ids
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seqs
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11.1k
Q9RW02
MQTSSEPAASETAALLGKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPANLALIAAGREPEALLPPTPRSVRFLLRHALGDDLRGLRVAVIGPGRTVGRPLLFMLNNKGATVTLCNEHTRDLAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGINVQESGDMVGDALPELPVRAQTPVPGGVGPLTSALMYQNLVRGVKLQRGEPVDD
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 31408 Sequence Length: 299 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
C0QAY0
MAEVLKGKPVADALKAELTKNIEALKKDKGITPKLGIIRVGARPDDLFYEGGAKKTCAAVGMDCEIFEYPEDIDQASFEKAVTEVGAKKDVNGILMFSPLPKNLDERKIRTLIPVEKDVDCLTTGGAAKVFTDDATGFPPCTPTACMEMLHFYDIPIKGKKCVVVGRSLVVGKPLAMLLLREHGTVTICHSRTENLPGVCQDADILIAAVGRAKMVKADFVKKGQIVIDVGINADPDRPGKYCGDVDFETVEPVVTKITPVPAGVGSVTTSVLCKQTFMACQMQNA
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30699 Sequence Length: 286 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q6ALZ5
MSAKIISGTEIRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLGFYEVQESLSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKHINEQNIITAIDPDKDVDAFHPVNIGRLMIGGDDVKFLPCTPAGIQEMLVRSGVETAGAEVVVVGRSNIVGKPIAMMMAQKGIGANATVTIVHTGSRDLATHCRRADILIVAAGVPNLVKPEWIKPGATVIDVGVNRVGTNSETGKAILRGDVDFEAVKEIAGKITPVPGGVGPMTIAMLMKNTLASALAHSS
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 31253 Sequence Length: 296 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
A4J3F5
MTKILDGKKIASILREELKQDIITLKERGIEPKLAVVLVGEDPASVAYAKFLQKVSENAGVLFELHQLSKSTAEEEIICKIEDLNQIQAVHGILMMMPLPPHVNKQHIMEHISPLKDVDGLHPFNRGHLISGGICLHPATPTSCLEILKRSGITLAGKHIVVVGRGETVGKPLVFMALAENATVTVCHSRTVDLGKFTKQADIIISAVGKPGLITADMIKPGAVVVDAGIHEEAGNIIGDVDYEQVKEIAEAITPVPGGVGSLTTVLMLKNVLKGIQLQIGTQE
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30460 Sequence Length: 284 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q72F91
MQLLDGKATAATIREELRAEIAALTPRARRAPGLAVILVGEDPASQVYVRNKERACHDTGIVSEAFRLAPTTTQEELERLIADLNVRPDIDGILLQLPLPRGLDAQRCLEAIDPAKDVDGFHPQNMGRLALGLPGFRPCTPAGVMTLLERYDLSPSGRKAVVVGRSNIVGKPLALMLGAPGKYANATVTVCHSGTPDLAAECRTADFLFLAIGRPRFVTADMVREGAVVVDVGINRTETGLAGDCDFEGVSRVASAITPVPGGVGPMTIAQLLVNTVQSWKVRCGL
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30380 Sequence Length: 286 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
A5EX57
MSAEIINGKEIAAEIRREIKQETAQFIAATGVRPGLAVILVGNDPASEVYVRNKGIQAEEVGFLSQIYRLPAQTTQAELLAKIVALNNDPQICGILVQLPLPAHLNAEIVLNTIDPNKDVDGFHPLNIGRLWAGEPCSVPCTPLGCSLILKRYFGDSLAGKKALIIGRSNIVGKPMAALLLQQHATVTIAHSKTPDVPALCRQADIVIAAVGQPELVKGDWIKSGAVVLDVGINRIAVGDKTKLVGDVAFESAKEVAAAITPVPGGIGPMTIACLLKNTLTLAKAIQQSGK
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30659 Sequence Length: 291 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
B8E335
MGVILEGKPVAEKLEKEIKEKIQFYKSQGVIPTLCIVKVGKNAEAEAYAKSIEKFFSKIGINIERKNFNEEISLVDFKKIMKELEEDSAIHGVLILRPLPEELERGKAFQFLPTKKDVEGVTYENLGRLLVGEDSFHPCTPQAVLELLDFYQIPVEGKNVVVVGRSISVGKPLSLLLLNRNATITVCHSKTKNLVEFTKKAEILIVAIGKPYFVGKDMVGEGQVIIDVGTNVVDGKLVGDVNFEEVKDKVEYITPVPGGIGVITTRVLAMNLLKAVKKVEA
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 31034 Sequence Length: 281 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
A9M068
MSAQLINGKEVSQKRLQAVAEAVAQRQQDNLHMPCLAVVLVGGDPASAVYVRNKKTACQKCGIKSLSYELPESTSQEELLALVDRLNADSEVDGILVQLPLPKHLDSQAVLERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLADEVAGADILVVGVGIPNFVKGEWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30110 Sequence Length: 284 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q2GCV3
MTQLIDGFRIAAGICESIATSVAHLRKNNGLVPSLRVIIVGENPASQVYVRSKQKKAESLGIDAETIALPKDTSEVELIRLVNSLNDDTSINAILVQLPLPPHINPTRIIESIDSKKDVDCFHPENVGRLALSKDALLKPCTPAGSLYLIKSALGDNLSGMDAVVIGRSNIVGKPMAMLLLHENCTITLTHSKTRNIQEKTRQADIVISAVGIPHFVKKDFIKPGATVIDVGMNKVDGKLVGDVDFEDVLQKVKFITPVPRGVGPMTIAFLMLNTVITTCLQNKLEHQEVIGTVIQKL
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 32304 Sequence Length: 298 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
A9A4N5
MTGTKIDGKVISQSVKDRVKKAVEELKNQGINPCLATVLVGDNPASATYVRNKHRACEEVGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLLDKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQEKLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAASLSSQIGK
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30956 Sequence Length: 287 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q05213
MKILRGEEIAEKKAENLHGIIERSGLEPSLKLIQIGDNEAASIYARAKIRRGKKIGIAVDLEKYDDISMKDLLKRIDDLAKDPQINGIMIENPLPKGFDYYEIVRNIPYYKDVDALSPYNQGLIALNREFLVPATPRAVIDIMDYYGYHENTVTIVNRSPVVGRPLSMMLLNRNYTVSVCHSKTKDIGSMTRSSKIVVVAVGRPGFLNREMVTPGSVVIDVGINYVNDKVVGDANFEDLSEYVEAITPVPGGVGPITATNILENVVKAAEFQKNNL
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30622 Sequence Length: 276 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q9X288
MWIDCKTIARSIEERTKERVEKLGFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEIMNVSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVDGKLQGDVDPSVEEIARVTPVPGGVGQVTTALLFEHVVRAAERQRK
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 29557 Sequence Length: 271 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
B9KZ23
MAAHILSGRPVVESLHARIQQVLARRAPHQGPPTLTVLLPNDPSAQAYARAIRKQFTTLSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDVDGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLLARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVSVRDGRLIGDVDPAVAEVASALTPVPGGTGPVTTAVLALNLLRLAGLLEENDLFPGAP
Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH Sequence Mass (Da): 30631 Sequence Length: 288 Pathway: One-carbon metabolism; tetrahydrofolate interconversion.
Q5WE80
MVNGINHMTFSVSNMDKAVSFYKHVFMEAPLVLGEKTAYFTIGGTWLALNLQPDIDRKEIRQSYTHIAFSIEESQLDAFYTRLLEAGADILPGRKRQVETEGKSIYFRDPDGHLLEVHTGTLAERLAHYEKTAPDMLVNIDEQNKK
Function: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. Sequence Mass (Da): 16647 Sequence Length: 146 Subcellular Location: Cytoplasm EC: 2.5.1.-
O31817
MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMNGIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDRKSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF
Function: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. Sequence Mass (Da): 17172 Sequence Length: 144 Subcellular Location: Cytoplasm EC: 2.5.1.-
Q99958
MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYSAGMGRSYAPYHHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEPPPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAGSPDGSLPEHHAAAPNGLPGFSVENIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPAAYGQPCAQGLEAGAAGGYQCSMRAMSLYTGAERPAHMCVPPALDEALSDHPSGPTSPLSALNLAAGQEGALAATGHHHQHHGHHHPQAPPPPPAPQPQPTPQPGAAAAQAASWYLNHSGDLNHLPGHTFAAQQQTFPNVREMFNSHRLGIENSTLGESQVSGNASCQLPYRSTPPLYRHAAPYSYDCTKY
Function: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. PTM: Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin. Sequence Mass (Da): 53719 Sequence Length: 501 Subcellular Location: Nucleus
Q61850
MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYGAGMGRSYAPYHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVPKDKEERAHLKEPPSTTAKGAPTGTPVADGPKEAEKKVVVKSEAASPALPVITKVETLSPEGALQASPRSASSTPAGSPDGSLPEHHAAAPNGLPGFSVETIMTLRTSPPGGDLSPAAARAGLVVPPLALPYAAAPPAAYTQPCAQGLEAAGSAGYQCSMRAMSLYTGAERPAHVCVPPALDEALSDHPSGPGSPLGALNLAAGQEGALGASGHHHQHHGHLHPQAPPPAPQPPPAPQPATQATSWYLNHGGDLSHLPGHTFATQQQTFPNVREMFNSHRLGLDNSSLGESQVSNASCQLPYRATPSLYRHAAPYSYDCTKY
Function: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. PTM: Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin. Sequence Mass (Da): 52874 Sequence Length: 494 Subcellular Location: Nucleus
Q89WC9
MPELPEVETVRRGLQPVMEGAKIVVAEARRPDLRFPFQPDFVARLQGQVVTGLGRRAKYLMADLASGDVLLMHLGMSGSFRVIKPDNDAAPGEFHYPRGKDTTHDHVLFRMSSGADIVFNDPRRFGYMKVIARNALEDEPLLRGLGPEPLGNEFDAAMLARSCEGKATSLKAALLDQRVVAGLGNIYVCEALHRSHLSPRRIAATLATRKGEPTDHAKRLVGAIHTVLNDAIKAGGSSLRDHRQTTGELGYFQHSFKVYDREGETCKTPACGGTIKRFTQNGRSTFWCPKCQK
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Catalytic Activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. Sequence Mass (Da): 32309 Sequence Length: 293 EC: 3.2.2.23
A9HI30
MPELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYILIRLDTGDTLLLHLGMSGRVLLSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDLMPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSIKAALLDQTVVAGLGNIYVSEALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAWRVYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Catalytic Activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. Sequence Mass (Da): 31343 Sequence Length: 286 EC: 3.2.2.23
Q7VN67
MPELPEVETCLRGIEPYLAGQTIQQIVIRTPKLRWPISAELCAMSGAKILALSRRAKYLIIHTERGDILVHLGMSGSLTLLNSSQPTKASKHDHVDLITEAGIILRYNDPRKFGAWLWAKQAENYPLITKLGPEPLSDTFTSDYLFKKSRNKTVAVKNFIMNNDIVVGVGNIYASESLFMAGVHPELAAQNLTEKQCVQLRNVIQAVLTKAIIQGGTTLKDFTQPDGKPGYFAQVLQVYGRKGEECRECGTLIQAKVIGQRNSYFCPDCQPLPK
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Catalytic Activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. Sequence Mass (Da): 30443 Sequence Length: 274 EC: 3.2.2.23
A1WZG2
MPELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYLLIRLGGGAWLLLHLGMSGSLRLVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGDGDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKALLMDATVVVGVGNIYANEALFRAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVYGASVCPVCGGALRQIRLAQRGTWFCPRCQR
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Catalytic Activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. Sequence Mass (Da): 29314 Sequence Length: 270 EC: 3.2.2.23
B0TER7
MPELPEVETVRRSLAGRITGLTIEKVELRLPKIAFALPGTLFTDALRGRRIIELGRRGKYLLLHLDGDETLVIHLRMTGRLIHLRPEEREEPEAAHTHAVFFLDDGSLLRYTDVRQFGTLTLMTREAALRQPGKGRLGPEPLGQDFSFVDFRNALVKRKTKLKPLLLDQSFLAGLGNIYADEALARARLHPDRTADSLDDEESRRLYDCIRTVLQEGIDAKGTSFRDYVDGEGRKGEFQEKLWVYGRGGNPCRRCGGEILREKRAGRSTHFCPRCQK
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Catalytic Activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. Sequence Mass (Da): 31478 Sequence Length: 277 EC: 3.2.2.23
P23900
MSNPQKALNDFLSSESVHTHDSSRKQSNKQSSDEGRSSSQPSHHHSGGTNNNNNNNNNNNNSNNNNNGNDGGNDDDYDYEMQDYRPSPQSARPTPTYVPQYSVESGTAFPIQEVIPSAYINTQDINHKDNGPPSASSNRAFRPRGQTTVSANVLNIEDFYKNADDAHTIPESHLSRRRSRSRATSNAGHSANTGATNGRTTGAQTNMESNESPRNVPIMVKPKTLYQNPQTPTVLPSTYHPINKWSSVKNTYLKEFLAEFMGTMVMIIFGSAVVCQVNVAGKIQQDNFNVALDNLNVTGSSAETIDAMKSLTSLVSSVAGGTFDDVALGWAAAVVMGYFCAGGSAISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVLQEAYSDWWMNESVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVNWSLPVYKEMIMRAWFRRPGWKKRNRARRTSDLSDFSYNNDDDEEFGERMALQKTKTKSSISDNENEAGEKKVQFKSVQRGKRTFGGIPTILEEEDSIETASLGATTTDSIGLSDTSSEDSHYGNAKKVT
Function: Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 73877 Sequence Length: 669 Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Leu-Ala/Ser (NPA). Subcellular Location: Membrane
P00541
ASGQLHRPQPQEHTSTSAAAGTWRHTQASESRHRLPHCSAAPSHQDHSAMGFGPELWCPKGHSELLRLQDSELRLLELMKKWMSERAKSDREYAGMLHHMFSQLGSEEPPPALPLQEDRQSVCSTDQERSGVTALETIKNHISGIFSPRFSLPPPVPLIPEVQKPLCQQAWYHGAIPRSEVQELLKCSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQAADNLYRLEGDGFPTIPLLIDHLLQSQQPITRKSGIVLTRAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPHLKMKELIKMMENAAAGMEYLESKHCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGRYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAIEQGVRLEPPEQCPEDVYRLMQRCWEYDPRRRPSFGAVHQDLIAIRKRHR
Catalytic Activity: ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Sequence Mass (Da): 60506 Sequence Length: 533 Domain: The F-BAR domain is truncated and contains only the FCH region (the coiled-coil region is missing). EC: 2.7.10.2
Q9NH03
MNNQSLQRAAMISEHLAPTSELNMNQTSAPIKTAKEELADFVEIFPILTNEILKELPGMDMPPQTIAWVEKMINVNVSGGKMNRGLTVLHSLQLLVEGRQLSRSEIFLANVLGWCVEWLQAFFLVADDIMDQSITRRGQPCWYRQANPISNNGTIGSIAINDSFILESCIYILIKKYFRNEPYYADILDIFHETSYQTELGQLLDLTTQPNRGDFSLFTLNTYRRIVKYKTAYYSFYLPVALAMLMAGITSTPAFSTAKDILLPMGEFFQVQDDFLDCYGSPAVIGKIGRDIEENKCSWMICQAILNGTPEQINLLKKHYGLDNPTDVELVKKIYGEIGLKKIFKDYEDESYAFLISKIKSVRIMPQEVFIKLLSKIYKRDL
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a sterol precursor. Involved in the inhibition of cell growth. Catalytic Activity: dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate Sequence Mass (Da): 43590 Sequence Length: 382 Pathway: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Subcellular Location: Cytoplasm EC: 2.5.1.10
Q4JHN6
MSDLKTRFLEVYSVLKSELLNDPAFEFTDDSRQWVERMLDYNVPGGKLNRGLSVIDSYKLLKEGKELSDDEIFLSSALGWCIEWLQAYFLVLDDIMDSSHTRRGQPCWFRLPKVGMIAVNDGILLRNHIPRILKKHFRQKPYYVDLLDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLPIHRRIVQYKTAYYSFYLPVACALLMSGEDLEKHTNVKDILIEMGTYFQVQDDYLDCFGAPEVIGKIGTDIEDFKCSWLVVKALELSNEEQKKFLHENYGKDDPASVAKVKELYNTLKLQDVFAEYESKSYDKLIKFIEAHPSQAVQAVLKSFLGKIYKRQK
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways . Promotes the accumulation of ginsenosides . Catalytic Activity: dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate Sequence Mass (Da): 39627 Sequence Length: 342 Pathway: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Subcellular Location: Cytoplasm EC: 2.5.1.10
P42512
MKTETKVIKGRQGIARNRHTPLCLGLLLALSPLAAAVADARKDGETELPDMVISGESTSATQPPGVTTLGKVPLKPRELPQSASVIDHERLEQQNLFSLDEAMQQATGVTVQPFQLLTTAYYVRGFKVDSFELDGVPALLGNTASSPQDMAIYERVEILRGSNGLLHGTGNPAATVNLVRKRPQREFAASTTLSAGRWDRYRAEVDVGGPLSASGNVRGRAVAAYEDRDYFYDVADQGTRLLYGVTEFDLSPDTLLTVGAQYQHIDSITNMAGVPMAKDGSNLGLSRDTYLDVDWDRFKWDTYRAFGSLEQQLGGGWKGKVSAEYQEADSRLRYAGSFGAIDPQTGDGGQLMGAAYKFKSIQRSLDANLNGPVRLFGLTHELLGGVTYAQGETRQDTARFLNLPNTPVNVYRWDPHGVPRPQIGQYTSPGTTTTTQKGLYALGRIKLAEPLTLVVGGRESWWDQDTPATRFKPGRQFTPYGGLIWDFARDWSWYVSYAEVYQPQADRQTWNSEPLSPVEGKTYETGIKGELADGRLNLSLAAFRIDLENNPQEDPDHPGPPNNPFYISGGKVRSQGFELEGTGYLTPYWSLSAGYTYTSTEYLKDSQNDSGTRYSTFTPRHLLRLWSNYDLPWQDRRWSVGGGLQAQSDYSVDYRGVSMRQGGYALVNMRLGYKIDEHWTAAVNVNNLFDRTYYQSLSNPNWNNRYGEPRSFNVSLRGAF
Function: High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79992 Sequence Length: 720 Subcellular Location: Cell outer membrane
P42513
MPRQSGFGWAWRVPLALAGSLAAATASGYLLTRGLPLDDPLERLYAGLFGALGVGLLLLVGGLLARGPGNFAWRLGGSLLVLGLALWLLAGRG
Function: May play some role in transport of Fe(3+)-pyochelin. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 9569 Sequence Length: 93 Subcellular Location: Cell membrane
Q81L65
MKKILSIFIVVFLFAVGCGQQKEEKKETKADNKNQAITIKHAEGETKLDKPAKKVVVLEWVYSEDLLALGVQPVGMADIKNYNKWVNTKTKPSKDVVDVGTRQQPNLEEISRLKPDLIITASFRGKAIKNELEQIAPTVMFDPSTSNNDHFAEMTETFKQIAKAVGKEEEGKKVLADMDKAFADAKAKIEKADLKDKNIAMAQAFTAKNVPTFRILTDNSLALQVTKKLGLTNTFEAGKSEPDGFKQTTVESLQSVQDSNFIYIVADEDNIFDTQLKGNPAWEELKFKKENKMYKLKGDTWIFGGPESATSLATQVADVMTAKK
Function: Part of an ABC transporter complex involved in ferric-petrobactin uptake. Location Topology: Lipid-anchor Sequence Mass (Da): 36074 Sequence Length: 324 Subcellular Location: Cell membrane
Q81L64
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIMLRLPRAVIAILAGGALAASGVILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQINSLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLMLSAFTGTMQLFYENETAGLFLWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIAFIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGRLIDPTGAELPVGAVTAMIGSPWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIIISITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMMMNLRLPRMLVAAIAGACLAISGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVLFFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLENIILYPSLILVLIIFFLIKQLDVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVGTIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIADLLGRTIAYPKEIPSGLVVAVLGAPYFLWLMRKSGKKVN
Function: Part of an ABC transporter complex involved in ferric-petrobactin uptake. Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 72025 Sequence Length: 678 Subcellular Location: Cell membrane
Q81LM1
MISVNKVFYAHSERFQMQNMNVHIKAGEVVSLIGPNGSGKSTLLRLMARLLKQSEGDIVLDGKSIHTMKSADVAKQLAMLPQMHDHQLDLTVKELIEFGRGPHKSWRGRLNKEDEEIVDWALSVTNLEGYEYRLLQSLSGGERQRAWIAMTLAQRTNVLLLDEPTTFLDIVHQLEVMELVKRLNEEFGMTIIMVLHDINQAAQYSDRLLVLKRGKLQYDGVPEEVLCHEMFQHIFGIEVDIFQGSEKPFFTPKRISKKGGAKCEQKNVLPLS
Function: Part of an ABC transporter complex involved in ferric-petrobactin uptake. Probably responsible for energy coupling to the transport system. Catalytic Activity: a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate Location Topology: Peripheral membrane protein Sequence Mass (Da): 30996 Sequence Length: 272 Subcellular Location: Cell membrane EC: 7.2.2.-
Q81V82
MQKALETKRLTLSYGETIIIDELNLEIPKGEITIFIGSNGCGKSTLLRSLARLLKPTTGDILLDNQAIQSMQTKQIARQMAILPQGPQAPEGLTVLQLVKQGRYPYQTWLKQWSEKDEEMVQNALAATGMTEFAERDVHALSGGQRQRAWIAMTLAQDTDIILLDEPTTYLDMTHQIEVLDLLFELNETEQRTIVMVLHDLNLACRYADNIVAIQDKQIYAQGKPEEVVDEKLVRDVFRMECQISTDPLFGTPLCIPHGKGRRVRKEVAHAMR
Function: Part of an ABC transporter complex involved in ferric-petrobactin uptake. Probably responsible for energy coupling to the transport system. Catalytic Activity: a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate Location Topology: Peripheral membrane protein Sequence Mass (Da): 30887 Sequence Length: 273 Subcellular Location: Cell membrane EC: 7.2.2.-
P48632
MPAPHGLSPLSKAFLMRRAFQRRILPHSLAMALSLPLAGYVQAQEVEFDIPPQALGSALQEFGRQADIQVLYRPEEVRNKRSSAIKGKLEPNQAITELLRGTGASVDFQGNAITISVAEAADSSVDLGATMITSNQLGTITEDSGSYTPGTIATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYARGFSINNFQYDGIPSTARNVGYSAGNTLSDMAIYDRVEVLKGATGLLTGAGSLGATINLIRKKPTHEFKGHVELGAGSWDNYRSELDVSGPLTESGNVRGRAVAAYQDKHSFMDHYERKTSVYYGILEFDLNPDTMLTVGADYQDNDPKGSGWSGSFPLFDSQGNRNDVSRSFNNGAKWSSWEQYTRTVFANLEHNFANGWVGKVQLDHKINGYHAPLGAIMGDWPAPDNSAKIVAQKYTGETKSNSLDIYLTGPFQFLGREHELVVGTSASFSHWEGKSYWNLRNYDNTTDDFINWDGDIGKPDWGTPSQYIDDKTRQLGSYMTARFNVTDDLNLFLGGRVVDYRVTGLNPTIRESGRFIPYVGAVYDLNDTYSVYASYTDIFMPQDSWYRDSSNKLLEPDEGQNYEIGIKGEYLDGRLNTSLAYFEIHEENRAEEDALYNSKPTNPAITYAYKGIKAKTKGYEAEISGELAPGWQVQAGYTHKIIRDDSGKKVSTWEPQDQLSLYTSYKFKGALDKLTVGGGARWQGKSWQMVYNNPRSRWEKFSQEDYWLVDLMARYQITDKLSASVNVNNVFDKTYYTNIGFYTSASYGDPRNLMFSTRWDF
Function: Receptor for the siderophore ferripyoverdine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 91167 Sequence Length: 815 Subcellular Location: Cell outer membrane
A0A1L7U2E9
