ids stringlengths 6 10 | seqs stringlengths 11 1.02k | texts stringlengths 108 11.1k |
|---|---|---|
P47818 | MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKL... | Function: Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34250
Sequence Length: 322
Subcellular Location: Golgi apparatus membrane
|
D4B5N6 | MLGGRHSHWSPQDLEEQAFSPYGTFPPSPTESTETSSSISSTRPRVNPRIVSDAILGLSDGLTVPFALSAGLSALGNSRVVVVGGLAELVAGAISMGLGGYVGSRSEVESYEATVRETKHLVKASPMETMNIIHQVFAPYNLPEEPVARMSHILYNSPEKLLDFLLTFYHKESKPGCHQAWISAITLALGYFIGGFIPLIPYFMVDQVLVALYYSIGIMIFTLLVFGYVKTCVVRGWTGKENIVAGIKGGLQMVVVGGLAAGASIALARAINPTGGALF | Function: Vacuolar iron transporter involved in the transfer of iron from the cytosol to the vacuole for intracellular iron storage . Plays an essential role in iron detoxification during high iron conditions .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 29779
Sequence Length: 279
Subcellular Loc... |
Q3IZ91 | MALDVQSDIVAYDAPKKDLYEIGEMPPLGHVPKEMYAWAIRRERHGEPDQAMQIEVVETPSIDSHEVLVLVMAAGVNYNGIWAGLGVPVSPFDGHKQPYHIAGSDASGIVWAVGDKVKRWKVGDEVVIHCNQDDGDDEECNGGDPMFSPTQRIWGYETPDGSFAQFTRVQAQQLMKRPKHLTWEEAACYTLTLATAYRMLFGHKPHDLKPGQNVLVWGASGGLGSYAIQLINTAGANAIGVISEEDKRDFVMGLGAKGVINRKDFKCWGQLPKVNSPEYNEWLKEARKFGKAIWDITGKGINVDMVFEHPGEATFPVSSL... | Cofactor: Despite some sequence similarity to zinc-containing alcohol dehydrogenases, this enzyme does not bind any metals.
Function: Catalyzes the NADPH-dependent reductive carboxylation of crotonyl-CoA ((2E)-butenoyl-CoA) to (2S)-ethylmalonyl-CoA, in the presence of CO2 . This is a key reaction in the ethylmalonyl-Co... |
P30551 | MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAAN... | Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This recep... |
P70031 | MESLRSLSNISALHELLCRYSNLSGTLTWNLSSTNGTHNLTTANWPPWNLNCTPILDRKKPSPSDLNLWVRIVMYSVIFLLSVFGNTLIIIVLVMNKRLRTITNSFLLSLALSDLMVAVLCMPFTLIPNLMENFIFGEVICRAAAYFMGLSVSVSTFNLVAISIERYSAICNPLKSRVWQTRSHAYRVIAATWVLSSIIMIPYLVYNKTVTFPMKDRRVGHQCRLVWPSKQVQQAWYVLLLTILFFIPGVVMIVAYGLISRELYRGIQFEMDLNKEAKAHKNGVSTPTTIPSGDEGDGCYIQVTKRRNTMEMSTLTPSVC... | Function: Receptor for cholecystokinin. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Has high affinity for CCK-8 and low affinities for gastrin-17-I, CCK-4, and unsulfated CCK-8.
Location Topology: Multi-pass membrane protein
Sequ... |
P0DOA0 | MRPKWCKTTVLASFPRGSACTARQLKHSANRIYLDARASVPARRAGILNEDRIELPDDAIGASAERRSTRDLRKPSRAGIQHERAVGLMSRQTDNTYPKPLVMPKRGPSAALRLLIVGILLMGAAFIYFLFRDQLGDGFALVLMGVLSMVGVFYLFGAATGLIQFSQRSDHQDLAHSFMDTQPEGTVISDPRGQIVYANQAYARMTGATDADGIRPLDQVLASEPAASDAIYRLTNAVRDGLSAQEEVRISGGLSRGANGSLAPVWYRIKARALEGGAEFKGPLVAWQVADISEERAEQERFFQELQEAINHLDHAPAGF... | Function: Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CckA autophosphorylates in the presence of ATP on a conserved His residue and transfers a phosph... |
Q9TS44 | AVQKVDGEPRAHLGALLARYIQQARKAPSGRMSVIKNLQNLDPSHRISDRDYMGWMDF | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecys... |
O93464 | MNAGICVCVLLAALSTSSCLSLPAVSEDGGQSDLGIVMEHTRHTRAAPSSGQLSLLSKAEDDEEPRSSLTELLARIISTKGTYRRSPSPKSKSMGNNHRIKDRDYLGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut (By similarity). Induces the secretion of gonadotropin and growth hormone from the pituitary. Suppresses food intake and decreases the expression of preprosomatostatin genes in the forebrain.
PTM: The precur... |
Q9PU41 | MYGGICICVLLAALSVSSLGQQPAGSHDGSPVAAELQQSLTEPHRHSRAPSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.
