Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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G5EDE5 | RGMB_CAEEL | MSIVYLVSITFIFSVFKPITSCRVEECAAWFQKTKDYENLVPKATERYCQVLQTYLKCMNDTQRYCHGNLRFHSSELIMRRHWKEFECEKWESCNDNSHVKRKHVNTCYFNPPPSNRKLKYCSLFGDPHLIMFNGSVQTCSEEGARPLVDNRYFLVQVTNRNVRGEALTTTVTKVTVLVRKHNCTASLRYEASSDEEGLPRGFVDGTTFQMTSKHSVEVLWQDDNYVEIALHFIHSSIHIRRQGPYLSVSVRAPTIVLETGGDVARELCWSGCRKSSRIPAELAVEMTKKFAECYRRRVHVPKKVAEDRCKDIGNIGVFF... | null | null | BMP signaling pathway [GO:0030509]; mesodermal cell fate specification [GO:0007501]; positive regulation of multicellular organism growth [GO:0040018]; regulation of BMP signaling pathway [GO:0030510]; regulation of dauer larval development [GO:0061065]; regulation of multicellular organism growth [GO:0040014] | plasma membrane [GO:0005886]; receptor complex [GO:0043235]; side of membrane [GO:0098552] | coreceptor activity [GO:0015026] | PF06534;PF06535; | 3.40.1000.10; | Repulsive guidance molecule (RGM) family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20534671}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. | null | null | null | null | null | FUNCTION: Probably in association with the cell surface receptor unc-40, positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6 (PubMed:24004951). Regulates body size and this may be through modulation of the Sma/Mab signaling pathway (Pu... | Caenorhabditis elegans |
G5EDF0 | GRH1_CAEEL | MSFQLDQSTSVIKTAPPGRLEFKNEPIDIASSNIQDLAKMQTLDGYYQQTSLQLPQSQQYHRMYENVYNNQQILYAQTQNFQYPSTLLTNGSLAQTEWRGQQMDTSAYSNTGYSRSSTSQQPQYTQQVTENERIVYKPVDMPSPVDSGIGGDISILNPKEEFFTSADGGSMLERSSERTLSHRDSPLVIPKLYNNLGFQYVLEAPISTSVRRDDDRMTYVNKGQFYTVSLEYTPDLNKCLKSQTVKSQLMVVFREDKTYEEEIKTWQSWHARQHVSKQRILEIDSKNSSGMIGQIEEIGNNAVQFYWNPSDPSGVRISIA... | null | null | defense response to bacterium [GO:0042742]; determination of adult lifespan [GO:0008340]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837] | PF04516; | null | Grh/CP2 family, Grainyhead subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | null | null | null | null | null | FUNCTION: Probable transcription factor (PubMed:12888489, PubMed:36688410). Binds a motif with the core sequence 5'-C[ACT][TG]G-3' in regulatory elements of target genes (PubMed:12888489, PubMed:36688410). Many putative target genes show oscillating expression levels, perhaps as a result of rhythmic variation in accumu... | Caenorhabditis elegans |
G5EDF7 | SEK1_CAEEL | MERKGRERKLPGMKIVMPTPVETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQF... | 2.7.12.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11751572}; | defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; determination of left/right asymmetry in nervous system [GO:0035545]; innate immune response [GO:0045087]; MAPK cascade [GO:0000165]; negative regulation of endopl... | null | ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [G... | PF00069; | 1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000269|PubMed:11751572}; CATALYTIC... | null | null | null | null | FUNCTION: Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1 (PubMed:11751572). May phosphorylate pmk-1 (PubMed:12142542, PubMed:16166371). Downstream of CaMKII unc-43 and adapter pro... | Caenorhabditis elegans |
G5EDJ0 | FAX1_CAEEL | MSDEDEPLNFSTSKATEESKEGILGVRSIFNTPLLFPPPMFNAGVISPHIAAALAMSFNQQRMNASVSPPLDHTTISVNSFPSMGSVKTDSPPTASSPTLCCAVCGDVSSGKHYGILACNGCSGFFKRSVRRRLIYRCQAGTGNCVVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNTATIRPALDMDPQNFFREYAGAVSAIMGHSNMMKREDSPSSASDGKTEDEKKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLTSLMLKFRRLDVSPAEFNCLKAITIF... | null | null | axon guidance [GO:0007411]; cell differentiation [GO:0030154]; locomotory behavior [GO:0007626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of backward locomotion [GO:0... | axon [GO:0030424]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion bin... | PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10648229, ECO:0000269|PubMed:16183052}. Cell projection, axon {ECO:0000269|PubMed:10648229}. Cytoplasm {ECO:0000269|PubMed:10648229}. | null | null | null | null | null | FUNCTION: Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3' (PubMed:10648229, PubMed:18179707). Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes (PubMed:1... | Caenorhabditis elegans |
G5EDJ4 | SOC1_CAEEL | MSIPDENIILEGSLKRCKKYKLFKTKWVEHYFVLHCRDRERNLFAIDEFKTSRKNDLKKRFKLEFVIRVESNLSVSDPSILCTAGGGHQEESMLNCIFGVGFRFENIVKDLYLVAKNDEEMTLWVNEICKLCKLHRQHDEGDSSHAAESSISGMSMSSQSLDMSIIEQQQYAENIPESKQYHRMHHFKSVISHNSLPSNPNYNNLPDPLESSRSETSSMYSSRRTEDDSVSYTSGPPVPPPRTRHTLNRFVKNGQVGRLHMIPASTSMGQVVKVEDAEDSSGETLKLDTPEQYPESVTSSEGFPVYERNGKTLIRRAPPP... | null | null | dauer larval development [GO:0040024]; signal transduction [GO:0007165] | cytoplasm [GO:0005737] | signaling adaptor activity [GO:0035591] | PF00169; | 2.30.29.30; | null | PTM: May be phosphorylated. {ECO:0000269|PubMed:11689700}. | null | null | null | null | null | null | FUNCTION: Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras (PubMed:11689700). Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole ... | Caenorhabditis elegans |
G5EDK5 | CELR_CAEEL | MMLDRIMFLLFFILSLVIGSFSEYLDDKYYSTNSIDVVCKPCAVPSSNSVIWLPASRPPCLHPGQPIIHWPDLSDNLACPVPGLPDSVHSSQISLLEGEGLLLTKERICFFDGPIDFHYDYVCDGKLYRSKMRIGHSIASKKKLETRRTKRWARRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKASHASSQPLYYSMVAPQDSRSQNLFTLDTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQDNSPIFEKDSYFGEIREDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNGKNLLAI... | null | null | anterior/posterior axon guidance [GO:0033564]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron axon guidance [GO:0097376] | axon [GO:0030424]; dendrite [GO:0030425]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] | PF00002;PF00028;PF00008;PF02210; | 2.60.120.200;2.60.40.60;4.10.1240.10;2.10.25.10;1.20.1070.10; | G-protein coupled receptor 2 family, LN-TM7 subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:20876647}. Cell projection, dendrite {ECO:0000269|PubMed:20876647}. Note=In embryos, localizes to axons in the nerve ring, the tail and along dendrites of sensory neurons. {ECO:0000269... | null | null | null | null | null | FUNCTION: During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation (PubMed:20876647, PubMed:22442082, PubMed:23376536, PubMed:28846083). Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve rin... | Caenorhabditis elegans |
G5EDM4 | NHRF1_CAEEL | MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYA... | null | null | intracellular amino acid homeostasis [GO:0080144]; L-amino acid transport [GO:0015807]; protein localization to plasma membrane [GO:0072659] | amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; microvillus membrane [GO:0031528] | protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102] | PF17820; | 2.30.42.10; | null | PTM: Phosphorylated. {ECO:0000269|PubMed:22916205}. | SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000269|PubMed:22916205}. Apical cell membrane {ECO:0000269|PubMed:22916205}. Note=Co-localizes with aat-6 at the apical cell membrane of intestinal cells. {ECO:0000269|PubMed:22916205}. | null | null | null | null | null | FUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal ... | Caenorhabditis elegans |
G5EDM7 | DAF5_CAEEL | MSDSPIGSSQQVEPEHRTPDLMDIDPLIANLKALHEETRSDDDDDGQPSTSAKRKDSRADGIVIHQKKYSDPGRFLWIWLLGVRVPALSIDGEPHLPIEILDDMLTKKDKKDQMSFQNLLRYKNVYIRMASPSQFRAVMEKSKECENLNITSLSLMSRSDIERIMGELRLESMLTLAEHDNWDISDRVHVVHVNFIDYCSEWLESDDLEEDVMQSGTHGYWYKNRRNMRCIECQHCEGKFTPTDFIMHHHYPIKPSGFVHTGCNSFQWIRLIEVFDKSNENLEAWNKFVLNSHRAGKREYDEAAPHQAPPKRPAMETPVP... | null | null | dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dauer larval development [GO:0061066]; transforming growth factor beta receptor s... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332] | PF08782; | 3.10.390.10; | SKI family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14681186}. | null | null | null | null | null | FUNCTION: Probable component of transcriptional regulatory complex with SMAD protein daf-3 (PubMed:14681186). Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:14681186). Involved in larvae undergoing cell-cycle arrest during th... | Caenorhabditis elegans |
G5EDN0 | ACC3_CAEEL | MIRTRHVFLFAVLLAFASSQTPTPEAKSSEQSLEENKFFPLPPTTPFPTNAVAATDEDGEELCTSDKTIIEKLLNNYKSFRTPSESGVIVWIEVWVQEVNSVNEITSDFDMDIYVTELWMDSALRYEHLNPCKYNLSLNSEILDQIWKPNTVFINSKSANIHKSPFKNVFLMIYPNGTVWVNYRVQVKGPCSMDFSAFPMDQQSCHLTLESFSYNNQEVDMQWMNWTTPLSLLKKEIVLPDFVMSNYSTSLKHEIYPAGVWNELTMTFVFSRRYGWYIFQAYIPTYLTIFISWISFCLGPKMIPARTMLGVNSLLALTFQ... | null | null | chloride transmembrane transport [GO:1902476] | chloride channel complex [GO:0034707]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] | chloride channel activity [GO:0005254]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic me... | PF02931;PF02932; | 2.70.170.10;1.20.58.390; | Ligand-gated ion channel (TC 1.A.9) family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15579462}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. {ECO:0000269|PubMed:15579462}. | Caenorhabditis elegans |
G5EDN3 | TIM_CAEEL | MNVLVQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPF... | null | null | cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; embryo development ending in birth or egg hatching [GO:0009792]; entrainment of circadian clock [GO:0009649]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]; mitotic sister chromatid ... | nucleus [GO:0005634]; replication fork protection complex [GO:0031298] | DNA binding [GO:0003677] | PF04821; | null | Timeless family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10550049, ECO:0000269|PubMed:12827206}. | null | null | null | null | null | FUNCTION: Plays an important role in chromosome cohesion during both mitosis and meiosis (PubMed:12827206). In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosom... | Caenorhabditis elegans |
G5EDN6 | CANB_CAEEL | MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVEHTEVHKKMVLENI | null | null | calcineurin-mediated signaling [GO:0097720]; endocytosis [GO:0006897] | calcineurin complex [GO:0005955]; endoplasmic reticulum [GO:0005783]; sarcomere [GO:0030017]; striated muscle dense body [GO:0055120] | calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902] | PF13499; | 1.10.238.10; | Calcineurin regulatory subunit family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12221132}. | null | null | null | null | null | FUNCTION: Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132). Confers calcium sensitivity (PubMed:12221132). Plays a role in egg-laying, fertility, growth, movement and cuticle development (PubMed:12221132, PubMed:12684004). Plays a role in sensit... | Caenorhabditis elegans |
G5EDP2 | NLTP2_CAEEL | MTPTKPKVYIVGVGMTKFCKPGSVPGWDYPDMVKEAVTTALDDCKMKYSDIQQATVGYLFGGTCCGQRALYEVGLTGIPIFNVNNACASGSSGLFLGKQIIESGNSDVVLCAGFERMAPGSLENLAAPIDDRALSVDKHISVMSETYGLEPAPMTAQMFGNAAKEHMEKYGSKREHYAKIAYKNHLHSVHNPKSQFTKEFSLDQVINARKIYDFMGLLECSPTSDGAAAAVLVSEKFLEKNPRLKAQAVEIVGLKLGTDEPSVFAENSNIKMIGFDMIQKLAKQLWAETKLTPNDVQVIELHDCFAPNELITYEAIGLCP... | 2.3.1.176 | null | acyl-CoA metabolic process [GO:0006637]; ascaroside biosynthetic process [GO:1904070]; dauer entry [GO:0043053]; dauer exit [GO:0043054]; lipid transport [GO:0006869]; negative regulation of lipid storage [GO:0010888]; olfactory learning [GO:0008355]; pheromone biosynthetic process [GO:0042811]; positive regulation of ... | peroxisome [GO:0005777] | acyltransferase activity [GO:0016746]; lipid binding [GO:0008289]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632] | PF02803;PF00108; | 3.40.47.10; | Thiolase-like superfamily, Thiolase family | null | SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:19174521, ECO:0000269|PubMed:19496754}. Note=Punctate localization in the cytoplasm. {ECO:0000269|PubMed:19174521, ECO:0000269|PubMed:19496754}. | CATALYTIC ACTIVITY: Reaction=choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA; Xref=Rhea:RHEA:16865, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373, ChEBI:CHEBI:57392, ChEBI:CHEBI:58507; EC=2.3.1.176; Evidence={ECO:0000269|PubMed:9151950}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=80 uM for 3-ketooctanoyl-CoA (at 25 degrees Celsius) {ECO:0000269|PubMed:9151950}; KM=0.7 uM for CoA (at 25 degrees Celsius) {ECO:0000269|PubMed:9151950}; Vmax=0.1 mmol/min/mg enzyme {ECO:0000269|PubMed:9151950}; | null | null | null | FUNCTION: Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA (PubMed:9151950). Involved in the biosynthesis o... | Caenorhabditis elegans |
G5EDR3 | 2AB1_CAEEL | MVMEVDEPAVAATTSQNQPQEHANDFDMDTSEGPIENDETFEPVDQINWKFNQVKGNIDADVHTEADVISCVEFSHDGEYLATGDKGGRVVIFQRDQSGKYVKGVRSREYNVYSTFQSHEPEFDYLKSLEIDEKINQIRWLKKKNAANFILSTNDKTIKLWKISERERKIGDDAWNLPRTNRINTSSFRGRLQIPSIVPMELIVEASPRRVYGNAHTYHVNSISVNSDQETFLSADDLRVNLWNLEITNESFNIVDIKPANMEELTEVITAAEFHPTQCNWFVYSSSKGSIRLCDMRDRALCDAYAKIFEEPEDPQSRSF... | null | null | centriole assembly [GO:0098534]; embryo development ending in birth or egg hatching [GO:0009792]; nematode larval development [GO:0002119]; positive regulation of vulval development [GO:0040026]; regulation of vulval development [GO:0040028] | cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159] | protein phosphatase regulator activity [GO:0019888] | PF00400; | 2.130.10.10; | Phosphatase 2A regulatory subunit B family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21497766}. | null | null | null | null | null | FUNCTION: Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1 (PubMed:21497766). In addition, during vulva ... | Caenorhabditis elegans |
G5EDR5 | FUTA_CAEEL | MTARSIKLFFARWKYLMFACCITYLLVIYAPISKSEQKDWKEGEIELSNDHELDVPILQKEELKPQQRPSFEENVPKKKTFNFNPVGKEPFDVEEVLTSSDIKLEERMTATVIPGQKRLILSWNAGHSQDNLQGCPDWNCEFTQVRARAPDADAVLIAHMDNDFVPKPNQYVVYFSQESPANSGIQIPRPDYINMTLGFRHDTPAGSPYGYTVKLGAKSRKTGQVVDANLVNGKAKGAAWFVSHCQTNSKREDFVKKLQKHLQIDIYGGCGPMKCARGDSKCDTMLDTDYHFYVTFENSICEDYVTEKLWKSGYQNTIIP... | 2.4.1.214 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:21515584}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:21515584}; Note=Can also use Co(2+) or Ca(2+) in vitro. {ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:2151... | carbohydrate biosynthetic process [GO:0016051]; fucosylation [GO:0036065]; protein glycosylation [GO:0006486] | Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]; metal ion binding [GO:0046872] | PF17039;PF00852; | 3.40.50.11660; | Glycosyltransferase 10 family | PTM: N-glycosylated (PubMed:17369288, PubMed:21515584). Glycosylation is important for enzymatic activity (PubMed:21515584). {ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:21515584}. | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}. | CATALYTIC ACTIVITY: Reaction=GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-be... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 mM for GDP-fucose (at pH 7.5 and 23 degrees Celsius) {ECO:0000269|PubMed:21515584}; KM=400 uM for Man-alpha-1-6(Man-alpha-1-3)Man-alpha-1-6(Man-alpha-1-3)Man-beta-1-4GlcNAc-beta-1-4GlcNAc (at pH 7.5 and 23 degrees Celsius) {ECO:0000269|PubMed:21515584}; | PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:15364955, ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:9675224}. | null | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 23 degrees Celsius. No detectable activity at 37 degrees Celsius. {ECO:0000269|PubMed:17369288}; | FUNCTION: Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans (PubMed:15364955, PubMed:17369288, PubMed:21515584, PubMed:9675224). Unlike in mammals, does not require the prior action of N-ace... | Caenorhabditis elegans |
