEKEWKCTSSLGCWNITEDRW... | null | null | chromatin remodeling [GO:0006338]; dauer exit [GO:0043054]; defense response to other organism [GO:0098542]; determination of adult lifespan [GO:0008340]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of t... | histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714] | PF13415;PF13418;PF13854; | 6.10.250.2590;2.60.40.10;2.120.10.80; | null | PTM: Phosphorylated at multiple serine residues (PubMed:11341844). Phosphorylation is developmentally regulated, occurring in embryos but not L1 larvae (PubMed:11341844). Phosphorylation may be cell-cycle-regulated (PubMed:11341844). {ECO:0000269|PubMed:11341844}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14629117, ECO:0000269|PubMed:18043729, ECO:0000269|PubMed:18828672}. Note=Localizes to nucleus, except for nucleolus. {ECO:0000269|PubMed:14629117}. | null | null | null | null | null | FUNCTION: Transcriptional coregulator (PubMed:18828672). Involved in control of the cell cycle and in modulating mitotic histone phosphorylation (PubMed:18043729). Plays a role in modulating lifespan by regulating the transcriptional activity of daf-16/Forkhead box protein O, in concert with protein deacetylase sir-2.1... | Caenorhabditis elegans |
G5EC24 | PTP2_CAEEL | MPRLALRQYNFYYRVNGEKAEELLKEYGEDGDFLLRYSESNPQNFSISVRVAEDKILHIKVTKYESDMLSIFEDERTTPNQFGSITELAEFYMEFPEKLREKNGLFLELKKPVYVPYHLEACAEEQRRTQLYRWWHGNLPASSANKLLQTEKNGTYLLRASQHIPGALVISAKTEGQVVHLTIYQDPSTGRFNIDGDRTKFQSAWLLIDSYSKNPIVEKGEASRVLYLEEPLFNTFIEADLFVDRFEIIRRPINPRESMEKTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGS... | 3.1.3.48 | null | cell differentiation [GO:0030154]; dephosphorylation [GO:0016311]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; muscle organ development [GO:0007517]; nematode larval development [GO:0002119]; oogenesis [GO:0048477]; positive regulation of epidermal growth factor receptor signaling p... | cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410] | non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphotyrosine residue binding [GO:0001784] | PF00017;PF00102; | 3.90.190.10;3.30.505.10; | Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PIRNR:PIRNR000929, ECO:0000269|PubMed:20380830}. Note=Localizes to vesicle-like structures. {ECO:0000269|PubMed:20380830}. | CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PIRNR:PIRNR000929}; | null | null | null | null | FUNCTION: Involved in embryonic and larval development (PubMed:20380830, PubMed:9472025). Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP) (PubMed:20380830, PubMed:9472025). During the formation of neuromuscular junctions at the larval stage, n... | Caenorhabditis elegans |
G5EC32 | SRBS1_CAEEL | MMHHPHPFGSNLANSSEPQQPSGQYLNPAADAYNFDTFEDSDKFSPKGNVAALRNVIHGQLDMKTPTGNSSRYQKPAPPPVDSTPSWAKNVKVYEPNGYVDPHLNKHNMGRVLDGPVNPNKYFQGVPPASYSQVKHNESKPPVPPSTKPPHSAAQALQAQVLQSSKAPSQPQQSQKTSYRIPYDVALDPRHHLGEFDIDDSASIISSCISTFGESSEIAGFSAAAEQRHLYEQYRKKLMEEKNELKEGSETPCVSLSEKVMTSSTENLKNGNNQQNQQPEPQPPSSSIFNSELTPFGHVAPVAKQFEPTNFPPFSPEKES... | null | null | maintenance of mitochondrion location [GO:0051659]; sarcomere organization [GO:0045214] | adherens junction [GO:0005912]; dense body [GO:0097433]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] | null | PF14604; | 2.30.30.40; | null | null | SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:28978740}. Cell membrane {ECO:0000269|PubMed:28978740}. Cell junction, focal adhesion {ECO:0000269|PubMed:28978740}. Note=Localizes to adhesion plaques and dense bodies between myocytes (PubMed:28978740). Co-localizes with deb-1 and atn-1 at den... | null | null | null | null | null | FUNCTION: Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes. {ECO:0000269|PubMed:28978740}. | Caenorhabditis elegans |
G5EC36 | LIM7_CAEEL | MNICMRNGYEQFSLTSPGTSDLEIGGSFWKDEPDTKYLCLDSPVEQRQHQPPMAVCAGCRLEISDRYFLRVNPNLEFHAQCLKCVQCSRPLDENQTAFVKNGQTYCRDDYRRLFTTRCSRCHGDFDKTDLVMRAGPQNVFHLNCFACVACEKRLQTGEEFQIKNNSLYCRSDCRGLDNPDTSASVPDYSKLNNNNNNDNNNSSSNFDEDEWDEERSTLTSLDNNTSSPLGSPKSDGVRTPLFGHHNSGSGGSTSSCGKKKKDKQATRVRTVLNENQLKILRDCYSINSRPDATLKERLVEMTGLSARVIRVWFQNKRCKD... | null | null | axonogenesis [GO:0007409]; body morphogenesis [GO:0010171]; gonad morphogenesis [GO:0035262]; head morphogenesis [GO:0060323]; locomotion [GO:0040011]; nematode larval development [GO:0002119]; neuron fate specification [GO:0048665]; pharynx development [GO:0060465]; positive regulation of transcription by RNA polymera... | nucleus [GO:0005634] | cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872] | PF00046;PF00412; | 2.10.110.10;1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682}. | null | null | null | null | null | FUNCTION: Probable DNA-binding transcriptional activator. {ECO:0000250|UniProtKB:P61372}. | Caenorhabditis elegans |
G5EC37 | SEPA1_CAEEL | MTPLSALTSNPAPSPPPKFALGKCPATAIHVVSVLRPNRQRFCYEKTDAGDLIPHKCLICQPILTEKHISPYYAVYSDLLEDFVLFGYNTMTGKMEQFIYAFKTDCFVEVNRPEIKYNPAFLVKGNVVVALNGPEGELVVIERDCRGLLSKESTSYGQFRTLPTAALRTLTLQDLERDRWDRAANSDEVKISSGNESFDRLYAEYQKNLPRFQVRQCLHLNKEFLCVYSKTSGDYTRLEYIDETGDFQKISCTLCTCEVTESNLIPLYVERNASELVIHVHNTENNQIEQYIYDVRTFGFVQVKRNLVYDPKKITSGLNL... | null | null | autophagy [GO:0006914]; regulation of DNA-templated transcription [GO:0006355] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | protein self-association [GO:0043621]; protein-macromolecule adaptor activity [GO:0030674]; transcription coregulator activity [GO:0003712] | PF02172; | 1.10.246.20; | null | PTM: Degraded by autophagy. {ECO:0000269|PubMed:19167332}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00311}. Cytoplasm {ECO:0000269|PubMed:19167332, ECO:0000269|PubMed:19372764, ECO:0000269|PubMed:21802374, ECO:0000269|PubMed:24140420}. Cytoplasmic granule {ECO:0000305|PubMed:19167332}. Note=Diffuse cytoplasmic localization, but also localized to cytoplasmi... | null | null | null | null | null | FUNCTION: Adapter protein that connects P-granules in somatic cells with the autophagic machinery (PubMed:19167332, PubMed:19372764, PubMed:19377305, PubMed:24140420). Association with other adapters such as epg-2 and P-granule components such as pgl-3 is required for the accumulation and degradation of P-granules by a... | Caenorhabditis elegans |
G5EC44 | MRT2_CAEEL | MMELETGQCTIMELKKENVKELAQVFKTVAFKDTGTWHASEAGMKITVDDGSYQLASVFINPAFFSSFKVREEIVSMKISIKSISEFLSISENSSSSVKVSYPGMFQPVKMLVEDADGWVARGNFTTTLADQELDFEFDDAGVLATYLLKTQVLKEIIKDFDDTSRTVRIQFTKNSLCFTTFGDVGETTVSIPSRSLQMESVKCLEEVEFSYLLSLIQRMTTAFILATKLILRVDERGVLSCQFSIDHGEGNASYIEFLTVPADEEE | 3.1.11.2 | null | DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004] | checkpoint clamp complex [GO:0030896]; nucleus [GO:0005634] | damaged DNA binding [GO:0003684]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311] | PF02144; | 3.70.10.10; | Rad1 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence={ECO:0000250|UniProtKB:O60671}; | null | null | null | null | FUNCTION: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:12445383, PubMed:16951081). Promotes DNA double strand break-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability (PubMed:10646593, PubMed:10882129, PubMed:169510... | Caenorhabditis elegans |
