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Q668V1
MGASATNSVTHPAFTLNVRPDNIGIITIDVVGDKVNTLKAEFADQIATILQQAHALPKLQGLVIVSGKPDSFIAGADITMIAACRTAHDARVLAQKGQSILAQIAAFPVPVVAAIHGACLGGGLELALACHSRICSLDDKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSKALDMILTGKQIRPRQALKMGLVDDVVPRDILLDVAIQRAKAGWLNRRALPWQERLLSGPLGKALLFRIVRKKTLAKTRGHYPAAERIIDVVRKGLDQGGPSGYEAEARAFGELAMSPQSAALRSLFFATTSLKKETGSAATARAIHRVGVLGGGLMGGGIANVTATRAGLPVRIKDINPQGINQALKYTWDALGKRVRSKRMRPTEQQRQMMLISGSTDYRGFERVDIVVEAVFEDLSLKQQMVADIERFGAAHTIFASNTSSLPISQIAALAQRPEQVIGLHYFSPVDKMPLVEVIPHEKTSEETIATTVALARKQGKTAIVVADRAGFYVNRILAPYINEAARCLLDGEPIESVDNALVDFGFPVGPMMLLDEVGIDVATKIMPILVEQLGPRFAAPPSFDVILKDGRKGRKNGRGFYLYSNPTLHSNSTKNSSPTKNGNSPAKRNSFKWRKNKVKPVDSSIYTLLGVTPKAHLGAGVITQRCTMLMLNEAVRCLDESIIRNPRDGDIGAVFGIGFPPFLGGPFRYLDSLGADKVVQALRLLVQQYGERFEPCQRLVTMAEQQQQFYPVDANIDEVTDVAS
Function: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Catalytic Activity: a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O Sequence Mass (Da): 81350 Sequence Length: 753 Pathway: Lipid metabolism; fatty acid beta-oxidation. Subcellular Location: Cytoplasm
P38135
MHPTGPHLGPDVLFRESNMKVTLTFNEQRRAAYRQQGLWGDASLADYWQQTARAMPDKIAVVDNHGASYTYSALDHAASCLANWMLAKGIESGDRIAFQLPGWCEFTVIYLACLKIGAVSVPLLPSWREAELVWVLNKCQAKMFFAPTLFKQTRPVDLILPLQNQLPQLQQIVGVDKLAPATSSLSLSQIIADNTSLTTAITTHGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQDVFMMPAPLGHATGFLHGVTAPFLIGARSVLLDIFTPDACLALLEQQRCTCMLGATPFVYDLLNVLEKQPADLSALRFFLCGGTTIPKKVARECQQRGIKLLSVYGSTESSPHAVVNLDDPLSRFMHTDGYAAAGVEIKVVDDARKTLPPGCEGEEASRGPNVFMGYFDEPELTARALDEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMSDERLGERSCAYVVLKAPHHSLSLEEVVAFFSRKRVAKYKYPEHIVVIEKLPRTTSGKIQKFLLRKDIMRRLTQDVCEEIE
Function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6:0, C8:0 and C12:0 fatty acids, while has a low activity on C14-C18 chain length fatty acids . Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor . Can functionally replace FadD under anaerobic conditions . Catalytic Activity: ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA Location Topology: Peripheral membrane protein Sequence Mass (Da): 62759 Sequence Length: 566 Pathway: Lipid metabolism; fatty acid beta-oxidation. Subcellular Location: Cell membrane EC: 6.2.1.-
B4YQU1
MASATPAMSENAVLRHKAASTTGIDYESSAAVSPAESPRTSASSTSLSSLSSLDANEKKDEYAGLLDTYGNAFTPPDFSIKDIRAAIPKHCYERSTIKSYAYVLRDLLCLSTTFYLFHNFVTPENIPSNPLRFVLWSIYTVLQGLFATGLWVIGHECGHCAFSPSPFISDLTGWVIHSALLVPYFSWKFSHSAHHKGIGNMERDMVFLPRTREQQATRLGRAVEELGDLCEETPIYTALHLVGKQLIGWPSYLMTNATGHNFHERQREGRGKGKKNGFGGGVNHFDPRSPIFEARQAKYIVLSDIGLGLAIAALVYLGNRFGWANMAVWYFLPYLWVNHWLVAITFLQHTDPTLPHYNREEWNFVRGGACTIDRDLGFIGRHLFHGIADTHVVHHYVSRIPFYNADEASEAIKPIMGKHYRSDTAHGPVGFLHALWKTARWCQWVEPSADAQGAGKGILFYRNRNKLGTKPISMKTQ
Function: Oleate hydroxylase involved in the biosynthesis of ricinoleate . Exhibits delta(12) hydroxylase activity on 16C and 18C monounsaturated fatty acids (e.g. oleic and palmitoleic acids), and, to a lower extent, gamma(3) hydroxylase activity on ricinoleic acid . It uses cytochrome b5 as an electron donor. May act on both oleic acid (18:1(9cis)) and eicosenoic acid (20:1(11cis)) (By similarity). Catalytic Activity: (9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O Location Topology: Multi-pass membrane protein Sequence Mass (Da): 53452 Sequence Length: 477 Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding. Pathway: Lipid metabolism; monounsaturated fatty acid biosynthesis. Subcellular Location: Microsome membrane EC: 1.14.-.-
Q05AM4
MGLTLGERVQHCLLVLVSGLFLALFRLLSPGTKRPKHLPPITNPLLTLSAVQLAEKIRRGEVSSVEVVQAYIDRIQEVNPLLNALIKDRFSAALLEAARADKLIKEENGGEEVLRNQFPLLGVPMSVKESFGLQGMPNSGGLKSRGKVLASVDAPPVALLKRAGAIPLGVTNTSELCMWMESNNHLYGITSNPYNLERICGGSSGGEGSIIGGGASVFGIGSDIGGSIRMPCFFNGIFGHKPSRGVVSNDNQFPRCSGLQNEYTGSGPMCRYAEDLLPLLKIMAGPTADKLTLSKAVDLKKLRFFTIVDDGGSPLTSPVDRQLVEVQKRVAARLEADLGVTVQEVNFPQLKYSYQIWDTFLALPDKDGKPPEAFVELMADGGSVWPVWELIKRIFGRSEHTVAAIGLALMESSHSSKSSEFILKQKEDLQREMEDLLGTDGVLLYPSHPLLAPKHHHPLFMPFNFSYTGILNILGLPVTQCPLGLSKERLPLGVQVVAGLCQDHLTLAMALYLEKAFGGWVDPGVV
Catalytic Activity: H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine Location Topology: Single-pass membrane protein Sequence Mass (Da): 57026 Sequence Length: 526 Subcellular Location: Membrane EC: 3.5.1.99
Q9SUC5
MVAERYTVDLNKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFESDFWEFLTRTVWWAIPTIWLPVVCYVLSISASKGLTFPQIGLIVAFGVLTWTLLEYTLHRFLFHIQTKSYWANTAHYLLHGCHHKHPQDGLRLVFPPTATAILLVPLWKLLHLLATPATAPAILGGILFGYVMYDITHYYLHHGQPKEPTFKHLKKYHLNHHFRIQDKGYGITSSLWDKVFGTLPGIKAAAKKS
Cofactor: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center. Function: Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of the long-chain fatty acid (LCFA) palmitic acid. Probably involved in the resistance response to oxidative stress. Catalytic Activity: an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27311 Sequence Length: 237 Subcellular Location: Endoplasmic reticulum membrane EC: 1.14.18.7
Q93ZE5
MATSMIQRMFKQGTKIVCVGRNYAAHAKELGNAVPKEPVIFLKPTSSYLENGGTIEIPHPLDSLHHEVELALVIGQKARDVPESIAMDYIGGYAVALDMTARELQASAKASGLPWTVAKGQDTFTPISSVLPKAMVRDPDNLELWLKVDGETRQKGLTKDMIFKVPYLISYISSIMTLYEGDVILTGTPEGVGPVKIGQKITAGITGLSEVQFDVERRVKPLS
Function: Probable acylpyruvase. Binds copper in vitro. Catalytic Activity: a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate Sequence Mass (Da): 24283 Sequence Length: 223 Subcellular Location: Mitochondrion EC: 3.7.1.5
P15278
MSRIVFICLAAILTDALTWAQVNVEPNTALLNEGDRTELLCRYGRSINYCRIEIPGEQKVLNLSPEWSKTPGFTYFGAGLTAGQCGVSIERVKASNNGQVKCSLGVEGEELSGTIDLVVALRPQQPIIELLSRPNREGYFNEGTEFRARCSVRDGRPPANISWYIDNMPANKRTTPLEVMSSTNDNVELSTSVQEIQWHLSPEDSNRKLVCRSHHQTDRESVPPQEAAYIINVRYAPVHQPDAAVYGLYLEHTAIVNITIRASPQPKIEWTIDGAIVGQGRTDGRYSAYEPQYLGNDEYNVTLAIAGLTLEDTTKIYNLRASNELGLTDYQVRISSSSKPPSSSLDVAAIVGIVVAVAVLVLVVLLIVFARATGRWCFGGKSIKTPTNETSDTESADIKATSTATATTTMGGVGVSAEEEETVNEQESPQEQQQQQQKKAKRLPAFAAAILRRFNEKDSRKYKDNQESLNIVEGSVQEIPATNNAIDGNDNEPKAIVWQSTSPVWTFK
Function: Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 55884 Sequence Length: 508 Subcellular Location: Membrane
P46000
MNKYPPLLTMLIIGIGSNAVAGDYFDPSLLATDIGNNDKLDLSLFSHPGGGVKGEREVSVYINDFFYKNVTLDFENGISGALEPIFPSGFFDNILASPYRSIKEKELISTADFLSLVPYGMVRFDQAIARVDISIPQAYLGRDAQMKSAPESWNQGVPALLIDYRLSGSKNKYNYGSSQNFYANAFLGFNLMGWRLRTTTNYMSYNSKDLYNKGERQGSFNFYNTYLEKDIGYLRSTLRLGELSTRGMILESFNFKGGKIYSNDEMLNDRLRSYTPTVRGIASSQAVVTIKQGGVVILQKNVPPGPFEINDFSLSGYSGDLYVNIKEADGSEHSFIQPFSTLPEMKREGVSGYEISLGHYNNSGATQYYNESPFLYASWSRGYRNGMTLYSETIQSRKYQLLGVGSTLSLGDFGAVSGDASLSRANKYDKIHSGQSYGLKYSKNKVDTGTTVTLATYRYSTKDFYSFNDFVSKNDSVQYVWDNRLKNRITLSLNQSLDDYGSLSLIASQQNYWTSDYVSRSFSLSHSFGWNDIFFSTSFSLDQKEGDNALRNNNKVFGFYSSIPLSKLIGKNESTYSTLSYNVTKINNQVRNTATLAGKVPGSMAQYRFSSGWANTEQSSNKALSVNWDGDLLDGSLGYTSSGKNRITDYSLSGSAILYPWRLAIGSDSVINGAAVVETEFISGIKVRQGGETSLLGTAIVTSMQPYTENRIDLDTQNIPDDLFISNASKKIVPEKGAVVPVKYNLFKGKQIVFSLKRYDGTPLPFGSVVSLVGSDSEITGIIDDAGRVYLAGIPSKGILHGAWGYNKSCEVSFNLNGKPSNNSNEIIEYEGVCK
Function: Involved in the export and assembly of the 987P fimbriae subunits across the outer membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 92354 Sequence Length: 835 Subcellular Location: Cell outer membrane
Q8JIT7
MSFGLHPWDVAFRPSPPHNLEKKVVPPGADREKSLPSPKEDSDGAREPDSTVDLRKKNKKKKNYQRYAKPPYSYLAMISLVIQNSPEKRLKLSQILQDISSLFPFFKGNYQGWKDSIRHNLSSNDCFRKVLKDPLKPQAKGNYWTVDVTRIPPDALKLQNTAVTRQDLFPLDLAPYILHGQPYRSLERLSANHTRGRTTPRMEPEVQIPVSDPAVSFPMILWNLPTSYSKCVAPNVVAPPSIHPLLLYSNFPSISIYNYLPPPYGSPVYSDRRDLLASGLHPQIPLTPKPPELKNAPSDFPPNKTVFDIPVYTGHPGFLASQSLFSPHLPTATPPLVGYRPSGL