G5EDS1 | VAB3_CAEEL | MSDAGHTGVNQLGGVFVNGRPLPDATRQRIVDLAHKGCRPCDISRLLQVSNGCVSKILCRYYESGTIRPRAIGGSKPRVATSDVVEKIEDYKRDQPSIFAWEIRDKLLADNICNNETIPSVSSINRVLRNLAAKKEQVTMQTELYDRIRIVDNFPYNSSWYGQWPIPMNGAVGLNPFVPAPLIEPKTEGEFEKDEDQKPPTEPEDDAAARMRLKRKLQRNRTSFTQVQIESLEKEFERTHYPDVFARERLAQKIQLPEARIQVWFSNRRAKWRREEKMRNKRSSGTMDSSLSNGTPTPTPGSVTGSNMTNPIGSPASTPN... | null | null | anterior/posterior pattern specification [GO:0009952]; cell fate commitment [GO:0045165]; negative regulation of distal tip cell migration [GO:1903355]; nematode male tail mating organ morphogenesis [GO:0090597]; nematode male tail tip morphogenesis [GO:0045138]; positive regulation of glial cell differentiation [GO:00... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00046;PF00292; | 1.10.10.60;1.10.10.10; | Paired homeobox family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:7659159}.; SUBCELLULAR LOCATION: [Isoform b]: Nucleus {ECO:0000269|PubMed:7659160, ECO:0000269|PubMed:9858725}. Cytoplasm {ECO:0000269|PubMed:9858725}. Note=Nuclear localization is temporally and spati... | null | null | null | null | null | FUNCTION: Transcription factor that binds a motif with the core sequence 5'-GCGTA-3' in the promoter of various genes (PubMed:11476572, PubMed:30890567). During development, required for cell fate specification probably by promoting or repressing expression of genes involved in specific cell fate (PubMed:11476572, PubM... | Caenorhabditis elegans |
G5EDT1 | LIN35_CAEEL | MPKRAADEPGTSTTDPFHEQSPFDAVLAGTETTDTICEEPPAKRIDLDIKQEFNGGVQSGGLIKNESELTQMTIKQETEGNINEARREEEDEEQDEDSRTSMPPALGEDDDYEEDDADSFIDKTNTPPPSQSFLEGCRAANLPNDIVTGAWETYNHAVQRVSLEGSESAWQLSAIYYYLLSKGIKRRGKTIRILIQPFPVSILTIANSFDISVAEMLDKTARFVEIIHSRKIRRYQEYIRRIQEGLAVSCVIFKKFCRIFCKIFEEIKVGSENCPSSHELFTVLWTSFLVMKSRMTVDDLISNYQLLFSILDQVYTEMCS... | null | null | cell cycle [GO:0007049]; cell differentiation [GO:0030154]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract morphogenesis [GO:0048557]; gonad development [GO:0008406]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of DNA endoreduplic... | chromatin [GO:0000785]; DRM complex [GO:0070176]; nucleus [GO:0005634]; Rb-E2F complex [GO:0035189]; transcription regulator complex [GO:0005667] | RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF11934;PF01858;PF01857; | 1.10.472.140;1.10.472.10; | Retinoblastoma protein (RB) family | PTM: Phosphorylated by the cyclin dependent kinase cdk-4. Phosphorylation inhibits the transcriptional repressor activity of lin-35 and allows for progression through the G1 phase of the cell cycle during postembryonic development. {ECO:0000269|PubMed:25562820}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15621535, ECO:0000269|PubMed:23347407, ECO:0000269|PubMed:25562820, ECO:0000269|PubMed:9875852}. Note=Expressed in dividing cells, but decreased expression after cell cycle exit. {ECO:0000269|PubMed:25562820}. | null | null | null | null | null | FUNCTION: Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated (PubMed:11684669, PubMed:12062054, PubMed:16287966, PubMed:17466069, PubMed:25562820). When unphos... | Caenorhabditis elegans |
G5EDT6 | JKK1_CAEEL | MENVCFQQRLRDLETRVRKWKFLKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQHQRPNNIGYLTSPMERKFTPLSMKPSPSRRDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGL... | 2.7.12.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O14733}; | hyperosmotic response [GO:0006972]; locomotion [GO:0040011]; phosphorylation [GO:0016310]; stress-activated MAPK cascade [GO:0051403] | axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] | ATP binding [GO:0005524]; exonuclease activity [GO:0004527]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | PF00069; | 1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10393177}. Perikaryon {ECO:0000269|PubMed:10393177}. Cell projection, axon {ECO:0000269|PubMed:10393177}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000269|PubMed:10393177}; CATALYTIC... | null | null | null | null | FUNCTION: Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1 (PubMed:10393177, PubMed:15767565, PubMed:17894411). Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downst... | Caenorhabditis elegans |
G5EDU6 | OVOLH_CAEEL | MDSRVWLPLIGAHLLPRDISVITQMIANNNNTSISRSSTNSSKPEEKNSKKFLIERFLDDDPSPPASILSPSPKAAIPSPIINPAVEFVNGGYGVKNPLAPLISSFETTSIPCSTVSPSSLISSSKDEFQDSLTCHICGKKFGLQRLLNRHIKCHSDLKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCEQCEKSFTQRCSLESHLRKVHGVTHQYAYKERRSKVFVCEDCGYTDEKFEVYLSHIKVVHPFSAAYLRFTQLQKKNSSMKPEQLSKISL | null | null | animal organ morphogenesis [GO:0009887]; epidermal cell differentiation [GO:0009913]; hindgut morphogenesis [GO:0007442]; nematode male tail tip morphogenesis [GO:0045138]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to salt stress [GO:... | nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00096; | 3.30.160.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11532910}. | null | null | null | null | null | FUNCTION: Transcription factor (By similarity). Involved in development of the hindgut, the male tail, and the excretory duct cell (PubMed:10511553, PubMed:11532910, PubMed:12231624). Involved in modulating function of excretory duct cells (PubMed:14758362). Plays a role in left/right patterning of cell fates in the hi... | Caenorhabditis elegans |
G5EDW2 | LPLT1_CAEEL | MRRNKTTYSLLQTILVACLLTVTPTFASNKPTTDESGTISHTICDGEAAELSCPAGKVISIVLGNYGRFSVAVCLPDNDIVPSNINCQNHKTKSILEKKCNGDSMCYFTVDKKTFTEDPCPNTPKYLEVKYNCVVPATTTTTTTTTSTTTTDSSLIVDEEEEAQKDALNSDVIKPVKKKEDVFCSATNRRGVNWQNTKSGTTSSAPCPEGSSGKQLWACTEEGQWLTEFPNSAGCESNWISSRNSVLSGVISSEDVSGLPEFLRNLGSETRRPMVGGDLPKVLHLLEKTVNVIAEESWAYQHLPLSNKGAVEVMNYMLRN... | null | null | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; anterior/posterior pattern specification [GO:0009952]; cell surface receptor signaling pathway [GO:0007166]; embryo development ending in birth or egg hatching [GO:0009792]; self proteolysis [GO:0097264]; sexual reproduction [GO:001... | plasma membrane [GO:0005886] | carbohydrate binding [GO:0030246]; endopeptidase activity [GO:0004175]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888] | PF00002;PF16489;PF02140;PF01825;PF02793; | 2.60.120.740;2.60.220.50;4.10.1240.10;1.20.1070.10; | G-protein coupled receptor 2 family, LN-TM7 subfamily | PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000255|PROSITE-ProRule:PRU00098}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19853563}; Multi-pass membrane protein {ECO:0000269|PubMed:19853563}. | null | null | null | null | null | FUNCTION: Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharynge... | Caenorhabditis elegans |
G5EDW5 | ADM2_CAEEL | MTDTLDLKLSSRRQWNPVRCPVRLEVDGSAQTPTSLVQTALNNPSFDLVIAAPNGQNVYIPFTEDRKLFTANIADDPSTSSLISHCHFEGVTEDGRHALSLCDPGEITGLLMTQTNRFGLSTSNNGSFVLIPYVENNCDLGSLVHSSSRKKRQIGKQNTVIDRNPSYIREHLDGRKRFVELALVADYSVYTKYDSDEKKVNDYMQQTMNILNSLYFPLNIRITLVHSEIWKKGDQISVIPDSKETLNNFMEYKKIMLKDHFFDTGYLMTTLKFDEGVVGKAYKGTMCSYDYSGGIYVDHNNDTVETVATFAHELGHTFGM... | 3.4.24.- | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:Q9BZ11}; Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q9BZ11}; | membrane protein ectodomain proteolysis [GO:0006509] | endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] | PF08516;PF00200;PF01421; | 3.40.390.10;4.10.70.10; | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35639786}; Single-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:35639786}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:35639786}; Single-pass membrane protein {ECO:0000255}. Note=Localization and l... | null | null | null | null | null | FUNCTION: Metalloprotease that cleaves and releases a number of molecules (By similarity). Negative regulator of lrp-1 protein levels, potentially by influencing its endosomal trafficking (PubMed:35639786). Involved in regulating the molting process (PubMed:35639786). {ECO:0000250|UniProtKB:Q61072, ECO:0000269|PubMed:3... | Caenorhabditis elegans |
G5EDW7 | LIN8_CAEEL | MSKIKTHSTGSKRTVPFYKLPPPVPLPPLPPPDPTRYFSTEKYIALSKDEKFKFDDYDVNDETLKKVVLNEIGKCPDIWSSRSQAAIMEHYPIVATETYRRTGLLLSIKSLKQIYKCGKDNLRNRLRVAIVSKRLTPAQVEAYMWRWEFYGFIRYYRDYTQRWEADLLKDLDVVLGLEARRASKNMEKVDSGELMEPMEPMDSTMDEMCVEEEPYEETGSNWSDPAPEPSQSKSQSPEAKYPQAYLLPEADEVYNPDDFYQEEHESASNAMYRIAFSQQYGGGGSPAVQKPVTFSAQPAPAPVREAPSPVVENVSSSSFT... | null | null | negative regulation of vulval development [GO:0040027] | nucleus [GO:0005634] | null | PF03353; | null | Lin-8 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16020796}. | null | null | null | null | null | FUNCTION: Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction. {ECO:0000269|PubMed:16020796, ECO:0000269|PubMed:16678779}. | Caenorhabditis elegans |
G5EDY0 | PIKI1_CAEEL | MSDDEELQLAIEISKKTFKDEQKLRSNDLDLIRFESPDEPARQRKINQIKQLYEANSPGPSSYSGSLATSPIDFRPVYNEPRAGPIPHSQSYPRNYFQDWSAIASTSQPPAFPPPPRPPKPEQYKFPPAPSVPLLHDRYFVPPPPPVPPRHSRVQQSPPVPIHPTPPVSSTPLRHSAPSFASDSQQFLSPIKPFEISFNSTVDTSSNQTGSHDHSIQYQPLTHLYVPYVMHSLNSSYGALLNGDLIDLSAFEDSSNASQDEIRKEFDPLFISTYSTDTPSPDNSMPAVNAYFSKPIDEPECVGGAKLIQENIEFPSSSFC... | 2.7.1.137 | null | autophagosome assembly [GO:0000045]; nematode larval development [GO:0002119]; phagosome maturation involved in apoptotic cell clearance [GO:0090386]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulati... | cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endosome [GO:0005768]; peroxisome [GO:0005777]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class III, type I... | 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; phosphatidylinositol binding [GO:0035091] | PF00168;PF00454;PF00613;PF00787; | 2.60.40.150;1.10.1070.11;1.25.40.70;3.30.1520.10; | PI3/PI4-kinase family | null | SUBCELLULAR LOCATION: Cell projection, phagocytic cup {ECO:0000269|PubMed:22272187}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:22272187}; Peripheral membrane protein {ECO:0000269|PubMed:22272187}. Cytoplasm {ECO:0000269|PubMed:22272187}. Note=Localizes transiently to pseudopods and nascent phagosomes ... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence={ECO:0000305... | null | null | null | null | FUNCTION: Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, ... | Caenorhabditis elegans |
G5EDZ2 | UMPS_CAEEL | MSSLTDKTRNGALKRNLLRQMLKASVFKFGEFQLKSGQISPIYIDLRECFGHPGLLMLISEAISKQVEISEVQYAGVLGIPYAALPYASVAAGNYLKKPLLIVRKEAKSYGTKKLIEGLYQPNDRLILIEDVVTTGGSILDVVKVLHTENLVASDVFCILDREQGGRQKLQDAGVTLHSLLDMQTVLTFLYSTGAIGDEQWHGIVQALNLPYTSPTKLEINSELENLSSLPYVENVRTPLAERESLTESALIKKILGIMRRKKSNLCLAVDYTTVEQCLQMIELAGPFVLAIKLHADAITDFNEEFTRKLTTMANDMDFI... | 2.4.2.10; 4.1.1.23 | null | 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract morphogenesis [GO:0048557]; lysosome organization [GO:0007040]; nem... | cytoplasm [GO:0005737] | orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] | PF00215; | 3.40.50.2020;3.20.20.70; | Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20148972}. Note=Localizes near the apical surface of the embryonic intestine. Appears not to localize to gut granules. {ECO:0000269|PubMed:20148972}. | CATALYTIC ACTIVITY: Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380, ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538, ChEBI:CHEBI:58017; EC=2.4.2.10; Evidence={ECO:0000269|PubMed:19645718}; CATALYTIC ACTIVITY: Reaction=H(+) + orotidine 5'-ph... | null | PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. {ECO:0000269|PubMed:19645718}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. {ECO:0000269|PubMed:19645718}. | null | null | FUNCTION: Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis (PubMed:19645718). May also form UMP from uracil (PubMed:19645718). Regulates the size of gut granules during embryonic development (PubMed:20148972). Involved in resistance to DNA damaging ... | Caenorhabditis elegans |
G5EE01 | PTEN_CAEEL | MVTPPPDVPSTSTRSMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQLIGVYVERPPKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERATWLNNCDTPNEFDTGEQKYHGFVSKRAYCFMVP... | 3.1.3.16; 3.1.3.48; 3.1.3.67 | null | cell motility [GO:0048870]; chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; dauer larval development [GO:0040024]; dephosphorylation [GO:0016311]; determination of adult lifespan [GO:0008340]; learning or memory [GO:0007611]; negative regulation of cell population proliferation [GO:0008285]; phosphatidylin... | axon [GO:0030424]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein phosphatase inhibitor complex [GO:0062049] | lipid binding [GO:0008289]; myosin phosphatase activity [GO:0017018]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725] | PF10409;PF00102; | 2.60.40.1110;3.90.190.10; | PTEN phosphatase protein family | PTM: Phosphorylated by vab-1 on tyrosine residues which may promote daf-18 degradation. {ECO:0000269|PubMed:19853560}. | SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:22069193}. Cell membrane {ECO:0000269|PubMed:22916028}; Peripheral membrane protein {ECO:0000269|PubMed:22916028}. Cell projection, axon {ECO:0000269|PubMed:22069193}. Cell projection, dendrite {ECO:0000269|PubMed:22069193}. Cytoplasm {ECO:0000269|PubMed:22916028}. N... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:25017, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456; EC=3.1.3.67; Evidence={ECO:0000... | null | null | null | null | FUNCTION: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate (PubMed:15637588). By depho... | Caenorhabditis elegans |
G5EE06 | FUTD_CAEEL | MKHNTLRAVFQFSFFIGICTFIMIAGYSYQINYNQRMGIFYGGNITFKKVPKVVIYTATPFFDVPIENSILRDCSEKIKNSCTVTSNNKTFPIADAIVFHSRDINETKLSFFNKNRRYDIPYIMMAMENPFFAGLTVYHNFFNWTMTYRTDSDIFHPYGAFVKSYVPAEVNYSEIWNSKTKETLWMVSNGNAQNKRKELVEKLIKKGMSIDLYGQLYKKEPAECPRRRGPPGCDVKFHSPYKFAIAFENSNCKDYVTEKFWKKAGIYKTVPIVMSRKIYRDLGIPDSMYIAVDDYPNLEEFVHHIQNVTSNEEEYMKYHK... | 2.4.1.65 | COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:17369288}; | fucosylation [GO:0036065]; protein glycosylation [GO:0006486] | Golgi cisterna membrane [GO:0032580] | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; metal ion binding [GO:0046872] | PF17039;PF00852; | 3.40.50.11660; | Glycosyltransferase 10 family | PTM: N-glycosylated. {ECO:0000269|PubMed:17369288}. | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}. | CATALYTIC ACTIVITY: Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:23628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:13350... | null | PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:17369288}. | null | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 23 degrees Celsius. Vey low activity at 37 degrees Celsius. {ECO:0000269|PubMed:17369288}; | FUNCTION: Catalyzes the addition of fucose in alpha 1-3 linkage to GalNAc-beta-1->4-GlcNAc-beta-1->3-Gal-beta-1->4-Glc (LDNT)acceptor. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->... | Caenorhabditis elegans |