G5EC86 | MOE1_CAEEL | MNVNGENNEKIDEHHLESSLAGVPTLPVSPLDHAKDLSQTNPNAQIGDLVTQTANLIAIKKQLLEDIAFNQHIQSMQVRAIQSFPQNNQVAPPFQQFDPRRRGLARMQKPESYKTVICQAWLESKTCSFADNCRFAHGEEELRPTFVEPLQNNKYKTKLCDKYTTTGLCPYGKRCLFIHPDHGPNAYIRADKLLEVSQRHALADIRDQMEQHIMTNGRIAAPPLSAIQHPLEMFARPSTPDEPAAKLPLGPTPVSTRGPRYELPTKELHDAEGAMTYPPSRWPLDPSMFALDAWNMAHRPASPLDSMVLGSAPNAGSFGM... | null | null | asymmetric protein localization involved in cell fate determination [GO:0045167]; endodermal digestive tract morphogenesis [GO:0061031]; establishment of chromosome localization [GO:0051303]; meiotic nuclear membrane disassembly [GO:0051078]; negative regulation of endodermal cell fate specification [GO:0042664]; negat... | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; messenger ribonucleoprotein complex [GO:1990124]; nucleus [GO:0005634]; P granule [GO:0043186] | metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900] | PF00642; | 4.10.1000.10; | null | PTM: Phosphorylation by mbk-2 and by gsk-3 are required for its rapid degradation following meiosis II. {ECO:0000269|PubMed:16289132, ECO:0000269|PubMed:16338136, ECO:0000269|PubMed:16343905}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11702779, ECO:0000269|PubMed:12296824, ECO:0000269|PubMed:12781695, ECO:0000269|PubMed:16289132, ECO:0000269|PubMed:16611242, ECO:0000269|PubMed:18854162}. Cytoplasmic granule {ECO:0000269|PubMed:12296824, ECO:0000269|PubMed:12781695, ECO:0000269|PubMed:16611242, ECO:... | null | null | null | null | null | FUNCTION: Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18417623, PubMed:18854162, PubMed:19786575, PubMed:20826530, PubMed:24014033). Acts as a ribonucleoprotein particle component that may exert part of its func... | Caenorhabditis elegans |
G5EC89 | CEH17_CAEEL | MMMEYGGYFSSSAVAQQSGDVPTTAPSAVTNSFFYTPQSHNIYHQYATPYLQSGRALTTAHNTSSSSAGNSTSSSSSSSNYRNTTHDSLQAFFNTGLQYQLYQKSQLIGSDTIQRTSSNVLNGLPRSSLVGALCSTGGAPLNPAERRKQRRIRTTFTSGQLKELERSFCETHYPDIYTREEIAMRIDLTEARVQVWFQNRRAKYRKQEKIRRVKDEEEDPLKKEPGQISLEEIIDQI | null | null | axon guidance [GO:0007411]; neuron development [GO:0048666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon extension [GO:0030516]; regulation of transcription by RNA polymerase II [GO:0006357] | nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF12413;PF00046; | 1.10.10.60; | Paired homeobox family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:10887091}. | null | null | null | null | null | FUNCTION: Probable transcription factor involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA (PubMed:20501595). Regulates its own expression and also that of homeodomain ceh-14, together forming an autoregula... | Caenorhabditis elegans |
G5ECB2 | GABR2_CAEEL | MSRWLSLLLFAVQAVGGYEAGEELSCKRRHGGIPLPLGVFTVQKEGFPDALPAIRTALSHVHSRSCILQGYRLEMIVKDTHCKTSQGMKALFDLIASRPRPVAILGGQCTEVNEPIAMALKYWQIVQLSYAETHAKFASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQNDQPRYALPHEALTTRLEHGFGVKIVHTAGVNWEQIETVGGELDELKERDVRIILVDVDEEMAATVLCAGYHRGMYGDNYVWILPGYHSDKWLNQTHDNCTVEEMREAAKNHFSVEFALTRRDVDTKIVGNTRAGDVWNE... | null | null | G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; regulation of locomotion [GO:0040012]; response to xenobiotic stimulus [GO:0009410] | G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039] | G protein-coupled GABA receptor activity [GO:0004965] | PF00003;PF01094; | 3.40.50.2300; | G-protein coupled receptor 3 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75899}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signali... | Caenorhabditis elegans |
G5ECD6 | CHS1_CAEEL | MNDGENYWNAFRSHKRSATDGPTLSPWMVTVLQATKLLLFALCNIVLTLGSVFSKLIVLIMATNIVPRAHLIGKFARKCTKAAVRRTSTTTAGIYLSLLLIQCFPDTINLIRSGIDMWKGQCGQLVKSVVVLESLRAIGLAVLSFHVFPQLDLARCLVLSACFPLVAVLQRSLVAMVSAARTGRSFRNRLGRCFVAIPHVIMFLVLMSSCYVWALFDNKFTAIIALPIGVICTSAGFWESWIDTTHSGTSFDELYRLKYAVRKMNTTTKLIVSLMRIVCTVSVLVSAVYINDHKKLNSSHFVKAFFSFSTRQPHTRLLLL... | 2.4.1.16 | null | cell wall chitin biosynthetic process [GO:0006038]; chitin biosynthetic process [GO:0006031]; eggshell formation [GO:0030703]; positive regulation of protein localization to cell cortex [GO:1904778] | cell cortex [GO:0005938]; cell periphery [GO:0071944]; cell septum [GO:0030428]; plasma membrane [GO:0005886] | chitin synthase activity [GO:0004100] | PF03142; | null | Chitin synthase family, Class IV subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17869112, ECO:0000269|PubMed:20971008}; Multi-pass membrane protein {ECO:0000255}. Note=egg-1, egg-2 and egg-3 maintain the homogenous distribution of chs-1 at the unfertilized oocyte cell membrane, thus ensuring the formation of a continuous and cohesive eggshell... | CATALYTIC ACTIVITY: Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595, ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223; EC=2.4.1.16; Evi... | null | null | null | null | FUNCTION: Essential for the embryonic synthesis of chitin, a component of the eggshell. {ECO:0000269|PubMed:16098962, ECO:0000269|PubMed:20971008}. | Caenorhabditis elegans |
G5ECD9 | AEX2_CAEEL | MNSTDIIANVTKPFVENLTLGETAFYISCGIVGTVFNALVLWIALTYINTEDKPRQIIVINMTVADLLMCIVYMKTRPWLSHFNLWLCHPYYVIIWTCQMCSCLNLVWLNVDKLIYIQFPLHYYQIVNRKRLLWITAATWGGLYAMNIALVTFLKITRGSCLGVSLNPYVYLLSPIFYVVMILTSFSLSALIYCIAHNLTHMEERQRSKLFRRLFFLFSSTLWTFFTCLPYRLLYLFSIFCGETCQINNYYKTATNLFFRLLIVGIMINPVITIWTQRIYRLRLMRMFGRLRENSSTEVLMVSNRRASERPPEHTPLRCD... | null | null | lipid transport involved in lipid storage [GO:0010877]; neuropeptide signaling pathway [GO:0007218]; positive regulation of defecation [GO:2000294]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of triglyceride transport [GO:1905885]; regulation of defecation [GO:2000292] | cilium [GO:0005929]; plasma membrane [GO:0005886] | neuropeptide receptor activity [GO:0008188] | PF00001; | 1.20.1070.10; | G-protein coupled receptor 1 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23583549}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium {ECO:0000269|PubMed:18852466}. | null | null | null | null | null | FUNCTION: G-protein coupled receptor for the nlp-40 neuropeptide (PubMed:23583549). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23583549). Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 sec... | Caenorhabditis elegans |
G5ECE3 | LAM3_CAEEL | MRLWLGLLAVSNIALGGWNTSEDASIWENYVEDSNYHEFISSESERGLFPNIFNLATNSLITATDTCGQYTAEEYCKLVEHVLLRKTTNTQSPQCDICDANNVHKRHPIEYAIDGTRRWWQSPSLANGLRFEKVNITIDLRQEYQVAYIILKMGNSPRPGTWVLEKSLDGEYYEPWQYYAMQDAECMRQFGIPATTGVPRFQKEDEVHCTSEYSKITPLENGEIHTSLVNGRPGAENTSLELQKFTRARFVRLRLISPRTLNADLMIINKKSDSLDKSVTMRYFYSISDISIGGQCICYGHAESCPSDPVTGQFKCECRH... | null | null | animal organ morphogenesis [GO:0009887]; axonogenesis [GO:0007409]; tissue development [GO:0009888] | basement membrane [GO:0005604]; extracellular region [GO:0005576] | extracellular matrix structural constituent [GO:0005201] | PF00052;PF00053;PF00054;PF02210;PF00055; | 2.60.120.200;2.60.120.260;2.10.25.10;2.170.300.10; | null | null | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12783803}. Secreted, extracellular space {ECO:0000269|PubMed:12783803}. Secreted {ECO:0000269|PubMed:12783803}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:12783803}. Note=May be ... | null | null | null | null | null | FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required to assemble a stable basement membrane and for organizi... | Caenorhabditis elegans |