Function: Transcriptional activator. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 2 (ARF2), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much higher affinity than foxh1/fast-1. Acts with foxh1/fast-1 to control the convergent extension movements of gastrulation. Sequence Mass (Da): 38658 Sequence Length: 344 Domain: The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex. Subcellular Location: Nucleus
Q14296
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG
Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. PTM: Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. Catalytic Activity: ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] Sequence Mass (Da): 61104 Sequence Length: 549 Domain: The RAP domain is essential for RNA-binding. Subcellular Location: Mitochondrion matrix EC: 2.7.11.1
P08757
MGLRPDGIIGHSLGEVARAYYNGRISQEEAILSAY
Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Catalytic Activity: acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) Sequence Mass (Da): 3808 Sequence Length: 35 Subcellular Location: Cytoplasm EC: 2.3.1.85
P07855
AEGEGQRDLLKAVAHILGIRDLAGINLDSSLADLGLDSLMGVEVRQTLEREHDLVLSMREVRQL
Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Catalytic Activity: acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) Sequence Mass (Da): 7037 Sequence Length: 64 Subcellular Location: Cytoplasm EC: 2.3.1.85
Q9FZ32
MALYCRDTLIIIFQKLTVADLARASCVCKVWNSVATEDDLVVSAFTAPWRIKELVGRPASVSFWRDNGIWKFAISHRICRGDSVTSLAVKYAVQVMDIKRLNNMMSDHGIYSRDRLLIPISNPEILANTTCYVELDKYAKREVAVLYLEGAPKREQPVPGTNQQSNLSADGKRRLIESLRRSMQVDDGTALYYLAIAEGDPRSALSEFSADLRWERQAGLN
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Sequence Mass (Da): 24904 Sequence Length: 221 Domain: The F-box is necessary for the interaction with ASK proteins. Pathway: Protein modification; protein ubiquitination.
B4RGP0
MAEAILAVRGGLGAKSRLAAVFSDAERAALVEAMLLDMLDALAGAGAGAVRRVWVVTPTERLERLAAAAGARVIREPRPAGLNAAFRCGLAAAAEEAPYADIVLLPGDLPTLRAQDVDAALLLLRTHDLVLALASRDGGTGLLAVRAGVPFTPQFGAQSCARHRRQARARGLSCALVEAGSLALDLDRPEDAVEVARGPCGRRTAEVLSDLKSRWRAQ
Function: Guanylyltransferase that catalyzes the activation of (2R)-3-phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP. It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420. Catalytic Activity: (2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate Sequence Mass (Da): 22786 Sequence Length: 218 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.106
A5USE3
MVIHAIVPVKELHRAKQRLARVLDAHERRALSLAMLNDVLVALSYSPVSRIIVIGRDVETGHTARAHGAAFVIDQSAALNDALHQAAADIPDHAAALVAPSDLPLLGAEDVIALTCISGDKPGVAIAPAHDGGTNLLLVSPVVGWTFLFGPDSLTHHIAAARQRHLPVHLLRLPHLERDIDDIDDLIWLAQQPGDTSAQRLARMFLERKGAQLWQSSDMPPH
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 23996 Sequence Length: 222 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
Q1AXF2
MSVFAVVPVKELRGAKSRLGAVLDPVGRAGLTLHMLRRVVPALRGAGLRRVLVVSPDPAVLEEARLLGAAGLRQEGFGLNAALEEGRRRALEEGAGALLALPADLPLIEPADVAALLEVAGEGPCAVISPDDARSGTNALLLRPPGALPFSFGPGSFGVHLQAALRRGVRVRVCERPNVAFDLDSPEDLARLEASGGVQYRPRRA
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 21464 Sequence Length: 205 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
D1BJD0
MSAEQQAVVSAEQQAVVSAEQPAVVSADQPAVTWTVVVPVKVTSQAKTRLAGDLSPTQRVELVRAMVVDTVAAARATPTVDRVVVVTDDPDVVADLSADEPAGTDAERRADPSAENRASTSAQHPCLRAHLDVVPEPSPAAGLNAAIRAGVASARSGGGLAAVSVAVLLGDLPALRPGDLGAALEAASAHHRAVVTDADGSGTTLLTARSGVELYPAFGPGSAAEHAARGHVVLDVADVPAVSGLRQDVDLARDLAAVAALGPGPRTTEVLDRWARLGEGSSAA
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 28596 Sequence Length: 284 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
D1C883
MTTIAVVPVQRLSTAKSRLAARLAPDERRTLVLSLLDHVLTALNAARQVDAVILVSPDPEVLEHAARRGAIALLQPGVGLNEGLRLGRDEALRRGADTLLIVLADLPWITADEIDALVAALPERGIALAPDRHDHGTNAAALRPPDAIEPAFGAGSFARHQAQARSRGLPLRELRVQGLAFDIDTPADLEELAGHAPVGASSDESGT
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 21837 Sequence Length: 207 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
Q9ZBS2
MQWTLVVPVKALARAKSRLSDTADDGLRPGLALAFAQDTVAAALACPAVADVAVVTDDARAGRELAALGAGVVADEPGGGLNAALAHGAAVVRAARPESPVAALNADLPALRPAELARVLAAATQFPRAFLPDAAGIGTTLLTVAPGQELAPAFGADSRARHRASGAVELRLDAVDSVRQDVDTGGDLRSALALGVGPRTAAVAARLLIAGQ
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 21151 Sequence Length: 212 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
D2AVM1
MLKAMPASESSGWTLVVPVKTLVAAKTRLSEAAGPHRAALAVAIACDTVEAALSCVIVARIVVVTGDPLAAEALGGVGAHVVGDPEAGLNAALRRGAQEAVRLAPGDAVGALQADLPALRPAELALVLTAAAEFEQAFLPDAADVGTTFYGVRPGVPFTPGFGGESRDRHLRRGAKEICLDGIDSVRRDVDTPDDLRAALALGLGPRTLAMVERIRGGFPSP
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 22725 Sequence Length: 222 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
C9Z3U4
MQWTLVVPVKPLARAKSRLSDTAADAVRPGLALAFAQDTVAAALAATAVRGVVVVTDDPLAARELTALGARAVPEDPGGGPGDGLNAALRHGAALVRDVRPQSPVAALNADLPALRPGELTRVLGAAAAFPRAFLADAAGTGTTLLAAAPGHGLSPAFGPGSRTRHRRSGAVELDLTAVDSVRQDVDTGDDLRAALGLGVGPRTAAAAARLLIPGQ
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 21607 Sequence Length: 216 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
D1AB53
MAVETSHDAELTWSLVLPVKPLARAKTRMAEAAGPLRQALALAVAADTVAAALRCAAVAEVIVVTDDPLAAAELSALGARVVPDEPDCGLNPALAHGAALARAARPRAGVGAMSADLPALRPAELGRALAAAAGFAESFVADAQGVGTTLYAVRPGVPFSPAFGPGSRARHAAQGARELAIEGLDSLRRDVDTPGDLRAALALGTGPRTAALAARMPAFSPGAETSRG
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 22845 Sequence Length: 228 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
B9L4T8
MQVLAVVPVQRLEQAKSRLAPALEPAARQALVRELAERTIRILRSVPAVAVIGLLTPDPSLASLASRWGVRTLRDAAHGLNDAVRLAQAEACRLHLPALLIVLGDLPLLDPHAIRHALALLESPGVVLAPDRHGTGTNLLALAPPDVIAPAFGPFSRWRHRRAAAGARCTIRELWSRALVLDLDTPEDLALVHRVREGER
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 21668 Sequence Length: 200 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
D1CDA4
MSAMNIAVLVPVKKLDKAKMRMADTLDRSQRRQLMMVTLRRVLSALQKAQIGDVYLVASDPQVKNIACDLCVKFIPDQGDELNPSLELARGELCQNYDALLVVFGDLPMISDKDIKTIVRLGSSKPSCVIAPDKRNVGTNVLFLHPPYLLPFTFGGNSYERFRSNCEKLGVQFLVYQSQNTALDLDYPQDILDLAALRGHKISGLEEILDPGVLAQISQVTSMSGAKMGA
Function: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Catalytic Activity: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine Sequence Mass (Da): 25358 Sequence Length: 230 Pathway: Cofactor biosynthesis; coenzyme F420 biosynthesis. EC: 2.7.7.105
O55058
MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDEQESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKVGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCFCPVSNPLCREQPSSIVHRYMSITSERSVPADVFQIQATSVYPGAYNAFQIRAGNTQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
Function: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. PTM: N-glycosylated; contains mostly complex-type glycans. Not O-glycosylated. Sequence Mass (Da): 49432 Sequence Length: 443 Subcellular Location: Secreted
O95967
MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
Function: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta . In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction . Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling . PTM: N-glycosylated; contains mostly complex-type glycans . Not O-glycosylated . Sequence Mass (Da): 49405 Sequence Length: 443 Subcellular Location: Secreted
Q9WVJ9
MLPFASCLPGSLLLWAFLLLLLGAASPQDPEEPDSYTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISDLHGEGPPPPAAHAQQPNPCPQGYEPDEQESCVDVDECTQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSITSERSVPADVFQIQATSVYPGAYNAFQIRSGNTQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
