ids stringlengths 6 10 | seqs stringlengths 11 1.02k | texts stringlengths 108 11.1k |
|---|---|---|
P47818 | MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKLLG | Function: Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34250
Sequence Length: 322
Subcellular Location: Golgi apparatus membrane
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D4B5N6 | MLGGRHSHWSPQDLEEQAFSPYGTFPPSPTESTETSSSISSTRPRVNPRIVSDAILGLSDGLTVPFALSAGLSALGNSRVVVVGGLAELVAGAISMGLGGYVGSRSEVESYEATVRETKHLVKASPMETMNIIHQVFAPYNLPEEPVARMSHILYNSPEKLLDFLLTFYHKESKPGCHQAWISAITLALGYFIGGFIPLIPYFMVDQVLVALYYSIGIMIFTLLVFGYVKTCVVRGWTGKENIVAGIKGGLQMVVVGGLAAGASIALARAINPTGGALF | Function: Vacuolar iron transporter involved in the transfer of iron from the cytosol to the vacuole for intracellular iron storage . Plays an essential role in iron detoxification during high iron conditions .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 29779
Sequence Length: 279
Subcellular Location: Vacuole membrane
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Q3IZ91 | MALDVQSDIVAYDAPKKDLYEIGEMPPLGHVPKEMYAWAIRRERHGEPDQAMQIEVVETPSIDSHEVLVLVMAAGVNYNGIWAGLGVPVSPFDGHKQPYHIAGSDASGIVWAVGDKVKRWKVGDEVVIHCNQDDGDDEECNGGDPMFSPTQRIWGYETPDGSFAQFTRVQAQQLMKRPKHLTWEEAACYTLTLATAYRMLFGHKPHDLKPGQNVLVWGASGGLGSYAIQLINTAGANAIGVISEEDKRDFVMGLGAKGVINRKDFKCWGQLPKVNSPEYNEWLKEARKFGKAIWDITGKGINVDMVFEHPGEATFPVSSLVVKKGGMVVICAGTTGFNCTFDVRYMWMHQKRLQGSHFANLKQASAANQLMIERRLDPCMSEVFPWAEIPAAHTKMYRNQHKPGNMAVLVQAPRTGLRTFADVLEAGRKA | Cofactor: Despite some sequence similarity to zinc-containing alcohol dehydrogenases, this enzyme does not bind any metals.
Function: Catalyzes the NADPH-dependent reductive carboxylation of crotonyl-CoA ((2E)-butenoyl-CoA) to (2S)-ethylmalonyl-CoA, in the presence of CO2 . This is a key reaction in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source . Is also able to accept acryloyl-CoA as an alternative substrate, yielding (2S)-methylmalonyl-CoA . To a lesser extent, when CO2 is absent, the enzyme also catalyzes the reduction of crotonyl-CoA to butanoyl-CoA .
Catalytic Activity: (2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH
Sequence Mass (Da): 47684
Sequence Length: 430
EC: 1.3.1.85
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P30551 | MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP | Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 49657
Sequence Length: 444
Subcellular Location: Cell membrane
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P70031 | MESLRSLSNISALHELLCRYSNLSGTLTWNLSSTNGTHNLTTANWPPWNLNCTPILDRKKPSPSDLNLWVRIVMYSVIFLLSVFGNTLIIIVLVMNKRLRTITNSFLLSLALSDLMVAVLCMPFTLIPNLMENFIFGEVICRAAAYFMGLSVSVSTFNLVAISIERYSAICNPLKSRVWQTRSHAYRVIAATWVLSSIIMIPYLVYNKTVTFPMKDRRVGHQCRLVWPSKQVQQAWYVLLLTILFFIPGVVMIVAYGLISRELYRGIQFEMDLNKEAKAHKNGVSTPTTIPSGDEGDGCYIQVTKRRNTMEMSTLTPSVCTKMDRARINNSEAKLMAKKRVIRMLIVIVAMFFICWMPIFVANTWKAFDELSAFNTLTGAPISFIHLLSYTSACVNPLIYCFMNKRFRKAFLGTFSSCIKPCRNFRDTDEDIAATGASLSKFSYTTVSSLGPA | Function: Receptor for cholecystokinin. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Has high affinity for CCK-8 and low affinities for gastrin-17-I, CCK-4, and unsulfated CCK-8.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51157
Sequence Length: 453
Subcellular Location: Cell membrane
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P0DOA0 | MRPKWCKTTVLASFPRGSACTARQLKHSANRIYLDARASVPARRAGILNEDRIELPDDAIGASAERRSTRDLRKPSRAGIQHERAVGLMSRQTDNTYPKPLVMPKRGPSAALRLLIVGILLMGAAFIYFLFRDQLGDGFALVLMGVLSMVGVFYLFGAATGLIQFSQRSDHQDLAHSFMDTQPEGTVISDPRGQIVYANQAYARMTGATDADGIRPLDQVLASEPAASDAIYRLTNAVRDGLSAQEEVRISGGLSRGANGSLAPVWYRIKARALEGGAEFKGPLVAWQVADISEERAEQERFFQELQEAINHLDHAPAGFFSANPAGRIIYLNATLAEWLGVDLTQFTPGSLTLNDIVAGSGMALIKAVKAEPGTSRNTVIDLDLIKRNGQSLAVRFYHRVQTARDGMPGTTRTIVLDRAEGDDSSVAQRSAEVRFTRFFNSAPMAIAAVDAEGHTLRTNARFLDIFSGVVDRDAIDRRVKLENVVHERDRETFNKALAAAFAGQASISPVDTVLPGNEERHIRFYMSPVTDLGGEAAEEAAVISAVETTEQKALENQMAQSQKMQAVGQLAGGIAHDFNNVLTAIIMSSDLLLTNHRASDPSFPDIMNIKQNANRAASLVRQLLAFSRRQTLRPEVLDLTDVLADLRMLLARLVGKDIELKIDHGRDLWPVKADLGQFEQVAVNLAVNARDAMPEGGQITLRTRNIPAADAAKLHYRDLPEADYVVFEVEDTGTGIPADVLEKIFEPFFTTKEVGKGTGLGLSMVYGIIKQTGGFIYCDSEVGKGTTFKIFLPRLIEEKRADDAPVAAKEKKVEKATDLSGSATVLLVEDEDAVRMGGVRALQSRGYTVHEAASGVEALEIMEELGGEVDIVVSDVVMPEMDGPTLLRELRKTHPDIKFIFVSGYAEDAFARNLPADAKFGFLPKPFSLKQLATTVKEMLEKQD | Function: Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CckA autophosphorylates in the presence of ATP on a conserved His residue and transfers a phosphoryl group to a conserved Asp residue on its C-terminal receiver domain. CckA-P transfers phosphoryl groups to the ChpT phosphotransferase.
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 103190
Sequence Length: 945
Subcellular Location: Cell inner membrane
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Q9TS44 | AVQKVDGEPRAHLGALLARYIQQARKAPSGRMSVIKNLQNLDPSHRISDRDYMGWMDF | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 6610
Sequence Length: 58
Subcellular Location: Secreted
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O93464 | MNAGICVCVLLAALSTSSCLSLPAVSEDGGQSDLGIVMEHTRHTRAAPSSGQLSLLSKAEDDEEPRSSLTELLARIISTKGTYRRSPSPKSKSMGNNHRIKDRDYLGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut (By similarity). Induces the secretion of gonadotropin and growth hormone from the pituitary. Suppresses food intake and decreases the expression of preprosomatostatin genes in the forebrain.
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 13439
Sequence Length: 123
Subcellular Location: Secreted
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Q9PU41 | MYGGICICVLLAALSVSSLGQQPAGSHDGSPVAAELQQSLTEPHRHSRAPSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 14091
Sequence Length: 130
Subcellular Location: Secreted
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P06307 | MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 12669
Sequence Length: 115
Subcellular Location: Secreted
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O57312 | MTAGLCVCVLLAVLCTSCLGHPISSQHLDEGQRSISTPSEALLEADTHSLGEPHLRQSRSAPQLKSLPVAEEDGDSRANLSELLARLISSRKGSVRRNSTAYSKGLSPNHRIADRDYLGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity).
