ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q84FH6
MVRGIRGAITVEEDTPEAIHQATRELLLKMLEANGIQSYEELAAVIFTVTEDLTSAFPAEAARQIGMHRVPLLSAREVPVPGSLPRVIRVLALWNTDTPQDRVRHVYLREAVRLRPDLESAQ
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. Catalytic Activity: chorismate = prephenate Sequence Mass (Da): 13650 Sequence Length: 122 Pathway: Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1. Subcellular Location: Cytoplasm EC: 5.4.99.5
Q8G5X4
MTARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFREVEADLIADMLEDFDGIFSLGGGAPMTPSTQHALASYIDHGGRVVYLDADPAEAMERANRGGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLTPQGAAKKVIDMVSERAVHVTGAAIEPYDVVIGEGAMNHLVDVLGPKPAKIALIHTQPVQRHSDRARALLRQGGYEVSDIVIPDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCPTSLLAMVDASTGGKTGINTPQGKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKSGFIRDPEILHILEDHAAELRAFDGSTFLGSPLEDVVAELIERTVKVKAYHVSSDLKEKGLREFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASMGLPTSWNGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPAEAVEEAFRRIQQ
Catalytic Activity: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate Sequence Mass (Da): 58712 Sequence Length: 540 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. Subcellular Location: Cytoplasm
P0A4Z3
MAPKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPSPSEAAT
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 18583 Sequence Length: 176 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
Q9CCS5
MAPKAVLVGLPGAGKSTIGRRLSKALGVSLLDTDAAIEKQTGRSIADIFAIDGEEEFRRIEEGVVRAALVEHDGVVSLGGGAVTSPGVCAALAGHIVIYLEINAEEAMRRACGSTVRPLLAGPDRAEKFQDLMARRVPLYRRVATIRVDTNCHNLGAVVRYIMARLQAQLATPVSGGDRKSSEAERSGAPLRKSSEVVK
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 21084 Sequence Length: 199 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
B2HNC7
MAPKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDAAIEQQAGRSIAEIFATDGEEEFRRIEEEVVRAALADHDGVLSLGGGAVTSPGVRSALDGHTVVYLEISAAEGVRRTGGSNVRPLLAGPDRAEKFRALMSQRIPLYRRVSTIRVDTNRRNPGAVVRYIMSRLDDPTPNTSPSSTASGAAT
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 19347 Sequence Length: 184 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
Q5FAD3
MKNFNGKLILIGLMGAGKTTLGRQMAQRLDYRFYDSDHEIAAAAGVPIPTIFEMEGEQGFRSRETAILKKLIVLPHIVLSTGGGAVLKEENRALIRKSGTVVYLHAPPETLLERTRCDNSRPLLQVADPLAKLRELYAARDPVYRQTADFTVESANCRETVQTLLKRLSR
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 18980 Sequence Length: 170 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
Q82TC0
MHFRYNYRMQRSKTPNTKNSDTGSIPGNIILIGMMGSGKTTVGKLLANLVGKTFIDIDHEIQRRTGVGIPVIFEIEGEAGFRKRESEVLRDIVRQQNIVLATGGGAILHPDNRALLRQHGTVVYLCAPVTELRRRTYLDKNRPLLQTGNVHAKLIELFTQRDPLYRETAHIIMDSGRQSARAFVQKLIQKLRQSNQEFTAAGSPPCVKPSE
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 23703 Sequence Length: 211 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
Q2YBB2
MISTDAVAPAVDVKGEAGDRAATGNIFLVGMMGAGKTTVGRLLSHFLEKTFYDSDREIQKRTGVSIPTIFEIEGEEGFRRRETEILSELMNARNIILATGGGAVLSGVNRAMLKHGGTVIYLRASIDDLWRRTRHDKNRPLLQTSDPRARLAELFVQRDPLYRETAHIVVESGKRSPRHLAQSLAQQLTISSRTG
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 21542 Sequence Length: 195 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
B2IX35
MSSLLQGVNLYLIGMMGVGKTTVGPLLAKHLGYGFLDLDGVIAKATDKSINQLFAEEGEAGFRQIESDVLSQVCAFTKLTIATGGGIVLRRENWGYLHHGLIVWLDVPVELIYRRLAEDTTRPLLQDADLKGKLRSLLEQRTPLYSQADLHITVQEGETPEDIANRIIEVIPNVLKPQASH
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 19959 Sequence Length: 181 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
A4W763
MTQPIFLVGPRGCGKTTVGLELARACQSQFVDTDHWLQTKAGRTIAEIVEKEGWETFRALETETLKAVSAPSTVIATGGGIILAEHNRGFMREHGIVIYLCAPVATLVERLEAFPEEGQRPTLTGKPISDEVSEVLAERDALYREAAHHVVDASQTPEQVVSHIVTALRLACAS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 18890 Sequence Length: 174 Domain: The LID domain closes over the active site upon ATP binding. Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
B7LMJ7
MIQPLFLVGPRGCGKTTVGKALADALERRFVDTDQWLQANVQMTVADIVEREGWAGFRAREAAALEAVTAPATVVATGGGIILAEQNRHFMRNNGIVIYLSAPVDVLVNRLEAEPEVGLRPTLTGKSLSEEVAEVLEQRDILYRETANIIVDATYEPGQVISEIRALLDQMALRNLGGAYT
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Catalytic Activity: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) Sequence Mass (Da): 19690 Sequence Length: 181 Domain: The LID domain closes over the active site upon ATP binding. Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. Subcellular Location: Cytoplasm EC: 2.7.1.71
Q741J6
MIVQVINGPNLGRLGRREPDVYGDTTHDQLAALIEAEAAALGLKAIVRQSDSEAELLDWIHGAADANQPVILNAGGLTHTSVALRDACAELSAPLIEVHISNVHAREEFRRHSYLSPVATGAIVGLGVQGYLLALRYLAGRPA
Function: Catalyzes a trans-dehydration via an enolate intermediate. Catalytic Activity: 3-dehydroquinate = 3-dehydroshikimate + H2O Sequence Mass (Da): 15192 Sequence Length: 143 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. EC: 4.2.1.10
Q1QLB8
MARTIYVLNGPNLNMLGTREPETYGRATLADVEKLCADTAGDFGLAADCRQSNREGELIDFIHDAHAKKAAGIVINAGGYSHTSVALHDALVAVNIPTVEVHISNIHAREDFRHHSFTARAAFASLCGFGIDGYRLAINGLAAKIGAVKSGAKVKS
Function: Catalyzes a trans-dehydration via an enolate intermediate. Catalytic Activity: 3-dehydroquinate = 3-dehydroshikimate + H2O Sequence Mass (Da): 16530 Sequence Length: 156 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. EC: 4.2.1.10
A6Q235
MKVMVIQGPNLNMLGIREQHIYGPMKLEDIHKQMKNFADANGLDIEFFQSNLEGEIVDKIQESLGDADGIIINAGAYTHTSIAIRDAIAAVQLPTIEVHLSNVYRREEFRQKSMIAPVCAGVITGFGPFSYHLAMVAMHQIFQEIEALKAQQPQQA
Function: Catalyzes a trans-dehydration via an enolate intermediate. Catalytic Activity: 3-dehydroquinate = 3-dehydroshikimate + H2O Sequence Mass (Da): 17380 Sequence Length: 156 Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. EC: 4.2.1.10
Q8N5I2
MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYEAPPSYEQSCGGVEPSLTPES
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates . Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles . More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles . By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway . PTM: Ubiquitinated . Ubiquitination by WWP2; promotes localization to extracellular microvesicles . Ubiquitinated by WWP1 . Sequence Mass (Da): 45981 Sequence Length: 433 Domain: The PPxY motifs mediate interaction with WW domain-containing ubiquitin-protein ligases. Subcellular Location: Cell membrane
Q99KN1
MGRVQLFEIRLSQGRVVYGPGEPLAGTVHLRLGAPLPFRAIRVTCMGSCGVSTKANDGAWVVEESYFNSSLSLADKGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAKRWIYDVRTIAEVEGTGVKAWRRAQWQEQILVPALPQSALPGCSLIHIDYYLQVSMKAPEATVTLPLFVGNIAVNQTPLSPCPGRESSPGTLSLVVPSAPPQEEAEAVASGPHFSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHSLHPPLCISIGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYEAPPSYEQSCGAAGTDLGLIPGS
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates . Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles . More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway . PTM: Ubiquitinated. Ubiquitination by WWP2; promotes localization to extracellular microvesicles. Ubiquitinated by WWP1. Sequence Mass (Da): 46330 Sequence Length: 434 Domain: The PPxY motifs mediate interaction with WW domain-containing ubiquitin-protein ligases. Subcellular Location: Cell membrane
Q96B67
MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
Function: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors . Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation . May recruit NEDD4 to ADRB2 . Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes . Location Topology: Peripheral membrane protein Sequence Mass (Da): 46395 Sequence Length: 414 Subcellular Location: Cytoplasm
Q8NCT1
MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake . Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 . Location Topology: Peripheral membrane protein Sequence Mass (Da): 45479 Sequence Length: 418 Subcellular Location: Early endosome
A0A0B4J1F4