Function: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta . In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin . Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction . Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling . PTM: N-glycosylated; contains mostly complex-type glycans. Not O-glycosylated. Sequence Mass (Da): 49425 Sequence Length: 443 Subcellular Location: Secreted
Q9UBX5
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
Function: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN . Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling . May act as an adapter that mediates the interaction between FBN1 and ELN . PTM: N-glycosylated. Sequence Mass (Da): 50180 Sequence Length: 448 Subcellular Location: Secreted
Q53RD9
MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKSRLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTAAPEGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDRSFQANHVSKVTIFVSPYDF
Function: An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. PTM: N-glycosylated. Sequence Mass (Da): 47376 Sequence Length: 439 Subcellular Location: Secreted
Q501P1
MGPGSQRALFLLLLLLASPGARAFQSCLNKQQLLTTIRQLQQLLKGQETRFTEGIRNMKSRLAALQNTVNKMTPDAPPVSCPALEAPPDGKKFGSKYLVDHEVYFTCNPGFQLVGPSSVVCLANGSWTGEQPRCRDISECSSQPCHNGGTCVEGINHYRCICPPGKTGNRCQHQTQAAAPDGGEAGDPAFSRAPRCAQVEREQHCSCEAGFHLSSTTGGHSVCQDVNECEIYGQKGRPRLCMHACVNTPGSYRCTCPSGYRILADGKSCEDVDECAGPQHMCPRGTTCINTGGGFQCVNPECPEGSGNISYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSKLKTPITLFRMATASIPGHPGPNSLRFGIVGGNSRGHFVMQRSDRQTGELILTQTLEGPQTLEVDVDMSEYLERSFQANHVSKVTIFVSRYDF
Function: An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. PTM: N-glycosylated. Sequence Mass (Da): 47927 Sequence Length: 440 Subcellular Location: Secreted
Q96LA6
MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGARSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSPTPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANITDVDYEDAM
Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. PTM: Phosphorylated on tyrosines upon activation. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 46936 Sequence Length: 429 Subcellular Location: Cell membrane
Q8R4Y0
MLPWLLLLICALPCEPAGISDVSLKTRPPGGWVMEGDKLVLICSVDRVTGNITYFWYRGALGFQLETKTQPSLTAEFEISDMKQSDADQYYCAANDGHDPIASELVSIHVRVPVSRPVLTFGDSGTQAVLGDLVELHCKALRGSPPIFYQFYHESIILGNSSAPSGGGASFNFSLTAEHSGNFSCEASNGQGAQRSEVVALNLTGLSLVPTENGISHLSLGLTGWLLGCLSPITMALIFCYWLKRKIGRQSEDPVRSPPQTVLQGSTYPKSPDSRQPEPLYENVNVVSGNEVYSLVYHTPQVLEPAAAQHVRTHGVSESFQVSSGLYSKPRINIAHMDYEDAM
Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation (By similarity). PTM: Phosphorylated on tyrosines upon activation. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 37277 Sequence Length: 343 Subcellular Location: Cell membrane
Q96LA5
MLLWSLLVIFDAVTEQADSLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPRGASRPNPQEFTYSSPTPDMEELQPVYVNVGSVDVDVVYSQVWSMQQPESSANIRTLLENKDSQVIYSSVKKS
Function: May have an regulatory role in normal and neoplastic B cell development. PTM: Isoform 2 is N- and O-glycosylated, and phosphorylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 55542 Sequence Length: 508 Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6. Subcellular Location: Cell membrane
Q96P31
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH
Function: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells . Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling . Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells . Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion . Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion . PTM: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 80856 Sequence Length: 734 Subcellular Location: Cell membrane
Q96PJ5
MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHRHYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSSDSLILQAPYSVFEGDTLVLRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSNFKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVILSDWSTYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCTADNSYGPVQSMVLNVTVRETPGNRDGLVAAGATGGLLSALLLAVALLFHCWRRRKSGVGFLGDETRLPPAPGPGESSHSICPAQVELQSLYVDVHPKKGDLVYSEIQTTQLGEEEEANTSRTLLEDKDVSVVYSEVKTQHPDNSAGKISSKDEES
Function: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. PTM: Phosphorylated on cytoplasmic tyrosines upon activation. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 57224 Sequence Length: 515 Subcellular Location: Cell membrane
Q96RD9
MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVASTPVSGSLFLASSAPHR
Function: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 106437 Sequence Length: 977 Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). Subcellular Location: Cell membrane
Q68SN8
MSGSFSPCVVFTQMWLTLLVVTPVNGQHEAAQQSVVSLQPPWTTFFRGEVVTLTCYRFGFSVPQKTKWYQKRKTVKQTPGALVIKAHTLKVHESGEYWCQADSLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHPQSSEFYIHRANLKDNGQYKCTSKKKWSFGSLYTSNTVVVQVQELFPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFHIPAIWTEESKRYQCKAETVNSQVSKQSTAFIIPVQRASARFQTHIIPASKLVFEGQLLLLNCSVKGVPGPLKFSWYKKDMLNKETKILKSSNAEFKISQVNISDAGEYYCEANNSRRSFVSRAFPITIKVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENVSLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTKNRSVPMAAGITVGLLIMAVGVFLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYYNVPACIELQPVYSNEPEENVIYTEVRRTQPRQKHADQESESPRSRCQMAEKK
Function: May play a role in fertilization. PTM: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 66779 Sequence Length: 596 Subcellular Location: Cell membrane
Q6DN72
MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC
Function: Acts as a MHC class II receptor . When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells . Does not act as an Fc receptor . PTM: Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 47748 Sequence Length: 434 Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding. Subcellular Location: Cell membrane
A1YIY0
MLLWMVLLLCESMAEAQELFPNPELTEFTNSETMDVILKCTIKVDPKNPTLQLFYTFYKNNHVIQDRSPHSVFSAEAKEENSGLYQCMVDTEDGLIQKKSGYLDIQFWTPVSHPVLTLQHEATNLAVGDKVEFLCEAHQGSLPIFYSFYINGEILGKPLAPSGRAASLLASVKAEWSTKNYSCEAKNNISREISELKKFPLVVSGTAWIKSNMLPIWLPASLLGGMVIAAVVLMYFFKPCKKHARPETPTLKEPDSFLYVSVDNQRYK
Function: Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 30237 Sequence Length: 268 Subcellular Location: Cell membrane
A0A2P1BT06
MGERRFSNQQIDRLLRPKSVAVIGASDRKGALGATLLNNLVQYEFSGDIYPVNPKRDELLGLKVYHEVAELPEGIDCAVLAIPRPFVIDTVRQLAQRGCGAVVIYSAGFSEAGEEGMKDQLELAAIAAEYGMVIEGPNCLGCTNYVERVPLTFVETNMQTPPKGTRAVGIASQSGALAAVLATALHPRGLYVSSSVSTGNEAASGVEDYVEWLVDDEDTHVIAMYVESLRRPKAFIAAARRAHAAGKPIVMLHPGKSNKAQESAATHTGAMAGDYALMKTKLAREGVIFADTLEELADITEIALRCRALPGANMAVLGESGALRGLAFDIAEDIGLDLIHLDDDNSPALRAILPDFVPVSNPTDITALGLSEPEIYTKVLTALLEDERIGSVVASIIQSDPITSGIKFPHIIKVLDGGTFAKPLVFAGVDEGATVPKEYIDGLRKVGIPWFPSTERAYRAIARLADLSKRDLADNSGDPIVVPGLDAVSGVVPEYKAKELLRPLGIAFPPSQFAANAEAAAAAARAIGYPVVMKAQAAALGHKSDAGGVILNLKTDDEVRDAFARIYGNVEAYDRSIALDGVLIEKMGKMGTEMIVGAKNDPQWGPVVLAGFGGVTAEILKDVKLFTPEMDAAAVQRGLLELKQAPILKGYRGAPALDVAALAELIVQIGRVMAGNPSIREIDLNPVIIHPAGEGVAALDALMLVER
Function: Catalyzes the formation of feruloyl-CoA, ADP and phosphate from ferulate, CoA and ATP. Catalytic Activity: (E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate Sequence Mass (Da): 74923 Sequence Length: 707 EC: 6.2.1.34
Q55DR6
MSSLSTKTDLLGDPDFIRLQSVEVDGSEVIPGETRPRRNTKFPKLTNSPDGKTFTLYDVYRINKDSDSNFLGIRELLADGKRGDYKWISYKQACIRANNIGSALVQLGLNKGDRIGIFSINRPEWVLSDMAAMNHSLVPVALYATLGANAIEYVVNHSEISVLLCEGKNVEKILSMPGTTIKTIVSYDPLPQATLDKFKDNENVKLYLLSDFEKLGEQNPAQHEVPSPEDLCTLLYTSGSTGNPKGVMLTHTNMVSEVAGANFSPAGVIPEDVHMSYLPLAHSFERAVVSLMCYVGGQIGFFSGLIPELFNDIQVLRPTFLCGAPRVWQRLHDKLWFTVNNDSWLKKFLFNWGLNSKQSALRLGSTTPIWDKLVFSKTKDRLGGRVKFILSGSAPLDPKLAEFLRACFCCPVVSGYGLSENVGGASVAYPEDNNVGHVGPPLSACEMKLIDVPEMNYFSTDKPCPRGEVCIRGFNVFKGYFKDPEKTKEDLKEDGWFHTGDIGRWNENGTLSIIDRKKNIFKLSQGEYVAAEYLESVFVRSPFASQVFVYGDSLNSFLVGVVVPDFEVVQKLFASKYPELDVSNHATLAKSKELYKEILSSFDACAAEAKLHGFEKLKHIYVEHEPFTEENNLLTPSFKPKRPQLKERYQTIIDTLYAEYKRDHPDV