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 14773
Sequence Length: 135
Subcellular Location: Secreted
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Q9PU29 | MYSGICICVFLAVLSASSFGQQTAGSHNGNPLAAELEQSLTEHHRHVRAPSSAGPLKPVPRLDGSIDQRANIGALLAKYLQQARKGPTGRISVMGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity).
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 14273
Sequence Length: 130
Subcellular Location: Secreted
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Q21QL9 | MKTVPTLSFSKLGCSRGGRQLFQNIDCVLESGHWLYVAGANGVGKTSLLRMVCGLAPIESGEIFWNGTPIHAQADAYRQDLCYLGHLNALQESMTVHENLAFTAALGGMAPDMAQTQSVLAHFGVAGRDRQLVRHLSQGQKRRVALSRLALSQARLWVLDEPFVAMDEAGVRMLADLIAAHLTQGGLAVLTSHQQVDIGAIPAQLLELRA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 22682
Sequence Length: 210
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q0VR80 | MSQPATHSDAEPATRLVLEQLSCERDDRLLFSGLSFTASAGEIWQITGANGAGKTTLLRILVGLHGFYEGERQWWQPQWQQQLLYLGHEPGVREELNPLENLRYACALSQQGGDPMAALAAVGLQGFEEVPAAHLSAGQKRRIALARLWLDRKAVWVLDEPYTAIDQDGVAALDQQIQQAAEAGTLVIYTSHHQVGDGVRRLHLAHGQAEVTEGGRV | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23794
Sequence Length: 217
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q5E3S7 | MLEIRNVTCIRDERVLFERLNFTISDGELIQIEGQNGAGKTTLLRIIAGLGYADEGDIFWKNESIKQNREEFHSDLLFLGHHTGVKRELTAFENLAFYQSMHDNYNEAAIWDALARVGLAGREDVAAGQLSAGQQRRVALARLWLSNHKLWILDEPLTAIDKQGVKVLEKLFMDHAKQGGIVLLTTHQDLFIDSNELKKIRLGE | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23140
Sequence Length: 204
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q0A808 | MGDTALHLVAAPALEATGLQVARGGRPLFRGLGFRLARGGLLCVRGANGSGKTTLLRTLAGLSRPHRGRILRAGRCIRQAANDHRGTLQYRGHRDGLRGALTVLENLQWQAALYHHRPDREAVRTALAGMGMARHLDTLASQLSQGQRRRVVLASLALFPRCRLWLLDEPQAALDVEGAERFHALLARHCQEGGAVVACSHQHLRIGGIPCDELWLSDPAPAGARSAGDRVTGTEA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 25418
Sequence Length: 236
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q5PBP5 | MLECSDVSCIRGDRLLFENLSFVAKGGSITLVVGNNGSGKTTLLRTIVGLIPAASGSVRLDGEDITISSKCILQITYVGHKSACTGNMTVQEILEFWAQCRGTGELIDAAACFFGLYPILDVRFKNLSSGWQKRVALSRLLVSNTRVWVVDEPFSNLDPDAVALVQNLILTRAERGGIVILADHKKNDLFTDAQIVQIPPTDCGTHST | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 22498
Sequence Length: 208
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q5P3L0 | MVKSTPMLYAADLACLKGDRLLFRGLSLHVAPGAMLRIAGPNGFGKTSLLRILCGLAHPEAGEIRWNGRPIAGDRESFHRTLLYLGHAPALNDLLTPLENLRFACAAAGDDVDEDACVDALVRIGLADQLDLPARVLSQGQRRRVGLARLFLGIRRSLWVLDEPFTALDAAAVADLATTLSDHCAAGGVVILTTHQDAPFAVPPTVLDLSEVAA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 22776
Sequence Length: 214
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q6G529 | MVLSGKDLTAYRNEDVLFQGLSFCLFPQQLMTITGPNGIGKSTLLRIIAGLFKAAEGHVSLKDQEQIYPVATACHYLGPQNAMKPFLSVIDNLQFWSAFYGQPLHSPHEVLADIGLSDLEHVPFNVLSTGQKRRIAIARLLLSYRPVWILDEPISGIDSYAQTLLTNIFQYHLNQGGMIIAATHSPLGIPENHKITLEKFLPPQEKIQ | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23164
Sequence Length: 208
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q7WIP8 | MQNAEAAPALLAAHGLVGRRGGRRPLDLNLRPGQLVHVRGANGSGKTSLLRTLAGLLRPRRGEVRWNGADIHADLPGYYLHMAYLGHDNGCSDALTARENLRYALHVAGAPRAEPELERALRDWGLAAGADAPAARLSQGQGRRLALARVMLSRKRLWLLDEPDAGLDAASLQRLHGMLDAHLAGGGAAVLASHRGGGAWAGCTQTLELDEYAHAEVVGADCLA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23709
Sequence Length: 224
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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P30963 | MQLSGRRVICVRGGREVFAGLDFEAVSGEAVAVVGRNGSGKTSLLRLIAGLLIPAGGTIALDGGDAELTLPEQCHYLGHRDALKPALSVAENLSFWADFLGGERLDAHESLATVGLDHATHLPAAFLSAGQRRRLSLARLLTVRRPIWLLDEPTTALDVAGQDMFGGLMRDHLARGGLIIAATHMALGIDSRELRIGGVA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 21132
Sequence Length: 200
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q8YEM5 | MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVKLTEGTQIVPVRAACHYLGHQNAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVEHLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKASEARFAELMREHMRQDGMIIAATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 22908
Sequence Length: 215
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q9A298 | MLRAVLIKDLAISRGERTLFSKLDLTLRAGEAATLVGRNGAGKTSLLRAVAGLLRPAAGSTAFEDANGPVEADTARAEHLHMLGHQDGLKSSRTAWEELRFQTLWTGGNEDSARAAAQRFDLRRLLDLEVRRLSAGQRRRLALARLAASPRSLWLLDEPMAPLDAGQRAAFGAVMAEHVAGGGMILASVHDPLPIPARSVEVGA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 21813
Sequence Length: 204
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q87MK8 | MLEVSNLTAIRDERVLFENLQFEIKPGELVQIEGRNGTGKTTLLRIITGLGDREEGMIKWKGEEVEKSRDVFHQDLLFLGHQTGVKRELTAFENLRFYQSIQNNSTSDEEIFTALTQVGLAGREDVPVAQLSAGQQRRVALARLWLSKQILWILDEPLTAIDKQGVKVLEALFAQHADNGGIVMLTTHQDMFADSPKLRKIKLGD | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23112
Sequence Length: 205
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q73HX8 | MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRHCGKDIYDDPKSYISSMVYIGHKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPVLNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDSATCELVLNLISIRSEQNGIVIITGHSSTEQLCDFTTIDIRNFNRLLV | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23014
Sequence Length: 207
Subcellular Location: Cell membrane
EC: 7.6.2.5
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Q9PAP0 | MLCQYLPPDDRPPSSAPPLLAAHALTYSRNATPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIDINTHHNTTAPERTRHIAYLSHLPGLKQDLSALENLHFLNALHGYHPQRTPSNALTLVGLTDHAQTLVRQLSAGQKKRLSLAQLWLSPAPLWLLDEPYANLDPEGITLLNHILTAHIHTQGGTLLTTPGARPTLPVPTRLLHLKKAP | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 24256
Sequence Length: 223
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q668T8 | MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDNNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFVQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23932
Sequence Length: 218
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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Q5NQX0 | MGRKRLSDFGNARLACHDVSCLRGDRLLFTHLSFEVKAGEAVLITGANGIGKSSLLRLLAGFLKPFSGHIEKWGRVAFADEALAMDRHLPLEKALAYWAALDGVLGAEKEAMAVMALDILADSPVRLLSTGQRKRAVLARLLASQAAIWLLDEPANGLDAASVRALIEMIEHHRQKGGIILAVSHQGLDMADYKTLSLENFVANSGQSSGFFDLLDESHFS | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 23936
Sequence Length: 221
Subcellular Location: Cell inner membrane
EC: 7.6.2.5
