ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
O14793
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Function: Acts specifically as a negative regulator of skeletal muscle growth. PTM: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. Sequence Mass (Da): 42750 Sequence Length: 375 Subcellular Location: Secreted
P37020
MPTTYVPINQPIGDGEDVIDTNRFTNIPETQNFDQFVTIDKIAEENRPLSVDSDREFLNSKYRHYREVIWDRAKTFITLSSTAIVIGCIAGFLQVFTETLVNWKTGHCQRNWLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWKGHVSPFIIFMLLSVLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKEGPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKWNINFIHFRKMYLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHRLCQLDENTHAFEFLKIFTSLCFATVIRALLVVVSYGARVPAGIFVPSMAVGATFGRAVSLLVERFISGPSVITPGAYAFLGAAATLSGITNLTLTVVVIMFELTGAFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSKLITINETIYLSELESLLYDSASEYSVHGFPITKDEDKFEKEKRCIGYVLKRHLASKIMMQSVNSTKAQTTLVYFNKSNEELGHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGCKTIIVEESGILKGLVTAKDILRFKRIKYREVHGAKFTYNEALDRRCWSVIHFIIKRFTTNRNGNVI
Function: Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane. PTM: Proteolytically processed in the secretory pathway by protease KEX2 within the first extracellular loop. However, both the N- and C-terminal products of the cleavage reaction are required for assembly of a functional channel. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 87592 Sequence Length: 779 Subcellular Location: Golgi apparatus membrane
Q93LK9
MKPYGKIPDNSIKSLQDLMQLLKKSKDFITLEIASNNSSIVISYFRTLIDVNIFHEEVLTYIKEKSFNSLQDIHSVLPFENSKITNQIEDIQDSILNGYILIQYDTDKLNCLLVNVSKKEKRDITKAEIEYNIVGPQIAFVEDLDVNLNLVRRKLPTPYLQMKELKVGSLSNTTVAIVFIEGIVNDQNLQEIIKRVSQIKTDHVLDSTYLMQLIADNPNSIFPQFLNTERPDRVAAVLAEGKIALFVDGSPYAITLPTTLIDFFSTTEDYTMPWIIASFFRLLRLFAFIFSVLTTPLYVSILTYHYELIPKELLETLIISRSKVPFPPLIEALFLEITIELLREAGARLPTKVGLTVGIVGGIVIGQASVEASLTSNVLIIIVALSALSSFTAPIYRIGNTIRVIRFPFIISAHLLGLLGIVLTSSLLLARLLRTESLRRPYLFPFYPTRPTDWKDSIIRMPISAMFRRPIFSRSKQRFRFNPEEVEKNKILSRNDFDD
Function: Required for the germination response to inosine. Has no role in L-alanine germination. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56786 Sequence Length: 499 Subcellular Location: Membrane
Q93LK8
MKQIPIEYQVSPYMVFFLIITIQMGVGMLGFERISAKLVGNDAWISTLLFGISVNVMIWIIYQILNQGNGDIIAINQNVLGKWIGGLLNFIFLSYIVLLGATTLHTYIEVVHVWMFPSISSWVIAGAFLGLCYYIVTGGFRVVAGIGFFGIVIPSILIFTFFYPLQYADFRNLFPIAQHSFLEIMKGMKGNMFSFFGFEMLLLYYPFIKKARTSQKYAHYANLVTTIVYTYLMILTLAFFSEKQLANAIWAYLSMIKIIQFPFIERFEYIIVSVWAFFILPNVSFTLWGVSRGIKEALGIKQKYVLPVIILFIFILSFFLNNRNKINLLNTWTGQIGFVYIYVYLPVLWLIQTAKIKLRR
Function: Required for the germination response to inosine. Has no role in L-alanine germination. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 41556 Sequence Length: 360 Subcellular Location: Membrane
Q93LK7
MKRWILFLILSVFLIGCAKTKIVDDIDLVQVAAYDTEAEGKLKGTFAISAYKGGGEGETKIYSASGQTGREVLARASEKSSGPLELGQLRVIIFNEKIIEKGMQEILETLNRNPSVGNAIYLAITNVKGESLLKGNYSKEKEIASYLSSLLEQNMNNGTQPKTNFFMFLNQLDDDARDSYLPMISKKGNVLELNGIALFKRCKMVDKVNPKDLFVFKLLTDNFKQGTYQFKLPGSSNTYATIENIKARTKYKMEGNSKHPFVNAHIQVKAEIQEFTKTKNLDNPKEIKKLEKIMGKEIEKKATTLIKRFIKKDTDPIGLRKLGRTHVRKWNSQEWEESYKHLRFRVTADVKVTQSGVTE
Function: Required for the germination response to inosine. Has no role in L-alanine germination. Location Topology: Lipid-anchor Sequence Mass (Da): 40665 Sequence Length: 359 Subcellular Location: Membrane
P39620
MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQPMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDYITFDEEIAYTYPYSMASYSPR
Function: Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA. PTM: Three N-terminal lysines form epsilon-(gamma-glutamyl)lysine isopeptide bonds with glutamines of other spore coat proteins. Sequence Mass (Da): 20276 Sequence Length: 181 Subcellular Location: Spore coat
Q8GUE4
MALQMIAPFLSSFLPNPRHSLAAHGLTHQKCVSKHISCSTTTPTYSTTVPRRSGNYKPSIWDYDFVQSLGSGYKVEAHGTRVKKLKEVVKHLLKETDSSLAQIELIDKLRRLGLRWLFKNEIKQVLYTISSDNTSIEMRKDLHAVSTRFRLLRQHGYKVSTDVFNDFKDEKGCFKPSLSMDIKGMLSLYEASHLAFQGETVLDEARAFVSTHLMDIKENIDPILHKKVEHALDMPLHWRLEKLEARWYMDIYMREEGMNSSLLELAMLHFNIVQTTFQTNLKSLSRWWKDLGLGEQLSFTRDRLVECFFWAAAMTPEPQFGRCQEVVAKVAQLIIIIDDIYDVYGTVDELELFTNAIDRWDLEAMEQLPEYMKTCFLALYNSINEIGYDILKEEGRNVIPYLRNTWTELCKAFLVEAKWYSSGYTPTLEEYLQTSWISIGSLPMQTYVFALLGKNLAPESSDFAEKISDILRLGGMMIRLPDDLGTSTDELKRGDVPKSIQCYMHEAGVTEDVARDHIMGLFQETWKKLNEYLVESSLPHAFIDHAMNLGRVSYCTYKHGDGFSDGFGDPGSQEKKMFMSLFAEPLQVDEAKGISFYVDGGSA
Cofactor: Binds 3 Mg(2+) or Mn(2+) ions per subunit. Function: Monoterpene synthase that catalyzes the formation of geraniol from geranyl diphosphate. Catalytic Activity: (2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate Sequence Mass (Da): 69081 Sequence Length: 603 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. Subcellular Location: Plastid EC: 3.1.7.11
Q6USK1
MSCARITVTLPYRSAKTSIQRGITHYPALIRPRFSACTPLASAMPLSSTPLINGDNSQRKNTRQHMEESSSKRREYLLEETTRKLQRNDTESVEKLKLIDNIQQLGIGYYFEDAINAVLRSPFSTGEEDLFTAALRFRLLRHNGIEISPEIFLKFKDERGKFDESDTLGLLSLYEASNLGVAGEEILEEAMEFAEARLRRSLSEPAAPLHGEVAQALDVPRHLRMARLEARRFIEQYGKQSDHDGDLLELAILDYNQVQAQHQSELTEIIRWWKELGLVDKLSFGRDRPLECFLWTVGLLPEPKYSSVRIELAKAISILLVIDDIFDTYGEMDDLILFTDAIRRWDLEAMEGLPEYMKICYMALYNTTNEVCYKVLRDTGRIVLLNLKSTWIDMIEGFMEEAKWFNGGSAPKLEEYIENGVSTAGAYMAFAHIFFLIGEGVTHQNSQLFTQKPYPKVFSAAGRILRLWDDLGTAKEEQERGDLASCVQLFMKEKSLTEEEARSRILEEIKGLWRDLNGELVYNKNLPLSIIKVALNMARASQVVYKHDQDTYFSSVDNYVDALFFTQ
Cofactor: Binds 3 Mn(2+) ions per subunit. Function: Monoterpene synthase that catalyzes the formation of geraniol from geranyl diphosphate. Catalytic Activity: (2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate Sequence Mass (Da): 64933 Sequence Length: 567 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. Subcellular Location: Plastid EC: 3.1.7.11
E8W6C7
MTSQASAPKIPQLWVPLPSGIHPSWREIDQGSAAWLDRFGLYSDHAQRERLTRISVGEITGRGGPDGRLAALQWTADFLMWLFAFDDEYCDEGPAAASPDATLLIITKLQRIVEVPWAAPADDNYSAALLELRLRLDDLTTPVQTARWAASFRAYLQGQIWMAANSTYGRIPTLSDHLAVRLDSSGVKIFSTLSEIIHGYDLPAADYDRHDVRGFVEVFAAIIGWSNDLVSYHKERRRSQDSYGNVVDLIAHERQCSVEEAVSETATMHTRAMALYLRLRDQILRDAEPELRKWITDCDSWIRADYDWSLTTHRYVNPDDPADLPVGSAEAPFRAREADQPLPIASVSWWWTLLKD
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the sesquiterpene (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol via a putative 1,10-cyclization, which could require the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP). Catalytic Activity: (2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate Sequence Mass (Da): 40241 Sequence Length: 356 Domain: The Asp-Asp-Xaa-Xaa-Xaa-Asp (DDXXXD) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 4.2.3.166
Q0UP11
MASAALIDSDMEPTLQPILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKHRKSVLLISTDPAHNLSDAFNQKFGKDARLINGFDNLSAMEIDPNGSIQDLLAGGGESGEDAMAGLGGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSMSYEVIIFDTAPTGHTLRFLQFPTVMEKALSKVSQLSRQFGPMLNSFLGGGGRLPNGQNIDELVEKMEALRGTISEVNGQFKDADLTTFVCVCIPEFLSLYETERMIQELNSYEIDTHSIVVNQLLFPKQDNPCEQCNARRKMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKEKLEK
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 36029 Sequence Length: 326 Subcellular Location: Cytoplasm EC: 3.6.-.-
B2VVF0
MASAALIDADMAPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKHRKSVLLISTDPAHNLSDAFNQKFGKDARLVNGFDNLSAMEIDPNGSIQDLLASGAEEGQDPMAGLGGMGSMMQDLAFSIPGVDEAMSFAEVLKQVKSMSYEVIIFDTAPTGHTLRFLQFPTVMEKALSKVSQLSRQFGPMLNSFLGASGRLPNGQNMDELIEKMENLRETIGEVNGQFKDADLTTFVCVCIPEFLSLYETERMIQELNSYEIDTHSIVVNQLLFPKQDNPCEQCNARRKMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLVKPFVPPQ
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 37663 Sequence Length: 339 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q9P7F8
MSFDPLPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKVRSSVLLISTDPAHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQADQQNPNNPLSGMMQDLAFTIPGIDEALAFAEILKQIKSMEFDCVIFDTAPTGHTLRFLNFPTVLEKALGKLGGLSSRFGPMINQMGSIMGVNANEQDLFGKMESMRANISEVNKQFKNPDLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPNTTCPQCMARRKMQQKYLAQIEELYEDFHVVKVPQVPAEVRGTEALKSFSEMLVKPYVYPTSGKE
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 36548 Sequence Length: 329 Subcellular Location: Cytoplasm EC: 3.6.-.-
A7EHP6
MSTAVINTDDDQLEPTLQSILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLINGFENLSAMEIDPNGSIQELMGQAEEGEGPAAGMGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPTVLEKALAKVSQLSTQFGPMLNGLLGANGSLPNGQNLGEMMEKLEGLRETISEVNGQFKDENLTTFVCVCIPEFLSLYETERMIQELSSYHIDTHCIVVNQLLFPKKGSDCDQCNARRKMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKERLEKFSEMLITPYVPPAGGL
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 37544 Sequence Length: 340 Subcellular Location: Cytoplasm EC: 3.6.-.-
C4JZ54
MSSAVVPADDILEPTLQNILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFDNLSAMEIDPSASMQDLMAAGGDQAEDMGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKGLAKLSQLSSQFGPMLNSVLGARGGLPGGQNLDDVLSKMESLRETISEVNTQFKNADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHAIVVNQLLFPGKDSTCDQCKARRKMQKKYLNEIEELYEDFNVVRMPLLVEEVRGKEKLERFSDMLVHPYQPPQE
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 37303 Sequence Length: 338 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q0IIZ2
MAAPADDEFEDAPDVEPLEPTLSNVIDQRSLRWIFVGGKGGVGKTTCSCSLAVQLSRVRESVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPDEIFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQLVFPEPEKPCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGAENVNTFSKLLLEPYKPPSGK
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. Sequence Mass (Da): 38331 Sequence Length: 342 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q84L08
MSSSRFDSNKQLTTSSLVIGYALCSSLLAVINKLAITYFNYPGLLTALQYLTCTVAVYLLGKSGLINHDPFTWDTAKKFLPAAIVFYLAIFTNTNLLRHANVDTFIVFRSLTPLLVAIADTVFRSQPLPSRLTFLSLVVILAGAVGYVATDSSFTLTAYSWALAYLVTITTEMVYIKHMVSNIKLNIWGLVLYNNLLSLMIAPVFWFLTGEFTEVFAALSENRGNLFEPYAFSSVAASCVFGFLISYFGFAARNAISATAFTVTGVVNKFLTVVINVLIWDKHATPVGLVCLLFTICGGVGYQQSVKLDKPIEKVSEKDSEKGEEDEELTQLVPGKLASVV
Function: Acts as the major nucleotide-sugar transporter for the import of GDP-Fucose into the Golgi lumen. Transports GDP-Fucose in a strict counter-exchange mode. Is required for proper plant growth and development . Acts also as a GDP-mannose transporter that may be involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37386 Sequence Length: 341 Subcellular Location: Golgi apparatus membrane
P92916
MDAQDIESRHPLIGARPRRRALRSLSILLAAALLLGLVLFYANGTGSGTAVDPVRVDNEFPWTNDMLAWQRCGFHFRTVRNYMNDPSGPMYYKGWYHLFYQHNKDFAYWGNITWGHAVSRDLINWQHLPVAVGPDHWYDISGVWTGSIIVVSEDRVVMLFTGGTKSFDQSINLAEAADPSDPLLLKWIKYDNNPILWPPPGIVRDDFRDPNPIWYNASESTYHIVVGSKNDSLQHTGIALVYLTKDFKKFDLLPTVLHSVDKVGMWECVEVYPVATTGPLLHKAIDNFDVDRVLDRSTVKHVLKASMNDEWHDYYAIGTFDPIGNKWTPDDETVDVGIGLRYDWGKFYASRTFFDPLKQRRIIWGYIGEVDSQKADIAKGWASLQGIPRSVLYDVKTGTNVLTWPIEEMEGLRMARKDFSGIKIKKGSTVELSDFGDAFQIDIEAEFTISKEALEATIEADVGYNCSSSGGAAIRGTLGPFGLLVLANQDLTENTATYFYVSKGIDGSLITHFCQDETRSSKANDIVKRVVGGTVPVLDGETFAVRILVDHSVIESFAMGGRTSATSRAYPTEAINSAARVFLFNNATGVDVIAESVKIWQMNSTYNDFYHF
Function: Involved in the synthesis of fructan of the inulin neoseries. Catalyzes a self-transfer between identical oligosaccharides of the 1-kestose series. PTM: Might be processed in two N-terminal and C-terminal proteolytic fragments. Location Topology: Single-pass type II membrane protein Catalytic Activity: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0, n >= 0). Sequence Mass (Da): 68631 Sequence Length: 612 Subcellular Location: Vacuole membrane EC: 2.4.1.100
I3L273
MKSFSRILFLVFLLAGLRSKAAPSAPLPLGCGFPDMAHPSETSPLKGASENSKRDRLNPEFPGTPYPEPSKLPHTVSLETFPLDFTEPLNPDLRETPHPESPETPKADSLTTSISESLDMPKTNLSKMAHPESSETPTPGPTEMPHPGSPETPKPNFSKTSRPEFPETPNTDLMQTTPQESPEILQLNATEVSQAELPETSNTNPTKTPDPKSPEKHDLNSTETPNSEFLQALHPDPSKTPHPESHVTHNPSPTEISQTEFPTTYYQNATDVPRTSDPQISTSLYPETPVPFKDDATALNELSLNPKPGTPAAIQPDSPKLPTSDSPGMVELKAPQNSGPKESNVPPPSARIAGPPALPGRPSQLAPATLRAPQRHSRGEGVNTIIVVERVKETGVTLVGRPRGAAGGALCLFFAGTALLIGIFVLLWCLYRRAARQRPFAHHRLPDDGDEPVLHLDAPKDPYDLYFYAPDTWVPSHIATKQPPPTPPLPPKLPPPPRGGRPQRLEALSPATLPNNFV
Function: Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 56104 Sequence Length: 518 Subcellular Location: Golgi apparatus membrane
J3KML8
MQPFSPIFFHLLFLLNGLSSRAAPSPGQPVVADLQGMLQPSGMPTGTLENLTRDQPTPGSSASHPPEHSETPPSASPHISTKILRETPSPSPFLSLETPIPDQLTSVAESQGTSQMSPSRATLGKPSETPKPDPTGISPSDSPETPKPNPSNTSPPESPESVYTDPTPTLHHESPEISKRDTPKLSPGEESKIPSPRPTQFLSSKSLETYDPSATRHLNSALEPTTHPDPTESPQSVFLTTHNSNPTVVPQTQFPTSPSQNVTETARTSDLEPSSSLPTQPTTFREEATTPSEPGLSPSPEAPAVTRVATPGLSTSDSPGTKELHVPQNSDPKGPDIPLPSARIAGPPAPLEHPNQVAPAPQRHSRGDTVNTIIVVERVKETGVTLVSRPRGSVGGALCLFFAGTGLLIGIFLLLWCLYRRASRHRSFAHHRLRDSGDEPVLHLDAPKDPLDLYFYAPDAWVPSHIATQPPPSTPPLPPKLPPPPRGPQRLEALSPAALSPNFF
Function: Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 53786 Sequence Length: 504 Subcellular Location: Golgi apparatus membrane
Q5YKI7
MKEEDSSFKLCVPGIVALQSPPNKAFRSTDTVGFLESELKKLLGMQQESRLWKLGSQEGRELLTRPEITVVEGEGYEVQRRLRHLPSPISVAQCLLLEEKGEMGNWPPE
Function: May be involved in spermatogenesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 12309 Sequence Length: 109 Subcellular Location: Cytoplasm
Q6K1E7
MAAPARTPRSRILGCSSMLRFLRNLVGSKGGSKSTNKPLTRSQPSSSWEQDVVSPMMGHQGGRGRKEPRAKVHSAASSNGKREPPPRVLSAAPSNPRHDAFELGTGDSGSQTLTSKDVPKLRAQGVEVTSVPLRGTWEVLEQLPEKKGEEEEPVGEVSGASDREHFGQALETEQGCLQWVPGPLALTPGAFIKEEEDEHCPIEFGDLKPSSCKVGSTPWNYLLGLYKQLQKSAMAKAQRPAAPQLALKDGLPHEEKGEREEAVDESCPKWCAPRASSDESCPKWCAPRASTYQSPLQKKFRSTDTVGFVESELKKILSVQREARLWKVGNPEGRELLTQPDITLEEAGMVDGQHLLLEEMDEMGNWPPPD
Function: Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 40505 Sequence Length: 370 Domain: The N-terminal domain is required for targeting to the mitochondrion. Subcellular Location: Cytoplasm