Function: Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm. Catalytic Activity: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate Location Topology: Peripheral membrane protein Sequence Mass (Da): 74609 Sequence Length: 667 Subcellular Location: Endosome membrane EC: 6.2.1.3
Q1ZXQ4
MINNWLAVGLLVVSGILAFNWKRKHPYGQTVEIGEKPENGGRIRRNSACADHLISFLEDDEIYTLYDSLVKSCKKYGERKCFGERKKDSNGNLGKFEWISYNTYLERCEYIQQGLCELGLKPKSKVGIFSKNRLEWLIVHSASFIQSYCVVSFYETLGVESLSYVTEHAEIGLAFCSAETLQKTLDIAKGVKVLKTIICFDSIDKEHYNIAKELGVTLYTYDEIMKKGKEANGKHKHTPPTPDTLSTIMYTSGTTGPPKGVMITHKNLTSVVCAVSDFIKVYDTDVHYSYLPYAHVLERVVILAAFHFGAAIGIFSGDISNILVEVKLLSPTLFIGVPRVFERIKTNVFKEISKKPALLRTLFNGAYNLKYLSIQHGFKLPIIEKVLDLVFFSKIKQALGGKVRVILSGSAPLSFDTEVFLRVVMCCCVLQGYGASEGCGGDACKRLDDESVGTIGPPFASNEIKLVDVPELGYDSNGEVQTGEVCLRGPSISSGYYKDEEKTREEFKDGWFHTGDIGRWNRDGSLSIVDRKKNIFKLSQGEYVAVEKIETIVVKSEYVEQVCIYGDSQKSCVIAIIHPHPESCSEWAGSKKTDKDIKEICKNQDFIKVVLDDIIKNCKKSGLHGFEIPKAIHLTPEAFSDQNNLLTPSFKLKRHEIKKYFEDEIKKLYSKLD
Function: Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. Catalytic Activity: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate Sequence Mass (Da): 75581 Sequence Length: 673 Subcellular Location: Endoplasmic reticulum EC: 6.2.1.3
Q84JK2
MLSSAKHQRNHRLSATNKNQTLTKVSSISSSSPSSSSSSSSTSSSSPLPSQDSQAQKRSLVTMEEVWNDINLASIHHLNRHSPHPQHNHEPRFRGQNHHNQNPNSIFQDFLKGSLNQEPAPTSQTTGSAPNGDSTTVTVLYSSPFPPPATVLSLNSGAGFEFLDNQDPLVTSNSNLHTHHHLSNAHAFNTSFEALVPSSSFGKKRGQDSNEGSGNRRHKRMIKNRESAARSRARKQAYTNELELEVAHLQAENARLKRQQDQLKMAAAIQQPKKNTLQRSSTAPF
Function: Transcription factor required for the transition to flowering promoted by FT. PTM: Phosphorylated at Thr-282 in a calcium-dependent manner by CPK6 and CPK33. Sequence Mass (Da): 31377 Sequence Length: 285 Subcellular Location: Nucleus
Q940E8
MLTATPLPHQLLATFLLVLASATQPAVPASTDRAALLAFRASLSPPSRAALSSWSGPLSPSWLGVSLHPATAPAPSVTTPSVAELSLRGLNLTGVIPAAPLALLRRLRTLDLSANALSGELPCSLPRSLLALDLSRNALSGAVPTCLPSSLPALRTLNLSANFLRLPLSPRLSFPARLAALDLSRNAISGAVPPRIVADPDNSALLLLDLSHNRFSGEIPAGIAAVRSLQGLFLADNQLSGDIPPGIGNLTYLQVLDLSNNRLSGSVPAGLAGCFQLLYLQLGGNQLSGALRPELDALASLKVLDLSNNKISGEIPLPLAGCRSLEVVDLSGNEISGELSSAVAKWLSLKFLSLAGNQLSGHLPDWMFSFPLLQWLDLSSNKFVGFIPDGGFNVSEVLNGGGGQGTPSESVLPPQLFVSASVDTVSWQLDLGYDVQATTGIDLSGNELCGEIPEGLVDMKGLEYLNLSCNYLAGQIPAGLGGMGRLHTLDFSHNGLSGEVPPGIAAMTVLEVLNLSYNSLSGPLPTTKFPGALAGNPGICSGKGCSENARTPEGKMEGSNHRGWLGGWHGENGWVSLGAFCISTMTSFYVSLATLLCSSNARNFVFRPVRVEY
Function: Receptor-like protein that regulates shoot meristem proliferation. Based on additive and synergistic phenotypes of double mutants, it is probable that unlike CLV1 and CLV2 in A.thaliana, FAE2 and TD1 do not function exclusively in a single pathway. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 63951 Sequence Length: 613 Subcellular Location: Cell membrane
P80668
MTEPHVAVLSQVQQFLDRQHGLYIDGRPGPAQSEKRLAIFDPATGQEIASTADANEADVDNAVMSAWRAFVSRRWAGRLPAERERILLRFADLVEQHSEELAQLETLEQGKSIAISRAFEVGCTLNWMRYTAGLTTKIAGKTLDLSIPLPQGARYQAWTRKEPVGVVAGIVPWNFPLMIGMWKVMPALAAGCSIVIKPSETTPLTMLRVAELASEAGIPDGVFNVVTGSGAVCGAALTSHPHVAKISFTGSTATGKGIARTAADHLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYIEAPLFDTLVSGFEQAVKSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRGSNGPAGEGYYVAPTLVVNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTASVWTQNLSQALEYSDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKSVCVRY
Function: Acts almost equally well on phenylacetaldehyde, 4-hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Catalytic Activity: 2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH Sequence Mass (Da): 53699 Sequence Length: 499 Pathway: Amino-acid degradation; L-phenylalanine degradation; phenylacetate from L-phenylalanine: step 3/3. EC: 1.2.1.39
P13036
MTPLRVFRKTTPLVNTIRLSLLPLAGLSFSAFAAQVNIAPGSLDKALNQYAAHSGFTLSVDASLTRGKQSNGLHGDYDVESGLQQLLDGSGLQVKPLGNNSWTLEPAPAPKEDALTVVGDWLGDARENDVFEHAGARDVIRREDFAKTGATTMREVLNRIPGVSAPENNGTGSHDLAMNFGIRGLNPRLASRSTVLMDGIPVPFAPYGQPQLSLAPVSLGNMDAIDVVRGGGAVRYGPQSVGGVVNFVTRAIPQDFGIEAGVEGQLSPTSSQNNPKETHNLMVGGTADNGFGTALLYSGTRGSDWREHSATRIDDLMLKSKYAPDEVHTFNSLLQYYDGEADMPGGLSRADYDADRWQSTRPYDRFWGRRKLASLGYQFQPDSQHKFNIQGFYTQTLRSGYLEQGKRITLSPRNYWVRGIEPRYSQIFMIGPSAHEVGVGYRYLNESTHEMRYYTATSSGQLPSGSSPYDRDTRSGTEAHAWYLDDKIDIGNWTITPGMRFEHIESYQNNAITGTHEEVSYNAPLPALNVLYHLTDSWNLYANTEGSFGTVQYSQIGKAVQSGNVEPEKARTWELGTRYDDGALTAEMGLFLINFNNQYDSNQTNDTVTARGKTRHTGLETQARYDLGTLTPTLDNVSIYASYAYVNAEIREKGDTYGNLVPFSPKHKGTLGVDYKPGNWTFNLNSDFQSSQFADNANTVKESADGSTGRIPGFMLWGARVAYDFGPQMADLNLAFGVKNIFDQDYFIRSYDDNNKGIYAGQPRTLYMQGSLKF
Function: FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85322 Sequence Length: 774 Subcellular Location: Cell outer membrane
P15030
MTAIKHPVLLWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVSWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG
Function: Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34893 Sequence Length: 332 Subcellular Location: Cell inner membrane
P15029
MKIALVIFITLALAGCALLSLHMGVIPVPWRALLTDWQAGHEHYYVLMEYRLPRLLLALFVGAALAVAGVLIQGIVRNPLASPDILGVNHAASLASVGALLLMPSLPVMVLPLLAFAGGMAGLILLKMLAKTHQPMKLALTGVALSACWASLTDYLMLSRPQDVNNALLWLTGSLWGRDWSFVKIAIPLMILFLPLSLSFCRDLDLLALGDARATTLGVSVPHTRFWALLLAVAMTSTGVAACGPISFIGLVVPHMMRSITGGRHRRLLPVSALTGALLLVVADLLARIIHPPLELPVGVLTAIIGAPWFVWLLVRMR
Function: Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34131 Sequence Length: 318 Subcellular Location: Cell inner membrane
P15031
MTLRTENLTVSYGTDKVLNDVSLSLPTGKITALIGPNGCGKSTLLNCFSRLLMPQSGTVFLGDNPINMLSSRQLARRLSLLPQHHLTPEGITVQELVSYGRNPWLSLWGRLSAEDNARVNVAMNQTRINHLAVRRLTELSGGQRQRAFLAMVLAQNTPVVLLDEPTTYLDINHQVDLMRLMGELRTQGKTVVAVLHDLNQASRYCDQLVVMANGHVMAQGTPEEVMTPGLLRTVFSVEAEIHPEPVSGRPMCLMR
Function: Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28191 Sequence Length: 255 Subcellular Location: Cell inner membrane
P23485
MNPLLTDSRRQALRSASHWYAVLSGERVSPQQEARWQQWYEQDQDNQWAWQQVENLRNQLGGVPGDVASRALHDTRLTRRHVMKGLLLLLGAGGGWQLWQSETGEGLRADYRTAKGTVSRQQLEDGSLLTLNTQSAADVRFDAHQRTVRLWYGEIAITTAKDALQRPFRVLTRQGQLTALGTEFTVRQQDNFTQLDVQQHAVEVLLASAPAQKRIVNAGESLQFSASEFGAVKPLDDESTSWTKDILSFSDKPLGEVIATLTRYRNGVLRCDPAVAGLRLSGTFPLKNTDAILNVIAQTLPVKIQSITRYWINISPL
Function: Required for transcriptional activation of the fecABCDE operon by sigma factor FecI . Undergoes sequential cleavage to produce an N-terminal cytoplasmic fragment which is released from the membrane and binds to FecI, allowing it to activate transcription of the fecABCDE operon which mediates ferric citrate transport . In the absence of citrate, FecR inactivates FecI . PTM: Sequentially cleaved starting with cleavage immediately after translation to generate CL(a). CL(a) is then cleaved by an unknown protease in the periplasm to yield CL(b). Finally, CL(b) undergoes intramembrane proteolysis by RseP to produce the N-terminal cytoplasmic fragment CL(c) which is released from the membrane and binds to sigma factor FecI, allowing it to activate transcription of the fecABCDE operon. Location Topology: Single-pass membrane protein Sequence Mass (Da): 35532 Sequence Length: 317 Subcellular Location: Cell inner membrane
Q6C116
MGIKGLNKLLMEHCPAALRSSEIKNFGGRKVAIDASMSLYQFVIAVRQADGQQLTNENGETTSHLMGMFYRTLRMVDNGIKPVYVFDGKPPVLKSGELAKRKERREEALKKIEELKQQVEDGEEGEETKEAQEDVTRFEKRTVRVTPEQNDEAKKLLTLMGIPIVEAPCEAEAQCAKLAEAGKVYAAASEDMDTLCFGSPVLLRHLTFSEAKKMPISEINFAKILEGLEMTHAQFIDLCILLGCDYADTIRGVGPQTALKLMKEHGSLEKIVEHIEKNPSGKLKVPENWPYQEVRALLQAPDVLDSSSCDIKWNNPDVEGLVDFLVRDKGFSEDRVRAGAARLMKQVKVKPQARLDGFFKVMPKEGGEKRKADDKKTKGKKPATKKAKK