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P93280 | MRRLFLELYYKLIFSSTPITSFSLFLLYIVVTPLMLGFEKDFLCHFHLGLIWISLLFSFLSAPFFRNEKEDGTLELYYLSTYCLPKILLLQLVGHWVIQISCVFCGFPMLQLLYQFGRSGMDWLNILLGSLVLTLLCGIHSCLALGITSSSGWNSLQNLTTLPTLLPLTVFCTSIETEWFHVLLLIGYFFLFVSLFPILVSISLQD | Function: May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23637
Sequence Length: 206
Subcellular Location: Mitochondrion membrane
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P30964 | MTALSALIRRDIRIALRVGGGALIGVLFFLTVVVLMPFAVGPDLALLSRLGPAILWLGALLASLLTLDRLFMADHEDGSLDLITMSRTPLELACAAKALAHWLAAGLPLIVATPVLGLLLNLDMVATGAVALTLLAGTPALTFTGMIGAALAVTLHRGGLLMAVLVLPLSIPVLIFGVAASQAVIVGPMSFGAPFSILCALSLVSLVIGPFAAAASLRHGLD | Function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22668
Sequence Length: 222
Subcellular Location: Cell inner membrane
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P0ABM0 | MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ | Function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23619
Sequence Length: 220
Subcellular Location: Cell inner membrane
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Q9I3N3 | MNPVRKKRLIIVLAIVAGVGAAVGLALSALQQNINLFYTPTQIANGEAPTDTRIRAGGLVEKGSLQRSEDSLNVRFVVTDGAKEVTIAYHGILPDLFREGQGIVALGKLGGDGVLVADEVLAKHDENYMPPEVTKALKDSGQLKHYENGKAAGETSYNQEGK | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 17239
Sequence Length: 162
Subcellular Location: Cell inner membrane
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Q8GQ96 | MKPRNRRIALIVAGLSALGIATALVLNAFQSNLVFFFTPSQVSAGEAPLERTFRVGGMVERGSLKRQRGELAVQFVITDTVKAIPVTYSGILPDLFSEGKGVVVQGRLDSAGLFRAEEVLAKHDENYMPPEAQHALDEVQKKPASRKP | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 16103
Sequence Length: 148
Subcellular Location: Cell inner membrane
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P0C1F6 | MNPLRRKRLLIILAILAGVGIAVGLAMSALRENINLFYTPTQIANGEAPLDTRIRAGGMVEQGSLKRSGDSLDVTFVVTDFNKAVTITYRGILPDLFREGQGIVALGKLNADAVVVADEVLAKHDEKYMPPEVTKALKDSGQSRLARIRSLPRRAK | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 16967
Sequence Length: 156
Subcellular Location: Cell inner membrane
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P48745 | MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM | Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival . Acts by binding to integrins or membrane receptors such as NOTCH1 . Essential regulator of hematopoietic stem and progenitor cell function . Inhibits myogenic differentiation through the activation of Notch-signaling pathway . Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling . Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival . Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts . Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification . Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway . Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement .
PTM: May be palmitoylated on Cys-244, which is important for extracellular secretion.
Sequence Mass (Da): 39162
Sequence Length: 357
Subcellular Location: Secreted
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Q64299 | MSLFLRKRCLCLGFLLFHLLSQVSASLRCPSRCPPKCPSISPTCAPGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEGDNCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQLDVLLPGPDCPAPRKVAVPGECCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDKKGKKCLRTKKSLKAIHLQFENCTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYSNCPQNNEAFLQDLELKTSRGEI | Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator . Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (By similarity). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion . Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis . Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (By similarity).
PTM: May be palmitoylated on Cys-241, which is important for extracellular secretion.
Sequence Mass (Da): 38928
Sequence Length: 354
Subcellular Location: Secreted
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P78396 | METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ | Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Sequence Mass (Da): 52358
Sequence Length: 465
Subcellular Location: Nucleus
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Q0WKY2 | MSGYERKNTTANSITITKRKRNSISEQSENVYEKSNRKESITLKPHRSFTPGFSQRDCKPVRHSKSSLRRRRRTKEKISSSVEREWVFSANNFENLADKLVLVSYNLLGVDNASNHMDLYYNVPRKHLEWSRRKHLICKEISRYNASILCLQEVDRFDDLDVLLKNRGFRGVHKSRTGEASDGCAIFWKENLFELLDHQHIEFDKFGMRNNVAQLCVLEMNCEEDPKSKLRVRSSDPRRLVVGNIHVLFNPKRGDIKLGQVRLFLEKAYKLSQEWGNIPVAIAGDLNSTPQSAIYDFIASADLDTQLHDRRQISGQTEVEPKERSFRNHYAFSASASISGSLLNEWSQEELQLATGGQETTHVQHQLKLNSAYSGVPGTYRTRDQRGEPLATTYHSRFLGTVDYIWHTKELVPVRVLETLPADVLRRTGGLPSENWGSDHLAIACELGFVNDWQ | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 52152
Sequence Length: 454
Subcellular Location: Nucleus
EC: 3.1.13.4
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Q8VYU4 | MRRSRFVAQVFSDVTFADASTISAPIFTMSTRAPYRGARGRGRGRGGRSFSDRPYNDDAGRDQFVTGDSHFQSVHDANFRFRHGEPYRQHQPPLDQRQQPPFNQNYEFRPPPPSRGQWQQFRQPNQFPSNQNYAACPPPPFYQNQMSRPPPQQSFRQRPRSKPSDYREWEYAKTPPSPGSEKFVVLSYNILADYLANDHWRSLYFHIPRNMLSWGWRKSKLVFELSLWSADIMCLQEVDKFQDLEEEMKHRGYSAIWKMRTGNAVDGCAIFWRSNRFKLVHEESIQFNQLGLRDNVAQICVLETLLTSHTKENETPPPESSAGSHRVVICNIHVLFNPKRGDFKLGQVRTLLDKAHAVSKLWDDAPIVLCGDFNCTPKSPLYNFISDRKLDLSGLARDKVSGQVSAEFRPPRPENYTTRYQSANKSPQGQVQPPNLITNAHMENNSNIDVGTAPSEKTSELPCGDTILAGHEATSSSDQVLPCENMASDCQFGIENRKPDDSGNLSTAEDLSSLTISDTEPQHASSAREDLNTDRSVSSGLSETEQTPEEICSSDQDISSSLSTKVDTFVAEMKLDGLKLDEPVVFAQDEESLGEDGETFLAKLHDNNENLSQKGELVSEVPLKWSSEALNSDKITYSPSSWTPMEIATATGDPERTTVEHALELKSTYSEVEGQANTRDENGEPVVTSYHRCFMGTVDYIWRSEGLQTVRVLAPIPKQAMQWTPGFPTPKWGSDHIALVSELAFCSSKTLPKS | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 84925
Sequence Length: 754
Subcellular Location: Nucleus
EC: 3.1.13.4
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Q4WQG5 | MYSQTHQGQHVMMNGGQAHQRFGMQIPKFQSQSHHPHHTQQPHHHTHHNQASHNINHQHNFSSGALASATPHFTPSHIQNGAHTNVDEDIDESMNEHWQQQLQLAAESRQASSPHYHARSVAQQAKGIQIAPSQPETQEQVPDGQNGVVKAKASSRQGWHALDFGGQGLRALSTSLFNYIFLEKLYLNHNKLKALPPAIGQLRKLNHLDLSGNDLTELPEEIGMLTNLKKLYLFDNNIRTLPYEMGYLYRLETLGVEGNPLNDVLKSHIMKEGTKALIKYLKEEMPAFFFSCTTPLTLMAVHLPPPDRDWIVLDETASSSNHRTDKVTVLSYNTLCDSSATQSHYGYAPARVLSWEFRRELILNELRSHDSDIICLQEIDQGSYNEYFREQLAYNDYKGVYWPRGRAMGMQEEDAKCVDGCATFFKGSKFILLDKQLINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVVFLENRQTGARFIVVNAHLYWDPAFKDVKLIQTAILMEELTKLSETYAKWPPCTDKAAFRFSKEEGQSETPPLEEPAPSMQYASGDQIPLLMCGDLNSSPGSAAYNLIAHGRLDEEHPDLEKRLYGNLSKVGMTHPFKLKSAYGAIGELPFTNYTPDFKDILDYIWYSSNSLHVSALLGEVDKDYLQRVPGFPNYHFPSDHIALLAEFTVKGKKGKVVEADFGPQRN | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 78849