PTM: The precursor is cleaved by proteases to produce a number o... |
P06307 | MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
PTM: The precursor is cleaved b... |
O57312 | MTAGLCVCVLLAVLCTSCLGHPISSQHLDEGQRSISTPSEALLEADTHSLGEPHLRQSRSAPQLKSLPVAEEDGDSRANLSELLARLISSRKGSVRRNSTAYSKGLSPNHRIADRDYLGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity).
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 14773
Sequence Length: 135
Subcellular ... |
Q9PU29 | MYSGICICVFLAVLSASSFGQQTAGSHNGNPLAAELEQSLTEHHRHVRAPSSAGPLKPVPRLDGSIDQRANIGALLAKYLQQARKGPTGRISVMGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS | Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity).
PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence Mass (Da): 14273
Sequence Length: 130
Subcellular ... |
Q21QL9 | MKTVPTLSFSKLGCSRGGRQLFQNIDCVLESGHWLYVAGANGVGKTSLLRMVCGLAPIESGEIFWNGTPIHAQADAYRQDLCYLGHLNALQESMTVHENLAFTAALGGMAPDMAQTQSVLAHFGVAGRDRQLVRHLSQGQKRRVALSRLALSQARLWVLDEPFVAMDEAGVRMLADLIAAHLTQGGLAVLTSHQQVDIGAIPAQLLELRA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q0VR80 | MSQPATHSDAEPATRLVLEQLSCERDDRLLFSGLSFTASAGEIWQITGANGAGKTTLLRILVGLHGFYEGERQWWQPQWQQQLLYLGHEPGVREELNPLENLRYACALSQQGGDPMAALAAVGLQGFEEVPAAHLSAGQKRRIALARLWLDRKAVWVLDEPYTAIDQDGVAALDQQIQQAAEAGTLVIYTSHHQVGDGVRRLHLAHGQAEVTEGGRV | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q5E3S7 | MLEIRNVTCIRDERVLFERLNFTISDGELIQIEGQNGAGKTTLLRIIAGLGYADEGDIFWKNESIKQNREEFHSDLLFLGHHTGVKRELTAFENLAFYQSMHDNYNEAAIWDALARVGLAGREDVAAGQLSAGQQRRVALARLWLSNHKLWILDEPLTAIDKQGVKVLEKLFMDHAKQGGIVLLTTHQDLFIDSNELKKIRLGE | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q0A808 | MGDTALHLVAAPALEATGLQVARGGRPLFRGLGFRLARGGLLCVRGANGSGKTTLLRTLAGLSRPHRGRILRAGRCIRQAANDHRGTLQYRGHRDGLRGALTVLENLQWQAALYHHRPDREAVRTALAGMGMARHLDTLASQLSQGQRRRVVLASLALFPRCRLWLLDEPQAALDVEGAERFHALLARHCQEGGAVVACSHQHLRIGGIPCDELWLSDPAPAGARSAGDRVTGTEA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q5PBP5 | MLECSDVSCIRGDRLLFENLSFVAKGGSITLVVGNNGSGKTTLLRTIVGLIPAASGSVRLDGEDITISSKCILQITYVGHKSACTGNMTVQEILEFWAQCRGTGELIDAAACFFGLYPILDVRFKNLSSGWQKRVALSRLLVSNTRVWVVDEPFSNLDPDAVALVQNLILTRAERGGIVILADHKKNDLFTDAQIVQIPPTDCGTHST | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q5P3L0 | MVKSTPMLYAADLACLKGDRLLFRGLSLHVAPGAMLRIAGPNGFGKTSLLRILCGLAHPEAGEIRWNGRPIAGDRESFHRTLLYLGHAPALNDLLTPLENLRFACAAAGDDVDEDACVDALVRIGLADQLDLPARVLSQGQRRRVGLARLFLGIRRSLWVLDEPFTALDAAAVADLATTLSDHCAAGGVVILTTHQDAPFAVPPTVLDLSEVAA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q6G529 | MVLSGKDLTAYRNEDVLFQGLSFCLFPQQLMTITGPNGIGKSTLLRIIAGLFKAAEGHVSLKDQEQIYPVATACHYLGPQNAMKPFLSVIDNLQFWSAFYGQPLHSPHEVLADIGLSDLEHVPFNVLSTGQKRRIAIARLLLSYRPVWILDEPISGIDSYAQTLLTNIFQYHLNQGGMIIAATHSPLGIPENHKITLEKFLPPQEKIQ | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q7WIP8 | MQNAEAAPALLAAHGLVGRRGGRRPLDLNLRPGQLVHVRGANGSGKTSLLRTLAGLLRPRRGEVRWNGADIHADLPGYYLHMAYLGHDNGCSDALTARENLRYALHVAGAPRAEPELERALRDWGLAAGADAPAARLSQGQGRRLALARVMLSRKRLWLLDEPDAGLDAASLQRLHGMLDAHLAGGGAAVLASHRGGGAWAGCTQTLELDEYAHAEVVGADCLA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
P30963 | MQLSGRRVICVRGGREVFAGLDFEAVSGEAVAVVGRNGSGKTSLLRLIAGLLIPAGGTIALDGGDAELTLPEQCHYLGHRDALKPALSVAENLSFWADFLGGERLDAHESLATVGLDHATHLPAAFLSAGQRRRLSLARLLTVRRPIWLLDEPTTALDVAGQDMFGGLMRDHLARGGLIIAATHMALGIDSRELRIGGVA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q8YEM5 | MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVKLTEGTQIVPVRAACHYLGHQNAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVEHLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKASEARFAELMREHMRQDGMIIAATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q9A298 | MLRAVLIKDLAISRGERTLFSKLDLTLRAGEAATLVGRNGAGKTSLLRAVAGLLRPAAGSTAFEDANGPVEADTARAEHLHMLGHQDGLKSSRTAWEELRFQTLWTGGNEDSARAAAQRFDLRRLLDLEVRRLSAGQRRRLALARLAASPRSLWLLDEPMAPLDAGQRAAFGAVMAEHVAGGGMILASVHDPLPIPARSVEVGA | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q87MK8 | MLEVSNLTAIRDERVLFENLQFEIKPGELVQIEGRNGTGKTTLLRIITGLGDREEGMIKWKGEEVEKSRDVFHQDLLFLGHQTGVKRELTAFENLRFYQSIQNNSTSDEEIFTALTQVGLAGREDVPVAQLSAGQQRRVALARLWLSKQILWILDEPLTAIDKQGVKVLEALFAQHADNGGIVMLTTHQDMFADSPKLRKIKLGD | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q73HX8 | MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRHCGKDIYDDPKSYISSMVYIGHKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPVLNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDSATCELVLNLISIRSEQNGIVIITGHSSTEQLCDFTTIDIRNFNRLLV | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q9PAP0 | MLCQYLPPDDRPPSSAPPLLAAHALTYSRNATPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIDINTHHNTTAPERTRHIAYLSHLPGLKQDLSALENLHFLNALHGYHPQRTPSNALTLVGLTDHAQTLVRQLSAGQKKRLSLAQLWLSPAPLWLLDEPYANLDPEGITLLNHILTAHIHTQGGTLLTTPGARPTLPVPTRLLHLKKAP | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q668T8 | MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDNNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFVQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
Q5NQX0 | MGRKRLSDFGNARLACHDVSCLRGDRLLFTHLSFEVKAGEAVLITGANGIGKSSLLRLLAGFLKPFSGHIEKWGRVAFADEALAMDRHLPLEKALAYWAALDGVLGAEKEAMAVMALDILADSPVRLLSTGQRKRAVLARLLASQAAIWLLDEPANGLDAASVRALIEMIEHHRQKGGIILAVSHQGLDMADYKTLSLENFVANSGQSSGFFDLLDESHFS | Function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic Activity: ATP + H2O + heme b(in) = ADP + H(+) + heme b(out... |
P93280 | MRRLFLELYYKLIFSSTPITSFSLFLLYIVVTPLMLGFEKDFLCHFHLGLIWISLLFSFLSAPFFRNEKEDGTLELYYLSTYCLPKILLLQLVGHWVIQISCVFCGFPMLQLLYQFGRSGMDWLNILLGSLVLTLLCGIHSCLALGITSSSGWNSLQNLTTLPTLLPLTVFCTSIETEWFHVLLLIGYFFLFVSLFPILVSISLQD | Function: May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23637
Sequence Length: 206
Subcellular Location: Mitochondrion membrane
|
P30964 | MTALSALIRRDIRIALRVGGGALIGVLFFLTVVVLMPFAVGPDLALLSRLGPAILWLGALLASLLTLDRLFMADHEDGSLDLITMSRTPLELACAAKALAHWLAAGLPLIVATPVLGLLLNLDMVATGAVALTLLAGTPALTFTGMIGAALAVTLHRGGLLMAVLVLPLSIPVLIFGVAASQAVIVGPMSFGAPFSILCALSLVSLVIGPFAAAASLRHGLD | Function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22668
Sequence Length: 222
Subcellular Location: Cell inner membrane
|
P0ABM0 | MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ | Function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23619
Sequence Length: 220
Subcellular Location: Cell inner membrane
|
Q9I3N3 | MNPVRKKRLIIVLAIVAGVGAAVGLALSALQQNINLFYTPTQIANGEAPTDTRIRAGGLVEKGSLQRSEDSLNVRFVVTDGAKEVTIAYHGILPDLFREGQGIVALGKLGGDGVLVADEVLAKHDENYMPPEVTKALKDSGQLKHYENGKAAGETSYNQEGK | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 17239
Sequence Length: 162
Subcellular Loc... |
Q8GQ96 | MKPRNRRIALIVAGLSALGIATALVLNAFQSNLVFFFTPSQVSAGEAPLERTFRVGGMVERGSLKRQRGELAVQFVITDTVKAIPVTYSGILPDLFSEGKGVVVQGRLDSAGLFRAEEVLAKHDENYMPPEAQHALDEVQKKPASRKP | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 16103
Sequence Length: 148
Subcellular Loc... |
P0C1F6 | MNPLRRKRLLIILAILAGVGIAVGLAMSALRENINLFYTPTQIANGEAPLDTRIRAGGMVEQGSLKRSGDSLDVTFVVTDFNKAVTITYRGILPDLFREGQGIVALGKLNADAVVVADEVLAKHDEKYMPPEVTKALKDSGQSRLARIRSLPRRAK | Function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Location Topology: Single-pass type II membrane protein
Sequence Mass (Da): 16967
Sequence Length: 156
Subcellular Loc... |
P48745 | MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQI... | Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival . Acts by binding to integrins or membrane receptors such as NOTCH1 . Essential regulator of hematopoietic stem and progenitor cell function . Inhibits myogenic diffe... |