MGGEAGADGPRGRVKSLGLVFEDESKGCYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAWGPSAGARVCIGGGSPAASSEVEYLNLRLSLLEAPAGEGVTLLQPGKHEFPFRFQLPSEPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKRLMLELPLVIGTIPYSGFGRRNSSVASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHVPPYPQPSDCDGEACYSMFACIQEFRFQPPPLYSEVDPHPGDAQETQPVSFIL
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates . Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles . May play a role in glucose uptake (By similarity). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 44970 Sequence Length: 415 Subcellular Location: Early endosome
Q7TP90
MSSQSSILVDFRPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVYIHIPGAKKLMLELPLVIGTIPYSGFGRRNSSMASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHIPPYPQPSACDGEACYSMFACIQEFRFQPPPLYSESHAQLFCLQPVGPTNRAHF
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65. Location Topology: Peripheral membrane protein Sequence Mass (Da): 33275 Sequence Length: 300 Subcellular Location: Early endosome
O24972
MRFSIFFKVVALFMITLFSFGAFAYYFVSSQISHENYQNEMRHYQFVTTINEILNNYSDYRAIEDYLYKIGFRETTIENLEKVLAKRRHQLHHRNIGYAEVFKFSDMVFILLKKDEHFVLYKDLHSVSYRNYFLAITVGLLLILFLFLFVLQSLLPLRELRSQVKPFAQGDKSVSCKSKQKDEIGDLANEFDNCILKINAMNESRVLFLRSIMHELRTPITKGKILSSMLKEELSCKRFSSIFDHLNMLIEQFARIEQLASKNYGSNKEKFLMSDLIDKIEKMLLIDEDKESPIHVSSSNYIIEADFELFSIALKNMVDNAIKYSDDKQVFLDFIGNNLVVSNKSKPLKEDFEKYLQPYFKSSNPSQAHGFGLGMYIIKNALEAMGLNLSYHYSNGRICFTIHDCVFNSFYDLEEDNEELPPPPPKI
Function: Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways . Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR . In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH . Participates also in acidic acclimatation in a phosphorylation-independent pathway by regulating acid-induced trafficking of urease and its accessory proteins to the inner membrane . PTM: Autophosphorylated. Location Topology: Multi-pass membrane protein Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 49917 Sequence Length: 427 Subcellular Location: Membrane EC: 2.7.13.3
O27106
MMNDKKITSFIALPDLLSMLNASSGYLSILLSIDGSLNAACILMLLAVLFDSLDGWVARKTGRIDIHGFGKNMDSLSDVISFGVAPAILIYSAAVDFRYINILVGPLIVLCGILRLSRFNVLTGGGKNFTGLPIPVAAVTISSFYLTGFYSELSAAFIMIAVSVLMISSIEYPRVDGMGASTALILIIATIISVAAVEILQAASVVAGPVAIILFIATLTYIAVPILPKRDVI
Function: Involved in the lipid biosynthesis. Catalyzes the formation of unsaturated archaetidylserine from CDP-unsaturated archaeol and L-serine. Activity with ester-linked substrate analogs containing straight aliphatic chains (typical bacterial substrates) is two to three times higher than that with the corresponding ether-type substrate (typical archaeal substrates). Both enantiomers of CDP-unsaturated archaeols with ether-linked geranylgeranyl chains and CDP-saturated archaeol with ether-linked phytanyl chains are similarly active. The enzyme also accepts D-serine, although activity is only about third of that with L-serine. Catalytic Activity: CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 24618 Sequence Length: 233 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Membrane EC: 2.7.8.38
P14000
MKSAPFLFLLGLLGLVTAQTQDPALLDLLRENPDLLSLLLQSNEHRAPLVKPNVVLLVADHMGSGDLTSYGHPTQEAGFIDKMAAEGLRFTNGYVGDAVCTPSRSAIMTGRLPVRIGTFGETRVFLPWTKTGLPKSELTIAEAMKEAGYATGMVGKWHLGINENSSTDGAHLPFNHGFDFVGHNLPFTNSWSCDDTGLHKDFPDSQRCYLYVNATLVSQPYQHKGLTQLFTDDALGFIEDNHADPFFLYVAFAHMHTSLFSSDDFSCTSRRGRYGDNLLEMHDAVQKIVDKLEENNISENTIIFFISDHGPHREYCEEGGDASIFRGGKSHSWEGGHRIPYIVYWPGTISPGISNEIVTSMDIIATAADLGGTTLPTDRIYDGKSIKDVLLEGSASPHSSFFYYCKDNLMAVRVGKYKAHFRTQRVRSQDEYGLECAGGFPLEDYFDCNDCEGDCVTEHDPPLLFDLHRDPGEAYPLEACGHEDVFLTVKSTVEEHKAALVKGTPLLDSFDHSIVPCCNPANGCICNYVHEPGMPECYQDQVATAARHYRP
Cofactor: Binds 1 Ca(2+) ion per subunit. Function: May be a structural component of the extracellular matrices involved in cell movement during morphogenesis. PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Catalytic Activity: an aryl sulfate + H2O = a phenol + H(+) + sulfate Sequence Mass (Da): 60952 Sequence Length: 551 Subcellular Location: Cytoplasm EC: 3.1.6.1
P51691
MSKRPNFLVIVADDLGFSDIGAFGGEIATPNLDALAIAGLRLTDFHTASTCSPTRSMLLTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGLKPEQTPHARGFERSFSLLPGAANHYGFEPPYDESTPRILKGTPALYVEDERYLDTLPEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGRYDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLGFLDRHYDNSLENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFATVMDVTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAAHDENTVTGWELFGMRAIRQGDWKAVYLPAPVGPATWQLYDLARDPGEIHDLADSQPGKLAELIEHWKRYVSETGVVEGASPFLVR
Cofactor: Binds 1 Ca(2+) ion per subunit. Function: Hydrolyzes the bond between sulfate and the aromatic ring in a compound such as 4-nitrocatechol sulfate. PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Catalytic Activity: an aryl sulfate + H2O = a phenol + H(+) + sulfate Sequence Mass (Da): 59946 Sequence Length: 536 Subcellular Location: Cytoplasm EC: 3.1.6.1
P28607
MQKISIIFNLFLSLGCLAFTFNGSASETKNEWITLGTMAGPIPNAKHSQPANAMLVNGNTYVVDAGDGTAGQLAKVGLDIKNVDAVFLSHLHFDHTGGLPAILSLRWQTSARNELVVYGPPGTQQTVDGIFEYMTYGTLGHYGVPGQVPAPANTNIKVVEVEDGTQLKLPDFTVDVIRNSHYSWPKGSEEWKKFQALSFKFSLQDYTVVYTGDTGPSSAVEKLSSGVDLLVSEMMDIDHTVNMIKETNPQMPKGKFIGIHKHLSKHHLSPKQVGELAKAANVGSLVITHMAPGLDTQAEIDFYTKQVASEYKGPISVAQDLNRYELKR
Function: May function as a glycosulphohydrolase involved with desulfation of sulfated polysaccharides. Catalytic Activity: an aryl sulfate + H2O = a phenol + H(+) + sulfate Sequence Mass (Da): 35793 Sequence Length: 328 Subcellular Location: Periplasm EC: 3.1.6.1
Q10723
MLQRLVVALCLLGFAALTAAAAHQRPNFVVIFTDDQDGIQNSTHPRYQPKLHEHIRYPGIELKNYFVTTPVCCPSRTNLWRGQFSHNTNFTDVLGPHGGYAKWKSLGIDKSYLPVWLQNLGYNTYYVGKFLVDYSVSNYQNVPAGWTDIDALVTPYTFDYNNPGFSRNGATPNIYPGFYSTDVIADKAVAQIKTAVAAGKPFYAQISPIAPHTSTQIYFDPVANATKTFFYPPIPAPRHWELFSDATLPEGTSHKNLYEADVSDKPAWIRALPLAQQNNRTYLEEVYRLRLRSLASVDELIDRVVATLQEAGVLDNTYLIYSADNGYHVGTHRFGAGKVTAYDEDLRVPFLIRGPGIRASHSDKPANSKVGLHVDFAPTILTLAGAGDQVGDKALDGTPLGLYANDDGNLLADYPRPANHRNQFQGEFWGGWSDEVLHHIPRYTNNSWKAVRVYDEDNQQAWKLIVSCTNERELYDLKTDPGELCNIYNKTRAAVRTRLEALLAVLVVCKGESCTNPWKILHPEGSVNSWNQSLDRKYDKYYANVAPFQYRTCLPYQDHNNEVSAFRSTVAAAAAAAAAAAAQQPGRRRMYTWTSAGRQLSATASAIATSPQPRSEPFVAEVERHSVPVPAEVLQSDVAKWFDNPLALA
Cofactor: Binds 1 Ca(2+) ion per subunit. Function: Is commonly produced by soil microorganisms and plays an important role in the mineralization of sulfates. PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Catalytic Activity: an aryl sulfate + H2O = a phenol + H(+) + sulfate Sequence Mass (Da): 72287 Sequence Length: 649 Subcellular Location: Periplasm EC: 3.1.6.1
P18634
MAPKISISLNPPYNGEFYSSNDQMSGIVSLQLTKALSIRKISVILKGFSETLTKIDQEYMFQQNGMMMPGQDNKSFHTLMKFEQRVFPPDNVWNALDGSSKPFKVKPGSYNYSFQFDKFPRKPECLKNHTAKTVAFVTRSNARLPPTFNSHWQEFNKIDNLDLYFYSFGKVIYMVQVQLELGKSSSWFKPFHKLIREIETFEFIPEPKDLIIEPDEDDNEELNAFSNNSRGNSMVTNNEFFNSSNLKVPSKDVKVVNGVGYIKSDRNFSQANSILIENGDIRSRPVSSVTSTRQSTRLVNGMKVFPSTYKMGLPDGESNMRIEVRSRDLKQIYRKDYLFRSGSQNFDKVYVVMEGNIASLSKMQITPLKLQLNLLETTTYLSQGIANGNYSSLKLIEIDLNQLKSNKPLLDLNEIRENFDGSMFECELRLKDHPILRKLVFNEEDYRHRGNRLYSFKTCTIKRTFSLQLLIEWGINGIRKQSEVNIDPVQIFCQVREHVEAEALPRYVPPPTYTEMAS
Function: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli. PTM: Ubiquitinated by RSP5. Sequence Mass (Da): 59758 Sequence Length: 518 Subcellular Location: Cytoplasm
Q9UT55
MKFLNPPFPYSMTSDPESFGHECFTRRWGIILTGIEKDVSERLSKLASTSKDSEVVAQGKPLLNDLEAFKSDIKNDRPLVPLEGEGQDIVEYNEELKQLDNASWGNAPWLYSECYYYRRISLIFARYSEWKAYDPFFQQKDSTLKSSRAAVEELAGRYCLLEEELNSIAKKGDSHIAYMVFVEMAQISLWGNATDLSLLTNLSYEELQNLQGQKVVEESQKNILVNDFPTVWSKLKDVHNGRIDFVLDNAGFELYVDLIFAAYLLKAGIAKEIVLHPKDFPWFVSDVLPYDIEYLLTNLDTIFPTESVTKFATDLRSFSAKGQLRLRTDPFWTTAHYFGRMPDFAAGLLTELEKSDMIFFKGDLNYRKLTGDCLWPRTTPFGKTLGPIANAINACALRTCKADVVVGLPDGLYEKIAKDLPHWERTGKYAVVEFCPKA
Function: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Catalytic Activity: beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate Sequence Mass (Da): 49895 Sequence Length: 438 Domain: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. Subcellular Location: Cytoplasm EC: 3.1.3.-