G5EE07 | XBP1_CAEEL | MSNYPKRIYVLPARHVAAPQPQRMAPKRALPTEQVVAQLLGDDMGPSGPRKRERLNHLSQEEKMDRRKLKNRVAAQNARDKKKERSAKIEDVMRDLVEENRRLRAENERLRRQNKNLMNQQNESVMYMEENNENLMNSNDACIYQNVVYEEEVVGEVAPVVVVGGEDRRAFESAAFINEPQQWEQARSTSINNNISNQLRRMDSKKNNTISVDMYLTIISILCNHMDRNKKMDTSNKSSNISRAQAESSIDSLLATLRKEQTVMQRLVQADPCTHLQKRVKHFRRIP | null | null | defense response to Gram-negative bacterium [GO:0050829]; determination of adult lifespan [GO:0008340]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; IRE1-mediated unfolded protein response [GO:0036498]; lipid homeostasis [GO:0055088]; positive regulation of transcription by R... | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF07716; | 1.20.5.170; | null | PTM: [Isoform 2]: Sumoylated (PubMed:24933177). Sumoylation may negatively modulate the transcription of genes involved in the ER-stress-response (PubMed:24933177). {ECO:0000269|PubMed:24933177}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. | null | null | null | null | null | FUNCTION: Required for transcriptional regulation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) under stressed conditions, acting downstream of ire-1, and also maintaining ER homeostasis via a negative feedback loop, in parallel with ER kinase pek-1 (PubMed:11779465, PubMed:11780124, PubMed:1... | Caenorhabditis elegans |
G5EE18 | CEH28_CAEEL | MQSTQISSTTVILPSEVIQPPQQSAVPSEFKNTLPSRLNLFEGFDQSFSELTNPYQPVIPLMQRESLLGASSYYSSPSQNQRSYQNHRQHSNPDTINLRSQQQKRKPRVLFTQHQVNELEERFKKQRYVTATEREELAQCLGLTATQVKIWFQNRRYKCKRLAQDRTLQLSQIPFNPMFASAFPFGINSFGTAPSSSSSGS | null | null | cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664]; regulation of synapse organization [GO:0050807]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatio... | chromatin [GO:0000785]; nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00046; | 1.10.10.60; | NK-2 homeobox family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682}. | null | null | null | null | null | FUNCTION: Probable transcription factor that regulates neuronal differention, including synapse assembly of the cholinergic motor neuron M4 (PubMed:24690231, PubMed:25474681). Activates expression of growth factor, neuropeptide and transcription factor genes, such as TGF-beta dbl-1, FMRFamide-like flp-5 and transcripti... | Caenorhabditis elegans |
G5EE56 | SRC1_CAEEL | MGCLFSKERRSGGSDMGVSERIDVSRFQTPQQQTVFHVNNGGNEGTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKL... | 2.7.10.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305|PubMed:20226672}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:20226672}; | anterior/posterior axis specification, embryo [GO:0008595]; cell differentiation [GO:0030154]; commissural neuron axon guidance [GO:0071679]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal cell fate specification [GO:0001714]; establishm... | cell projection [GO:0042995]; contractile fiber [GO:0043292]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; phagocytic cup [GO:0001891] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; netrin receptor binding [GO:1990890]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] | PF07714;PF00017;PF00018; | 3.30.505.10;2.30.30.40;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, SRC subfamily | PTM: May be phosphorylated on Tyr-528 by csk-1. {ECO:0000269|PubMed:12527374}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20226672}; Lipid-anchor {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:20226672}. Cell projection, phagocytic cup {ECO:0000269|PubMed:20226672}. Note=Co-localizes with ina-1 at the site of the phagosomal cup formation during apoptotic cell engulfment. {ECO:00... | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000269|PubMed:12527374, ECO:0... | null | null | null | null | FUNCTION: Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:1252... | Caenorhabditis elegans |
G5EE72 | MRP5_CAEEL | MPSDSEEVCLQQSGTGVYENVVYSKETSDRAKRYAGDTNRKTIGRYSAAVQNLIPLRTTERNKNNGGSRIDDAGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVLWEDEKKANAKSPSLFKVIYRFISTRLWFSCAVFFFCLIFGFIGPTCFIRRLIAFAENPERDEQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLNSKDLCGKTESDVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLLMVIGRWSLLGILVFFVFDVIQFGLGKSMVACRNLA... | null | null | cobalamin transport [GO:0015889]; transmembrane transport [GO:0055085] | basolateral plasma membrane [GO:0016323]; membrane [GO:0016020] | ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626] | PF00664;PF00005; | 1.20.1560.10;3.40.50.300; | ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily | null | SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:24836561}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments (PubMed:24836561, PubMed:28581477). Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development (PubMed:29562169). {ECO:0000269|PubMed:... | Caenorhabditis elegans |
G5EE86 | TTX3_CAEEL | MYFQSLSADPLDSVNTTTDFNQLAQLLLMLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAK... | null | null | associative learning [GO:0008306]; axonogenesis [GO:0007409]; dauer larval development [GO:0040024]; negative adaptation of signaling pathway [GO:0022401]; neuron differentiation [GO:0030182]; olfactory learning [GO:0008355]; positive regulation of dauer larval development [GO:0061066]; positive regulation of DNA-templ... | axon [GO:0030424]; nucleus [GO:0005634]; perikaryon [GO:0043204] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription r... | PF00046;PF00412; | 2.10.110.10;1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}. Perikaryon {ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}. Cell projection, axon {ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}. | null | null | null | null | null | FUNCTION: Transcription factor (PubMed:15177025, PubMed:19386265). Binds to a sequence motif, 5'-TTATTGGCTTCGTTAA-3', which may be involved in AIY interneuron function, in the regulatory elements of target genes; binding is more efficient, in vitro, together with homeobox protein ceh-10 (PubMed:15177025). Required for ... | Caenorhabditis elegans |
G5EE96 | DIC_CAEEL | MAEDKTKRLGRWYFGGVAGAMAACCTHPLDLLKVQLQTQQQGKLTIGQLSLKIYKNDGILAFYNGVSASVLRQLTYSTTRFGIYETVKKQLPQDQPLPFYQKALLAGFAGACGGMVGTPGDLVNVRMQNDSKLPLEQRRNYKHALDGLVRITREEGFMKMFNGATMATSRAILMTIGQLSFYDQIKQTLISSGVAEDNLQTHFASSISAASVATVMTQPLDVMKTRMMNAAPGEFKGILDCFMFTAKLGPMGFFKGFIPAWARLAPHTVLTFIFFEQLRLKFGYAPPVKA | null | null | lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; thiosulfate transport [GO:0015709] | mitochondrial inner membrane [GO:0005743] | antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0... | PF00153; | 1.50.40.10; | Mitochondrial carrier (TC 2.A.29) family | null | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9QZD8}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in); Xref=Rhea:RHEA:71607, ChEBI:CHEBI:15589, ChEBI:CHEBI:43474; Evidence={ECO:0000269|PubMed:9733776}; CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in); Xref=Rhea:RHEA:71611, ChEBI:CHE... | null | null | null | null | FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:9733776). Plays an important role in gluconeogenesis, fatty acid metabolis... | Caenorhabditis elegans |
G5EEA1 | LIM4_CAEEL | MDAHLVQAKKTSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFSSSDESSVYISSALRLADYAFTPDDNIRIKPDAVIVICTQCQHQIQDKFFLSIDGRNYHENCLQCSTCENPLSNKCFYKDKTFYCKGCYFRTHVTSTASSCRELGPKCASCDRTIQATDWVRRARNYVYHLACFSCNQCKRQLSTGEEYALQEGNLLCKQHFLELVEGDSGVSSQKAKTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKKWHQKSEGDNGDSQRSSVGPSSPSQ... | null | null | cell fate specification [GO:0001708]; forebrain neuron development [GO:0021884]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcrip... | nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF00046;PF00412; | 2.10.110.10;1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682}. | null | null | null | null | null | FUNCTION: Transcription factor that binds to the promoter of target genes (PubMed:16168406, PubMed:26305787, PubMed:26341465). Regulates genes involved in serotonin synthesis and release in serotonergic ADF neurons (PubMed:16168406, PubMed:26305787). Involved in specification of neuron cell fate, olfactory receptor exp... | Caenorhabditis elegans |
G5EEB1 | FPR18_CAEEL | MESQQLMACAILVIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSLSTYMAYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNAILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVGYYTILYIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLPFLLNVSESIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQTLVFILKNGCCATVSDYNNYTAM... | null | null | G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of protein secretion [GO:0050714]; signal transduction [GO:0007165]; sleep [GO:0030431] | plasma membrane [GO:0005886] | G protein-coupled receptor activity [GO:0004930] | PF00001; | 1.20.1070.10; | G-protein coupled receptor 1 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: G-protein coupled receptor for flp-2 neuropeptides (PubMed:15809090, PubMed:24533288). May act through the G(q) alpha type of G proteins (PubMed:15809090, PubMed:24533288). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in... | Caenorhabditis elegans |
G5EEC2 | FLP7_CAEEL | MLGSRFLLLALGLLVLVLAEESAEQQVQEPTELEKSGEQLSEEDLIDEQKRTPMQRSSMVRFGRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMERSAMVRFGRSPMDRSKMVRFGRSSIDRASMVRLGKRTPMQRSSMVRFGKRSMEFEMQSNEKNIEDSE | null | null | negative regulation of locomotion [GO:0040013]; neuropeptide signaling pathway [GO:0007218] | extracellular space [GO:0005615] | neuropeptide receptor binding [GO:0071855] | PF01581; | null | FARP (FMRFamide related peptide) family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28128367}. Note=Secreted from the ASI sensory neurons in response to serotonin or octopamine. {ECO:0000269|PubMed:28128367}. | null | null | null | null | null | FUNCTION: FMRFamide-like neuropeptides (PubMed:16377032, PubMed:28128367). Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss (PubMed:33078707). Together with atfs-1, negatively regulates the expression of the tran... | Caenorhabditis elegans |
G5EEC5 | HAM1_CAEEL | MTYLAVVLNGPKAKNGRKVFDSFLEQNRQMFWNRELTSACESITYMGFMRPGTLFVSGPASQLTVLKDAWARRILKPAMGYTITSLGDLGAIQQVEQMHFVPLGDVICDAVAQLNRQGLAATEQAIRQYVARHCPHVAPPGIEMVRQTITSLLSTGFVYKMADHYFVSVPTNSPMRPPAKAATKTTKTTVECQTGASMMCPQQTSTSSDEHVIEPAKKDHKKCQNSNRRSIFARLFSRGMKPQTIMPSASPIHVGGPPTPPPAAMLPTKNKYPTYHHDLNEECQRKARRRNHPRRGETQKLLSSSSECLKYYPVDMPETR... | null | null | anterior/posterior pattern specification [GO:0009952]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization involved in cell fate determination [GO:0045167]; cell fate determination [GO:0001709]; dopaminergic neuron differentiation [GO:0071542]; neuron apoptotic process [GO:0051402]; neuron migr... | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF10264; | null | null | null | SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:15979607, ECO:0000269|PubMed:26703426}. Nucleus {ECO:0000269|PubMed:23946438, ECO:0000269|PubMed:26703426}. Cytoplasm {ECO:0000269|PubMed:23946438, ECO:0000269|PubMed:26703426}. Note=Distributed asymmetrically in the cell cortex in some embryonic cells, i... | null | null | null | null | null | FUNCTION: Probable transcription factor (PubMed:23946438). Required for asymmetric cell division in neuroblasts, perhaps acting by regulating spindle positioning and myosin polarization, and thus the position of the cleavage plane (PubMed:15979607, PubMed:18505863, PubMed:23946438, PubMed:26703426, PubMed:3200316, PubM... | Caenorhabditis elegans |
G5EED4 | NIPI3_CAEEL | MARTKCKTKTVANPRTGVRKTAKDLSEPVRQDAVSRRRPTTLPFVGNTSSRPRVFYDVLAKKNVVFPNVKAEYHYRVRNAPKIDPKNFGTTLPICYSSIGPAKTLELRPLGRLPPHIIKALNDHYVQLTRGSMVPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLVNGEIIGIFVIYGTGLVTRAVCSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHS... | null | null | defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of proteasomal ubiquitin-dependent pr... | nucleus [GO:0005634] | ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CAMK Ser/Thr protein kinase family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27927209}. | null | null | null | null | null | FUNCTION: Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability (PubMed:27927209). Involved in negatively modulating pmk-1 p38/MAPK signaling (PubMed:27927209). Involved in innate immunity, acting either in a manner dependent upon, or independent of, ... | Caenorhabditis elegans |
G5EEE1 | FUTE_CAEEL | MSQIGGATCTWRYLGRFVTLGIYASVALFVWYTLVPTRSKHKDSIAINNNNADPATALIPVHTKNVVIYAATKFFGHPITTERFLATCPDVQNYCRITQEESEFDNADAVLFHNADYRGSTDKFKKMKSQRKPGVPYVLWSLESPTNDMFRPDSHMINWTMTYRTDSDVWAPYGTIVKLKNPVEVDLNAIWEGKTKTATWLASNCITQNHRFDLIKKIIDNGFEIDIWGNCGKQVSQCAGVDNQESPCVLELIKPYKFYISMENSNCKDYVTEKFWKALNDRMTIPIVLARKYYKDLGVPDSAYIAVDDYATLDEFLAHV... | 2.4.1.- | COFACTOR: Note=Unlike other alpha-(1,3)-fucosyltransferases, appears not to require a divalent metal cation as cofactor. {ECO:0000269|PubMed:17369288}; | fucosylation [GO:0036065]; protein glycosylation [GO:0006486] | Golgi cisterna membrane [GO:0032580] | alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] | PF17039;PF00852; | 3.40.50.11660; | Glycosyltransferase 10 family | null | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}. | null | null | PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:17369288, ECO:0000269|PubMed:23754284, ECO:0000269|PubMed:26002521, ECO:0000269|PubMed:26538210}. | null | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 23 degrees Celsius. Very low activity at 37 degrees Celsius. {ECO:0000269|PubMed:17369288}; | FUNCTION: Involved in the fucosylation of N-glycans (PubMed:15364955, PubMed:17369288, PubMed:23754284, PubMed:26002521, PubMed:26538210). Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans (PubMed:23754284). Catalyzes the transfer of fucose to Gal-beta-1-4-Gl... | Caenorhabditis elegans |
G5EEE9 | GCY23_CAEEL | MRRELFIFLLLLGECANVKVKVGHIGAVGSMRNAEKILQLSKEQLTQEGVLGNDFDIEILNQMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAKMATFWNIPVVGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVAIATNTGAVAFERVQSFEEVFHQRGINVVRKIMLEEYTNAKAIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNNANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYSTDDLEMKNIYGYIHL... | 4.6.1.2 | null | cGMP biosynthetic process [GO:0006182]; detection of temperature stimulus [GO:0016048]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052] | cilium [GO:0005929]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886] | adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; metal ion binding [GO:0046872]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672] | PF01094;PF00211;PF07714; | 3.40.50.2300;3.30.70.1230;1.10.510.10; | Adenylyl cyclase class-4/guanylyl cyclase family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:16415369}. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons. {ECO:0000269|PubMed:16415369}. | CATALYTIC ACTIVITY: Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence={ECO:0000250|UniProtKB:Q19187}; | null | null | null | null | FUNCTION: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369). {ECO:0000250|UniProtKB:Q19187, ECO:0000269|PubMed:16415369... | Caenorhabditis elegans |