Q64299 | MSLFLRKRCLCLGFLLFHLLSQVSASLRCPSRCPPKCPSISPTCAPGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEGDNCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQLDVLLPGPDCPAPRKVAVPGECCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDKKGKKCLRTKKSLKAIHLQFENCTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQCLPGEIIKK... | Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differen... |
P78396 | METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYT... | Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the... |
Q0WKY2 | MSGYERKNTTANSITITKRKRNSISEQSENVYEKSNRKESITLKPHRSFTPGFSQRDCKPVRHSKSSLRRRRRTKEKISSSVEREWVFSANNFENLADKLVLVSYNLLGVDNASNHMDLYYNVPRKHLEWSRRKHLICKEISRYNASILCLQEVDRFDDLDVLLKNRGFRGVHKSRTGEASDGCAIFWKENLFELLDHQHIEFDKFGMRNNVAQLCVLEMNCEEDPKSKLRVRSSDPRRLVVGNIHVLFNPKRGDIKLGQVRLFLEKAYKLSQEWGNIPVAIAGDLNSTPQSAIYDFIASADLDTQLHDRRQISGQTEVE... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 52152
Sequence Length: 454... |
Q8VYU4 | MRRSRFVAQVFSDVTFADASTISAPIFTMSTRAPYRGARGRGRGRGGRSFSDRPYNDDAGRDQFVTGDSHFQSVHDANFRFRHGEPYRQHQPPLDQRQQPPFNQNYEFRPPPPSRGQWQQFRQPNQFPSNQNYAACPPPPFYQNQMSRPPPQQSFRQRPRSKPSDYREWEYAKTPPSPGSEKFVVLSYNILADYLANDHWRSLYFHIPRNMLSWGWRKSKLVFELSLWSADIMCLQEVDKFQDLEEEMKHRGYSAIWKMRTGNAVDGCAIFWRSNRFKLVHEESIQFNQLGLRDNVAQICVLETLLTSHTKENETPPPES... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Sequence Mass (Da): 84925
Sequence Length: 754... |
Q4WQG5 | MYSQTHQGQHVMMNGGQAHQRFGMQIPKFQSQSHHPHHTQQPHHHTHHNQASHNINHQHNFSSGALASATPHFTPSHIQNGAHTNVDEDIDESMNEHWQQQLQLAAESRQASSPHYHARSVAQQAKGIQIAPSQPETQEQVPDGQNGVVKAKASSRQGWHALDFGGQGLRALSTSLFNYIFLEKLYLNHNKLKALPPAIGQLRKLNHLDLSGNDLTELPEEIGMLTNLKKLYLFDNNIRTLPYEMGYLYRLETLGVEGNPLNDVLKSHIMKEGTKALIKYLKEEMPAFFFSCTTPLTLMAVHLPPPDRDWIVLDETASSS... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
Q5A761 | MNITNKFQHTPIQGQPQSNLQAQQILLSQLHQGQAQQQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESLNQNIYQNNYQRAQPSLQQQFFPQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPSSQQFYSQQQASVLQQQQQQQIQLQSAHQQQSSLLNMNSINVDNPNSVYWQHQQQLCQISRGSNVPHYYARQYASNSRKAKNPYSEVKSVGLVEATRSMVASLEDEEEKKKKPINYQGTPTTSAALLHNKKSTQDIFEDDSMEEQRMRLKTQGKQLWCQLDLSGQGLVNISSKLFHYDFLESLY... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
P0CP22 | MFYPHHQSQQSTTTNPSKHHDSQDVRLPGTSSWSRHPSHPSFTPSLPMPSPSGYPPLGSGYPPGGHHHPNVNVHSGIHGPHPSFGSGMGGNGGMGHGQGFGMGMFQNGVQTSPPRGEPVPMTSHWQTQMMRAEASRSASSPHHRARAAAISSRATNKPSAVPIVDPNNRPSSSYGTNGLHRKNASSVFNGEPTGTPPLSDPSLTPAQNPAEPATPAPVAGQTESKDEEKPNEPWTGLDLGGIRLKRLSTALFSFTHVTSLYINHNALTSIPSAISSLRQLTLLDATGNELSTIPSEIGVLSKLKDLLLFDNNLTTLPFEL... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
Q5B778 | MYSQTHQQQHVIMNGGQAHQRFGMQMKFQTQNHHPHPAQQPHHHAHHNQPPQHVGHQHNFSSGALASATPHFTPSHIQNGTHTNIDEELDESMNEHWQQQLQLAAESRQASSPHYYARAVAQQTKGIQIAPSQPEAQENGVNQKNGITKTKPASRQGWHALDFGGQGLRALAPSLFKYAFLEKLYLSHNKLKVLPPQIGQLRKLTHLDLSANDLTELPEEIGMLTNLRHLLLFDNNIRTLPYEMGYLYRLEILGIEGNPLEDVLKSLIMKEGTKALIRYLKEEMPVHVPPPARDWLVLDETAATSPDKVSVLSYNTLCDS... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
Q8SU52 | MAEECLVSRKKFGGKAMEVRSEMWTGLDLCSQGIKNISKSLFDMRFIRTLNLANNEIEVIPREICNLRHLEVLNLSKNKIRSIPPEIGKIVSLRELNLSDNLISNIPMEMGTLYNLEVFEIANNPLIVPFNTLIRDKKLLQFCREHNTGYPPPNDRLWIECTGKNVFYGDTVSVGTFNILSNIYATRMTYAPSWVINSEFRREGVLQEIVLYNVDILCLQEIELYSFFDFYKEQLEMRCNYDSIIYPRGRVKSVPDKKNVDGCAIFWRRSKFRLIAQFPIDFHQKVIQDTRFNTNQELLDRYGKKDNIAIGALLERPNGQ... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
B7XK66 | MEEKIKKKDYNKDIDNCDDELEGLDMSFQGIKVIGKEITLLVSLKQLILNNNDIETIPEDISNLIRLEVLDFSYNKIEKIPTELGRLINLKELYLNNNMIVEVPMELGTLYKLENFSILNNPLVHPYGIMSKDKSLLRFCRENNTNYKQPNDRVWIDTVLKIDQSLETYSFGTFNILCSLYASNLTYAPSWVINLECRKDILMQTFIAYNLDILCLQEVDINVFNTFYKEQLAQKLDYDGVILPKKSFDKVTDQPKKFHGIVTFWKKNKFKLIEQVSIDFFQKIINDKRFKYLSDIHTRIFQKTNVGLITIFETCNTNII... | Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also lo... |