Q94GF1
MASLVLSLRIAPSTPPLGLGGGRFRGRRGAVACRAATFQQLDAVAVREEESKFKAGAAEGCNILPLKRCIFSDHLTPVLAYRCLVREDDREAPSFLFESVEQGSEGTNVGRYSVVGAQPAMEIVAKANHVTVMDHKMKSRREQFAPDPMKIPRSIMEQWNPQIVEGLPDAFCGGWVGFFSYDTVRYVETKKLPFSNAPEDDRNLPDIHLGLYNDIVVFDHVEKKTHVIHWVRVDCHESVDEAYEDGKNQLEALLSRLHSVNVPTLTAGSVKLNVGQFGSALQKSSMSREDYKKAVVQAKEHILAGDIFQVVLSQRFERRTFADPFEVYRALRIVNPSPYMAYLQARGCILVASSPEILTRVEKRTIVNRPLAGTIRRGKSKAEDKVLEQLLLSDGKQCAEHIMLVDLGRNDVGKVSKPGSVKVEKLMNVERYSHVMHISSTVTGELRDDLTCWDALRAALPVGTVSGAPKVRAMELIDQMEGKMRGPYSGGFGGVSFRGDMDIALALRTIVFPTGSRFDTMYSYTDKNARQEWVAHLQAGAGIVADSKPDDEHQECLNKAAGLARAIDLAESTFVDE
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Catalytic Activity: chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate Sequence Mass (Da): 63866 Sequence Length: 577 Pathway: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5. Subcellular Location: Plastid EC: 4.1.3.27
Q9H765
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Sequence Mass (Da): 31642 Sequence Length: 288 Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Cytoplasm
Q91ZT9
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAERDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPVSLKDYLLLLE
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Sequence Mass (Da): 31735 Sequence Length: 288 Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Cytoplasm
Q96DX5
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. Sequence Mass (Da): 31858 Sequence Length: 294 Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Mitochondrion
Q91ZT8
MDGEQRGRSDRPGGSPHLPFLSNPLMGDVVSDWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPHPETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVNQGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDLVPLESPLIQIFLQNEGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL
Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity). Sequence Mass (Da): 31656 Sequence Length: 290 Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Mitochondrion
A0A0F7RJ52
MKHAKQIAEHATIQSFLNCYLRETGSGEWITEDKRIEDIFYHLFQRDTCSTYLCCRLSAQNITLYGEVIYKSPTDRHLFGEQFYYQMGDSNSVMKADYVTVITFLIKEMSINYGEGTNPAELMLRVIRSCQNIEEFTKERKEDTSALYGFHTSFIEAEQSLLFGHLTHPTPKSRQGILEWKSAMYSPELKGECQLHYFRAHKSIVNEKSLLLDSTTVILKEELRNDEMVSKEFISKYCNEDEYSLLPIHPLQAEWLLHQPYVQDWIEQGVLEYIGPTGKCYMATSSLRTLYHPDAKYMLKFSFPVKVTNSMRINKLKELESGLEGKAMLNTAIGEVLEKFPGFDFICDPAFITLNYGTQESGFEVIIRENPFYSEHADDATLIAGLVQDAIPGERTRLSNIIHRLADLESRSCEEVSLEWFRRYMNISLKPMVWMYLQYGVALEAHQQNSVVQLKDGYPVKYYFRDNQGFYFCNSMKEMLNNELAGIGERTGNLYDDYIVDERFRYYLIFNHMFGLINGFGTAGLIREEILLTELRTVLESFLPYNREPSTFLRELLEEDKLACKANLLTRFFDVDELSNPLEQAIYVQVQNPLVREVAVRS
Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Catalyzes the ATP-dependent condensation of citric acid and spermidine to form N(8)-citryl-spermidine . It can also catalyze the condensation of several di- and triamine analogs of spermidine with citric acid and the condensation of the citric acid analog tricarballylic acid with spermidine . Required for growth in iron-depleted medium and for full virulence in a mouse model of infection . Catalytic Activity: ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine Sequence Mass (Da): 69937 Sequence Length: 602 Pathway: Siderophore biosynthesis; petrobactin biosynthesis. EC: 6.3.2.-
Q81RQ8
MRMDMYHTKILKAIESEDYISVRRRVLRQLVESLIYEGIITPARIEKEEQILFLIQGLDEDNKSVTYECYGRERITFGRISIDSLIVRVQDGKQEIQSVAQFLEEVFRVVNVEQTKLDSFIHELEQTIFKDTIAQYERCNKLKYTQKSYDELENHLIDGHPYHPSYKARIGFQYRDNFRYGYEFMRPIKLIWIAAHKKNATVGYENEVIYDKILKSEVGERKLEAYKERIHSMGCDPKQYLFIPVHPWQWENFIISNYAEDIQDKGIIYLGESADDYCAQQSMRTLRNVTNPKRPYVKVSLNILNTSTLRTLKPYSVASAPAISNWLSNVVSQDSYLRDESRVILLKEFSSVMYDTNKKATYGSLGCIWRESVHHYLGEQEDAVPFNGLYAKEKDGTPIIDAWLNKYGIENWLRLLIQKAIIPVIHLVVEHGIALESHGQNMILVHKEGLPVRIALKDFHEGLEFYRPFLKEMNKCPDFTKMHKTYANGKMNDFFEMDRIECLQEMVLDALFLFNVGELAFVLADKYEWKEESFWMIVVEEIENHFRKYPHLKDRFESIQLYTPTFYAEQLTKRRLYIDVESLVHEVPNPLYRARQLNIQKSVATGGNYANC
Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Catalyzes the ATP-dependent condensation of spermidine with N(8)-citryl-spermidine or N(1)-(3,4-dihydroxbenzoyl)-N(8)-citryl-spermidine, two intermediates in petrobactin biosynthesis pathway . Catalytic Activity: ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) Sequence Mass (Da): 72014 Sequence Length: 612 Pathway: Siderophore biosynthesis; petrobactin biosynthesis. EC: 6.3.2.-
Q81RQ7
MLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDTEIKVYNEALNCDIDEVPIVMAPVSHSYGLICGTLSAITRGSKPIIITNKNPKFALNIVRNTEKHIVYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLPEALFYKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIGSDENAPEEIIVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTT
Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Catalyzes the adenylation of 3,4-dihydroxybenzoate (3,4-DHBA) to the corresponding AMP ester, followed by the transfer of the activated unit to the phosphopantetheine thiol of the aryl-carrier protein AsbD . Catalytic Activity: 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate Sequence Mass (Da): 46510 Sequence Length: 412 Pathway: Siderophore biosynthesis; petrobactin biosynthesis. EC: 6.2.1.62
A0A0J1I1I3
MRREALKNAVLKIMTEKMELKNVTHLEETMRLNQDLYIDSVMMLQLIVYIEMDVKLCVPEDEVDPKAFLTVGSLLDFMEELQPLQDVNVNN
Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Aryl-carrier protein that activates 3,4-dihydroxybenzoate (3,4-DHBA) prior to its incorporation into petrobactin . PTM: Activated by the transfer of a 4'-phosphopantetheine group from CoA to Ser-40. Sequence Mass (Da): 10628 Sequence Length: 91 Pathway: Siderophore biosynthesis; petrobactin biosynthesis.
Q81RQ5
MTSIKVHCLVSCFCEIIKRRSDIDFRPFYFGLWDGDFDITEGGIISYHSENINHDHYLLWYEKLYGMKVNEWYDHAKDKDSNVETFLQLVENKPENRYVIVMVDMSLLPERENKFHQKPFPHYLMISETEKEEEWFMLDPDFRWEGNMEREKVLYSVQDNPFGGGYFIDVEEIQEPTAEMVASYFIETFKRNDNELTMELKNLIIKMANEEEGYLLSGLVAAVKQIPVLAIRKYSYEHAFAYFRETLQYSEQEFDYWCDRVEDIVQGFTNVQYRAIKMAMTNNKGMLLSIVEKLDEMNAIELQIKTELERQFLSWKEMKSNESVLVF
Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Transfers the activated 3,4-dihydroxybenzoate (3,4-DHBA) moiety from 3,4-DHBA-loaded AsbD to different receipient molecules, including N-citryl-spermidine, N8,N'8-citryl-bis(spermidine) and N1-(3,4-dihydroxybenzoyl)-N8,N'8-citryl-bis(spermidine) . Also catalyzes the transfer of the activated 3,4-DHBA moiety from 3,4-DHBA-loaded AsbD to spermidine to generate DHB-spermidine (DHB-SP) . Catalytic Activity: 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine Sequence Mass (Da): 39032 Sequence Length: 327 Pathway: Siderophore biosynthesis; petrobactin biosynthesis. EC: 2.3.2.-
Q81RQ4
MKYSLCTISFRHQLISFTDIVQFAYENGFEGIELWGTHAQNLYMQEYETTERELNCLKDKTLEITMISDYLDISLSADFEKTIEKCEQLAILANWFKTNKIRTFAGQKGSADFSQQERQEYVNRIRMICELFAQHNMYVLLETHPNTLTDTLPSTLELLGEVDHPNLKINLDFLHIWESGADPVDSFQQLRPWIQHYHFKNISSADYLHVFEPNNVYAAAGNRTGMVPLFEGIVNYDEIIQEVRDTDHFASLEWFGHNAKDILKAEMKVLTNRNLEVVTS
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence . Catalyzes the conversion of 3-dehydroshikimate to 3,4-dihydroxybenzoate (3,4-DHBA) . Catalytic Activity: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O Sequence Mass (Da): 32589 Sequence Length: 280 Pathway: Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2. EC: 4.2.1.118
Q9M6A3
MKNLDHIAASVDWEKESLPEYQDLIFLLFFALFFPVLRFILDRFVFEALAKRMIFGKKTVVNINGREERKKINKFKESAWKFVYFLSTELLALSVTCNEPWFTDSRYFWAGPGDVVWPNLKMKLKLKLLYMYAGGFYFYSIFATLYWETRRYDFAAQIIHHVTTVSLIVLSYVYGFARIGSVVLALHDGSDVFMEIAKMSKYSGFDLIADIFFSLFALVFTSLRIICYPFWIIRSTCYELLYVLDIQKERTTGIILYFVFNALLICLLVLHLFWFKIILRMVKNQILSRGHITDDVREDSESDDDHKD
Function: Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36332 Sequence Length: 308 Subcellular Location: Endoplasmic reticulum membrane
A0A3G5BIB1
MRFLNIFLFFAVMIAFVSASPVLEEEEIDIEPRITCDLIGNERLCVVHCLAKGFRGGWCDSRKVCNCRR