Sequence Length: 696
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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Q5A761 | MNITNKFQHTPIQGQPQSNLQAQQILLSQLHQGQAQQQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESLNQNIYQNNYQRAQPSLQQQFFPQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPSSQQFYSQQQASVLQQQQQQQIQLQSAHQQQSSLLNMNSINVDNPNSVYWQHQQQLCQISRGSNVPHYYARQYASNSRKAKNPYSEVKSVGLVEATRSMVASLEDEEEKKKKPINYQGTPTTSAALLHNKKSTQDIFEDDSMEEQRMRLKTQGKQLWCQLDLSGQGLVNISSKLFHYDFLESLYLSNNKLNSIPSSISKLRNLRTLDLSHNRINELPEELGLCFNLRYLFLFDNNIKTLPYSFGNMIELLFIGIEGNPLEPSIANLIAEKGTKELIATLRDQTTVKRTPKPRCWLTLEDDGEVVDSDEVYKVEPESSDNFTVLSYNTLCQHYATPKMYKFTPSWALQWDYRKNLLEKEVLNYNTDIVCMQEVETKTFQEFWLPVMTANGYKGYFFSKTRSKTMSETDSKKVDGCATFFKNDKFSLIHKQNFEYNSVCMGSDKYKKTKDLFNRFMNKDNIALISYLQHKESGEKIAVVNTHLHWDPAFNDVKALQVGILLEELQGIIKKYRHTNSNEDIKNSSIVVCGDFNSVKDSAVYQLFSTGASKGHEDMNGRDYGKFTEDGFHHPFKLKSAYEAVGELPFTNLTPAFTDNIDYIWYSTPTLQVKGLLGGVDEEYTSHSIGFPDANFPSDHVPILAKFQLKKGKKNHSV | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 90325
Sequence Length: 787
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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P0CP22 | MFYPHHQSQQSTTTNPSKHHDSQDVRLPGTSSWSRHPSHPSFTPSLPMPSPSGYPPLGSGYPPGGHHHPNVNVHSGIHGPHPSFGSGMGGNGGMGHGQGFGMGMFQNGVQTSPPRGEPVPMTSHWQTQMMRAEASRSASSPHHRARAAAISSRATNKPSAVPIVDPNNRPSSSYGTNGLHRKNASSVFNGEPTGTPPLSDPSLTPAQNPAEPATPAPVAGQTESKDEEKPNEPWTGLDLGGIRLKRLSTALFSFTHVTSLYINHNALTSIPSAISSLRQLTLLDATGNELSTIPSEIGVLSKLKDLLLFDNNLTTLPFELGTLYQLDCLGIDGNPMNADYRKKLVEDGTRGLITYLRDHAPPPPPPPERQWIDLETDVDTPTSGKQESFSVLTYNILCASFAPATTYSYTPSWALDWDYRKRLLLEEIVTASADVVCLQEIDCKQYADYFYPMLKKEGYEGQHYPRSRAKTMSVDEQKLVDGCATFWKEEKFRLVETQVIEFNQLALQKTDMRTEDMFNRVMSRDNIAVVAALEFRASGGRLLVANSHIYWDHRYRDVKLVQIGMLMEELEKIVEQFSRYPVKLDTDPEYNNGKPPKYERSEKGRDIPLIMCVDLNSFSGSAVYDYLSSGSIPGDHEDFMSHLYGRYTASGLKHHLGLRSACAGIGEMRMTNFTPTFAAAIDYVFYTPRTMKVTSVLGDVDKAYLDKTVGFPNAHFPSDHIPVFTQFRIKGHLDPLPLNGDPYH | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 82377
Sequence Length: 744
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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Q5B778 | MYSQTHQQQHVIMNGGQAHQRFGMQMKFQTQNHHPHPAQQPHHHAHHNQPPQHVGHQHNFSSGALASATPHFTPSHIQNGTHTNIDEELDESMNEHWQQQLQLAAESRQASSPHYYARAVAQQTKGIQIAPSQPEAQENGVNQKNGITKTKPASRQGWHALDFGGQGLRALAPSLFKYAFLEKLYLSHNKLKVLPPQIGQLRKLTHLDLSANDLTELPEEIGMLTNLRHLLLFDNNIRTLPYEMGYLYRLEILGIEGNPLEDVLKSLIMKEGTKALIRYLKEEMPVHVPPPARDWLVLDETAATSPDKVSVLSYNTLCDSSATQSHYGYAPSRVLSWEFRRETILNELRAHDPDIICLQEIDQGSYNEFFREQLAYSDYKGVFWPRGRAMGMQEEDAKGVDGCATFFKGSKFILLDKQVINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVIVFLENRQTGSRFIIVNAHLYWDPAFKDVKLIQTAILMEEITKHSEKYAKWPPCTDKAAFRFREAQGEQTMPEPAPSAEYASGDQIPLFMCGDFNSSPGSAAYNLIANGGLIEEHPDLEKRMYGNLSKVGMTHPFKLKSAYGAIGELSFTNYTPDFKDILDYIWYSSNTVHVSGLLGEVDKDYLQRVPGFPNYHFPSDHIALLAEFSVKGKKGKVVEADFGPQRN | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 76463
Sequence Length: 675
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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Q8SU52 | MAEECLVSRKKFGGKAMEVRSEMWTGLDLCSQGIKNISKSLFDMRFIRTLNLANNEIEVIPREICNLRHLEVLNLSKNKIRSIPPEIGKIVSLRELNLSDNLISNIPMEMGTLYNLEVFEIANNPLIVPFNTLIRDKKLLQFCREHNTGYPPPNDRLWIECTGKNVFYGDTVSVGTFNILSNIYATRMTYAPSWVINSEFRREGVLQEIVLYNVDILCLQEIELYSFFDFYKEQLEMRCNYDSIIYPRGRVKSVPDKKNVDGCAIFWRRSKFRLIAQFPIDFHQKVIQDTRFNTNQELLDRYGKKDNIAIGALLERPNGQQVLVMNTHIFWDPDYPDIKLLQVLLLVEEIKRVSSRHPNACLLLQGDFNSLRSSSVYKSITTPVIDFADFGDTMQHLSNQQFGDGLGLNDAYSNQDLGFTNFTPGFKGVIDYIFYGGGISLASVLSPVEDEYTENVAGLPNMHFPSDHIFLGAKFAFPNKNISQNAFGRNSRQ | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 56489
Sequence Length: 493
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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B7XK66 | MEEKIKKKDYNKDIDNCDDELEGLDMSFQGIKVIGKEITLLVSLKQLILNNNDIETIPEDISNLIRLEVLDFSYNKIEKIPTELGRLINLKELYLNNNMIVEVPMELGTLYKLENFSILNNPLVHPYGIMSKDKSLLRFCRENNTNYKQPNDRVWIDTVLKIDQSLETYSFGTFNILCSLYASNLTYAPSWVINLECRKDILMQTFIAYNLDILCLQEVDINVFNTFYKEQLAQKLDYDGVILPKKSFDKVTDQPKKFHGIVTFWKKNKFKLIEQVSIDFFQKIINDKRFKYLSDIHTRIFQKTNVGLITIFETCNTNIIIIVANVHLYWNPEFNDIKILQTIIYLEEIEFLKEKYKHAHIVLQGDFNSLQNSHVYQYIINRKLPTNIFDPWDYGSLNNGVTHSLTLRNAYDGHDITFTNFTPSFKAVIDYIFYSKYLNLISIISPIEDEYTKTTIGLPNIHFPSDHILIGAKFQFKSSKK | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 56348
Sequence Length: 481
Subcellular Location: Cytoplasm
EC: 3.1.13.4
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P51679 | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL | Function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
PTM: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 41403
Sequence Length: 360
Subcellular Location: Cell membrane
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Q7VA54 | MKYLRKIINWLSSLKVAIVLLILIALGSALGTALPQGEKAESYLKNYEVTRFLGVINGDLLLQLQLDHVYSSFWFLFLLTWLSFSLIICSWKRQWPSLKKAIDWIDYKEPKQIQKLAISQSFRIQKNDNGINPLANYLENNGWQVKIKSSRLAARKGLIGRVGPPLVHFGLILLIIGATYGVLKGQRLEKFLAPERSLNLLSPNGISKVSVKLTDFKIDRDPTGKPEQFRSKLELHNNNINKSIYEEISVNHPLRFQGITLYQADWSLAAITIQINNSPKIQFPLNKIDELGDQVWGIVLPQMPDSDLKPLLLTLSSEQGPVRFFSEEGNPAGIGRPNGNPILIGTSKISIIDVIPSSGILLKYDPGVPIVYLGFAISLIGSVFSIISTKQLWIIQEEESRLMHIGGLSNRNLSGFANQFNSIIKAAYD | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48044
Sequence Length: 429
Subcellular Location: Cellular thylakoid membrane
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A6MVS2 | MLIKINQYFRKSISVLGNLKLAIILLLMLALFSAFGTVIEQNQNVAFYENSYPNSAPLFGFLSANAILFLGLNNIYQTWWFTTLILLLAVSLFSCTLARQIPSLKMARLWQFYTKDQSLKKIGLSFNLQKTSLSKLAFTLKTDDYNVIQKGRFLYAYKGLPGKIGPIIVHASLIIILFGALLGNLSGFVSQELVPLGGVFHIQNIINSGTLSYVPQNFEGYVKDFKIAYNDEGSIDQFYSDLSILNSTGEEVRSKTIYVNEPLRYEGIVFYQTDWSITNLAINVDQQTNIQLPLKSINVKGEGKFWIASLPIANVEKATNDNILLVLEDLTGKILLYSSNQQLLAIVNVGENISLNGHSVKVTDIISSTGLQIKSDPGIPFVYIGFFLLMLSITLSYFSYSQVWAIKDNKTLYVSGRTNRAIYSFEQQITKMMNKLNSTYA | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 49475
Sequence Length: 441
Subcellular Location: Plastid
