ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q89WW0
MTAFHSVAVIGAGAWGTALAMVAARAGRSVTLWARNAEHATRIASTRDNPRLPGVRLAPDIVVTSELALAARADMLLIATPAQHLRGAVNMLASHIARPTPVVACAKGIEHGTHKFMTEVIAEAALHAQPAILSGPSFADDVARGLPTAVTLAAKEEELASSLVQALGSPTFRPYHSTDVRGVEIGGAAKNVLAIAAGIVVGRNLGASALAALTTRGFSELARLGRACGARPETLSGLSGLGDLLLSCSTAQSRNFALGIALGRGEAAPAGKLAEGAFTAPVLVELAAARNVDMPVSQAVAAILDNKLTIDAAIEGLLTRPFKAEE
Catalytic Activity: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 33282 Sequence Length: 326 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.94
C0QYQ8
MINVGIIGAGGWGLALANIFSEKHNVKVWVHSESSYKLLSTSYRNDNYLENIQLNKSIKFTTDVGEAVNDSEIVIIVTPSFAFADACINIEPYISNDQILVSATKGLDRKTGKTMSEVARSIISGDLSILTLSGPSHAEEAAKGVPTAVVVGGEKGVSEYVRDTLTVPPKFRIYNSTDQKGVEIGGALKNIIAIAGGIVDGLKLGDNTKAALITRGLHEIVRFALSKGARIDTMYGLSGIGDLIVTCSSGLSRNNRLGRELAKGKKYQDVIAENHGQVAEGVYATTAAYEYAQKNNIYMPITEAIYNILFNDANIQDTLTELMSKDAKSEGFF
Catalytic Activity: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 35835 Sequence Length: 333 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.94
Q5ZT56
MNKKTIAMLGAGSWGTAVAIHLAKIGHKTLLWSHNPQHVALMAEQHSNPAYLPGIPFPENLIPSDNLIECVQSADYVIIAVPSHAFAEIINKIPKPTQGLAWLTKGVDPASHELLSQLVASRFGVDFPIAVISGPSFAKEVARFLPTALTLASNNTNYQKKMHQLFHHDNIRVYLSDDLIGVQLCGAVKNILAIACGISDGLGYGANAKAALITRGLAEMTRLGLSMGARQDTFLGLAGVGDLVLTCTDDQSRNRRFGLLLGREVPIPEAEHQIGQVVEGKHNAAQICAIANKNKVEMPICEQINALLHGIVHAQEAVNNLMSRPAKEE
Catalytic Activity: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 35410 Sequence Length: 329 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.94
P90551
MSTKQHSAKDELLYLNKAVVFGSGAFGTALAMVLSKKCREVCVWHMNEEEVRLVNEKRENVLFLKGVQLASNITFTSDVEKAYNGAEIILFVIPTQFLRGFFEKSGGNLIAYAKEKQVPVLVCTKGIERSTLKFPAEIIGEFLPSPLLSVLAGPSFAIEVATGVFTCVSIASADINVARRLQRIMSTGDRSFVCWATTDTVGCEVASAVKNVLAIGSGVANGLGMGLNARAALIMRGLLEIRDLTAALGGDGSAVFGLAGLGDLQLTCSSELSRNFTVGKKLGKGLPIEEIQRTSKAVAEGVATADPLMRLAKQLKVKMPLCHQIYEIVYKKKNPRDALADLLSCGLQDEGLPPLFKRSASTPSKL
Catalytic Activity: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 39272 Sequence Length: 366 Subcellular Location: Glycosome EC: 1.1.1.8
Q6AFK3
MIGAGSWGTTFAKILADGGNDVVVWARRPELAREIDEGKRNSDYLQGINLPRSLRATSHLGEAMRGAEQVFVSLPSQTLRSNLDAMIPYLGPATVVISLMKGVEKGTGLRMSEVIAQGLPIDPEQIAVVSGPNLALEIAREQPTAAVVSSVSPATAVAVATSATNRYFRSFVNTDVIGTEFGGVLKNLIAVAIGIVDGVGYGENTKASIITRGLVEMTDFAVAYGADPQTLSGLAGLGDLIATCESPLSRNNTAGRLLGQGYSFTDVVKQMDQAAEGLASVTPILSLAEARGVEMPIVRQVSQVLAGTLAPKDIAPHLTTDDEPQGERTRGERTTDDGQGQGRTSVWGSLKRAFDQLRDGGGSSRRDRP
Catalytic Activity: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 38846 Sequence Length: 369 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.94
Q4FPT7
MDKQLLIFDFDGTLIDSVPDLADAVNAMLTTLGKAPYPIDTIRNWVGNGSRMLVERALVGKIEVSEGELAKETIDHAEQVFFDAYSKMGGSKTVAYPNVDSGLKKLKAAGFKLALVTNKPIRFVPKILQFFGWHDIFSEVLGGDSLPTKKPDPAPLLHVCEVLNINPAQAVMIGDSINDILAGQNANMDTLGLSYGYNYGQDIRQLNPTEAFDDFSALVDYLLKAYPANN
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 25142 Sequence Length: 230 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q98ML8
MSRPIIVFDLDGTLIDTAPDLLDSLNHSLAASELTAVDEAGFRRFVGHGGRVMIERAHAAQQRSLDVAEHDRLLKLFLDHYTDNIPGKSRPYPGVIEAIARFEKAGYLLAICTNKYEANSLALIEALGLTRHFAAIAGQDTFAFRKPDPRHLTETIRLAGGDAHRALMVGDSQTDIDTAKAAGIPVVAVDFGYTDRHVREFEPSAVISHFDALTVELAERLIRAAGH
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 24821 Sequence Length: 227 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
O33512
MAPALIFDLDGTLIDSAPAIHKVSNDVLRARGYAPLGLDQIRSFVGQGAPHLVRCLLTTAGEDPEGPLFDAIYADLVSRYETDVEGNTLYPGVITALQRLREMGCPMAITTNKPYKPALAAIAHVGLTDYFQLVIGGDSLPTRKPNPEMVNEARRVLRRPHALYIGDSEIDAQTAQNAGLPFVIYTEGYRKTPLDALPHAAKFHDFSALPGIVEGWTWS
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity). Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 23853 Sequence Length: 219 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q2RPW9
MPKAVIFDLDGTLVHSLPGLTDALNKTLAEDDLAPLDEAAVKRMVGEGAGLLVARAFAAYGLGRADDADDTATQARLARFLAHYAPDPLAGASVYPGALALLGALAARGIRLGVCTNKPEGPARALLEGLGLADPIMDVVGGDTLAQRKPDPAPLRALLDSLGVEADQALMVGDSPTDVATAKAAGVPVVVMSYGYSREPVASLGALAVFDDFASLGDWLGFPQPGGDRLGATPALSENPA
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 24507 Sequence Length: 241 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q55039
MQAIIFDFDGTLVDSLPTVVAIANAHAPDFGYDPIDERDYAQLRQWSSRTIVRRAGLSPWQQARLLQRVQRQLGDCLPALQLFPGVADLLAQLRSRSLCLGILSSNSRQNIEAFLQRQGLRSLFSVVQAGTPILSKRRALSQLVAREGWQPAAVMYVGDETRDVEAARQVGLIAVAVTWGFNDRQSLVAACPDWLLETPSDLLQAVTQLMRQ
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 23556 Sequence Length: 212 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q3SGR5
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVKRVLTGEMDAEPDPALFAQAIASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITNKAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLHACEVFGVAPAELLLIGDSLNDTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 24331 Sequence Length: 227 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q9KNV6
MKSIKLIAFDLDGTLLDSVPDLAVAADQAARAVGYPAVSEAQVRDYVGNGADVLIARALSQSLTINPELSPELRAQARHLFDEFYEQTGHKLSHLYPNVKTTLLELHQAGFILALVTNKPSKFVPDVLEQHGIAHFFSDVIGGDTFPNKKPDPMALNWLLEKHQLSAEQMLMVGDSKNDILAAKNAGCYSFGLTYGYNHGEPIANAEPDFVSDDIGTLLEVVLVSA
Function: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 24560 Sequence Length: 226 Pathway: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. EC: 3.1.3.18
Q7NJF7
MALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQDTLRLILEAADQPDVPVIEDQALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPPGGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIRAILMELDHLSPEQVEKVEIEYCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 24664 Sequence Length: 219 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
Q82TU0
MKKLVLLRHGESIWNQENRFTGWTDVDLTPKGLKEAEEAGRLLRENGFSFDIAYTSLLKRAIRTLWIALDEMDQMWTPIELNWRLNERHYGALQGLNKAETAKQYGDEQVLVWRRSYDIRPPSITINDERYPGFDLRYRNMSSGDIPLAESLKDTVARFLPYWNQSIAPQIKAEKKVIIAAHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDDDLKPLNSYYLGDAGQIGEAISAVANQGKSGA
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 28317 Sequence Length: 249 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
Q11SV1
MPILVIVRHGQSEWNLKNLFTGWSDVELTPTGEHEAEYAGIVLRPYHFDIAFTSVLKRAIHTLSIILNQTGATIPIIENEALNERNYGDLQGLNKAEVGEKYGAQQLIAWRRSYTEVPPGGESLENTCQRVIPYYQEKIEPELKDGRNVLIVAHGNSLRALMMHLEKISPEDIAHVDLATGAPRLYEFSSKLDLNSVSYIKLPETPLDVSTLL