Function: The recombinant peptide moderately increases Kv11.1/KCNH2/ERG1 currents and shifts the voltage-dependence of the channel activation to hyperpolarised potentials . In vivo, induces neurotoxic effects when injected into insects (tested on L.cuprina and A.domesticus) . Sequence Mass (Da): 7939 Sequence Length: 69 Domain: Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). Subcellular Location: Secreted
Q94BQ3
MDNLSFHDGNIFNLLHTRSQDPSHEVDQRMQFHSSLVRRLSQEQELEGHQGCVNALAWNSNGSLLISGSDDLRINIWNYSSRKLLHSIDTGHTANIFCTKFVPETSDELVVSGAGDAEVRLFNTSRLSGRAEDDNAIIPSALYQCHTRRVKKLAVEPGNPNVVWSASEDGTLRQHDFRESTSCPPAGTAHQECRSVLLDLRSGAKRALADPPKQTLSLKSCDISATRPHLLLVGGSDAFARLYDRRMLPPLASSRKRMPPPPCVNYFCPMHLSERGRTNLHLTHVTFSPNGEEVLLSYSGEHVYLMNVNNGICSTGIMQYTPGDVDNLFSFSNNLHDVESPPQVSTTPQNGFHRSSNAATVKKCTELVEIAKWSLEEGTDVFYAIEAANEVLDAHSNDIESALRHECLCTRAALLLKRKWKNDAHMAVRDCHNARRIDASSFKAHYYMSEALQQLGKCKEALDFATAAQHMNPSDADIVAKVESIKRDLQAAGAEKNEETGAGTTRVLSLSDILYRSEANSDSSHDMSRSEREDSDYDEELELDIQTSLSDDEGRDTDSNSMRGSLNLRIHRVGDDKPMENTVDNASSGTASSSQNDRTSYQPEGAIDMKRRYVGHCNVGTDIKQASFLGQRGEYIASGSDDGRWFIWEKQTGRLMKVLVGDESVLNCIQCHPFDSVVATSGIDNTIKIWSPTASVPSIVAGGSAGPATANVVEVMESNQQKLSRNRENPLSVELMQRFRMQEFAEGNFHPFECTQS
Function: May function as a substrate adapter for CUL4-DDB1 E3 ubiquitin-protein ligase complex (Probable). Negative regulator of fatty acid biosynthetic process and accumulation . Acts as an abscisic acid (ABA) negative regulator . Involved in responses to salt (NaCl) and osmotic (e.g. in response to mannitol and PEG) stresses . PTM: Farnesylated at Cys-754 by FTB/ERA1; this modification triggers an exclusion from the nucleus. Sequence Mass (Da): 83830 Sequence Length: 757 Pathway: Protein modification; protein ubiquitination. Subcellular Location: Nucleus
P46993
MTTLASSIEHKTKHLAAPFENDENPWMKKYCCQCKSCKMSVPVQPWLPRFFVFGILCPVFWLVNLLAWWFLQYWQPHELEFHDLQEDEYPGFYEYEAITKRTVIPIKEEVLQEIRVMQNFSDSNSEEYYESKDGMPSSFLNVNTEQVEDENDTLKKYRYAFLKKVAHDVLESHDLLRKTFRDWNLRSLLGLLIDSILIIFVVLLCKKSR
Function: Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular membranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 24946 Sequence Length: 209 Subcellular Location: Endomembrane system
Q5BKW9
MLPVVVVHGGAGHIPKERTEESTIGVKEAARTGYAILQRGGSAVDAVVEAVALMETNPRFNAGRGSVLNIKGEVEMDALVMDGRTLDSGAVSAVRRIANPVQLARLVMEKTKHLCLTAEGASKFARSMGVPEVPEESLITDYAKMRWKKNLEPDANPVECQMGKMGTVGAVAVDMDGNIACATSTGGMINKMEGRVGDTPCVGCGGYADNKIGAVSPTGHGEAIMKVTLSRLVLFHMEQGKTPEEASDLALAYMKERVDGLGGVVVVDHNGTWAARFSSLQMSWAAAQQGKLHFGLFHGDHFTEPVEEHT
Function: Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. PTM: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. Catalytic Activity: H2O + L-asparagine = L-aspartate + NH4(+) Sequence Mass (Da): 32929 Sequence Length: 310 Subcellular Location: Cytoplasm EC: 3.4.19.5
Q9VXT7
MPRPVLLIHGGAGDISDSRIAGKFAGIKQALRSAWGLLSPDNGSGGGSALDAVEAAVRSMELDENFNAGYGSCLNTSGQVELEASLMEGRDLRAGCITLLRDVMHPITVARRLMEKQRHTFLGGAAAQELALATGSERLQPGALVTEGARLTLKEFEDQVAQGKDPFFARTELTDDKPVPKTDPSGETVGAVAMDASGQIVVGTSTGGITGKWPGRIGDTPILGSGTYADNCRGGVSTTGHGETLMRYNLAQRILSAMEYQGLSAQAAADKECREMTKRLGGTGGAIVVGHSGDLGISFTSRRMAWGYVQDGTIFYGIEGQVVHQEPFTLST
Function: Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. PTM: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. Catalytic Activity: H2O + L-asparagine = L-aspartate + NH4(+) Sequence Mass (Da): 34861 Sequence Length: 332 EC: 3.4.19.5
Q7L266
MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP
Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. PTM: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. Catalytic Activity: H2O + L-asparagine = L-aspartate + NH4(+) Sequence Mass (Da): 32055 Sequence Length: 308 Subcellular Location: Cytoplasm EC: 3.4.19.5
P08243
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
Catalytic Activity: ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate Sequence Mass (Da): 64370 Sequence Length: 561 Pathway: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. EC: 6.3.5.4
Q5UQE1
MCGIICFIQYGGQKIDLVSCLNCLDKLNNRGPDAQSYQVIELGDITIFLGFTRLAIMDTSEAGLQPFKDNNSNYSICNGEIYNYKNLAEKFNIEMQSQCDCEILLPLFNLRGFEGLLSDLDAEFATVIVDKYNSKLYAARDKYGVRPLYYGYNCEKGLIGFASELKALHSVMEYVEQVKPNQYVTIDLSFRPSIPFDLQNFVKLFQFTNYHEYYQSHKSLIDYHEPNIEQLQTSINHLLTEAVRKRLYADRQIGFLLSGGLDSSLIVAIATRLLGPTNIVCFSVGFEGSPDVAAAREVVKFLGIKNHHIVPFSVDIGLNAINDVIKTIETYDITTIRASTPQFIMAKYIQENTDIRVLLSGEGSDEIHGSYKYMRSAPNSQEFHKETIRLLEELYLFDNKRTDRTMAGNGLEVRVPFLDFNYVDFIMNIDPNLLMYKSDYIEKKIIRDAFKGYLPENILYRPKEAFSDAVSSKEINWYRSIQKITEEIYTDEKLQNSNYKFNKPEIKEALYYRDIFNSHYGGRDHIIPHYWLPRFQQNNVLDPSATILPI
Catalytic Activity: ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate Sequence Mass (Da): 63335 Sequence Length: 550 Pathway: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. EC: 6.3.5.4
P78753
MCGILAVHHVAEDIEAFKPKALHLSKQLRHRGPDWSGKAIRNQTILCHERLAIVGVESGAQPLVSDDGKLVLTVNGEIYNHLKLRENLKGNYKFKTYSDCEVILYLYREHGPACANMLDGMFSWVLYDQDKDKVVAARDPIGITTLYQGFSSDSPDTAYFASELKALHPVCDKIIAFPPGHYYDSETKQTVRYFKPSWWDENKIPSNPVDYKLLRETLEASVRKRLMAEVPYGVLLSGGLDSSLIASIAARETEKLANSTSQSEEARTITAWPKLHSFAIGLPGSPDLLAARKVADFLHTFHHEHTFTIDEGLDALRDVIYHLETYDVTTIRASTPMYLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFGNAPSREAFHSECVRRVKNLHLSDCLRANKSTMAWGLEARVPFLDKDFLEVALNIDPEEKMYINGRKEKYILRKAFDTTHDSSLQPYLPQDILWRQKEQFSDGVGYSWIDALKDTAELCISDDEFALPRREWGDDIPTTKEAFWYRKLFDEIFPRQCADTVMRWVPKAEWGCPEDPSGRYQAGHVAALK
Catalytic Activity: ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate Sequence Mass (Da): 63241 Sequence Length: 557 Pathway: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. Subcellular Location: Cytoplasm EC: 6.3.5.4
Q00624
MRGVKLLAACLYLAAAATVVVHAEDPYFHHVWNVTYGTASPLGVPQQVILINGQFPGPNINSTSNNNVIINVFNNLDEPFLLTWNGIQHRKNCWQDGTPGTMCPIMPGTNYTYHFQPKDQIGSYFYYPTTGMHRAAGGYGGLRVNSRLLIPVPYADPEDDYTVLIGDWYTKSHTQLKKFLDGGRTIGRPDGIVINGKSGKGDGSDAPLFTLKPGKTYRVRICNVGVKTSINFRIQNHKMKLVEMEGSHVLQNDYDSLDVHVGQCFGTIVTANQEPKDYYMVASSRFLKTVITTTGLLRYEGGKGPASSQLPAGPVGWAWSLNQFRSFRWNLTASAARPNPQGSYHYGKINITRTIKLVNTQGKVDGKLRFALNGVSHTEPETPLKLAEYFGISDKVFKYDTITDDPTPEQIKNIKIEPNVLNITHRTFVEVVFENHEKSVQSWHLDGYSFFSVAVEPGTWTPEKRKNYNLLDAVSRHTVQVYPKCWAAILLTFDNCGMWNVRSENTERRYLGQQLYASVLSPEKSLRDEYNMPETSLQCGLVKNTPKPVNPYAGA
Function: Probable oxidase that may be involved in pollen tube growth. Sequence Mass (Da): 62131 Sequence Length: 555 Subcellular Location: Secreted EC: 1.10.3.-
P29162
MGSGKVTFVALLLCLSVGVIAEDPYLYFNWNVTYGTIAPLGVPQQGILINGQFPGPRINCTSNNNIVVNVFNNLDEPFLFTWNGVQHRKNSWQDGTPGTMCPIMPGQNFTYRFQVKDQIGSYSYFPTTALHRAAGGYGALNVHSRALIPVPFDNPADEYNVFVGDWYNKGHKTLKKILDGGRTIGRPDGIIINGKSAKVGEAKEPLFTMEAGKTYRYRFCNLGMRSSVNIRFQGHPMKLVELEGSHTVQNIYDSLDLHVGQCLSVLVTADQEPKDYYLVVSSRFLKQALSSVAIIRYANGKGPASPELPTPPPENTEGIAWSMNQFRSFRWNLTASAARPNPQGSYHYGQINITRTIKIFNSMSQVGGKLRYGLNGISHTNGETPLKLVEYFGATNKAFKYDLMADEAPADPSKLTIATNVKNATYRNFVEIIFENHEKTIRTYHLDGYSFFAVAVEPGRWSPEKRKNYNLVDGLSRNNIQVYPNSWAAIMLTFDNAGMWNLRSEMWEKTYLGEQLYFSVLSPSRSLRDEYNIPDNHPLCGIVKGLSMPAPYKA
Function: Probable oxidoreductase that may be involved in pollen tube growth. Sequence Mass (Da): 62034 Sequence Length: 554 Subcellular Location: Secreted EC: 1.10.3.-
Q8LPL3
MAVIVWWLLTVVVVAFHSASAAVVESTWEVEYKYWWPDCKEGIVMAINGQFPGPTIDAVAGDTVIIHVVNKLSTEGVVIHWHGIRQKGTPWADGAAGVTQCPINPGETFTYKFIVDKAGTHFYHGHYGMQRSSGLYGMLIVRSPKERLIYDGEFNLLLSDWWHQSIHAQELALSSRPMRWIGEPQSLLINGRGQFNCSQAAYFNKGGEKDVCTFKENDQCAPQTLRVEPNRVYRLRIASTTALASLNLAVQGHQLVVVEADGNYVAPFTVNDIDVYSGETYSVLLKTNALPSKKYWISVGVRGREPKTPQALTVINYVDATESRPSHPPPVTPIWNDTDRSKSFSKKIFAAKGYPKPPEKSHDQLILLNTQNLYEDYTKWSINNVSLSVPVTPYLGSIRYGLKSAYDLKSPAKKLIMDNYDIMKPPPNPNTTKGSGIYNFAFGIVVDVILQNANVLKGVISEIHPWHIHGHDFWVLGYGEGKFKPGIDEKTFNLKNPPLRNTVVLYPFGWTAIRFVTDNPGVWFFHCHIEPHLHMGMGVVFVEGVDRIGKMEIPDEALGCGLTRKWLMNRGRP
Cofactor: Binds 4 Cu cations per monomer. Function: Ascorbate oxidase involved in a redox system involving ascorbic acid (AsA) . The oxidation of AsA represses responses to high salinity and oxidative stress conditions such as vegetative growth and seed production reductions . Negative regulator of defense responses toward incompatible Turnip mosaic virus (TuMV strain UK1) by preventing jasmonic acid (JA)- dependent accumulation of ascorbic acid (AsA, AS) and dehydroascobic acid (DHA) . Catalytic Activity: 4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical Sequence Mass (Da): 64266 Sequence Length: 573 Pathway: Cofactor degradation; L-ascorbate degradation. Subcellular Location: Secreted EC: 1.10.3.3