G5EEG1 | NFYA1_CAEEL | MNGASRGDVQRPTPVQAPAKRPIPPTVFRFEKASKIGTSLDTTPKELPIRRPVPLPGPRFVKDVNPSPPATSSPNVQTQCHQPPVVRSQTHQASVSQTTPTQTTPSQYTPASVSTARAPQFHRSSHVTPSQQQRIEQAFGPAPVSQSQPQNGSYIQYNEPSTSVASTTTSFYSPNESEPVFTHAISFKPNEPENGQKAREQLELLDSGKINEINQSKVPTTIELPPNCKLFQYSWVLDGIPRTLLVPMPMDATEEDVKAMLPKTLEMDSNLFNNARPRDELPVLSFPNGTVPNVEMIGPKVQQPMLVNPKQFNRIMRRRE... | null | null | negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of nematode male tail tip morphogenesis [GO:0110039]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue development [GO:0009888] | CCAAT-binding factor complex [GO:0016602]; nucleus [GO:0005634] | DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217] | PF02045; | 6.10.250.2430; | NFYA/HAP2 subunit family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17574230}. | null | null | null | null | null | FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the... | Caenorhabditis elegans |
G5EEG7 | SMU1_CAEEL | MSSIEIESSDVIRLIEQFLKESNLHRTLAILQEETNVSLNTVDSIDGFCNEITSGNWDNVLKTVQSLKLPAKKLIDLYEHVIIELVELRELATARLVARQTDPMILLKQIDPDRFARLESLINRPYFDGQEVYGDVSKEKRRSVIAQTLSSEVHVVAPSRLLSLLGQSLKWQLHQGLLPPGTAIDLFRGKAAQKEQIEERYPTMMARSIKFSTKSYPESAVFSPDANYLVSGSKDGFIEVWNYMNGKLRKDLKYQAQDNLMMMDAAVRCISFSRDSEMLATGSIDGKIKVWKVETGDCLRRFDRAHTKGVCAVRFSKDNS... | null | null | embryo development ending in birth or egg hatching [GO:0009792]; locomotion [GO:0040011]; mechanosensory behavior [GO:0007638]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ morphogenesis [GO:0048644]; nematode larval development [GO:0002119]; neuron development [GO:0048666]; regulation of alternative mRNA ... | nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | PF17814;PF00400; | 2.130.10.10; | WD repeat SMU1 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11438655, ECO:0000269|PubMed:15254247}. | null | null | null | null | null | FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52... | Caenorhabditis elegans |
G5EEG9 | HLH2_CAEEL | MADPNSQLTSATTVATAAIAQPQVMLPNAYDYPYNIDPTTIQMPDYWSGYHLNPYPPMQTTDIDYSSAFLPTHPPTETPASVAAPTSATSDIKPIHATSSTSTTAPSTAPAPTSTTDVLELKPTTAPATNSAETSAIVAPQPLTNLTAPIDAMSSMYTWPQTYPGYLPPSEDNKASEAVNPYISIPPTYTFGADPSVADFSSYQQQLAGQPNGLGGDTNLVDYNHQFPPAGMSPHFDPNGYPGMTGMPPGSSASSVRNDKSASRATSRRRVQGPPSSGIPTRHSSSSRLSDNESMSDDKDTDRRSQNNARERVRVRDINS... | null | null | basement membrane disassembly [GO:0034769]; body morphogenesis [GO:0010171]; cell fate specification [GO:0001708]; embryo development ending in birth or egg hatching [GO:0009792]; germ-line stem cell population maintenance [GO:0030718]; gonad development [GO:0008406]; gonad morphogenesis [GO:0035262]; nematode larval d... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA po... | PF00010; | 4.10.280.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076762}. | null | null | null | null | null | FUNCTION: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:11076762, PubMed:14701877, PubMed:19632181). Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision; required for VU fate (PubMed:14701877, PubMed:31402303). Regulates expression of lin-12/Notch receptor a... | Caenorhabditis elegans |
G5EEH5 | MXL1_CAEEL | MSDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANGERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ | null | null | determination of adult lifespan [GO:0008340]; positive regulation of transcription by RNA polymerase II [GO:0045944] | nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] | DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982] | PF00010; | 4.10.280.10; | MAX family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. | null | null | null | null | null | FUNCTION: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1 (PubMed:9764821). Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like sign... | Caenorhabditis elegans |
G5EEH9 | NUP98_CAEEL | MFGQNKSFGSSSFGGGSSGSGLFGQNNQNNQNKGLFGQPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGSPQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFGASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTGTTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNANTSAASGSLFGAKPAGSSLFGSTATTGASTFGQTTGSSLFGNQQPQTNTGGSL... | 3.4.21.- | null | cell division [GO:0051301]; embryo development ending in birth or egg hatching [GO:0009792]; mitotic chromosome centromere condensation [GO:1990893]; mRNA transport [GO:0051028]; nuclear pore localization [GO:0051664]; nucleus organization [GO:0006997]; P granule organization [GO:0030719]; post-transcriptional tetherin... | cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; P granule [GO:0043186] | nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056] | PF04096;PF13634;PF12110;PF21240; | 1.10.10.2360;1.25.40.690;3.30.1610.10; | Nucleoporin GLFG family | PTM: The Nup98 and Nup96 chains are autoproteolytically processed from a single precursor protein. {ECO:0000269|PubMed:20335358}. | SUBCELLULAR LOCATION: [Nuclear pore complex protein Nup98]: Cytoplasmic granule {ECO:0000269|PubMed:20335358}. Nucleus membrane {ECO:0000269|PubMed:12937276, ECO:0000269|PubMed:20335358, ECO:0000269|PubMed:28122936}; Peripheral membrane protein {ECO:0000269|PubMed:20335358}; Nucleoplasmic side {ECO:0000269|PubMed:20335... | null | null | null | null | null | FUNCTION: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC) (PubMed:20335358, PubMed:28122936). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution (PubMed:28122936). Regulates nucleoporin npp-5 loc... | Caenorhabditis elegans |
G5EEI4 | ASP1_CAEEL | MQTFVLLALVAACSAAVIQVPTHKTESLRAKLIKEGKYTAFLASQHAARAQQLNTGFQPFVDYFDDFYLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKETRKFSIQYGSGSCNGYLGKDVLNFGGLTVQSQEFGVSTHLADVFGYQPVDGILGLGWPALAVDQVVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAVGTYSETKKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQP... | 3.4.23.- | null | programmed cell death [GO:0012501]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; external side of apical plasma membrane [GO:0098591]; extracellular region [GO:0005576]; lysosome [GO:0005764] | aspartic-type endopeptidase activity [GO:0004190] | PF07966;PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10854422}. Lysosome {ECO:0000305|PubMed:10854422}. Secreted {ECO:0000305}. | null | null | null | null | null | FUNCTION: Aspartic protease, which is part of the necrosis cell death pathway (PubMed:12410314, PubMed:26795495). Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells (PubMed:26795495). Cry6Aa uptake into the host i... | Caenorhabditis elegans |
G5EEK3 | NOCA1_CAEEL | MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDRPKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNSSTPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLSQRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFSVDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQRVRSYNNSQFQASDLSLNPNGSIRAACDSTSG... | null | null | cytoplasmic microtubule organization [GO:0031122]; germ cell development [GO:0007281]; nematode larval development [GO:0002119] | adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; hemidesmosome [GO:0030056]; microtubule [GO:0005874] | null | null | null | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26371552}. Apical cell membrane {ECO:0000269|PubMed:26371552}. Cell junction, hemidesmosome {ECO:0000269|PubMed:26586219}. Cell junction, adherens junction {ECO:0000269|PubMed:26586219}. Note=Isoform h: Co-localizes with gamma-tubulin to the apical cell ... | null | null | null | null | null | FUNCTION: Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis (PubMed:26371552). Required for microtubule stabi... | Caenorhabditis elegans |
G5EEK9 | VPP2_CAEEL | MGSLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKLRFLESQIVKDEIVIPGRVDTGDYTILPTSELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKEWDAVLDKTDEFFQGGVDDQAQEELENLDEEGAVPRVEKGPVNYLVGIIRRERLNGFERVLWRACHHTAYIRSSDIEEELEDPGTGEKVHKSVFIIFLKGDRMRSIVEKVCDGFKAKLFKNCPKTFKERQSARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQVRMIKTVFHMLNLFTFDGIGR... | null | null | collagen and cuticulin-based cuticle development [GO:0040002]; exosomal secretion [GO:1990182]; multicellular organismal-level water homeostasis [GO:0050891]; nematode larval development [GO:0002119]; regulation of secretion [GO:0051046]; vacuolar acidification [GO:0007035] | apical plasma membrane [GO:0016324]; cell body membrane [GO:0044298]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar prot... | ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | PF01496; | null | V-ATPase 116 kDa subunit family | null | SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11441002, ECO:0000269|PubMed:16785323}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:16785323}; Multi-pass membrane protein {ECO:0000255}. Note=In embryos, localizes to dot-like compartments or in cup... | null | null | null | null | null | FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartmen... | Caenorhabditis elegans |
G5EEL0 | LIDB1_CAEEL | MYGHHPDYGYGNYGHPPPFAGPESSNSHYGMPPSQGTNSQNNMMMRSQATEPQPIGNTVSPLEFRIHDMNRRLYIFSSTGVSENDQQQWWDAFSHEFFDDDCKLWFVIGSEPVAFASRERYIINRQFIPKFFRSIFDSGMRELQYVLRGPSRECTLANGSQAYENENVLQITRYDQSSQFEVNTEGKLYVEFAPFDEVMNYRIKAWTLELKRSNEFVYNQNTADYRVEAQNPEQENKPRMGFFKSTFNLMTMLKILDPMQSIMSSAKSAPAITPREVMKRTLFQHHQVRQQNMRQQQLNQQMMIPAPEPEKPKPARKRQR... | null | null | locomotion [GO:0040011]; mechanosensory behavior [GO:0007638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vulval development [GO:0040026]; protein localiza... | nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; LIM domain binding [GO:0030274] | PF17916;PF01803; | 2.10.110.10; | LDB family | null | null | null | null | null | null | null | FUNCTION: Binds to the LIM domain of LIM domain-containing transcription factors (PubMed:10993673). Required for the blmp-1-mediated transcriptional activation or repression of several hypodermal genes, such as bed-3 (PubMed:32417234). Regulates sam-10 nuclear localization in PLM neurons (PubMed:21115607). Has a role i... | Caenorhabditis elegans |
G5EEL5 | DBL1_CAEEL | MNDSVRTTTTISSTKSLVHSFQLSAILHLFLLISFTPMSAAADQHASHATRRGLLRKLGLEHVPVQTGPSIDVPQHMWDIYDDDNDVDWVRHYYPKEIIEDNEGFLLSYNLSLAARNAHNEEVTKATLKLRLRRNNKARRSGNISIYFFEDDINNDRFQIESRSVDNLTEWIDFDVTAAFLRRTNRISFFIDLPEDVEIEETQSSSLSSLPYARAQSAPLIVFSDLSEPSSVRRKRSAQTGNSERKNRKKGRKHHNTEAESNLCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNATNHAIIQSLLHSL... | null | null | BMP signaling pathway [GO:0030509]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; nematode larval development [GO:0002119]; nematode male tail tip morphogenesis [GO:0045138... | extracellular space [GO:0005615] | BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083] | PF00019; | 2.60.120.970;2.10.90.10; | TGF-beta family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. | null | null | null | null | null | FUNCTION: Ligand for the serine/threonine-protein kinase receptor type-1 sma-6 which activates a TGF-beta-like signaling pathway (PubMed:24004951). Multifunctional protein that is involved in body size, male ectodermal patterning, innate immunity, lipid metabolism and neural plasticity (PubMed:10021351, PubMed:12176330... | Caenorhabditis elegans |
G5EEM0 | NH114_CAEEL | MTPQSSPSSSRDHVCLVCQDFASGYHYGVPSCVGCKTFFRRTIMKKQKYICQFEGNCPVDKTIRCACRYCRFEKCLSVGMDRNALQQNRDPIGYTKRTRRPKKELKTTSDCSSDEGASTPPSVSPLQLSPPPISPLLFQAAPLKPRRCILQTLAEREKCANDLRLSEYLPIRSLHEALCSKALLNDTAFLEKWGQPSERHQIFDLRFVNHDDYHYWHERDWFLLTEYAKTFDVFEALDYQDKAELVRHAAITVPVLVQVWNSPDYGPDTIVFPDGAYFDRTPEPTRPAGLNRKKYQMLDLVLKPFRDLQLDATEFAAFKA... | null | null | cell differentiation [GO:0030154]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; S-adenosylmethionine cycle [GO:0033353] | nucleus [GO:0005634] | nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU004334, ECO:0000269|PubMed:18629017, ECO:0000269|PubMed:23499532}. | null | null | null | null | null | FUNCTION: Probable transcription factor which may have a role in detoxifying dietary metabolites arising from bacterial tryptophan metabolism (PubMed:23499532). Required for fertility and involved in proper postembryonic germline development, especially germline stem cell (GSC) proliferation (PubMed:23499532). Required... | Caenorhabditis elegans |
G5EEM5 | ZYG9_CAEEL | MSNWDYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKDANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKPMLREPLVDCSNEVGRTMQSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVREASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPTSSTPSASAASGDPSGGTATAVVSSGAPVAEADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKE... | null | null | cell division [GO:0051301]; centrosome duplication [GO:0051298]; embryo development ending in birth or egg hatching [GO:0009792]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; meiotic spindle organization [GO:0000212]; microtubule polymerization [GO:0046785]; microtubule-based process ... | centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922] | microtubule binding [GO:0008017]; microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010] | PF21041; | 1.25.10.10; | TOG/XMAP215 family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10085292, ECO:0000269|PubMed:12011109, ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:17666432, ECO:0000269|PubMed:9606208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10085292, ECO:0000269|PubMe... | null | null | null | null | null | FUNCTION: Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos (PubMed:16971515). Required for default nucleus positioning in oocytes (PubMed:16971515). {ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:15866166, ECO:0000269|PubMed:16054029, ECO:0000269|Pub... | Caenorhabditis elegans |
G5EEM6 | TAB1_CAEEL | MGDDGFLDQYPANTDAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFENVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFARKHRDAYTMSDDKNFCISNHREEM... | null | null | endodermal cell fate specification [GO:0001714]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of stress-activated MAPK cascade [GO:0032873] | cytosol [GO:0005829]; nucleus [GO:0005634] | mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase activator activity [GO:0030295]; protein serine/threonine phosphatase activity [GO:0004722] | PF00481; | 3.60.40.10; | null | null | null | null | null | null | null | null | FUNCTION: Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. {ECO:0000269|PubMed:10391246, ECO:0000269|PubMed:11323434}. | Caenorhabditis elegans |