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 23920 Sequence Length: 213 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
Q727C0
MARLILLRHGQSAWNLENRFTGWTDVDLSPAGEAEALAAARLIRDEGLDFSVCHTSMLTRAIRTLHLVQQELDRLWTPVRKHWRLNERHYGALQGLDKRETAARHGEDQVFVWRRSYDVPPPVIAPDDPKHPVHDPRYADVPPDVLPCGESLEATVARVLPYWYDAIAPDLMAGRDVLVAAHGNSLRALVMHLDGLDREDVSRLDIPTGLPRLYELDAALRPVSYRYLGDPAEAEERARAVAAQGRLEKN
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 28208 Sequence Length: 250 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
P96121
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHKSWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVARVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAARAQAVADQGKSN
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 28358 Sequence Length: 251 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
Q83HD5
MDNLVLLRHGNSLWNQENLFTGWVDVRLSELGEKEAKTAGQLLREANRYPDVLFTSLLTRSIQTAHIALMEIDRVWLPTFRSWRLNERHYGSLQGKNKAQVLEEFGEEQFNSWRRGYDTPPPPLHSQADDPRYEEPPPLSESLKDVQNRLLPYWQGVILPHLVAGKVVLVVAHGNSLRALVKHLECISDTDVCQLNIPTGIPLVYSIDPSGCATHPGRYLP
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 25123 Sequence Length: 221 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.11
P37689
MLVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQDLTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAESSLKKFEEKFAALGKGRVASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATVIRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAADIKTAVAYPPASLVNTFGEWMAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILINSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYPNGDMVGHTGVMEAAVKAVEALDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKAVEGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA). Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 56194 Sequence Length: 514 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.12
A5FJ26
MNKKVILMILDGWGKSPDPKVSAIDNANVPFINSLYKNYPSAQLRTDGLNVGLPEGQMGNSEVGHMNLGAGRIVYQDLAKINLAVAHKTLAKEQVLIDAFTYAKENNKKVHFLGLVSDGGVHSHTSHLRGLIDASQEYGLDQVYVHAFTDGRDVDPKSGAKYIHDLQDYIKDTPVKIASIVGRYYAMDRDKRWERVKLAYDLVVNGVGTPSTNPVSSVLESYEKDVTDEFIEPVVIVDENAKPLATIVEGDVVIFFNFRTDRGRELTEALSQHDFHEQNMHKLNLYYVTLTNYDETYQNVKVVYNKDNITETLGEVLEKAGKKQIRIAETEKYPHVTFFFSGGREIPFEGESRILRNSPKVATYDLQPEMSAYELADALVPELNKGEVDFVCLNFANGDMVGHTGIMEAAIKACEAVDACAKKVIDAALANDYTTIVIADHGNCETMINPDGSPNTAHTTNPVPIILVDKQLKNIQDGVLGDIAPTILELMGVQQPNAMTCHSLL
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 55874 Sequence Length: 505 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.12
A6H1H2
MNKKVILMILDGWGKSPDPKVSAIDNANIPFINSLYKNYPSAQLRTDGLNVGLPEGQMGNSEVGHMNLGAGRIVYQDLAKINLAVQNKTLSQEKALKEAFQYAKENNKPIHFLGLLSDGGVHSHTSHLRGLLDAAQNFGLKKTFIHAFTDGRDVDPKSAIATIENLNKYIHNTPAKLASVIGRYYAMDRDKRWERIKLAYDLLVNGKGKPSQDAVLSISNSYQNNITDEFIEPIIMTDDNNNPIATIQEDDVVIFFNFRTDRGRELTEALSQQDFHEQNMHKLNLYYVTLTNYDETYKNVKVIYNKDNITQTLGEVLEKAGKKQIRIAETEKYPHVTFFFSGGREQPFLGESRILKNSPKVATYDLQPEMSAYELTEALIPEIEKTEADFICLNFANGDMVGHTGIMSAAIKACQAVNKCVEKVITAALAHNYTTIVIADHGNCETMINPDGTPNTAHTTNPVPIILVDKELKTIHDGVLGDIAPTILDLMGIKKPEVMTRNSLL
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 56282 Sequence Length: 505 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. EC: 5.4.2.12
Q6CZD8
MLSSSSLYAAIDLGSNSFHMLVTRETAGSIQTLAKIKRKVRLAAGLDKQNRLSQEAMQRGWQCLQLFSERLQDIPQDQVRVVATATLRLATNADEFLQRAQEILGLPIQVISGEEEARLIYQGVAHTTGGPDARLVVDIGGGSTELATGIGAKTTQLISLPMGCVTWLDRYFSDRNLEAGNFERAENAAREMLRPVAASLREQGWQICVGASGTVQALQEIMVAQGMDEYITLPKLRQLKEHAIQCDKLEELEIDGLTLERALVFPSGLAILLAIFQELDIKTMTLAGGALREGLVYGMLHLPVDQDIRHRTLATLQRRYLLDTEQAKRVSTLADNFLQQVARDWQLDSRCRELLRSACMVHEIGLSIDFRQSPQHAAYLIRHSDLPGFTPAQKKLLATLLQNQINPIDLMPLSQQNALPVNQAQHLCRLLRLAIIFASRRRDDTLPAVRLRVEGEALRLILPAGWLAQHPLRAEMLEQESRWQSYVHWPLMLEEAPA
Function: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. Catalytic Activity: guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate Sequence Mass (Da): 55719 Sequence Length: 498 Pathway: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2. EC: 3.6.1.40
Q15N19
MITSTRLPQNHPEELYAAVDLGSNSFHLVIVRVVAGSVQIIGKVKQKVRLAAGLDDNMMLDNESLERGWRCLETFAERLQDIPRDNIRVVATATLRLAKNADVFTVKAQQILDHTLSVISGEEEARQIYLGVAYTSANQGNSLVIDIGGASTEIIIGNDMTPIHLVSLNMGCVTFKERHFAGDVLSEENFAAAIDAAKAMVDAVADKFVCFDWQQCLGASGTPQAITEILVAQGISDAIRLDYLYNLRQQCIDCSTLDNLIIDGLDESRRIIFPSGLAILIALFESLSIRDMQISGGALREGLIYGMLENMQQNDRRMQTIHQHMQHFHIDSEQAERVTEVALTLFKQLSEQTDVDGIDGEAMLVAAAMLHETGLHIEYKLHHKHGAYILGHVPMVGYTNLQRDGIKTLVLNHRQQISPEVFDQNHSETRGIMRSLVRVLRLACILSIRRKDNLLPQFCLEVEENDWRLVFPEGWLKAHPLIDAELANEKWQQHKMGWHLTCE
Function: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. Catalytic Activity: guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate Sequence Mass (Da): 56404 Sequence Length: 503 Pathway: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2. EC: 3.6.1.40
Q3IDD5
MGQLKPQKNVYAVIDLGSNSFHMLIAKSIAGGLQTIGRVKRKVRLAAGLDIDNVLSSEAMHRGWECLALFAERLQDIPKQNITIVATATLRLASNADVFKAQAEKILGHKVNVISGELEARTIYKGVAHTSSCTGSQLVIDIGGASTEVIIGKNFDALLYKSLNIGCVTYLERYFKDCKLSNANFNTAIKAARTVIDEIASEYKVKGWQIASGASGTVQAIQEIMIAQNLDELLTLEKLYTIKKQSIAYKTIAALDLPGLSEDRRLVFVSGLAILIALFESLEIEKMGLAGGALREGVLYSMLPELHNSDIRKRTIDGFIDRYHVDQKQASRVASLVLNLASEVNESWPIKALNGLPLLTAVAQLHEIGLLIEYKQYHKHSAYILKNTEMPGFSQSEHKVIVAVAKGHRSDLQKGYFDSLGANSVLAQYLVRLIRIAVILCMRRQDDVLPEFAITVKDDVLNLQFENDWLKNHPLMASELQQESKQQAKLGWKLIVN
Function: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. Catalytic Activity: guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate Sequence Mass (Da): 54968 Sequence Length: 497 Pathway: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2. EC: 3.6.1.40
Q9BZJ8
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES
Function: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway . Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization . May be involved in the regulation of food intake and body weight (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49292 Sequence Length: 451 Subcellular Location: Cell membrane
Q8C010
MESSPIPQSSGNSSTLGRALQTPGPSTASGVPELGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVYWEEGAPSVNPGCSLQWSHSAYCQLFVVVFAVLYFLLPLILIFVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAHQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISAGQVENVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKAAPEEELRLPSREGSIEENFLQFLQGTSENWVSRPLPSPKREPPPVVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAPSPRLES
Function: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49382 Sequence Length: 449 Subcellular Location: Cell membrane
Q9BZJ7
MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS
Function: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways . Has spontaneous activity for beta-arrestin recruitment . Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37614 Sequence Length: 368 Domain: Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity. Subcellular Location: Cell membrane
Q9BZJ6
MVFSAVLTAFHTGTSNTTFVVYENTYMNITLPPPFQHPDLSPLLRYSFETMAPTGLSSLTVNSTAVPTTPAAFKSLNLPLQITLSAIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTTRWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPFLVILYSFMGILNTLRHNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTTILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMMPKSFKFLPQLPGHTKRRIRPSAVYVCGEHRTVV
Function: Orphan receptor. May play a role in brain function. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 47578 Sequence Length: 419 Subcellular Location: Cell membrane
Q6YNI2
MNASAAALNESQVVAVAAEGAAAAATAAGAPDTGEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRTSCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38085 Sequence Length: 363 Subcellular Location: Cell membrane
P51651
MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38115 Sequence Length: 363 Subcellular Location: Cell membrane
Q6X632
MNTSAPLQNVPNATLLNMPPLHGGNSTSLQEGLRDFIHTATLVTCTFLLAIIFCLGSYGNFIVFLSFFDPSFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTNKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQNYNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKDSKAVVTCVVIVLSVLVCCLPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQRKFVDQACGPSHSKESAASPKVSAGHQPCGQSSSTPINTRIEPYYSIYNSSPSQQESGPANLPPVNSFGFASSYIAMHYYTTNDLMQEYDSTSAKQIPIPSV
Function: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 59531 Sequence Length: 540 Subcellular Location: Cell membrane
Q96P69
MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVGFVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTH
Function: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39332 Sequence Length: 363 Subcellular Location: Cell membrane
Q96P67
MNNNTTCIQPSMISSMALPIIYILLCIVGVFGNTLSQWIFLTKIGKKTSTHIYLSHLVTANLLVCSAMPFMSIYFLKGFQWEYQSAQCRVVNFLGTLSMHASMFVSLLILSWIAISRYATLMQKDSSQETTSCYEKIFYGHLLKKFRQPNFARKLCIYIWGVVLGIIIPVTVYYSVIEATEGEESLCYNRQMELGAMISQIAGLIGTTFIGFSFLVVLTSYYSFVSHLRKIRTCTSIMEKDLTYSSVKRHLLVIQILLIVCFLPYSIFKPIFYVLHQRDNCQQLNYLIETKNILTCLASARSSTDPIIFLLLDKTFKKTLYNLFTKSNSAHMQSYG
Function: Orphan receptor. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38409 Sequence Length: 336 Subcellular Location: Cell membrane
Q9NYM4
MVPHLLLLCLLPLVRATEPHEGRADEQSAEAALAVPNASHFFSWNNYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVLFALCWFPLNCYVLLLSSKVIRTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALLSMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIVTMS
Function: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN . Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 48339 Sequence Length: 423 Subcellular Location: Cell membrane
P30731
MKVPPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWVMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCNTIGDVTTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGRRAPLPNHHLPSSQIQSGKTDLSSVEPVVAMS
Function: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN . Plays a role in food intake and body weight regulation . May contribute to the regulation of anxiety-related behaviors . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 48137 Sequence Length: 423 Subcellular Location: Cell membrane
Q8SSH7
MERGMESEAFYGLSARGWDGSEVSLGSFRGCVIMIANVASSCKFAESNYKSFAGLLDKFYRKGLRILLFPCNQYLGQESRPIEEIRGEVSKKYSDRFVVFDKVDVFGKGAHPVFRHLVNTKNGKGRLGNFIKWNFTKFLVDRKGCVVKRFGPSDIVKEDDENLLRSIEDGENGMQNS
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Catalytic Activity: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O Sequence Mass (Da): 20029 Sequence Length: 177 Subcellular Location: Cytoplasm EC: 1.11.1.12
C0HLL8
TELSGAPLDLYQYRGQVLLIPQFTGLLYQKSQQEGDVVDGLPSHQFHQY
Function: Glutathione peroxidase which may protect the cell from oxidative damage. Catalytic Activity: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O Sequence Mass (Da): 5579 Sequence Length: 49 EC: 1.11.1.9
G9JJU2
MSLENGTDVSFEEFRGKVVLVINVATYUGLTVPSYTQMNALAEFYVDQDFVILGFPCNQFEMLEPAANAEIMNGIRYVRPGDGFEPLMTLFEKTEVNGATEDPLFTFLKSACESTYTEFYSSLFYEPIRIGDIQWNFEKFLIGKDGKPYTRYHPDVVDPEALKDDINTLLSA
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (By similarity). May defend against reactive oxygen species that accumulate during the immune response. Catalytic Activity: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O Sequence Mass (Da): 19557 Sequence Length: 172 EC: 1.11.1.9
Q9CX99
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGAEGFVPKNYIRVKPHPWYSGRISRQLAEETLMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKRRQIFLCDEQPLIKPSRACFAQAQFDFSAQDPSQLSLRRGDIVEVVEREDPHWWRGRAGGRLGFFPRSYVQPVHL
Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. Location Topology: Peripheral membrane protein Sequence Mass (Da): 25277 Sequence Length: 217 Subcellular Location: Membrane
Q932F1
MQILLVEDDNTLFQELKKELEQWDFNVAGIEDFGKVMDTFESFNPEIVILDVQLPKYDGFYWCRKMREVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFYTNVLIAKLQAIYRRVYEFTAEEKRTLTWQDAVVDLSKDSIQKGDDTIFLSKTEMIILEILITKKNQIVSRDTIITALWDDEAFVSDNTLTVNVSRLRKKLSEISMDSAIETKVGKGYMAHE
Function: Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. PTM: Phosphorylated by GraS. Phosphorylated by Stk1; phosphorylation increases the DNA-binding activity of GraR. Sequence Mass (Da): 26039 Sequence Length: 224 Subcellular Location: Cytoplasm
P50972
MSLFDGKKVIIIGDRDGIPGPAIAECLKGTAAEVVYSATECFVUTAAGAMDLENQNRVKGFADQFGAENLVVLVGAAEAESAGLAAETVTAGDPTFAGPLAGVQLGLRVFHAVEPEFKDAVDSAVYDEQIGMMEMVLDVDSIIAEMKSIREQFGKFND
Function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. Catalytic Activity: [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate Sequence Mass (Da): 16656 Sequence Length: 158 EC: 1.21.4.2