Q5J2D6
MAAQARTPRSRILGCSSMLRFLRSLVGSKGSSKSSNRPLNRSQPSSSPEQDVVSPTMGHQGGCGRKETRPRVLSATSSNGKREPRPRVLSAAPSNQRLRDASGLGTGDTGSQTLTSKDVLKLRAQGVEVTSVPTRGTWEVLEHLPEKKGEEGEPAGEVSGASDRAHFGQALEAEQGCLQWVSGPMVLPPEAFIKEEEDEHCLIDFGDLRLSSCKVGSTPWNYLLGLYKQLQKSAMTKAQRPDADAPQFALKDSSPTEERGEREEAVDESSLKWCAPRASSDDSNLKWCAPRNSTYQSPLQKTFRSTDTVGFVESELKKILAVQREARLWKVGNPEGRELLTQPDITLEEAGMVDGQHLLLEEMDEMGNWPPPE
Function: Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 40854 Sequence Length: 373 Domain: The N-terminal domain is required for targeting to the mitochondrion. Subcellular Location: Cytoplasm
E4PMA5
MLLKNAVQLICYPDRIGNNLKDLYTVVDTHLSEAIGGLHILPFFPSNADGGFSPLTHKEVDPKVGTWDDIEAFTAKYDLCVDLTVNHISDESPEFTDFIANGFDSEYADLFVHVDKFGEISPDDMAKIHIRKEKEPFREVTLSDGTKTRVWCTFTEQQIDLNYESDLAYQLMESYIGFLTSKGVNLLRLDAFGYTTKRIGTSCFLVEPEVYQILDWVNQVALKHGAECLPEVHDHTSYQYAISRRNMHPYGFALPPLLLYSLLDANSTYLKNWLRMCPRNMVTVLDTHDGICIPDVEGVLPDEKIKVLIDNIDARSADPIMRRSAANIHSVGAIYQLTCTFYDALMQNDDAYIAARAIQFFTPGIPQVYYVGLLAGCNDHELMEQSGELRDINRHYYTLEEVEQDIQKPVVQRLLSLMKFRSNYPAFDGHFELNYSNNSSVAMAWRHGDYYCHLFVDLNFKTVKVTYTDVETGETRHLEC
Function: Catalyzes the reversible phosphorolysis of 2-O-alpha-D-glucosylglycerol with retention of the anomeric configuration, forming alpha-D-glucose 1-phosphate and glycerol. Has most likely a catabolic role, either regulating the intracellular levels of glucosylglycerol, which acts as a compatible solute, or degrading it when the environmental conditions change. Cannot catalyze the phosphorolysis of sucrose or glucosylglycerate. Catalytic Activity: 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol Sequence Mass (Da): 54825 Sequence Length: 480 EC: 2.4.1.359
Q8ECL7
MHNIHRRHFLKAAGAVTAGLVTANIALNANASSVAPKPSSGKSVIGLIAPKMEVVRVGFIGVGERGFSHVEQFCHLEGVELKAICDTHQAVVDRAVEHIVKQKRPKPAVYTGNDLSYRELLNRDDIDIVIISTPWEWHAPMAIDTMESGKHAFVEVPLALTVEECWQIIDTAERTQKNCMMMENVNYGREELMVLNMVRQGLFGELLHGEAAYIHELRWQMKEINHKTGSWRTYWHTKRNGNLYPTHGLGPVSQYMNINRGDRFDYLTSMSSPALGRALYAKREFPADHERNQLKYINGDMSTSLIKTVKGRTIMVQHDTTTPRPYSRHNLIQGTNGVFAGFPNRIAVENDGFGTSYHKWDTDMQKWYDKYDHPLWQRIGKEAEINGGHGGMDFVMLWRMVYCLRNGEALDQDVYDGASWSVVNILSEQSLNNRSNSVNFPDFTRGAWEHAKPLGIVGA
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase that has specific alpha-N-acetylgalactosaminidase activity. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Catalytic Activity: Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids. Sequence Mass (Da): 51965 Sequence Length: 459 EC: 3.2.1.49
Q01S58
MDKTSRRDLLKLASLAGIGAGLARSQGSSKSMAGVSFKPNGTVRIGVIGTGGRGGSLIENFSAVEGVQITALCDTVKDKVLKQQAWLDKAGKASHPIALFHSDDHAFENLVKRDDVDLVVVSTPWVWHTRMAVAAMKQGKHVAVEVPAARTIDECWELVNTSEATQRHCIQLENCCYGYNEMMVLNMVRAGLFGELTHGGAAYNHDLRSILFSAEGEGEWRRFEHLNRDGNLYPTHGLGPVAHYMDVNRGDRFDTLVSMSSISASLQQYRKEKIPAGDPRQKEVYKEGDFNVSLIRTVKGRVIELEHNVSSPQPYDRINLIAGTKGIFRDYPPRIYFDGARREDFETLDRYKEKYEHPLWKKVGELAKELGGHGGMDFVMAYRLIQCMKEGTPPDIDVYDAAAWSAPGPLSEASVANGSAPQKFPDFTRGKWQTRQPV
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Sequence Mass (Da): 48656 Sequence Length: 438 EC: 3.2.1.-
Q9RK81
MSQTPAVSRRLLLGSAAATGALATGIGSAAPVAAAEQAPRRRPGQKSMIGVPFAAHPTVRVAVIGLGNRGGGMITGWAAVPGCTVTAVCDIRADRAERAADRLESKGNPRPAEYGGSADSYARMLRRDDIDLVYIATPWEFHYEHGRAALLSGRHAVVELPVATELRQLWDLVDTSERTRRHLLLSENCNYGRNELAMLKAAHDGLFGDLTNGHGGYLHDLRELLFSDTYYTDSWRRLWHTRSTASFYPMHGLAPIAAAMDVNRGDRMTTLRATTTAPKGLADYRARFVPRDHPSWKETYINGDLVTCMIETAKGRTVRAEHDVSSPRPYSRINTLAGSRGIVEDYAGSAPTGARIYVEPDHGGHTWRDFETYRKEYDHWLWQKVGDDAANNGGHGGMDYVLQWRTVQLMRAGLVPDIDVYDSAAWCSPVPLSVTSLARGGRPVEIPDFTRGAWRERRPGLDSAPTDMPPAG
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase (By similarity). Has no alpha-N-acetylgalactosaminidase activity. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Sequence Mass (Da): 51800 Sequence Length: 472 EC: 3.2.1.-
B2FLK4
MFAMKRREFIAASAAVAASSLLPQTPAWARGRKVRLAMIGTGMRGLVLLKELVRRDDVEVVALCDIEPIMLGRAMDMVAKAGKPAPKTYGQDRDTHAWKRLLEQKGIDGVIIATPWEYHAPMAIAAMQAGVAVGCEVVAGITLQDHWDVLKTQLSTGTPYMLLENVCYRRDVMAALQMVRQGLFGELVHLQAGYQHDLRGVKFNSGDPNQPYDSGVEFGPKGWSEARWRTEHSVERNGELYPSHGIGPCAMYTGINRGNRFTHINAFATKARGLHEYTVAKSGGTTHPSTKVKFKLGDIVTTTLACENGETILLQHDTSLPRPYSMGFRVQGTKGLWMDVNHSIHIEGRSPPHQWEEFKKYQDEYEHPLWKQNADTAASAGHGGMDWFVIHAFVEALKAKAPMPIDIYDAVTWSAITPLSEQSIANSFQTLEFPDFTAGAWKQRKPIFAFDGKY
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Sequence Mass (Da): 50486 Sequence Length: 454 EC: 3.2.1.-
Q50HM6
MNDAAPQNPGQDEAKGTGEKDNGGSMSPRSALRTTAGVAGAGLGLSALGTGTASASVPEAAQTAVPAAESDESAAPKRQGRTMAGVPFERRSTVRVGIIGLGNRGGSMIDLFLAVPGVRVVALCDTVRDKAASAAAKVVKAGQPAPAVYTKDEHDYEQLCARGDVDFVYVATPWDFHFEMAKTAMLNGKHVGVECPVAMRLDELWKLVDLSERTRRHCMQLENCAYGKNEMRVLRMAHAGLFGDLLHGAGAYNHDLRGLMFDPDYYEGPWRRLWHTRLRGDLYPNHGFGPVANYLDINRGDRAVSITSMGTPALGLAQYREENMPPGDASWKETYVSSDRTISLVQTAKGRVVRLEHDVSTPHPYSRINSLGGTRGVFEDYPERIYIEPDHANDEWGDFAAYADWDHWLWKEHANPPGGHGGMDYIMVFRLMQCVRLGLVPDFDVYDAATWTAPVPLSHASIKANGKPQQIPDFTRGEWKKSRPGTDSEKPSEP
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Sequence Mass (Da): 54036 Sequence Length: 494 EC: 3.2.1.-
A4Q8G1
MENTRRNFLKKVTAAGIGAAGLAVTDQAMAAVNQPGEAAQQKKKPAGKSDGMLRFGFIGTGSRCQEHINNVLGIQGNKIVAICDIQKGPLEKTLKHIAKFNVPEPKVYTGGEREFEKMLNNEEFDCVIIASPWEWHVPMAVAAMKAGVPYVGVEVSAANTVEECWDLVNVSEATGSHLNILENVCYRRDVMAALRMVREGLFGEMIHGTCGYQHDLRDVKFNDGIHYTYQEGGELRMGPTAYAEAQWRTQHSVTRNGDIYPTHGIGPVANCLNINRGNRFLSLTSMATQSRGLHNFVVDKGGANHPYAKIHFNLGDIVTSMIKCANGQTVIVTHDTNLPRPYSLGFRIQGTRGLWMNDGNHVYVEGQSKPHRWDASDDWFKKYDHKLWSTLELKAKEAGHGGMDYIMMYDFIDAIRNKKPTPMDCYDAAAWSAISGLSEMSIARGGAVVDFPDFTRGQWIHRQPAFAL
Cofactor: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Function: Glycosidase that has specific alpha-N-acetylgalactosaminidase activity. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Catalytic Activity: Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids. Sequence Mass (Da): 51923 Sequence Length: 468 EC: 3.2.1.49
E4Q361
MSFPKGFLWGAATASYQIEGAWNEDGKGESIWDRFTHQKGNILYGHNGDVACDHYHRHEEDVSLMKELGIKAYRFSTAWARIFPDGFGNINQKGLEFYDKLINELVENGIEPVVTLYHWDLPQKLQDIGGWANPEIVNYYFEYAMLIINRYKDKVKKWITFNEPYCIAFLGHWHGIHAPGIKNFKVAMDVVHNIMLSHFKVVKAVKENNIDVEIGITLNLTPVYLQTERLGYKVSEIEREMVNLSSQLDNELFLDPVLKGSYPQKLLDYLVQKDLLDSQKVNNMQQEVKENFIFPDFLGINYYTRSVRLYDENSGWIFPIRWEHPAGEYTEMGWEVFPQGLFDLLIWIKESYPQIPIYITENGAAYNDKVEDGRVHDQKRVEYLKQHFEAARKAIKNGVDLRGYFVWSLIDNFEWAMGYTKRFGIIYVDYETQKRIKKDSFYFYQQYIKENS