MSLPKAQILVVVTVGGSTNSAPILEICSILAARGHTIDFATLSGRQKLVDNYPFVKKVHIVGPAISAEEDEKHYILFSRWNWNTARGKRDIVKGKMAFDAFWPFTYRGLKEVITTTKPDFIFSDFHVEAALDVCNEFRLPHAVMWPQMPWLMMPQKYIPGQPGMQQRCLTSEHASIYDRLFEMTFLLRSAPFFLHWIFWTKAMRRKEGVAPRPRHSKPDYLVFMNNFYGMETPRDTPPLVHPVGPILADSYPALDGDIKSFVETHQKIALVAFGTHVILDDGKIFKIIDGLADAISSGVIDGVVWALSARSRGQLDTSIRVPSLHLSHLTIDQLFKNQDQAWHFATWVPQRSVLEHDSTIIFVTHAGPSSVNESIFHGVPMVAMGIFGDQMVTTLRLERSGVAVRLDKETFDAASLTTAIRTILLFDKESFQRNVKRMKRIAMVGSRKKHFAANVIEEHLYDWDGRFENSILDLKACSNRKRGFLQASNSKDMYPRGKELRPMHLQTPDVRMSWIKLNNIDVALLFFILLGIISWITRAAANMVRL
Function: UDP-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable). Location Topology: Single-pass membrane protein Sequence Mass (Da): 62050 Sequence Length: 546 Pathway: Secondary metabolite biosynthesis. Subcellular Location: Membrane EC: 2.4.1.-
A0A1L7TZY0
MRILCLHGMGTNSKVLEMQTSALRHQLSHSQSHKYEYVDGGEPMPPAPGIEAFIGQDESLAYYHPHSAKSILTAIDDLWEYIAEEGPFDGVLGFSQGASLAAMIIARAHHSDPPPFQFAIFFCAGLPYCEKSLSAGEVKFLRAEATQGPVIHVPTAHIFGKKDPDVSYSKAMTELCHPWGRVLLDHGAGHEIPRVPVETVDDMARAVEKVVTKAVIGQ
Function: Esterase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable). Sequence Mass (Da): 23787 Sequence Length: 218 Pathway: Secondary metabolite biosynthesis. EC: 3.1.2.-
A0A1L7TV57
MPNLEKEFHNGVNGLNGNTKIENDGCVNPHSLGIIGGGWYGCHIAATLLALGFRVKLFEQHERLLHEASGNNQFRLHMGFHYARHSGTRLQSRDGFLRFVEHYPELSRIVPYNIYAVPTQDSLLDYNTYKAIMASSGVAFTEGAPDGVHITNVDGIMCVPERVLLLTKARAYFEAALKGALELGRKVSSIQEADDGVLIDGEGFDFVVDATWGHYMDLDLQVIYEATLLLYYEGPPEFPAVTLVDGPLASVYPTEVPGVFTLSSVPHTPLGQFKTAAEARAARDGVSPATISAKRALMEEQIMHYLPTFLETFRYIGPQLAVKTKPLGAYDDRSCRVSRRGRMFSVMSGKIDTIFFAHERILSLIDDES
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable). Sequence Mass (Da): 40862 Sequence Length: 369 Pathway: Secondary metabolite biosynthesis. EC: 1.14.13.-
A0A1L7TV54
MSETTGLPLKHLQGSPPGTPVNTNNESNEASPDDGCRLPDTVTEAEASSDNHGSVLGDNNRNVEVAVGASDNATKQKVYHTGWRLHALTSALCLSLLLSTLETTIVSTALVSIVDALHGFNMAGWIVTSYLVTYTGFLIIYSKLSDIFGCKLMLLLAITIFTVFSMACGASDSMVPLIVFRAFQGMGGSGIYSLSTIMVPLMVPPEKYATYISIMSSTFILSSVLGPILGGAITDHTTWRWVFYFNGPGGALAAVLLAFSVPFNFPYGESDRFFHSLASKQMWKRVDFVGMTVSLAASILIIFALEQGGVAYPWGSGAIVSTFVLSGVLWIAFIAWERLLSKRDGVREPMFPWSLVHNRFVMGLLLNGFFTGFPFMAALINIPQRFQTVNMTSAINAGIRTLPLLLLSPLATAINGILVSKLRVPPLYTLFLGGSLQTIGVGLYSSLKSSTSIASAQYGYEAIMGLGFGFNLSTILMMVPLVVTEKDLAVTMGSVTQIRVLGGTIGLAVCSALLINHIKREAVKFLTAEQVAQILLSSENIGMLSIETQSRTRVLYADAYSEQMRVMLYFSIASILSLVLLVERQPRKAPAKPERAG
Function: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64433 Sequence Length: 597 Pathway: Secondary metabolite biosynthesis. Subcellular Location: Membrane
A0A1L7U5T4
MVGIALLGAGIFAREQHLPAIESVGHLNLKAVYSRSEEAAISLAKQARDRVDIYFDSPPTSGRSLDDLLARSDIAAVAACATILVQPLLIRKALRAGKHVLSEKPIAQDTATAMGLVQWYSSQSSPPIWAVAENFRFNESLRYAEMRTQEIGGELASFRLTYYGLIRKENKYFKTEWRKTPEFQGGFLLDSGIHFIASLRLLLRAVGQEPKEVMALSSLLKEHLHPVDTIHAVVSTIDSRHGTVCISFGVEHISTLEIEIISTRGVIVWTPVSVTSIIKSDSGESMNEKKEFIYNNGVKAEFEAFCQAILQNSPDPRQSPLEALRDLALLQSLLGSAACDGSMKLVKFE
Function: Dehydrogenase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable). Sequence Mass (Da): 38471 Sequence Length: 349 Pathway: Secondary metabolite biosynthesis. EC: 1.1.1.-
A0A1L7TV75
MAIIPWKAIDESLSLRWKIIVTLLAIYTLRIIGTRITTTRARRKFREQHGCAPVTCQLPLKDPFFGIDFILKLMRVFKEKRLLETFANDFYKTVGITFLVERGSQQTIFTIDPENIKTVLALKFKDYGLAFRAPLFNPVTGGGMFVSDGEEWAHSRALMRPTFARDQVADLALTNRHVTDLVSKIPINTTFNLQELLFDFTMDTGTEFLFGESTDTLCNPTKASQEFTKAFDFTLKDVAYQARLGPLRRFQGSRSKALEVYQVCRSYVERYVDQAMALRTSTLTGEVTRENEPQNRHDSLLRQLARSGVSKEKIRAELLSVLIAARDTTSNLLGNLFFVLARRPDIWTKIRDEVKHLDTNEPTYEQLRHLTYAKYCINESLRLHPPVPSNGRMAYRDTILPHGGGPNGDHPIHVPKGSMVNYTVYAMHRRKDLYGQDAEEFRPERWESLRPSWFFLPFNGGPRICLGQQYAITESLLVIMRFAQEFTSIQSMDAKPWTEEIALGCGNANGVYVSFQKLK
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable). Location Topology: Single-pass membrane protein Sequence Mass (Da): 59449 Sequence Length: 519 Pathway: Secondary metabolite biosynthesis. Subcellular Location: Membrane EC: 1.-.-.-
P80489
MTKVVEISPTTRLEGHSKLTLKVDDQGIVERGDWLSITPVRGIEKLAIGKTMEQVPKIASRVCGICPIAHTLASTEAMEASIGCEIPTDAKLLRTILHAANRIHSIALHNILILPDFYIPGTEKKFNLFANEQPARSVMARIVRIREIAQTIGAIAGGEAIHPSNPRIGGMYYNVSPRAKQKMADLAKEGLVLVHEQMEFMFDVIRNMQNREFVEVAGKQIPLPKKLGYHNQGVMATASMYGSSSLDDNPTWDFTRWKETRPWDWYMGEVTIDLEDPSYPIGGTTKIGTKANPQMEACTGVPTYDGQPVEVGPRARLATFKNFDEKGTFAQHIARQMEYPDCCYTILRCLDNLNTSGKVLADHIPQGDGSMGWAANEAPRGSNIHLARVKDGKVLWYDMLVPTTWNFPTCSRALTGAPWQIAEMVVRAYDPCVSCATHMIVVNEEEKIVTQKLMQW
Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Location Topology: Peripheral membrane protein Sequence Mass (Da): 50769 Sequence Length: 456 Subcellular Location: Cell membrane EC: 1.12.98.1
Q60338
MEVNFVTNRIEIAPTTRHEGHAKLILEVDEEGIVNKAYYLNTTPVRGFETMLKGKPAEFAPIAVMRICGICQTTHGIASCEAIENAIDCEVPDDGLLLRELVGIGNRLHSHPLHHLLTIDDFLKPDETDLKIELIKLIQRMRKVGQLVVDIVGGEGIHPPNIVIGGMRTNITERAKSRLYYALRQYEKDAYELYEKYTELIERYLEEIGIPDLGAHEYPYIATHTTYGDRYAINWDDVTEIPAQRYYDDEEAKQTTTIQIPLYAGVPAEGGPRARMVKFGNFREGGSAMDINIARAQENLGAVYRALEILDELDLNGKTRAEVEYKDGFGIGVHEAPRATNTHMAEVGKDGKIKSYRIIAASTWNFPIVEKAIEGYPQQYAEVIMRAYDICASCATHVIVKDEETKEIIEVRKML
Cofactor: There are 12-13 Fe atoms/(alpha(1)beta(1)gamma(1)) unit of the FRH. Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 46784 Sequence Length: 415 EC: 1.12.98.1
P19496
MSERIVISPTSRQEGHAELVMEVDDEGIVTKGRYFSITPVRGLEKIVTGKAPETAPVIVQRICGVCPIPHTLASVEAIDDSLDIEVPKAGRLLRELTLAAHHVNSHAIHHFLIAPDFVPENLMADAINSVSEIRKNAQYVVDMVAGEGIHPSDVRIGGMADNITELARKRLYARLKQLKPKVDEHVELMIGLIEDKGLPKGLGVHNQPTLASHQIYGDRTKFDLDRFTEVMPESWYDDPEIAKRACSTIPLYDGRNVEVGPRARMVEFQGFKERGVVAQHVARALEMKTALARAIEILDELDTSAPVRADFDERGTGKLGVGAIEGPRGLDVHMAQVENGKIQFYSALVPTTWNIPTMGPATEGFHHEYGPHVIRAYDPCLSCATHVMVVDDEDRSVIRDEMVRL
Cofactor: There are 12-13 Fe atoms/(alpha(1)beta(1)gamma(1)) unit of the FRH. Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 44802 Sequence Length: 405 EC: 1.12.98.1
Q00390
MGKTVEINPTTRHEGHTKLVLKVDDDGIVEKGNYLSVTPVRGFEKFLVGKPAEFAPIAVSRFCGICPIAHATSAVEAIEDACGIVPPKDGLLLRELTGLGNKMHSHPLHEFLIAPDFIPEKDRVEYITRIQQMRKTGQYIVDTIGGEAIHAPNIKVGGMLKSITPSAVSKIYYKCKEFEKLAKEQVEYLIPIFENRTLVDGTEIPEKLGYHDFGYLATDSTYGNRENIEQKKVHEYTPYDVYEKEVAVQACQLFQEYNGRLMEVGPRARFAKFHDFKEKGAMAIHIARAYENVIHVKRAMEIIEELNVDGLTRAKDPILGDGEKLGLGVHEAARGHNTHQASIDEKGRITYYNAIVATTWNIPLIGKAVEAHYKFAEHVVRAYDPCVSCATQHDILRL
Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 44612 Sequence Length: 398 EC: 1.12.98.1
P19499
MVLGTYKEIVSARSTDREIQKLAQDGGIVTGLLAYALDEGIIEGAVVAGPGKEFWKPEPMVAMTSDELKAAAGTKYTFSPNVLMLKKAVRQYGIEKLGTVAIPCQTMGIRKAQTYPFGVRFVADKIKLLVGIYCMENFPYTSLQTFICEKLGLNMELVEKMDIGKGKFWVYTQDDVYTLPLKETHGYEQAGCKICKDYVAELADVSTGSVGSPDGWSTVITRTDSGDSILKQAVEAGIFETKPIEEVKPGLGLLEKLSAQKKEKAEKNIAARKEMGLPTPY
Cofactor: There are 12-13 Fe atoms per alpha/beta/gamma unit of the FRH. Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 30771 Sequence Length: 281 EC: 1.12.98.1
P80491
MTNKIKIGHVHMSGCTGCLVSLADNNLGLIKILDDYADLVYCLTLADVRHIPEMDVALVEGSVCLQDHESVEDIKETRKKSKIVVALGSCACYGNITRFSRGGQHNQPQHESYLPIGDLIDVDVYIPGCPPSPELIRNVAVMAYLLLEGNEEQKELAGKYLKPLMDLAKRGTSGCFCDLMYDVINQGLCMGCGTCAASCPVHAITLEFGKPQGERDLCIKCGSCYGACPRSFFNLDVIPEFENINEIIANALKEGESDD
Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 28241 Sequence Length: 259 EC: 1.12.98.1
P19498
MAEENAKPRIGYIHLSGCTGDAMSLTENYDILAELLTNMVDIVYGQTLVDLWEMPEMDLALVEGSVCLQDEHSLHELKELREKAKLVCAFGSCAATGCFTRYSRGGQQAQPSHESFVPIADLIDVDLAIPGCPPSPEIIAKAVVALLNNDMEYLQPMLDLAGYTEACGCDLQTKVVNQGLCTGCGTCAMACQTRALDMTNGRPELNSDRCIKCGICYVQCPRSWWPEEQIKKELGL
Cofactor: There are 12-13 Fe atoms per alpha/beta/gamma unit of the FRH. Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 25817 Sequence Length: 236 EC: 1.12.98.1
Q00393
MVKIAHIHMSGCTGCLISLTDTYEKLLDILGSVELVYALTLTGEKTEITETDDKILIERDIPGGIDIALVEGSVCLDDHHSMDDILTTRKNSKKSLVALGACAASGGVTRFRRVGQMSQPSHASFVPIGDVIKVDLALPGCPPSTESIVKLLTAALEGDMEYLEPFAEIAKYGKDACGCDVIKEVINKSLCMGCGTCAAACQVNAIDMVEAKPNINSEFCIKCGICSAQCPRVRFPEIIRKLE
Function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Catalytic Activity: H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n) Sequence Mass (Da): 26040 Sequence Length: 243 EC: 1.12.98.1
Q39101
MASNALSSFTAANPALSPKPLLPHGSASPSVSLGFSRKVGGGRAVVVAAATVDTNNMPMTGVVFQPFEEVKKADLAIPITSHASLARQRFADASEAVINEQINVEYNVSYVYHSMYAYFDRDNVAMKGLAKFFKESSEEERGHAEKFMEYQNQRGGRVKLHPIVSPISEFEHAEKGDALYAMELALSLEKLTNEKLLNVHKVASENNDPQLADFVESEFLGEQIEAIKKISDYITQLRMIGKGHGVWHFDQMLLN
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Catalytic Activity: 4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O Sequence Mass (Da): 28178 Sequence Length: 255 Subcellular Location: Plastid EC: 1.16.3.1
Q96540
MASKALSSFTAKPAVSLLPHGVSSSASPSVMSLSFSRHTGGRGVVAASSTVDTNNMPMTGVVFQPFEEVKKADLAIPITSNASLARQRYADSSEAAINEQINVEYNVSYVYHSMYAYFDRDNVALKGLAKFFKESSDEEREHAEKFMEYQNQRGGRVTLHPIVSPISDFEHAEKGDALYAMELALSLEKLTNEKLLNLHRVASENNDPQLADFVESEFLGEQIEAIKKISDFITQLRMVGKGHGVWHFDQMLLN
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Catalytic Activity: 4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O Sequence Mass (Da): 28169 Sequence Length: 254 Subcellular Location: Plastid EC: 1.16.3.1
P36088
MGSSTGFHHADHVNYSSNLNKEEILEQLLLSYEGLSDGQVNWVCNLSNASSLIWHAYKSLAVDINWAGFYVTQASEENTLILGPFQGKVACQMIQFGKGVCGTAASTKETQIVPDVNKYPGHIACDGETKSEIVVPIISNDGKTLGVIDIDCLDYEGFDHVDKEFLEKLAKLINKSCVFK