Q75JT4
MKILLYIAIILSFFSLITISSECKIAVLLSGSPNDLGYNYLMNEARVKAESELKLDFSIYYENLEESMEEAEKAFQDALHKGANLIVVGSFVHVGLGLKYAALTKDQDIYWIIRGNKRPNPDLPHVVILNFNSFELHYLLGYFSGLMTKTGIVGFVAPGPDVNTISTDNSFYLGAKYARPNITFLNVYVQSWYNPNVSYSAAKMLIKNGADLIGMSQDDMSCQKAMMDSGLIGIGATGYPTHLLFGGNVGVSYITNWTNLYVKYAQHVLNDDWPDYSSYFTNLSREDSIFIDDYSYKVPIDIQNLVNDEIQRLKNTSYIPYRSDPYLAQLGIPFDSKGLLVEDQFRANKKLLKGDSISKVIDFGQYSIPIEFIDYPNSLKYGVTIVSGVCIFICLVCMTLVVVFKKARVIKSSSPAFLLLILLGCCIIFAACILFAQSPTNQTCSARIWLLSLGYTLFLGNLLVKNWRIWLLFDNPKLKKRAITNWKLYPWVFAILAIDVMILAIWQGLGNINAESRIGYDSLTQYQYKNVCSSDDQGSIALYLLLVFHGLVLLVACFISFKIKVVDIEEFNESKPITTSVYIITFCLFIVIPLMVSPQSLTSQTTIICVCAIVTTLISMLLLFGSKFYKMATQGLAINETFATSTKSSSKSSKSSYGKDNPNPNAINFGEDDTSDETSEEKHKSPKQKSVNFSNKSNSHLAVFTSDEETSKTSKLSIDFENSSKDISIDQLQQQKQQPINTNGDLENKSNDKIDDDNDNSSVLSKRISNQQNGETEIDSNNV
Function: May act during the development and be a negative regulator. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 87581 Sequence Length: 783 Subcellular Location: Cell membrane
Q09630
MDKKWSLEQRWLHLLNQQFLDCLNHLFNHYRRLSTFQKPPSIIRHMFSVLALAIQILANVNVVAQTTEAVDLAPPPKVRQIRIPGDILIGGVFPVHSKSLNGDEPCGEIAETRGVHRVEAMLYALDQINSQNDFLRGYKLGALILDSCSNPAYALNQSLDFVRDMIGSSEASDYVCLDGSDPNLKKQSQKKNVAAVVGGSYSSVSVQLANLLRLFRIAQVSPASTNADLSDKNRFEYFARTVPSDDYQAMAMVEIAVKFKWSYVSLVYSADEYGELGADAFKKEARKKGICIALEERIQNKKESFTESINNLVQKLQPEKNVGATVVVLFVGTEYIPDILRYTAERMKLTSGAKKRIIWLASESWDRNNDKYTAGDNRLAAQGAIVLMLASQKVPSFEEYFMSLHPGTEAFERNKWLRELWQVKYKCEFDTPPGSTASRCEDIKQSTEGFNADDKVQFVIDAVYAIAHGLQSMKQAICPDDAIENHWISRYSKQPEICHAMQNIDGSDFYQNYLLKVNFTGKTISIFSSFRLSPFSDIVGKRFRFSPQGDGPASYTILTYKPKSMDKKRRMTDDESSPSDYVEIGHWSENNLTIYEKNLWWDPDHTPVSVCSLPCKIGFRKQLIKDEQCCWACSKCEDYEYLINETHCVGCEQGWWPTKDRKGCFDLSLSQLKYMRWRSMYSLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKPSAIVCAIKRTGIGFAFSCLYSAMFVKTNRIFRIFSTRSAQRPRFISPISQVVMTAMLAGVQLIGSLIWLSVVPPGWRHHYPTRDQVVLTCNVPDHHFLYSLAYDGFLIVLCTTYAVKTRKVPENFNETKFIGFSMYTTCVVWLSWIFFFFGTGSDFQIQTSSLCISISMSANVALACIFSPKLWIILFEKHKNVRKQEGESMLNKSSRSLGNCSSRLCANSIDEPNQYTALLTDSTRRRSSRKTSQPTSTSSAHDTFL
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 113276 Sequence Length: 999 Subcellular Location: Cell membrane
Q8IUY3
MTALSRSEATEEGGNQQMHRKTASLNSPVSCKEKPDRVEEPPDYSLHWPEGLKGEEIKKCGREGITLNKYNQQYHKLFKDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQMIKKHKMARLLPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSKKSLSVREFSGEPESLEVLIPEMKWRKVCPSSRSLSLPDNIPCIPPSSVDSTDSFFPSRKPPMSEKSRAQVASENGGRWAWPMPGWGPACPKKMPNCSPTAKNAVYEEDELEEEPRSTGELRLWDYRLLKVFFVLICFLVMSSSYLAFRISRLEQQLCSLSWDDPVPGHR
Function: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). Location Topology: Single-pass membrane protein Sequence Mass (Da): 40249 Sequence Length: 354 Domain: GRAM domain is required for specific location to endoplasmic reticulum-plasma membrane contact sites (EPCS). Mediates interaction to phosphatidylinositol lipids and binding to plasma membrane. Subcellular Location: Endoplasmic reticulum membrane
Q3V3G7
MQMKMMFFCLSDWQSNQQMHGKMAPLKSHVPCTEKPGKVQEPPDDGSLHWSEGSKGEDIKKYSREGTLRSKYNQQYHKLFKDIPLEEVVLKVCSCALQRDLLLHGRLYISPNWLCFHASLFGKDIKVVIPVVSVQLIKKHKMARLLPNGLAITTNTSQKYVFVSLLSRDSVYDMLRRVCTHLQPSSKKSLSIRKFPEEAECESPEVLIPEMKWRKACSAPASLSLPDSISCISQIPTDSTDSCFPSRKPPGSEAVCEKDALEEEPSTDQELRLWDSRLLKVIFVMICFLVLSSSYLAFRISRLEQQLCSLSWGSPLPRDR
Function: Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). PTM: Phosphorylated. Location Topology: Single-pass membrane protein Sequence Mass (Da): 36441 Sequence Length: 320 Domain: GRAM domain is required for specific location to endoplasmic reticulum-plasma membrane contact sites (EPCS). Mediates interaction to phosphatidylinositol lipids and binding to plasma membrane. Subcellular Location: Endoplasmic reticulum membrane
Q14416
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 95568 Sequence Length: 872 Subcellular Location: Cell membrane
P21729
MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
Function: Receptor for gastrin-releasing peptide (GRP) . Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation . Contributes to the regulation of food intake . Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain . Contributes primarily to nonhistaminergic itch sensation . In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear . In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories . Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43215 Sequence Length: 384 Subcellular Location: Cell membrane
A8ETJ2
MFGKSIEAYTKACEVIPGGVDSPVRAFKSVGGTPPFIKKGKGAYLYDVDGNKYVDFVQSWGPLIFGHCDKDIEKVVIKTAKKGLSFGAPTKLETKLASEIVEMYDNIDKVRFVSSGTEATMSAIRLARGVTGKNDIVKFEGCYHGHSDSLLVQAGSGLATFGSPSSPGVPSDLTKHTLLCEYNNIKNLEKCFADSSDIACIIIEPIAGNMGLVPASEEFLKACRELCDKHGALLIFDEVMSGFRASLTGASGIVKTKADIITFGKVIGAGMPVGAFAASKEIMSNLSPEGKIYQAGTLSGNPVAMAAGLKSLRKLKANPDIYDELNKKALRLVNGLKKIANKYEIPFQVDTRGSMFGFFFCEKEPKNFKDVGLCDFKRFATFHHEMLKKGFYFACSQYETGFICTKITNKDIDACLKAANEVMKNL
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 46184 Sequence Length: 426 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
O29027
MKLDKSRKLYAEALNLMPGGVSSPVRAFKPHPFYTARGKGSKIYDVDGNAYIDYCMAYGPLVLGHANEVVKNALAEQLERGWLYGTPIELEIEYAKLIQKYFPSMEMLRFVNTGSEATMAALRVARGFTGRDKIVKVEGSFHGAHDAVLVKAGSGATTHGIPNSAGVPADFVKNTLQVPFNDIEALSEILEKNEVAALILEPVMGNSSLILPEKDYLKEVRKVTAENDVLLIFDEVITGFRVSMGGAQEYYGVKPDLTTLGKIAGGGLPIGIFGGRKEIMERVAPSGDVYQAGTFSGNPLSLTAGYATVKFMEENGVIEKVNSLTEKLVSGIADVLEDKKAECEVGSLASMFCIYFGPTPRNYAEALQLNKERFMEFFWRMLENGVFLPPSQYETCFVSFAHTEEDVEKTVEAVSESL
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 45754 Sequence Length: 418 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
P30949
MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLVIDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPPQEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPVGAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLEEGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGVFLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 46449 Sequence Length: 430 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
P56115