M4DUF2
MGMWWIVAVAILAHTASAAVREYAWEVEYKFGWPDCKEGMVMAVNGQFPGPTIHALAGDTIVVHLTNKLATEGLVIHWHGIRQLGSPWADGAAGVTQCAISPGETFTYNFTVDKPGTHFYHGHYGMQRSAGLYGSLIIDVAKGKKEPLRYDGEFNLLLSDWWHEDVLSQEIGLSSRPMRWIGEAQSILINGRGQFNCSLAAQFSSTSLPTCTFKEGDQCAPQRLHVEPNKTYRIRLASSTALASLNFAVQGHKLVVVEADGNYITPFTTDDIDIYSGETYSVLLTTDQDPSQNYYITAGVRGRKPNTPPALTVLNYVTAPSSQLPTSPPPETPRWNDFDRSKNFSKKIFAAMGSPSPPETFDERLILLNTQNLIEGFTKWAINNVSLAVPGTPYLGSVKYNLRTGFNRSSPPKDYPVDYDIMTPPRNRNAKQGNVSCVFPFNVTVDVILQNANGLNANASEIHPWHLHGHDFWVLGYGEGKFKPGVDEKTYNLKNPPLRNTVALYPYGWTALRFVTDNPGVWFFHCHIEPHLHMGMGVVFAEGLNRIGKVPDEALGCGLTKQFLMNRNNP
Cofactor: Binds 4 Cu cations per monomer. Function: Ascorbate oxidase involved in a redox system involving ascorbic acid (AsA) . The oxidation of AsA represses responses to high salinity and oxidative stress conditions such as vegetative growth and seed production reductions (By similarity). Negative regulator of defense responses toward incompatible Turnip mosaic virus (TuMV strain UK1) by preventing jasmonic acid (JA)- dependent accumulation of ascorbic acid (AsA, AS) and dehydroascobic acid (DHA) . Catalytic Activity: 4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical Sequence Mass (Da): 63250 Sequence Length: 570 Pathway: Cofactor degradation; L-ascorbate degradation. Subcellular Location: Secreted EC: 1.10.3.3
A0A2S1XB67
MIKKVPIVLSIFCFLLLLSSSHGSIPEAFLNCISNKFSLDVSILNILHVPSNSSYDSVLKSTIQNPRFLKSPKPLAIITPVLHSHVQSAVICTKQAGLQIRIRSGGADYEGLSYRSEVPFILLDLQNLRSISVDIEDNSAWVESGATIGEFYHEIAQNSPVHAFPAGVSSSVGIGGHLSSGGFGTLLRKYGLAADNIIDAKIVDARGRILDRESMGEDLFWAIRGGGGASFGVIVSWKVKLVKVPPMVTVFILSKTYEEGGLDLLHKWQYIEHKLPEDLFLAVSIMDDSSSGNKTLMAGFMSLFLGKTEDLLKVMAENFPQLGLKKEDCLEMNWIDAAMYFSGHPIGESRSVLKNRESHLPKTCVSIKSDFIQEPQSMDALEKLWKFCREEENSPIILMLPLGGMMSKISESEIPFPYRKDVIYSMIYEIVWNCEDDESSEEYIDGLGRLEELMTPYVKQPRGSWFSTRNLYTGKNKGPGTTYSKAKEWGFRYFNNNFKKLALIKGQVDPENFFYYEQSIPPLHLQVEL
Function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vinblastine, catharanthine, tabersonine, vincadifformine, vindoline, vincristine, quinine and strychnine) biosynthesis pathway. Converts O-acetylstemmadenine (OAS) to reactive acetylated intermediates, likely dihydroprecondylocarpine acetate. Catalytic Activity: O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate Sequence Mass (Da): 59214 Sequence Length: 529 Pathway: Alkaloid biosynthesis. Subcellular Location: Endoplasmic reticulum EC: 1.21.3.-
P37064
SQIRHYKWEVEYMFWAPNCNENIVMGINGQFPGPTIRANAGDSVVVELTNKLHTEGVVIHWHGILQRGTPWADGTASISQCAINPGETFFYNFTVDNPGTFFYHGHLGMQRSAGLYGSLIVDPPQGKKEPFHYDGEINLLLSDWWHQSIHKQEVGLSSKPIRWIGEPQTILLNGRGQFDCSIAAKYDSNLEPCKLKGSESCAPYIFHVSPKKTYRIRIASTTALAALNFAIGNHQLLVVEADGNYVQPFYTSDIDIYSGESYSVLITTDQNPSENYWVSVGTRARHPNTPPGLTLLNYLPNSVSKLPTSPPPQTPAWDDFDRSKNFTYRITAAMGSPKPPVKFNRRIFLLNTQNVINGYVKWAINDVSLALPPTPYLGAMKYNLLHAFDQNPPPEVFPEDYDIDTPPTNEKTRIGNGVYQFKIGEVVDVILQNANMMKENLSETHPWHLHGHDFWVLGYGDGKFSAEEESSLNLKNPPLRNTVVIFPYGWTAIRFVADNPGVWAFHCHIEPHLHMGMGVVFAEGVEKVGRIPTKALACGGTAKSLINNPKNP
Cofactor: Binds 4 Cu cations per monomer. The Cu cations are bound as 3 distinct Cu centers known as type 1 or blue, type 2 or normal, and type 3 or coupled binuclear. Function: May be involved in a redox system involving ascorbic acid. Catalytic Activity: 4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical Sequence Mass (Da): 61704 Sequence Length: 552 Subcellular Location: Secreted EC: 1.10.3.3
Q40588
MASLGFLFFFLLPLILLELSSSRSVMAAKTRHFKWDVEYIHWSPDGEESVVMGINGQFPGPTIRAKAGDTVAVHLTNKLHTEGVVIHWHGIRQIGTPWADGTAAISQCAINPGETFLYRFKVDKAGTYFYHGHYGMQRSAGLYGSLIVEVGEGEKEPFHYDGEFNLLLSDWWHKGSHEQEVDLSSNPLRWIGEPQTLLLNGRGQYNCSLAARFSKPPLPQCKLRGGEQYAPQILRVRPNKIYRLRVASTTALGSLSLAIGGHKMVVVEADGNYVQPFSVQDMDIYSGESYSVLFKTDQDPTKNYWISINVRGREPKTPQGLTLLNYLPNSASKFPTLPPPIAPLWNDYNHSKSFSNKIFALMGSPKPPPQNHRRIILLNTQNKIDGYTKWAINNVSLVLPTQLYLGSIRYGINAFDTKPPPDNFPKDYDVLKQAPNSNSTYGNGVYMLKFNTTIDIILQNANALAKDVSEIHPWHLHGHDFWVLGYGEGKFSEKDVKKFNLKNPPLRNTAVIFPFGWTALRFVTDNPGVWAFHCHIEPHLHMGMGVIFAEGVHLVKKIPKEALACGLTGKMLMSNKHN
Cofactor: Binds 4 Cu cations per monomer. Function: May be involved in a redox system involving ascorbic acid. Catalytic Activity: 4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical Sequence Mass (Da): 64865 Sequence Length: 578 Subcellular Location: Secreted EC: 1.10.3.3
Q03168
MLIKSIIALVCLAVLAQADFVRVQLHKTESARQHFRNVDTEIKQLRLKYNAVSGPVPEPLSNYLDAQYYGAITIGTPPQSFKVVFDTGSSNLWVPSKECSFTNIACLMHNKYNAKKSSTFEKNGTAFHIQYGSGSLSGYLSTDTVGLGGVSVTKQTFAEAINEPGLVFVAAKFDGILGLGYSSISVDGVVPVFYNMFNQGLIDAPVFSFYLNRDPSAAEGGEIIFGGSDSNKYTGDFTYLSVDRKAYWQFKMDSVKVGDTEFCNNGCEAIADTGTSLIAGPVSEVTAINKAIGGTPIMNGEYMVDCSLIPKLPKISFVLGGKSFDLEGADYVLRVAQMGKTICLSGFMGIDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFATAV
Function: May degrade organelles involved in the biosynthesis and secretion of vitellogenin. Sequence Mass (Da): 41790 Sequence Length: 387 Subcellular Location: Lysosome EC: 3.4.23.-
O07002
MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSGAFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSLISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANFIISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPIVSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSLPFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVNKDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKDLNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKEDVSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKYTGLPKAAIDYDK
Function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56989 Sequence Length: 520 Subcellular Location: Cell membrane
P83712
NVVVLATGGTIAGAGTNAFASQXGPLGMVVEGK
Catalytic Activity: H2O + L-glutamine = L-glutamate + NH4(+) Sequence Mass (Da): 3099 Sequence Length: 33 Subcellular Location: Periplasm EC: 3.5.1.38
P10182
KEVENQQKLANVVILATGGTIAGAGASAANSATYQAAKVGVDKLIAGVPELADLANVRGEQVMQIASESITNDDLLKLGKRVAELADSNDVDGIVITHGTDTLEETAYFLDLTLNTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASNKDSRGKGVLVTMNDEIQSGRDVSKSINIKTEAFKSAWGPLGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYSYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRLTPALQTLRKTGTQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPEKARILVELAMVKTQDSKELQRIFWEY
Catalytic Activity: H2O + L-glutamine = L-glutamate + NH4(+) Sequence Mass (Da): 36200 Sequence Length: 337 Subcellular Location: Periplasm EC: 3.5.1.38
O60020
MISDTVIAILAVALVGSTVQAAPVDATATSTSGIIAVPISKSAAQLAREADPVVSLDWLKKTKAQAQYKHKQANARLHSKRATGASVLTDQGSESLWTGPITIGGQSFTVDWDTGSSDLWVPSSACSSAACNAHHKYTLTSTGKKQSGTFSISYGDGSSASGPVYKDNVVASGLQATSQVFGAVTSESSSFSSDPSDGISGLGWPALAQLSGTSYFWSLINQGTVTSPVFSFRLATTNSELYLGGINSAHYTGAITYTPVTQKAYWTIALGGVSVNGAAINPSVSSAIIDTGTTLVYGPTAGVAALYAKIPGSASMADTYGSDYQGYYTFPCSAVPTVALTFGGSSFSVPTSAFNLGTVSSGSKQCVGGIVGQGDGSWLVGDVFLQGVYSIYDVGNARVGFAKTV
Function: Possesses acidic protease activity. Hydrolyzes casein and azoalbumin in vitro. Sequence Mass (Da): 41370 Sequence Length: 405 Subcellular Location: Secreted EC: 3.4.23.-
O04057
MASYHSKAAFLCLFLLVSFNIVSSASNDGLLRVGLKKIKLDPENRLAARVESKDAEILKAAFRKYNPKGNLGESSDTDIVALKNYLDAQYYGEIAIGTPPQKFTVIFDTGSSNLWVLCECLFSVACHFHARYKSSRSSSYKKNGTSASIRYGTGAVSGFFSYDNVKVGDLVVKEQVFIEATREPSLTFLVAKFDGLLGLGFQEIAVGNAVPVWYNMVEQGLVKEPVFSFWLNRNVEEEEGGEIVFGGVDPKHYRGKHTYVPVTQKGYWQFDMGDVLIDGEPTGFCDGGCSAIADSGTSLLAGPTPVITMINHAIGAKGVVSQQCKAVVAQYGQTIMDLLLSEADPKKICSQINLCTFDGTRGVSMGIESVVDENAGKSSDSLHDGMCSVCEMTVVWMQNQLRQNQTKERIINYINELCDRMPSPMGQSAVDCGQLSSMPTVSFTIGGKIFDLAPEEYILKVGEGPVAQCISGFTAFDIPPPRGPLWILGDVFMGRYHTVFDFGKLRVGSAEAA
Function: Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles. Sequence Mass (Da): 55856 Sequence Length: 513 Subcellular Location: Vacuole EC: 3.4.23.-
P42210