Cofactor: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding. Function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. PTM: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Sequence Mass (Da): 43446 Sequence Length: 389 Subcellular Location: Nucleus EC: 3.1.-.-
P25621
MMKESKSITQHEVERESVSSKRAIKKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYISGMKEDLKMVGNDLTVSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMYKVTSFKHICAIRFFQALFESCTFSGTHFVLGSWYKEDELPIRSAIFTGSGLVGSMFSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSLVWVLGGENLGFASNSTFALWLQNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRADPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWWSILFFASDMVPKFERGCYALLATAISSGIVSVVIRSLQIKENLSKKQVPYIDANDMPGEDDDDDNQDNENDGDDESMEVELHNEEMAEISNPFR
Function: Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 58256 Sequence Length: 512 Subcellular Location: Cell membrane
Q9GNL3
MFHSLVLMACALAALSVAQGAGSARSKSLPLSLSLSVSVSSSLASASSPGAAADPTAAFTVTATAPTPASAPFAGKQLNRCRQSCYQQLSKDWHYCKDSVDCTNCCQKLVAPFELRILKAQRQESLVLTDIGWDEMIANASRQCLITWEVSGGGLIGNLLTDTARAELSLWPDTVYNIQVKCKHKLTGLMRRSIKLNVDTSQLVGTTTTTTTSKSSIQRQHLEQPVDHTDALEHSQHIRIPRPTDRVYIISALPTPSELGGVVYPAFGALAFFLALLVMFLFLRPQRKRFPLDADSADTATLIGRSSSSSRNSMDASTLHV
Function: Involved in the normal targeting of ventral muscle, muscle 12, by motoneurons. May function as an axon guidance molecule involved in neuromuscular specificity. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 34626 Sequence Length: 321 Subcellular Location: Membrane
Q9R9J2
MNNLAFLFPGQGSQFVGMGKSFWNDFVLAKRLFEEASDAISMDVKKLCFDGDMTELTRTMNAQPAILTVSVIAYQVYMQEIGIKPHFLAGHSLGEYSALVCAGVLSFQEAVKLIRQRGILMQNADPEQLGTMAAITQVYIQPLQDLCTEISTEDFPVGVACMNSDQQHVISGHRQAVEFVIKKAERMGANHTYLNVSAPFHSSMMRSASEQFQTALNQYSFRDAEWPIISNVTAIPYNNGHSVREHLQTHMTMPVRWAESMHYLLLHGVTEVIEMGPKNVLVGLLKKITNHIAAYPLGQTSDLHLLSDSAERNENIVNLRKKQLNKMMIQSIIARNYNKDAKTYSNLTTPLFPQIQLLKERVERKEVELSAEELEHSIHLCQLICEAKQLPTWEQLRILK
Function: Is involved in the mycosubtilin synthetase assembly, by catalyzing the transfer of malonyl groups to a specific acyl-carrier-protein domain on MycA. Catalytic Activity: holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP] Sequence Mass (Da): 45222 Sequence Length: 400 EC: 2.3.1.39
Q5WAF1
MQEKEMFDLTIIGGGPAGLYSTFYAGMRDLKVKLVEYNKELGGKILFYPEKIIWDVGGMPPTTGRTLINQLVEQATTFNPTICLNEHIVRMVREPDNTYTLFNEQGKAHYTRAVMLASGHGIPVMQKLEIEGADRYEVSNLHYTVTQMDIFANKRVLISGGGNAAVDWANELANISKEVVVCHRRDEFGGHEKNVEQMKSVTKIHTPYQIKELHGVGSAIEAVTLAHCDTGEQRQIEVDAVIVNHGMKLDGCFLIEAGLALEEDGFLRVSACMETSQPGIFAAGDVTRHEGKLQLISGAFVEGATAVNGVKQFLDPKADKQAYVSSHNEKFKKKNEQLKQEKQAQLMN
Cofactor: Binds 1 FAD per subunit. Catalytic Activity: H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 38586 Sequence Length: 348 EC: 1.18.1.2
A8FB45
MTEQLELFDVTIIGGGPAGMYTAFYSGMRDLKTKVLEYNESLGGKILLYPEKVIWDVGGLPPTRGEQLIQQLEKQAKTFEPEIALNQKITSFERDEHQNILLTAENGDRHLTKTLILAMGHGIPVQRKLEIEHADRYEVTNLYYTVQELKTFAGKRVVISGGGDSAVDWANALVPIAESVTVVHRRDMFGGHEKNVANMKASCARILTPHELTDLHGQGDKIDAVTIQHLETGEIERIETDAVIVNHGMKGDLSVLSEWGLKQGEWGLIEVNEKMETNLPGVYAVGDLCTHKSKVRLIAGTFVDGVNALNSAKLYIEPEAEKVAYVSSHNERFKEKNKELQTVGAR
Cofactor: Binds 1 FAD per subunit. Catalytic Activity: H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 38418 Sequence Length: 346 EC: 1.18.1.2
O31475
MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIVLTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVISGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMRTNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLVHK
Cofactor: Binds 1 FAD per subunit. Catalytic Activity: H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 36967 Sequence Length: 336 EC: 1.18.1.2
P24134
TXIVIIGGGPGGYEAA
Function: Couples electron transfer from NADH to cytochrome P450(soy) in the presence of ferredoxin. Catalytic Activity: H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 1486 Sequence Length: 16 EC: 1.18.1.3
Q8DUN5
MEEEKLTSEKEIYDITVIGGGPVGLFTAFYAGLRGISVKVIESLSELGGQPAILYPEKVIYDIPAFPAITGADLVDNLIEQLERFKDKTTICLKEEVKTFEKENAIFTITTNKGNHFSKAIIIACGNGAFAPRRLGLDDEERYADHNLFYNVHKLDQFAGKKVVICGGGDSAVDWANALDKIAESVTLVHRRDAFRAHEHSVEVLKTSHVNIMTPYVPLELKGEGDEATSLVIQKVKSEETKELSLDSLIVSFGFSTSNKNLKSWNIDYKRSSINVSPLFETSQTGVFAIGDAAEYEGKIDLIATGFGEAPTAVNQAIKYIYPERDNRVVHSTSLIK
Cofactor: Binds 1 FAD per subunit. Catalytic Activity: H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 37155 Sequence Length: 337 EC: 1.18.1.2
P23877
MIYVSRRLLITCLLLVSACVVAGIWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALSAMVGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLMMLVAVVLTAAATALAGPISFIALVAPHIARRISGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQESRKK
Function: Part of the ABC transporter complex FepBDGC involved in ferric enterobactin uptake . Responsible for the translocation of the substrate across the membrane (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34910 Sequence Length: 330 Subcellular Location: Cell inner membrane
P17007
MAVYKVRLICEEQGLDTTIECPDDEYILDAAEEQGIDLPYSCRAGACSTCAGKVVEGTVDQSDQSFLDDAQLAAGYVLTCVAYPSSDCTVKTHQEESLY
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10726 Sequence Length: 99 Subcellular Location: Plastid
P00239
SYMVTLKTPSGEQKVEVSPDSYILDAAEEAGVDLPYSCRAGSCSSCAGKVESGTVDQSDQSFLDDDQMDSGFVLTCVAYATSDCTIVTHQEENLY
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10162 Sequence Length: 95 Subcellular Location: Plastid
O78510
MATYKVKLSGEGVDKTIDCPDDQYILDAAEEQGIDLPYSCRAGACSTCAGKVAAGSVDQSDQSFLDDSQIGDGFVLTCVAYPTSDCTILTHQEEGLY
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10281 Sequence Length: 97 Subcellular Location: Plastid
D0LZ73
MSSEQLHEPAELLSEETKNMHRALVTLIEELEAVDWYQQRADACSEPGLHDVLIHNKNEEVEHAMMTLEWIRRRSPVFDAHMRTYLFTERPILELEEEDTGSSSSVAASPTSAPSHGSLGIGSLRQEGKED
Function: Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like ferroxidase that converts Fe(2+) to Fe(3+) iron inside the encapsulin nanocompartment . Mineralized Fe(3+) is released to the exterior of the decameric complex for deposition in the encapsulin nanocompartment. In solution the decamer binds 10-15 iron cations; in the encapsulin nanocompartment the decamer can bind up to 48 ions, perhaps via its internal channel, and on its exterior. The cargo-loaded nanocompartment maximally sequesters up to 4150 Fe ions (By similarity). Catalytic Activity: 4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O Sequence Mass (Da): 14799 Sequence Length: 131 Domain: The decamer has negatively charged patches on its exterior, and a negatively charged tunnel at the center, the charges are probably metal-binding sites. Subcellular Location: Encapsulin nanocompartment EC: 1.16.3.1
P00225
AFKVKLLTPDGPKEFECPDDVYILDQAEELGIELPYSCRAGSCSSCAGKLVEGDLDQSDQSFLDDEQIEEGWVLTCAAYPRSDVVIETHKEEELTG
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10588 Sequence Length: 96 Subcellular Location: Plastid
P09735
TFKVTLNTPTGQSVIDVEDDEYILDAAEEAGLSLPYSCRAGACSSCAGKVTAGEVDQSDESFLDDDQMDEGYVLTCIAYPTSDLTIDTHQEEALI
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10174 Sequence Length: 95 Subcellular Location: Plastid
Q8TQQ5
MVWHYTNDVALYCRAFRSMPHCLRERQYFMVKDHDLLLKLTGELVSVNINRYKCGYCGACVGVCPKGALELVETWIEVDESTCIKCGICDRICPVGAIEVMK
Cofactor: Binds 2 [4Fe-4S] clusters. Function: Ferredoxin that is the specific electron donor for the geranylgeranyl reductase GGR involved in the biosynthesis of archaeal membrane lipids. Sequence Mass (Da): 11624 Sequence Length: 102 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism.