Function: Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress. Catalytic Activity: [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide Sequence Mass (Da): 19734 Sequence Length: 180 Subcellular Location: Cytoplasm EC: 1.8.4.14
Q9LMM2
MGVGEMNKEVIDKVIKFLMMVILMGTIVIWIMMPTSTYKEIWLTSMRAKLGKSIYYGRPGVNLLVYMFPMILLAFLGCIYLHLKKSTTVNQFNSGVEKKRAKFGALRRPMLVNGPLGIVTVTEVMFLTMFMALLLWSLANYMYRTFVNVTSESAATDGNNLWQARLDLIAVRIGIVGNICLAFLFYPVARGSSLLAAVGLTSESSIKYHIWLGHLVMIIFTSHGLCYFIYWISKNQLVSKMLEWDRTAVSNLAGEIALVAGLMMWVTTYPKIRRRLFEVFFYSHYLYIVFMLFFVFHVGISHALIPLPGFYIFLVDRFLRFLQSRNNVKLVSARVLPCDTVELNFSKNPMLMYSPTSTMFVNIPSISKLQWHPFTIISSSKLEPETLSVMIKSQGKWSTKLYDMLSSSSSDQINRLAVSVEGPYGPSSTDFLRHESLVMVSGGSGITPFISIVRDLFYMSSTHKCKIPKMTLICAFKNSSDLSMLDLILPTSGLTTDMASFVDIQIKAFVTREEKTSVKESTHNRNIIKTRHFKPNVSDQPISPILGPNSWLCLAAILSSSFMIFIVIIAIITRYHIHPIDQNSEKYTWAYKSLIYLVSISITVVTTSTAAMLWNKKKYYAKNDQYVDNLSPVIIESSPQQLISQSTDIHYGERPNLNKLLVGLKGSSVGILVCGPKKMRQKVAKICSFGSAENLHFESISFSW
Function: Ferric chelate reductase involved in iron reduction in roots (By similarity). May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79600 Sequence Length: 704 Subcellular Location: Membrane EC: 1.16.1.7
P92949
MEIEKSNNGGSNPSAGEEFKDMIKGVTKFLMMVIFLGTIMLWIMMPTLTYRTKWLPHLRIKFGTSTYFGATGTTLFMYMFPMMVVACLGCVYLHFKNRKSPHHIDRETKGGVWSKLRKPMLVKGPLGIVSVTEITFLAMFVALLLWCFITYLRNSFATITPKSAAAHDESLWQAKLESAALRLGLIGNICLAFLFLPVARGSSLLPAMGLTSESSIKYHIWLGHMVMALFTVHGLCYIIYWASMHEISQMIMWDTKGVSNLAGEIALAAGLVMWATTYPKIRRRFFEVFFYTHYLYIVFMLFFVLHVGISFSFIALPGFYIFLVDRFLRFLQSRENVRLLAARILPSDTMELTFSKNSKLVYSPTSIMFVNIPSISKLQWHPFTITSSSKLEPEKLSIVIKKEGKWSTKLHQRLSSSDQIDRLAVSVEGPYGPASADFLRHEALVMVCGGSGITPFISVIRDLIATSQKETCKIPKITLICAFKKSSEISMLDLVLPLSGLETELSSDINIKIEAFITRDNDAGDEAKAGKIKTLWFKPSLSDQSISSILGPNSWLWLGAILASSFLIFMIIIGIITRYYIYPIDHNTNKIYSLTSKTIIYILVISVSIMATCSAAMLWNKKKYGKVESKQVQNVDRPSPTSSPTSSWGYNSLREIESTPQESLVQRTNLHFGERPNLKKLLLDVEGSSVGVLVCGPKKMRQKVAEICSSGLAENLHFESISFSW
Function: Flavocytochrome that transfers electrons across the plasma membrane to reduce ferric iron chelates to form soluble ferrous iron in the rhizosphere. May be involved in the delivery of iron to developing pollen grains. Acts also as a copper-chelate reductase. Involved in glycine betaine-mediated chilling tolerance and reactive oxygen species accumulation. Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 81501 Sequence Length: 725 Domain: The C-terminus is probably located inside the membrane. Subcellular Location: Cell membrane EC: 1.16.1.7
F4I4K7
MAARGRLVVARGNRSFSSIIRKYSLKRETNKKVIKNVIKLLTMVILMGTVVIWIMMPTSTYKKIWLKSMRAKLGKSIYFGKPGVNLLVYMFPMILLASLGSIYLHLKKQTRVNQFNSRMDRKKIDKFGALKRPMLVKAGLGIVTVTEVMFLMMFMALLLWSLANYFYHTFVTITPQSLPTDGDNLWQARLDSIAVRLGLTGNICLGFLFYPVARGSSLLAAVGLTSESSTKYHIWLGNLVMTLFTSHGLCYCIYWISTNQVSQMLEWDRTGISHLAGEIALVAGLLMWATTFPAIRRRFFEVFFYTHYLYMVFMLFFVFHVGISYALISFPGFYIFMVDRFLRFLQSRNNVKLVSARVLPCETVELNFSKNPMLMYSPTSILFVNIPSISKLQWHPFTITSSSKLEPKKLSVMIKSQGKWSSKLHHMLASSNQIDHLAVSVEGPYGPASTDYLRHDSLVMVSGGSGITPFISIIRDLLYVSSTNAYKTPKITLICAFKNSSDLSMLNLILPNSTEISSFIDIQIKAFVTREKVSTCNMNIIKTLSFKPYVSDQPISPILGPNSWLWLATILSSSFMIFIIIIAIISRYHIYPIDQSSKEYTSAYTSLIYLLAISISVVATSTVAMLCNKKSYFKGLYQNVDALSPLMIESSPDQLLPEFTNIHYGERPNLNKLLVGLKGSSVGVLVCGPRKMREEVAKICSFGSAANLQFESISFNW
Function: Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 80934 Sequence Length: 717 Subcellular Location: Mitochondrion membrane EC: 1.16.1.7
Q9FLW2
MGNMRSLVKMLMVVLFLGWIFVWIMISTNRFQNIWTPKLAKYLKTTYFGPQGMNLVLLTVPMMFIAVLSCVYLHTQKQPSQTQSLYKCREWKVKGRMGRVMMVMNPLGIVTATELTFSLLFLALLVWALSNYLYLSYHVHLHNHDNANDMCRWQAKFRAFGLRIGYVGHYCWAFLFFPVTRASTILPLVGLTSESSIKYHIWLGHVSNFCFLVHTVVFLIYWAMVNKLMETFAWNATYVPNLAGTIAMVIGIAIWVTSLPSFRRKKFEIFFYTHHLYGLYIVFYAIHVGDSWFCMILPNIFLFFIDRYLRFLQSTKRSRLVSAKILPSDNLELTFAKTSGLHYTPTSILFLHVPSISKLQWHPFTITSSSNLEKDTLSVVIRKQGSWTQKLYTHLSSSIDSLEVSTEGPYGPNSFDVSRHDSLILVGGGSGVTPFISVIRELIFQSQNRSTKLPNVLLVCAFKNYHDLAFLDLIFPSDISVSDISKLNLRIEAYITREDKKPETTDDHKLLQTKWFKPQPLDSPISPVLGPNNFLWLGVVILSSFVMFLLLIGIVTRYYIYPVDHNTGSIYNFTYRVLWVMFLGCVCIFISSSIIFLWRKKENKEGDKDSKKQVQSVEFQTPTSSPGSWFHGHERELESVPYQSIVQATSVHFGSKPNLKKILFEAEGSEDVGVMVCGPKKMRHEVAKICSSGLAKNLHFEAISFNW
Function: Ferric chelate reductase probably involved in iron reduction in shoots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. May act in iron metabolism in reproductive organs . May function as root surface cupric chelate reductase and participate in the reduction of Cu(2+), for Cu(+) acquisition via Cu(+) transporters in response to copper deficiency . Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 81166 Sequence Length: 707 Subcellular Location: Cell membrane EC: 1.16.1.7
Q3KTM0
MDDHETPLLSKDLSSSSSSSSSSSSVVVSSLKWILKVVMSVIFVTWVVFLMMYPGSLGDQILTNWRAISSNTLFGLTGSMFLIFSGPILVIAILASLYLIISGEETVFTKKKITKFPRFRLWTFPVLVDGPFGVVSAAEFLGIMVFSVFFLWAIYAYTLRNLNVLDYFHVLPNNRSIFLLELTGLRFGMIGLLCMVFLFLPISRGSILLRLIDIPFEHATRYHVWLGHITMTFFSLHGLCYVVGWTIQGQLLELLFEWKATGIAVLPGVISLVAGLLMWVTSLHTVRKNYFELFFYTHQLYIVFVVFLALHVGDYLFSIVAGGIFLFILDRFLRFYQSRRTVDVISAKSLPCGTLELVLSKPPNMRYNALSFIFLQVKELSWLQWHPFSVSSSPLDGNHHVAVLIKVLGGWTAKLRDQLSTLYEAENQDQLISPESYPKITTCVEGPYGHESPYHLAYENLVLVAGGIGITPFFAILSDILHRKRDGKDCLPGKVLVVWAIKNSDELSLLSAIDIPSICHFFSKKLNLEIHIYVTRQSEPCLEDGMVHKVVHPSVKTPWTNGCSMSVLVGTGDNIWSGLYLIISTIGFIAMITLVDIFYINKYNITTWWYKGLLFVVCMVASVLIFGGLVVVFWHRWEHKTGEVEANGNDKVDLNGEETHNPSAAELKGLAIEEDVQNYTTIRYGTRPAFREIFESLNGKWGSVDVGVIVCGPATLQTTVAKEIRSHSIWRSANHPLFHFNSHSFDL
Function: Ferric chelate reductase involved in iron mobilization from the cytosol into the chloroplast. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. Might be involved iron homeostasis in trichomes. Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 84126 Sequence Length: 747 Subcellular Location: Plastid EC: 1.16.1.7
Q8VY13
MAKVLTLLVLRLLMNLLLIGWISLWIIKPTTIWIQSWRQAEDTARHTFFGYYGLNFAVFSFPPIALSIVGLIYLSLLPQHHHPTRGGRGAAITVSRPAIINSFIGIVSCFEILALLLFLLFLAWNFYARVSNDFKKLMPVKTMNLNLWQLKYYRVATRFGLLAEACLSLLLFPVLRGLSMFRLLNIEFAASVKYHVWFGTGLIFFSLVHGGSTLFIWTITHHIEEEIWKWQRTGRVYVAGLISLVTGLLMWITSLPQIRRKNFEVFYYTHHLYIVFLVAFLFHAGDRHFYWVLPGMFLFGLDKILRIVQSRSESCILSANLFSCKAIELVLPKDPMLNYAPSSFIFLNIPLVSRFQWHPFSIISSSSVDKHSLSIMMKCEGDWTNSVYNKIEEAANCENKINNIIVRVEGPYGPASVDFLRYDNLFLVAGGIGITPFLSILKELASKNRLKSPKRVQLVFAVRTFQDLNMLLPIASIIFNPIYNLNLKLKVFVTQEKKPSNGTTTLQEFLAQSQVQSIHLGTDEDYSRFPIRGPESFRWLATLVLITVLTFLGFLIGLSHFFIPSEHKNHSGVMKLAASGAMKTAKEKVPSWVPDLIIIVSYVIAISVGGFAATILQRRRKHKEAPRMSKEVVIKPEERNFTELKPIPITEEHEIHIGERPKLEEIMSEFEKNLRGWSSVGVLVCGPESVKEAVASMCRQWPQCFGVEDLRRSRMKMNLNFHSLNFNL
Function: Ferric chelate reductase probably involved in iron reduction in leaf veins for transport. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 83230 Sequence Length: 728 Subcellular Location: Mitochondrion membrane EC: 1.16.1.7
Q04800
MAINSSDKWTVIAICLILGILLAFILMFWLERFRVIIKSNAHKHDPSDKRQIWLEKYYLFVRQIYTYLVTHKVILTLIAVPVVFAISIPFIGMQTPASSHGKQTTQVSTGNWSKNAVAARLGFLACGLYVTSYFFSIKNNPFALLLISSHEKMNYVHRRLSQYAIMIGAIHGFAYIGLAAQGKRALLTARVTIIGYVILGLMVIMIVSSLPFFRRRFYEWFFVLHHMCSIGFLITIWLHHRRCVVYMKVCVAVYVFDRGCRMLRSFLNRSKFDVVLVEDDLIYMKGPRPKKSFFGLPWGAGNHMYINIPSLSYWQIHPFTIASVPSDDFIELFVAVRAGFTKRLAKKVSSKSLSDVSDINISDEKIEKNGDVGIEVMERHSLSQEDLVFESSAAKVSVLMDGPYGPVSNPYKDYSYLFLFAGGVGVSYILPIILDTIKKQSRTVHITFVWSARSSALLNIVHKSLCEAVRYTEMNINIFCHLTNSYPVEEVSSLNSQSARNYSLQYLNGRPDVNDYFKDFLHATGTQTAALASCGSDKLLRHLKSCVNTHSPSTVDLYQHYEEI
Function: Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64092 Sequence Length: 564 Subcellular Location: Cell membrane EC: 1.16.1.9
O94727
MILARDDKWTLGSIALIFVLLIGFALLFLLERFRVKEKSRTFKDCVNVYQCPSKGERVYLALRHWFIFLATHKAQMTLILSPLVMLVTIPFTGKETKNSIASYDWNLTGVAARLGYLSCGLFFVSYFFSLKNNPFCLMLFSSHEKMNYLHRWLSVYAVLISVLHGILFMIFSAQSYKPLLYDKISIYGYFITVVLFLMTVASLPSVRRKFFEWFFVLHHTCSVLIIFLIWLHHPRTIVYMKACIIIYAFDRGCRLFRSIWNRSNFRIYLLNEDMIYMVGRKPKRSFFALPWAAGSHVYINIPSLSYWQVHPFTLASAPFDDFIELFVAVHSGFTERLANRLYSMPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHTYEPEDLYLETTVFMDGPYGTTSNVFKEYSYVLLIAGGVGFSYTLPILRDLILKECNVTSITFIWSCRSLSLLKVASKSLNSLLHQSNVRLKIINHFTGSISCKESSEFSNQTTENSEMEFFDDRPDLDMYIQKFFDYVGYQTAALAACGSQSFLKRIKNSVNKSISSTTDIYQHYEEL
Function: Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Catalytic Activity: 2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH Location Topology: Multi-pass membrane protein Sequence Mass (Da): 65262 Sequence Length: 564 Subcellular Location: Cell membrane EC: 1.16.1.9
I1S165
MTIQSTANHQDGYLPAILCLHGAGTNATIFNLQARTIVRCLKHKFRFIFVNAPFESLPGPGVIPTFAEIRPYLRWHCDENAIQEFDVSPELVDNERRLVRSMISDKIEQEATGPSLGIVGVMAFSQGTRVATGLCLDPEFGSSIQFAIIIAGTFPALSLENPVSDSETTNLFSGINGNKHEQLQIPSVHVQGTMDPWGPESARLLKECWSADLAMVVKFHGAHQVPTSKKDAQAVAQAVLSCWDSAQT
Function: Thioesterase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism . Sequence Mass (Da): 27075 Sequence Length: 248 Pathway: Secondary metabolite biosynthesis. EC: 3.1.2.-
A0A0E0RXA9
MSVTRLSEPLQNILLQDLRNFYDRASRIATLSVSAIAAIKSAWTRGSPFAAATALYPTNEEGKYVIQAEGIRMEFTNYGGAVTNLWLNNSRGEEVDIVLGLDHARDYEDYPKNPYLNGAIGRYAGFMRGGRFDMDGESYQVATNAHNGSSTFNGGDRGWGRSILDIGSHTENSITFVLFDRSWNGFPGTAASCLTHTVTPYEWRVAFGVTPTKKPGPINMSQQAFFNLDGFKKKNLTGSVPVSDKTVRDHKLHLPLSGLRFETDALGLSTGDILGNPRGSEYDFWSASRRIGDVLEKPYMGICDRCQKRQYHNHNPSGAYDTIFQLGRSQPWNKEDVPAAILSSPESGISMKLYSDQEALHVHTWSQKEFPLKLKKGQGQGMVPQHGGISFEMQDWPDGLNHPEWRRESKTIWGMDGLYTAFSSYRFSVDKTEP