MGTRGLALALLAAVLLLQTVLPAASEAEGLVRIALKKRPIDRNSRVATGLSGGEEQPLLSGANPLRSEEEGDIVALKNYMNAQYFGEIGVGTPPQKFTVIFDTGSSNLWVPSAKCYFSIACYLHSRYKAGASSTYKKNGKPAAIQYGTGSIAGYFSEDSVTVGDLVVKDQEFIEATKEPGITFLVAKFDGILGLGFKEISVGKAVPVWYKMIEQGLVSDPVFSFWLNRHVDEGEGGEIIFGGMDPKHYVGEHTYVPVTQKGYWQFDMGDVLVGGKSTGFCAGGCAAIADSGTSLLAGPTAIITEINEKIGAAGVVSQECKTIVSQYGQQILDLLLAETQPKKICSQVGLCTFDGTRGVSAGIRSVVDDEPVKSNGLRADPMCSACEMAVVWMQNQLAQNKTQDLILDYVNQLCNRLPSPMGESAVDCGSLGSMPDIEFTIGGKKFALKPEEYILKVGEGAAAQCISGFTAMDIPPPRGPLWILGDVFMGPYHTVFDYGKLRIGFAKAA
Function: Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles. Catalytic Activity: Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-|-Asp- and -Asp-|-Asp- bonds in 2S albumin from plant seeds. Sequence Mass (Da): 54226 Sequence Length: 508 Subcellular Location: Vacuole EC: 3.4.23.40
C0HJJ8
GTQTNAPWGLARLIS
Function: Protease capable of hydrolyzing gelatin and cell surface heparan sulfate proteoglycans (HSPGs) in vitro. Sequence Mass (Da): 1585 Sequence Length: 15 Subcellular Location: Secreted EC: 3.4.21.-
E3PJ88
MSIKQMPGRVLISLLLSVTGLLSGCASHNENASLLAKKQAQNISQNLPIKSAGYTLVLAQSSGTTVKMTIISEAGTQTTQTPDAFLTSYQRQMCADPTVKLMLTEGINYSITINDTRTGNQYQRKLDRTTCGIVKA
Function: Part of a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane (Probable). Required for correct assembly of the type II secretion system-beta (T2SS-beta), for localization of GspD-beta to the cell outer membrane and for export of a labile enterotoxin by T2SS-beta . Each AspS2 binds to 2 GspD2 subunits and may clamp the monomers together, stabilizing structure and accelerating its assembly . Location Topology: Lipid-anchor Sequence Mass (Da): 14670 Sequence Length: 136 Subcellular Location: Cell outer membrane
Q8L3K8
MNAIGNFLVGTPVFTIFICLALGYLLGKLKIGSFTLGATVGVLIVALLIGQLGVFPRDTLLGDIFFDFFMFAIGYRVGPSFISSMKKFGAKIVYATLIFLVSAFIVAYACFKMFHIGPGIAAGIIAGGLTQSAVIGSSLETISKLPISDHLKTLYSNQIPIVYTLTYVFGTIGVLIFLRDIMPKLMHIDLKKQAVKTAKELDMIPVPVIVASTHFYTINDGSSLIGQTLGTVNTKFAKGLVAAGLNDSADMASVINAGDVLAISGGIDEIGRAVQEFNLLEVTGKTKAYVSKQVVLKKNFSADVLKNAQDKGVLVATLAGDVMDPAQFSTLKPAESVTLVGQKDAVSEVQSQLGRLRAAENIINYSWFALGIALSAALGIVGTKVSGVPIALGGGTASLIVGLVQSIYRDKHAHMDTIPDSLLEFFQSIGLNLFIATVGLSAAKTFISAIQSMGISVLLIGAVISILPHIITFVICYYLMKMEPISIIGAQTGADTLSAALNDVSERVGSDASPFFAAAVAPAYAIGNIFLTLMGPIFIVLLS
Function: Catalyzes the electrogenic exchange of aspartate with alanine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 57213 Sequence Length: 543 Subcellular Location: Cell membrane
Q1QVN0
MSDVKKVVLAYSGGLDTSVIVKWLQETYDCEVVTFTADIGQGEEVEPARAKAQALGVKEIYIEDLREEFVRDYVYPMFRANTIYEGEYLLGTSIARPLIAKRLVEIANETGADAISHGATGKGNDQVRFELGAYALKPGVKVIAPWREWDLNSREKLMNYCEEHDIPVDFSTSKKKSPYSMDANLLHISYEGGILEDPWAEAEEDMWRWSVSPEAAPEQPTYVELTFDKGDIVAIDGEPLKPHEVLSRLNRMGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLRAHRAIESLTLDREAAHLKDELMPKYAEVIYNGYWWSPERKMLQAAIDATQDNVNGVVRMKLYKGSATVVGRKSEQSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAAGKGRQAD
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 45409 Sequence Length: 406 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
C1FU68
MKEKVVLAYSGGLDTSIIIPWLKENYDLDVIAVCVNVGQGDDMDYVKTKAIKSGASKIYVEDVKEEFVVDYLYKAIKSEALYEQDYMLGTSFARPLMAKKLVEIAHKEQAKYICHGCTGKGNDQVRFEVGVKAQDPIIKIIAPWRIWDIKSREDAIDYAKKVGVEVPVTKKKIYSVDKNLWHVSHEGGDLEDLKNEHKEDMYFMVTPPEKAKNEPTYLEIYFEKGAPVKINGEVLNPVDIIDKLNTIGGENGIGIADIIENRLVGMKSRGIYETPAGTLLYAAHKKLESVTLDKYTYQYKKIVSAQYGELVYNGLWFTSLREAIDAFVDKTQENVTGTVQLKLYKGNIKPCSVDTEYALYDEGISSFGESELYSHKDAEGFINLFGLPSKIKALKNF
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 44742 Sequence Length: 397 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
Q186Z6
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYAEKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVALIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 44624 Sequence Length: 399 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
Q827Z1
MQCEEKPVTERVVLAYSGGLDTSVAIGWIAEETGAEVIAVAVDVGQGGEDLDVIRKRALACGAVEAEVADAKDEFADEYCLPAVKANALYMDRYPLVSALSRPTIVKHLVAAAQKHGATTVAHGCTGKGNDQVRFEAGIVALAPGLKCIAPVRDYAMTRDKAIAFCEEKRLPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDIYEYTSNPAEPREADEVVISFKEGVPVAIDGRPVTVLQAIQQLNERAGAQGVGRIDMVEDRLVGIKSREVYEAPGAIALITAHQELENVTVERELARYKRQVEQRWGELVYDGQWFSPLKRALEGFIDEANQHVNGDIRMTLHGGRAVVTGRRSETSLYDFNLATYDTGDSFDQAAAKGFIDIYSLSSKIAAKRDLA
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 44066 Sequence Length: 404 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
Q06734
MSKVLTSLPAGERVGIAFSGGLDTSVAVAWMRDKGAVPCTYTADIGQYDEPDIASVPSRASAYGAEITRLVDCRAALVEEGLAALACGAFHIRSGGRPYFNTTPLGRAVTGTLLVRAMLEDGVQIWGDGSTFKGNDIERFYRYGLLANPHLRIYKPWLDADFVTELGGRKEMSEWLLAHGLPYRDSTEKAYSTDANIWGATHEAKTLEHLDTGIETVDPIMGVRFWDPSVEIATEDVTVGFEQGRPVSINGKEFASAVDLVMEANAIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIVYERLVNAIHNEDTLAAYHNEGRRLGRLMYEGRWLDPQALMIRESLQRWVGTAVTGEVTLRLRRGEDYSILDTTGPAFSYHPDKLSMERTEDSAFGPVDRIGQLTMRNLDIADSRARLEQYVGLGLVGTPHPTPIGAAQAAATGLIGAMDEGGAEAIASRGEATDEETMLDRAAMESGTD
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 52383 Sequence Length: 482 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
Q04MW7
MSKEKVILAYSGGLDTSVAITWLKKDYDVVAVCMDVGEGKDLDFIHDKALKVGAVESYVIDVKDEFATDYVLVAHQSHAYYEQKYPLVSALSRPLISKKLVEIAHQIGATTIAHGCTGKGNDQVRFEVSIAALDLNLKVIAPVREWKWSREEEIYYAKENGVPVPADLDNPYSVDQNLWGRANECGILENPWNQAPEEAFGITTSPEQAPDMPEYIEIEFSEGVPVSLNGEVLKLADLIQKLNEIAGKHGVGRIDHVENRLVGIKSREIYECPGAVTLLTAHKEIEDLTLVREVAHFKPIIENELSNLIYNALWFSSATQALIAYIKETQKVVNGTAKVKLYKGSAQVVARKSPSSLYDENLATYTSADTFDQDAAVGFIKLWGLPTKVHSEVQKSAK
Catalytic Activity: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Sequence Mass (Da): 44065 Sequence Length: 398 Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Subcellular Location: Cytoplasm EC: 6.3.4.5
Q87Q40
MTKSLFRQSFLTDTLDVHIDVAPAEQVLSNGVQLKLYQRGVLEVIPENPTQETKNIIISCGIHGDETAPMELVDSIIKDIESGFQKVDARCLFIIAHPESTLAHTRFLEENLNRLFDEKEHEPTKELAIADTLKLLVRDFYQDTEPKTRWHLDLHCAIRGSKHYTFAVSPKTRHPVRSKALVDFLDSAHIEAVLLSNSPSSTFSWYSAENYSAQALTMELGRVARIGENALDRLTAFDLALRNLIAEAQPEHLSKPCIKYRVSRTIVRLHDDFDFMFDDNVENFTSFVHGEVFGHDGDKPLMAKNDNEAIVFPNRHVAIGQRAALMVCEVKTRFEEGELVYD
Cofactor: Binds 1 zinc ion per subunit. Function: Transforms N(2)-succinylglutamate into succinate and glutamate. Catalytic Activity: H2O + N-succinyl-L-glutamate = L-glutamate + succinate Sequence Mass (Da): 38837 Sequence Length: 342 Pathway: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. EC: 3.5.1.96
Q2UEK7
MLPTLPNIAGRINTMATFLLPVAIGTIILLFLYGKYVTSTLIPGPPTLPLIGNLHQLPSDDRRHVLAQWHKKHGPIISLKFGWSSVVILGNIAVTKELFGKRSLKYGSRPRMVMARDCMTKQMQTSTLPWGEKWKIHNRIQLSLVGGPKIRSYQSLLDIESCKVLYQLLSTESLVTCFNRFKFNIIYTLAYGKDPDQNESDFHEILELADHFTQTLTNATWVVDLFPILNCLPRRLAPWKAVGDDFHRRAMGWFRRNSEAAVKSNSWNWTKHVQFNEDTGNLSVSEMQYLIGVLFEAGVDSTATVLHFFVLACTLYPDAVTKARQELDKVVGSARLPTPKDLPQLPYVKAFIQEVLRWRPITAEGLPHFTLEDDKYQGYDIPKGSTVIFNYWSGHMDEDTYQHADQFCPERWIERPDLPLGVFGYGRRACAGRRLALMSLETLIPKLLWAFDFRSPAGTDHGKSRDPGTEHQGALIKPRSFPVSWHPVSNDRRLIIERLFQERDKDLDTVLDDIGKAFERY
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities . The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate . Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK . Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE . The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin . The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively . Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B . Location Topology: Single-pass membrane protein Sequence Mass (Da): 59544 Sequence Length: 521 Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. Subcellular Location: Membrane EC: 1.-.-.-
Q2UEK8
MGEQTEFEPIQLSPLDQAIPPVYIRILLCFSVVNVDRAISQLQTGVSSLLSALPFLSGDVVRYTAPGKTKWLYQLCPPTHQVQATGVLVVKHHQMRCMVDEKRFAPSSTSHIPLSPFAEPARPAPIFRVQANAYIDGITLGFAFHHIAVDATGMGVIISELARHCRSSPPPSLLCPDYERATRQLISNSRATECSGLDHSGDYISCQALSPPAEGSEDASPSIEISTETRTFVFPAARLESLKNACIEMLPTLDQQQRQQNPCLDEPARTKVPWLSTNDVFVALLWVCLTRCRYQEDQNSGLPSDEHTRICMGVNMRSRIQPPLSADYLGNAILSLSFKLNVNVFRRTQVTNESIEGVDSKDIEHKQWLATICRVARNIRRGVNGMDDSYFRSVVSFLEDSSDCRLFDYARCDFCVPSWRHLCVYHADFGEMGRPKSLEVFDVPGDGSFCILPQHYGAAAPWELLLGLLKA