G5ECG0 | TACC1_CAEEL | MSLNTTFTKEDGTEVVIPFNGSQNGHPENEEPEVEEAAEPSSSVETLCGATRGDIIVMKHTTKALTELIERLLHSDEFEVRRCSNGQIISQGRCNGTTPGNGIGGGGASSEELEKALKDRDAARAEADKLHANYATLFASFNTVREAANDIRGEYEDARDKLKLAAAEVDEWQAKFLAVKDNANSELERASVEYDDLLRSHDENTKGLRLRVKRQEIELSSKNDEIKVLTNRVSELSQICDQLLNDVDVSDGMSVISTDA | null | null | astral microtubule organization [GO:0030953]; cell division [GO:0051301]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic cell cycle [GO:0051321]; microtubule-based process [GO:0007017]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; negative regulation of m... | axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle microtubule [GO:1990498]; perikaryon [GO:0043204]; spindle [GO:0005819]; spindle pole [GO:0000922] | protein domain specific binding [GO:0019904] | PF05010; | null | TACC family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:12956950, ECO:0000269|PubMed:12956951}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12956950, ECO:0000269|PubMed:12956951, ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:17666432}. Cytoplasm {ECO:... | null | null | null | null | null | FUNCTION: Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length (PubMed:12956950, PubMed:12956951, PubMed:16054029). Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis (PubMed:12956950, PubMed:12956951). In co... | Caenorhabditis elegans |
G5ECG2 | FOS1_CAEEL | MFEQPSSTTNTTTSSGSGSDSNHYFELGPRNPINQAHPTSVIVPPRQHHHQIHQQQTDNSPLTPCTPYYPSNAYGLPLFFGTDFLQFQPSDIPSPLTPNISSPLTPHPFGPIPAIPTNQIYNRTFTDFYSTAASSPMVQYSTVKKSSAGRKPKEEDNMEDDDDDKRLKRRQRNKEAAARCRQRRIDLMKELQDQVNDFKNSNDKKMAECNNIRNKLNSLKNYLETHDCKLSREERTHEINRLIIPPSTVPPSQPYLQHSLRVHPPRADSVPYSIRSGHSSSSSEQHSPVEDYKPSIDQLLLPPISCIQNIKDRNINSMPP... | null | null | anatomical structure morphogenesis [GO:0009653]; basement membrane disassembly [GO:0034769]; cell fate specification [GO:0001708]; determination of adult lifespan [GO:0008340]; innate immune response [GO:0045087]; negative regulation of stress response to copper ion [GO:1903854]; negative regulation of transcription by... | nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding ... | PF00170; | 1.20.5.170; | BZIP family, Fos subfamily | PTM: May be phosphorylated by kgb-1. Phosphorylation at Thr-440 increases sensitivity to heavy metal stress. Phosphorylation inhibits homodimer formation, and promotes association with target promoters. {ECO:0000269|PubMed:23437011}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15960981}. | null | null | null | null | null | FUNCTION: Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3' (PubMed:23437011). {ECO:0000269|PubMed:23437011}.; FUNCTION: [Isoform a]: Plays a role the development of the reproductive system, controlling events including anchor cell (AC) fusion and invas... | Caenorhabditis elegans |
G5ECG7 | MTP_CAEEL | MFSSRIWLLLAVTVGVCLAVPDLDEIKKNLRKHGPDYYKNQPKMNENTVRLLKVDYWFRTESMIYDDIDNKEKDPSTVIAGNFSFETLHHDVEGGMLGRFTLTQCNTDNCGNPSPIYIAFRQGGNNAEHILKASDESDATWNFLYAIVNTIYTPAEYGEGDEQTVDTIYGRCFVNFGRPEDKRFRRIIEKCDLGYGTNFTKFEGIESVQYDQDVWYTQNTKVDADIIMVDAIEMLAFKSPLHEKYGFTLESRTHVEITNRTRVFVTSYCNDTVPSAKCAEQAFGAVRVGGKLYEHVKIAQEQSNKLTKLIGTYRRHLQDM... | null | null | endoplasmic reticulum unfolded protein response [GO:0030968]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; plasma lipoprotein particle assembly [GO:0034377] | basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794] | lipid binding [GO:0008289]; phospholipid transporter activity [GO:0005548] | PF19444; | null | null | null | SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:17924655}. | null | null | null | null | null | FUNCTION: Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Does not catalyze transport of triglycerides (PubMed:17924655). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:14657502, PubMed:17924655). Require... | Caenorhabditis elegans |
G5ECH5 | PP4R1_CAEEL | MIKSQFATLIRVLIDFQKFWVFLSIFCTFLVVFKFDNLMFQKVRRVFQQNRKNSESIQPKLSTVSGSNSGEGMDKRNTGFSNLQQLGGAIFIDDAEDEPPRVKSSEDSRPAPHWLDSPRDSTTLPDIIASTYSDFIDEAEYATKQMLAILETLNPIEEYIELFESSFKAIEVRLPFDVILNDEKKPDWDAIRRKLIMGSLTVNTTSEKPGITTNQMTAIFDAIPFLFDAVACNPELYEYQNTLSMIVMIAMTGNSMIRRQSINAVQALMERNMLDQDFMRDGVVPGLFNIYQSGVGAFQSNDLRMECVQALCQVISYDAI... | null | null | embryo development ending in birth or egg hatching [GO:0009792]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of meiotic spindle elongation [GO:1902120]; polar body extrusion after meiotic divisions [GO:0040038]; regulation of mitotic spindle elongation [GO:0032888] | cytoplasm [GO:0005737] | protein domain specific binding [GO:0019904]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] | null | 1.25.10.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23918937}. Note=Localizes to the cytoplasm during meiosis and mitosis. {ECO:0000269|PubMed:23918937}. | null | null | null | null | null | FUNCTION: Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the k... | Caenorhabditis elegans |
G5ECH7 | CDK5_CAEEL | MLNYDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRHAYFADTSDV | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:20510931}; Note=Binds 2 Mg(2+) ions. {ECO:0000250|UniProtKB:P24941}; | anterograde neuronal dense core vesicle transport [GO:1990048]; axonogenesis [GO:0007409]; cell cycle [GO:0007049]; cell division [GO:0051301]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; negative regulation of dense core granule transport... | axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; protein kinase 5 complex [GO:0016533]; synapse [GO:0045202] | ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20510931}. Cell projection, dendrite {ECO:0000269|PubMed:20510931}. Note=Localizes predominantly to presynaptic sites and in dendrites as faint puncta. {ECO:0000269|PubMed:20510931}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:20510931}; CATALYTIC... | null | null | null | null | FUNCTION: Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1... | Caenorhabditis elegans |