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQSWGPLIFGHADEEIEENIINALKKGTSFGAPTELETTLAKEIISCYEGLDKVRLVSSGTEATMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCATFGSPSSLGVPNDFSKHTLVARYNDLNSTEECFKKGNVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVMSGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGSVYQAGTLSGNPLAVCAGLSALYKIKRDKTLYTRLDALAIRLTQGLQKSAQNYNIALETLNMGSMFGFFFNENAVHDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFETGFICEPMTEEMIDLTIAKADESFDEIIKGV
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 46727 Sequence Length: 430 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
B4U8M6
MTNKEAFELAKKYMPGGVSSPVRAFKSVGAEPIVVNRGFGAFVEDIEGKKYIDYMLSFGPLILGHRSEIVVSKIMEALDKGNSFGITNMYEIELSELIIKASKVIDKVRFVSSGTEAVMSAIRLARGITNKPYIIKFDGCYHGFSDSVLVGAGSGVATLGIPGTPGIPKEFAALTIVLDYNDENALEEAFIKYKNQIAAVLVEPVAGNMGVVLPKESWLKKLRDITKENDALLIFDEVITGFRLALGGAAEYFGIEPDIVCYGKIIGGGMPIGAYGAKNHIMERVAPEGPIYQAGTLSGNPISVASGLAILKTLIKDIAIYDRLSELRAYLTYTLSKMLSEKGIPHRINEIASMFTIFFTDKDVIDFKSAKTSDTALFGKFFRNALKEGVLMPPSQFEAWFLSTAHTKDVVDTTLEKLKKAIDLL
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 46312 Sequence Length: 425 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
A9GDD3
MTNATSAPPARADRAPASKALFDRAAAVLPGGVNSPVRAFRAVGGDPLFIARAQGARLFDADGAEYIDYVGSWGPAILGHAHPAVIEAVREAALGGLSFGAPTELEVRFAEKIRELYPSIDMLRCVSSGTEATMSAIRVARGFTRRDAIIKFEGCYHGHADHLLVKAGSGLATFGAPDSAGVPESIARTTLSLPYNDPAALEAAFAARGGDIAAVILEPVVGNMGCVPPEPGFLALVIDLCRKHGALSIFDEVMTGCRLARGGAQERFGLRPDLTTLGKIVGGGMPLAAYGGRADVMRVVSPLGPVYQAGTLSGNPLAVTAGLATLDRLTPALYERLEELGASLEEGLRAAAEGAGAAACVQRVGSMITLFFTKGPVRSWADAATSDTKRFSAFHAAMLARGIYWPPSQYEAAFLSGAHSEEDIERTIAACREALAA
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 45491 Sequence Length: 437 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Cytoplasm EC: 5.4.3.8
P45621
MAVSAITGARLTLGMSLSSSTRSRTVAMAVSIDPKTDNKLTLTKSEEAFAAAKELMPGGVNSPVRAFKSVGGQPIVIDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALGETMKKGTSFGAPCLLENTLAELVIDAVPSIEMVRFVNSGTEACMGALRLARAYTGREKIIKFEGCYHGHADPFLVKAGSGVATLGLPDSPGVPKAATFETLTAPYNDTEAIEKLFEANKGEIAAVFLEPVVGNAGFIVPKPDFHSFLRKITKENNTLLVFDEVMTGFRLSYGGAQEYFGITPDITTLGKIIGGGLPVGAYGGRRDIMEKVAPAGPMYQAGTLSGNPLAMTAGIETLQRIKEPGTYEYLDKITGELVEGIIEAGKRAGHAICGGHIRGMFGFFFTEGPVYNFADAKKSDTAKFARFFWGMLAEGVYLAPSQFEAGFTSLAHTSDDIKKTIAAAEKVFREI
Catalytic Activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Sequence Mass (Da): 49646 Sequence Length: 466 Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Subcellular Location: Plastid EC: 5.4.3.8
Q8F4D5
MKTKELTQSKIEEVSLEILLRHAVKAKHGLEKESMRVNPDGTLSGTTHPIHLGSSLTNHYIKTDFAEPQLEYATHPRPKVEANIRELQDLHIFTIRKLENELIWPFSMPPVLPEEENEIPLGQYGTSHSGRWKTIYRHGLGLRYGRRMQTISGVHYNFSFSKVFLRQFLGKEISNFTKEEISSLYLHVIRNFLRRVHFLTYLTGSSPVFDFTFLPNPGSLKFEKHKNFTLYSTYATSLRMSEIGYTSKVQDTLGIHYNSLEEYVDRMCYAVHTPYPKYVSFSENKDAQLNPNYLQIENEFYSPIRPKQVPKGDERPLDALLQRGIEYIEIRSLDIDPYSPVGVCRSNLAFTQLILLDSLLKVSPSISEEENFSLKENLNSVIWEGRNPELKINVNGSKRNFQEAGAEYSESLRHYAKILDLHTGRRTYQEAIDFQIKKWKNPDKTPSGKLLSEILKRNIEFREKGIELAQENKRMFSYLEYSPGTLMKMEKETIRSFQEKEELEKQEIQTQYPTVKLCNH
Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 60577 Sequence Length: 520 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2
Q9ZNX6
MTTIFRLASSSSPSLRHDATPHNFHIRKTSISNTFSFSSKNSLSFKRILTSGGSRRFIVAASPPTEDAVVATEPLTKQDLIDYLASGCKTKDKWRIGTEHEKFGFELGSLRPMKYEQISELLNGIAERFDWDKVMEGDNIIGLKQGKQSISLEPGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEEMGIGFLGIGFQPKWERKDIPMMPKGRYEIMKKYMPKVGSLGLDMMFRTCTVQVNLDFSSEADMIRKFRAGLALQPIATALFANSPFTDGKPNGFVSMRSHIWTDTDKDRTGMLPFVFDDSFGFEQYVDFALDVPMYFVYRKKKYIDCTGMTFRDFLAGKLPCIPGELPTLNDWENHLTTIFPEVRLKRYLEMRGADGGPWRRLCALPAFWVGILYDEVSLQRVLDMTADWTLEEREMLRNKVTVTGLKTPFRDGLLKHVAEEVLELAKDGLERRGFKESGFLNAVAEVVRTGVTPAERLLELYHGKWEQSVDHVFDELLY
PTM: The Cys-172-Cys-392 disulfide bridge is known to modulate the enzyme activity according to the redox status. The oxidized form constitutes the active enzyme (By similarity). Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 57677 Sequence Length: 508 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Subcellular Location: Plastid EC: 6.3.2.2
P97494
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAINKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLEEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYSLIWKCNQIADELCECPELLGSGFRKAKYSGGKSDPSA
Function: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 72571 Sequence Length: 637 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2
Q8X0X0
MGLLALGTALDWPDAKQQAHLVRAWGIKQLLEIWNKAKGKERDAMLWGDEIEYLVVNYSKDEPKVLLSLRQADILKALADSKTLKVTGDCAPGTEANADAGNVTLPVFHPEFGRFMLEATPGKPWGIDFKDLLTVEADMKLRRCIAKDHMLSNEHPITLTTFPRIGSPGVFTEPSYPVSGPKLRSQFVPDEIANPHIRFPTLAANIRSRRGRKVQVNVPVFRDENTPWPWKDPTVNYDLHNWPEDDDVRNGAAPDNFIHMDAMAFGMGSCCLQITFQAKNITEGRKMYDQLSPLGPILLALTAATPVYKGFIADTDVRWNQISRAVDDRTPEELGEKPLKNDRWRIPKSRYASNSTYISTDSRLRPEYMDPNLVIDPEIKQQLLDGGMDDRLATHFAHLFIRDPIVIFNEDLQELDLTKTDHFENIQSTNWQHMRFKPPPADNSIGWRVEFRPMEIQITDFENAAFSVFIVLITRAILSFDLNFYIPIVKVDENMETAHARNANLEKKFWFRKNPFPVRTTRRGGSASRSASGTSTPNSGSSRPATPPLGPVEDEYRLMSVNEVINGTAYAKATSKEVTEDAEEGEEFPGLIPLVESYLDSVNMDVATRCGLARYLDLIRKRASGELWTAAKWIREFIAKHPGYKKDSVVSEEITKDLVGAVIEIGEREKRGLGIDDLIGQVPDLEKLFGGFLKGKSPCGGGQAALEQKLKDDDAKVNGVKRKFNEEQ
Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 81879 Sequence Length: 728 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2
Q9NFN6
MGLLTLGTPLPWNETVPYVDYIKEHGIAQFIALYHRLKGREGDQLKWGDEIEYTIVKFDDDAKRVRVSLRAEELLHQLQAGEELNALLGNENCCLWRPEFASYMIEGTPGAPYGGLLACFNVVESNMISRRAEVTRLLENGESIMSISFPALGTPDFTSPPYEPRPDDINSFGCSLFFPDEVIYGGHPRFRNLVRNIRQRRGEKVAINVPIYKDINTPSPYQEDFTKAKDGGQAARAAKSDHIYMDHMGFGMGCCCLQVTFQAVNIDEARWLYDQLTPITPVLLALSAATPVFRSRLADVDSRWDVISASVDDRTAEERGLVPLKNNKFVLEKSRYDTTDCYIYPCSESYNDIPLQYDDKIYKQLIDGGIDDLLAQHIAHMFIRDPLQVFRERIEQDDTKSTEHFETVQSSNWMNMRFKPPPPDSEIGWRVEFRPSEVQLTDFENAAYCCFVVLLTRVMISFRITLILPISALTENMKRAQRRNAVLEQKLLFRKGIATCNSPPCARGAGCTLESDDVVEMTVNEIINGNGNDFPGLIPLMRQYLDSADVDVDSRCTVSQYLSFIQKRASGELQTLAAWMREFISEHPEYKHDSYVGDRIIYDMLKEMDRISKGEISCPKLLGDYCTKTDSRIPMAVRRAEEKLIVSTKKQS
Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 74212 Sequence Length: 652 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2
Q9HTY6
MSDLLSRRLALLGAAANLPLLTECLHGIERECLRVDSDGKLALTPHPRALGSTLTHPQITTDYSEALLEFITPTETDVADTLGDLERIHRFASSKLDGEYLWSPSMPCELPDEESIPIARYGSSMIGRLKYVYRKGLALRYGKTMQCIAGIHYNFSLPERLWPLLRQAEGSELSERDYQSAAYIALIRNFRRYSWLLMYLFGASPALDAGFLRGRPSQLERLDEHTLYLPYATSLRMSDLGYQNNAQAGLTPCYNDLQSYIDSLRQAVSTPYPPYEKVGTKQDGEWVQLNTNILQIENEYYSSIRPKRVTYTGERPVQALAARGVQYVEVRCLDINPFLPLGIDLDEARFLDAFLLFCAFSDSPLLNGECSDATDNFLAVVKEGRRPGLQLQRRGQPVELQVWANELLERIADTAALLDRARGGEAHAAALAAQRAKVADAELTPSAQVLKVMRERGESFEAFSLRQSREHAEYFRQHPLAAEEQARFEKMASDSLAEQTELERDQDGDFDTFVAAYQASILGLISN
Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Mass (Da): 59224 Sequence Length: 527 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2
Q83AL0
MNLKVGVLMDPIANIAIHKDTTFAMLLALQARQHEVYYLEPADIFLRNEKILGSMRRLQVADDPSQWFNLSESEIKPLHALDVLLMRKDPPFNMSYVYLTYLLELAEKQGLFVVNKPASLRDANEKLFTGWFPHCTPKTLVTSRKAILQEFIREQKEVVIKPLGAMAGESIFYLTVNDPNIPVVIETMTANGHQLVMAQRFIPEVKSGDKRIILIDGEPIPYTLARIPPKGDFRGNLARGAKGEGRELTDRDRWICEQVGPTLRKKGLWFVGLDIIGDYLTEINVTSPTGVRELQAQFDVDIAGQFIAFLETKYATTTDIE
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 36319 Sequence Length: 321 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
Q54E83
MEEKLNDLKEQGIDWAFANGLIMIKKPTEEEAKNNVVNVTHVPFSLYPSKMNKKLFNEACKLAEDYNLLVHNISKDYDFLQNTLKDVFDDFTQMLLNIQRKVVKEGIKQKISLGIFRSDYMFHNKIEGEEERIYQVELNTISSSLAVVSNRVFNLHKYLIGRNDLNDNGYDLLNHPTNQSDKEISDSIALAHKLYNKEKSSVVLMIIQEGERNIYDQKGLEFQLWSNHSIKLIRRTMKEINQCAKLDEENGSVLIVDGMEISVAYYRAGYTPNDYTSSGGDEWKARLLIERSLAIKCPTIAHHLVGVKKIQQVLAQPGVLEKFINNDKESLQRVKRSFTGLYSLSKEDIDMSVVKEAIESPQNYVMKPQREGGGNNIYNDQVAIALKSMSSEELSSYILMDKIMSKSFKTHVVRDRQLLEIEGLYELGIYSVFISNGDDDIVLNKQAGILLRTKTANSDEVGVAAGFGLLDSPILE
Cofactor: Binds 1 Mg(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 54140 Sequence Length: 476 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
P04425
MIKLGIVMDPIANINIKKDSSFAMLLEAQRRGYELHYMEMGDLYLINGEARAHTRTLNVKQNYEEWFSFVGEQDLPLADLDVILMRKDPPFDTEFIYATYILERAEEKGTLIVNKPQSLRDCNEKLFTAWFSDLTPETLVTRNKAQLKAFWEKHSDIILKPLDGMGGASIFRVKEGDPNLGVIAETLTEHGTRYCMAQNYLPAIKDGDKRVLVVDGEPVPYCLARIPQGGETRGNLAAGGRGEPRPLTESDWKIARQIGPTLKEKGLIFVGLDIIGDRLTEINVTSPTCIREIEAEFPVSITGMLMDAIEARLQQQ
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 35561 Sequence Length: 316 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
Q7NF44
MKILFIVDPLETLKPGHDTSVALMQAAARRGHSVWAAEVGDLQVHHHRAAAQVRTLTIHPGRTPFYTVEAVGFYPLSEADVIWMRKDPPVTSAYLWATQVLDLVNAGRGDGRTTFVLNRPSGLRNDNEKLYALHFPDLVPETRVCTHRQDILDFVDIHGRAVIKPLDGKGGEGIFLLARADRNLNAIIEASTAYGTRHVMVQRYLEESRQGDKRIVLLAGEPIGALLRVPREDDVRGNMAAGGRVVKTTLTERDREICRVVGPRLVADGHYFVGIDVIGAYLTEINVTSPTGICEIDVLDGVVLEDEIVDWLVEYTRPALARNL
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 35906 Sequence Length: 324 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
P48637
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner . Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes . Participates in ophthalmate biosynthesis in hepatocytes (By similarity). Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 52385 Sequence Length: 474 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
Q9JYJ3
MMKVLFIADPMASFKTYKDTTYAMMREMAKRGWRLFHTLSGELSVNGGLVTAQASAFEFLGAKNDDDHAWFKSADKVQTALEAFDAVIMRTDPPFDMQYLYATQLLTLAEQQGAKVFNSGQAMRDFNEKLAILNFSRFIAPTLVTTRSADVRTFLKEHGDIIIKPLDGMGGMGIFRLTEKDPNIGSILETLMQLDSRTIMAQRYIPEIVHGDKRILIIGGEVVPYALARIPQNGETRGNLAAGGRGVAQELGGRDREIAETLAPELKRRGILLAGLDVIGSNLTEVNVTSPTGFQEIMKQKGFDVAAMFADAVAAWSVR
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 35146 Sequence Length: 319 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
Q7M7H8
MIKLGIVMDPISSINIKKDTSFAMLLEAQRRSWELHYMEMSDLYLHQGEARARTRLLQVENHPQQWYQFDREQDLALETLDVILMRKDPPFDTEYIYATYILERAEEKGTLIVNKPQSLRDCNEKLFTAWFPELTPDTLVTRNAAHLREFHQKHGDVIFKPLDGMGGASIFRLKKDDPNVGVIIETLTEHGNRFCMAQNFLPAIKEGDKRVLIVDGEPVPYCLARIPAQGETRGNLAAGGRGEARPLSESDWAIARAVAPTLQEKGLIFVGLDIIGDKLTEINVTSPTCAREIEAAFPDISITGMLMNAIEERLEK
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 35765 Sequence Length: 316 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
Q7TUK9
MRQLFVLDPLQCIQPAKDSSAALMQAAQRASIEVWACTPADLQARGDQLSAIAVPVVAEPWISTGEPRSLPLTDFACIWMRKDPPVDEGYLYATHLLELAERAGVCVLNRPAALRAWNEKLGALRFNNLMAPTLVASRVSELAAFAREQEEVVLKPLGGRAGQGLVRVAGAAPGLEALLELVTDQEQLPVMVQRFLPAVIEGDKRILLVDGEPLGAVNRRPKAGDFRSNLAMGGRPEPTELDSRELQICAELAPVLREQGLFFVGIDVIDGLLSEINVTSPTGIREVERLKGVPLADQVIARLLVSLG
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate Sequence Mass (Da): 33316 Sequence Length: 308 Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. EC: 6.3.2.3
P41441
MNYRYRAMTQDGQKLQGIIDANDERQARLRLREEGLFLLDIRPQKSSGVKTRRPRISHSELTLFTRQLATLSAAALPLEESLAVIGQQSSNKRLGDVLNQVRSAILEGHPLSDALQHFPTLFDSLYRTLVKAGEKSGLLAPVLEKLADYNENRQKIRSKLIQSLIYPCMLTTVAIGVVIILLTAVVPKITEQFVHMKQQLPLSTRILLGLSDTLQRTGPTLLATVFIVAVGFWLWLKRGNNRHRFHAMLLRVALIGPLICAINSARYLRTLSILQSSGVPLLDGMNLSTESLNNLEIRQRLANAAENVRQGNSIHLSLEQTAIFPPMMLYMVASGEKSGQLGTLMVRAADNQETLQQNRIALTLSIFEPALIITMALIVLFIVVSVLQPLLQLNSMIN
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44339 Sequence Length: 398 Subcellular Location: Cell inner membrane
P15745
MALFRYQALDEQGKPRRGVQQADSARHARQLLREKGWLALDIDPAAGGGRPSRFMRRTSARDLALVTRQLATLVAAAIPLEKALDAVAQQSEKPQLKTLIAGVRGKVLEGHSLAEAMRGHPGCFDALYCAMVAAGEASGHRLLQAMIYPIVLTLVAVSVIVILLSTVVPKVVEQFIHLKQALPFSTRLLMAMSDMLRAAGPWLLLAILLLILLLRYLLRQPAKRLAWHRLLLRLPLIGRVARSVNSARYARTLSILNASAVPLLLAMRISADVLSNAWAKRQLEAASDAVREGVSLHRALEMTQLFPPMMRYMVASGERSGELNSMLERAADNQDRDLSAQIQLALSLFEPLLVVAMAGMVLFIVLAILQPILQLNTLMSM
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 41873 Sequence Length: 381 Subcellular Location: Cell inner membrane
P31705
MAQYHYQALDAQGKKCRGTQEADSARQARQLLRERGLVPLSVDENRGDQQKSGSTGLSLRRKIRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLADAMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTVVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMAFRVMLRQEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDVMSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADNQDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQLNTLMSS
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45162 Sequence Length: 408 Subcellular Location: Cell inner membrane
Q00513
MAAFEYLALDPSGRQQKGVLEADSARQVRQLLRERQLAPLDVKPTRTREQSGQGGRLTFARGLSARDLALVTRQLATLVQAALPIEEALRAAAAQSTSQRIQSMLLAVRAKVLEGHSLAGSLREFPTAFPELYRATVAAGEHAGHLGPVLEQLADYTEQRQQSRQKIQLALLYPVILMVASLAIVGFLLGYVVPDVVRVFIDSGQTLPLLTRVLIGVSDWVKAWGALAFVAAIGGVIGFRYALRKDAFRERWHGFLLRVPLVGRLVRSTDTARFASTLAILTRSGVPLVEALAIAAEVIANRIIRNEVVKAAQKVREGASLTRSLEATGQFPPMMLHMIASGERSGELDQMLARTARNQENDLAAQIGLMVGLFEPFMLIFMGAVVLVIVLAILLPILSLNQLVG