Function: Has high beta-D-glucosidase, exoglucanase, beta-D-xylosidase, beta-D-galactosidase, and transgalactosylation activities in vitro. Has a very broad substrate specificity with the highest activity with p-nitrophenyl beta-D-galactopyranoside (pNPGal) as substrate. Active with pNP-beta-D-glucopyranoside (pNPGlu), pNP-beta-D-cellobioside (pNPC), lactose, pNP-beta-D-xylopyranoside (pNPX) and cellobiose in the order of decreasing activity, respectively. Very low activity with soluble polysaccharides synanthrin and locust bean gum. Very low, but detectable activity with insoluble substrates such as cotton and filter paper. No activity with pNP-alpha-L-arabinofuranoside (pNPAr) or carboxymethylcellulose (CMC) as substrates. Synthesizes galactooligosaccharides (GalOS) from lactose. Hydrolyzes pretreated corn stover releasing both glucose and xylose. This multifunctional enzyme may provide C.owensensis the benefit of utilizing a wide variety of available carbon sources in its natural growing environment as the ability to convert a wide range of soluble oligosaccharides to monoses is required in order to assimilate them. Catalytic Activity: Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose. Sequence Mass (Da): 53195 Sequence Length: 452 Pathway: Glycan metabolism; beta-D-glucan degradation. EC: 3.2.1.21
Q6DB24
MKPSVILYKKVADDLRARLDQHFTVTELDAFPALDHPALATAEGIIGSGGKVDKDFLQHAPRLRAASTISVGYDTFNVDALNEKGVILMHTPTVLTETVADTVLALMLASARRVVEVVERVKAGEWKGGVGSDWFGTDVHHKTIGILGMGRIGLAVAQRAHFGFSMPVLYNARRHHAEAEERFNARHCDLDTLLAESDFLCITLPLTAETHHLIGREQLAKMKPSAILINIGRGAVVDEDALTEALVKGTIQAAGLDVFVKEPLPVDSPLLDLPNVVALPHIGSATHETRYDMAACAVDNLIAALSGQVKENCVNPQVLK
Function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Catalytic Activity: glycolate + NADP(+) = glyoxylate + H(+) + NADPH Sequence Mass (Da): 34549 Sequence Length: 320 Subcellular Location: Cytoplasm EC: 1.1.1.79
Q99JY3
MEVQCGGAGFIPESSRSSHELGNQDQGIPQLRIVLLGKTGAGKSSTGNSILGEKVFNSGICAKSITKVCEKRVSTWDGKELVVVDTPGIFDTEVPDADTQREITRYVALTSPGPHALLLVVPLGRYTVEEHKATQKILDMFGKQARRFMILLLTRKDDLEDTDIHEYLEKAPKFFQEVMHEFQNRYCLFNNRASGAEKEEQKMQLLTLVQSMVRENGGRCFTNKMYESAECVIQKETLRMQELYREELEREKARIRREYEEQIKDLRDELEREIRRARMEREFKEREAIFTKNQQNARKEVENTSMILELIIKAWEIASFIFNQFMKD
Function: During thymocyte development, may play a role in the regulation of apoptosis. PTM: Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis. Sequence Mass (Da): 38044 Sequence Length: 328 Subcellular Location: Cytoplasm
Q96F15
MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIFHYI
Function: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation . Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). Location Topology: Single-pass type IV membrane protein Sequence Mass (Da): 34846 Sequence Length: 307 Subcellular Location: Lysosome membrane
Q8BWF2
MEHLQKSTYGTIVQGPEAHCVQESSCLRILLVGKSGCGKSATGNSILRRPAFQSRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDAMAVRMVKEVFGVGVMRHMIVLFTRKEDLEEKSLEEFVTHTDNRSLRSLTQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAEALLREGYSVHQEAYRCYLAKVRQEVEKQRRELEEQEGSWIAKMICTVKSCWSSHTAACALLIVLGLTLLTTFINLCISRCK
Function: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes . Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation . Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function . May promote the survival of mature T lymphocytes upon cytokine withdrawal . May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues . Is a regulator of liver endothelial cell homeostasis . Location Topology: Single-pass type IV membrane protein Sequence Mass (Da): 34653 Sequence Length: 308 Subcellular Location: Lysosome
Q8K3L6
MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK
Function: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence. Location Topology: Single-pass type IV membrane protein Sequence Mass (Da): 37266 Sequence Length: 326 Subcellular Location: Lysosome membrane
G5ECR8
MSRWKVVILCLLSFMFEIGHASFQCNPKTYDGAFLNIVCVCNATFCDEIEPIGEIAEGKAIVYRSSLDGDRLKRMSMKMKEKLRKNESVNVTITIDASERFQNIFGFGGAFTDSAGDQFVSLSETLQNYIVDSYFGKNGLEYNIGRVPIASCDFSTHEYSYDDVHDDFELKHFALPDEDLKLKIPFIKKAIEKTEGNIQLFASPWSAPGWMKVTGRMRGGGAMRNDKRVYQAYADYFFKFFEAYSSHAITFWGLTIQNEPSTGADMAWRWQTMNYTAETMRDFLKKYLGPKLKENKLTETLKVMVLDDGRGLLPGWADTIFNDPEATKYADGVAVHWYGNLYSPAVLLDITQRHHPTKFIFGTEACAGYFGHHGPIMGDWFRAESYADDIITDLNHHVTGWTDWNLCLDETGGPNWAYNVVDSPIIVNRTAQEFYKQPMFYALGHFSKFLPRGSTRVFTKIEGNLAVSATSVVIEGGRRATVILSKASNSLLTRIVDSSTGFSIVLNLPPRSIHTVIWKKRK
Catalytic Activity: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose Sequence Mass (Da): 59088 Sequence Length: 522 Pathway: Lipid metabolism; sphingolipid metabolism. EC: 3.2.1.45
Q9UB00
MILNISVSLLIFLAFYGFSSDAKSLPCSEVKKEYGIVCRCNATYCDTIEPLGTVTSGKAVVYTTSRNGKRMNRSELKHTTSSTAKTKVYVNTTQSFQPVMGFGAAFTDAAGINMKMLPQTMQDQIIQQYFSDDGLGYVFGRVPMASTDFSTHEYSYDDVKFDFDLKNFNLTVEDLQYKIPFIKKAMTASGGKLKLFATPWSSPGWMKTSGRMVGAGELLGDQNGKYYQTWAQYFVKFFEAYHAQGIDFWSLTPQNEPTTGIDPLWKWQTLFFDASMERNFIKKLLGPALASSPVTKNLKIMINDDQRINLPHWPNVILTDPTAAQYVHGIAIHWYEDFIDPATVLTETHEKFPDYFLLATEACAGYFPADGPKLGSWSRAEQYANDLIKDMGNWVGGWVDWNYILDLQGGPNLAKNFVDSTIIVNATAQEYYKQPIWHVMAQFSKFVKPGAIRVGINIIEKSVDVEGLSFLNQDGTKTVVLLNKNEVLSFDVAISDVSAPNVIYDLTIQPNSLITIVYK
Catalytic Activity: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose Sequence Mass (Da): 58247 Sequence Length: 519 Pathway: Lipid metabolism; sphingolipid metabolism. EC: 3.2.1.45
Q9Y223
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIY
Function: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. PTM: Phosphorylated by PKC. Catalytic Activity: H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP Sequence Mass (Da): 79275 Sequence Length: 722 Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis. Subcellular Location: Cytoplasm
I7FJX8
MIELDRLDLGGGRRLVITSEPDAAVPQVRDADGHWRRAGPGDGVAEAMLDALNQNPGTTKHGNFTLLSWASQTARGERPITVDQTNESVIVGDAAVVKWATHLQEGPHPAPARIKALRGNGFRGMPMPWGLVTWQTADHPETLVVTVDEYLPDAVDGWTWAVALVTDAAQDRAAVPALVDAVTAVGCVVAELHAAQADTARPATAADARSWREAALETVETAATLGTSVSGELLRARREDVEAVVGTLGDLAGIPVLAGHGDLHVGQVLRAGGRYVVTDFDGNPVLPAEARVKPVPAALDVAGMAQSLAHVAIVACKYTELAPAALADVDRLARTTFVGAYTDRLETLGHRSVYDPAPLRALRLQQVLREIIYAARHLPRWMYVPDAALPALLDEGTST
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism. Is unable to phosphorylate maltose. Catalytic Activity: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+) Sequence Mass (Da): 42337 Sequence Length: 399 EC: 2.7.1.8
A0A1H7TQR5
MTPNWSELVAAADPALVLPSGERRAEVAVPGPLRLDALLDLGEGHAVGVVRSADAARWTVPLVRDGAGGVRRSRPGDGTAEHLVAALARRGATPDAAFVLEAFTGAAPVTGERGIIVDQTNESVIVGECAVVKWAVRLPAEGEPGSPAAQRIAALARGGFTEMPRPWGLLTLAEGAQPVLLASVVAYLPGALDGWDWAVDDVRRLARGELTMDQALLPAAQLGTLTARMHAALAARGRTPATAADVAAWGVRMREELDEAVASVPGAEGERLKAWAPRIADVYAELDALAGTPLIDVHGDFHVGQILRADGRYAVVDFDGNPVLPADQRAARQPAALDVVGMTASLDHVGRVVVFRTPDVDPAPVRAWIAAAQRSFLDAYRTTLARLDADDLFDDRLLTPLRYAQEVREYLYAVRHLPHWVYVPDLSLTDLLPERLKD
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism. To a lesser extent, is also active on glucose, but is unable to phosphorylate maltose, 18 other sugars and several aminoglycoside antibiotics. Catalytic Activity: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+) Sequence Mass (Da): 46730 Sequence Length: 438 EC: 2.7.1.8
O07563
MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVIIFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLLGYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYYCIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFFAFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKYLLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVTSLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPISLENKASKTQ
Function: Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44910 Sequence Length: 401 Subcellular Location: Cell membrane
A0A0H2VG78
MKANKYLIFILGALGGLLYGYDNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEEAARQVMKITYDDSEIDKELKEMKEINAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEIEYELRERTGARTE
Function: Transporter highly specific for glucose uptake. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 48375 Sequence Length: 446 Subcellular Location: Cell membrane
Q89YS5
MPATEKASAPHWSFLSSDVISIMKSNPSTLLLPLAALSLASCANPQKEETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACILTGKFSHENGFTDNASTFNGDQQTFPKLLQQAGYQTAMIGKWHLISEPQGFDHWSILSGQHEQGDYYDPDFWEDGKHIVEKGYATDIITDKAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFPEPANLFDDYEGRGKAAREQDMSIEHTLTNDWDLKLLTREEMLKDTTNRLYSVYKRMPSEVQDKWDSAYAQRIAEYRKGDLKGKALISWKYQQYMRDYLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFLGEHGWFDKRFMYEECQRMPLIIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPSDIQGASLKPVLENEGKTPADWRKAAYYHYYEYPAEHSVKRHYGIRTQDFKLIHFYNDIDEWEMYDMKADPREMNNIFGKAEYAKKQKELMQLLEETQKQYKDNDPDEKETVLFKGDRRLMENR
Function: Exosulfatase involved in the degradation of the glycosaminoglycan (GAG) heparan sulfate (HS). Catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units . GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract . PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Sequence Mass (Da): 64585 Sequence Length: 558 EC: 3.1.6.-
Q97UZ1
MKRKYPYSLAKGLTSTQIAVIVAVIVIVIIIGVVAGFVLTKGPSTTAVTTTVTSTFTTTTTIPSTTTSTPSNTVVFYTWWGGGDGGEALSQIIPAVKQYAGLQMQTYSIPGAGGTNAKYAILALIQAGKPPAAFQVHYGPEMISYVEAAPNGIHTFVNMTPYLIQWGLLNNAVYAVLQAGAYNGTLLSVPINVHRGAVLYVNTQLLREYNLPFPYNFSTLVYDTVQLANHGVSPWIIPGGDGGWDQFNVWEDIFLYLAGPQLYNELIYGTLNFSNPTVQKLINETNYWFLNFTSYNYPGWQSMSWEQAFALIAQGKVAFQANGNWVTNYASYINVTVYPPLPQYISNSSVSVVETPFPGTQHYYALVIDTIGIPVGPQEQQALQLAHFWSSYQGQEVWTKYKAVTYYKNGTDWYAQPAQWYDYQQLINTSEQNFVYQLSDGGVFDDVFAQIDSGLLTLQQVGKVGLSAWNSTLVSSMQQEQNEWLAAAKLGLGYLGFPGHPFAGYYPPWVTNPSAYGLTNNTQKTSNSVMLFLLPFLALPLAIASIDNKYYLLK
Function: Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Binds glucose. Can also bind galactose and mannose . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61128 Sequence Length: 554 Subcellular Location: Cell membrane
Q9VQC4
MAKRQTWEQMRQIFVQAVNAVHPEKVFADFQKFDLRPQIGENATDISIKLNGERQDISGKTCHIVGFGKAVLGMANKVQQDLGATSAGGVLSVPVNTLKQFQQPVAPGLVVHEGAANNLPDENALKAAREIKQLAEKMTAQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMKRGASIQEINAVRIACSDIKGGRLARLAGQAGLLVTFVLSDIIGDPLELIACGPTIQPEAAASPSDILKKHHVWEELSPEIRRVFEQPEEQKNTSLPEHKVFVVGSNVIATSTAAHEAERLGYIPCVLSCAVQGDVAQVAGDYQRLLHGIQEAKQHGILDPQLREKYAFGERSYPTFRRALEDHMSSKKPLFLICGGEPVIKVSGHGLGGRSQHLALLMSQALHRDEAMRDCTFLSAGTDGIDGPTDAAGAFGDSSVVESYLGDHTLDELAETLRNCDSYNFYKNLAQGEHHVLTGHTGTNVMDLHFLVVP
Catalytic Activity: (R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+) Sequence Mass (Da): 52792 Sequence Length: 487 Subcellular Location: Cytoplasm EC: 2.7.1.31
Q8IVS8
MAAALQVLPRLARAPLHPLLWRGSVARLASSMALAEQARQLFESAVGAVLPGPMLHRALSLDPGGRQLKVRDRNFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMERAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLSAAMQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEALETMAWGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGGTDGQDGPTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMTGTNVMDTHLLFLRPR
Catalytic Activity: (R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+) Sequence Mass (Da): 55253 Sequence Length: 523 Subcellular Location: Cytoplasm EC: 2.7.1.31
Q6MAS9
MHIIHIASELAPLAKVGGLADVVLGLCRELSWKGHDVDIIIPKYDCMDSEQIRDLTVDYFELPSFYNGEWFFNTVWMGWVENLKVYFIEPHHPRFFFNRGCFYGCEDDLERFLYFSRTALEFLYKKSILPDIIHLHDWQTAVIAPLYKDMYQKLGYTKPKILFTIHNMEYQGKCAAHDLNYIGLDGNRYQQHSFMQDNLYPHLINLLKGGIVYSDFVTTVSPNYAKEVLTPKEGRGLEATLVEYQHKFKGILNGIDYSYWNPEIDRFLPAHYSLREMPKNKKDRNTVDKKGFIKKILREKLYLAEEHRPIIGCITRLVPQKGIDLIKHTIRHIVEKKGQFILLGSSPIPSINDEFHRLKHQYTDHPHIHLILHHSEELAHLIYAGSDMFIVPSLFEPCGLTQIIALKYGTVPIVRRTGGLADTIIDVDHTDQQPDKKNGYVFDDPDANGIDSAIDRAIHCWFEEPEKWRQLMLNGMKMDFSWNQSSDCYLKIYQAISAKN
Function: Synthesizes alpha-1,4-glucan chains using ADP-glucose. Catalytic Activity: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) Sequence Mass (Da): 58201 Sequence Length: 500 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.21
Q6CZK3
MRVLHVCSELFPLLKTGGLADVAGALPGAQIAAGMDVRVILPAFPDLKKGIANLQVVRELDTFAGHVTLLFGHFNGVGIYLIDVPELYERAGSPYHDPALYAYADNYLRFALLGWMGCEMACGLDHYWRPDIVHAHDWHAGLTCAYLAARNRPAKSVFTVHNLAYQGLFAAGHMANLHLPSDFFQVYGLEFYGQISYLKAGLFYADHITTVSPTYAHEITLPAYGYGMEGLLKTREEEGRLSGILNGVDETIWNPTHDPLLTNHYSREALANKAENKRHLQTAMGLKVDDKAPVFAIVSRLTSQKGLDIALSAIPDLLEQGGQLVVLGAGDADLQEGFLAAAAEYHGQVGVQIGYHEAFSHRIIGGADVIMVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGLASGFVFNDCSVGSLSRAIRRVFVLWSRPTLWRYVQRQAMAMDFGWQVSAQAYGALYQRLHTH
Function: Synthesizes alpha-1,4-glucan chains using ADP-glucose. Catalytic Activity: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) Sequence Mass (Da): 52541 Sequence Length: 479 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.21
A9BG68
MKIAYVSYEVSPFAKAGGLADVAGALPKYIKNAGEDIYVVMPFHKNIENNYDISKFEVVKTGLIPDSHTHKSPFSVYKSYLEGSSVVIYFIKTDSLYDSKNIYDEENIFLKTSYFCDSALKTIKECEPDTNVININDWHTSLIPVYLKTHYLQDNILKKIATILTIHNIGYQGLFNPEVLNQAGLPNYLFNMNALEYYGKVNVLKGGILFSNIINTVSPTYAKEIQSEEYGYGLEGILKVRSEDLFGILNGIDYSIYDPLKDPHIFHPIESYEDKLKNKTSLQEYLGLTKDENITLISFIGRLFEQKGIDLISKIMDLLLLNDIQFVLLGTGDKKYEEYFVTLTKLYPKKISINITFDVDLAQKIYAGSDIFLMPSKYEPCGLGQMYSMRYGTVPVVRYTGGLKDTVSEYNPKDKKGTGFGFHEYKEADLLYTLMKAIYFHQKRKDDWTNIFENCMKEDFSYEKTAKKYIELYKIALDKKRGY
Function: Synthesizes alpha-1,4-glucan chains using ADP-glucose. Catalytic Activity: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) Sequence Mass (Da): 55456 Sequence Length: 483 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.21
A1VL96
MKVLHAAAEVYPLVKTGGLADVLGALPEALIGAGADVRLVLPGLPAILAGVEQQQVVHEIGAVFGAGRVTLRLGRLAHNGVPAYVIDAPYLYQRPGNPYLAPDGGEWPDNLQRFGLLGWVAAHLAAGELDPGWTPDVLHAHDWHAAMACAYAACHPATRAATVYTIHNLAYQGLFDEDDFHLLGLPSRLMVPVGLEFHGQLSFMKAGLKYAHRITTVSPTYAHEIATEAFGCGLDGVIRARGADVSGILNGVDGAVWNPASDPLIAAPYSADMLDGKALCKAALQRELGLAVDAGAPVFAVVSRLTSQKGLDLLLDALPALLNFPAAGGPQLAVQGNGDPALEAAFTAAAAAHPGRVAVRLVYDEALAHRIMAGADAMLVPSRFEPCGLTQLYALRYGTVPVVRHVGGLADTVVGASEASVQADRATGFMFGPATPAALAQALLQAVAAHGQPALWHRLMLRGMAQNFSWTAAASQYMALYRETQQAMQATGKL
Function: Synthesizes alpha-1,4-glucan chains using ADP-glucose. Catalytic Activity: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) Sequence Mass (Da): 51711 Sequence Length: 494 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.21
Q7VBP0