G5ECJ0 | GBR1_CAEEL | MSASILILATCHQVLADFNSYVVPQPHAQRDHRQDISQHYDYLMEENDEPLGRGAAPSKYRSSHGQAQHRPEMTESENFAQPNTESVFSSGGVDSYGETRDFLQFLRRIQYDHRQVPENEKGEATYVEVSVVVSNIRAVSEVTMDYALELFYRESWRDPRLQYDRKLFKNKTELALHESYTNFLWFPDTFVPNAIASKNPQRNSISHRSLLRLDETGKLLYSRRISLVCECTMDLTLFPFDKQLCKLGIESYGYTADHVVYKWSKGARTALELKKIRLPDFTIQEAYVTSQMESYATGNYSRLYVCFVFSRSSGFCFLQL... | null | null | chloride transmembrane transport [GO:1902476]; defecation [GO:0030421]; lipid transport involved in lipid storage [GO:0010877]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of muscle contraction [GO:0045933]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] | GABA-A receptor complex [GO:1902711]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] | chloride channel activity [GO:0005254]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; GABA receptor activity [GO:0016917]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594] | PF02931;PF02932; | 2.70.170.10;1.20.58.390; | Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily | null | SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:14555952}. Cell membrane {ECO:0000250|UniProtKB:P18505}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18505}. | null | null | null | null | null | FUNCTION: GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+) (PubMed:14555952). Has negligible divalent cation permeability (PubMed:14555952). Does not act as a chloride channel (PubMed:14555952). Mediates enteric muscle contractions required for defecat... | Caenorhabditis elegans |
G5ECJ6 | CSK1_CAEEL | MSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNTLNANRDLLSPGNDVIVTRTVSPSFYSHGMPARDNVFRKDDHVRILGNTTDPAWYRARNANQEEGLVHADCVVRINGQAYDNGIVRMRASGCDVAPGAASTTSSTSSHHSTAANHQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGML... | 2.7.10.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P41240}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P41240}; | embryo development ending in birth or egg hatching [GO:0009792]; larval feeding behavior [GO:0030536]; muscle cell development [GO:0055001]; nematode larval development [GO:0002119]; nematode pharyngeal pumping [GO:0043050]; phosphorylation [GO:0016310] | cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] | PF07714;PF00017; | 3.30.505.10;2.30.30.40;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, CSK subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000269|PubMed:12527374}; | null | null | null | null | FUNCTION: Non-receptor tyrosine-protein kinase which plays a role in pharynx function by regulating pumping and the orientation of pharyngeal muscle fibers, independently of src-1 and src-2 (PubMed:19210548). May phosphorylate and thereby negatively regulate src-1 and src-2 activities (PubMed:12527374). {ECO:0000269|Pu... | Caenorhabditis elegans |
G5ECK3 | MAB23_CAEEL | MPKEQYMCQLCANHGIFNQPKKGHKQKCPYRTCPCSLCALNTKRRALDQIERQLKHTNEPMTGQTATSMASPTPECPLSPTTPKMTPHTPTSGKDTFRNSISSSNMAFTVQLPATITKKELKLLRRDDTPLQNSLERPFPRSIDEAIETIKKEKMSSIFHSAEMLAVGESATSLI | null | null | negative regulation of gene expression [GO:0010629]; neuron fate determination [GO:0048664]; regulation of male mating behavior [GO:1902435]; regulation of nematode male tail tip morphogenesis [GO:0110037]; sex differentiation [GO:0007548] | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00751; | 4.10.1040.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}. | null | null | null | null | null | FUNCTION: Probable transcription factor that plays a role in the development of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays, by negatively regulating the activity of the transcription factor ast-1 (PubMed:12231628, PubMed:22069471). Involved in male mating behavior... | Caenorhabditis elegans |
G5ECL2 | SYNJ_CAEEL | MSVRGIRIWRRNDARFQPSILVEKNGLDGSLLFQGGAIATLDSDSTDVERRSYQKIVDAYGILGVLAITKDEAVLVAVTGVLSVGQLYGADILKITNVEFISLRTFGSVENVDSRIIDLQRLLSSQMFYFSSLQSYDLTRSAQHRDSHDCSDARFFWNRSLHFSFQRYGIDTDNWLLKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLFDEKECSLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYGEFAIVNLLGRKEGERVLGDAFKTQHKSSHF... | 3.1.3.36 | null | acetylcholine transport [GO:0015870]; cytoskeleton organization [GO:0007010]; endosome organization [GO:0007032]; gamma-aminobutyric acid transport [GO:0015812]; Golgi vesicle uncoating [GO:0048212]; locomotion [GO:0040011]; muscle contraction [GO:0006936]; necroptotic process [GO:0070266]; phosphatidylinositol dephosp... | membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; synaptic vesicle [GO:0008021] | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124] | PF08952;PF02383; | 3.30.70.330;3.60.10.10; | Synaptojanin family; Inositol 1,4,5-trisphosphate 5-phosphatase family | null | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:14622579, ECO:0000269|PubMed:21029864}. Synapse {ECO:0000269|PubMed:14622579, ECO:0000269|PubMed:18094048, ECO:0000269|PubMed:21029864, ECO:0000269|PubMed:25918845}. Note=Localizes to puncta at neuromuscular junctions in ... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence={ECO:0000250|UniP... | null | null | null | null | FUNCTION: Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis. {ECO:0000269|PubMed:10931870, ECO:0000269|PubMed:18094048, ECO:0000269|PubMed:25918845}. | Caenorhabditis elegans |
G5ECL4 | BRAM2_CAEEL | MSSERRKDNPLRFALILHLLAVLVQGDIQPRFSCYNHYLAGIRTSSVLPISGHSSAPSNVKCIFENDVAFTEIHSALENSYQVMGKKSVNFQVLDLFHLRELVRRSHCTQTLTVTWKNVPEAGKGGLKVVSLLNETTRIEYSGDERQDFLFDETFAGVRHLIPDEDDNESNPTVTTTRLLCKHIPQPECLVRGKFEVDLEANLEWSYAFSFKTDITNQTLFTLRCGDTTSEVRLENDFFIRADGNAPVAVTHLSDATWHTAIVKHNQPDSHFLKIDDFPEIELGKSISDDTDKTITLSISVNGNIQLIDPTDTNDDCMYS... | null | null | nervous system development [GO:0007399] | axon [GO:0030424]; plasma membrane [GO:0005886] | null | null | 2.60.120.200; | Neurexin family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14551437}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:28901288}. | null | null | null | null | null | FUNCTION: Maintains the normal guidance and termination of axonal branches of VC motorneurons (PubMed:14551437). By associating with cell adhesion protein casy-1, mediates axonal interactions to establish synaptic connections between the male-specific sensory neuron HOA and the AVG interneuron (PubMed:28901288). Plays ... | Caenorhabditis elegans |
G5ECM9 | CPI2_CAEEL | MKAILVFALIAISIISVNAGMMTGGSVEQDASQKEYSDKAWKAVKGINDQASNNGPYYYAPIKVTKASTQVVAGISTKLEVLVGESNCKKGELQAHEITSSNCQIKDGGSRALYQVTIWEKPWENFEQFTVEKIRDVTADEQF | null | null | positive regulation of vitellogenesis [GO:1903188]; regulation of oocyte development [GO:0060281]; regulation of protein processing [GO:0070613] | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982]; yolk granule [GO:0042718] | cysteine-type endopeptidase inhibitor activity [GO:0004869] | PF00031; | 3.10.450.10; | Cystatin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16857685}. Secreted {ECO:0000269|PubMed:16857685}. Cytoplasmic granule {ECO:0000269|PubMed:16857685}. Note=Localizes to the sheath cell cytoplasm surrounding germ cells and oocytes. Localizes to yolk granules in the developing oocyte. {ECO:0000269|PubMed:16857685}. | null | null | null | null | null | FUNCTION: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (PubMed:12704112, PubMed:15664654). Does not inhibit asparaginyl endopeptidase (PubMed:15664654). Required for the uptake and/or processing of yolk proteins during the development of oocytes, probably by regulating the catalytic act... | Caenorhabditis elegans |