P51679 | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFK... | Function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocyt... |
Q7VA54 | MKYLRKIINWLSSLKVAIVLLILIALGSALGTALPQGEKAESYLKNYEVTRFLGVINGDLLLQLQLDHVYSSFWFLFLLTWLSFSLIICSWKRQWPSLKKAIDWIDYKEPKQIQKLAISQSFRIQKNDNGINPLANYLENNGWQVKIKSSRLAARKGLIGRVGPPLVHFGLILLIIGATYGVLKGQRLEKFLAPERSLNLLSPNGISKVSVKLTDFKIDRDPTGKPEQFRSKLELHNNNINKSIYEEISVNHPLRFQGITLYQADWSLAAITIQINNSPKIQFPLNKIDELGDQVWGIVLPQMPDSDLKPLLLTLSSEQG... | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48044
Sequence Length: 429
Subcellular Location: Cellular thylakoid membrane
|
A6MVS2 | MLIKINQYFRKSISVLGNLKLAIILLLMLALFSAFGTVIEQNQNVAFYENSYPNSAPLFGFLSANAILFLGLNNIYQTWWFTTLILLLAVSLFSCTLARQIPSLKMARLWQFYTKDQSLKKIGLSFNLQKTSLSKLAFTLKTDDYNVIQKGRFLYAYKGLPGKIGPIIVHASLIIILFGALLGNLSGFVSQELVPLGGVFHIQNIINSGTLSYVPQNFEGYVKDFKIAYNDEGSIDQFYSDLSILNSTGEEVRSKTIYVNEPLRYEGIVFYQTDWSITNLAINVDQQTNIQLPLKSINVKGEGKFWIASLPIANVEKATN... | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 49475
Sequence Length: 441
Subcellular Location: Plastid
|
Q31RG5 | MTSDPLASPSFADRWRRGQQLFWTWLADLRLAILLLLAIAIASATGTVIEQGQSLAFYQENYPTDPALFGFLSWRWILSLGLDHVYRAGWFLGLLILFGASLTACTFRRQWPALRAAQRWQFYQEPRQFTKLALSASLPQGKLDSLEPLLLQRRYRLFRADDVLYARRGLAGRVGPILVHAGMLVVLGGAIWGSLGGFYAQEMIPSGETFQVRNIVDAGPWSGSRIPQDWAVKVNRFWIDYAPDGRIDQFYSDLSVVDREGQEQDRQTIHVNQPLRYGGLTFYQADWAIAAAQVRLNNSPVLQLPMAQLPAAGRIWGTFV... | Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50461
Sequence Length: 456
Subcellular Location: Cellular thylakoid membrane
|
P38273 | MRLHYITVFDPSRSTNENDTFKQLLLFHYFGTTDSIPSLNEKLSIIGVIQGIWSLTSSCVNKDGEDLEKIIELNNDIIFCIKVESRFFISLAISNISDDQSAIPLQYLSAYLWLSYRFFKLLNGSFSGFNKDFRKLTDLLNEFVIPFWNDIYLNLETVTNRSFTVMWPGFYKRANFQHSSYNPGEKNNVEESWDAIILQNILLDKKSYLGLKDILVYHLPKRTKAANRESMGTKTYGLVRNFTSDLNTLPDISNWLYHLHCTYGEISSHILTGNVHFKEELQVEEEQERSRDTNGRDEEESQEQQRREHQETTQNNTSEL... | Function: In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming a... |
Q3C2E2 | MTTPRNSMSGTLPVDPMKSPTAMYPVQKIIPKRMPSVVGPTQNFFMRESKTLGAVQIMNGLFHIALGSLLMIHTDVCAPICITMWYPLWGGIMFIISGSLLAAADKNPRKSLVKGKMIMNSLSLFAAISGIIFLIMDIFNITISHFFKMENLNLIKAPMPYVDIHNCDPANPSEKNSLSIQYCGSIRSVFLGVFAVMLIFAFFQKLVTAGIVENEWKKLCSKPKSDVVVLLAAEEKKEQPIETTEEMVELTEIASQPKKEEDIEIIPVQEEEGELEINFAEPPQEQESSPIENDSIP | Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/... |
P11836 | MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP | Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor... |
Q15762 | MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTRED... | Function: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell . Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IF... |
Q8K4F0 | MAYVTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSFYNASEADIGIYSCLFHAFPNGPWEKKIKVVWSDSFEIAAPSDSYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRQTRSNCSQGSMKSILIIPNAMAADSGLYRCRSEAITGKNKSFVIRLIITDGGTNKHFILPIVGGLVSLLLVILIIIIFILYNRKRRRQVRIPLKEPRDKQSKVATNCRSPTSPIQSTDDEKEDIYV... | Function: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFN... |
P20273 | MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRS... | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same ... |
P35329 | MRVHYLWLLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSKVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSV... | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same ... |
Q9N1E6 | MHLLGPWLLLLVLEYLAFSDSSKWAFEHPETLYAWEGACVWIPCTYRALDRDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHVNDSGQLGLRMESKTAKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGESVTMTCEVSSSNPEYTTISWLKDGTSLKKQNTLMLNLHEVTKDQSGKYCCQVSNDVGPGRS... | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be i... |