MRVLFAAAECAPMVKVGGMGDVVASLPSALAKLGHDVRLIIPGYSKLWGLLDISKDPIYTAQTMGAEFSVYETKHPTSNLPIYLVGHPVFDPERIYGGEDEDWRFTFFASATAEFAWNVWKPQVLHCHDWHTGMIPVWMHQDPEISTVFTIHNLKYQGPWRWKLERMTWCPWYMSGDHTMAAAMLFADRVNAVSPTYSREIRTSEYGESLEGLLNYISGKLRGILNGIDLDEWDPATDKALPANFSSGKMSTRKKNKEALQRQMGLEVNNDKYLLGMVGRLVDQKGVDLLLQVSRRLLAYTDSQIVVLGTGDQILESALWELAIDHPGRFAVFLTYDDYLSRLIYAGSDAFLMPSRFEPCGISQLLAMRYGSIPIVRNVGGLVDTVIPHDPINKSGTGFCFDRFEPIDFYTALVRSWEAFRHRRSWKELQKRAMTQMYSWERSAMEYETMYKEVSGYKEPSPDAIEVEKFSVGQDADPSLKNEKLSVGQDEDSSLKNERFI
Function: Synthesizes alpha-1,4-glucan chains using ADP-glucose. Catalytic Activity: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) Sequence Mass (Da): 56943 Sequence Length: 501 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.21
O84874
MDPFFLNTQHVELLVSGKQSSPQDLLGIVSESLNQDRIVLFRPGAETVFVELRGKIQQAESHHSGIFSLPVMKGISPQDYRVYHQNGLLAHDPYAFPLLWGEIDSFLFHEGTHQRIYERMGAIPCEIDGVPGVRFIVWAPHAQRVSVIGDFNGWHGLVNPLHKVSDQGVWELFVPGLTAGACYKWEMVTESGQVLIKSDPYGKFFGPPPWSVSVVIDDSYEWTDSEWLEERIKKTEGPMNIYEVHVGSWRWQEGQPLNYKELADQLALYCKQMHYTHVELLPVTEHPLNESWGYQTTGYYAPTSRYGSFEDLQYFIDTMHQHGIGVILDWVPGHFPIDSFAMSGFDGTPLYEYTRNPSPLHPHWHTYTFDYAKPEVCNFLLGSVLFWIDKMHVDGIRVDAVSSMLYLDYGRYAGEWVPNRYGGRENLDAIRFLQQFNTVIHEKYPGVLTFAEESTTFPKITVSVEEGGLGFDYKWNMGWMHDTLHYFEKDFPYRPYHQSDLTFPQWYAFSERFLLPFSHDEVVHGKRSLIGKMPGDAWRQFAQLRLLLGYQICQPGKKLLFMGGEFGQGREWSPGRELDWELLDISYHQGVHLCSQELNALYVQSPQLWQADHLPSSFRWVDFSDVRNGVVAYLRFADADAKKALLCVHHFGVGYFPHYLLPILPLESCDLLMNTDDTRFGGSGKGFREPEILTPEIARQEREAAGLIEADDESGPDCWGLDIELPPSATLIFSVTLQ
Function: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Mass (Da): 84651 Sequence Length: 738 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18
Q0TQ16
MRNCKELKHEKNGNVTEKIGKNKGKSKKVSKDESLLSFDLFLEGKEHSAYKFMGAHFVTENRKRGVRFTTWAPRSSKIYVIGDFNNWELKEEYSMKKINERGIWSLFLPKLEEGIKYKFAVVNECGNNTVYKADPYAFKSELRPNTASVLTKIKSFRWGDKRWLNKREKEGLDNKPMNIYELHLGSWKRKDGEFMTYEEISEVLVEYVKEMGYTHVEFMPINEHPLDASWGYQGVGYYSVTSRYGDLNGLKALINKLHKNNIGVLLDWVPSHFCKDEHGLFMFDGSPTYEYGAWWKANNEGWGTCNFDLGRPEVKSFLFSNAMYWINEFHIDGLRVDAVSNMLYLDYGREYGEWEPNIYGGNGNLEAIAFLKELNTIIKKEGKGAITVAEESTSWEGITKPVEEDGLGFDYKWNMGWMNDTLSYIELDPIYRKYHHNKMNFSMMYNYSEKFILPISHDEVVHGKKSLINKMWGDDWKKYAGLRLYASFMMGHPGKKLMFMGCEFGQFVEWREWEELQWNIIEEFDIHKKTQEYFKALNHFYLENSSLWSLDYEEEGFKWIDADNSEESVLSFIRIGKNKKEKLIFICNFTPEVYYDFKVGVPELGEYVEVFNSDSLEFGGAGNIMGDSILKATEESFKDFDYSIIVKVPPLGTLVLKVK
Function: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Mass (Da): 77008 Sequence Length: 659 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18
Q8NR40
MTVDPASHITIPEADLARLRHCNHHDPHGFYGWHETEAGSVIRTRQVGATQVNLLIDDTSHVMTPIGDDIFAIDLGHRERADYRLEVTWPDQEPQVKADPYYFLPTVGEMDIYLFSEGRHERLWEILGANIKTYQTALGTVRGTAFTVWAPNAIGCAVVGGFNGWNASQHPMRSMGGSGLWELFIPGIEEGEVYKFAVQTREGQRRDKADPMARRAELAPATGSIVASSEYQWQDSEWLRERSQTDLASKPMSVYEVHLGSWRWGKNYEDLATELVDYVADLGYTHVEFLPVAEHPFGGSWGYQVTGYYAPTSRWGTPDQFRALVDAFHARGIGVIMDWVPAHFPKDDWALARFDGEALYEHPDWRRGEQKDWGTLVFDFGRNEVRNFLVANALYWIEEFHIDGLRVDAVASMLYLDYSREHGEWEPNIYGGRENLEAVQFLQEMNATVLRLHPGALTIAEESTSWPGVTAPTWDGGLGFSLKWNMGWMHDTLEYFSKNPVHRAFHHSELTFSLVYAFSERFVLPISHDEVVHGKGSLWDRMPGDTWNKAAGLRTFLAYMWSHPGKKLLFMGQEFGQREEWAEGQGLPWDIVDGWQGEYHEAIRTLTRSLNGVYSDSPALHTQDFTGEGFTWNKGDDATNNILAFTRFGSDGSQMLCVFNLSGTSQPEYQLGVAAGGEWKLVLNTDDAEFLGAENDIATSVQAAATPRDNFAYSLSLHVPAMSAQFYSLQK
Function: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Mass (Da): 82593 Sequence Length: 731 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18
Q6A8Q7
MAHDEFGGLTGWDLEGFHSGGDTEVWKRLGSHVVTIDDDERGPITGTRFAVWAPNAQAVEVISDFNWWTGDRMRLIPGSGVWGTFVEGVDEGTLYKFRIQDQWGTWHEKVDPMARYSEQAPQNASIVTETHYEWNDDEWIARREASRAHAEPMSVYEVHLGGWRHGLSYRELADQLVSYVTWQGYTHVEFMPLAEHPFAPSWGYQVTGYFSPTSRYGSPDDLRYLIDKLHQAGIGVIMDWVPGHFPKDDWALGRFDGTALYEHADPRQGEHKDWGTYIFNYGRNEVKSFLVSSALYWISEFHADGLRVDAVASMLYLDYSREEGQWVPNKYGGRENLEAIDFLRYVNSHLYSRHPGILMIAEESTSFPGVTKPVDDGGLGFGFKWNMGWMNDSLRYLELNPFHRQYHHGEMTFAMVYQYSENFILPISHDEVVHGKGSMITKIPGDDWQQFASLRAFYSYMWSFPGKQLVFMGQEFGQRHEFDESVSLEWFVADLWGHGGLKRLFRDLNKIYKENPALWQLDSDPRGFEWINADDAGNNLFSWLRRSDDGSTIACFTNFSPNPQTDYRIDLPMEGVWTEILNTDSLEYDGTGEFGNLGQIVAAPLPAPDRLRAVATVCVPPMGSVWLRHNPSATAALPGDPGVQ
Function: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Mass (Da): 73563 Sequence Length: 644 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18
P32775
MYNIPDNVKGAVEFDPWLKPFADVLSERRYLADKWLYDITHATPDGSYQSLSKFARDSYKSYGLHANPETKEITYKEWAPNAERAFLVGDFNNWDTTSHELKNKDEFGNFTITLHPLPNGDFAIPHDSKIKVMFILPDGSKIFRLPAWITRATQPSKETSKQFGPAYEGRFWNPENPYKFVHPRPKFSESVDSLRIYEAHVGISSPEPKITTYKEFTEKVLPRIKYLGYDAIQLMAIMEHAYYASFGYQVTNFFAASSRFGTPEELKELIDTAHSMGILVLLDVVHSHASKNVEDGLNMFDGSDHQYFHSISSGRGEHPLWDSRLFNYGKFEVQRFLLANLAFYVDVYQFDGFRFDGVTSMLYVHHGVGAGGSFSGDYNEYLSRDRSFVDHEALAYLMLANDLVHEMLPNLAVTVAEDVSGYPTLCLPRSIGGTGFDYRLAMALPDMWIKLIKEKKDDEWEMGSIVYTLTNRRYGEKVVAYCESHDQALVGDKTLAFWLMDAAMYTDMTVLKEPSIVIDRGIALHKMIRLITHSLGGEAYLNFEGNEFGHPEWLDFPNVNNGDSYKYARRQFNLADDPLLRYQNLNEFDRSMQLCEKRHKWLNTKQAYVSLKHEGDKMIVFERNNLLFIFNFHPTNSYSDYRVGVEKAGTYHIVLNSDRAEFGGHNRINESSEFFTTDLEWNNRKNFLQVYIPSRVALVLALKE
Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Mass (Da): 81116 Sequence Length: 704 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18
Q9KRB5
MAGVLGMILAGGEGSRLKPLTETRTKPAVPFGGSYRLIDFALNNFVNADLMRIYVLTQFKSQSLYIHMKKGWNLSGITDRFIDIIPAQMRDGKRWYEGTADAIYQNLRFVEIVAPDQVCIFGSDHIYKMDIRQMLDFHRRMEAELTVSALRMPISQASQFGVIEVDENGKMVGFEEKPSNPKSIPGEPEWALVSMGNYIFEAETLSKELREDAENNQSSHDFGKDIIPKMFPRGKVYVYDFTTNKIKGEKESTYWRDVGTIESYWSAHMDLLDKDPEFSLYNRSWPLHTYYPPLPPATFVDVKDKKVKITDSLISGGSYIQGSTIYKSVLGFRSNIAAGSFISESVILGDVKIGAGCTIKRAIIDKDVEIAAGTIIGEDLEMDRKRFHVSDEGIVVIAKGSKVGF
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Catalytic Activity: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate Sequence Mass (Da): 45497 Sequence Length: 405 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.7.7.27
Q9KLP4
MQDTLAVILAGGMGSRLSPLTDDRAKPAVPFGGKYRIIDFTLTNCLHSGLRRILVLTQYKSHSLHKHLRNGWSIFNPELGEFITVVPPQMRKGGKWYEGTADALFHNMWLLARSDAKYVVVLSGDHIYRMDYAAMLEEHISKNATLTIACMQVPRHEASAFGVMAIDDDSRITCFVEKPADPPCIPNRPDHSLASMGIYIFNMDVLKKALTEDAEIEQSSHDFGKDVIPKLIATGSVFAYSFCSGKGRVARDCYWRDVGTIDSFYDANMDLLQPVPPMNLYQKNWAIRTYEQQYPPARTVSSATGNEGIFINSIIANGVINSGGSVQHSIISSNVRINDSALIVDSILFDDVEVGEGCKLIHCIIDKHVKIPPYTEIGLNPIEDRKRFHISERGVVVVPESYQFSTE
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Catalytic Activity: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate Sequence Mass (Da): 45372 Sequence Length: 407 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.7.7.27
Q2RS49
MDQITEFQLDINRALKETLALVLAGGRGSRLRDLTNRESKPAVPFGGKYRIIDFPLSNCMNSGIRRMCVITQYRAHTLIHHIQRGWGFLRAEIGEFVELWPAQQQTDKESWYLGTADAVHQNLDLIRMHDPRFVLILAGDHIYKQDYSKLLAHHIARGSDCTVACVDVPREEATGYGCVEVDNDDNIVHFLEKPANPPGIPGRPDRAFASMGIYIFNADFLYEILESDALNEASQHDFGRDIIPSQVGKARIVAHRFSQSCVYSVGRREPYWRDVGTVDAYWSANIDLVSVTPALDLYDADWPIWTYQMQRPPAKFVFDTDERRGMAKDSLVSAGCIVSGGAVTGSLLFNDVRVNSYSSVIDTVILPMGDIGRHARLTKCILDTGCRIPEGLVIGEDPILDAKRFHVTEQGITLVTPDRLALL