P02765
MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV
Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. PTM: Phosphorylated by FAM20C in the extracellular medium. Sequence Mass (Da): 39341 Sequence Length: 367 Subcellular Location: Secreted
P80191
LVLLLSLAQLWSCHLVTAVPLLGYREHNCDDPEAEQVALLAVDHINNHLQQGYKHILNRIDKVKVWPRRPTGEVYELEIDTLETTCHALDPTPLANCSVRQVTQHAVEGDCDFHVLKQDGQFTVLSAKCDSTPDSAEDILKLCPDCPLLTPLNDTRVAQAAEAALTAFNEKNNGAYLQLVEIARAQLVPLPASTYVEFTVAATDCVAKEVTDPAKCNLLADKQYGFCKATVAEKVAREEVEVTCTIFPAQPVVPQPQPGVAGAAAVEPAPAVDPASPVSPPDGQSPSSLVVGPVLVAQAPAPPRAHYDLRQTFAGVPSMESGSGEAFHPGKVPVVVQPSVGAAPGPVITPCPGKVRYFKI
Function: A cell adhesion protein that binds immature cells of the granulocyte lineage. PTM: Phosphorylated by FAM20C in the extracellular medium. Sequence Mass (Da): 38387 Sequence Length: 360 Subcellular Location: Secreted
P24090
MKSLVLLLCFAQLWSCQSAPQGAGLGFRELACDDPETEHVALIAVDYLNKHLLQGFRQILNQIDKVKVWSRRPFGEVYELEIDTLETTCHALDPTPLANCSVRQQAEHAVEGDCDFHILKQDGQFRVLHAQCHSTPDSAEDVRKFCPRCPILIRFNDTNVVHTVKTALAAFNAQNNGTYFKLVEISRAQNVPFPVSTLVEFVIAATDCTGQEVTDPAKCNLLAEKQYGFCKATLIHRLGGEEVSVACKLFQTQPQPANANPAGPAPTVGQAAPVAPPAGPPESVVVGPVAVPLGLPDHRTHHDLRHAFSPVASVESASGEVLHSPKVGQPGDAGAAGPVAPLCPGRVRYFKI
Function: Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells. PTM: Undergoes complex post-translational modification involving N-glycosylation, and addition of fucose and sialic acid residues. Phosphorylation occurs at a serine residue. Sequence Mass (Da): 37982 Sequence Length: 352 Subcellular Location: Secreted
P37237
MGSPRSALSCLLLHLLVLCLQAQVRSAAQKRGPGAGNPADTLGQGHEDRPFGQRSRAGKNFTNPAPNYPEEGSKEQRDSVLPKVTQRHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR
Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis . PTM: The N-terminus is blocked. Sequence Mass (Da): 30420 Sequence Length: 268 Subcellular Location: Secreted
A8MR65
MDDADKSCSPSLDHSDINDPMIVAVESLDTSKKRKLHAEESDLLPLPKHFCSEHQASLVNSSCPSSVIDYAECSYAMENTKTSDEASSSASFTGPSLYMFKDSIYSTGSSSSGYAATSSIEQCFSKVDHKTQEDTQDFTHMEFIYHDSEFAVEDLQEVLNPVESYILSSARWSVSNQDSKEATTKPTIDQEFEQYFSTLMM
Function: Can activate transcription (By similarity). Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes . PHYA-specific signal transducer in response to continuous FR lights. Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions . Contributes to inhibition of hypocotyl elongation in continuous blue light (B) . PTM: Inactivated by rapid reversible PHYA-mediated phosphorylation. Sequence Mass (Da): 22376 Sequence Length: 201 Subcellular Location: Nucleus
P96809
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
Function: Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis . Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity . PTM: Is exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Sequence Mass (Da): 38445 Sequence Length: 360 Pathway: Lipid metabolism; mycolic acid biosynthesis. Subcellular Location: Cell envelope EC: 1.1.98.-
Q988C8
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALPSAGVGTVRFTDDIGDAVSGADLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPITKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQTVATIRDLIRSIGLLPVVVKKDVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDIYKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVAVRRILEGRE
Function: Involved in the degradation of pyridoxine (vitamin B(6)). Catalyzes the oxidation of 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate (FHMPC) by NAD(+) to 5-hydroxy-6-methylpyridine-3,4-dicarboxylate (HMPDC) . Can also catalyze the reduction of FHMPC by NADH to 4-pyridoxic acid . Catalytic Activity: 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH Sequence Mass (Da): 33061 Sequence Length: 309 Pathway: Cofactor degradation; B6 vitamer degradation. EC: 1.2.1.100
P53279
MLSAADNLVRIINAVFLIISIGLISGLIGTQTKHSSRVNFCMFAAVYGLVTDSLYGFLANFWTSLTYPAILLVLDFLNFIFTFVAATALAVGIRCHSCKNKTYLEQNKIIQGSSSRCHQSQAAVAFFYFSCFLFLIKVTVATMGMMQNGGFGSNTGFSRRRARRQMGIPTISQV
Function: Involved in membrane organization. Required for the formation of membrane compartments of CAN1 (MCCs), localization of CAN1 at the MCCs and subsequent invagination of the plasma membrane at the MCCs sites. Involved in eisosome organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 19152 Sequence Length: 174 Subcellular Location: Cell membrane
Q59MV9
MTVEYETKQLTPAQIKIILDTVPILEEAGETLTQKFYQRMIGNYDEVKPFFNTTDQKLLRQPKILAFALLNYAKNIEDLTPLTDFVKQIVVKHIGLQVLPEHYPIVGTCLIQTMVELLPPEIANKDFLEAWTIAYGNLAKLLIDLEAAEYAKQPWRWFKDFKVTRIVQECKDVKSVYFTPVDKDLLPLPKPERGQYLCFRWKLPGEEFEISREYSVSEFPKENEYRISVRHVPGGKISGYIHNNLKVGDILKVAPPAGNFVYDPATDKELIFVAGGIGITPLLSMIERALEEGKNVKLLYSNRSAETRAFGNLFKEYKSKFGDKFQAIEYFSEDNNTDDKIVIDKAFNRKLTTDDLDFIAPEHDVYLVGPREFMKDIKEHLGKKNVPVKLEYFGPYDP
Cofactor: Binds 1 FAD per subunit. Function: Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system. Catalytic Activity: NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate Sequence Mass (Da): 45819 Sequence Length: 398 Domain: Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. Subcellular Location: Cytoplasm EC: 1.14.12.17
Q03331
MSAAKQLFKIVPLTPTEINFLQSLAPVVKEHGVTVTSTMYKYMFQTYPEVRSYFNMTNQKTGRQPKVLAFSLYQYILHLNDLTPISGFVNQIVLKHCGLGIKPDQYPVVGESLVQAFKMVLGEAADEHFVEVFKKAYGNLAQTLIDAEASVYKTLAWEEFKDFRVTKLVKEAEDVTSVYLTPVDGFKLKPIIPGEYISFRWDIHNPDITDIQPREYSISQDVKENEYRISVRDIGIVSDYINKKLQVGDIVPVHAPVGTMKYDSISKKGKVAVLAGGIGITPMIPIIEHALKDGKDVELYYSNRSYQSEPFREFFSNLEKENNGKFKLNNYISAENQKLQVKDLEHINPDEYDVYLLGPVAYMHEFKTYLVGKGVSDLKMEFFGPTDPDC
Cofactor: Binds 1 FAD per subunit. Function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). Catalytic Activity: NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate Sequence Mass (Da): 44363 Sequence Length: 390 Domain: Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. Subcellular Location: Cytoplasm EC: 1.14.12.17
Q9URY5
MSSVEVNRENADVANTNRQANLAEGYEIKELNESQKQYIRSSIPILESSGVNLTKAFYQKMLGNYPEVLPYFNKAHQISLSQPRILAFALLNYAKNIDDLTSLSAFMDQIVVKHVGLQIKAEHYPIVGHCLLSTMQELLPSDVATPAFLEAWTTAYGNLAKILIDSEKKVYQSQPWNGFVEFKVTELINESSDVKSVYLGPKDPAFRISHAHPGQYVSVLWEIPGLSHKTLREYSLSNRVDTCRNQFRISVRRVAGGVVSNFVHDNLKVGDIVGVSPPAGNFVYKRSEENVNRPLLCFAGGIGITPLIPIIETALLDGRKVNFCYSSRNYVSRPFKQWLEQLKLKYKENLKLKEFFSEESSVTKEQIVDEVMTRIINEEDLEKLDLSECDIYMLGPNNYMRFVKQELVKLGVEPNKVQSEFFGPYIP