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Q31RG5 | MTSDPLASPSFADRWRRGQQLFWTWLADLRLAILLLLAIAIASATGTVIEQGQSLAFYQENYPTDPALFGFLSWRWILSLGLDHVYRAGWFLGLLILFGASLTACTFRRQWPALRAAQRWQFYQEPRQFTKLALSASLPQGKLDSLEPLLLQRRYRLFRADDVLYARRGLAGRVGPILVHAGMLVVLGGAIWGSLGGFYAQEMIPSGETFQVRNIVDAGPWSGSRIPQDWAVKVNRFWIDYAPDGRIDQFYSDLSVVDREGQEQDRQTIHVNQPLRYGGLTFYQADWAIAAAQVRLNNSPVLQLPMAQLPAAGRIWGTFVPTKPDLSSGVSLIAKDLQGTAVIYGSNGEPLGTLRKGMAIEVEGIRLSLVDLVGSTGLQIKSDPGIPWVYAGFLFVMVGVVCSYVSHAQVWALEQDGQLYIGGRSNRALVAFEQEMLAVLAQLDAQSNHSAETAIA | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50461
Sequence Length: 456
Subcellular Location: Cellular thylakoid membrane
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P38273 | MRLHYITVFDPSRSTNENDTFKQLLLFHYFGTTDSIPSLNEKLSIIGVIQGIWSLTSSCVNKDGEDLEKIIELNNDIIFCIKVESRFFISLAISNISDDQSAIPLQYLSAYLWLSYRFFKLLNGSFSGFNKDFRKLTDLLNEFVIPFWNDIYLNLETVTNRSFTVMWPGFYKRANFQHSSYNPGEKNNVEESWDAIILQNILLDKKSYLGLKDILVYHLPKRTKAANRESMGTKTYGLVRNFTSDLNTLPDISNWLYHLHCTYGEISSHILTGNVHFKEELQVEEEQERSRDTNGRDEEESQEQQRREHQETTQNNTSELSLSERVIHNVTLPISFAYDAIHEVSTTTGVSGSLSMIMDYVPKPHWPFISSSNKSADKNNYSNSNDNANSNAPLMAQSEAVGGTIGNSRFGFLISPLNSDLLPSSYQALKLNLNFENSKDKEDFYNCLFWYFDDFLIVIVCDPDFNKICERDYLKDLSFQLCQSMECLNNEILNSQNCDNVESFAYVIRDNVTKEIDSSVPFGSPKFTSDESISTLQLAINGIDQFINDNSNSLSLANWNPITIMGGSNAISKKNTTEGFGNGVNDKTQKFKRKYLNFLNLMSAEKLWDLQVDVLQFLTSLQNSKRDPDYFQEERLLKLNNGVLCYIKENNSNLIIIIKNWFQNNGTSKAAKQRNRFSSDSSKGSSLFQSLGRDVTDWWESREI | Function: In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking . The CCZ1-MON1 complex acts as a guanine nucleotide-exchange factor (GEF) for Rab-type GTPase YPT7, promoting nucleotide exchange on YPT7 and triggering endosomal maturation by activating YPT7 on late endosomes .
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 80732
Sequence Length: 704
Subcellular Location: Endosome
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Q3C2E2 | MTTPRNSMSGTLPVDPMKSPTAMYPVQKIIPKRMPSVVGPTQNFFMRESKTLGAVQIMNGLFHIALGSLLMIHTDVCAPICITMWYPLWGGIMFIISGSLLAAADKNPRKSLVKGKMIMNSLSLFAAISGIIFLIMDIFNITISHFFKMENLNLIKAPMPYVDIHNCDPANPSEKNSLSIQYCGSIRSVFLGVFAVMLIFAFFQKLVTAGIVENEWKKLCSKPKSDVVVLLAAEEKKEQPIETTEEMVELTEIASQPKKEEDIEIIPVQEEEGELEINFAEPPQEQESSPIENDSIP | Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
PTM: Phosphorylated. Might be functionally regulated by protein kinase(s) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 33056
Sequence Length: 297
Subcellular Location: Cell membrane
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P11836 | MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP | Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR .
PTM: Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 33077
Sequence Length: 297
Subcellular Location: Cell membrane
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Q15762 | MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV | Function: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell . Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding .
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 38614
Sequence Length: 336
Subcellular Location: Cell membrane
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Q8K4F0 | MAYVTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSFYNASEADIGIYSCLFHAFPNGPWEKKIKVVWSDSFEIAAPSDSYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRQTRSNCSQGSMKSILIIPNAMAADSGLYRCRSEAITGKNKSFVIRLIITDGGTNKHFILPIVGGLVSLLLVILIIIIFILYNRKRRRQVRIPLKEPRDKQSKVATNCRSPTSPIQSTDDEKEDIYVNYPTFSRRPKPRL | Function: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
PTM: Phosphorylated.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 38063
Sequence Length: 333
Subcellular Location: Cell membrane
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P20273 | MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
PTM: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 95348
Sequence Length: 847
Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Subcellular Location: Cell membrane
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P35329 | MRVHYLWLLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSKVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDTHNTGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
PTM: Phosphorylated on tyrosine residues by LYN.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 97181
Sequence Length: 868
Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Subcellular Location: Cell membrane
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Q9N1E6 | MHLLGPWLLLLVLEYLAFSDSSKWAFEHPETLYAWEGACVWIPCTYRALDRDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHVNDSGQLGLRMESKTAKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGESVTMTCEVSSSNPEYTTISWLKDGTSLKKQNTLMLNLHEVTKDQSGKYCCQVSNDVGPGRSAEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPTPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWGNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESRLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGHSPLSTLTVYYSPETIGRRVAVGFGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGYYNPMMEDGISYTTLRFPETNIPRTGDAETSEMQSPPPDCDDTVTYSVLHKRQMGDYENVIPDFSEDEGIHYSELIQFGVGERPQAQENVDYVILKH | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
PTM: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 95274
Sequence Length: 847
Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Subcellular Location: Cell membrane
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Q9N1E3 | MHLLGPWLLLLEYLAFSDSSKWAFEHPETLYAWEGACVWIPCTYRALDGALESFILFHNPEYNKNTSKFDGTRLYESTKDGEVPSEQKRVQFLGDKSKNCTLSIHPVHVNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWFLEGVPVGQAAVNSTSLATKSVFTRSELKFSPQWSHHGKIVTCQLHGADGKFLSNDTVQLNVKHTPKLKIEVNPSDAIVREGDSVTMTCEVSSSNPKYTTVSWLKDGTPLKKQNALMLTLQEVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPE | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 37257
Sequence Length: 330
Subcellular Location: Cell membrane
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Q9BZW8 | MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFESLLPDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRRNHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLIQPSRKSGSRKRNHSPSFNSTIYEVIGKSQPKAQNPARLSRKELENFDVYS | Function: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor . Activating function implicates association with SH2D1A and FYN . Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 . Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis . Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 . At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells . Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity).