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Catalytic Activity: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate Sequence Mass (Da): 47376 Sequence Length: 423 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.7.7.27
B7K5U7
MKKVLAIILGGGAGTRLYPLTKLRAKPAVPLAGKYRLIDIPLSNCINSEILKIYVLTQFNSASLNRHLTRTYNFTGFSDGFVEVLAAQQTAENPKWFQGTADAVRQYLWAFQEWDIDEYLILSGDHLYRMDYRDFIQRHRETGADITLSVVPIDEERASSFGLMKIDDHGRVVDFSEKPKGDELKQMQVDTTVLGLTPEQAKESPYIASMGIYVFKKEVLAQLLEENPDQTDFGKEIIPFSAKDYNLQAYLFKGYWEDIGTIKAFYEANLALNRQPSPRFSFYNEEYPIYTRSRYLPPTKALNCTITESMVSEGCILKDCRIHNSILGIRTRIEANCTIEDTMLMGADYYESPSLRESKAQEGKIPMGIGEGSTIRRAIVDKNARIGRNVTIVNKENIDESNQEESGFYIRNGIVVILKNATIADGTVI
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Catalytic Activity: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate Sequence Mass (Da): 48547 Sequence Length: 429 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.7.7.27
Q21M27
MLDPNSRYVSRLTRDTVALVLAGGRGSRLHELTDWRAKPALHFGGKFRIIDFPLSNCVNSGIRRIGILTQYKAHSLIRHVIRGWSSFKKEFGEYVEILPASQRYSPNWYQGTADAIYQNLDILQAEAPKYILVLSGDHVYQMDYGAIIAHHVETGADLTVSCIEVPIEEAAGSFGVMTVDDDNRIIRFDEKPQRPTELANKPGYTLASMGNYVFNTEFLFDQLRKDAADPDSEHDFGKNIIPNIIAEKLVSAYRFRDHDTNETAYWRDVGTLDSFWEANMELVSPNPSLNLYNHDWPIWTYQTQLPPAKFVFDDDSRRGYAVDSMVSGGCIVSGGKVKSSLLFSDVHIHSYAEIEESVLLPEVEVHRSAKIKKAIIDSACVIPEGMIIGHDHEHDKARGFRVTKKGVTLVTREMLGQQPAGTSAK
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Catalytic Activity: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate Sequence Mass (Da): 47762 Sequence Length: 425 Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.7.7.27
A6TF50
MTSLAAGKPAPLGASYDGKGVNFALFSAHAERVELCVFDEQGNEQRFDLPARSGDIWHGWLAAAGPGLRYGYRVHGPWDPAQGHRFNPAKLLIDPSAHRVEGDLPDDERLHGGMWQPDRRDSAAVAPKSQVVDLRYDWRGDKPPRTPWGETVIYEAHVKGLTLLNPQLPEAIRGTYKALGHPAMIAYFKSLGISALELLPVAQFASEPRLQRMGLSNYWGYNPLAWFALDPRYASDPDRALDEFRDAVKALHAAGIEVILDIVLNHSAEIDLEGPTVSLRGIDNRSYYWVREDSDYHNWTGCGNTLNLSHPGVVEWARQCLRFWVDECHVDGFRFDLASVMGRTPEFRQDAPLFEAIRRDSVLSQVKLIAEPWDIGPGGYQVGNFPPLFAEWNDHFRDSARRFWLQQNVSLGDFAQRFAASSDLFARDGKPPSATVNLVTAHDGFTLRDCVCFNQKHNEANGEENRDGTNNNYSNNHGIEGLEANFAVIERRRASAHALLTTLLLAQGTPMLLAGDEQGHSQHGNNNAYCQDNALTWLDWRQANPGLTAFTAALIHLRRRIPALTRNRWWQEGDGNVRWLNRNAQPLTAAEWQQGAACMQIQLSDRWLLTLNATAEVVDMVLPEGEWRAVPPFAGEDNPVIMAVWHGPAHGVCVFQRS
Function: Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin. Catalytic Activity: Hydrolysis of (1->6)-alpha-D-glucosidic linkages to branches with degrees of polymerization of three or four glucose residues in limit dextrin. Sequence Mass (Da): 73651 Sequence Length: 658 Pathway: Glycan degradation; glycogen degradation. EC: 3.2.1.196
Q8YDC6
MQAIIDAEQSFKFPVLVGDIGGTNARFSILVDSNAEPKEFPVLQTADYATIDEAIQHAILDQTAIQPRSVILAVAGPVDGDEIDLTNCDWVVRPKKMIADLGFEDVTVLNDFEAQALAVVSLEGHHMEQIGGKPEEAVATRVVLGPGTGLGVAGLVCTRHAWVPVPGEGGHIDIGPRTERDYQIFPHIERIEGRVTGEQILSGRGLRNLYLGICAADKITPTLETPVDITSAGLDGSNPQAAETLDLFATYLGRLAGDLALIFMAHGGVYLSGGIPVRILSALKAGSFRAAFEDKAPNKAIMRDIPVRVITYQLAALTGLSAFARTPSRFEVSTEGRRWRMRR
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 36919 Sequence Length: 343 Subcellular Location: Cytoplasm EC: 2.7.1.2
Q62HW8
MSTGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRKYLKDAKIGRVNHAAIAIANPVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLIPADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHAGDALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPAFLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVNIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAAPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKD
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Location Topology: Single-pass membrane protein Sequence Mass (Da): 68376 Sequence Length: 641 Subcellular Location: Membrane
Q9A6N3
MDGNHSGGLGLVGDIGGTNARFALVEFDGQDPRLIEPTAYRGEDYGTAEDAIEEYLRKVGVKHPDQAVVAVAGPIDHGQVHMTNLDWRISEDGLRRAGGFRNAKLINDFTAQALAAPRVGPKDLRQIGELPTSGEGDLAILGPGTGFGVAGLVRRHGQEIPLATEGGHVAFAPVDDVEIEVLRALTRRLDGGRVSVERILSGPGMEDLHVDLAAAEGRGVEALTAKQITERAVEGCADSLATVNRFCAILGSTAGDIALTLGARGGVFIAGGIAPRIIDILEKSPFRERFDSKGRLSGFTRSIPTHVILHPHTALIGAAVALTPEGRAAVS
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 34714 Sequence Length: 331 Subcellular Location: Cytoplasm EC: 2.7.1.2
Q1QZ16
MTRPALIGDIGGTNARFALVTPGAFDLHDIRTLPCAHYPSLSDAIRAYLKEVGAEMPTEACLAFACPVHDDEVRMTNNAWRFSKRQVAEEFGFTLFKVINDFTAQALGVPHVADDELVALGDGEAAPGCTRLIFGPGTGLGMAGLFPGQHDWIPLPTEGGHISFAPTDQHERDLLAYFQARYGRVSVERILCGQGLLDLYRAHAQLAKQVARYNTPAEVTGAARAGDPLARNALERFLKILGDVSGDAALMLGARGGVYLCGGILPRLLDWLPHSHFRDAFADKGRMHAYTAHIPVWVVTAPWNGLLGACEALHNEEVT
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 34536 Sequence Length: 319 Subcellular Location: Cytoplasm EC: 2.7.1.2
Q7P1R6
MSTGLPEAWPRLLGDVGGSNARFALETAPGVIEDILTLSNERYPTLEDALRDYLAQVGARRVAHAAIGIANPLNGDLVRMTNCHWSFSIEATRRALGLSTLLLLNDFTALALALPRLPRRELAQVGGGAPRPDAPLALIGPGTGLGVSALVPHAGGWRALAGEGGHTSFAPANEREIGIWRYASARFGHVSHERLLSGSGLSLLHRALCALDGAEEAGLAPAEVSARGLSGADARCREALEIFCALLGSAAGNLALTLGARGGVYIGGGIVPRLSGFFEQSPFRRRFEDKGRMSAYLADIPVYLITSAYPALPGVAAHLADHLAPRSDPAPVAAPTHPRGGTAGDMHA
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 36267 Sequence Length: 348 Subcellular Location: Cytoplasm EC: 2.7.1.2
Q47XU3
MKNSQDTQVINLVADIGGTNIRLAITDKDNNINEIKTYQCKDFPHLSNVIYHYLKENGLLNSQVNACLAIACPVDTDSISMTNLPWKFSQKQLKEELKLHSLTLINDYTAIAMAIPLLSDKQKVKIGHGEAENKQPIAVCGPGTGLGVANLVNINNHWYCLGGEGGHTDFAPVDELDVKIFQQLKTTKKRLSYEQLLSGYGLEQIYQALVIINNQEATNAEQSKLSAKEISTQAIAGTCPICQQALSQFCKILGSFSGNLALTTGSFGGVYIAGGIVPRFIDYLKNSEFRARFETKGRMSHLNEQIPTYIITESQPGLLGAAAYLNQVFP
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 36201 Sequence Length: 330 Subcellular Location: Cytoplasm EC: 2.7.1.2
P21908
MEIVAIDIGGTHARFSIAEVSNGRVLSLGEETTFKTAEHASLQLAWERFGEKLGRPLPRAAAIAWAGPVHGEVLKLTNNPWVLRPATLNEKLDIDTHVLINDFGAVAHAVAHMDSSYLDHICGPDEALPSDGVITILGPGTGLGVAHLLRTEGRYFVIETEGGHIDFAPLDRLEDKILARLRERFRRVSIERIISGPGLGNIYEALAAIEGVPFSLLDDIKLWQMALEGKDNLAEAALDRFCLSLGAIAGDLALAQGATSVVIGGGVGLRIASHLPESGFRQRFVSKGRFERVMSKIPVKLITYPQPGLLGAAAAYANKYSEVE
Catalytic Activity: ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Sequence Mass (Da): 34897 Sequence Length: 324 Subcellular Location: Cytoplasm EC: 2.7.1.2
Q89DN1
MSRKYFGTDGIRGRANGLITPELALKVGQAAGLAFQRGDHRHRVVIGKDTRLSGYMIEYAMVAGFTSVGMDVLLVGPMPTPAVAMLTKSMRADLGVMISASHNLFEDNGIKLFGPQGFKLSDDVEKQIEQLLDEPIDKRLAQSASLGRARRIDGVHDRYIEFAKRTLPRDLSLDGLRVVVDCANGAAYKVVPEALWELGADVVPIGVEPDGFNINKDCGSTSPEALSKKVREMRADIGIALDGDADRVILVDERGHVVDGDQLLAVIAQSWKEDGRLSRPGIVATVMSNLGLERFLKGQGLDLVRTPVGDRYVLEQMLSGGYNLGGEQSGHIILSDYATTGDGFVAALQVLAVVQKSRRPVSEVCHRFDPLPQILKNVRHKGGKPLDDSDVKSAISDGEKRLNGHGRLLIRSSGTEPVIRVMGEGEDRILVEDVVDTIVSALGQAAA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 48276 Sequence Length: 447 EC: 5.4.2.10
C0ZIM8