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44062 Sequence Length: 405 Subcellular Location: Cell inner membrane
P45780
MAAFEYKALDAKGRHKKGVIEGDNARQVRQRLKEQSLVPMEVVETQVKAARSRSQGFAFKRGISTPDLALITRQLATLVQSGMPLEECLRAVAEQSEKPRIRTMLVAVRAKVTEGYTLSDSLGDYPHVFDELFRSMVAAGEKSGHLDSVLERLADYAENRQKMRSKLQQAMIYPVVLVVFAVGIVAFLLAAVVPKIVGQFVQMGQALPASTQFLLDASDFLQHWGISLLVGLLMLIYLVRWLLTKPDIRLRWDRRVISLPVIGKIARGLNTARFARTLSICTSSAIPILDGMRVAVDVMTNQFVKQQVLAAAENVREGSSLRKALEQTKLFPPMMLHMIASGEQSGELEGMLTRAADNQDNSFESTVNIALGIFTPALIALMAGMVLFIVMATLMPILEMNNLMSR
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44931 Sequence Length: 406 Subcellular Location: Cell inner membrane
P31744
MPLYRYKALDAHGEMLDGQMEAANDAEVALRLQEQGHLPVETRLATGENGSPSLRMLLRKKPFDNAALVQFTQQLATLIGAGQPLDRALSILMDLPEDDKSRRVIADIRDTVRGGAPLSVALERQHGLFSKLYINMVRAGEAGGSMQDTLQRLADYLERSRALKGKVINALIYPAILLAVVGCALLFLLGYVVPQFAQMYESLDVALPWFTQAVLSVGLLVRDWWLVLVVIPGVLGLWLDRKRRNAAFRAALDAWLLRQKVIGSLIARLETARLTRTLGTLLRNGVPLLAAIGIARNVMSNTALVEDVAAAADDVKNGHGLSMSLARGKRFPRLALQMIQVGEESGALDTMLLKTADTFELETAQAIDRALAALVPLITLVLASVVGLVIISVLVPLYDLTNAIG
Function: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44024 Sequence Length: 405 Subcellular Location: Cell inner membrane
P31733
MQKRRQSGFTLLEVMVVIVILGILASLVVPNLMGNKEKADQQKAVSDIVALENALDMYKLDNNRYPTTEQGLDALVNKPTAAPEPRSYRDGGYIKRLPQDPWGNPYQMLSPGQFGKIDIFSMGLDGEAGTDDDIGNWNLKDFQ
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth. PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15902 Sequence Length: 143 Subcellular Location: Cell inner membrane
P31585
MERRQRGFTLLEIMVVIVILGVLASLVVPNLMGNKEKADKQKAVSDIVALESQLDMYKLDNSRYPTTEQGLGALVKKPTTPPEPRNYPQDGYIRRLPQDPWGAEYQLVSPGRHGKIDVFSYGPDGMPDTDDDIGNWNVGNGAHNNGGNGNGNP
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth. PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 16789 Sequence Length: 153 Subcellular Location: Cell inner membrane
A0A0H3HDD6
MRRQSQRGFTLLEIMVVIVIMGILASLVVPNLMGNKDKADRQKVVSDIVALESALDMYKLDNSRYPTTEQGLQALITKPSVPPEARYYPQDGYIRRLPQDPWGGDYQLVSPGQHGQIDIFSSGQDGVPGTDDDIGNWTLSKK
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm . Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth . PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15792 Sequence Length: 142 Subcellular Location: Cell inner membrane
P31586
MQQSQRGCGQNSYGQSGYRQRGFTLLEIMVVIVILGVLASLVVPNLMGNKEKADRQKAVSDIVSLESALDMYKLDNNRYPSTEQGLKALVTKPTVQPEPRNYPADGYIRRLPQDPWGTDYQLLNPGQHGKLDIFSLGPDGMPGTEDDIGNWNLDKK
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth. PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 17352 Sequence Length: 156 Subcellular Location: Cell inner membrane
Q00514
MQRRQQSGFTLIEIMVVVVILGILAALVVPQVMSRPDQAKVTVAKGDIKAIAAALDMYKLDNFAYPSTQQGLEALVKKPTGNPQPKNWNKDGYLKKLPVDPWGNPYQYLAPGTKGPFDLYSLGADGKEGGSDNDADIGNWDN
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm . Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth . Type II pseudopilus confers increased bacterial adhesive capabilities . PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15449 Sequence Length: 142 Subcellular Location: Cell inner membrane
P45773
MKKMRKQTGFTLLEVMVVVVILGILASFVVPNLLGNKEKADQQKAVTDIVALENALDMYKLDNSVYPTTDQGLEALVTKPTNPEPRNYREGGYIKRLPKDPWGNDYQYLSPGDKGTIDVFTLGADGQEGGEGTGADIGNWNIQDFQ
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm . Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth (By similarity). PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 16080 Sequence Length: 146 Subcellular Location: Cell inner membrane
P31734
MIKRSITRSPSRAGQAGMSLLEIIIVIVLIGAVLTLVGSRVLGGADRGKANLAKSQIQTLAGKIENFQLDTGKLPSKLDDLVTQPGGSSGWLGPYAKPVELNDPWGHTIEYRVPGDGQAFDLISLGKDGRPGGSSYDSDIKYQ
Function: Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm . Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus . Further polymerization triggers pseudopilus growth . PTM: Cleaved by the prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15148 Sequence Length: 143 Subcellular Location: Cell inner membrane
P31735
MRRHRQSGFTLLEVLLVAMLMGLVATAVTLSMGGARGDRELDKQARRFMATLQQAQEYSVMDGRLVGLRIEDHGWQFMQRAAKDRKWQALTGDKILGQVQLPDTMLLAIELEGFSWRTESDEKTERGRDEKERTPQVLIFPGGELSPFVLTLTQQDEDVRYLRTVKADEFGRLRLLQDEEEEE
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. PTM: Cleaved by prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 21070 Sequence Length: 183 Subcellular Location: Cell inner membrane
P24687
MRQRGFTLLEIMLVVLLAGVAATLVMMAIPAPKQQDSGWQIARFKAQLQYAVEDSQMNDHILGIYIQPHRWQYALLQRQVVENSPEEQQRLRYVWIPWQPYRMSVPSELPDSFHIELSTQVGAAGDGTGFSPGNGDPHVLILPGGEVTPFRLTLRNGNDSAWLQVDTNGQVHTSPEAEQKG
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. PTM: Cleaved by prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 20288 Sequence Length: 181 Subcellular Location: Cell inner membrane
P41443
MNQQRGFTLLEMMLVLALVAITASVVLFTYGREDVASTRARETAARFTAALELAIDRATLSGQPVGIHFSDSAWRIMVPGKTPSAWRWVPLQEDAADESQNDWDEELSIHLQPFKPDDSNQPQVVILADGQITPFSLLMANAGTGEPLLTLVCSGSWPLDQTLARDTRP
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. PTM: Cleaved by prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 18565 Sequence Length: 169 Subcellular Location: Cell inner membrane
A0A0H3H546
MRQRGFTVLEMMLVVLLMGSAASLVIMSFPAMQQDTAERQLQRFQAQLEFAMDSGMQNDRLLGIQIRPNGWQFQVLQSQAAETRSSVAHSDRWQGYVWQIWQPRQAALGGQVPDNQPLTLRLPPPQEWPPTAEPAADPDILLLPGGEITPFTLIFGEKDDRSEVWLRVDESGAIATSAKGGAP
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm . Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates (By similarity). PTM: Cleaved by prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 20341 Sequence Length: 183 Subcellular Location: Cell inner membrane
P15747
MRQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDSAAQTLARFEAQLRFVQQRGLQTGQFFGVSVHPDRWQFLVLEARDGADPAPADDGWSGYRWLPLRAGRVATSGSIAGGKLNLAFAQGEAWTPGDNPDVLIFPGGEMTPFRLTLGEAPGIAFNARGESLPEPQEAQ
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. PTM: Cleaved by prepilin peptidase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 18403 Sequence Length: 170 Subcellular Location: Cell inner membrane
Q96324
MVVKVYGQIKAANPQRVLLCFLEKDIEFEVIHVDLDKLEQKKPQHLLRQPFGQVPAIEDGYLKLFESRAIARYYATKYADQGTDLLGKTLEGRAIVDQWVEVENNYFYAVALPLVMNVVFKPKSGKPCDVALVEELKVKFDKVLDVYENRLATNRYLGGDEFTLADLSHMPGMRYIMNETSLSGLVTSRENLNRWWNEISARPAWKKLMELAAY