Q9N1E3 | MHLLGPWLLLLEYLAFSDSSKWAFEHPETLYAWEGACVWIPCTYRALDGALESFILFHNPEYNKNTSKFDGTRLYESTKDGEVPSEQKRVQFLGDKSKNCTLSIHPVHVNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWFLEGVPVGQAAVNSTSLATKSVFTRSELKFSPQWSHHGKIVTCQLHGADGKFLSNDTVQLNVKHTPKLKIEVNPSDAIVREGDSVTMTCEVSSSNPKYTTVSWLKDGTPLKKQNALMLTLQEVTKDQSGKYCCQVSNDVGPGRSEE... | Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be i... |
Q9BZW8 | MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFESLLPDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRRNHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLI... | Function: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and inte... |
Q07763 | MLGQAVLFTTFLLLRAHQGQDCPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAKLQDSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQLFLSCLVTKDDNVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHGCQSVPSNFRFLPFGVIIVILVTLFLGAIICFCVWTKKRKQLQFSPKEPLTIYEYVKDSRASRDQQGCSRASGSPSAVQEDGRGQRELDRRVSEVLEQLPQQTFPGD... | Function: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and inte... |
P01731 | MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICYHRSRKRVCKCPRPLVRQEGKPRPSEKIV | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are de... |
P07725 | MASRVICFLSLNLLLLDVITRLQVSGQLQLSPKKVDAEIGQEVKLTCEVLRDTSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLNDILDPNLFSARKENNKYILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGTPRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRRVCKCPRPLVKPRPSEKFV | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are de... |
P79336 | MQPGLWLLLATQLAALRGSSVLQQAPGSVMVQTNGMVIMSCEAKTSPTSTRIYWLRHRQAPSPDSHYECLAYWDPIKGIVYGQEVEPEKLTVFPDATRSILNLTSVKPADSGIYFCMTVGSPELTFGKGTRLSVVDVLPTNSQPTKKPTPRKKMCRPPSPVTQKGPSCGLLTLGLLVAGVLVLLVSLGVAIHLYRLKRRARLRLLKQFYK | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are de... |
P10966 | MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK | Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are de... |
P14209 | MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK | Function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (... |
Q8VCN6 | MARAAMEAAATVVLALALLGAAARGAASDDFNLGDALEDPNMKPTPKAPTPKKPSGGFDLEDALPGGGGGGAGEKPGNRPQPDPKPPRPHGDSGGISDSDLADAAGQGGGGAGRRGSGDEGGHGGAGGAEPEGTPQGLVPGVVAAVVAAVAGAVSSFVAYQRRRLCFREGGSAPV | Function: Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 16783
Sequence Leng... |
P21926 | MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion . Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the mo... |
P40240 | MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRSKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion . Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the mo... |
Q8WMQ3 | MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNNSSFYTGVYILIGAGALMMVVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDQVIKEVQDFYRDTYNKLKGKDDPQRETLKAIHYALDCCGLMGEVEQLLADICPQRDVLSSLPMKPCPEAIKEVFQNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein compl... |
P40241 | MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRNKDEPQRETLKAIHMALNCCGIAGGVEQFISDICPKKQVLESFQVKSCPDAIDEVFHSKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV | Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein compl... |
O65896 | MDKPSFVIQSKEAESAAKQLGVSVIQLLPSLVKPAQSYARTPISKFNVAVVGLGSSGRIFLGVNVEFPNLPLHHSIHAEQFLVTNLTLNGERHLNFFAVSAAPCGHCRQFLQEIRDAPEIKILITDPNNSADSDSAADSDGFLRLGSFLPHRFGPDDLLGKDHPLLLESHDNHLKISDLDSICNGNTDSSADLKQTALAAANRSYAPYSLCPSGVSLVDCDGKVYRGWYMESAAYNPSMGPVQAALVDYVANGGGGGYERIVGAVLVEKEDAVVRQEHTARLLLETISPKCEFKVFHCYEA | Cofactor: Binds 1 zinc ion per subunit.