Function: Epimerase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism . Sequence Mass (Da): 48477 Sequence Length: 434 Pathway: Secondary metabolite biosynthesis. EC: 5.1.-.-
I1S163
MSVIGLWLVTVTATLSLFVWQLIFLLSIPKSIVVCLIAESLFFVAWFFYWTVIYPRYLTPFRHLPTPASRSILTGNQNGLFTENSWDVARRVSQTVPNSGLIRYYVALSNERILVTNTRALSDVLTNHSHDFGKSNLAKFALKRLTGNGLGFLEGNEHKVHRKNLMPAFTRKHVKELTPIFWDKAMEMVKGMEAEVRCGKDTSTQGTGIVEIHDWATRATLDIIGTAGFGYDFGTLHNPSNEIGQQYKKMFLEPSTAFNWLELLGNYIDFRFLMTLPVKKNRDLTAGSNFMREIAKKVIRERRHELFQRMTSQAGNMKNTKKDIITTALASDCFTDDQLVDHVMAFLVAGHESTATAFEWAMYELGHRPEMQKRVRDEVRTYLPSPSAGGVKNITFESVPYLQAICNEVLRLYPFLPFATRVAEKDTWVADQFVPKGTIVAYAAHISNRDSELWSGPALDAFDPERWMEPGKESSGGANSNYAMLTFSAGPKSCIGEAWTRAELPCLVGAMVGSFEIELVEGKQADGTVYPTVDFKMGKVLKSRDGVFVRLRRLEDW
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 62897 Sequence Length: 557 Pathway: Secondary metabolite biosynthesis. Subcellular Location: Membrane EC: 1.-.-.-
A0A0E0RXA7
MTNLPSHHTAIVGSEDGSLKVAEQVPLPRLENDMILVRNTAVALNPIDGKMVGNLASVGAVAGMDYVGTVVGIGPKVKTASEIQLGDRVCGAVQGMHSLTPSVGAFAQFVGATDIVTLKVPPSMTVEDAATLGSGVGTIGLALFRSLDVPGYPEAPATERIPVLVYGGSTATGTLAIQLLKLSGLIPITTCSPHNFDLVKSFGAEAVFDYRRPETPDEIRKFTRNSLKYVLDCISEPETMQFCYKCIGRTGGKYTALEPFPQFLHTRPTIQPDWVLGPTLLGKPIGWGPPFERVGDPDVREFAIKWFATAQRLLDQGKLQTHPVKLMEGGFEGILCGLEMLKKKQVSGQKLVYMIPQVA
Function: Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism . Sequence Mass (Da): 38517 Sequence Length: 359 Pathway: Secondary metabolite biosynthesis. EC: 1.-.-.-
Q556J4
MVSNKNLLPIIYIFFIILYFGDVAKSQYFPLDKGATCQKYRGDSPGIQLCDGFLSNPNSIYINSTSSQEAIQAQGNLVRQYINFYKSFESCKNPRTFALLCAFLFPECEKYTDPVSKVTYAYPILPCYNNCLNMTTSCQISTSRLSCATKYTFENISYSVFPKNTTTYQIDSLSYTNTCENTDLIANSQNTSIQQCFEPLVYHVSTDEIHDKSIGYIFPSTNTTCVVGCPAPLYYANQWRNIYRLSDVLSILSCILTLFLVITLGIINPKVSRFDKINVMLLSSIFLQAFSGALMTFNGTENTLCPEDGRFASYIDRMCVATGFLLHGSSLLVVQWWCVLSFEVWFTIFQVGKKQKDRFIYYLVASLIIAWIPPIVSISKNEYSGGPANPFCWLTTFNYRRFAFWLPMGIFLCLGGVFLILLMREIYVIVSGNVQSTKESRFKVLKMEAKPIISLIMYFSCLLYLFIYDQWINNHMHVYTDSIPSYALCLLTSTSTNDCLLKAPDITGLGYFIYSIRVFGVYAFIIYGISKKTLQIWKYNYFVVFIGQKIEQFTNATTTAKSSNSNNSSTTNNISVKASSNMEYETRQENENGDSQSVELDSNSDAL
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 68945 Sequence Length: 607 Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. Subcellular Location: Membrane
A4J0S6
MKKVPSDLEIAQAHEMIPIAEIAKNIGLGEDDIDLYGKYKAKISLDVLRKFNDRAMGKLIDITAITPTPLGEGKTVTTIGLCQGLGKIGKKVITTLRQPSMGPVFGIKGGAAGGGYSQVVPMEDINIHFTGDIHAVEAANNLLAAMIDTSILLGNPLNIDPMTVMWNRVLDTNDRALRDIVVGLGGKENGYPRQTSFDMAVASEVMAILALAENLHDLRQRLGRIIVAYTYDGKPVTAEDLKAAGAMTVIMKEALKPNLVQTLEGQACIMHAGPFANIAHGNNSVLADKIALNLADYVVTESGFGSDLGMEKFMDIKCRQSGLRPSCVVITCTIRALKMHGGLGNVVAGKPLPEELTRENLPALEKGCANLAHHIKVASYYGVPVVVSINRFTPDTDAEVDLVRKKALEAGALGAYPITVWAEGGEGAIELAEAVVAACEKTADFQLLYPDNLSIKEKIEVLATKVYNADGVVFEPLAERKIKQFEDLGLGHLPICMAKTHLSISHDPAMKGLPKNYIFPIRDIRASVGAGFLYPLAGAMRTMPGLGSKPAAHNVDIDEYGRTVGLF
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 60771 Sequence Length: 567 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
Q8RHF4
MTDIQIAQAAKKENIVEIAKKLGLTEDDIEQYGKYKAKVNLDVLQKNKRPNGKLILVTAITPTPAGEGKSTVTIGLTQALNKMGKLSAAAIREPSLGPVFGMKGGAAGGGYAQVVPMEDINLHFTGDMHAIGIAHNLISACIDNHINSGNALGIDVTKITWKRVVDMNDRALRNIVIGLGGKANGYPRQDSFQITVGSEIMAILCLSNSITELKEKIKNIVIGTSVTGKLIKVGDFHIEGAVAALLKDAIKPNLVQTLENTPVFIHGGPFANIAHGCNSILATKMALKLTDYVVTEAGFAADLGAEKFIDIKCRLGGLKPDCAVIVATVRALEHHGKGDLKAGLENLDKHIDNIKNKYKLPLVVAINKFITDTDEQINMIEKFCNERGAEVSLCEVWAKGGEGGIDLAEKVLKAIDNNKTEFDYFYDINLTIKEKIEKICKEIYGADGVIFAPATKKVFDVIEAEGLNKLPVCMSKTQKSISDNPALLGKPTGFKVTINDLRLAVGAGFVIAMAGDIIDMPGLPKKPSAEVIDIDENGVISGLF
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 58321 Sequence Length: 544 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
Q5V5Y2
MEPIWELVEPWGLGLDDLQYFGEYTAKVKQHAIERLREQAENREQNLVLVTGMTPTPKGEGKTVTTVGLGQTLNHVGEEAMIAIREPSLGPVFGVKGGAAGGGRSQVLPMEDINLHFTGDLHALTSAHNLIAAMLDAKISQGDDLNIDINNVSWPRAIDMNDRALRETVVGLGGKTGGTPREDSFILTAASELMAVLCLASDIGDLKERVSRIIVAYDEDGDPVTVEDIEATGPATMLLRDAIKPNVVQTIEGTPALVHGGPFANIAHGTNSLVADKTAFGMGDYLVTEAGFGSDLGAEKFMDVVCRKGDMTPNAVVLVASVRALKYHGLNQWPVDYDEIGEAGVEAVEAGFSNLDKHARNLQKFGVPVVVSVNRFPDDTDEEVQAVLDHCREDLGVRAAESNVFSDGSEGGVDLAENVIEATEESNEEDFRMLYDDDDSIKEKIHTVATEIYGADDVKYTGGALDDIEQMNDLDFDDYPVVMSKTFHSLSDDASQKGAPEGWELEISEVYPSAGAGFLVALTADALTMPGLPARPAAADMDIDGDGNISGLF
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 59251 Sequence Length: 553 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
A9B4H8
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVTAMTPTPLGEGKTATTIGLGMALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLEDSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQIQIRRVLDVNDRFLRSITIGQGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPITADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADYVVTEAGFAMDMGGEKFFDIKCRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLLQENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHPSEIEAVREIAMSAGAFDVAVSKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEAASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIAGDMMTMPGLSANPAAQQIDIDEHGNTVGLF
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 60778 Sequence Length: 570 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
Q1GA94
MVKSDIEIAQAAEELPITDVAAKLGLTSQDLEPYGYDKAKVNWQAIKRSEENGHLGKLILVTSISPTPAGEGKSTMTIGIGDAINNQLGKKTVIALREPSMGPVFGMKGGAAGGGYAQVIPMEDINLHFTGDMHALTSAIDNLSALVDNYIYQGNELGLDPEKIVIKRGLDVNDRTLRKVTIGQGSKFNGVERPASFQLTVGHELMAILCLSKDIADLKERIGKVLVGYTYEDEPVFVKDLGFQGAIAALLSTALKPNLVQTLEHTPAFVHGGPFANIAHGNNSILSTNLALHLSDYVLSEAGFGSDLGGQKFLDFVSTKLEKKPDAAVVVATVRALKYQAEKSTDHLKEENLDSLKEGFANLDRHMNNVRSYNIPVLVVINKFPTDTEAELDLLKSLIEEQGFPCEIVTAHDEGSKGAKAAAEKIVELADKSDYEIKRSYDLDDDLETKIEKVAKRIYHAADVEYTDKAKDQLVKLKKMGKDKLPVIIAKTQYSFTDNVKELGAPTGFTLHVKGLSLRNGAGFVVVSTGHILDMPGLPKHPAALDIDVDETGKISGLF
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 60503 Sequence Length: 559 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
Q9KLX7
MLPDIEICRATPLAPIDTIAQKAGLHANEYESHGQHKAKVSLHCLERLANKPKGKFILVTAITPTPLGEGKTVTTIGLAQGLAKLNHSVMACIRQPSMGPIFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAVTAAHNLAAAAIDARIYHEQRLGYADFERRTGMPALRIDPKQVIWKRVMDHNDRALRMVTVGRNEPGKNINGYEREDGFDISAASELMAILALASDLRDLRRRIGNVVLAYDLDGNPVTTEDLKVAGAMAVSMKEAIEPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADEIATRLADYTVTEGGFGSDMGFEKACNIKAKASGKTPDCAVIVATLRGLKANSGLYDLRPGQAVPDALFAPDSAALQAGFANLKWHIDNVNQYGVPAVVAINRFPQDCAEELEQLVKLIEALPNRVSVAISEGFAKGGEGTKLLAEKVVEQCQHPTKFTPLYDSGIPLDEKLKAVAVKGYGAAEIALSDKAAQQLAKLQTQGFDHLAVCLAKTPLSISTDPAIKGAPRDFIVPIRELRLCAGAEFVYALCGSVMTMPGLPEKPSFMALDIDQHGNIVGLS
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 62074 Sequence Length: 582 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
A1JMA3
MTPTLSSSADVLPSLSNMSSETNLLPIQQIAPQLGLSADDLIPYGHHMAKVDISALRPSGPQGKLILVSSITPTPLGEGKTVTTIGLSQGINRLGYRGVACIRQPSLGPVFGVKGGAAGGGAAQVLPMEKLNLHLTGDIHAISAAHNLAAAALDARLYHEQRLGAVFSQQTGMPLLNIDAQQILWPRVVDHNDRALRHIQVGVGGGTHGVERHDHVEITAASELMAILALSESLHDMRQRIGRIILAHSTSGQAITADDLGVAGAMTALMKETIHPTLMQTSEQTPVLIHAGPFANIAHGNSSVLADRLGLQLADYVVTEAGFGSDMGMEKFFNIKYRQSGITPSCVVLVATLRSLKANSGVFDIKPGQPLPAEILNTNIPLLSQGCANLKWHINNAKSYGLPVVVAVNCFPDDSPEELAFLADYALSAGAIACEISEAFAKGGAGTTALAQRVIDACAHASPPVLAYPDNASLEQKIEILAQRYGAREVTFTPQARQQLDSITAAGFGHLPLCIAKTPLSISADASLKNVPHDFVLPVTACAVSAGAGFVRIYAGDIMTMPGLGTQPAYYHIDIDDEGCIRGLS
Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate Sequence Mass (Da): 61470 Sequence Length: 585 Pathway: One-carbon metabolism; tetrahydrofolate interconversion. EC: 6.3.4.3
Q9FL59
MAAKDGAKSQEDYKLKDMKPELGERWPHGGQRGGTGWIGSERAASTYDLVEQMFYLYVRVVKAKDLPPNPVTSNCDPYVEVKIGNYKGKTKHFEKRTNPEWNQVFAFSKDKVQSSTVEVFVRDKEMVTRDEYIGKVVFDMREVPTRVPPDSPLAPQWYRLEDRRGESKKRGEVMVAVWLGTQADEAFPDAWHSDASSVQGEGVQSVRSKVYVSPKLWYLRVNVIEAQDVEPSDRSQPPQAFVKVQVGNQILKTKLCPNKTTNPMWNEDLVFVAAEPFEEQFFLTVENKVTPAKDEVMGRLISPLSVFEKRLDHRAVHSKWYNLEKFGFGALEGDKRHELKFSSRIHLRVCLEGGYHVMDESTLYISDVKPTARQLWKSPIGILEVGILSAQGLSPMKTKDGKATTDPYCVAKYGQKWVRTRTIIDSSSPKWNEQYTWEVYDPCTVITLGVFDNCHLGGSEKSNSGAKVDSRIGKVRIRLSTLEADRIYTHSYPLLVLQTKGLKKMGEVQLAVRFTCLSLAHMIYLYGHPLLPKMHYLHPFTVNQLDSLRYQAMSIVAARLSRAEPPLRKENVEYMLDVDSHMWSMRRSKANFFRIVSVFAGLIAMSKWLGDVCYWKNPLTTILFHVLFFILICYPELILPTTFLYMFLIGLWNFRFRPRHPAHMDTKVSWAEAASPDELDEEFDTFPTSKGQDVVKMRYDRLRSVAGRIQMVVGDIATQGERFQALLSWRDPRATCLFVIFCLVAAMILYVTPFKIIALAGGMFWMRHPKFRSKMPSAPSNFFRKLPSKADCML
Function: Involved in the export of FT from the phloem companion cells to the sieve elements through the plasmodesmata . Regulates flowering time under long days . May function as a signaling molecule by regulating the trafficking of other regulators . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 91003 Sequence Length: 794 Subcellular Location: Endoplasmic reticulum membrane
Q69T22
MTMTGGHHHDAHHEDFQLKDTNPLLGEQWPKGAAGPARPAVGGGIAGWLGLEKPSSTYDLVEQMFFLYVRVVKAKDLPPNPITGSPMDPYVEVKLGNYKGTTKHYDRRANPEWDQVFAFSKSRVQSNVLEVYLKDKEMLGRDDYVGRVVFDLAEVPTRVPPDSPLAPQWYRLEERRVGGGGDGGGLKVRGELMLAVWIGTQADEAFPEAWHSDAATVRGEGVASVRSKAYVSPKLWYLRVNVIEAQDVQPQARGRAPEVFVKAQVGNQILKTSVVAAPTLNPRWNEDLVFVVAEPFEEQLLLTVEDRVTPRKDDLLGRAALPLALFEKRLDHRPFVQSRWFDLEKFGIGGAIEGETRRELRFASRVHVRACLEGAYHVMDESTMYISDTRPTARQLWKPPVGVLEVGILGAAGLQPMKNRDGRGTTDAYCVAKYGQKWVRTRTMLGTFSPTWNEQYTWEVFDPCTVITIGVFDNNHLGNGNGNGNNAGGGGGGSPPARDARVGKIRIRLSTLETDRVYTHAYPLIVLQPSGVKKMGELRLAVRFTCLSLMNMVHLYTQPLLPRMHYLHPFTVTQLDALRYQAMGIVAARLGRAEPPLRREVVEYMLDVESHMWSMRRSKANFFRAVSLFSGAAAAARWFADVCHWKNVATTALVHVLLLILVWYPELILPTVFLYMFMIGLWNYRRRPRHPPHMDTKMSWAEAVHPDELDEEFDTFPTSRQQDVVYMRYDRLRSVAGRIQTVVGDMATQGERLQSLLGWRDPRATCLFVVFCLVAAVVLYVTPFRVVALVAGLYLLRHPRFRSRLPAVPSNFFRRLPSRADSML