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 24637 Sequence Length: 214 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q9FE46
MVVKLYGQVTAACPQRVLLCFLEKGIEFEIIHIDLDTFEQKKPEHLLRQPFGQVPAIEDGDFKLFESRAIARYYATKFADQGTNLLGKSLEHRAIVDQWADVETYYFNVLAQPLVINLIIKPRLGEKCDVVLVEDLKVKLGVVLDIYNNRLSSNRFLAGEEFTMADLTHMPAMGYLMSITDINQMVKARGSFNRWWEEISDRPSWKKLMVLAGH
Function: Involved in the transport and/or accumulation of both anthocyanins and proanthocyanidins (PA)s in the vacuole. Functions in the cytosol to maintain the regular accumulation in the vacuole of PA precursors, such as epicatechin and glycosylated epicatechin. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 24581 Sequence Length: 214 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q9LZI9
MAMKLYGDEMSACVARVLLCLHEKNTEFELVPVNLFACHHKLPSFLSMNPFGKVPALQDDDLTLFESRAITAYIAEKHRDKGTDLTRHEDPKEAAIVKLWSEVEAHHFNPAISAVIHQLIVVPLQGESPNAAIVEENLENLGKILDVYEERLGKTKYLAGDTYTLADLHHVPYTYYFMKTIHAGLINDRPNVKAWWEDLCSRPAFLKVSPGLTVAPTTN
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 24652 Sequence Length: 219 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q9C6C8
MADSKMKLHCGFIWGNSAALFCINEKGLDFELVFVDWLAGEAKTKTFLSTLNPFGEVPVLEDGDLKLFEPKAITRYLAEQYKDVGTNLLPDDPKKRAIMSMWMEVDSNQFLPIASTLIKELIINPYQGLATDDTAVQENKEKLSEVLNIYETRLGESPYLAGESFSLADLHHLAPIDYLLNTDEEELKNLIYSRPNVAAWVEKMKMRPAWLKTVVMKNHIVDLMKQRRLPIKLDSSCHESTVVAQKNAIAIENK
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 28819 Sequence Length: 254 Subcellular Location: Cytoplasm EC: 2.5.1.18
P48438
XVAFETVPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYXLLSAVLDVYEAHLHGYLAGDFVSLADLAHLPFTDYLV
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 8268 Sequence Length: 76 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q04522
MTIKVHGNPRSTATQRVLVALYEKHLEFEFVPIDMGAGGHKQPSYLALNPFGQVPALEDGEIKLFESRAITKYLAYTHDHQNEGTSLIHKEKHEMAAQLVWEEVEAHQFDPVASKLAWELVFKGIFGMQTDTTVVEENEAKLAKVLDVYEARLTESEYLGANDSFTLVDLHHLPLLGYLMGTQVKKLFEERAHVSAWCKKILARPSWEKTLALQKQA
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 24599 Sequence Length: 217 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q06718
MIQFVIPSYQRVGAVSALDMFPTDYEPHIVVREHEEKAYNDAYGSRAKIITIPDGVNGIAGTRKAITDMYAGQRIWMIDDDTTIRMSSMRKRDDRRCVDKVNQLTHEQFYELIQYVEDAMDCGYYHGHARLPIFKITSSWGNYRENSYGFTNTWYDLGKLTTEQIGYGKIDLCEDMYAFLNLINQGYPHLALFKYLVVSGKAQAPGGCSSIRSNSKHNRALEQINREFPEQARWKTSNIEKRKSLGEEDEPLKVLRMCVSRKEKSEAFHKFNAIHPIAVD
Function: Transfers a gentiobiosyl-group on a hydroxymethylcytosine residue in DNA. Is involved in a DNA modification process to protects the phage genome against its own nucleases and the host restriction endonuclease system. Sequence Mass (Da): 32300 Sequence Length: 280 Pathway: Genetic information processing; DNA modification. EC: 2.4.1.-
Q9Y2Q3
MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL
Function: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds . Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) . Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 25497 Sequence Length: 226 Subcellular Location: Peroxisome EC: 2.5.1.18
P24473
MGPAPRVLELFYDVLSPYSWLGFEVLCRYQHLWNIKLKLRPALLAGIMKDSGNQPPAMVPHKGQYILKEIPLLKQLFQVPMSVPKDFFGEHVKKGTVNAMRFLTAVSMEQPEMLEKVSRELWMRIWSRDEDITESQNILSAAEKAGMATAQAQHLLNKISTELVKSKLRETTGAACKYGAFGLPTTVAHVDGKTYMLFGSDRMELLAYLLGEKWMGPVPPTLNARL
Function: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 25493 Sequence Length: 226 Subcellular Location: Mitochondrion matrix EC: 2.5.1.18
Q18973
MPNRKVVKFFFDVISPYSYFGFEGITRHRSVWKTPIQMKPFFFAGVVRHTENPGLPLRIPIKEKYMHKDLLFSAQYWGIPFRLPKDYTNMMLNTSSIVPQRILVASQLRDNVLMEDVARGLWHRFYAYGKPIFTKSQVAEVLRDLHVKDVDELVMMSDSAEVKNILRENTDEAIGNGCFGAPWMHITDGHGKVLQTVFGSDRLPQVADFLAEPFKGPMREKKPNA
Function: Has roles in respiratory and lipid metabolism. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 25951 Sequence Length: 225 Subcellular Location: Mitochondrion EC: 2.5.1.18
Q6NLB0
MALSPPKIFVEDRQVPLDATSDPPALFDGTTRLYISYTCPFAQRVWITRNLKGLQDEIKLVPIDLPNRPAWLKEKVNPANKVPALEHNGKITGESLDLIKYVDSNFDGPSLYPEDSAKREFGEELLKYVDETFVKTVFGSFKGDPVKETASAFDHVENALKKFDDGPFFLGELSLVDIAYIPFIERFQVFLDEVFKYEIIIGRPNLAAWIEQMNKMVAYTQTKTDSEYVVNYFKRFM
Function: Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. In vitro, possesses glutathione-dependent thiol transferase activity toward 2-hydroxyethyl disulfide (HED). Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 27167 Sequence Length: 237 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q9M2W2
MSVGLKVSAFLHPTLALSSRDVSLSSSSSSLYLDRKILRPGSGRRWCKSRRTEPILAVVESSRVPELDSSSEPVQVFDGSTRLYISYTCPFAQRAWIARNYKGLQNKIELVPIDLKNRPAWYKEKVYSANKVPALEHNNRVLGESLDLIKYIDTNFEGPSLTPDGLEKQVVADELLSYTDSFSKAVRSTLNGTDTNAADVAFDYIEQALSKFNEGPFFLGQFSLVDVAYAPFIERFRLILSDVMNVDITSGRPNLALWIQEMNKIEAYTETRQDPQELVERYKRRVQAEARL
Function: Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. In vitro, possesses glutathione-dependent thiol transferase activity toward 2-hydroxyethyl disulfide (HED). Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 33058 Sequence Length: 292 Subcellular Location: Plastid EC: 2.5.1.18
Q9LZ06
MAPSFIFVEDRPAPLDATSDPPSLFDGTTRLYTSYVCPFAQRVWITRNFKGLQEKIKLVPLDLGNRPAWYKEKVYPENKVPALEHNGKIIGESLDLIKYLDNTFEGPSLYPEDHAKREFGDELLKYTDTFVKTMYVSLKGDPSKETAPVLDYLENALYKFDDGPFFLGQLSLVDIAYIPFIERFQTVLNELFKCDITAERPKLSAWIEEINKSDGYAQTKMDPKEIVEVFKKKFM
Function: Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. Catalytic Activity: glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Sequence Mass (Da): 27090 Sequence Length: 235 Subcellular Location: Cytoplasm EC: 2.5.1.18
Q8IYK4
MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRPMDEPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDYVQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTFYPPHQDYTWTFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQYVSVVPKYPDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLMKLMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPFGKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHAWKSRKQSRIYSNAKNTEALPPPTSLDTVPSRDEL
Function: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen. Catalytic Activity: (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP Sequence Mass (Da): 72924 Sequence Length: 626 Subcellular Location: Endoplasmic reticulum lumen EC: 2.4.1.50