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Functions as a conventional cytidine deaminase. Has no affinity for RNA and is not involved in RNA-editing by C-to-U deamination.
Catalytic Activity: cytidine + H(+) + H2O = ... |
G0SDN0 | MAPRRRRGAGQDGSDDGRSDSDAPKNRPPNTAFRQQRMRAWQCVLTPKLIVTVFSILAAIYLGFGAWLTYLAHTVRDLKIDYTDCLTSAPKDDFETIPQNHITAHFSAKDSTFDPYKAQWKTTEREVQVANYTDNRQFCIVRFNIPEDLQPTISFFYYLENFYQNHRRYVNSFNAKQLLGDAVDGKTINDSTCDPITHDPKGTGKIVYPCGLVANSIFNDTFSSPLALAVRNSSDSSRPYNMTTKGIAWPGLKDLYGKTSYSLDQIVPPPNWERRYKYGYQENNPPPDLKTDELFQNWMMLAAAPNFYKLYQKNDTHPML... | Function: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and phosphatidylserine from the lumen to the cytosolic leaflet of membranes and ensures the maintenance of asymmetric distribution of phospholipids.
Location Topology: Mult... |
S7WII9 | MGENSTTGLRGQADVSQFSDAAVEPTLSSPPTGQRQQSLPLFGEETCSISSAPSVGGGGGWPFQRQGSSRLTSRGTSLSSCSDAGSGLGALRQREDSFPEYHGVGLPLGGKYALDGTGLVLAPRVPFIFSHQLPSLTGLDEAGFSDTRKVPSTYQALAARFVHQVHQEAGNGMYPLWSAGVVLRLCLLGALFFVSVGAWLIFEDEQHVECKLNYAEKTLQEGSSRYLLKGISSAHCTREVNELKGEEISVYAEMGHFFQNDAQVLWSRNDRQLAGKIFTDPKDVRECEPLATAVVGNVTKVLHPCGALAWAVFTDKYQFL... | Function: In tachyzoites, required for the cellular trafficking of guanylate cyclase GC and UGO to the cell membrane . May play a role in the folding of the GC P-type ATPase-like domain to sense vacuolar changes in phosphatidic acid and pH levels which trigger parasite egress .
Location Topology: Multi-pass membrane pr... |
P25656 | MVSLFKRGKAPPLTKEGPTSKKPPNTAFRQQRLKAWQPILSPQSVLPLLIFVACIFTPIGIGLIVSATKVQDLTIDYSHCDTKASTTAFEDIPKKYIKYHFKSKVENKPQWRLTENENGEQSCELQFEIPNDIKKSIFIYYKITNFYQNHRRYVQSFDTKQILGEPIKKDDLDTSCSPIRSREDKIIYPCGLIANSMFNDTFSQVLSGIDDTEDYNLTNKHISWSIDRHRFKTTKYNASDIVPPPNWMKKYPDGYTDENLPDIHTWEEFQVWMRTAAFPKFYKLTLKNESASLPKGKYQMNIELNYPISLFGGTKSFVLT... | Function: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylserine and small amounts of ethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids ... |
Q12018 | MSETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRR... | Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugat... |
Q99459 | MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIA... | Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes . Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is require... |
Q8SWM6 | MSTKVELYMEIGTVITDLEYHTKYMLKKLLGRGAYAQCYLAEIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKLDNPNVVKMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSKKEHFLMKIYRNLMTNRTEEGVVDTDYVLFSIPVTKLRGV... | Function: Protein kinase required for the cell cycle where it is involved in mitotic exit. Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated... |
P32562 | MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKRLDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSL... | Function: Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O... |
O27463 | MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGKTGTGKTAVAKFAMKQLKEASKDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGWTKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGDGLLYTLTRTDNVSILSISNYVEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAAKEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVLEAILYLTKRKEEITSGRLYE... | Function: Involved in regulation of DNA replication. May play an essential role in origin recognition. Binds to DNA, with a preference for origin-specific double-stranded sequences. Does not bind single-stranded DNA. Inhibits MCM helicase activity but does not affect its oligomeric state.