PTM: N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 41616
Sequence Length: 370
Domain: The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Subcellular Location: Membrane
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Q07763 | MLGQAVLFTTFLLLRAHQGQDCPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAKLQDSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQLFLSCLVTKDDNVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHGCQSVPSNFRFLPFGVIIVILVTLFLGAIICFCVWTKKRKQLQFSPKEPLTIYEYVKDSRASRDQQGCSRASGSPSAVQEDGRGQRELDRRVSEVLEQLPQQTFPGDRGTMYSMIQCKPSDSTSQEKCTVYSVVQPSRKSGSKKRNQNSSLSCTVYEEVGNPWLKAHNPARLSRRELENFDVYS | Function: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor . Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis . Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells . Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly . Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells . Inhibits inflammatory responses in dendritic cells (DCs) .
PTM: N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding (By similarity).
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 44836
Sequence Length: 397
Domain: The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Subcellular Location: Membrane
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P01731 | MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICYHRSRKRVCKCPRPLVRQEGKPRPSEKIV | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
PTM: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 27456
Sequence Length: 247
Subcellular Location: Cell membrane
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P07725 | MASRVICFLSLNLLLLDVITRLQVSGQLQLSPKKVDAEIGQEVKLTCEVLRDTSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLNDILDPNLFSARKENNKYILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGTPRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRRVCKCPRPLVKPRPSEKFV | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
PTM: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 26196
Sequence Length: 236
Subcellular Location: Cell membrane
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P79336 | MQPGLWLLLATQLAALRGSSVLQQAPGSVMVQTNGMVIMSCEAKTSPTSTRIYWLRHRQAPSPDSHYECLAYWDPIKGIVYGQEVEPEKLTVFPDATRSILNLTSVKPADSGIYFCMTVGSPELTFGKGTRLSVVDVLPTNSQPTKKPTPRKKMCRPPSPVTQKGPSCGLLTLGLLVAGVLVLLVSLGVAIHLYRLKRRARLRLLKQFYK | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
PTM: Phosphorylated as a consequence of T-cell activation.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 23105
Sequence Length: 210
Subcellular Location: Cell membrane
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P10966 | MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
PTM: Phosphorylated as a consequence of T-cell activation.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 23722
Sequence Length: 210
Subcellular Location: Cell membrane
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P14209 | MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK | Function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
PTM: Extensively O-glycosylated.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 18848
Sequence Length: 185
Subcellular Location: Membrane
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Q8VCN6 | MARAAMEAAATVVLALALLGAAARGAASDDFNLGDALEDPNMKPTPKAPTPKKPSGGFDLEDALPGGGGGGAGEKPGNRPQPDPKPPRPHGDSGGISDSDLADAAGQGGGGAGRRGSGDEGGHGGAGGAEPEGTPQGLVPGVVAAVVAAVAGAVSSFVAYQRRRLCFREGGSAPV | Function: Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 16783
Sequence Length: 175
Subcellular Location: Membrane
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P21926 | MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion . Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles . Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation . Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis .
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids . Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 25416
Sequence Length: 228
Subcellular Location: Cell membrane
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P40240 | MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRSKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion . Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion . In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration . In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption . Acts as a receptor for PSG17 . Involved in platelet activation and aggregation . Regulates paranodal junction formation . Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung .
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 25258
Sequence Length: 226
Subcellular Location: Cell membrane
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Q8WMQ3 | MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNNSSFYTGVYILIGAGALMMVVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDQVIKEVQDFYRDTYNKLKGKDDPQRETLKAIHYALDCCGLMGEVEQLLADICPQRDVLSSLPMKPCPEAIKEVFQNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 25201
Sequence Length: 226
Subcellular Location: Cell membrane
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P40241 | MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRNKDEPQRETLKAIHMALNCCGIAGGVEQFISDICPKKQVLESFQVKSCPDAIDEVFHSKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 25215
Sequence Length: 226
Subcellular Location: Cell membrane
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O65896 | MDKPSFVIQSKEAESAAKQLGVSVIQLLPSLVKPAQSYARTPISKFNVAVVGLGSSGRIFLGVNVEFPNLPLHHSIHAEQFLVTNLTLNGERHLNFFAVSAAPCGHCRQFLQEIRDAPEIKILITDPNNSADSDSAADSDGFLRLGSFLPHRFGPDDLLGKDHPLLLESHDNHLKISDLDSICNGNTDSSADLKQTALAAANRSYAPYSLCPSGVSLVDCDGKVYRGWYMESAAYNPSMGPVQAALVDYVANGGGGGYERIVGAVLVEKEDAVVRQEHTARLLLETISPKCEFKVFHCYEA | Cofactor: Binds 1 zinc ion per subunit.
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Functions as a conventional cytidine deaminase. Has no affinity for RNA and is not involved in RNA-editing by C-to-U deamination.
Catalytic Activity: cytidine + H(+) + H2O = NH4(+) + uridine
Sequence Mass (Da): 32582
Sequence Length: 301
EC: 3.5.4.5
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G0SDN0 | MAPRRRRGAGQDGSDDGRSDSDAPKNRPPNTAFRQQRMRAWQCVLTPKLIVTVFSILAAIYLGFGAWLTYLAHTVRDLKIDYTDCLTSAPKDDFETIPQNHITAHFSAKDSTFDPYKAQWKTTEREVQVANYTDNRQFCIVRFNIPEDLQPTISFFYYLENFYQNHRRYVNSFNAKQLLGDAVDGKTINDSTCDPITHDPKGTGKIVYPCGLVANSIFNDTFSSPLALAVRNSSDSSRPYNMTTKGIAWPGLKDLYGKTSYSLDQIVPPPNWERRYKYGYQENNPPPDLKTDELFQNWMMLAAAPNFYKLYQKNDTHPMLAGQYEIEIESNFDVTVYKGRKAFVITTLSTMGSRNIWPGIIFLIVGGICLVLDIYFILSFFIWRPRKLGDPSYLSWNQPSAPGGHSS | Function: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and phosphatidylserine from the lumen to the cytosolic leaflet of membranes and ensures the maintenance of asymmetric distribution of phospholipids.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 46402
Sequence Length: 407
Subcellular Location: Cell membrane
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S7WII9 | MGENSTTGLRGQADVSQFSDAAVEPTLSSPPTGQRQQSLPLFGEETCSISSAPSVGGGGGWPFQRQGSSRLTSRGTSLSSCSDAGSGLGALRQREDSFPEYHGVGLPLGGKYALDGTGLVLAPRVPFIFSHQLPSLTGLDEAGFSDTRKVPSTYQALAARFVHQVHQEAGNGMYPLWSAGVVLRLCLLGALFFVSVGAWLIFEDEQHVECKLNYAEKTLQEGSSRYLLKGISSAHCTREVNELKGEEISVYAEMGHFFQNDAQVLWSRNDRQLAGKIFTDPKDVRECEPLATAVVGNVTKVLHPCGALAWAVFTDKYQFLEGTPEGDNDQVPMKPIPLNQTQAVLLHSWPWQDMYKNPPAEDRAAVLDKVYFWMSPVDNDDGEDMYKTREEARAELLMDRLNYEEAGEMVENGHFIQWMQTAALGTFRKLYGSLEGPLKLPVSAHITVMYDVSSWKGKKAIVLVQKSRLGGRSLFIGIAYLSFGCLLTMLVFYMLWKKWQYRREGEEIRDLRWQTKTRGSKKTK | Function: In tachyzoites, required for the cellular trafficking of guanylate cyclase GC and UGO to the cell membrane . May play a role in the folding of the GC P-type ATPase-like domain to sense vacuolar changes in phosphatidic acid and pH levels which trigger parasite egress .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 58191
Sequence Length: 524
Subcellular Location: Membrane
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P25656 | MVSLFKRGKAPPLTKEGPTSKKPPNTAFRQQRLKAWQPILSPQSVLPLLIFVACIFTPIGIGLIVSATKVQDLTIDYSHCDTKASTTAFEDIPKKYIKYHFKSKVENKPQWRLTENENGEQSCELQFEIPNDIKKSIFIYYKITNFYQNHRRYVQSFDTKQILGEPIKKDDLDTSCSPIRSREDKIIYPCGLIANSMFNDTFSQVLSGIDDTEDYNLTNKHISWSIDRHRFKTTKYNASDIVPPPNWMKKYPDGYTDENLPDIHTWEEFQVWMRTAAFPKFYKLTLKNESASLPKGKYQMNIELNYPISLFGGTKSFVLTTNGAIGGRNMSLGVLYLIVAGLCALFGIIFLVKLIFQPRAMGDHTYLNFDDEENEDYEDVHAENTTLREIL | Function: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylserine and small amounts of ethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids . Required for the formation of transport vesicles from endosomes .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 44982
Sequence Length: 391
Subcellular Location: Golgi apparatus
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Q12018 | MSETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGESYAYLA | Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes.