G5EEM9 | PLA1_CAEEL | MSGSEEEHLVSLTFRKNEEDMDEDEGKVKQKEKPKEKQMEFVNQNFVESTEDESEVSTPTAVGLPIGTSTPDGDETPTQPDPNGKYTMAQTKDADLSRPSGLPSNGNPGSSTTVPPASKSGPVAPPRPSGTPVAPQRNRRRKVTELKCSEVRWFFQEPKGTLWNPFNGRDSIMLEIKYRKEKGIELDEAMQEIYDESLTHYKMEMKDEPEIENGNIGMEQEKPMVVVMNGQYKVNKDNSKIDPIYWKDDSKEIRRGSWFSPDYQPLEMPLSDQIEKNHLQCFRNQMIPEGTTVFSKSETSNKPVLAELHVDGYDIRWSSV... | 3.1.1.111; 3.1.1.4 | null | phosphatidylcholine catabolic process [GO:0034638]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; regulation of asymmetric cell division [GO:0009786]; regulation of protein localization [GO:0032880] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; phosphatase complex [GO:1903293] | calcium-independent phospholipase A2 activity [GO:0047499]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:00... | PF02862; | null | PA-PLA1 family | null | null | CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:66708, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72835, ChEBI:CHEBI:167448; Evidence={ECO:0000305|PubMed:2... | null | null | null | null | FUNCTION: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids, being phosphatidylinositol (PI) its major substrate. PI is a versatile lipid that not only serves as a structural component of cellular membranes, but also plays important roles in signal transduction... | Caenorhabditis elegans |
G5EEN4 | GCK3_CAEEL | MSSSNLAGNTNTTTTSSAASAAAAHSAANASTITSEYSTTQTTTGTFNTDTLSSIGSTSTLHGSQPSQPPPPPPPQVSSPIAAAAAASAALVAQLNPADRWPTEPSAYKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTA... | 2.7.11.1 | null | cell differentiation [GO:0030154]; epithelial tube morphogenesis [GO:0060562]; hyperosmotic response [GO:0006972]; meiotic cell cycle [GO:0051321]; multicellular organismal-level water homeostasis [GO:0050891]; phosphorylation [GO:0016310]; positive regulation of gene expression [GO:0010628]; spermatogenesis [GO:000728... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF12202;PF00069; | 1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily | PTM: Phosphorylated at Thr-280 and Ser-419 probably by wnk-1; phosphorylation results in weak activation (PubMed:18049475). Predominantly autophosphorylated at Thr-32 and Ser-190 and weakly autophosphorylated at Thr-13 and Ser-405 in vitro (PubMed:20595048). {ECO:0000269|PubMed:18049475, ECO:0000269|PubMed:20595048}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20595048}. Nucleus {ECO:0000269|PubMed:20595048}. Note=Localizes in the nucleus in intestinal cells. {ECO:0000269|PubMed:20595048}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:18049475, ECO:000026... | null | null | null | null | FUNCTION: Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation-mediated inhibition of the chloride channel clh-3 (PubMed:15684092, PubMed:17596296). In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1 (PubMed:... | Caenorhabditis elegans |
G5EEQ5 | REF1_CAEEL | MVLISTPPPAYAHNRKTSQEKKRRDEINAKIKELQLLIQNESDNEKMTQGDVLNRAVEVVSRMETESPGPSSNPNRKGFFDGFRSIESLTYSFIKSLGVNSDVCQDFVQRAKQFFDRERSSLLSTVSGKSKRRSESEILHSSMSYRSQSSSPSTSESGITIDRKEVKKNREQDRRDRQGEAFDALKNFIIENKLMTSHQVEKMQRLNTLDIIIAYIQNKKHNFVSRSDQEQSLYAHAIAEGKKTAKNIAFQFFKSDRHLVVRCADLEKFFEFSLSPKPLFGFPSMPIPIPPPSFPIFPFRPFPFFPMPMAPMATSPKSQQ... | null | null | anterior/posterior pattern specification [GO:0009952]; epidermal cell fate specification [GO:0009957]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nematode male tail tip morphogenesis [GO:0045138]; neuron development [GO:0048666]; regulation of neurogenesis [GO:0050767]; regulation of transc... | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00010; | 4.10.280.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:16376329}. | null | null | null | null | null | FUNCTION: Probable transcription factor (PubMed:11311160, PubMed:15935776, PubMed:16376329). Binds 5'-TGCCACGTGTCCA-3' in vitro, probably via the E-box motif 5'-CA[TC][AG]TG-3' (PubMed:15935776). Acts in embryonic development in a Notch-dependent manner, perhaps as a direct target of transcriptional regulator lag-1 in ... | Caenorhabditis elegans |
G5EET5 | CBXH1_CAEEL | MSRQNPVRSTRGNSLRAREAQQAQDAPLFQESSSNVFVVEKVLNKRLTRGGSEYYIKWQGFPESECSWEPIENLQCDRMIQEYEKEAAKRTTRKRRYSPQPSTSSSAELQPSTSDEWAGKTLKTIIGITKAPGELHFLCKFSDDSVHLIPLREANVRFPSQVIKFYETRLVLQGVSPTIPGGMS | null | null | chromatin organization [GO:0006325]; germ cell development [GO:0007281]; gonad development [GO:0008406]; negative regulation of gene expression [GO:0010629]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation o... | heterochromatin [GO:0000792]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] | chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; methylated histone binding [GO:0035064] | PF00385;PF01393; | 2.40.50.40; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16905130, ECO:0000269|PubMed:26476455}. Note=Partially co-localizes with histone H3 tails methylated at 'Lys-9' (H3K9me3) and 'Lys-23'(H3K23me2) in chromatin (PubMed:26476455). Localizes to distinct nuclear foci, not overlapping significantly with hpl-2, in embryonic ce... | null | null | null | null | null | FUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes (By similarity). Involved in epigenetic repression (By similarity). Probably does not act as global transcriptional repressor (PubMed:23028351). Plays a role in linking epigenetic regulation with the innate immune response (Pu... | Caenorhabditis elegans |
G5EET6 | EFA6_CAEEL | MAKVASSGAEEALATIDGAPRRNVKKSEAFVMSGDVLISLNRNVSSTYAKLLGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKLSRLPVPVSTSQIERRGSLARKTSEESSPTAIRMLKTAPIERMESTDVEESEEETVMMTTDEKENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIVAKSLRSAMFTMPTDNHHHSYNSSPQISTLSPHLRSNGDGPSRSPVYDDVDDDLNGSLDAKDMSNNSHQQSFRSPENYSEKDTPSKHSVVTIDGSGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRK... | null | null | microtubule depolymerization [GO:0007019]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of axon regeneration [GO:0048681]; negative regulation of mitotic spindle elongation [GO:1902845]; regulation of ARF protein sign... | cell cortex [GO:0005938]; microtubule minus-end [GO:0036449]; plasma membrane [GO:0005886] | guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] | PF15410;PF01369; | 1.10.1000.11;2.30.29.30; | null | null | SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:17676955, ECO:0000269|PubMed:21076413, ECO:0000269|PubMed:26339988}. Cell membrane {ECO:0000269|PubMed:26339988}. Note=Present throughout the embryonic cortex during the first embryonic mitosis, but at reduced levels in the posterior cortex (PubMed:210764... | null | null | null | null | null | FUNCTION: Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes (PubMed:21943602, PubMed:26339988). Limits microtubule growth near the cellular cortex o... | Caenorhabditis elegans |
G5EEU2 | SET25_CAEEL | MLPAWGTSTEATASHAGWDGDDEGDIRAAYTEDEKKENIPPISLTSVSTNGAYPGQKRRRSESVRTLKPECPPEETQRLRQRRRISATDATQSSRTMNVIEDRKPRVNRARKSQDAPSTSTCGFETPVGTKRKSKAADSQKPPKQSKLRKIDEASTSKAVDNSSKDGKKTTKPAVTQSNRRRSGLSLRPVPIETIFSESSGRESSTEDEADVSHQQRVEKIAKNPIMVVVLPLGPGNYPNNERITVVSTYKSRVNKNCNEARRAQRHGSWSRKGIAFPGIPTKKFTKSDLAKYGAHASNWPAQAAFRSEEGKILIYYEGW... | 2.1.1.-; 2.1.1.366 | null | methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814] | heterochromatin [GO:0000792]; nuclear lamina [GO:0005652] | double-stranded DNA binding [GO:0003690]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872] | PF00856; | 2.170.270.10; | Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22939621}. Chromosome {ECO:0000269|PubMed:22939621}. Nucleus lamina {ECO:0000269|PubMed:22939621}. Note=Colocalizes with its own product and hpl-1 in foci in the peripheral region of the nucleus, in a manner dependent on H3K9me3. {ECO:0000269|PubMed:22939621}. | CATALYTIC ACTIVITY: Reaction=N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60284, Rhea:RHEA-COMP:15541, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:... | null | null | null | null | FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate (PubMed:22939621, PubMed:28428426). Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina (PubMed:22939621). Required for small-RNA... | Caenorhabditis elegans |
G5EEU3 | AEX1_CAEEL | MREEALESICAALSISFTEDPDHLESIIDRFSEIFKVKDHLNQLRKKCEKFQTFTLEIRPVGSSNCTENVYAYIIESETCRQLELKPTGTTKLEIGSDKNVSLKFGLSQKKDSTTSKKGLSRSASLLKKLKFSDKKNLDELKISIFPLDIAVRKNINLGSGKSTLLEMKLIRNDHRNMIQCLEFDDFLEMTRSFHEWQAQISESELYDGSLGDPTFSMFYSIAFFFEIPSFVLKLTEMTCFLVWDDEMKKLDERALADVSLKMTACESEVDLQHPLLSPALSYLNDCTCNTIRCILVPFSTEPFFPPVSPSRLKSINVAL... | null | null | defecation [GO:0030421]; egg-laying behavior [GO:0018991]; exocytosis [GO:0006887]; lipid transport involved in lipid storage [GO:0010877]; locomotion [GO:0040011]; male mating behavior [GO:0060179]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of defecation [GO:20... | exocytic vesicle [GO:0070382]; secretory vesicle [GO:0099503] | null | PF00168; | 2.60.40.150; | Unc-13 family | null | null | null | null | null | null | null | FUNCTION: Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells (PubMed:11804572, PubMed:19028454, PubMed:2323555). Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle ... | Caenorhabditis elegans |
G5EEV2 | TRR1_CAEEL | MDPAMASPGYRSVQSDRSNHLTELETRIQNLADNSQRDDVKLKMLQEIWSTIENHFTLSSHEKVVERLILSFLQVFCNTSPQFIAENNTQQLRKLMLEIILRLSNVEAMKHHSKEIIKQMMRLITVENEENANLAIKIVTDQGRSTGKMQYCGEVSQIMVSFKTMVIDLTASGRAGDMFNIKEHKAPPSTSSDEQVITEYLKTCYYQQTVLLNGTEGKPPLKYNMIPSAHQSTKVLLEVPYLVIFFYQHFKTAIQTEALDFMRLGLDFLNVRVPDEDKLKTNQIITDDFVSAQSRFLSFVNIMAKIPAFMDLIMQNGPLL... | null | null | cell differentiation [GO:0030154]; DNA repair [GO:0006281]; negative regulation of vulval development [GO:0040027]; positive regulation of growth rate [GO:0040010]; regulation of DNA-templated transcription [GO:0006355]; reproduction [GO:0000003]; spermatogenesis [GO:0007283] | condensed chromosome [GO:0000793]; histone acetyltransferase complex [GO:0000123]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; SAGA complex [GO:0000124] | null | PF02259;PF20175;PF20206; | null | PI3/PI4-kinase family, TRA1 subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15068795}. Chromosome {ECO:0000269|PubMed:15068795}. Note=Localized to condensed chromosomes during pachytene and diakinesis stages of meiosis I in germ cells. {ECO:0000269|PubMed:15068795}. | null | null | null | null | null | FUNCTION: Influences germ cell fate in hermaphrodites (PubMed:24098152). Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote exp... | Caenorhabditis elegans |
G5EEV9 | SID2_CAEEL | MPRFVYFCFALIALLPISWTMDGILITDVEIHVDVCQISCKASNTASLLINDAPFTPMCNSAGDQIFFTYNGTAAISDLKNVTFILEVTTDTKNCTFTANYTGYFTPDPKSKPFQLGFASATLNRDMGKVTKTIMEDSGEMVEQDFSNSSAVPTPASTTPLPQSTVAHLTIAYVHLQYEETKTVVNKNGGAVAVAVIEGIALIAILAFLGYRTMVNHKLQNSTRTNGLYGYDNNNSSRITVPDAMRMSDIPPPRDPMYASPPTPLSQPTPARNTVMTTQELVVPTANSSAAQPSTTSNGQFNDPFATLESW | null | null | endocytosis [GO:0006897]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA transport [GO:0050658] | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | null | null | null | null | null | SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17381285, ECO:0000269|PubMed:17563372, ECO:0000269|PubMed:22902558}; Single-pass type I membrane protein {ECO:0000269|PubMed:17381285, ECO:0000269|PubMed:17563372, ECO:0000269|PubMed:22902558}. Cytoplasm {ECO:0000269|PubMed:17381285, ECO:0000269|PubMed:1756... | null | null | null | null | null | FUNCTION: Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria... | Caenorhabditis elegans |
G5EEW6 | SIG7_CAEEL | MAVLIETTLGDLIIDLFVKERPRCSLNFLKLCKKKYYNLNQFHSIERNYVAQTGDPTGTGKGGESVYSDMYGEQGRYFEREDLPKMRHTRMGIVSFVNNGDNMLGSQFFITLGENLDYLDDQHTIFGQVTEGLETLEKLNEQLADTNNRPFKDIRISHTIVLDDPFDEDARISFPPRSPSPTYEMLVKTDQIALDEKEDEDEGKTAEEIAEELQQREMAEQAQILEMVGDLKDADEVPPENVLFVCKLNPVTTDEDLEIIFSRFGKINNCEIVRDRRSGDSLQYAFIEFDNAKSCEQAFFKMDNVLIDDRRIHVDFSQSV... | 5.2.1.8 | null | nematode larval development [GO:0002119]; positive regulation of gastrulation [GO:2000543]; positive regulation of oocyte development [GO:0060282]; positive regulation of vulval development [GO:0040026]; transcription elongation-coupled chromatin remodeling [GO:0140673] | euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] | PF00160;PF00076; | 3.30.70.330;2.40.100.10; | Cyclophilin-type PPIase family, PPIL4 subfamily | null | SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:27541139}. Chromosome {ECO:0000269|PubMed:27541139}. Note=Co-localizes with transcriptionally active chromatin in all autosomes of mitotic and meiotic nuclei in germ cells. In transcriptionally inactive diakinetic oocytes, diffusely localized in the nucleop... | CATALYTIC ACTIVITY: Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000250|UniProtKB:Q08752}; | null | null | null | null | FUNCTION: Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-tr... | Caenorhabditis elegans |
G5EF15 | POS1_CAEEL | MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKETQNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCRFAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGAHANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYNSTAQLAQYFESQFQRIQQLSSHHH | null | null | cell fate specification [GO:0001708]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic pattern specification [GO:0009880]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of translation [GO:0006417] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; P granule [GO:0043186] | metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(U) RNA binding [GO:0008266]; single-stranded RNA binding [GO:0003727]; transcription corepressor activity [GO:0003714] | PF00642; | 6.10.250.3220;4.10.1000.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9834181}. Note=Localized to P granules in the germline blastomeres P1, P2, P3 and P4. {ECO:0000269|PubMed:9834181}. | null | null | null | null | null | FUNCTION: RNA-binding protein that coordinates cell fate specification and differentiation during early embryogenesis (PubMed:23034181, PubMed:9834181). Binds to a consensus pos-1 recognition element (PRE) consisting of the sequence 5'-UA(U 2-3)RGD(N 1-3)G-3', where R is any purine, D is A, G, or U, and N is any base (... | Caenorhabditis elegans |
G5EF33 | MIG13_CAEEL | MTKLLIALILFSICWKPYSAEPIASFFDGLDSRNECKARLDRRLTGFSGLLYSHSKYGQEPYNTSRNCVLMLVAPIGYSIRVRALQFDVASTENARTCEKDTLHVFDHETTLDPESYAPARIDDITSPGPIIGQFCGHFENRILNTSSHNALTLWWHSNPNGSNSKGFKLHWGSFRVSKTGNCVTGEFSCGNGECIPIESACDRFADCSNGEDLIHSRQMAANCQNIELDPLTTVSGVFVLLFSATIILSLCGFIMFVCCLCKCLKSTIPIKGASSHTTTTTATDYKPDPPQFYPPSPPKMPPPSAASSYTPRLHHHFEG... | null | null | positive regulation of cell migration [GO:0030335] | axon [GO:0030424]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] | null | PF00431;PF00057; | 4.10.400.10;2.60.120.290; | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10412978, ECO:0000269|PubMed:23784779, ECO:0000269|PubMed:27780040}; Single-pass type I membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:10412978}. Cell projection, axon {ECO:0000269|PubMed:10412978, ECO:0000269|PubMed:26762178}. Cell projection, den... | null | null | null | null | null | FUNCTION: Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development (PubMed:10412978, PubMed:1575018... | Caenorhabditis elegans |