PTM: Autophosphorylated on a s... |
Q3YL95 | MKKKLFALLKYIIFFPMLCTVLGLLGIPIGLIVNFLRTGSFDFNLKDEIDVVLFTLKIGIPIGFILGLGLWGLSILDRK | Function: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against Cd... |
Q74RU7 | MKNLLYVVLLMAVCILGLLIVGTIFYLFLEVFMYFYVNAPISLESFQFTRLLKMSIYGGGILGLGIGLLRIFKIKGF | Function: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against th... |
Q54HX8 | MGQDNINLNKVDGQPSSPPQEQQQQQQYPPQGYPQQQQYPPQQGYPPQQYPPQQGYPPQQYPPQQGYPQQQPPQQYPAPVGAPQQPYMATQQVVVQQVYVQPTFGVVPVDCICQHCQTRMSTKTSYKSGSMVWLVCVLLIIFGCWLGCCLIPFGIDSLKDVQHKCSHCKKVLYRFDRMSGK | Location Topology: Peripheral membrane protein
Sequence Mass (Da): 20589
Sequence Length: 181
Domain: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Subcellular Location: Late endosome membrane
|
Q9H305 | MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPLPPADIGPPPYEPPGHPMPQPGFIPPHMSADGTYMPPGFYPPPGPHPPMGYYPPGPYTPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC | Function: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 21892
Sequence Length: 208
Domain: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphip... |
Q00534 | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNT... | Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and ... |
Q64261 | MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQST... | Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and ... |
G5EFV5 | MSRRYDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKLTDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYMALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQPQKRSRRLDDDG... | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequen... |
P51953 | MALDVKSRAKLYEKLDFLGEGQFATVYKARDKTTNTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLLCFMETDLEVIIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLDQLTGIFEALGTPTEETWPGMSNLPDYVSFKLFPGTPLEHIFSAAGDDLLELLKGLFTFNPCTRTTASQALKMRYFSIRPGPTPGPQLPRPNSSTEALKEKE... | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent ph... |
P54685 | MDKYNIEALIGEGTYGVVSRATVKATGQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDHPATPFKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLLQQRQVLAQV... | Function: Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 40567
Sequence Length: 360
Subcellular Location: Nucleus
EC: 2.7.11.2... |
P50613 | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQ... | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent ph... |
P20911 | MEGIAARGVDVRSRAKQYEKLDFLGEGQFATVYKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPGMSSLPDYVAFKSFPGTPLHLIFIAAGDDLLELLQGLFTFNPCARCTASQALRKRYFSNRPAPTPGNLLPRPNCSI... | Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent ph... |
P0C661 | MIDENFKKKLAVSRERVEDLFYFENSKEIGRGTYGLVYKAVPKHSNGRFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKTKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGGPDMRGRVKIADLGFSRIFANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDTDWPDMKKMPDHQRLLNDARNEGTPIQTFPNSLQRYFDKWKINSQSSPYR... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
P90866 | MTLMIDENFKKQLAQRRERVEDLFYFENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSS... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
Q95YH0 | MNTHNQSSNQNGGGSGGGGGGGGSSTFSPIVLTSTYRLDVQEKYTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQ... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
Q9VT57 | MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDP... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
P49336 | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
Q8R3L8 | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
Q66KH9 | MDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDRDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDFAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIKKMPEHSTLIKDFRRNTYTNCSLIKYMEKHKVKPDSKTFHLLQKLLTMDPIKRISSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKG... | Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited t... |
A1RXB2 | MRISVYACFLGLYFLVFSLIVYVILGAEFLVSVLQPGNVARSMLWVLPAYVANASPVVFSRLVRKRWRLHPMDFGLTFVDGQRLLGDNKTFEGFLGGMLSGVLVGILLAYARFVDGVSAFLLPLGALLGDLGGAFVKRRLRIKPGEPAILLDQLDFVAGALILQGLFSKLPAAEVVVAVVLLTPIVHLLTNMAAFVLGLKDVPW | Function: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Catalytic Activity: 2,3-bis-O-(geranylgeranyl)-sn-... |
Q9KVL2 | MFTVSRLIPDLASANQVLETMDLPHGQSILVQIFSPLSREHVVQLARLIRSRHPQACLLGCSTEEVIFQGEVHHQVTLLQITVFEQTYLSRAVVDYSDDEAADAERLARQLELTSMSRAVVCFSWQMDTLQVARFALRDTQGAPVPVAGGAAKQTPSGRWVLLDEACYQNASVAIALHGEALYVETGGYTEWQPVGRTYRVTAVEGDRVLRLDDEPIEAIYQRNLGAQADLPHDWLISFPLMKGECRHQDLYLPLGLAEEGGLRFNRPLALQDEVRFCFDHPSLTLERVYLTAQQLQAKQCQQVWVFNCALRLNFMHENH... | Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an ... |
Q9HWS0 | MLKRIPVTQLRLGMFVQSLCGSWLDHPFWKRGGFLLDSQADLQRLRESAVKEVWIDASKGLDLPEEAAVSAAAVLPVTMPAGPSPARVALEEEIRHAALLCSRAKAAVVSMFRDARMGQAIDTAHASDLVDEISASVLRHPNALLSLVRLKTSDEYTYMHSVAVCALMIALARQLELPDPLVREAGLAGLLHDIGKMAVPDPILNKPGKLTDPEFGLVRRHPQNGARMLLDCRQVSALVVDVCLHHHERIDGTGYPFGLAQEQISLLARMGAVCDVYDAITSDRPYKKGWNAAEAIRRMAEWNGHFDPQVFRAFVKAVGI... | Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP . Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP . Acts in regu... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.