Cofactor: Binds 1 FAD per subunit. Function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). Catalytic Activity: NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate Sequence Mass (Da): 48459 Sequence Length: 427 Domain: Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. Subcellular Location: Cytoplasm EC: 1.14.12.17
P39676
MLAEKTRSIIKATVPVLEQQGTVITRTFYKNMLTEHTELLNIFNRTNQKVGAQPNALATTVLAAAKNIDDLSVLMDHVKQIGHKHRALQIKPEHYPIVGEYLLKAIKEVLGDAATPEIINAWGEAYQAIADIFITVEKKMYEEALWPGWKPFDITAKEYVASDIVEFTVKPKFGSGIELESLPITPGQYITVNTHPIRQENQYDALRHYSLCSASTKNGLRFAVKMEAARENFPAGLVSEYLHKDAKVGDEIKLSAPAGDFAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQVKCNPNRPIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKEKSPAHADVYTCGSLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV
Cofactor: Binds 1 FAD per subunit. Function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Catalytic Activity: NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate Sequence Mass (Da): 44646 Sequence Length: 399 Domain: Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. Subcellular Location: Cytoplasm EC: 1.14.12.17
A7LXW1
MRNTRYGFLVLLSSLLMLTGCSRRDILDDYPVSGVDIKLDWDGVTDQLPEGVRVIFYPKNGDGRKVDKYLSVRGGEMKVPPGRYSVVVYNYNTESIRIRGEESYETIEAYTGNCNGLGIEGTEKMVWSPDSLYVLNIDELKIEKSEEVLRLDWKLESVVKKYSFAVEAKGLEYVATVVGSIDGLSDCYCIGKGRGVCSSQPIYFEVKKGDNKVTAFFTAFKQVKEMTMPTRMSTSERETSSEKGAIILILKFIKTDNTVQEATIDVTEIIGTLENAGTGEDGKPTPPPEIELPPDDKIEVDKPETPPNPDGGGGMGGNVDGWGPEDNVELPVN
Function: Putative fimbrium anchoring subunit. Location Topology: Lipid-anchor Sequence Mass (Da): 36725 Sequence Length: 333 Subcellular Location: Cell outer membrane
A0PA81
MNDAKKYIVSVLILLVAGMFGGCIKEDYSDCPRPFRLTVRAWDADMQDITETGAVQRVVIFVFDETGRRIDRLMMDAAQVAARKPIPLEYDGPTTVSFVAWANPDDHMLEETANVQNVKDLFFRLSSTDGIAQSPGDLFSGVLTCPIEYGSIEQGTDQTVDIYRRTAQVHIIIRGYQEWLEANGPRQLPDYADILLGETPDTYTGLAELIGNAVQYRPDGQIQNGDFISPIIRVYPTLDTTPLHLKLYAYGQELLNISTGSDGVPFIPVIGKMLNIYIDLRGANLNVLVSVTPWDVVQQYAEY
Function: Anchoring subunit of the major fimbriae. Regulates fimbrial length . These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. Fimbriae of P.gingivalis are major virulence factors (Probable). Location Topology: Lipid-anchor Sequence Mass (Da): 33805 Sequence Length: 303 Subcellular Location: Cell outer membrane
P33410
MKQIPLILAMSLAFAAAAKGESAPDMQAAVNFDSAMLWGGANGADLSRFNYSNALRPGNYIVDIYANNYPLIRQQVRFVAAQTSGQGLKTAPAVACFTYGQLEAMQVRLRALDPALVADLKSSGRCEVLGKLFPDSRESFDFGENRLEVSIPQAYTINRFRRDISPDEWDSGITAFRLGYQYNYADYIGGLRAGRRLDLNLYSGFNFKGWYLRNSSTLGWGQGRFTRRSQRTSLQTDIPSWRARLVFGDVFSSGEYFAPYSMRGMLVGSDTAMLPYSERLYRPTIRGVARTRANVKVYQAGVLVFQDAVPPGPFAIDDYSPASYGGDLRVVVTEANGAVQTFTVPYASAVRLILPGQTQWSFSAGRYRNYRNDGQDRPWVTQLTGRHGVADGVNLYGGLLIAQAYQAGLAGLSWNTPWGAMAADATLSRSQLSTTGNANGSSLRFSYSKTLSGTNTAIRLATLRYSSSGFWNFADAVNAGPVETNGRNGRFGLYSLLGRERPRGDFSVTLSQPLGGYGSLYVSALRRTYWGSSRVDQQTQLGYSTQVGRVGVNLDVSRTENRRSTEHQVMLNLSIPLYGATSSGVVTGSLARTGSAPVQQSVNYSGMSGERDQYTYGLGVQRAGTSAQYALNGSWSGTYGEVSGQLTHGRSYSQYQINGSGGLVAHAGGVTFGQYQAGTIGLIQAEAAAGAKVVNTRNAAVDRSGYGLVSLTPYSLNEVELSPQDLPLDVQLESTVEQVIPRAGAVVALRFPTRHDVAAMLVAEPGSEGALVFGTEVRDGAGKVVGVAGQGASALVRGVSASGTLEVTRADGSICRATYDLKSAGQAVHGLPRIALACAPQGGGERGARAAGQAVAQPSAISISGKDHEPDIR
Function: Probable porin-like protein necessary for the assembly of a pilin-type protein. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 93369 Sequence Length: 873 Subcellular Location: Cell outer membrane
B7YZT2
MEDLLNEVVPQEDLERFEKKYHHELELDGEVTTDTKFEYAFCLVRSRYTNDVRKGIMILEELARTHPDGRRDYIYYLAFGNARIKEYTSGLKYCRAFLDIESNDQVRSLEEYIKKEIDKEVAKGMVVAGGAALVLGGILGLGIAMARNKQKREK
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering . Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission . Location Topology: Single-pass membrane protein Sequence Mass (Da): 17771 Sequence Length: 154 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
Q4IBU4
MVTELPYALDAETPLNPSELNVLKAQYDREGEMVGVQTKFNYAWGLVKSNQRNDQQLGVRLLSDIFRVSPERRRECLYYLALGNYKLGNYGEARRYNDLLLDKEPANLQASNLRSLIDDKVAREGLMGVAILSGVGVAAGVVGAFLLRNARKR
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 17134 Sequence Length: 153 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
Q9Y3D6
MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering . Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission . May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event . Also mediates peroxisomal fission . May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis . Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis . PTM: Ubiquitinated by MARCHF5. Location Topology: Single-pass membrane protein Sequence Mass (Da): 16938 Sequence Length: 152 Domain: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. Subcellular Location: Mitochondrion outer membrane
Q9CQ92
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering . Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission . May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). PTM: Ubiquitinated by MARCHF5. Location Topology: Single-pass membrane protein Sequence Mass (Da): 17009 Sequence Length: 152 Domain: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. Subcellular Location: Mitochondrion outer membrane
Q7S8M1
MTQLPYAVDAETPLNPAELNVLRAQYEKEGEMVGVQTKFNYAWGLVKSNVRADQHLGVMLLSEIFRTSPERRRECLYYLALGNYKLGNYAQARKYNDALLENEPANLQAANLRALIDDKVTKEGLMGVAIISGVAVAAGVIGGVLLRNLGRKR
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 16924 Sequence Length: 153 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
P84817
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering . Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). PTM: Ubiquitinated by MARCHF5. Location Topology: Single-pass membrane protein Sequence Mass (Da): 16995 Sequence Length: 152 Domain: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. Subcellular Location: Mitochondrion outer membrane
Q9USZ8
MTEKHTLRLADPSAIDSIISVDEFLQIKEQYDAEQPLITLQTKFNLAWALVRSDSTQHVQQGLSLFCSIYKDSPERRLECLYYIALSHYKLKQYEESRRYLNMLLSKDPNSPEALKLKNRLYDAVTKEGYIGMVVVAGAVVSVAALVGWASKRLFSKRRP
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 18329 Sequence Length: 160 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
Q4P7J4
MSLPYAADAETSLSPSELQVLKSQYETELASGHVTTQTKFNYAWGLVKSKQRAEMSIGVGLLTEIYRSDPPRRRECLYYLSLGHYKMGNYDEARRFNALLIEREPNNLQAQSLNQLIEKGVAREGYIGMALIGGAAAVASIAIAGLMRRGRR
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 16900 Sequence Length: 152 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
Q6CFJ0
MKKEDYLPNLVDIESPLSDEELYVLSQQYNNEGDFVSVQTRFNYAWGLIKSRKVEDQQLGVQILAQVYKDTPSRRRECLYYLAIGSYKLGEYTDARKYCDLLLQIEPDDPQSAKLRQIIEDKLAKEGMIGIAIVGGVIAVGAAVLGAVLSQKKR