G5EF48 | FLD1_CAEEL | MRQLAELLTDLLGPVPTMFLWVIVSFAFFRALQFIVRWYLFGKWTWPNFNFFDIRNRIRRRRRGGQEAENTENPPENEAEAGEQVEQEPEPDSRDLSAIPPNKKWRISNECVSLFHSVISGLWAAYALLYYKQLVQDLVNYRCDVAINLVLMSAGYLFHDLVDLLVNEQSARIIELLFHHVVVLSAFAVTMFFNRFLGVVVFGLLMELNSIFLHSRSLLNLYGVDKKSPSFRIIALLNMVTLFAFRLCVSAYLVYFVVVSIPDLEWYVSIINGLVIASLASTNTVLTYRLLAADGLLGSRRTRRTPAATAETQVGDVESG... | null | null | membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035] | plasma membrane [GO:0005886] | null | PF03798; | null | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30509349}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LC... | Caenorhabditis elegans |
G5EF53 | SWSN4_CAEEL | MSGRPAFEQFTAQPPQPAGEVVAQQAGDGAQGQELTISKLENAITSMEEQGLQNDHRHAKAVLLKQKLQSGLPDAVPGQENGGNQQITPAQLNQLRAQVSAYRLLARNEQVPANLIADAVMLRPKVTTLLPEPYEYPGEAENGEKLPYDLMKIFNLHQIRCNRPTTISVPSGIDPVGMLKQRENMIQNRIGLRMKLLNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSEVMACLKRDTTLETALNPYAYRRTKRQSLREARVTEKLEKQQKMEQERKRRQKHTDLMQAIIQHGKEFKEYHRNNLLKMAKSRKAVMTYH... | 3.6.4.- | null | chromatin remodeling [GO:0006338]; gonad development [GO:0008406]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition... | nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] | ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787] | PF07533;PF00439;PF00271;PF07529;PF08880;PF00176; | 1.20.5.170;3.40.5.120;1.20.920.10;3.40.50.300;3.40.50.10810; | SNF2/RAD54 helicase family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11030341, ECO:0000269|PubMed:27207389}. | null | null | null | null | null | FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) (By similarity). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts with... | Caenorhabditis elegans |
G5EF60 | STIM1_CAEEL | MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAI... | null | null | intracellular calcium ion homeostasis [GO:0006874]; ovulation [GO:0030728]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of smooth muscle contraction [GO:0045987]; reproduction [GO:0000003]; store-operated calcium entry [GO:0002115] | cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; intracellular organelle [GO:0043229]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] | calcium channel activity [GO:0005262]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] | PF07647;PF16533; | 1.10.238.180;1.10.287.3550;1.10.150.50; | null | null | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}; Single-pass type I membrane protein {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}. Note=Localizes to intracellular puncta in the anterior intestine and reticular structure in the posterior intestine. {ECO:0000269|Pub... | null | null | null | null | null | FUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as a Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contracti... | Caenorhabditis elegans |
G5EF76 | LIN22_CAEEL | MTSFLCSDTEIESDGGISRCKKIKNKPLMEKKRRARINKSLSQLKQILIQDEHKNSIQHSKWEKADILEMAVEYLQQLRSAQPCSLSPSTSSISTPPTPKEEIRNIKVPLNPIASFLNPMMQQYVAYQQLAQLSMYTQLFNNPAGVPLRADAGVTAQSPELAEKLKIEDRSRV | null | null | anterior/posterior pattern specification [GO:0009952]; epidermal cell fate specification [GO:0009957]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron differentiation [GO:0045665]; nematode male tail tip morphogenesis [GO:0045138]; Notch signaling pathway [GO:0007219]; regulation of n... | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; N-box binding [GO:0071820]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00010; | 4.10.280.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. | null | null | null | null | null | FUNCTION: Probable transcription factor (PubMed:29108019, PubMed:9247331). During development, required for cell fate specification, probably by promoting or repressing expression of genes involved in specific cell fate (PubMed:29108019, PubMed:9247331). Involved in specifying lineages derived from the epidermal stem c... | Caenorhabditis elegans |
G5EF96 | UNC40_CAEEL | MILRHFGFILIILTVYLSSTHATTRKHHRRSIDNDARNLGFQFVMEPRRNVTVMESSSHLLECSYVLAHERLVHDVRIEWKRDGVLLSERTSSRIKVMSNGSLWIESVSSAEEGTYQCAVHVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAIDRTLAKGQPTAFHCLINSKPTPTAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGTYRCTVEGAGKRRSSQTARLTVTTETVSNELVFITTPRLQVVEQGDEFLLECLVASLIRPQVRWLKDSRQIIVDGVRIRRVGVSSILVSRASIEDTGLYTCRASNN... | null | null | axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell projection morphogenesis [GO:0048858]; cell-cell adhesion [GO:0098609]; chemorepulsion of axon [GO:0061643]; dendrite morphogenesis [GO:0048813]; determination of left/right asymmetry in nervous system [... | axonal growth cone [GO:0044295]; cell projection membrane [GO:0031253]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | cell-cell adhesion mediator activity [GO:0098632]; netrin receptor activity [GO:0005042]; protein domain specific binding [GO:0019904] | PF00041;PF07679;PF13927; | 2.60.40.10; | Immunoglobulin superfamily, DCC family | null | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. | null | null | null | null | null | FUNCTION: Receptor for netrin unc-6 required for asymmetric axon formation, axon guidance and cell migrations (PubMed:11454756, PubMed:16520734, PubMed:22426253, PubMed:8861903, PubMed:9473333). Required during axon formation, in response to unc-6, to initiate, maintain and orient asymmetric neuronal growth, and may si... | Caenorhabditis elegans |
G5EFA2 | BIR1_CAEEL | MAPGTKKKSDMAKFTFYKDRLMTFKNFEYDRDPDAKCTSQAVAQAGFYCTGPQSGKCAFCNKELDFDPEDDPWYEHTKRDEPCEFVRIGKLDDSELTINDTVRLSQTAMIMTKLFEHEMMINNLSNHSSSDALFDQLKKVPNTASTTKSNSRRGK | null | null | chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; egg-laying behavior [GO:0018991]; inductive cell migration [GO:0040039]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of mi... | chromosome passenger complex [GO:0032133]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; spindle midzone [GO:0051233] | metal ion binding [GO:0046872] | PF00653; | null | IAP family | null | SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:10983970}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10983970}. Midbody {ECO:0000269|PubMed:10983970}. Note=In mitosis and meiosis, localizes to chromosomes during prometaphase and metaphase, localizes to both chromosomes and the spindle midzone during ana... | null | null | null | null | null | FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:10209096, PubMed:10983970, PubMed:12707312). The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segre... | Caenorhabditis elegans |
G5EFC3 | KCNAG_CAEEL | MLDACSFNRFDSNRSSARRFSRRGSDYFGDKGISMDERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGKLHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADHEDDPQLREQDTMKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIFSFCLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLELIIRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPK... | null | null | monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] | axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] | delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244] | PF02214;PF00520; | 1.10.287.70;1.20.120.350; | Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Shaw sub-subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P08510}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08510}. | null | null | null | null | null | FUNCTION: Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. {ECO:0000269|PubMed:9247271, ECO:0000269|PubMed:9247272}. | Caenorhabditis elegans |
G5EFD2 | KSRA_CAEEL | MMQTQVASRAGYSNLPQFGAGIAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKIFSAVYQMTKIGLIDREKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSGSTDEPSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSSSMGFATTPKSPKTSSRLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDHLRFLFDKLIQENNGGMWKDPQSVPGSRSMNEPAFQFPDTAIDSSS... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305}; | cell fate specification [GO:0001708]; defense response to Gram-positive bacterium [GO:0050830]; meiotic cell cycle [GO:0051321]; myoblast migration [GO:0051451]; nematode larval development [GO:0002119]; phosphorylation [GO:0016310]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulati... | cytoplasm [GO:0005737] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | PF07714; | 3.30.60.20;1.10.510.10; | Protein kinase superfamily, TKL Ser/Thr protein kinase family | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000305}; CATALYTIC ACTIVITY: React... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration (PubMed:11882296, PubMed:8521513). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swell... | Caenorhabditis elegans |
G5EFD4 | HMT1_CAEEL | MGFSPFLDECRAEGLWPIGPSCNKIISFGVYTFFIVVNFIVLCIPNSNSANNNYRRMTDDDASSTSKLTISKILSICTIFAVICQSIFYFCFTFYFHPYTHLLLAFCVSKLFFWILSLCSFSKWRNQPSTPISLAFAFSAALLIHCIPLTDWKKYFEPTSKNRGDLTFYIIELALVTVVFFFTIVTGLFNFSGCSSRESAWNNLSKKVVTVAPYIWPTKSISLQLRVVFCLFLLIIGRLINVSLPILSKWIVDELATPDTFQYSLLFLATFLKFLQGNGAMGGFLNTVRTYLWIPIQQYTTRELEVELFKHLHSLSLRWH... | null | null | cadmium ion transmembrane transport [GO:0070574]; cellular detoxification of cadmium ion [GO:0098849]; detoxification of cadmium ion [GO:0071585]; detoxification of copper ion [GO:0010273]; heme transport [GO:0015886]; response to cadmium ion [GO:0046686]; transmembrane transport [GO:0055085] | early endosome [GO:0005769]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; vacuolar membrane [GO:0005774] | ABC-type heme transporter activity [GO:0015439]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadmium ion transmembrane transporter activity [GO:0015086]; heme binding [GO:0020037] | PF00664;PF00005; | 1.20.1560.10;3.40.50.300; | ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3.A.1.210) subfamily | null | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:15840570}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31053883}. Late endosome {ECO:0000269|PubMed:31053883}. Recycling endosome {ECO:0000269|PubMed:31053883}. | null | null | null | null | null | FUNCTION: May play a pivotal role in the detoxification of heavy metals such as cadmium but do not depend exclusively on phytochelatins (PC) synthesis. {ECO:0000269|PubMed:15840570, ECO:0000269|PubMed:31053883}. | Caenorhabditis elegans |
G5EFD5 | UNC71_CAEEL | MICASKITMLGLLVMCTLGGVLGKVDIRQTTANKAFMETMRADGYEVVHPFQIRDKNERIGIDTRNYFLKAQEHYSHVTIVIRSNQLGRLKLVLERNNFIFLNQTAFHKLDADGERVIQNRVENCYYQGTVGGEESSFVALSSCNGLRGVISFANGTTFGIWPLDGGDRNSRRHPHILYKSEWSQEAKCGSSMAHAVGQRRMKKHVHKHRSHHHEHNKKRDVSKRTKYVEVALIADYEFMKARGLHDLDAISYMLESLNIADSMLSRDLNIRLSAVYVELWTDVQRIDLWEDIERTLSGVVDYASGHIYHIQKDASILFT... | null | null | cell-cell adhesion [GO:0098609]; membrane protein ectodomain proteolysis [GO:0006509]; plasma membrane fusion [GO:0045026]; proteolysis [GO:0006508] | membrane [GO:0016020]; plasma membrane [GO:0005886] | metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] | PF08516;PF00200;PF07974;PF01421; | 3.40.390.10;4.10.70.10;2.10.25.10; | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12783787, ECO:0000305|PubMed:8970152}; Single-pass type I membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development (PubMed:12783787, PubMed:22293500, PubMed:9073451). Involved in axon branching and guidance of neurons including GABAergic type D motor neurons (PubMed:12783787). Promotes sex ... | Caenorhabditis elegans |
G5EFD9 | ADA10_CAEEL | MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRA... | 3.4.24.81 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P78325}; Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:P78325}; | cell fate specification [GO:0001708]; embryo development ending in birth or egg hatching [GO:0009792]; membrane protein ectodomain proteolysis [GO:0006509]; nematode male tail tip morphogenesis [GO:0045138]; Notch signaling pathway [GO:0007219]; positive regulation of transforming growth factor beta receptor signaling ... | basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] | PF21299;PF13574; | 3.40.390.10;4.10.70.10; | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28068334}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:28068334}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28068334}; Single-pass type I membrane protei... | CATALYTIC ACTIVITY: Reaction=Endopeptidase of broad specificity.; EC=3.4.24.81; Evidence={ECO:0000250|UniProtKB:O14672}; | null | null | null | null | FUNCTION: Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification (PubMed:16197940, PubMed:9409830... | Caenorhabditis elegans |
G5EFE7 | FUT8_CAEEL | MLKCIAAVGTVVWMTMFLFLYSQLSNNQSGGDSIRAWRQTKEAIDKLQEQNEDLKSILEKERQERNDQHKKIMEQSHQLPPNPENPSLPKPEPVKEIISKPSILGPVQQEVQKRMLDDRIREMFYLLHSQTIENSTKILLETQMISLMGLSAQLEKLEGSEEERFKQRTAITQRIFKSIEKLQNPKACSEAKTLVCNLDKECGFGCQLHHVTYCAITAFATQRMMVLKRDGSSWKYSSHGWTSVFKKLSKCSFDEAVGNTEAKPFAEPSPARVVSLGIVDSLITKPTFLPQAVPEQLLESLTSLHSHPPAFFVGTFISYL... | 2.4.1.68 | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:15604090}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15604090}; Note=May also use Ca(2+). The enzyme has substantial activity without divalent cations. {ECO:0000269|PubMed:15604090}; | fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]; protein N-linked glycosylation [GO:0006487] | Golgi cisterna membrane [GO:0032580] | alpha-(1->6)-fucosyltransferase activity [GO:0046921]; fucosyltransferase activity [GO:0008417]; galactoside 6-L-fucosyltransferase activity [GO:0046702]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]; metal ion binding [GO:0046872] | PF19745; | 3.40.50.11350;2.30.30.40; | Glycosyltransferase 23 family | null | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000255|PIRNR:PIRNR000472}; Single-pass type II membrane protein {ECO:0000305}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-be... | null | PATHWAY: Protein modification; protein glycosylation. {ECO:0000255|PIRNR:PIRNR000472}. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6-7.5. {ECO:0000269|PubMed:15604090}; | null | FUNCTION: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:15604090). The addition is prevented if the GlcNAc residue is already fucosylated (PubMed:15604090). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely ... | Caenorhabditis elegans |
G5EFF1 | ASD2_CAEEL | MDCDNGVVSEISDDKELLNLETVIPPPPNDSGHEFIGPSSGPPQVTITPSGVQSGSANGVSTSQQQQYSAEYLSQLLKDKKQLAAFPNVFHHLERLADEEINKVRVVLFQCEFSKESAPLPDAEGDSTVHTEKVFVPAKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEELNRGKPNWEHLSEELHVLIQCEDTENRAKVKLMRAVEEVRKLLVPAPEGEDDLKRKQLMELAIINGTYRSGTDQSALAAAQLAAVKHQQQPFAAALQAAALQRGVLPMMANGLSRSPTMAVCGAPIVMSPSGRASS... | null | null | mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380] | nucleus [GO:0005634]; P granule [GO:0043186]; ribonucleoprotein complex [GO:1990904] | mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; single-stranded RNA binding [GO:0003727] | PF00013;PF16544; | 1.20.5.4010;3.30.1370.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23071450}. | null | null | null | null | null | FUNCTION: RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)-UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing (PubMed:18230701, PubMed:20573244, PubMed:23071450). Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons durin... | Caenorhabditis elegans |