Function: Involved in the export of the long day-specific flower-promoting signal (florigen) RFT1 from the phloem companion cells to sieve elements . Promotes flowering under long days through the transport of RFT1 from the leaves to the shoot apical meristem (SAM) . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 92948 Sequence Length: 824 Subcellular Location: Endoplasmic reticulum membrane
Q9C8H3
MQRPPPEDFSLKETKPHLGGGKVTGDKLTTTYDLVEQMQYLYVRVVKAKELPGKDLTGSCDPYVEVKLGNYRGTTRHFEKKSNPEWNQVFAFSKDRVQASYLEATVKDKDLVKDDLIGRVVFDLNEIPKRVPPDSPLAPQWYRLEDGKGQKVKGELMLAVWFGTQADEAFPEAWHSDAATVSGTDALANIRSKVYLSPKLWYLRVNVIEAQDLIPSDKGRYPEVFVKVIMGNQALRTRVSQSRSINPMWNEDLMFVVAEPFEEPLILSVEDRVAPNKDEVLGRCAVPLQYLDKRFDYRPVNSRWFNLEKHVIMEGGEKKEIKFASKIHMRICLEGGYHVLDESTHYSSDLRPTAKQLWKPNIGVLELGVLNATGLMPMKAKEGGRGTTDAYCVAKYGQKWIRTRTIIDSFTPRWNEQYTWEVFDPCTVVTVGVFDNCHLHGGDKNNGGGKDSRIGKVRIRLSTLEADRVYTHSYPLLVLHPSGVKKMGEIHLAVRFTCSSLLNMMYMYSMPLLPKMHYLHPLTVSQLDNLRHQATQIVSTRLTRAEPPLRKEVVEYMLDVGSHMWSMRRSKANFFRIMGVLSGIIAVGKWFEQICVWKNPITTVLIHILFIILVIYPELILPTIFLYLFLIGVWYYRWRPRHPPHMDTRLSHADSAHPDELDEEFDTFPTSRPSDIVRMRYDRLRSIAGRIQTVVGDLATQGERFQSLLSWRDPRATALFVLFCLIAAVILYITPFQVVAFAIGLYVLRHPRLRYKLPSVPLNFFRRLPARTDCML
Function: Required for proliferation and differentiation of shoot stem cells in the shoot apical meristem (SAM), thus determining the appropriate balance between the maintenance of shoot stem cells and their differentiation into other aboveground plant parts via the control of subcellular localization and intercellular trafficking of STM in the shoot apex . Prevents intracellular trafficking of STM to the plasma membrane in cells in the peripheral shoot meristem region thus facilitating STM recycling to the nucleus to maintain stem cells . May function as a signaling molecule by regulating the trafficking of other regulators . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 89154 Sequence Length: 776 Subcellular Location: Endoplasmic reticulum membrane
Q60EW9
MMQRPFRPEEYSLKETSPHLGGGAAGDKLTTTYDLVEQMQYLYVRVVKAKDLPSKDITGSCDPYVEVKLGNYKGTTRHFEKKTNPEWNQVFAFSKERIQSSVVEIIVKDKDFVKDDFIGRVLFDLNEVPKRVPPDSPLAPQWYRLEERNGHKVKGELMLAVWMGTQADEAFPEAWHSDAASIPGDGLASIRSKVYLTPKLWYLRVNVIEAQDLIPNDRTRFPDVYVKAMLGNQALRTRVSPSRTLNPMWNEDLMFVAAEPFEEHLILSVEDRIAPGKDDVLGRTIISLQHVPRRLDHKLLNSQWYNLEKHVIVDGEQKKETKFSSRIHLRICLEGGYHVLDESTHYSSDLRPTAKQLWKHSIGILELGILTAQGLLPMKTKDGRGTTDAYCVAKYGQKWVRTRTIIDSFTPKWNEQYTWEVYDPCTVITIGVFDNCHLNGGEKANGARDTRIGKVRIRLSTLETDRVYTHAYPLIVLTPAGVKKMGEVQLAVRFTCSSLLNMMHLYSQPLLPKMHYVHPLSVMQVDNLRRQATNIVSTRLSRAEPPLRKEIVEYMLDVDSHMWSMRKSKANFFRIMGVLSPLIAVAKWFDQICHWRNPLTTILIHILFVILVLYPELILPTIFLYLFLIGVWYYRWRPRQPPHMDTRLSHAESAHPDELDEEFDTFPTSRPPDIVRMRYDRLRSVAGRIQTVVGDLATQGERLQSLLSWRDPRATALFVTFCFVAAIVLYVTPFRVVVFLAGLYTLRHPRFRHKMPSVPLNFFRRLPARTDSML
Function: Promotes nuclear translocation of the transcription factor OSH1, which directly suppresses the auxin biosynthetic gene YUCCA4 during the late development of anthers . Reduction of auxin levels at late stage of anther development, after meiosis of microspore mother cells, is necessary for normal anther dehiscence and seed setting . Required for jasmonate (JA) biosynthetic genes expression and JA production in anthers . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 89345 Sequence Length: 774 Subcellular Location: Cell membrane
Q4WAW7
MPPAPPDQKPCHQLQPAPYRALSESILFGSVDEERWWHSTAPILSRLLISSNYDVDVQYKYLSLYRHLVLPALGPYPQRDPETGIIATQWRSGMVLTGLPIEFSNNVARALIRIGVDPVTADSGTAQDPFNTTRPKVYLETAARLLPGVDLTRFYEFETELVITKAEEAVLQANPDLFRSPWKSQILTAMDLQKSGTVLVKAYFYPQPKSAVTGRSTEDLLVNAIRKVDREGRFETQLANLQRYIERRRRGLHVPGVTADKPPATAADKAFDACSFFPHFLSTDLVEPGKSRVKFYASERHVNLQMVEDIWTFGGLRRDPDALRGLELLRHFWADIQMREGYYTMPRGFCELGKSSAGFEAPMMFHFHLDGSQSPFPDPQMYVCVFGMNSRKLVEGLTTFYRRVGWEEMASHYQGNFLANYPDEDFEKAAHLCAYVSFAYKNGGAYVTLYNHSFNPVGDVSFPN
Function: Brevianamide F prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities . The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA . Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B . FtmPT1/ftmB shows also tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus . The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively . The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B . Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties . In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable). Catalytic Activity: brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B Sequence Mass (Da): 52607 Sequence Length: 464 Pathway: Mycotoxin biosynthesis. EC: 2.5.1.106
Q4WAW5
MKPSHSDTPLMMPSVMKCGYLATAGLIGICTHLSYFRYGEHHLYPWRYVRFHLCLTMGVAALLYAKKPPQYTLCSMDLVKDVSLLMATYLVGLFASLLLYRTLFHPLRQIRGPWAAKISSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPEAVRMIYGPNSRCSKNTFYDNGHPMMSLHSYRDRIAHDQRRRVWSAGFGDRALRGYEQRMRVYRQKLFQRLEARAVAESAINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVDMLMHGMIGYRYLFPSWFFRLLATMPSLSSDWHKFIGFATDTMLRRVGEQVDVPDIFASLLAPLNGREPTEDERNMLMGDAMLIITAGSDTTATSLTSIVYELARHLDEVDKLRAELDPIEADSDGEYQHDTLAKLPHLNGFINETLRLHPPIPGVIPRKTPPEGIHVKDVFIPGNMTVFSPQWSMGRSEAAYIDPEIFNPERWYKHMDLVKDPSAFAPFSIGPYSCIGKPLALMNIRTTVARLIMSFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities . The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA . Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B . The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively . The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B . Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties . In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable). Catalytic Activity: O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64183 Sequence Length: 559 Pathway: Mycotoxin biosynthesis. Subcellular Location: Membrane EC: 1.14.14.118
Q9FIM2
MTSIELLSPLIHDKFRFSTCCSTSSLLYLHASSFFRDRSFGFRQNPNRFVSNSSIQLPQSVPGSINQERFNLWQGFSRKKSTSSSRTIVNCQEGDQKASSSEGEGKTNKDKGRKQGKNELWWSKGKKWQWKPIIQAQEIGVMLLQLGIVMFVVRLLRPGIPLPGSEPRTQTTFMSVPYSDFLSKVNNDEVQKVEVDGFHVLFKLKDDGNLQESETSSSSIKLSESSETMLRSVAPTKRVVYSTTRPRDIKTPYEKMLENNVEFGSPDKRSGGFFNSGLIVLFYIAVLAGLLHRFPVNFSQSTTGQLRTRKSGGPGGGKVSGDGETITFADVAGVDEAKEELEEIVEFLKNPDRYVRLGARPPRGVLLVGLPGTGKTLLAKAVAGESDVPFISCSASEFVELYVGMGASRVRDLFARAKKEAPSIIFIDEIDAVAKSRDGKFRMVSNDEREQTLNQLLTEMDGFDSSSAVIVLGATNRADVLDPALRRPGRFDRVVTVESPDKVGRESILKVHVSKKELPLGDDVNLASIASMTTGFTGADLANLVNEAALLAGRKSKMTVDKIDFIHAVERSIAGIEKKTARLKGSEKAVVARHEAGHAVVGTAVASLLSGQSRVEKLSILPRSGGALGFTYIPPTHEDRYLLFIDELHGRLVTLLGGRAAEEVVYSGRISTGALDDIRRATDMAYKAVAEYGLNEKIGPVSVATLSAGGIDDSGGSPWGRDQGHLVDLVQREVTNLLQSALDVALTVVRANPDVLEGLGAQLEDEEKVEGEELQKWLNRVVPSEELAVFIKGKQTALLPAQASSS
Cofactor: Binds 1 zinc ion per subunit. Function: Probable ATP-dependent zinc metallopeptidase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 87838 Sequence Length: 806 Subcellular Location: Plastid EC: 3.4.24.-
A2ZVG7
MSALQASLLLRPLPSPLPPRRRLPLPSSSASFPRAGHHRRLPLPLRALASEGPQPAPSPAPDPPPPELPAAPEAEEVVGTAAAEGGGKVEEEELEDLVEKGRAWVLALAAAVVAAARRFFDWVVSGDWMSWWPFWRPDRRLQRLIDDADANPADPAKQSALLHELNKFSPEDVIKRFEQRSHAVDSRGVAEYLRALILTNGIADYLPDEQSGRSASLPALLQELKQRVSGNEDKPFMNPGISEKQPLHVVMVDPKATGRSTRFAQEIFSTVLFTIAVGLMWVMGAAALQKYIGSLGGIGASGVGSSSSYSPKELNKDIMPEKNVKTFKDVKGCDDAKKELEEVVEYLKNPSKFTRLGGKLPKGILLTGSPGTGKTLLAKAIAGEAGVPFFYRAGSEFEEMFVGVGARRVRSLFQAAKKKAPCIVFIDEIDAVGSTRKQWEGHTKKTLHQLLVEMDGFEQNEGIIVMAATNLPDILDPALTRPGRFDRHIVVPNPDVRGRQEILELYLQDKPVSSDVDVNAIARSTPGFNGADLANLVNIAAIKAAVEGADKLAAAQLEFAKDRIIMGTERKSMFISDESKKACLFKLLYFILRELILTAYHESGHAIVALNTQGAHPIHKATILPRGSALGMVTQLPSQDETSISKKQLLARLDVCMGGRVAEELIFGEDNVTTGARNDLHTATELAQYMVSNCGMSDAIGPVHVKERPSVEMQSRIDAEVVKLLREAYGRVKRLLKKHEKQLHALANALLERETLTADEINKVVHPYQEEPQLSFQEEDFALT
Cofactor: Binds 1 zinc ion per subunit. Function: Probable ATP-dependent zinc metallopeptidase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85793 Sequence Length: 784 Subcellular Location: Mitochondrion membrane EC: 3.4.24.-
Q8VZI8
MIFSKLGSSLARSSRSKGFVYGGGVRSAVFNQGRLRAPQNLEAAVNQVDGGLGFLRRHFASFAARKGLEAGDLSRAFANPRLRRFFSSQTPKKKNYENYYPKDSKKAPKNEQKSESRDGSKKNENENAGDAFSNEYQNMLIPLMAIALILSTFSLGSREQQQISFQEFKNKLLEAGLVDHIDVSNKEVAKVYVRSSPKSQTTEEVVQGPGNGVPAKGRGGQYKYYFNIGSVESFEEKLEEAQEAIGVNSHDFVPVTYVSETIWYQELLRFAPTLLLVATLIFGARRMQGGLGGLGGPGGKAGRGIFNIGKAQITRADKNSKNKIYFKDVAGCEEAKQEIMEFVHFLQNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESAVPFLSISGSDFMEMFVGVGPSRVRNLFQEARQCAPSIIFIDEIDAIGRARGRGGFSGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFQIYLKKIKLDHEPSYYSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFDSAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGRISTGAQNDLEKVTKMTYAQVAVYGFSDKIGLLSFPQREDEFSKPYSNRTGAMIDEEVREWVGKAYKRTVELIEEHKEQVAQIAELLLEKEVLHQDDLTKVLGERPFKSGETTNYDRFKSGFEESEKESQKESVPVKPVEDDGIPPLEPQVVPT