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 17392 Sequence Length: 154 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
P40515
MTKVDFWPTLKDAYEPLYPQQLEILRQQVVSEGGPTATIQSRFNYAWGLIKSTDVNDERLGVKILTDIYKEAESRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHERNNKQVGALKSMVEDKIQKETLKGVVVAGGVLAGAVAVASFFLRNKRR
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division. Location Topology: Single-pass membrane protein Sequence Mass (Da): 17733 Sequence Length: 155 Domain: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. Subcellular Location: Mitochondrion outer membrane
Q59207
MHVTRDFSHYVRTAGEGIKHIDLAVEGVHCAGCMAKIERGLSAIPDVTLARVNLTDRRVALEWKAGTLDPGRFIDRLEELGYKAYPFETESAEVAEVAESRFLLRCLGVAAFATMNVMMLSIPVWSGNVSDMLPEQRDFFHWLSALIALPAAAYAGQPFFRSAWRALSAKTTNMDVPISIGVILALGMSVVETIHHAEHAYFDAAIMLLTFLLVGRFLDQNMRRRTRAVAGNLAALKAETAAKFVGPDEISQVPVAAISPGDIVLLRPGERCAVDGTVIEGRSEIDQSLITGETLYVTAEQGTPVYAGSMNISGTLRVRVSAASEATLLAEIARLLDNALQARSRYMRLADRASRLYAPVVHATALITILGWVIAGASWHDAIVTGVAVLIITCPCALGLAIPTVQTVASGAMFKSGVLLNSGDAIERLAEADHVIFDKTGTLTLPDLEVMNAADIPADIFELAGRLALSSHHPVAAAVAQAAGARSPIVGAVEEAGQGVRADVDGAEIRLGRPSFCGAEALVGDGTRLDPEASIVAFSKGAEKFILWVRQGLRPDAQAVIAALKARNIGIEILSGDREPAVKAAAHALAIPEWRAGVTPADKIARIEELKRRGARVLMVGDGMNDAPSLAAAHVSMSPISAAHLSQATADLVFLGRPLAPVAAAIDSARKALHLMRQNLWLAIGYNVLAVPVAISGVVTPLIAAAAMSGSSILVMLNSLRARSDSREIV
Function: FixI is a pump of a specific cation involved in symbiotic nitrogen fixation. The four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG. Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 77339 Sequence Length: 730 Subcellular Location: Cell membrane
P18398
MSCCASSAAIMVAEGGQASPASEELWLASRDLGGGLRQTELSVPNAYCGTCIATIEGALRAKPEVERARVNLSSRRVSIVWKEEVGGRRTNPCDFLHAIAERGYQTHLFSPGEEEGDDLLKQLILAVAVSGFAATNIMLLSVSVWSGADAATRDLFHWISALIAGPALIYAGRFFYKSAWNAIRHGRTNMDVPIALAVSLSYGMSLHETIGHGEHAWFDASVTLLFFLLIGRTLDHMMRGRARTAISGLARLSPRGATVVHPDGSREYRAVDEINPGDRLIVAAGERVPVDGRVLSGTSDLDRSVVNGESSPTVVTTGDTVQAGTLNLTGPLTLEATAAARDSFIAEIIGLMEAAEGGRARYRRIADRAARYYSPAVHLLALLTFVGWMLVEGDVRHAMLVAVAVLIITCPCALGLAVPVVQVVAAGRLFQGGVMVKDGSAMERLAEIDTVLLDKTGTLTIGKPRLVNAHEISPGRLATAAAIAVHSRHPIAVAIQNSAGAASPIAGDIREIPGAGIEVKTEDGVYRLGSRDFAVGGSGPDGRQSEAILSLDFRELACFRFEDQPRPASRESIEALGRLGIATGILSGDRAPVVAALASSLGISNWYAELSPREKVQVCAAAAEAGHKALVVGDGINDAPVLRAAHVSMAPATAADVGRQAADFVFMHERLSAVPFAIETSRHAGQLIRQNFALAIGYNVIAVPIAILGYATPLVAAVAMSSSSLVVVFNALRLKRSLAAGRGATPGTLIHSGAVTS
Function: FixI is a pump of a specific cation involved in symbiotic nitrogen fixation. The four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG. Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79559 Sequence Length: 757 Subcellular Location: Cell membrane
P23221
MTTKGHIYVIDDDAAMRDSLNFLLDSAGFGVTLFDDAQAFLDALPGLSFGCVVSDVRMPGLDGIELLKRMKAQQSPFPILIMTGHGDVPLAVEAMKLGAVDFLEKPFEDDRLTAMIESAIRQAEPAAKSEAVAQDIAARVASLSPRERQVMEGLIAGLSNKLIAREYDISPRTIEVYRANVMTKMQANSLSELVRLAMRAGMLND
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for FixN activation. PTM: Phosphorylated by FixL. Sequence Mass (Da): 22318 Sequence Length: 205 Subcellular Location: Cytoplasm
P10958
MTDYTVHIVDDEEPVRKSLAFMLTMNGFAVKMHQSAEAFLAFAPDVRNGVLVTDLRMPDMSGVELLRNLGDLKINIPSIVITGHGDVPMAVEAMKAGAVDFIEKPFEDTVIIEAIERASEHLVAAEADVDDANDIRARLQTLSERERQVLSAVVAGLPNKSIAYDLDISPRTVEVHRANVMAKMKAKSLPHLVRMALAGGFGPS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for FixN activation. PTM: Phosphorylated by FixL. Sequence Mass (Da): 22219 Sequence Length: 204 Subcellular Location: Cytoplasm
P26489
MTDTPTQALPPKAPQAGPTVPGTVRRAVPGSAAAALVIAASHFAALSAFDPRILLVLLVIVVLASSGGLFAGLAATAVSALGLALRGLLSGDTVVADWQSLGLLTIAGAGIAVLGERLRRTRLDAVARDRALLAREAHLSSILDTVPDAMIVIDERGIMQSFSITAERLFGYSPSEVIGRNVSMLMPNPHRDQHDLYLSRYLTTGERRIIGIGRVVTGERKDGATFPMELAVGEMHSVSGRFFTGFIRDLTERQNTEARLQELQAELVHISRLTALGEMASTLAHELNQPLSAIANYIKGSRRLLDDGDPKRIPMLQGALDKAAEQALRAGQIIRRLRDFVSRGETERRVESLSKLIEEASALALVGAKEHGIQVRYQIDTSCDLVLADKVQVQQVLLNLMRNALEAMMDASRRQLLVQTTPAEDDMVTVSVCDTGHGISDEMRAQLFTPFVTTKAQGMGVGLSISRTIIEAHGGRIWAEPNAGGGTIFRFTLRTVDEEAMNDA
Cofactor: Binds 1 heme group per subunit. Function: Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54319 Sequence Length: 504 Subcellular Location: Cell inner membrane EC: 2.7.13.3
P23222
MAPTRVTHPPDDGRGEHFRVRIEGFGVGTWDLDLKTWALDWSDTARTLLGIGQDQPASYDLFLSRLEPDDRERVESAIKRVSERGGGFDVSFRVAGTSNAGQWIRARAGLIRDEAGTARHLSGIFLDIDEEKQVEGALRTRETHLRSILHTIPDAMIVIDGHGIIQLFSTAAERLFGWSELEAIGQNVNILMPEPDRSRHDSYISRYRTTSDPHIIGIGRIVTGKRRDGTTFPMHLSIGEMQSGGEPYFTGFVRDLTEHQQTQARLQELQSELVHVSRLSAMGEMASALAHELNQPLAAISNYMKGSRRLLAGSSDPNTPKVESALDRAAEQALRAGQIIRRLRDFVARGESEKRVESLSKLIEEAGALGLAGAREQNVQLRFSLDPGADLVLADRVQIQQVLVNLFRNALEAMAQSQRRELVVTNTPAADDMIEVEVSDTGSGFQDDVIPNLFQTFFTTKDTGMGVGLSISRSIIEAHGGRMWAESNASGGATFRFTLPAADEN
Cofactor: Binds 1 heme group per subunit. Function: Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 55652 Sequence Length: 505 EC: 2.7.13.3
P10955
MLSKSGIERTQWGRRVVRWRGDGVAAYIVAAIVTSSVLAIRMIRAEPIGEGLLLFSFIPAILVVALIGGRNPILFAAGLSLVAAVSHQQISSADGPSVVELLVFGSAVLLIVALGEVLEAARRAIDRTEDVVRARDAHLRSILDTVPDATVVSATDGTIVSFNAAAVRQFGYAEEEVIGQNLRILMPEPYRHEHDGYLQRYMATGEKRIIGIDRVVSGQRKDGSTFPMKLAVGEMRSGGERFFTGFIRDLTEREESAARLEQIQAELARLARLNEMGEMASTLAHELNQPLSAIANYSHGCTRLLRDMDDAVATRIREALEEVASQSLRAGQIIKHLREFVTKGETEKAPEDIRKLVEESAALALVGSREQGVRTVFEYLPGAEMVLVDRIQVQQVLINLMRNAIEAMRHVDRRELTIRTMPADPGEVAVVVEDTGGGIPEEVAGQLFKPFVTTKASGMGIGLSISKRIVEAHGGEMTVSKNEAGGATFRFTLPAYLDERIVAND
Cofactor: Binds 1 heme group per subunit. Function: Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55073 Sequence Length: 505 Subcellular Location: Cell inner membrane EC: 2.7.13.3
P98055
MNYTLETADRALGAFPALLGAAFAHDSLFAAHMWVLFFTLVVSTLLLLRRVSFLPPVAGPPCRRTEYFDEVVKYGVMATVFWGVVGFLVGVVVALQLAFPDLNIAPYFNFGRMRPLHTSAVIFAFGGNALIATSFYVVQRTCRARLFGGNLGWFVFWGYNLFIIMAATGYLLGITQGREYAEPEWYVDLWLTIVWVAYLATFLGTILTRKEPHISVANWFYLSFIVTIAMLHIVNNLAVPVSFLGVKSYSAFSGVQAALTQWWYGHNAVGFFLTAGFLGMMYYFIPKQVNRPVYSYRLSIIHFWALIFMYIWAGPHHLHYTALPDWAQTLGMVFSIMLWMPSWGGMINGLMTLSGAWDKIRTDPIVRMMVMAVAFYGMATFEGPMMSIKAVNSLSHYTDWTIGHVHSGALGWNGMITFGAIYYLTPKLWGRDRLYSLQLVNWHFWLATLGIVVYAAVMWVAGIQQALMWREYDSQGFLVYSFAESVAALFPYYVMRALGGLMFLSGALIMAYNVTMTILGHQREEGASKGAAPSLQPAE
Cofactor: Binds 1 copper ion per subunit, denoted as copper B. Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B. Catalytic Activity: 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60651 Sequence Length: 539 Pathway: Energy metabolism; oxidative phosphorylation. Subcellular Location: Cell membrane EC: 7.1.1.9