G5EFF4 | SEM4_CAEEL | MNELLAEMAAVSSRRKQSKPRRMSGEGDAMMSPIDLSTKSFDENNCEKGAGGALPLEDRSNILPHFSVPFANPQQFLSLCAQLGNSSSRNVSSTASTTSSCPIQSCSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFSNGQDIREHKCQKTLASRSTSVPPSTIPSSVCFLSTPTTPCLQFSINESIGTSEIREEDEEEDMDVEDGEHVANQLFGHLLQKSDDKSKMASLFNHAFPPFAAFPNMPPPFLMRQPFDPRADVFAAGRHDNDDDWEALMEISTSDEAEKIRALVGDKAVPTTDPNQCILCRRVLSCKSAL... | null | null | mesodermal cell differentiation [GO:0048333]; muscle cell differentiation [GO:0042692]; myoblast fate specification [GO:0048626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; positive regulation of gene expression [GO:0010628]; positive regulation of t... | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | PF00096;PF12874; | 3.30.160.60; | Sal C2H2-type zinc-finger protein family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | null | null | null | null | null | FUNCTION: Transcription factor, involved in positive and negative modulation of transcription (PubMed:12835398, PubMed:28614700). Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3 (PubMed:12835398). Involved in cell-fate regulation... | Caenorhabditis elegans |
G5EFF5 | DAF12_CAEEL | MGTNGGVIAEQSMEIETNENPDKVEEPVVRRKRVTRRRHRRIHSKNNCLTPPNSDDDPQMSTPDDPVIHSPPSIGAAPGMNGYHGSGVKLEESSGACGSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPGNQQSPQGPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGAQPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHR... | null | null | cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; heat acclimation [GO:0010286]; male mating behavior [GO:0060179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dauer larval d... | nucleus [GO:0005634] | (25S)-Delta(4)-dafachronate binding [GO:1902051]; (25S)-Delta(7)-dafachronate binding [GO:1902052]; DNA-binding transcription factor activity [GO:0003700]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:004356... | PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10859169, ECO:0000269|PubMed:15611047, ECO:0000269|PubMed:23990780}. Note=Diffuse expression during mitosis (PubMed:10859169). Increased nuclear accumulation upon infection by E.coli (PubMed:23990780). {ECO:0000269|PubMed:10859169, ... | null | null | null | null | null | FUNCTION: Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:10859169, PubMed:15314028, PubMed:15383841, PubMed:15489294, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518, PubMed:9477318). Activity is modulated by binding of steroid hormone ligands that include... | Caenorhabditis elegans |
G5EFH8 | CBS1_CAEEL | MIQNEVSATHGSTKKGITYNTILEAAQRPTPLVPLKKLKVEHQLQSDIYVKLEYLNIAGSLEDRTADKAFQFAEEIGVVRGDEVFVTAGGSAAISYATVAAVKGIKLTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQTDEAAQQKGVFSLNKFTTNAAFVANLQKTALEIEKAVNNKSIGKVGAVVIPLNTGAAAAGIAAYYKGIGEHGVRVVGVTCKKDTIPEMGLDLKNDLLQEYNVEKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLEAIKLAKELPAGSTIVVVLMDGIRNYLRHFLDDDWITANK... | 4.2.1.22 | COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250|UniProtKB:P35520}; | cysteine biosynthetic process from serine [GO:0006535]; sulfur compound biosynthetic process [GO:0044272] | cytoplasm [GO:0005737] | cystathionine beta-synthase activity [GO:0004122]; cysteine synthase activity [GO:0004124]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170] | PF00291; | 3.40.50.1100; | Cysteine synthase/cystathionine beta-synthase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22240119}. | CATALYTIC ACTIVITY: Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine; Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22; Evidence={ECO:0000269|PubMed:22240119}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5.57 mM for serine as substrate (at 16 degrees Celsius) {ECO:0000269|PubMed:22240119}; KM=4.29 mM for homocysteine as substrate (at 16 degrees Celsius) {ECO:0000269|PubMed:22240119}; Vmax=1.5 mmol/h/mg enzyme with serine as substrate (at pH 7.0 and 25 degrees Celsi... | PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. {ECO:0000250|UniProtKB:P35520}. | null | null | FUNCTION: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine (PubMed:22240119). Plays a role in maintaining homocysteine homeostasis (PubMed:2224011... | Caenorhabditis elegans |
G5EFI7 | MYRF1_CAEEL | MSSSDLLKGEFDGLNSEHFNMMQYLTQDTDEDDGSMVSPTSSADSMHQNLGVQQQQQQMLQAQQRQNQNGIFQPRRFPESPAMTDPCGNVSSSSSSSHHSDPMFSPNEFNGYAGANDNGNQTMNNIQSQQLSQQQHQQTRGGNLMMPQQSSIHAQMQNMNAPQFWSQPGTAAVNQPTNTLAQLNLFNIIRGGADSGMPSPVLEMPRKRSRLDTPCETPRIAPSFAGIDGFPDENYSQQQAIRFSKFQEEQWSPLYDINAQPLQQLQVHVVADKGFNYNSNDNCFVNQKKNHFQISVNVEASDTMPPKYVNFNNRLVPIRD... | 3.4.-.- | null | cell differentiation [GO:0030154]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; nematode larval development [GO:0002119]; positive regulation of DNA-templated transcription [GO:0045893]; protein autoprocessing [GO:0016540]; regulation of n... | apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | DNA-binding transcription factor activity [GO:0003700]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565] | PF13888;PF13887;PF05224;PF13884; | 1.10.10.10; | MRF family | PTM: Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity. {ECO:0000305|PubMed:28441531}. | SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28441531}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:33950834}. Apical cell membrane {ECO:0000269|PubMed:33950834}; Single-pass membrane protein {ECO:0000255}. Note=In early L1 la... | null | null | null | null | null | FUNCTION: [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor (PubMed:28441531). Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during ne... | Caenorhabditis elegans |
G5EFI8 | PLCE1_CAEEL | MNWDTLKGVLKTRRLTKRTIPAYIHPTSRSDSTSSTQSATAGFILNEEPITLFRLELERLQYILHFPEEVAFQLSSTEYQLFYSIQPMDYVRYVSCDLTSVPVSENPSPVRNLVKRLSEVSSWITHVIVSQPTHDDRKVALTAILRIVETCWNIGNFNAAVEVLMGLKSEKLRPFWLSLRQEEKSQFDSLCETLLPANQALPSQAYINAVQRALRMPQSRVIPFFGIFLRDLYAIVNDLPNIVVIGQEGETQKLEFMSDPNGEDHFSSRIGVGGLLNADKINLVAIVLDNLELFHRHSRTMIKLLEEQAVPPIQIPQNER... | 3.1.4.11 | COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:9497345}; | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process [GO:1902634]; activation of immune response [GO:0002253]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-media... | null | GTPase inhibitor activity [GO:0005095]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; small GTPase binding [GO:0031267] | PF00168;PF09279;PF00388;PF00387;PF00788;PF00617; | 2.60.40.150;1.10.238.10;3.20.20.190;1.10.840.10; | null | null | null | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence={EC... | null | null | null | null | FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9497345). plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras... | Caenorhabditis elegans |
G5EFJ4 | CAPG1_CAEEL | MPPKKRIRGPKLPALREEKSTGTDVASDESFNESADFLNNEELNNDQNDAENTVLSEGVSTLRINENMTKEDRACISAALFIKKRVVESIRTVFQSRDDINDEIHTSSRKLIAAFKKADQNRKKKVDLMKVFLDEIDVRLSMIIEEVTVPEHRARVFKLIAVTITEIQAFKLPSDLLDFIINFINTWGHSDNVAARINTTCFISYIFETGKRYLTTEGEYSGFEVKIAAKMFLQLKRALLDKEQTARVPAIRGLGFLQEIPIPSNWPVDAMKHSPRELLLRSCRDTAWECRLVAVQSMVPLETDVRLLSDIVYYDKCLNV... | null | null | cell division [GO:0051301]; dosage compensation by hypoactivation of X chromosome [GO:0042464]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic chromosome segregation [GO:0045132]; meiotic sister chromatid segregation [GO:0045144]; mitotic chromosome condensation [GO:0007076]; mitotic sister ch... | condensed chromosome [GO:0000793]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; dosage compensation complex [GO:0046536]; X chromosome [GO:0000805] | null | PF12719; | 1.25.10.10; | CND3 (condensin subunit 3) family | null | SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:23684975}. Note=During meiosis and mitosis, localizes to condensed chromosomes in both sexes (PubMed:19119011). Localizes to the spindle midzone in between separating chromosomes during anaphase and to the midbody during cytokinesis (PubM... | null | null | null | null | null | FUNCTION: Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex (PubMed:19119011, PubMed:19781752). The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in me... | Caenorhabditis elegans |
G5EFJ9 | UN103_CAEEL | MKTAVFGRDSGEPGSPCGAPPSLTFTPPATLVPPTHHHSRSTNRGGVSGTGGGGSGGLQGAPGAGGPRASHSSRRTSRLHNNVSALGVLSLGADVLPEYKLQPTRIHHCTIVHYSPFKAVWDWIILLLVIYTAVFTPYVAAFLLRELQDTAKKSRFTEPLEIVDLIVDIMFIVDIIINFRTTYVNENDEACQVVSDPGKIATHYFKGWFIIDMVAAVPFDLLLVSTNSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLLLLMATFALIAHWLACIWYAIGSAELSHKEYTWLHQLSKQLAQPYTSTNGTIPTGG... | null | null | mating behavior [GO:0007617]; membrane repolarization during action potential [GO:0086011]; potassium ion transmembrane transport [GO:0071805]; regulation of egg-laying behavior [GO:0046662]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937] | monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] | inward rectifier potassium channel activity [GO:0005242] | PF00027;PF00520; | 1.10.1200.260;1.10.287.70;2.60.120.10; | Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.1/KCNH2 sub-subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior (PubMed:12684455). {ECO:0000250|UniProtKB:Q12809,... | Caenorhabditis elegans |
G5EFL0 | GLD4_CAEEL | MNEDSRLSSSQQPSTSTPRSSIPSTMNSDEPNTCRRLSQSQEQPSTSRTCKSETPEFGYSDSLPFAPWRRKRYGLNIQGLHEEIVDMYHWIKPNEIESRLRTKVFEKVRDSVLRRWKQKTIKISMFGSLRTNLFLPTSDIDVLVECDDWVGTPGDWLAETARGLEADNIAESVMVYGGAFVPIVKMVDRDTRLSIDISFNTVQGVRAASYIAKVKEEFPLIEPLVLLLKQFLHYRNLNQTFTGGLSSYGLVLLLVNFFQLYALNMRSRTIYDRGVNLGHLLLRFLELYSLEFNFEEMGISPGQCCYIPKSASGARYGHKQ... | 2.7.7.19 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O17087}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:O17087}; | cytoplasmic polyadenylation [GO:0180011]; meiotic cell cycle [GO:0051321]; positive regulation of meiotic cell cycle [GO:0051446]; RNA 3'-end processing [GO:0031123] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; TRAMP complex [GO:0031499] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; poly(A) RNA polymerase activity [GO:1990817] | PF01909;PF03828; | 1.10.1410.10;3.30.460.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19339688}. Cytoplasmic granule {ECO:0000269|PubMed:19339688}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19339688}. Note=Localizes to P granules. This association is less apparent during pachytene, becomes obvious in maturing oocytes and is most prominently vis... | CATALYTIC ACTIVITY: Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence={ECO:0000269|PubMed:19339688}; | null | null | null | null | FUNCTION: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumu... | Caenorhabditis elegans |
G5EFM9 | NEKL3_CAEEL | MDKISNIYNFDDPPPDKLSLELFIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQLRDLVSRCILPEASKRPETSEVLQVAEHMNNYFSPSGDQSTTPSTQF | 2.7.11.34 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q9HC98}; | gonad development [GO:0008406]; molting cycle [GO:0042303]; multicellular organism growth [GO:0035264]; phosphorylation [GO:0016310] | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25523392}. Note=In hyp7 syncytium, localizes in puncta and small tubules near the plasma membrane apical region. Does not co-localize with nekl-2. {ECO:0000269|PubMed:25523392}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.34; Evidence={ECO:0000250|UniProtKB:Q9HC98}; CATALYT... | null | null | null | null | FUNCTION: Probable serine/threonine-protein kinase required for the completion of molting. {ECO:0000269|PubMed:25523392}. | Caenorhabditis elegans |
G5EFN6 | FLP2_CAEEL | MQVSGILSALFLVLLAVIVSPFQFVQPKRILPIPTSRDQLLRGQLAYLKGTTVAQPAVNDNTLGIFEASAMAKRLRGEPIRFGKRSPREPIRFGKRFNPLPDYDFQ | null | null | G protein-coupled receptor signaling pathway [GO:0007186]; locomotion [GO:0040011]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of protein secretion [GO:0050714]; signal transduction [GO:0007165]; sleep [GO:0030431] | null | null | null | null | null | null | null | null | null | null | null | null | FUNCTION: FMRFamide-like neuropeptides (PubMed:15809090, PubMed:24533288). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1 (PubMed:27585848). Inv... | Caenorhabditis elegans |
G5EFP5 | FUTC_CAEEL | MRVRPASVYRYLLLGVCALLGIYTVYSIIGYDDGSHVPIHRPQRHLYLTVSQDRIGSRFGKLAPKRILYWTTIFGATVPSTALSDCPGLTDRCVIDTNRHQLDSADAVVFHAADISKFPLPVSRKPDQIFVFNSMETPDNSGRFAVPDGFFNWTSTHLYSSDAIHKYGTFLIPTQIAESRGFKVQSYYVQPKRLVKTMKGIFGLISNCHTKSKRELALQELGKHINVTIGGKCASDDRLKSICPAGVECIDVFEQYPFYIAIENTVCNDYVTEKIWSRITVPSIPIVMRRRVYQNILPPKSFIAMDDYKNPSEMANHLRS... | 2.4.1.65 | COFACTOR: Note=Unlike other alpha-(1,3)-fucosyltransferases, appears not to require a divalent metal cation as cofactor. {ECO:0000269|PubMed:17369288}; | fucosylation [GO:0036065]; protein glycosylation [GO:0006486] | Golgi cisterna membrane [GO:0032580] | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060] | PF17039;PF00852; | 3.40.50.11660; | Glycosyltransferase 10 family | PTM: N-glycosylated. {ECO:0000269|PubMed:17369288}. | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}. | CATALYTIC ACTIVITY: Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:23628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:13350... | null | PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:17369288}. | null | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 23 degrees Celsius. Vey low activity at 37 degrees Celsius. {ECO:0000269|PubMed:17369288}; | FUNCTION: Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-al... | Caenorhabditis elegans |
G5EFQ0 | GCY18_CAEEL | MLKTLLFILIFFNIPIIAIEEIPDIKENGEKSSYTQFDNGAKLEVNKEHKRVIKIGHIGAVGVMPNDARILNISKENLIEEGLVGDDIEFEIVSRQACSESFEGVAVAAELYHVHQVRAFIGPYCAAELEAVTKMATFWNIPIISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALLLHYKWLKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGDLAANARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEMLQRVKDHYANAIIVDDVNGF... | 4.6.1.2 | null | cGMP biosynthetic process [GO:0006182]; detection of temperature stimulus [GO:0016048]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052] | cilium [GO:0005929]; microvillus membrane [GO:0031528]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886] | adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; metal ion binding [GO:0046872]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672] | PF01094;PF00211;PF07714; | 3.40.50.2300;3.30.70.1230;1.10.510.10; | Adenylyl cyclase class-4/guanylyl cyclase family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:16415369}. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons. {ECO:0000269|PubMed:16415369}. | CATALYTIC ACTIVITY: Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence={ECO:0000250|UniProtKB:Q19187}; | null | null | null | null | FUNCTION: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369). {ECO:0000250|UniProtKB:Q19187, ECO:0000269|PubMed:16415369... | Caenorhabditis elegans |