G5ECN5 | STRD1_CAEEL | MADTTILDTTCSSTLAANVEFSHATDSAIGISLKNATITEAEGVPNLKETGYDCVRYMGTCNGGQIYLGRERKKLKDYVAIKKFAIDDVDDYAAIAKESSNLRLMHHPNIIELCECFVYERSIYQITPAMNLGSLFDIVFEYMKWGINEKSAAAITRQLLDALSYLHQRRYIHRDLKPKHILIDSSGNVKLSGFRFMIELNHHLDCVFEFDAHLQNQLYYLAPEVLAQNIHGYTSKSDIYMLGISICEAINGVMPFGELEPLEMLHRKLNGQVPRPVDMISLKDDQKMGLDISHRPQEHLTRRFSKEMHEFIANCLDYDP... | null | null | asymmetric neuroblast division [GO:0055059]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of dauer [GO:0043055]; negative regulation of apoptotic process involved in development [GO:1904746]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; protein localization to synap... | axon [GO:0030424]; cell body [GO:0044297]; cell cortex [GO:0005938]; dendrite [GO:0030425]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; synapse [GO:0045202] | ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] | PF00069; | 1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily | null | SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:20023164}. Nucleus {ECO:0000269|PubMed:20023164}. Cell projection, dendrite {ECO:0000269|PubMed:20023164}. Cell projection, axon {ECO:0000269|PubMed:20023164}. Synapse {ECO:0000269|PubMed:20023164}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20110331}. Cytoplasm {ECO... | null | null | null | null | null | FUNCTION: Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses (PubMed:20023164). Required to establis... | Caenorhabditis elegans |
G5ECN9 | NEC2_CAEEL | MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGE... | 3.4.21.94 | null | arg-arg specific dibasic protein processing [GO:0090474]; determination of adult lifespan [GO:0008340]; dibasic protein processing [GO:0090472]; insulin processing [GO:0030070]; larval feeding behavior [GO:0030536]; negative regulation of dauer entry [GO:1905910]; negative regulation of dense core granule transport [GO... | axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] | FBXO family protein binding [GO:0098770]; serine-type endopeptidase activity [GO:0004252] | PF01483;PF00082;PF16470; | 2.60.120.260;3.30.70.850;3.40.50.200; | Peptidase S8 family, Furin subfamily | PTM: Ubiquitinated. {ECO:0000269|PubMed:23665919}. | SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:11717360, ECO:0000269|PubMed:12657671}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000303|PubMed:11717360}. Secreted {ECO:0000303|PubMed:24671950}. | CATALYTIC ACTIVITY: Reaction=Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.; EC=3.4.21.94; Evidence={ECO:0000303|PubMed:12657671, ECO:0000305|PubMed:15180830, ECO:0000305|PubMed:16945111, ECO:0000305|PubMed:23665919, ECO:0000305|PubMed:24671950}; | null | null | null | null | FUNCTION: Serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:12657671, PubMed:15180830, PubMed:16945111, PubMed:23665919, PubMed:24671950). Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:12657671, PubMed:16945111). Probably by processing flp-1 and... | Caenorhabditis elegans |
G5ECP4 | PIK1_CAEEL | MDDSLGVSEVVMIPFMKREVLQQICAILDTDNTWETIAPYMPGIELRDVEGCKRYSSYNQSPSELLLRIWSSKGYSTTHLYQLFAKTKLIRLMRMMRSQVHEKYHYLENKVTNSTSRVSKQMVQPPGSQSASRLKKTEIKESSPSPAAAAASQLSRSNTDDTLRVAIEGTLPVTYCELLEATNGFAVSNVIGKGGYGTVYKGELKGTGGIVAVKRLHSGNDTSQNGSRERLRQSLTELRTLARFRHDNILPIYAYSLEGSEPCLVYQFMSNGSLEDRLLCRKGSVPLTWIQRKEISIGAGRGLGFLHSFGKTPIIHGDIK... | 2.7.11.1 | null | cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; regulation of response to stimulus [GO:0048583]; Toll signaling pathway [GO:0008063] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00531;PF00069; | 1.10.533.10;1.10.510.10; | Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q05652}; CATALYTI... | null | null | null | null | FUNCTION: Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. {ECO:0000269|PubMed:28099418}. | Caenorhabditis elegans |
G5ECQ2 | FRIZ2_CAEEL | MLLRISVLFLLLGSCGALFGKRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEKSKVGNVTNCAYSCHSPALAESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVAVGFMIRYFVGHEEIACDSMRIKGADDNSGSLCFVVFLLTY... | null | null | canonical Wnt signaling pathway [GO:0060070]; motor neuron migration [GO:0097475]; neuroblast migration [GO:0097402]; neuron migration [GO:0001764]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of motor neuron migration [GO:1905485]; sensory neuron migration [GO:1904937] | plasma membrane [GO:0005886] | G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] | PF01534;PF01392; | 1.10.2000.10;1.20.1070.10; | G-protein coupled receptor Fz/Smo family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Receptor for Wnt proteins (PubMed:19855022, PubMed:20711352). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second... | Caenorhabditis elegans |
G5ECQ3 | SEL5_CAEEL | MPLGLFSSGKAQVLCDEKIPGGKKKEPKQLSENKCKGVTLKLDHTRVTIEKQIAEGGFAIVYVASDRKNNKFALKRQFTKDNEKQLEACCREHSFLKQCIGHKNIVEFVDSYTNCLGNGIWECMLLTEYHQKNVLQLMNERISQNQYLTNDEILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQILSVEKYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPFEESPLAIQSVNYQFPSVPNIPDEIKVLIYMLLDIDVNRRPSIYQTSVLAFEANH... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305}; | actin cortical patch assembly [GO:0000147]; actin filament organization [GO:0007015]; phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of clathrin-dependent endocytosis [GO:2000369] | cytoplasm [GO:0005737] | AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family | null | SUBCELLULAR LOCATION: [Isoform a]: Cytoplasm {ECO:0000269|PubMed:10581273}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000305}; CATALYTIC ACTIVITY: React... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase which may play a role in lin-12-mediated cell-fate decisions. {ECO:0000269|PubMed:10581273}. | Caenorhabditis elegans |
G5ECR9 | UNC55_CAEEL | MQDGSSGAASLGNSSPDATDCVVCGDKSSGKHYGQFSCEGCKSFFKRSIRRSLSYTCRATKNCAIDVQHRNQCQYCRLTKCIRMGMRKEGRRSNETQTAVSAVQRGRLPVTMPSLFPPNMFLRSPFPFMSVPFNPLMTAQFTKPSIKESIFEFAAQTIFATVNWARTSMSNLVKGDQLILLRHSWTPIFIFALAQSNFALNLSTHLTAVTATAASTENGSSSLGSKSEDEEKSEEKPERVFDEPQFQGFQAKIDKIRDFHLDVVESSSLRAVLLFSCDEEALEEKGKIEEIVEKLKSAVDEYCKMNKRSERYHQICECLQ... | null | null | cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] | nucleus [GO:0005634] | nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000255|RuleBase:RU004334}. | null | null | null | null | null | FUNCTION: Transcription factor (PubMed:28056346, PubMed:29033363). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factors unc-3 or irx-1 in subsets of motor neurons (PubMed:22031882, PubMed:28056346). Probably acts by bin... | Caenorhabditis elegans |
G5ECT0 | PBO5_CAEEL | MTRLSILQHLLTFLILSKINATSTTESYFDSSEEAPNVLLNHLNNESEGEELTQINDTQPAFVPGSSKRLTEYLLSRHNLNAPPDGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDPALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSCEINIRHFPLDDQRCAIEIASWAYGQEKIRLHAHTDHSLEHYKRNEEWHLLNLNVSEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGVTAILTMAV... | null | null | defecation [GO:0030421]; lipid transport involved in lipid storage [GO:0010877]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of striated muscle contraction [GO:0045989] | neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] | excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved... | PF02931;PF02932; | 2.70.170.10;1.20.58.390; | Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18191228}; Multi-pass membrane protein {ECO:0000269|PubMed:18191228}. | null | null | null | null | null | FUNCTION: Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle (PubMed:18191228). Probably by regulating the defecation motor program, required for fatty acid uptake by intesti... | Caenorhabditis elegans |