PTM: Neddylated; enhancing the ubiquitin-ligase activity.
Sequence Mass (Da): 93944
Sequence Length: 815
Subcellular Location: Cytoplasm
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Q99459 | MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF | Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes . Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
PTM: Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Sequence Mass (Da): 92251
Sequence Length: 802
Subcellular Location: Nucleus
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Q8SWM6 | MSTKVELYMEIGTVITDLEYHTKYMLKKLLGRGAYAQCYLAEIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKLDNPNVVKMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSKKEHFLMKIYRNLMTNRTEEGVVDTDYVLFSIPVTKLRGVGYVLKSGVYGIYFSDHRNLMLKPNRKSVIYLNSTIESGKRVFYKEEHLVEKIPAEIAESYKGLQYFIRTFDNGFSFLDVEPCFIVKIRKIECGFLFVMADSTIVFDFVDGWRVVLSRCGERVSCYNGLGLASFNQEIRGRCIEILRGCLGCG | Function: Protein kinase required for the cell cycle where it is involved in mitotic exit. Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 54024
Sequence Length: 472
Subcellular Location: Cytoplasm
EC: 2.7.11.21
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P32562 | MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKRLDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDKLEEYHQNRPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD | Function: Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 81031
Sequence Length: 705
EC: 2.7.11.21
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O27463 | MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGKTGTGKTAVAKFAMKQLKEASKDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGWTKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGDGLLYTLTRTDNVSILSISNYVEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAAKEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVLEAILYLTKRKEEITSGRLYEVYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGKGRTNIIDLQCETSLLEDSLWGV | Function: Involved in regulation of DNA replication. May play an essential role in origin recognition. Binds to DNA, with a preference for origin-specific double-stranded sequences. Does not bind single-stranded DNA. Inhibits MCM helicase activity but does not affect its oligomeric state.
PTM: Autophosphorylated on a serine. Phosphorylation is stimulated by binding to MCM. Both single-stranded DNA and double-stranded DNA inhibit the phosphorylation reaction.
Sequence Mass (Da): 43875
Sequence Length: 382
Domain: The N-terminal AAA+ ATPase domain and the C-terminal winged-helix (WH) domain are both required for DNA binding.
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Q3YL95 | MKKKLFALLKYIIFFPMLCTVLGLLGIPIGLIVNFLRTGSFDFNLKDEIDVVLFTLKIGIPIGFILGLGLWGLSILDRK | Function: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against CdiA from the same strain, its cognate toxin protein . Growth inhibition is reversible upon induction of this protein, occurring about 2.5 hours after induction, and requires an energy source . Does not protect against non-cognate CdiA from E.coli strain 563 / UPEC, D.dadantii strain 3937 or Y.pestis strain CO92 .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 8856
Sequence Length: 79
Subcellular Location: Cell inner membrane
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Q74RU7 | MKNLLYVVLLMAVCILGLLIVGTIFYLFLEVFMYFYVNAPISLESFQFTRLLKMSIYGGGILGLGIGLLRIFKIKGF | Function: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the CDI activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E.coli strains 563, EC93 or D.dadantii strain 3937.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 8719
Sequence Length: 77
Subcellular Location: Membrane
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Q54HX8 | MGQDNINLNKVDGQPSSPPQEQQQQQQYPPQGYPQQQQYPPQQGYPPQQYPPQQGYPPQQYPPQQGYPQQQPPQQYPAPVGAPQQPYMATQQVVVQQVYVQPTFGVVPVDCICQHCQTRMSTKTSYKSGSMVWLVCVLLIIFGCWLGCCLIPFGIDSLKDVQHKCSHCKKVLYRFDRMSGK | Location Topology: Peripheral membrane protein
Sequence Mass (Da): 20589
Sequence Length: 181
Domain: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Subcellular Location: Late endosome membrane
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Q9H305 | MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPLPPADIGPPPYEPPGHPMPQPGFIPPHMSADGTYMPPGFYPPPGPHPPMGYYPPGPYTPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC | Function: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 21892
Sequence Length: 208
Domain: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Subcellular Location: Late endosome membrane
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Q00534 | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA | Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases .
PTM: Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 36938
Sequence Length: 326
Subcellular Location: Cytoplasm
EC: 2.7.11.22
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Q64261 | MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQSTSELNTA | Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases.
PTM: Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 37028
Sequence Length: 326
Subcellular Location: Cytoplasm
EC: 2.7.11.22
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G5EFV5 | MSRRYDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKLTDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYMALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQPQKRSRRLDDDGTRPVRRLNFD | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 38353
Sequence Length: 330
EC: 2.7.11.22
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P51953 | MALDVKSRAKLYEKLDFLGEGQFATVYKARDKTTNTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLLCFMETDLEVIIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLDQLTGIFEALGTPTEETWPGMSNLPDYVSFKLFPGTPLEHIFSAAGDDLLELLKGLFTFNPCTRTTASQALKMRYFSIRPGPTPGPQLPRPNSSTEALKEKENLLIGIKRKRDSIEQGTLKKKLVF | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of cdk1/cyclin-B during G2-M transition, and for activation of cdk2/cyclins during G1-S transition (but not complex formation). cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates the cyclin-associated kinases cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts (By similarity).
PTM: Phosphorylation of Ser-163 during mitosis inactivates the enzyme. Phosphorylation of Thr-169 is required for activity. Phosphorylated at Ser-163 and Thr-169 by CDK2 (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 38510
Sequence Length: 344
Subcellular Location: Nucleus
EC: 2.7.11.22
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P54685 | MDKYNIEALIGEGTYGVVSRATVKATGQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDHPATPFKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLLQQRQVLAQVQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV | Function: Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 40567
Sequence Length: 360
Subcellular Location: Nucleus
EC: 2.7.11.22
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P50613 | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts . Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
PTM: Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 39038
Sequence Length: 346
Subcellular Location: Nucleus
EC: 2.7.11.22
|
P20911 | MEGIAARGVDVRSRAKQYEKLDFLGEGQFATVYKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPGMSSLPDYVAFKSFPGTPLHLIFIAAGDDLLELLQGLFTFNPCARCTASQALRKRYFSNRPAPTPGNLLPRPNCSIEALKEQQNLNLGIKRKRTEGMDQKDIAKKLSF | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of cdk1/cyclin-B during G2-M transition, and for activation of cdk2/cyclins during G1-S transition (but not complex formation). cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates the cyclin-associated kinases cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in negative regulation of the meiotic maturation of Xenopus oocytes.