G5EFQ5 | RUNX1_CAEEL | MTNVFHHVRNFIEQQPAPAKTLEKSSSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDARIPKPQGSLKRQAEQQTIFPNDIIRTPGPPMPMTMIPPPWFPLPMTQTFPPSFFPLISPGPHPSISAALWKIHSESMKTPIKQKVEQENVSLNTSTCLSSPSIFITPTSDDRKLKRPSSPRSITKSSETSINLIQETPESVESKRRRNVSITSSNSSSPTIWRPF | null | null | asymmetric cell division [GO:0008356]; asymmetric stem cell division [GO:0098722]; chondrocyte differentiation [GO:0002062]; dopamine metabolic process [GO:0042417]; embryo development ending in birth or egg hatching [GO:0009792]; hemopoiesis [GO:0030097]; negative regulation of gene expression [GO:0010629]; negative r... | core-binding factor complex [GO:0016513]; nucleus [GO:0005634] | ATP binding [GO:0005524]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:00435... | PF00853; | 2.60.40.720; | null | PTM: May be ubiquitinated in order to be targeted for proteasome-mediated degradation in intestinal cells. {ECO:0000269|PubMed:22308034}.; PTM: May be phosphorylated by members of the p38 MAP kinase pathway. {ECO:0000269|PubMed:22308034}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399, ECO:0000269|PubMed:16226243, ECO:0000269|PubMed:16236764, ECO:0000269|PubMed:31740621}. Note=High level of nuclear localization in interphase seam cells before the symmetric larval stage L2 divisions, but subsequently rnt-1 disappears during mitosis, ... | null | null | null | null | null | FUNCTION: Transcription factor (By similarity). Binds to regulatory DNA sequences in order to modulate transcription; negatively autoregulates its own expression, perhaps dependent upon CBF beta homolog bro-1 (PubMed:18158917). Promotes proliferation, and prevents differentiation, of seam cells, a stem cell-like lineag... | Caenorhabditis elegans |
G5EFR6 | MCA1_CAEEL | MQKSQNVTAVTETNGVAAALGGHHTSPDTNAGKTKDAKEFGCSLGDLRGLMEARGAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTIPPAKSKGFVRLVLDACKDPTLVILVLSGFINLALSFYEPTSAAEDATQHLVNATTAAILANGTFMSTTEAPSEGHGTAWIEGVAILLCVIVVVLVTAVNDYSKERQFRSLQEKIETGQKFSVIRNGEAIDVPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDESSLTGESDHIKKSIESDPVLLSGTYAMEGSGKMLITAVGVNSQTGIIMTLL... | 7.2.2.10 | null | calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; regulation of cytosolic calcium ion concentration [GO:0051480] | intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388] | PF13246;PF00689;PF00690;PF00122;PF08282; | 3.40.1110.10;2.70.150.10;1.20.1110.10;3.40.50.1000; | Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23634}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361146}. | CATALYTIC ACTIVITY: Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence={ECO:0000255|RuleBase:RU361146}; | null | null | null | null | FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium across a membrane. {ECO:0000269|PubMed:9933625}. | Caenorhabditis elegans |
G5EFS2 | MSI1H_CAEEL | MTTTVSTGATAVATLRETSPPVDGHEEARLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRDPATKRARGFGFITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAKLVTKTKKVFIGGLSATSTLEDMKQYFETYGKVEDAMLMFDKATQRHRGFGFVTFDSDEVADKVCEIHFHEINGKMVECKKAQPKEVMLPVQLNKSRAAAARNLYGMPPETLLAYAQYLPRFGGNLMYPNFTNVFNNMPGGYSGLSTPGGSSNRPPHQFDTASLYSLNNGGQLLDSQAQMFMNQQSYHSHSKY | null | null | central nervous system development [GO:0007417]; nervous system process [GO:0050877]; regulation of translation [GO:0006417] | cytoplasm [GO:0005737]; perikaryon [GO:0043204] | mRNA binding [GO:0003729] | PF00076; | 3.30.70.330; | Musashi family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11122376}. Perikaryon {ECO:0000269|PubMed:11122376}. | null | null | null | null | null | FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level (PubMed:24630719). Binds RNA containing the 5'-[GA]U(1-3)AGU-3' motif located in the 3' UTR of the target mRNA (By similarity). Binds to the mRNA of three Arp2/3 complex components arx-1, arx-2 and arx-3 and negatively ... | Caenorhabditis elegans |
G5EFS4 | DCPS_CAEEL | MKRIADEELVREERAEESTQKWLQDAKFQEILGADSSHKSLFVLLSHPDGSQGILLANKSPFSEEKSDIEKLLATAQLQEISRNDIFGSYNIEIDPKLNLLKSQLIYPINDRLIAKYRQEEKFVIRETPELYETVTRPYIEKYQLNLNWVYNCLEKRSEVDKIVFEDPDNENGFVLLQDIKWDGKTLENLYVLAICHRHGLKSVRDLTGDDLEMLYNMRDKSLEAINQKYGLKTDQIKCYFHYQPSFYHLHVHFINLKYDAPASTTMSAILLDDVINNLELNPEHYKKSTLTFTRKNGDKLMEMFREALKN | 3.6.1.59 | null | deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; purine ribonucleotide metabolic process [GO:0009150]; response to heat [GO:0009408]; RNA catabolic process [GO:0... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932] | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; adenylylsulfatase activity [GO:0047627]; RNA 7-methylguanosine cap binding [GO:0000340]; sulfate adenylyltransferase (ADP) activity [GO:0004780] | PF05652;PF11969; | 3.30.428.10;3.30.200.40; | HIT family | null | SUBCELLULAR LOCATION: Nucleus. | CATALYTIC ACTIVITY: Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP; Xref=Rhea:RHEA:65388, Rhea:RHEA-COMP:17165, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58285, ChEBI:CHEBI:156461, C... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.2 uM for m7GpppBODIPY {ECO:0000269|PubMed:12871939}; KM=8.52 uM for GpppBODIPY {ECO:0000269|PubMed:12871939}; KM=5.04 uM for ApppBODIPY {ECO:0000269|PubMed:12871939}; Note=kcat is 0.174 sec(-1) with m7GpppBODIPY as substrate. The catalytic efficiency with m7GpppB... | null | null | null | FUNCTION: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m... | Caenorhabditis elegans |
G5EFT4 | AMP1_CAEEL | MAPPHPRDPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDVKQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNE... | 3.4.11.6 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P09960}; Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:P09960}; | leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] | cytosol [GO:0005829]; nucleus [GO:0005634] | aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] | PF09127;PF01433;PF17900; | 3.30.2010.30;1.10.390.10;1.25.40.320;2.60.40.1730; | Peptidase M1 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9774412}. | CATALYTIC ACTIVITY: Reaction=Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.; EC=3.4.11.6; Evidence={ECO:0000305|PubMed:9774412}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.39 mM for L-Lys-pNitroaniline {ECO:0000269|PubMed:9774412}; KM=0.43 mM for L-Arg-pNitroaniline {ECO:0000269|PubMed:9774412}; KM=0.46 mM for L-Met-pNitroaniline {ECO:0000269|PubMed:9774412}; KM=0.9 mM for L-Val-pNitroaniline {ECO:0000269|PubMed:9774412}; KM=1.9 mM... | null | null | null | FUNCTION: Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins. {ECO:0000269|PubMed:9774412}. | Caenorhabditis elegans |
G5EFT5 | HSF1_CAEEL | MQPTGNQIQQNQQQQQQLIMRVPKQEVSVSGAARRYVQQAPPNRPPRQNHQNGAIGGKKSSVTIQEVPNNAYLETLNKSGNNKVDDDKLPVFLIKLWNIVEDPNLQSIVHWDDSGASFHISDPYLFGRNVLPHFFKHNNMNSMVRQLNMYGFRKMTPLSQGGLTRTESDQDHLEFSHPCFVQGRPELLSQIKRKQSARTVEDKQVNEQTQQNLEVVMAEMRAMREKAKNMEDKMNKLTKENRDMWTQMGSMRQQHARQQQYFKKLLHFLVSVMQPGLSKRVAKRGVLEIDFCAANGTAGPNSKRARMNSEEGPYKDVCDL... | null | null | ascaroside biosynthetic process [GO:1904070]; cellular response to heat [GO:0034605]; dauer larval development [GO:0040024]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; determination of adult lifespan [GO:0008340]; innate immune response [GO:004508... | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleus [GO:0005634]; WASH complex [GO:0071203] | calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-... | PF00447; | 1.10.10.10; | HSF family | PTM: Phosphorylated. {ECO:0000269|PubMed:22265419, ECO:0000269|PubMed:29036198, ECO:0000269|PubMed:29042483}.; PTM: Sumoylated (PubMed:29036198). Sumoylation may inhibit transcriptional activity in response to heat shock (PubMed:29036198). {ECO:0000269|PubMed:29036198}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23107491}. Cytoplasm {ECO:0000269|PubMed:22265419}. Note=Localizes constitutively to the nucleus (PubMed:23107491, PubMed:29042483). Localization to the nucleus enhanced by heat shock (PubMed:22265419). Localization to nucleus inhibited by the Insulin/IGF-1-like signali... | null | null | null | null | null | FUNCTION: Functions as a stress-inducible and DNA-binding transcription factor, playing a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMe... | Caenorhabditis elegans |
G5EFU0 | PK2_CAEEL | MNRTFSLRRKVKKSEISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVIRGPSSSFRYNSPLPFGMTNSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPVSQRGYPFNDPSYAPLPLRNQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSPSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTAT... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q17850}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q17850}; Note=Divalent cations such as magnesium or manganese. {ECO:0000250|UniProtKB:Q17850}; | intracellular signal transduction [GO:0035556]; nematode larval development [GO:0002119]; phosphorylation [GO:0016310]; regulation of MAPK cascade [GO:0043408] | cytoplasm [GO:0005737] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00786;PF00069; | 3.90.810.10;1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q17850}; CATALYTI... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. {ECO:0000269|PubMed:17050621, ECO:0000269|PubMed:19797046}. | Caenorhabditis elegans |
G5EFV3 | RSA2_CAEEL | MSKIPVFKGSFKSWLAKNDEKPAKSVLLEPKYRDHHEKISFRNKENMEEGEKPVFVSMANPQPTREDYERYDEDRRLKDKARDLRIARRRNSATPEASPSSDQYFTPEPADDEFVTPSTSKKSQKPRSSDATPVSSKPPRYLPRTPLSEQYTSCLSRKMEENFSRMQELMISGHSPHEARQQTIQESSEQLEPRAKVTRSSSQPPPIDTLKPRVPRIESPLVKKTTETPIRRTSYVDTLVATHQIQLQYSDRVVVGVERQMTKLESIKNLAAANRSPIIAEEAKKRRNEAEAVRKLIEVETQNAKKRAVIQELKDRIDKL... | null | null | embryonic digestive tract development [GO:0048566]; mitotic spindle organization [GO:0007052]; protein localization to organelle [GO:0033365] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; protein phosphatase type 2A complex [GO:0000159] | beta-catenin binding [GO:0008013]; protein-macromolecule adaptor activity [GO:0030674] | null | null | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17218259, ECO:0000269|PubMed:25819561}. | null | null | null | null | null | FUNCTION: Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes (PubMed:17218259). Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions (PubMed:25819561). {ECO:0000269|PubMed:17218259, ECO:0000269|PubMed:25819561}. | Caenorhabditis elegans |
G5EFV5 | CDK7_CAEEL | MSRRYDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKLTDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYMALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQPQKRSRRLDDDG... | 2.7.11.22; 2.7.11.23 | null | cell division [GO:0051301]; mitotic cell cycle, embryonic [GO:0045448]; mRNA transcription [GO:0009299]; phosphorylation [GO:0016310]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985] | ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily | null | null | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000250|UniProtKB:P50613}; CATALYT... | null | null | null | null | FUNCTION: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1. {ECO:0000269|PubMed:11960010}. | Caenorhabditis elegans |
G5EFV8 | VPS52_CAEEL | MPRTRVNLQKSEANDRSFTISSLEFCLSQLRKADPNLVKKAIASGDGLTESKNDVSTRLSEAHRYSVQQCLDNSEQLAQLHNQLVHCDNVFERLQATLYSFQDNLGSIGQDMKNLQLQSHHIHQELENRQKVRVELSQFVDDIAVSQTMMKTINDTDANDRGFLEALHELHHKITLILQRGNGDAVAVNDTMPILEGLKLKAVVKVREWLLQKMFQFRKPLSNYQVFQHQLLKCRFFYEFLLHHDLISAKELQDEYIDTISKMFFTYFKAYATRLFKLAMKDVATKEDALGSIDFAKPAGLGAIFSSKQHVVRNKATVFS... | null | null | endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; negative regulation of dense core granule transport [GO:1904810]; positive regulation of dense core granule transport [GO:1904811]; positive regulation of locomotion involved in locomotory behavior [GO:0090326];... | cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] | small GTPase binding [GO:0031267]; syntaxin binding [GO:0019905] | PF20655;PF04129; | null | VPS52 family | null | SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21613545}. Perikaryon {ECO:0000269|PubMed:27191843}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27191843}. Note=Co-localizes with rab-2 to perinuclear puncta in the perikaryon. Co-localizes with the small GTPases rab-6.1 and rab-6.2 a... | null | null | null | null | null | FUNCTION: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo t... | Caenorhabditis elegans |
G5EFW7 | IF122_CAEEL | MRPNLLWVDKILDENNEAGVCIYDLAFKPDGSELLLAADNKVYLFDVNEGGQMQTLKGHKDLVYTVAWSHNGELFASGGADKLVILWNEKHEGTLRYSHTDVIQCMMFNPCNQILLTCALNEFGLWSTADKNVIKQRSVVRCCSCAWNTDGTIFAIGHGDGTITLRKGTNATEEPSIIIQRDNEPIWGIAFSSNRTFASRDSQGNPMGIDEIMAVIDWNKTLSFYSLDGTFIESKNLEFEPHCISYCLNGEYLLIGGSDKILKIYTRKGVLLGTVAQMDHWIWSVTVRPNSQTVAMGCVDGTIACYNLVFSTVHCVDHAR... | null | null | chemotaxis [GO:0006935]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; non-motile cilium assembly [GO:1905515]; positive regulation of dauer larval development [GO:0061066]; protein localization to cilium [GO:0061512]; receptor localization to non-motile cilium [GO:0097500]; regulation o... | ciliary basal body [GO:0036064]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; non-motile cilium [GO:0097730] | null | PF00400; | 1.25.40.470;2.130.10.10; | null | null | SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305|PubMed:11301258}. Note=Shuttles at the same rate as intraflagellar transport (IFT) complex B proteins such as osm-1, osm-5 and osm-6 along the cilia of the amphid and phasmid sensory neurons. {ECO:0000269|PubMed:11301258}. | null | null | null | null | null | FUNCTION: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:28479320). Plays a role in chemotaxis and sensory perception (PubMed:7240452, PubMed:7705621). Required for entry into and exit from the dauer larval ... | Caenorhabditis elegans |
G5EFX6 | SLIT1_CAEEL | MLICFIFILLIPESATCPAECVCVDRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDFSSLMNLKALQLMDNQIVTIHNQSFSSLVFLQKLRLSRNRIRHLPDNVFQNNLKLTHLDLSENDITVVSDAQLQGPEFLEVLNLDKNHIFCLENNVISSWVSLEVLTLNGNRLTTFEEPSNARFRQLDLFNNPWNCDCRLRWMRKWLEKAEGQNKTVCATPLNLQGSSIEILQDKFMTCSGNRKRRYKKTCETAEICPLPCTCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQISSIPSHSFKNLKNLTRLDLSK... | null | null | axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dorsal/ventral axon guidance [GO:0033563]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron migration [GO:0001764]; regulation of sensory neuron axon guidance [GO:1905489... | extracellular region [GO:0005576] | calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; signaling receptor binding [GO:0005102] | PF00008;PF12661;PF02210;PF00560;PF13855;PF01463;PF01462; | 2.60.120.200;2.10.25.10;3.80.10.10; | null | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. | null | null | null | null | null | FUNCTION: Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. {ECO:0000269|PubMed:11604136}. | Caenorhabditis elegans |
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