G5ECU1 | SKR1_CAEEL | MADQKKVSEAAKEREIKISSSDNEIFLVPRNVIRLSNTINTLLMDLGLDDEEGTNAEPIPVQNVTASILKKVISWCNHHHSDPISTEDSDNREKRTDDIGSWDVEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWCED | null | null | female sex differentiation [GO:0046660]; mitotic cell cycle [GO:0000278]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic ... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | cullin family protein binding [GO:0097602] | PF01466;PF03931; | null | SKP1 family | null | null | null | null | null | null | null | FUNCTION: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates cell proliferation during embryonic and larval development (PubMed:11864566, PubMed:11864... | Caenorhabditis elegans |
G5ECU7 | JUN_CAEEL | MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKESTAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV | null | null | determination of adult lifespan [GO:0008340]; nitrogen catabolite activation of transcription from RNA polymerase II promoter [GO:0001080]; positive regulation of cellular response to amino acid starvation [GO:1903833]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA splicing [GO:0033120... | nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565] | null | 1.20.5.170; | BZIP family, Jun subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:24178943}. | null | null | null | null | null | FUNCTION: Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3' (PubMed:17942488). Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917). {ECO:0000269|PubMed:17942488, ECO:... | Caenorhabditis elegans |
G5ECW5 | CSP3_CAEEL | MFFGKLGGFAFFLQRAVRCDGFIDNFFDRIPKFFQFMKSKFPSHQTSSSQADLLVSFSTSPGFLSFKDETKDTWYIQELYRVIIENAKDTHLADLLTETNRRVVEKYEADKVVFVCKQAPEFWSRFTKQLFFMSRNDVF | null | null | inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in development [GO:1904746]; positive regulation of apoptotic process involved in development [GO:1904747]; positive reg... | cytoplasm [GO:0005737] | caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; zymogen binding [GO:0035375] | PF00656; | 3.30.70.1470; | Peptidase C14A family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18776901}. | null | null | null | null | null | FUNCTION: Non-catalytic caspase homolog which does not contain the region necessary for caspase activity (PubMed:9857046). Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4-induced ced-3 processing (PubMed:18776901). Has no effect on active ced-3 (PubMed:18776901). Probably by preventing ced... | Caenorhabditis elegans |
G5ECX0 | LPLT2_CAEEL | MAKQLKYPFLIFIISLAQCQVSNQNVNLCQSNICQNGGTCLVASSVPATATCPKNSIYYMGSCYVFDTTLRNWNDAALYCNNMNSATLPLVESAEDQAFFAGYLQAMIPSNPPADMRPPPDGIWTAVRGVNNVTRASWVYYPGSFLVTDTFWAPQEPNIYVNYNDVCVALQSDSFYREWTTALCTILKYTVCKVAPTQIQAKYVAQCSCPNGYGGQTCETQSTTNQQASTQRTCGSNDFQFSCPNDQTITVDFASFGAQESSMCNQASQSREQTCSNVNSLQTVINACQGLQSCEIRNLTSTFSNTPCPVPQEQYLETRM... | null | null | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; self proteolysis [GO:0097264] | plasma membrane [GO:0005886] | carbohydrate binding [GO:0030246]; endopeptidase activity [GO:0004175]; G protein-coupled receptor activity [GO:0004930] | PF00002;PF16489;PF02140;PF01825; | 2.60.120.740;2.60.220.50;4.10.1240.10;3.10.100.10;1.20.1070.10; | G-protein coupled receptor 2 family, LN-TM7 subfamily | PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000255|PROSITE-ProRule:PRU00098}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: May have a role in pharyngeal pumping during feeding. {ECO:0000269|PubMed:17583712}. | Caenorhabditis elegans |
G5ECY0 | DLG1_CAEEL | MSHESSEKAHKAIENVEDYCQTLTRHGNEELRTNLERVITTFKSNLMHSLLDIHDLYEQTLLSERKSDAEKNMEVRRVIERLEGGPHSYNSRPAATTSTSNYNLSSTTPLISDLRDRGGFSYLNGGGLGNGLGNGLGNGLLSSPYNSSSTHYLHERQRQTSHDGTWRETTTRTVDTPSGLERRVVEHTGVIDDHGRKWELENIVLEKGHTGLGFSITGGMDQPTEDGDTSIYVTNIIEGGAALADGRMRKNDIITAVNNTNCENVKHEVAVNALKSSGNVVSLSLKRRKDEAFLPIGGNFGGSTSYLRSGVTPSVSAGNL... | null | null | cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; embryo development ending in birth or egg hatching [GO:0009792]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; zonula adher... | adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:009883... | guanylate kinase activity [GO:0004385] | PF00625;PF09058;PF00595;PF00018; | 2.30.42.10;3.30.63.10;1.10.287.470;3.40.50.300;2.30.30.40; | MAGUK family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11715019, ECO:0000269|PubMed:18411252}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12959}. Apical cell membrane {ECO:0000269|PubMed:11715019}. Cell junction, adherens junction {ECO:0000269|PubMed:11715019, ECO:0000269|PubMed:18411252}. Lateral cell membrane {E... | null | null | null | null | null | FUNCTION: Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical ju... | Caenorhabditis elegans |
G5ECZ4 | DYF2_CAEEL | MSLKVIPCTLTKNQEVFKCVSAQLQYRRGEEEHGSGPIIHRWRPNGHTVAVACANNTVIYYDKKGNVIDALNPTGKLIDIAWDKEGDVLAIAVANTGTIYLWDVNSRNTDTVESGATSSKELPTCLAWSPSTPTLVIGNNAGNIVVYNHRTSRRIAVMGKHQRSVTQITVTPEDYVISCSDDNTLSVTTLEGTTVSTTTTNGEPTNMDYGSVNGKGGSGVTMVSVVIGKKILMLAHYNALDEPVNLQFQEKYGNIHSYRWFNDGYILIGFDRGYIISISAHNNEIGSELVSFLEYRGYLASIAVSTSFNKLLTIGDNMVK... | null | null | chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; non-motile cilium assembly [GO:1905515]; olfactory behavior [GO:0042048]; protein localization [GO:0008104]; protein transport [GO:0015031] | cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; non-motile cilium [GO:0097730] | null | PF15911; | 1.25.40.470;2.130.10.10; | null | null | SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:16957054, ECO:0000269|PubMed:22922713}. | null | null | null | null | null | FUNCTION: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:28479320). Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme (PubMed:16957054, PubMed:229227... | Caenorhabditis elegans |
G5ED14 | PAX5H_CAEEL | MEPIWRNYPYPTYPGHHNFQFDPLLSDGSHTGVNQLGGVFVNGRPLADTVRAQIVEMSQHGTRPCDISRQLKVSHGCVSKILGRYYSTGSVRPGVIGGSKPKVATPRVVECIAGYKRANPTMFAWEIRQKLIEDQICGEENVPSVSSINRIVRNKSFMAQLAAPTSVTSSAARPSSATSHHQRSPPRGVQQHMQQSTSVQQLQQLQLTSAATVNSLMTPPAFAMPGTAYSINGLLGTLPQPSLLDDKFTNLSTQSADMSLVYSTGLVGEHDWTMRTPMVILPQNYCGQL | null | null | apoptotic process [GO:0006915]; cell fate specification [GO:0001708]; embryo development ending in birth or egg hatching [GO:0009792]; nematode larval development [GO:0002119]; nematode male tail tip morphogenesis [GO:0045138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transc... | chromatin [GO:0000785]; nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; se... | PF00292; | 1.10.10.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00381, ECO:0000305|PubMed:11532910, ECO:0000305|PubMed:17021039, ECO:0000305|PubMed:31398431}. Chromosome {ECO:0000269|PubMed:17021039}. | null | null | null | null | null | FUNCTION: Transcription factor (PubMed:17021039). Binds to specific DNA sequence motifs in regulatory elements, for example in the genes encoding transcription factor lin-48, apoptosis regulator ced-9 and neuropeptide-like protein nlp-2 (PubMed:11532910, PubMed:15923112, PubMed:17021039, PubMed:31398431). Specifies cel... | Caenorhabditis elegans |