PTM: Phosphorylation of Ser-170 during mitosis inactivates the enzyme. Phosphorylation of Thr-176 is required for activity. Phosphorylated at Ser-170 and Thr-176 by CDK2 (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 39691
Sequence Length: 352
Subcellular Location: Nucleus
EC: 2.7.11.22
|
P0C661 | MIDENFKKKLAVSRERVEDLFYFENSKEIGRGTYGLVYKAVPKHSNGRFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKTKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGGPDMRGRVKIADLGFSRIFANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDTDWPDMKKMPDHQRLLNDARNEGTPIQTFPNSLQRYFDKWKINSQSSPYRLLVKLLTVDPLKRVSCEEAMNDIYFRKMERPPRETDDVFNRYPIPYAKKEQQITIPIDQFQQQQQQQQQQQQQQQQQQQQQQQQQMQQPQIGPPQMMGQPQMGQPQMGQPQMGQPQMGQPQMGQPQMVPSQMGQPPMGGPHPGVVAPDGHAHQMMQQQHQSQHHMQYQQMHDSMQGGMDDGGPQAKMMRMGNVPVGRYGPMGPPYGPQDFHAPQGPPMMQMMPQPGPSGYYQQRPGQPPGPGPQGYMNPQMGMTMGMRPQGVPQQAYMPGRGMPPPQGPNPQQQQQWQQYHR | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 70642
Sequence Length: 612
Subcellular Location: Nucleus
EC: 2.7.11.22
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P90866 | MTLMIDENFKKQLAQRRERVEDLFYFENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMNDIYFRKMERPPRETDDVFNKYPIPYAKKEQQMTVAPDQAQQQHQQQQVQMQQQPQMGQQQMMGQPQMVQPQMGQPPMGGAHPGVVAPDGHPHQMMQQQQHPQQHHMQYQGMHDPMQGGMDEGPQAKMMRMGNVPVGRYAPMPPPYGAPQDYHPQQGPPMVQMMQQPGPSGYYPQRPGQPTGAVPGPGPQGYMNPQMGMQMGMRAPGVPPQGYMPGRGMAPPQMGQQQPGPNQQQQQQWQQQYHR | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 67785
Sequence Length: 588
Subcellular Location: Nucleus
EC: 2.7.11.22
|
Q95YH0 | MNTHNQSSNQNGGGSGGGGGGGGSSTFSPIVLTSTYRLDVQEKYTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRITASEALDHPYFKELPLPLPNAFSKPIPYPPRLPINKKKREFDD | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). Involved in cell aggregation, but not growth. Required for starvation-induced expression of genes essential for early development of acaA and/or other genes.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 42771
Sequence Length: 380
Subcellular Location: Nucleus
EC: 2.7.11.22
|
Q9VT57 | MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQQQQMMFNQQQNFQRFN | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 53682
Sequence Length: 454
Subcellular Location: Nucleus
EC: 2.7.11.22
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P49336 | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 53284
Sequence Length: 464
Subcellular Location: Nucleus
EC: 2.7.11.22
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Q8R3L8 | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 53210
Sequence Length: 464
Subcellular Location: Nucleus
EC: 2.7.11.22
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Q66KH9 | MDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDRDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDFAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIKKMPEHSTLIKDFRRNTYTNCSLIKYMEKHKVKPDSKTFHLLQKLLTMDPIKRISSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDNSHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYQNPGPSTSQPQSSMGYTSTSQQPPQYSHQTHRY | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 47763
Sequence Length: 416
Subcellular Location: Nucleus
EC: 2.7.11.22
|
A1RXB2 | MRISVYACFLGLYFLVFSLIVYVILGAEFLVSVLQPGNVARSMLWVLPAYVANASPVVFSRLVRKRWRLHPMDFGLTFVDGQRLLGDNKTFEGFLGGMLSGVLVGILLAYARFVDGVSAFLLPLGALLGDLGGAFVKRRLRIKPGEPAILLDQLDFVAGALILQGLFSKLPAAEVVVAVVLLTPIVHLLTNMAAFVLGLKDVPW | Function: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Catalytic Activity: 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22173
Sequence Length: 204
Pathway: Membrane lipid metabolism; glycerophospholipid metabolism.
Subcellular Location: Cell membrane
EC: 2.7.7.67
|
Q9KVL2 | MFTVSRLIPDLASANQVLETMDLPHGQSILVQIFSPLSREHVVQLARLIRSRHPQACLLGCSTEEVIFQGEVHHQVTLLQITVFEQTYLSRAVVDYSDDEAADAERLARQLELTSMSRAVVCFSWQMDTLQVARFALRDTQGAPVPVAGGAAKQTPSGRWVLLDEACYQNASVAIALHGEALYVETGGYTEWQPVGRTYRVTAVEGDRVLRLDDEPIEAIYQRNLGAQADLPHDWLISFPLMKGECRHQDLYLPLGLAEEGGLRFNRPLALQDEVRFCFDHPSLTLERVYLTAQQLQAKQCQQVWVFNCALRLNFMHENHELQPLQAVAPTDGCYCWGELLYEHGQQQVMHHSMTFLALREGAVRDDLVPIPLPSYPEGMTSPLFNLIRHAFHDLDAMTDNLAQQIRAQTSLLTASYRRDRRTGLPNRVVLRERLANFAANEHLIALKVTNFNQINEKYGYPVGDKLLRDLSEQFQVFLDQKLAGQSGLYAIGVGEWATVFRAKLDGKSIHSHFYQFVEQLEHVNFEPYGLPNVDYLSISLCAGLVSQGDFAEHSPDELLLRAIEARRYAFNNNHHFCNAARLKVQESVRQERLNWLSRVSRAVVRDDVVVYAQPICQARSHIVASYECLVRIEDEGEIILPGNFLPIITDTHLYTRLSRQMITHTFNMMRHRPEAFSINLSPQDLMSERTLQHLEAAIKSVADPARVGLEVLESEQIKDYGRMIEVCNHFRTLGATIIVDDFGSGYSNIDEIVKLEPQVIKLDGSLIRNIDQDVKQRRIAEQLVKLCQVLNAKTVAEFVHNQTVCRISEDMGVDYLQGYFLGRPSRLG | Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) activity, due to its inactive degenerate GGDEF domain.
Catalytic Activity: 3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)
Sequence Mass (Da): 94055
Sequence Length: 829
Domain: The EAL domain is required for c-di-GMP PDE activity, and the degenerate GGDEF domain is required for full PDE activity of the EAL domain . The GG(D/E)EF motif in CdpA is degenerate, having the sequence GVGEW.
EC: 3.1.4.52
|
Q9HWS0 | MLKRIPVTQLRLGMFVQSLCGSWLDHPFWKRGGFLLDSQADLQRLRESAVKEVWIDASKGLDLPEEAAVSAAAVLPVTMPAGPSPARVALEEEIRHAALLCSRAKAAVVSMFRDARMGQAIDTAHASDLVDEISASVLRHPNALLSLVRLKTSDEYTYMHSVAVCALMIALARQLELPDPLVREAGLAGLLHDIGKMAVPDPILNKPGKLTDPEFGLVRRHPQNGARMLLDCRQVSALVVDVCLHHHERIDGTGYPFGLAQEQISLLARMGAVCDVYDAITSDRPYKKGWNAAEAIRRMAEWNGHFDPQVFRAFVKAVGIYPVGALVRLESGRLGVVLEQHGRSLLTPRVKVFFSARSKVPIPQQVVDLGRAGQTDRIVGFEPAEAWNFRNLDEMWTGLAKSTGSYFDAGTGNP | Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP . Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP . Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture .
Catalytic Activity: 3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)
Sequence Mass (Da): 45419
Sequence Length: 414
EC: 3.1.4.-
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