Cofactor: Binds 1 zinc ion per subunit. Function: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system. Location Topology: Single-pass membrane protein Sequence Mass (Da): 89555 Sequence Length: 813 Subcellular Location: Mitochondrion inner membrane EC: 3.4.24.-
Q9FGM0
MSSSTLQASLFLRPPLHTSSFKLYPCLFSSSSLSFCPQSLSSFYRLSSVLHNSRFRPLPCSLRQDNVASDSDFIPKDSAFEVTDSAESNRLVSDTEVSELETNDRFVGGEETKSGGEEAEVSNGVTEGKEEDQKKSKFRIVVLMMALWAAIKRAIEKVMEWEWLSWWPFSRQEKRLEKLIAEADANPKDAALQGALLAELNKHIPEAVVQRFEQREHTVDSRGVAEYIRALVITNAISEYLPDEQTGKPSSLPALLQELKHRASGNMDESFVNPGISEKQPLHVTMVNPKVSNKSRFAQELVSTILFTVAVGLVWIMGAAALQKYIGSLGGIGTSGVGSSSSYSPKELNKEITPEKNVKTFKDVKGCDDAKQELEEVVEYLKNPSKFTRLGGKLPKGILLTGAPGTGKTLLAKAIAGEAGVPFFYRAGSEFEEMFVGVGARRVRSLFQAAKKKAPCIIFIDEIDAVGSTRKQWEGHTKKTLHQLLVEMDGFEQNEGIIVMAATNLPDILDPALTRPGRFDRHIVVPSPDVRGREEILELYLQGKPMSEDVDVKAIARGTPGFNGADLANLVNIAAIKAAVEGAEKLSSEQLEFAKDRIVMGTERKTMFVSEDSKKLTAYHESGHAIVALNTKGAHPIHKATIMPRGSALGMVTQLPSNDETSVSKRQLLARLDVCMGGRVAEELIFGLDHITTGASSDLSQATELAQYMVSSCGMSEAIGPVHIKERPSSDMQSRIDAEVVKLLREAYERVKSLLKRHEKQLHTLANALLEYETLTAEDIKRILLPKQEGEKFEEQQQEEGDLVLA
Cofactor: Binds 1 zinc ion per subunit. Function: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V. Involved in thermotolerance but not in high light stress resistance or in the assembly/stability of the complexes I and V of the mitochondrial oxidative phosphorylation system. Location Topology: Single-pass membrane protein Sequence Mass (Da): 88717 Sequence Length: 806 Subcellular Location: Mitochondrion inner membrane EC: 3.4.24.-
Q9SAJ3
MEIAISYKPNPLISSSTQLLKRSKSFGLVRFPAKYGLGATRKKQLFRVYASESSSGSSSNSDGGFSWVRLAQSIRLGAERIGEKIGESVKTEIGFDSEEASGRVNEYVARVKDSVHKGHHELTRFKNETVPSFIDWNKWEHWKDIRNWDGKRVAALFIYAFALLLSCQRVYVAIQAPRVERERRELTESFMEALIPEPSPGNIEKFKRNMWRKATPKGLKLKRFIEAPDGTLVHDSSYVGENAWDDDLETTEGSLKKIIGRNARIQTEAKKKLSQDLGVSGEIGDSVGNWRERLATWKEMLEREKLSEQLNSSAAKYVVEFDMKEVEKSLREDVIGRTSETEGTRALWISKRWWRYRPKLPYTYFLQKLDSSEVAAVVFTEDLKRLYVTMKEGFPLEYIVDIPLDPYLFETICNAGVEVDLLQKRQIHYFMKVFIALLPGILILWFIRESAMLLLITSKRFLYKKYNQLFDMAYAENFILPVGDVSETKSMYKEVVLGGDVWDLLDELMIYMGNPMQYYEKDVAFVRGVLLSGPPGTGKTLFARTLAKESGLPFVFASGAEFTDSEKSGAAKINEMFSIARRNAPAFVFVDEIDAIAGRHARKDPRRRATFEALIAQLDGEKEKTGIDRFSLRQAVIFICATNRPDELDLEFVRSGRIDRRLYIGLPDAKQRVQIFGVHSAGKNLAEDIDFGKLVFRTVGFSGADIRNLVNEAAIMSVRKGRSYIYQQDIVDVLDKQLLEGMGVLLTEEEQQKCEQSVSYEKKRLLAVHEAGHIVLAHLFPRFDWHAFSQLLPGGKETAVSVFYPREDMVDQGYTTFGYMKMQMVVAHGGRCAERVVFGDNVTDGGKDDLEKITKIAREMVISPQSARLGLTQLVKKIGMVDLPDNPDGELIKYRWDHPHVMPAEMSVEVSELFTRELTRYIEETEELAMNALRANRHILDLITRELLEKSRITGLEVEEKMKDLSPLMFEDFVKPFQINPDDEELLPHKDRVSYQPVDLRAAPLHRS
Cofactor: Binds 1 zinc ion per subunit. Function: Probable ATP-dependent zinc metallopeptidase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 115105 Sequence Length: 1008 Subcellular Location: Plastid EC: 3.4.24.-
A8ZNZ4
MPIETEPNRTRKNFEPKRFGGSLFILFTLLLFLNLFVLRGPRFPITAYSDFITQVEAGQVERVEVRPDRIRYILKSDQYGFNEGTETAAVFDTVPVGIDLELPKFLREHDVQYFAPPPSSLSWLPTLLGWVVPPLIFFGIWSWLINRNQGAGPAALTVGQSKARIYSEGSTGVTFDDVAGVEEAKTELLEIVDFLAHADKYTRLGAKIPKGVLLVGPPGTGKTLLAKAIAGEAKVPFFSISGSEFIELFVGIGAARVRDLFEQAKQQAPCIVFIDELDALGKARGGPGGFTGGNDEREQTLNQLLSEMDGFDPNVGVILLAATNRPEVLDPALLRPGRFDRQIVVDRPDKMGREAILKVHVRGVKLAEDINLTKLAVRTPGFSGADLANLVNEAALLAARQSRDAVVMSDFNEAIERVVAGLEKKSRVLNDLEKKTVAYHEVGHAIVGSLMPGAGTVEKISVIPRGIGALGYTLQLPEEDRFLITASELRGRIATLLGGRSAEELIFGVVSTGASDDIQKATDLAERYVTLYGMSDELGPIAYEKAQQQFLEGVPNPRRTVGPQVVEAIDQAVKDVVDGAHHMALSILSINQDMLQLTASHLLEKEVLESQELHSLLSQPQFPPDMDEWLQTGKLPQGKELIQTTLNSHQLIGIN
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 71566 Sequence Length: 655 Subcellular Location: Cellular thylakoid membrane EC: 3.4.24.-
A9NE17
MNKQQKPKRSPLRPDYLVIVIIILLAIGMYFFFTEMMAPKVKQFDEFEFIAAIESGQIATVRSEYVGGDNFNLWEVTGTFTTGNAPEGVGSYVIILYGDRLNNIQDIIITYNELNPSTPITVSFVPHVSVDFWNIISTLLLIAAPIVLVVIMFRSMSSQSNKAQDFTKNRAKLSQGRKVKFSDIAGADEEKAEMAELIDFLKNPKKYADMGARVPKGVLLVGQPGTGKTLLAKAVAGEAQVPFFSISGSDFVELYVGVGASRVRDLFKVAKQSAPCIIFIDEIDAVGRQRGAGMGGGNDEREQTLNQLLVEMDGFSANLGIIIMAATNRPDVLDPALLRPGRFDRQITMQVPDQKSREEILKVHARSKKLDPTIKFSEVAMRIPGFTGADIENLLNEAALLAARESRTVISMQDIDEAADRVTMGPAKKSRKYSPNEKKMVAYHEAGHAVIGLKVNLASTVQKVTIVPRGRAGGYALYTPVEEKFNYAKSELLAMITSALGGRVAEEIMFDDVTTGAYDDFKRATKLARSMVTEYGMSDLGPIQYESDSGNVFLGRDYLKDKNFSDAVALEIDREVRAIITECYEHARKVINENKNLLDNIAKYLIAVETLTKTDIDEIAATGQLQWWDNREVEEDSKKSE
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 70955 Sequence Length: 641 Subcellular Location: Cell membrane EC: 3.4.24.-
A0LR74
MSREVTSGLPQDKPTGSAPPPPPPWRRWLLPIGLLVSLVLLFTFPMRPSSGKTLTYSEFLTALHHHDIKTITIHSDGEASGQFADGRPYSTTIPIGLAGSQLLNELENNGVQISARPPGPSLASQVLAGVLSFLPFLLLLGLFAYSGRRAGAGFLAGLPGIGRARAKIFTTERPQTRFSDVAGYDGVKAEIAEVVDFLRSPERYRRAGAAIPRGVLMVGPPGTGKTLMARAVAGEAGVPFLSVTGSSFVEMFVGVGASRVRDLFEEARKHAPCIVFVDEIDAIGQRRAGAGTIVANDEREQTLNQLLAEMDGFEPAQGVVVLAATNRPEVLDPALLRPGRFDRQVTVPLPSQADRAAILRVHCRNKRLAPDVDLDAVARATPGFSGAELANLVNEAAIAAARAGRRDLTAEDFRYARDRIILGRREDSNVLLPSERHAVAVHEAGHAVVAACSENADPVERVTILPAGRALGVTFQLPLAERHLYSESYLRDSLAVRLGGRAAELEILGEASTGAVNDLSSATELALRMVREYGLSPRLGPVSYPVGGSMYLPGGQELTPRPYAEATQQRIDQEVADLLRDAEERARDIIRRNRQAVDELASLLLEQESVDGAVVYQLVGRPVPTPEEHREAAARHVRRPGIAAATGASMAGGSEPRTAASSDDLL
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 71287 Sequence Length: 666 Subcellular Location: Cell membrane EC: 3.4.24.-
C1F8X6
MNSTVKTIVFWVFILACCILLWQVFQRSSNTGKEQEISFSQFLNDAQQGQIHDVTVVGGEVHGHFRSANAAFHVEVPTNYPQLYDILNKNHVAVTVKDNSGSPWWSILIQFSPVLVLVALWFFMIRQMQSGGNKALSFGKSRARLLSMQQKKVTFKDVAGVDEAKEELKEIIEFLREAQKFQKLGGRIPKGVLLVGPPGTGKTLLARAVAGEANVPFFSISGSDFVEMFVGVGASRVRDLFEQGKKNAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFEANDGVILVAATNRPDVLDPALLRPGRFDRRVVVGRPDVRGREEVLRVHAKKVPLAEDVDLRVLARGTPGFSGADLANMVNEGALSAARANRKVVTMQDFESAKDKVLMGAERKSMLLTDEEKRVTAYHESGHAIVAAMRKHADPLHKVTIIPRGMALGVTMQLPEEDKHTVTKDYLETQLAILMGGRIAEEIFLHQMTTGAGNDIERATEMARKMVCEYGMSRLGPLTYGKKEEQIFLGREIAQHRDFSEETARQIDAEVRSLVDEAYRASYQLLNDNQPIMHKMAAALLERETIDANDIRMIIEGKDLPPLKPSGGSGTATTDDVQQVLKPSSDRGAGGLPEGSPSPA
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 70328 Sequence Length: 639 Subcellular Location: Cell inner membrane EC: 3.4.24.-
C7M0M0
MMPSSQRPSPRGSRQSPSPDQRGRIAFAILATLVVAVLLLTLFSHAPSGQPLGYSTFIHDVQAKQVRTAVLNNTTGQITGSLTNGTAYSVTGPLPYTSSELSTLSKAHVQVSYITPGPGIASTIIEYVIFFGIFIGIWVYLTRRTQGSVNGIMSVGRSRAKTYTTERPKTTFDDVAGYQGVKGEVKEVVDFLRDPSRFSQLGARIPKGILLVGPPGTGKTLLARAVAGEAGVPFMSVSGSDFMEMFVGVGAARVRDLFQTARRQSPSIIFIDEIDSIGRKRGTGLGGGHDEREQTLNQMLSEMDGFDPAEGIVVMAATNRPDILDPALLRPGRFDRQIVVPLPDLPERLAILQVHTRGKRLAPDVDLEVMAKGTPGMSGADLANLVNEAALNAVRRGATDIAMADFDSARDRIIMGQRREATILSDEEKERVAFHEGGHAVLAYVLDYSDPVHKVTILPTGMALGVTQQLPERDRHLYPREYIEDTLVVRMGGRVAELLVYGDLSTGAANDLQGNTELARRMVREWGMSERLGPMAWGSQNVVFLGEDLLHSAEYSDRTARLVDEEVERILREQEERATELLRQHLPGLIAVAHALLERETISGEEVGRLVDEAAGHPIHPDGKRVLPIAKLPEYAELEQFTVTNGNNHAASHDDTDPVS
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 71888 Sequence Length: 660 Subcellular Location: Cell membrane EC: 3.4.24.-
B2UMY1
MPPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQYKAGRVVLNDPKAPVEVVLSENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKPLLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNRLALEGRIAGGKDGIILAEDGNQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGSWGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRDLGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGSDFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQRGYGMGGGNDEREQTLNALLVEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVKMAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERRSLAINERGRRITAVHEAGHAICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLRSEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLARRMVCEFGMSEKLGLIEYGEHQGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALMEFETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAEERKMEEELEQAERAPFSYNPVDEFGKDGGEKK
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 89455 Sequence Length: 812 Subcellular Location: Cell membrane EC: 3.4.24.-
P94304
MNRIFRNTIFYLLIFLVIVGIVSVFNSDQTETENVSFNEFAERLENGQVQELSVKPERQVYLVRGQFNDQAEDEFFQTYALRSEQTAELLFNAEDPTGTPFNLEIEPADETSGWVQFFTGIIPFIIIFILFFFLLSQAQGGGSRVMNFGKSKAKMVNEDKKKAKFKDVAGADEEKQELVEVVEFLKDPRKFSAIGARIPKGVLLVGPPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQIQVNRPDVNGREEVLKVHARNKPLNDDVNLKTIATRTPGFSGADLENLLNEAALVAARHDHTKISMIHIEEAIDRVIAGPAKKSRVISPKEKKIVAWHEAGHTVVGVKLENADMVHKVTIVPRGMAGGYAVMLPKEDRYFMTQPELLDKIIGLLGGRVAEEVTFGEVSTGAHNDFQRATGIARKMVTEYGMSEKLGPMQFISGSGGQVFLGRDIQNEQNYSDAIAHEIDLEVQRIIKECYARCKQILLENKDSLDLVAKTLLDMETLDAEQIKSLVHEGKLPDDHHLNAHLEKEKASESDVKVNINSKKEETPQVEAEQPQEPNTDEPIEKDPSVEDNRSFEDDTNKKE
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 75446 Sequence Length: 679 Subcellular Location: Cell membrane EC: 3.4.24.-
B8J992
MSADEKKGHGQRSERGRGPGGPGTQPRIPLASPAAWLVLIALAIFLFRAFQDVGVRRIPYSQFKEMVRQSAFERVVIGPDWVRGVPKPVEAGAAQGGGAQPQQQAQGEGERNGQALPYVATRIPGGGDDLVQAVEKAGVPYDAVAGGGMGDLFWVWIAPIAIGLLFWAWVMRRMSGQLGQGPPGVMAFGKSRARIHMEPDTGVTFQDAAGIDEAVEELQEIVEFLKTPEKYRRLGGRIPKGVLLVGPPGTGKTLLARATAGEAGVPFFSLSGSEFVEMFVGVGAARVRDLFAQATQKAPCIVFIDELDALGKSRNAGIMGGHDEREQTLNQLLAEMDGFDARAGLIIMGATNRPEILDPALLRPGRFDRQVLVDRPDKRGREQILRIHARNVKLGPDVDLRSVAARTPGFAGADLANVVNEAALLAARRNKNHVTRAEFEEAIERVVAGLEKKSRRINEREKEIVAFHEAGHALVSWMLPFADRVSKVSIIPRGLGALGYTLQLPLEDRYLLTRSELRDRMAGLMGGRVAEEEVFGEPSTGASNDLQHATAVARMMVRDYGMSPALGPVSLGDQNGPSFLGVKGFETRSYSDHTALAVDREVQALVEEAQDRARTVVREHRERLEALAARLLTIEVVEEDEITRLWGPKVVRPGTIEGRGHEESPPETPNRPVAASADASAGFGRSGPQPPQALARHAGGDPDPES