G5ED29 | ATX2_CAEEL | MSTPTGLPALNGDVLSAINDMIGRVIIINTTDKKRYSGVLGAVSQDFDFGMQCVVEITKENENNLLRTESECRDKMVFHYSDIVDFAYVTQEIKKQHAVSKFVTDRQYHGDTPIEGEELQEWNGGEEDGLGGSIEDDVVVAGGQTAARRSNNHNNGTGWSVNDMFAANEKMNVVSTFKEDLTQYTTVEVVGTDEDRARAERLAREIESNSSSKFMANLENDDDERDLDKITRQEDFENGNGRKRNNNSFNQQQQQRRNPNIAPNGQPVNRRAEGLRGDRRNSGSSSANNSRYGAPAAAQQNYSQNQQQQQGQKGYRRQNE... | null | null | astral microtubule organization [GO:0030953]; chromosome segregation [GO:0007059]; detection of temperature stimulus [GO:0016048]; establishment of mitotic spindle localization [GO:0040001]; female gonad development [GO:0008585]; maintenance of centrosome location [GO:0051661]; negative regulation of centrosome duplica... | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634] | mRNA binding [GO:0003729] | PF14438; | null | Ataxin-2 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15342467, ECO:0000269|PubMed:27457958, ECO:0000269|PubMed:27689799}. Nucleus {ECO:0000269|PubMed:27457958}. Note=Co-localizes with szy-20 and pab-1 in the cytoplasm. {ECO:0000269|PubMed:27689799}. | null | null | null | null | null | FUNCTION: Probable RNA-binding protein that negatively regulates the translation of targets (PubMed:15342467, PubMed:27689799). Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubul... | Caenorhabditis elegans |
G5ED35 | TTR52_CAEEL | MSRFLIYFLPFFIYSGNVLSKTSCLMATGVLKCPTDPEAVKKVHIDLWDEDSLPLESDDLMGRTWSDRNGNFQVTGCASDFGPINTPDPYLYIQHNCPHRDSNATNPIQIDVIPLFLPSIVRLGNVYLDRYLEDY | null | null | aminophospholipid transport [GO:0015917]; apoptotic process involved in development [GO:1902742]; recognition of apoptotic cell [GO:0043654] | cell surface [GO:0009986]; extracellular vesicle [GO:1903561] | phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; scavenger receptor binding [GO:0005124] | PF01060; | 2.60.40.3330; | Nematode transthyretin-like family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20526330, ECO:0000269|PubMed:22713871, ECO:0000269|PubMed:22727702}. Cell surface {ECO:0000269|PubMed:20526330, ECO:0000269|PubMed:22713871, ECO:0000269|PubMed:22727702}. Note=Detected almost exclusively on the surface of apoptotic cells. In some embryos, also observed... | null | null | null | null | null | FUNCTION: Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of ... | Caenorhabditis elegans |
G5ED39 | SEP1_CAEEL | MKITNKSVDKQHIEKLDELRKNVSCTVIGFAEQTAELQQEISELFIAEFGVNGPIDMNSLSKLARITSYYASSEYFQGLAKYQRTACKMFITWQTLRKEAMECRSKDREIFASIPAKLCFFYFYNGELCRAVVCLLDYIDLSDDTLAKEAALRWLMFLGETELIEKKLKTWKMDKSSKDMFSATEFAMNYLKKSEYRVEMLEKLMKLRDKVKSDPTRSFSRYELASYVSWLCSTLSNVPVGSALRECEFPDRVSHIQEAALKSDSLVRNRIPGLASSQFDNSVNASIWPFLDGHQEDSNYYVHIGSTIAWHFEMRRECAL... | 3.4.22.49 | null | cortical granule exocytosis [GO:0060471]; eggshell formation [GO:0030703]; maintenance of meiotic sister chromatid cohesion [GO:0034090]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; meiotic chromosome separation [GO:0051307]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid separation [GO:0... | cell cortex [GO:0005938]; centrosome [GO:0005813]; chromosome [GO:0005694]; cleavage furrow [GO:0032154]; condensed nuclear chromosome [GO:0000794]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; metaphase plate [GO:0070090]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucl... | cysteine-type endopeptidase activity [GO:0004197] | PF03568; | null | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17913784, ECO:0000269|PubMed:23401519}. Chromosome {ECO:0000269|PubMed:17913784, ECO:0000269|PubMed:20116245, ECO:0000269|PubMed:23401519}. Cytoplasmic granule {ECO:0000269|PubMed:17913784, ECO:0000269|PubMed:21878498}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:1791... | CATALYTIC ACTIVITY: Reaction=All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.; EC=3.4.22.49; Evidence={ECO:0000305|PubMed:25919583}; | null | null | null | null | FUNCTION: Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis (PubMed:11728305, PubMed:12498686, PubMed:20116245, PubMed:21878498). Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) ... | Caenorhabditis elegans |
G5ED46 | CASY1_CAEEL | MRTAYFIFVGALLGVSYAKHHHAARAPIINLQGAEELVAVVREDENIISTVPDFAILSETGPVCNYLLTSQNNEPVPFDIQVVDKYTGAAVLRVKDAATLDCKKPEYNLQVQAVKCDNDNVKSEGVSLKIRVKDTNNHAPEIENPWYTFHVEEGKVVEEVGVLKASDKDCGHPNGEICEYEITNGLKELPFAINNHGVLRTTQPLNFTQSKSYILTVVAIDCAMRKSKSSLVTVHVDEKCVQGITAMNERVNYAPGVGSKLLLPDVSLEFCEKETICEPKSVQSVIELRAGHVTQGCARDTVYDNQTIQSCGLSTATVKL... | null | null | associative learning [GO:0008306]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; olfactory learning [GO:0008355]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; positive regulation of synaptic vesicle transport [GO:1902805... | axon [GO:0030424]; cell surface [GO:0009986]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO... | amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988] | PF00028;PF19699; | 2.60.120.200;2.60.40.60; | Calsyntenin family | PTM: A proportion of the protein is proteolytically cleaved before the transmembrane domain in neurons, leading to release in the extracellular space. {ECO:0000269|PubMed:18381821, ECO:0000269|PubMed:29529030}. | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25035490}; Single-pass type I membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:18381821, ECO:0000269|PubMed:25035490}. Cell projection, axon {ECO:0000269|PubMed:25035490}.; SUBCELLULAR LOCATION: [Secreted calsyntenin-1]: Secreted {ECO:0000... | null | null | null | null | null | FUNCTION: Cell adhesion molecule involved in associative learning and memory (PubMed:18381821, PubMed:19287492, PubMed:25035490, PubMed:29529030). Acts as a regulator of GABAergic synaptic transmission at neuromuscular junctions by regulating GABA synaptic vesicle precursor transport: possibly functions as a cargo adap... | Caenorhabditis elegans |
G5ED47 | HIZR1_CAEEL | MQKVMNDPEDLGNCKICLQRADGIHFAVSSCRACAAFFRRTVILKLNYTCKEKGNCTVEKSLRNLCRSCRYTRCINEGMKIELVQLQRDSIGRKKSGASISIDPLFTPNVASSLSAIFKNEKEDVLSTSCTILSQMTSGYAMFLNIRRSTNTLVQSSVITPTFKMPKIELHASRFDSAKQVCKAEAHLVTDIVNSYFSPFNSLKFEDKVALFKNFFCYFSHTDRAYQSFKQFESDNLNDKILMPDGGFIKRTELGRFYENAEGVHTSAEDAAKIFQPALNYILDVIVDYMRRIHIIETEYLALLGFCLWDDAVPGLSKEA... | null | null | intracellular zinc ion homeostasis [GO:0006882]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:28095401}. Cytoplasm {ECO:0000269|PubMed:28095401}. Note=Localizes to the cytoplasm in the absence of excess zinc, but accumulates in the nucleus when zinc is in excess. {ECO:0000269|PubMed:28095401}. | null | null | null | null | null | FUNCTION: Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote... | Caenorhabditis elegans |