Function: O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities . The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate . Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK . Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE . The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin . The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively . Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B . Sequence Mass (Da): 52449 Sequence Length: 471 Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 2.3.1.-
P80358
MIVRPVTSADLPALIELARSTGTGLTTLPANEQRLQHRVSWAEKAFRGEAERGDADYLFVLEDDAGKVVGISAIAGAVGLREPWYNYRVGLTVSASQELNIHREIPTLFLANDLTGNSELCSLFLHADHRSGLNGKLLSRARFLFIAEFRHLFGDKLIAEMRGMSDEEGRSPFWESLGRHFFKMEFSQADYLTGVGNKAFIAELMPKFPLYTCFLSEEARGVIGRVHPNTEPALAMLKAEGFSYQGYVDIFDAGPAIEAETDKIRAIAESQNLVLAVGTPGDDAEPYLIHNRKREDCRITAAPARAAAGTLVVDPLTAKRLRLSAGASVRAVPLSAQKRG
Catalytic Activity: L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine Sequence Mass (Da): 37245 Sequence Length: 340 Pathway: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5. EC: 2.3.1.109
Q2UEK9
MTDISTGVQLKPGIGDGTVYNGNMSKDTLVNCSPDPENPEKGQASSPRTQISVDDNEESTTEYPSSWKLAMIMISLCLAVFCLALDTTIMATAIPKIADQFNSLNDVGWYGSAYLLTTSALTLSFGKLYSFYSIKWVYLQALGMFEIGSLICGATPNSLGLIIGRAIAGSGSAGIYSGSMLIVARSAPLERRPLLTGILGGLFGVASVVGPLIGGAFTDNLSWRWCFYINLPLGAVTGLFLILFFDGAKATTQRATIRDQLSQLDLLGSLCFLPAIICVLLALQWGGTTYPWHDGRIIALFTVFGVLLLAFAGVQWWRQEKATVPPRLIANRNVWGAALFSFCLNASFIIFTYYLPMWFQSIKGVTATQSGIMNLPMVLAVVIFSIISGGLVGALGYYTPFMVIAPLIAAIGAGLLSTLRMDSNNASWIGYQILYGVGVGCGLQQPIVAVQGSLAPADLPTGTVIVMFMQTIGGAIFMSVGQNVFQNQLMRNLATQAPSVDAARVLQAGATMLRKTVSSDLLPAALRAYNSAITEAFYVAVAMAVLALPGALVMQWISVKGRQL
Function: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities . Seems not to be involved in astellolides translocation . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60176 Sequence Length: 564 Subcellular Location: Membrane
Q2UEL0
MTRQSHYQAIILDLGNVVFEWDTSQNPPTAAPNQISLLRTSMKSPVYHSYERGQLSTEECHRLLGESLHVDPGQIKEAFDLARQSLRSNPALLDFIRQLKQTRGVAVYAMSNIPQAEIEYLKESRAGDMEVFDEVFASGYVGSRKPETEFYRRVMGEIGLKAERVVFVDDKEENVDVARGLGLYGVCFGGVEELRGHLLGI
Function: Sesquiterpene phosphatase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities . The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate . Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK . Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE . The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin . The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively . Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B . Sequence Mass (Da): 22610 Sequence Length: 201 Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 3.1.3.-
Q2UEL1
MSRRFPIQVAQSEIPPIAWGLWRMVYRLWLHPLSGYPGPRLAAVSNLPYFAWTCTGNLHLRLQELHKVYGDVIRIRPNALTYRTPEAWTDIYGHRKPGTLPFSKDPEFFMPAQAGSSHMINANEKDHTRQKRLLNHAFSERSLRQQEHLIMGYIDLFIQRLRGQARMGAETVNMEEWLNFLTFDIIGDLAFGEPFGCLQNSEYHPWVATIFKSIKTGAILRALNIYPILLGFIRRFLPKSLVQKRIAHYQMSKDRVTRRLQTETSRPDFISYILKYNDDRGMSTPEIEMNAALLIQAGSETTATVLAACLYFLQKNAACHRRLVQDIRSAFTQETDINFLSAAQLPYMNGVIEESLRLFPPAPGIGPRVVPKGGARICGRYVPGGVSVSVGHYSTFRSARNFTRPNEFLPQRWLDRDAESEFASDQTMALQPFSYGPRACIGRNLAYAEMRTILAKILWHFDVQLDERSADWANSKSYIVWEKGPLWLKLHPRNVPQETD
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities . The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate . Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK . Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE . The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin . The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively . Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B . Sequence Mass (Da): 57391 Sequence Length: 500 Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 1.-.-.-
P42662
MDLKMLLIFTAFLLPAVLGFPIQDNYENSTATSESTQVTTEESIYDSPSPTETDSEDDVIFNRILEVNKDSSRYLQEGDIVPRRSRSAFNCRNCYWPQSMDGIVRIPYVLDPTYEENHVRGILEAMAEFETLTCINFVKRKTERDYLIIRSADGCWSNYGKVGGGQTVSVMKGGCMWKGIIQHELDHALGFLHEHSRSDRDKYVKIMWEYISPACRPDFRKFENSNNLGLPYDYSSVMHYGPHTFTNTTGKATIVPVPDGSVHIGQRLGLSNLDVAKINKLYNCSRCSTIIDAAFGSLKSANYPRNYSDNTNCVWLIRTRSRKISLHFRDFDLRRTRGCQGDYVKVYDGSSKYSPVLMNKTCGSQIPTDVVSSSSLMLIEFVTDGRDTASGFQATFTSARMQRRFNTRN
Cofactor: Binds 1 zinc ion per subunit. Function: Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization (By similarity). Protease which may play a role in the breaking down of the vitelline membrane (days 0-5) and possibly, in the digestion of the egg white (days 9-12) . Sequence Mass (Da): 46446 Sequence Length: 409 Subcellular Location: Cytoplasm EC: 3.4.24.-
P33879
MSKETKKPFRQSVAEWRQFVYNPNSGEFLGRTAKSWGLILLFYLVFYGFLAALFTFTMWVMLQTLSNDIPKYRDRISSPGLMISPKPDTALEFYFNKSDAQSYAEYVSTLRKFLETYDDSKQSQNINCTPGKVFDQNDVAVKKACRFNLSELGQCSGKEDKTFGYSKGTPCVLVKMNRIIGLKPEGEPYIQCTSKEPGAVEINYFPSGGLIDLMYFPYYGKTLHAHYLQPLVAVQLAINSNSTNEEIAIECKILGSPNLKNEDDRDKFLGRIAFKVEMTE
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31859 Sequence Length: 280 Subcellular Location: Cell membrane
P54709
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31513 Sequence Length: 279 Domain: The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties. Subcellular Location: Apical cell membrane
Q63377
MTKTEKKSFHQSLAEWKLFIYNPTSGEFLGRTSKSWGLILLFYLVFYGFLAALFTFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPPTALDYTYSMSDPHTYKKFVEDLKNFLKPYSVEEQKNLTDCPGGALFHQEGPDYSACQFPVSLLQECSGVNDSNFGYSKGQPCVLVKMNRIIELVPDGAPYITCITKEENIANIVTYPDDGLIDLKYFPYYGKKRHVGYRQPLVAVQVIFGADATKKEVTIECQIDGTRNLKNKNERDKFLGRVSFKVIAHA
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31830 Sequence Length: 279 Domain: The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties. Subcellular Location: Apical cell membrane
P30716
MAKEENKSGEQSSSEWKQFIYNPSSGEILGRTASSWALILLFYLVFYGFLAGLFTLTMWVMLQTLDDSVPKYRDRVSFPGLMISPKSAGLEISFSKSDKSHMKSILKFFTHFYHHTMTPYKLQMCSARKAITTEQEGVEEKKSCQFNRSSLGPCAGLEGNEYFGYNDGSPCVLVKMNRIIGLKPDGNPHINCTSKAENISLQYYPEYGKIDLMYYPYYGKKTHVNYVQPLVAVKITPSNSTGTSEIVLECKLYGSPNLKNNDDRDKFLGRVNFKLEIKD
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of this glycoprotein is not known. Some specific sequence of the beta subunit can modulate the activation of the Na,K-pump by extracellular potassium ions. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31678 Sequence Length: 279 Subcellular Location: Cell membrane
P21188
MAKEENKGSEQSGSDWKQFIYNPQKGEFMGRTASSWALILLFYLVFYGFLAGLFTLTMWVMLQTLDDSVPKYRDRVSSPGLMISPKSAGLEIKFSRSKTQSYMEYVQTLNTFLAPYNDSIQAKNEFCPPGLYFDQDEEVEKKTCQFNRTSLGICSGIEDPMFGYGEGKPCVIVKINRIIGLKPEGNPKINCTSKTEDVNLQYFPDNGKIDLMYFPYYGKKTHVNYVQPVVAVKISPSNFTSEEIAVECKIHGSRNLKNEDERDKFLGRVTFKVKITE
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31570 Sequence Length: 277 Subcellular Location: Cell membrane
Q2HZ96
MEPGMEMNTASEGGTRRGPENKHEEKVQDPNRGEAETKAEMGNKTWADLAGEMKTFLWNPEERTCMGRTAKSWGLILLFYFIFYTCLAGMFAFCMYVMLLTLSPYTPTYRDRVSPPGVMIRPYLNGFTIAFNVSKPSTWQPYVDSMHQFLAAYDDKVQEEKNIECISGQYFIQGGNDSEEKKACQFKRSLLQNCSGIEDPTFGFSKGQPCILLKMNRIIGYRPGAGVPVNVDCKVQKGNESDLRSVDFYPGNGTFDLMYYPYYGKLTHVNYTSPLVAMHFTDVKRNSLVHIQCKLNGKGIINDVNSDRFLGRIIFTLSIGK
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. PTM: Glycosylated. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 36363 Sequence Length: 321 Subcellular Location: Membrane
Q9UN42
MRRQLRSRRAPSFPYSYRYRLDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIET
Function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 41598 Sequence Length: 357 Subcellular Location: Nucleus inner membrane
Q202B1
MATTAGEQANYLQSADSMSDGRQHHPEEAGEKKQEEQKKSWGEWLQDLKIFIWNPEKKEVLGRDKKSWALILLFYFILYCFLAGLFALCIYGLLATISPYVPTYRDRVFPPGLTIRPQFNALYFSFNPSDRSTWSSHAESLNTFLEDYNDEIQQEKNLECTPGKYFFQPGEDHEERKACQFRRSLLKNCSGIEDPTFGFAQGKPCILLKMNRIVGYQAGSGIPIYVTCEILKADASYLGPVNFYPSDKFDLMYYPYYGKLTHVNYTSPLIAMQFTEVKNNQDINIQCKINGKDIISDHDKDRFLGRVAFTLHIG
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. PTM: Glycosylated. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 36129 Sequence Length: 314 Subcellular Location: Membrane