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 76249 Sequence Length: 706 Subcellular Location: Cell inner membrane EC: 3.4.24.-
O67077
MNALKNFFIWAIIIGAAIVAFNLFEGKREFTTKVSLNEVVKLVEEGKVSYAEVRGNTAIIQTKDGQKLEVTLPPNTNLVDKMVEKGVRVEVANPEPPGGWLVNVFLSWLPILFFIGIWIFLLRQMSGGGNVNRAFNFGKSRAKVYIEEKPKVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDEIDAVGRARGAIPVGGGHDEREQTLNQLLVEMDGFDTSDGIIVIAATNRPDILDPALLRPGRFDRQIFIPKPDVRGRYEILKVHARNKKLAKDVDLEFVARATPGFTGADLENLLNEAALLAARKGKEEITMEEIEEALDRITMGLERKGMTISPKEKEKIAIHEAGHALMGLVSDDDDKVHKISIIPRGMALGVTQQLPIEDKHIYDKKDLYNKILVLLGGRAAEEVFFGKDGITTGAENDLQRATDLAYRMVSMWGMSDKVGPIAIRRVANPFLGGMTTAVDTSPDLLREIDEEVKRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCEEFVEVFKLYGIELKDKCKKEELFDKDRKSEENKELKSEEVKEEVV
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 70686 Sequence Length: 634 Subcellular Location: Cell inner membrane EC: 3.4.24.-
Q2NIN5
MSFFDKIFKKFHMGVLYFAVILIGATFIYCYFTKHEKKDNNTFDALAQKNEIEKIQYNPIFANSAFCDIVVTTTDGRVIDFFNIPYDKVFEKKPNGKYKYNTYSVDPRPWNGYEHVFWVFRQCLTMLFFYCFFLFFADTIKQMGQEILASTSGKKGAKSRKVIINHKRFTFSDVAGADEEKEEMSELIDFLKNPRKYAAMGARIPKGVLLYGPPGTGKTLLAKAVAGEAGVPFFAASGSDFDEVYVGVGASRVRDLFKEAQLAAPCIVFIDEIEAVARKRGSNIGGSNGSEQTLNQLLVEMDGFNQKMGVIVIAATNQPEVLDSAILRPGRFDRHFNITLPNVKDREAILKLHASNKKLSEEISLEELAKQTPGFSGAQLEGTLNEAALLAARRNATFINKKDISEALDRILIGPTKKSKKYNDKEKRMVAYHEAGHAVIGIKIPFAQIVQKITIIPRGNAGGYNLMLPQEETFFSSKKALLAQITSFLGGRVAEELMFDDVSNGAYNDFKHATQIAKLMVTKYGMSDLGPVQYSGNTFQNDFSDPKGLEIDQQIQKIIANCYQQAKQIIQENQDLLDTIAKYLLEIETLNKRDIDEIVATGKIAWWEKEKEETNAPTQTTSQMSSNNETTNTDKTPLNDELEITTNLDNQESNESNPNNNEKASPEVLSTDSEQT
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 75765 Sequence Length: 676 Subcellular Location: Cell membrane EC: 3.4.24.-
P37476
MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNLDDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEPAQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKFKDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVIGREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDARDIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQAGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIARRMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYERAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNILTKTEEKKDDTKE
Cofactor: Binds 1 zinc ion per subunit. Function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 70937 Sequence Length: 637 Subcellular Location: Cell membrane EC: 3.4.24.-
O83964
MERSPLPRIIALTFGTLLFVSAVLLTLSTFLPLFTLHRASHWFFVPGTLLYETYAFSSLLVPLLLLHTALLLFVGGRSLRAESALVAFPLLFITAVCGEHGLYALRRALAARSISPSTRGGIDIVCVLCLLALLGAELYAALIYGERCYVWFHARIPRDFIADGFQDPSFPPSTADHPDTVSPPPAPSCATADVQTPEASAPPEGQFSTEVPLQGGEFLISEAEVQPATQVAACGGVSTPTALAPSVPSQAPFPLLPAPGLIQSNLPSDVHAPASPGSLPSVIPAQAPCVMALSPISAPSVAPAETLIPAQDDEQGPPRPIPASAAPLRHPCRGYQVPYDLLDQYSEDTYEGIDELTKNLALLLEETFSEFNIRVEITGIKKGPVVTMFELLPPPGIKLSKITNLQDNVALKLAASSVRIVAPIPGKHAIGVEVPNKKRSLVTFKELLHTRTAGSNRMAIPVILGKDVTGEPQVIDLAQTPHLLIAGATGSGKSVCVNALILSILYHKCPDETKLLLIDPKIVELKLYNDIAHLLTPVITEPKRALQALQYILCEMERRYALLEQLECRDIKTYNKKIQEKSIATQPLPFIVIIIDEFADLMVASGKELETSVARLCAMSRAVGIHLVLATQRPSIDVITGLIKANIPSRIAFMVSSKMDSRIILDEMGAEKLLGRGDMLYMNPSQSFPTRIQGAYVSERELARVIAHVRAWGTPEYLDEEIFFDDDDASISGNFVDESDPLYEQAVQVVQYAGKASTSYVQRKLKIGYNRAARLIEEMEARGVVGPPNGSKPRDVLRS
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 86606 Sequence Length: 799 Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity). Subcellular Location: Cell inner membrane
Q83MS8
MSAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGNWLSGIVSEYTVAAFFGGFSIVLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAFLHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLAKTVCIIFIVLSVSVISKTPISKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSGTSLTGSPVSEYHGESSDYALPSLDILNSYPPAKHDDAENEKVITALSGVLRQFSVNARFSGFSRGPTVTQYELELGEGVKVERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKKRELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTMPHLLVAGATGSGKSSFVNSMITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRYDDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVRITQLARASGIHIVLATQRPSVNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVGQGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHPDYYVLEVQNQGNIDSHIGDDMPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVTPQDLDSTLARISASVSDSKLD
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 80484 Sequence Length: 741 Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity). Subcellular Location: Cell membrane
Q84I33
MFKENKNKVETIIKTSEEAPSSRLNGSQRLKESGLILAFLFSIFLAVALFSFNPADPSWSQTAWGTDIHNAGGLVGAWLADTLFFVFGSLAYPLPFITAFAAWVLLRKRDEGDEIDFTLWGTRLLGLTIVLLTSCGLADINFDDIWYFSSGGVIGDVLTSLALPTLNILGTTLVLLFLWGAGITLLTGISWLRIVEWIGERSIAAFVGLFNRLRGEKAERVKPALVKPELPVEELEPTFSASMDTEIDEPAPSLRRFNIHMPEERDVPDIHFEPQVEPKVELKPEPPRQREPAPHFSRVAAQNTQVEPVSSARTQQWDATIEELEQQARLVDDYAVEDDAVPSVLTSSTLSDVEDSILTTAISVDEEEESLSENFNHSFNIEVEDEEVEPSIANLHWSDDEDELEETPSVMVSPAIESDWEDEDEPDDRDVAAFQNIVSQAQANAAAQQNPFLVQKAVNLPKPTEPMPTLELLYHPEKRENFIDREALEEIARLVESKLADYKIQAQVVDIFPGPVITRFELDLAPGVKVSRISSLSMDLARSLSAMAVRVVEVIPGKPYVGLELPNMSRQTVYLSDVIASPQFKESKSPTTVVLGQDIAGDAVVADLSKMPHVLVAGTTGSGKSVGVNVMILSMLYKASPEDVRFIMIDPKMLELSVYEGIPHLLAEVVTDMKDASNALRWCVGEMERRYKLMSVLGVRNIKGFNDKLRMAAEAGHPIYDPLWKDGDSMESEPPLLEKLPYIVVVVDEFADLMMVVGKKVEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFTVSTKTDSRTILDQSGAESLLGMGDMLYLPAGSSHTIRVHGAFASDDDVHAVVNNWKARGKPNYISEIIQGDHGPEALLPGEQSESDEELDPLFDQVVEHVVETRRGSVSGVQRRFKIGYNRAARIVEQLEAQGIVSAPGHNGNRDVLAPAPIRD
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 105888 Sequence Length: 960 Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity). Subcellular Location: Cell inner membrane
Q8D8M2
MFKENAKKVQTIIKTSEEAQSSRLNGFQRLKECCLILGVLTSAFLSIALLTFSPADPSWSQTSWGGDISNAGGQFGAWVADTLFFTFGLLAYLLPVLLVIVTWVFFRTRDEDEHIDLMLWGTRLLGLAILILTSCGLADINFDDIWYFSSGGVLGDVLNSLALPTLNLLGTTLVLLFAWGAGFTLLTGISWLSIVEWIGSLFLDVCQWALNRLRGEKTEVIAPELQPIALSDDEPKAQPQIEAQQDEIVEEERIPDPLPVEPVVQMRREYPIHMPQTVSYQTVSDELDELEDNSFERAKKLNATIEELEQEALSVNDLPDDTMSTERARYNVADIAQVSAEHSQTTQVEHAQDFSVDVEEFDHVISLSELDKISEEIDEPVMVGFAEEAPLHHNEAQRSAMASSAEPMFSHLGVEQTTQHTTQEEIVDLPVADSVGDVNPEMEDYVEEDEDQDQDVVAFQNMVSKAQQNMAATQNPFLMKQDTSLPVPKEPLPTLELLYHPEKRENFIDKEALEQVARLVESKLADYKITAEVVGIFPGPVITRFELDLAPGVKVSRISSLSMDLARSLSAMAVRVVEVIPGKPYVGLELPNMSRQTVYLSDVIDSPQFQNATSPTTVVLGQDIAGEALVADLAKMPHVLVAGTTGSGKSVGVNVMILSMLYKASPEDVRFIMIDPKMLELSVYEGIPHLLAEVVTDMKDASNALRWCVGEMERRYKLMSVMGVRNIKGFNEKLKMAADAGHPIHDPFWQEGDSMDTEPPLLEKLPYIVVVVDEFADLMMVVGKKVEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFTVSTKTDSRTILDQGGAESLLGMGDMLYLPPGSSHTIRVHGAFASDDDVHAVVNNWKARGKPNYIDEIISGEQGPESLLPGEQMESDEDLDPLFDQVVEHVVQSRRGSVSGVQRRFKIGYNRAARIVEQLEAQGIVSAPGHNGNREVLAPAPPRE
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 108746 Sequence Length: 985 Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity). Subcellular Location: Cell inner membrane
Q8P993
MAKQVPERSKPAEGKSSSRKPAAADTPRRQKLWRDLALIAVAPLLLYLLASLFTYSAADPGWSQTGSVVAPVHNMGGRVGAWIADVLLQLFGYVAFLLPVVLGAVAWIALFGMDKEGQAEADLGPALRLVGMVGFLIASTGFLHLRLFNGDVAGAGGILGRLVSNSLSAGFGALGANLFVVVLLLVSITLATGLSWFVVMERIGKWVLALGPLLQRKSHQATEWQQTRVMREEREEVRKVDAVKQAKREPVKIEPPPAPVVEKSERAKRDTQIPMFQGVSTDGSDLPPLALLDDPKPQAKGYSEETLETLSRQIEFKLKDFRIEAQVVGAYPGPVITRFEIEPAPGVKVSQISSLDKDIARGLSVKSVRVVDVIPGKSVVGLEIPNVTREMIFLSELLRSKEYDKSASPLTLALGKDIAGRPTVADLARMPHLLVAGTTGSGKSVAVNAMVLSLLFKASHKELRMLMIDPKMLELSVYQGIPHLLAPVVTDMKEAANGLRWCVAEMERRYKLMSAVGVRNLAGFNKKVKDAEDAGQPMMDPLFKPNPELGEAPRPLETLPFIVIFIDEFADMMMIVGKKVEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFQVSSKIDSRTILDQSGAEALLGNGDMLYLPPGTALPDRVHGAFVSDEEVHRVVEHLKASGPVAYVDGVLDEVQTMGDGTVVGATGLPESSGGGGDESDPLYDEALRIVTETRRASISGVQRRLKIGYNRAARLIEAMEAAGVVSPPEHNGDRTVLAPPPPK
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 84638 Sequence Length: 785 Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity). Subcellular Location: Cell inner membrane
Q81WC4
MSNLAVKYKQQAQEEVQIQTPPQQMVQPKAKAKITRIEKLLYVAFIGFLLYACVAFIGNKAGLYQVNVEAATIEQKIVQQQKENQELQAEVEKLSRYERIAEVAKKHGLEINANNVKGLK
Function: Essential cell division protein. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 13601 Sequence Length: 120 Subcellular Location: Cell membrane
Q07867
MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAAVLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKKNGLNLKDKKVKNIQE
Function: Essential cell division protein that may play a structural role. Probably involved in the regulation of the timing of cell division. Also required for sporulation. PTM: Cleaved by RasP. Cleavage is important for turnover and function of FtsL. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 13073 Sequence Length: 117 Domain: The cytoplasmic region is involved in protein stability. Subcellular Location: Cell membrane
Q7VUP7
MGRISLIVAALLMLSAISLVTSRYQSRQLFIELGRSQAEARDLDTNWRRLQLERAELARNARIDRAARDDLKMIPIVPDRTLYMNQPAGGAQ
Function: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 10438 Sequence Length: 92 Subcellular Location: Cell inner membrane