G5ED68 | MTMR6_CAEEL | MRFEDIGISKVDKVCLVDRLGCQENLVGTVHVTTTHIIFRAENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETLQRAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFSARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLF... | 3.1.3.64 | null | endocytosis [GO:0006897]; nematode larval development [GO:0002119]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; regulation of cell migration [GO:0030334]; regulation of Wnt signaling pathway [GO:0030111]; synapse assembly [GO:0007416] | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol phosphate phosphatase complex [GO:1904144]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] | PF01363;PF06602;PF21098; | 2.30.29.30;3.30.40.10; | Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14565969}. Membrane {ECO:0000269|PubMed:14565969}; Peripheral membrane protein {ECO:0000269|PubMed:14565969}. Apical cell membrane {ECO:0000269|PubMed:12788949}; Peripheral membrane protein {ECO:0000269|PubMed:12788949}. | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence={ECO:0000305|PubMed:12788949}; CAT... | null | null | null | null | FUNCTION: May dephosphorylate phosphatidylinositol-3-phosphate (PI3P) (PubMed:12788949, PubMed:14565969). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969, PubMed:21076391). Regulates fluid phase endocytosis in coelomocytes (... | Caenorhabditis elegans |
G5EDA5 | KSRB_CAEEL | MSDEKKKKRGFFRYSVLTTSSFSSWRRSSTSGSISQSSRTTSKTTTSSSVTSSNPINAPPPTATSSSSVLPSTSSEPPPPASAPPRISIYHKMVPSKSKFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKGCLDRVKNDCKITTQYMGGILENAVIQSNKKQWEKPTTASISKSLTTSPTCSTSTTMSPAGVEKNVHKTRKLISMTTSTLDDVTTFNSEINEEMDEETVLMTWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAVRFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTN... | null | null | meiotic cell cycle [GO:0051321]; nematode larval development [GO:0002119]; nematode male tail tip morphogenesis [GO:0045138]; positive regulation of vulval development [GO:0040026]; Ras protein signal transduction [GO:0007265]; vulval development [GO:0040025] | cytoplasm [GO:0005737] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713] | PF07714; | 3.30.60.20;1.10.510.10; | Protein kinase superfamily, TKL Ser/Thr protein kinase family | null | null | null | null | null | null | null | FUNCTION: Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf (PubMed:11882296, PubMed:23900546). In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation (PubMed:11882296, PubMed:265... | Caenorhabditis elegans |
G5EDB2 | MADD3_CAEEL | MPILHQKIASTGGQPSTNSLALRRLPLVVIPRKRKYKNYVSRRRNTQLLASLRRCVSDPNVYKSYNHWKALLRPMTPIKSGAPTPKTVTPMPVPQIPPHQKMTPNPTPTQNPVQLPLPHAVSEKPGDKKSTGPTPSPVPSKAPISAAKLPGTVTKVAPLLSAAQPPPKTLAPAPGASETNSGSGPVSKQVSGKLTELKSKNGTVTEKTEKAVLRIPSSASTRAKAASAVAPEANPAPVPTATKPSPFAPAIAPLRDGAPAQPPAPIQASAPLRPPVAKQNSLQKPPEPKRSVGAPPKALPSELVNKIDGIEFLPQSSNQN... | 2.7.11.- | null | phosphorylation [GO:0016310]; regulation of RNA splicing [GO:0043484] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily | null | SUBCELLULAR LOCATION: [Isoform a]: Cytoplasm {ECO:0000269|PubMed:27123983}. Nucleus {ECO:0000269|PubMed:27123983}. Note=Enriched in the cytoplasm. {ECO:0000269|PubMed:27123983}. | null | null | null | null | null | FUNCTION: [Isoform a]: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to ta... | Caenorhabditis elegans |
G5EDB9 | RPGF_CAEEL | MDPRKPRQDPVNDARFYESLIKPPHLRTPDDIRNVYEQLRQLDTFSNLFIGPLKALCKTARYERHPAQYILFRDGDVARSWYILLSGSVFIENQIYMPYGCFGKRTGQNHRRTHNCLLLQESEMIVIDYPTEPQSNGMSPRTPPRGIHHSGEPVHQKTPRKSAPNMSVDSIAMPPPPVPPRPLRLPQTAAKGPAPLPPRGLPRTYPLDFPVDIPTTSSSSSNTSYNDQHRSQVYLNGLSADEDTLVRVKHRREKSNSVGGQAQNGISTARRLRGRSTASSTTTEGETASNEGADSDEDEGSMPSQESSSGGFMDLRDSVR... | null | null | collagen and cuticulin-based cuticle development [GO:0040002]; epidermis development [GO:0008544]; molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; Ras protein signal transduction [GO:0007265] | apical plasma membrane [GO:0016324]; collagen and cuticulin-based cuticle extracellular matrix [GO:0060102]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] | GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] | PF00595;PF00788;PF00617;PF00618; | 2.30.42.10;2.60.120.10;1.10.840.10;1.20.870.10; | RAPGEF2 family | null | null | null | null | null | null | null | FUNCTION: Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. {ECO:0000269|PubMed:15525675}. | Caenorhabditis elegans |
G5EDE1 | GFI1H_CAEEL | MSTEHVSNVYSVESLLSNVEKSSVSPTESIEDRNEFMITEDVMSSWQRMAATISLQQKLLMMQQTMPRPPPVNILGNFPFGFLNAPMFWQQYLRSMAMGIIPQNPESPSASVWNRTPTPPVEIKPFHCQKCTKLFSTIAALEQHQQVHVSDKQFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCEYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGFKPFACDVCGRTFQRKVDRRRHRESHHPGHPEECVSASQISSDLSPKGYMTPPTSNGYLDSSDEFLNVFRLPAELLAIKAEMGEEM... | null | null | negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast fate specification [GO:0014018]; regulation of backward locomot... | axon [GO:0030424]; nucleus [GO:0005634]; perikaryon [GO:0043204] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcriptio... | PF00096; | 3.30.160.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9169852}. Cell projection, axon {ECO:0000269|PubMed:9169852}. Perikaryon {ECO:0000269|PubMed:9169852}. | null | null | null | null | null | FUNCTION: Transcription factor (PubMed:26096732). Plays a role in the determination of neuroblast cell fate and neuronal differentiation (PubMed:11923211, PubMed:26096732). Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, reg... | Caenorhabditis elegans |
G5EDE2 | CBXH2_CAEEL | MSSKSTKRAKIEDPKDNVFMVEKVLDKRTGKAGRDEFLIQWQGFPESDSSWEPRENLQCVEMLDEFEREFSKREKPIRKRHSQKPEPSEDQADPEEDKDEKKETNQNDKFSLEGKQLKCIVGLTKGPGELHFLCKFSDDTARLLPAKEVNSRYPSQVIRYYESKLTIQDPKADEL | null | null | chromatin organization [GO:0006325]; chromosome attachment to the nuclear envelope [GO:0097240]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; germ cell development [GO:0007281]; gonad development [GO:0008406]; negative regulation of gene expression [GO:0010629]; negative regulati... | chromosome [GO:0005694]; nuclear inner membrane [GO:0005637]; nuclear periphery [GO:0034399]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; H3K27me3 modified histone binding [GO:0061628]; methylated histone binding [GO:0035064] | PF00385;PF01393; | 2.40.50.40; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11850401, ECO:0000269|PubMed:16890929, ECO:0000269|PubMed:16905130, ECO:0000269|PubMed:25467431, ECO:0000269|PubMed:26476455, ECO:0000269|PubMed:29760282}. Chromosome {ECO:0000269|PubMed:11850401, ECO:0000269|PubMed:16890929, ECO:0000269|PubMed:16905130, ECO:0000269|Pub... | null | null | null | null | null | FUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes (PubMed:11850401). Probably does not act as global transcriptional repressor, instead targeting a subset of genes (PubMed:19064713, PubMed:22185090, PubMed:23028351, PubMed:25467431). Involved in RNA processing mediated by Tar... | Caenorhabditis elegans |
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