P28774
MAKGKQKKGKDLNELKKELDIDFHKIPIEECYQRLGSNPETGLTNAQARSNIERDGPNCLTPPKTTPEWIKFCKNLFGGFALLLWTGAILCFLAYGIEASSGNEDMLKDNLYLGIVLATVVIVTGIFSYYQENKSSRIMDSFKNLVPQYALALREGQRVTLKAEELTMGDIVEVKFGDRVPADLRVLEARSFKVDNSSLTGESEPQARSPEFTNDNPLETKNLAFFSTNAVEGTMRGIVIGIGDNTVMGRIAGLASGLDTGETPIAKEIAHFIHIITGVAVFLGVTFFIIAFVLGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDGTITEADTTEDQSGAQFDKSSAGWKALVKIAALCSRAEFKPNQSTTPILKREVTGDASEAAILKCVELTTGETEAIRKRNKKICEIPFNSANKFQVSIHENEDKSDGRYLLVMKGAPERILERCSTIFMNGKEIDMTEELKEAFNNAYMELGGLGERVLGFCDYLLPLDKYPHGFAFNADDANFPLTGLRFAGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSEVNPRDAKAAVVHGGELRDITPDALDEILRHHPEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIVYTLTSNIPEISPFLLFILFDIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRRPRNPVTDKLVNERLISLAYGQIGMIQASAGFFVYFVIMAECGFLPWDLFGLRKHWDSRAVNDLTDSYGQEWTYDARKQLESSCHTAYFVSIVIVQWADLIISKTRRNSVFQQGMRNNILNFALVFETCLAAFLSYTPGMDKGLRMYPLKINWWFPALPFSFLIFVYDEARKFILRRNPGGWVEQETYY
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Catalytic Activity: ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 110699 Sequence Length: 1004 Subcellular Location: Cell membrane EC: 7.2.2.13
A0A068BGA5
MASFPPSLVFTVRRKEPILVLPSKPTPRELKQLSDIDDQEGLRFQVPVIMFYKRKLSTEGEDPVKVIREALAEALAFYYPFAGRLIEGPNRKLMVDCTSEGVLFIEADADIELNQLIGDTIDPGTYLDELLHDVPGSEGILGCPLLLIQVTRFRCGGWAFAIRLNHTMSDTLGLVQFLTTIAEFTRGAEGAPSVPPVWQREFLAARQPPFIPFQHHEYEQVIDTTPDDNKKSMTHKSFFFGPKEIRAIRSHLPLHHRSTSSTFDVLTACLWRCRTCALVLDPKKTVRISCAASGRGKHDLHVPRGYYGNVSAFPATVLRAGMISTSPLEYAMEGVKKAKARMTGEYLRSVADLMVTKGRPLYTVVGNYIVSDMTRVGLDTIDFGWGKPVYGGPARAFPLISFYGRFKDNKGEDGIVVLICLPEAAMKRFQEELKKMTGEHVDGPFDYKPIKVVSKL
Function: Involved in the biosynthesis of volatile esters which confer kiwifruit flavor . Alcohol acyl transferase that can use a wide range of alcohols as substrate to produce esters . Exhibits benzoyl-CoA:alcohol O-acyltransferase activity . Catalytic Activity: 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA Sequence Mass (Da): 50972 Sequence Length: 456 EC: 2.3.1.-
A1L209
MKMEDMSLSGLDNTKLEALAHDVYSDLVEDACLGLCFEVHRAVKQGYFFLDETDQESMKDFEIVDQPGVDIFGQVYNQWKNKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIASSNNTSKSESDQEDNDDINDNDWSYGSEKKAKKRKSEKNPNSPRRSKSLKHKNGELSGSVNPDMYKYNYSSGISYETLGPEELRSILTTQCGVVSEHTKKMCTRSQRCPQHTDEQRRAVRVFLLGPSASTLPDADTMLENEAYEPPDGQLIMSRLHWDASSDISPSDSASSKASTNNSESKRPKKKKPSTLSLTPAGERDKAQERDRIAGSGSSGSSSQNALGLSSRKKRPKLAVPPAPSIYDDLN
Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Sequence Mass (Da): 40720 Sequence Length: 367 Domain: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. Subcellular Location: Nucleus
Q14CW9
MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN
Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B . The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex . Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B . Sequence Mass (Da): 38651 Sequence Length: 347 Domain: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. Subcellular Location: Nucleus
O14261
MRFRLNDSFSGKSWTIDNVQWTPQNLVAWIMELNIGLSDEAKLLLPNGMSLNETVLNSESDVVIYVLDQNLLTFTYDGDKIPSIPSLKGQPISNVLTGIIADSSSDQWKDKISKCLSLLSDILESSSKIHNQLSVCHDEYSTSIVSPEVAMNYLQRRQSGMKDLLFVFYERLDRVSVSDLLHDFLALPTGSLPITPLKILSTNWTKLDSWLNSISARYAEAQKRVQQCIGAANSIIVSPFKEVPSIKEGDDAYYHLRSVAQDAANILQEILKIESTSTTSQIKPKCNYETEITDCMEKLQSNLSELKSSRKSSLISLKSFWLSFYKVSLRYDALYEYLRQIAEELDRSKFVLSQSRNIFSLYIDILMEALRRTEWQESYNVSHDSSLPLDQEKELSLRKSWLSHFSNLLFNHGQLKYLPVLTRDEISNYLLNIQAHPNYQTFHQMLSNRLSEYLGFPGSPREAVSNTVQANNSLHEKLAMYQNRCNNLEAMLSHQNGFNYNINNDGLSPNAPHPPINEQSNSSQPFYRVSPSIVPLNVIRKLTNRKTSFTDSHILRLQDEVNQLRNELDLVNKRNEDLLIELQGKEEKIQYLETENEEVLQKYENLQEELSSTRKLLTKNEAAVAEQQSNEEMHSNEPNILNLYSVFEGKVDSLQELYNAFKLQLTSLKQKGEYATLAKDAEAVQHIIEERDYALAEKADLLKLSENRKEQCKILTQKLYTIVFRCNELQSVLRECVTQPGFDSDNERDGHASIPDRQIEFNSKDLQYLYWMDGEDADRNFQEFLNRMSSLDFDSFHNFVVSVLTQAHNHELRWKREFQSNRDKALKAILDSQSKVSLRNFKQGSLVLFLPTRRTAGNKKVWAAFNVNAPHYYLNTQPHLKLESRDWMLGRVTSIEDRTADDSTDKWLRLPSGTIWHLVEAIDERF
Function: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the preautophagosome (PAS), the site of vesicle/autophagosome formation. Required for atg9 anterograde transport from the mitochondria to the PAS (By similarity). Required for nitrogen starvation-induced sexual development and for entering the dormant G0 state (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 106770 Sequence Length: 926 Subcellular Location: Preautophagosomal structure membrane
Q6CFR0
MSEIRVSCASSGVSVSAARDQFSSLPHLKAWIELEFSVSVSEQLLLTVAAEQVKMAHLGTQNELFVFDRSVVGGTVSNEHKYSAPKLKTLTPGTDPSQWALTVLTHCSRLVEETKRVTAEIATIKRATNVAITQMKQHSQNLDKNLLNVKEYSKELNQGITPLLSVDLAQLRDNTRAVKLVAPAVFGKKQFLNDWLDLQQLQSIVVEFKADFPSCMDKLQTLEQDLAQLSKDTQTLVNSTDVWIGGTNSDVLCNEAVGILRKLSELTSGDHVTNEAVKSVQNCQSQILDLHKALSKAKFQTVQHSQKVLQSISQLQSRSTKLKPKLTHIGSELTKYEEKRVQAMKQVDVEFVYGCVLVEMLRRTVWSQSGGENGSVKSEIGTRVAWKKQFQDTFPFVDILNEQEDLTIDTISTSSPSIVHNLVIARPVVTDYISQVSSKEVRNNLESLLGGVTGSAAATSSFPRSLFRNGSISGSLMAERAPISSATNADDKIRGYEARIRKLEDLLYKQRMSQDTSRWSVSPGTPSAGFAVVSPGQLSSEARGSSLSPEPTETREQVKAREKAEEEARKAEEERLARDKAAAEALQSKVDQLSQSLLHTENEKNDLMANLASMESDFSRERRCLVQEISELKLRVEELEEQVETAAETSIERHQRADQETEELEQRLKAMTLAQNTVDDENSRLKITLQDMSQRLYTGYKRNCVLLESLGLQAQKEYDADGSEVVSFDIHRVKGLRKKHRGKKGEKTEKDSESDSTDDFSALYWATKTTPDSFESSYRTFLARIFLDYDLYVEKVAKRFEDLEHLARKLQKEARNYRTMTQQLDDETRSKIALNRFKVGDLVLFLPTRDPSRQPQPWAAFNVGAPHFFLKQKPGRELKDRDWLVGRITGMEERVVNGGIGDREENPFDLGQGLRWWWLEAEEE
Function: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 104021 Sequence Length: 924 Subcellular Location: Preautophagosomal structure membrane
Q6BH63
MSDDTEWSEDILNRLNVRDQYEKKDSRYFKAFSQLSQEARTNDQASNNDKSIEYNKLLKENNQLKKDNEILTTSLNQTTISLEKSDLKINQLLKSQDQLERHNTSLNNKIKHLNLEIIEKNKSVEILNDELLLNEIQTNVLNDKITRLSDENKKLVERWIEKAKSDAEKLNDANEFLESVNRK
Function: Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 21537 Sequence Length: 183 Subcellular Location: Preautophagosomal structure membrane
Q5BH90
MAHWREEYAAALAARDRREKANVAIYNAYSQLADRTASSMIAVSDLQSDAQRSALSTPVADPRQQQPSPASGPSPQDIILAIRADLAEAQRSRSELEEQLARVTTELEKLRRRNIQNGKRISSMESEITHLQLRLKDRDEELREKAKLLEGFQDEIATFELQLNMAEERSNRLQKENQELIDRWMARMGKEADAMNDAYQFS
Function: Stabilizes the atg5-atg12 conjugate which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 23118 Sequence Length: 202 Subcellular Location: Preautophagosomal structure membrane
I1RFS8
MPNWRDQYLSGIKDAELNNPVNMELVQTCSQMADRISALEAEKNGLETLVTTNGKTTARPTEPSTNDPAVAQLKQDLAEALRSKGVAEKRLRSSEEELLQLRSKHKTNTRSIRDLTADKNSLTTRLKDREYELREKRKFIEQVQDEMIALNLQMSMAEKERDKVKKENKELVDRWMKRMAQEAEAMNLANEPIFKKGR
Function: Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) (By similarity). Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence . Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant . Location Topology: Peripheral membrane protein Sequence Mass (Da): 22848 Sequence Length: 198 Subcellular Location: Preautophagosomal structure membrane
W0T661
MEYELLESIRARDLVDKRFSQLFEEVPLVPKLEKAGEGDTNVKESSIKNLKDYLKLRDEEVYKLKDILKLKNRDTERLNDELLSANIESNLLQERLEKLQQEYDRLIERWLLKAQKEADTMNSHFK
Function: Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) . Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 15068 Sequence Length: 126 Subcellular Location: Preautophagosomal structure membrane
Q520U5
MSSLPDWRDEYLASIKEAEKNSPVNRDLVEACSQLQDRVAALEAERDALKASGASAGQSASDPASQSGDAAQSAVVARLRLDLAEALGTQERLQSRLGLAESELERLRAKTAEDAKTIRTLNTQCVSLSTKVKDRNEELQGKSKLVENVQDELIALTLQLNVMEQQKAKIQAENDQLVERWMKRMGQEAEAMNLANEPKFAKRG
Function: Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 22465 Sequence Length: 204 Subcellular Location: Preautophagosomal structure membrane
A7KAK0
MSWKNDLLAKLAQRDKSMETQKDVFLSFQFLSTRIASLERQLDTVQRDDSKKTVLDLLGEIDQLKQKLDLAEDSLKHETAKNKELVKELSTVKNNLNILTDGYKKLQERHLRLQEESKIKFQNLESLNDDILSLNIENNLLNDRMAKLKQENESLIERWMKRVKQEAEVLNDANEALSRSEKSLKPEG
Function: Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 21924 Sequence Length: 188 Subcellular Location: Preautophagosomal structure membrane