MGKYFGTDGVRGVANTQLTPELAFKIGRVGGYVLTRHKQEGKPKVVIGRDTRISGQMLENALLAGLLSVGAEVVRLGVISTSGVAYLTRALGADAGVMISASHNPFPDNGIKFFGSNGFKLSDEVEAEVEQYLDAAEDTMPRPTGEQIGTVLEFLEGGQKYLSHLKSTVSERFDGLKVVLDCANGAVSSLAARLFADVDAEVITIGANPNGININDQCGSTHPERLVEEVLKHKADLGLSFDGDADRCIAVDNNGEIIDGDYIMAICARALKAKGKLNNNTVVTTVMANMGFFKGMEECSINTTKTAVGDRYVVEEMLRGGYNLGGEQSGHIVFLDYNTTGDGLLTGLQLLNIIKESGKPLSELKQVMVKYPQLLINVRVEDKSKLNGNEAIAQAIREVEEDLAGNGRVLVRPSGTEPIVRVMAEGPDAAQLEGLVNRIVDVVKQQLV
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 47996 Sequence Length: 448 EC: 5.4.2.10
Q8Y5E6
MGKYFGTDGVRGVANSELTPELAFRLGRMGGYVLTRHVGEHPRVLVARDTRISGEMLESALIAGLVSVGIEVMRLGVISTPGVAYLTKAQGASASVMISASHNPVDDNGIKFFGSDGFKLSDDQEEEIEQLLDTAEDTLPRPSGEGLGTVSDYFEGKQKYIQYLKQTIENDFNGYHIALDCANGATSGLATHLFADLDADISSMGASPNGLNINDGVGSTHPEALAAFVLDKKADVGLAFDGDGDRVIAIDEIGQIVDGDKIMFICAKYLREQGLLNNNTIVSTVMSNLGFYKGLKELEIEDVQTAVGDRYVVEAMREGNYNLGGEQSGHIIFLDHNTTGDGLLSGIQLINVMKATGKKLSELAAEMKTFPQKLENIRVSDKNHVTDNPKVSKVIDEVEAEMAGNGRVLVRPSGTEPLVRVMVEAATKEETDEYCERISAVVRSEMALND
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 48488 Sequence Length: 450 EC: 5.4.2.10
C4XU39
MDNKLFGTDGLRGRVNAYPMTPDVVMRLALSAGLHFRNGSRRHKVLIGKDTRRSGYIYEYALSSGFCAAGMDVFLTGPLPTPAISFLTRDMRADVGVVISASHNPACDNGIKFFDHMGFKLPDAVEAEIAARVEGYAQDWRLPDPDHVGRAFKLEDSPGRYNVFLKNSIPLDVNFEGLKIVLDCAHGAAYRVTPQVFEELGAKVIKIGVDPDGSNINQRVGSLFPQQVARMVAEAEADIGIALDGDADRVIVADEKGRILDGDQIMAICALDLMERGALPGNLLVATVMSNMALEVFMKDHGGRLLRTPVGDRYVVEAMRAQGAVFGGEQSGHLIFLNHSTTGDGTLAALQLMKIMVRKGKPLSELATLLSPFPQKLVNVPVARKIPFSEAPAIEAAVKDAEATLSGRGRVLLRYSGTESLARVMVEAQDAALVESLCDSLAEVVARALA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 48501 Sequence Length: 450 EC: 5.4.2.10
Q027B2
MAKDLFGTDGIRGVAGQYPLDRDTVYAFGVALGKDAALHAAKPEILIGADTRESGTWIAELVAGGLASQGAQVRYAGVITTPGVAYLTRTGSFVAGVMISASHNPYDDNGLKVFGHSGFKLPDDEELLIEQEIFRLREAPVAPQPLSLTVEEPLVRQYLKYLSGISSVRLDGVRVAIDCGNGASYRLAPELFQGLGADVVTICCEPNGRNINLNCGALHLEALQQAVVAHRAHFGVAFDGDADRAIFVSSSGQVVNGDAVLLACGRALKAAGKLAGNTVVSTVMSNLGLERAFDAAGIRMVRTPVGDKYVLEEMVRLGAALGGEQSGHVIFREYSTTGDGMLTALRLFEIAQQAGTGLDELTADLKIYPQRLVNVRVREKKGLLELPAVAKEIRRVEDAFGGAGRVLVRFSGTEPLARVMVEGPNLEQVESFSTSIADVIRREMGE
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 47468 Sequence Length: 446 EC: 5.4.2.10
A9G862
MPKHTKKDPREGAPSATGEPQKQAAGRKLFGTDGVRGVANQPPMTPEMALRLGRAIAFVASHGKSRQVRVVIGKDTRLSGYMLETAIASGVCAMGGRVMLSGPIPTPAVAQLTQSMRADAGVVISASHNPYQDNGIKIFGPDGYKLPDTAEEEIERLMESHELDEARVVGAAIGSAVKLDDARGRYVVFCKNTFPTALSLDGVKIVVDAAHGAAYRVAPSVFTELGANVTALGVKPNGRNINRETGALHPEHVKAEVLKRGAAIGIALDGDADRVIMVDERGEVVDGDAIMALCALRMLRTGKLPRNTIVTTVMSNLGLERALKAQSGHVVRTAVGDRYVVEAMRNGGYSFGGEQSGHLIFLDHATTGDGIVAALQVLAIMMEEDKPLSELASKAMQRVPQVLENATFATRLPLDSMQRTRVTVDRIEKTLGDKGRILVRWSGTEPKLRVMVEGEDASTIGAYALEIIEAAKQDVAGASA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. PTM: Activated by phosphorylation. Catalytic Activity: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate Sequence Mass (Da): 51042 Sequence Length: 480 EC: 5.4.2.10
O26273
MCGIVACILKDGSAAPVLLECVRRLEYRGYDSVGIATSDPMIRIKKDSGKIDEVDAELDLADLPGTMGIAHVRWATHGLPTAENAHPHTDCSGEIAVVHNGIIENYLEVKEELESEGHIFRSETDTEVIPHLIEKYMDEGMDLEAATATALRKLRGAYAIAAVSSREPGRIVGARKESPLIVGVGEGEYFLASDVPAILNHTSRVIYLDDGEMVILDGDLRVTDMEGNTVEKEVHSIDWSADMAEKGGYDHFMLKEIHEEPSAVRDTLTEWDEVLGVVEEIGEVERICFVACGTSYHASLVGKYLFESLLGIPTDVILASEFRYSAGALNDRTLAIFISQSGETADTLNALRAANSRAKTLAIVNVLGSSATREAQHVLYTRAGPEIGVAATKTYVSQLTVIYMLVAAMGAPELMDRLERVPEFMERALEDEDGIKELAATCSDVSDFFFIGRGFAYPTALEGALKLKEITYIHGEGYAAGELKHGPLALIDNGVPVVAISPPGPCHDKTLSNVEEVRARGARVIGVGSISDESLRKEADDFIGLDPEVDDVISPLVYIVPLQLLSYHVSVERGLDPDKPKNLAKCVTVE
Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Catalytic Activity: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate Sequence Mass (Da): 63995 Sequence Length: 590 Subcellular Location: Cytoplasm EC: 2.6.1.16
O68956
MCGIVGYVGHRPARDIVVDALRRMEYRGYDSAGIALIDGNGGLTVRRRAGRLANLEATLAETDSNDGDGLGGSTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAPLRAELEAAGVEFASDTDTEVAVHLVARQYTQGDTAGDFPASVLAVLQRLEGHFTLVFASADDPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRDAVELGQDQAVVLTADGYRITDFAGNDHLEAGRDFREFHIDWDLNAAEKGGYDYFMLKEIAEQPSAVADTLLGHFDKNRIVLDEQRLSDQELREIDKVFIVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVIAISQSGETADTLEAVRHAKTQKAKVLAICNTNGSQIPREADAVLYTRAGPEIGVAATKTFLAQIAANYLVGLALAQARGTKYPDEVAREYRELEAMPDLIKRVLAGMDSVAALAERFAPSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDENLPVIVVMPSPKNAAMLHAKLLSNIREIQARGAVTVVIAEEDDDTVRPYADHLIEIPSVSTLFQPLLSTIPLQVFAAGVARARGYDVDKPRNLAKSVTVE
Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Catalytic Activity: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate Sequence Mass (Da): 67903 Sequence Length: 628 Subcellular Location: Cytoplasm EC: 2.6.1.16
Q9K1P9
MCGIVGAIRAHHNVVDFLTDGLKRLEYRGYDSSGIAVNTDGKIKRVRRVGRVQLMEDAAREKGISGGIGIGHTRWATHGGVTEPNAHPHISGGMIAVVHNGIIENFESERKRLEGLGYRFESQTDTEVIAHSINHEYAQNGGRLFEAVQEAVKRFHGAYAIAVIAQDKPDELVVARMGCPLLVALGDDETFIASDVSAVIAFTRRVAYLEDGDIALLASDGIKRLTDKNGLPAERKVKVSELSLASLELGLYSHFMQKEIHEQPRAIADTAEVFLDGGFIPENFGKDAKSVFESIRSVKILACGTSYYAALTAKYWLESIAKIPSDVEIASEYRYRSVIADSDQLVITISQSGETLDTMEALKYAKSLGHRHSLSICNVMESALPRESSLVLYTRAGAEIGVASTKAFTTQLVALFGLAVTLAKVRGLVSEEDEARYTEELRQLPGSVQHALNLEPQIAAWAQQFAKKTSALFLGRGIHYPIALEGALKLKEITYIHAEAYPAGELKHGPLALVDENMPVVVIAPNDSLLDKVKANMQEVGARGGELFVFADLDSNFNATEGVHVIRAPRHVGKLSPVVHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE
Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Catalytic Activity: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate Sequence Mass (Da): 66619 Sequence Length: 612 Subcellular Location: Cytoplasm EC: 2.6.1.16
Q6CYJ9
MCGIVGAVAQRDVAEILLEGLRRLEYRGYDSAGLAVVDSEGHVARLRRLGKVQVLSQAAEEHELHGGTGIAHTRWATHGEPSEENAHPHISEHITIVHNGIIENHEPLRELMIGRGYRFVSETDTEVVAHLVHFEQKQNGGTLVEVVKRVIPQLRGAYGMVVLDNRDSSVLVAARSGSPLVIGRGVGENFIASDQLALLPVTRRFMFLEEGDVAEITRRDVRVFDKSGQLATREEIESKVSYDAGDKGAYRHYMQKEIYEQPMAIKNTLEGRFSHGEINLSELGPKADELLAKVEHVQIIACGTSYNSGMVSRYWFEALAGIPCDVEIASEFRYRKPAVRKNSLMITLSQSGETADTLAALRLSKELGYLGSLAICNVAGSSLVRESDMALMTKAGVEIGVASTKAFTTQLTVLLMLVARVGRLRGMDAQIEHDIVHGLQALPARIEQMLSQDKLIESLAEGFSDKHHALFLGRGDQYPIAMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPNNELLEKLKSNIEEVRARGGELYVFADEDAGFTSSENMKIIPLPHIEEVIAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE
Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Catalytic Activity: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate Sequence Mass (Da): 67000 Sequence Length: 610 Subcellular Location: Cytoplasm EC: 2.6.1.16
Q9HT25
MCGIVGAIAERNITPILIEGLKRLEYRGYDSAGVAVFDNEGRLQRCRRVGKVASLEEGLAGTPLLGRLGIAHTRWATHGAPTEGNAHPHFSSDEVAVVHNGIIENHEPLRERLKGLGYVFTSQTDTEVIVHLLHHKLQSIGDLTLALKDAVKELHGAYGLAVISAAQPDRIVAARSGSPLVIGLGLGENFLASDQLALRQVTDRFIYLEEGDIAEIRRDSVRLWDVQGNDVQRETVQYHEGAEAADKGEYRHFMLKEIHEQPSVVQRTLEGRLGQNQVLVESFGPQAAELFAKVRNVQIVACGTSYHAGMVARYWLESLTGIPCQVEVASEFRYRKVAVQPDCLFVTISQSGETADTLAALRNAKELGFLSSVAICNVATSSLVRESDLTLLTQAGPEIGVASTKAFTTQLVALLLLTLGIGQVQKRLADGVEAELVDELRRLPTRLGEALAMNRTVEKVSELFAEKHHTLFLGRGAQFPVALEGALKLKEISYIHAEAYPAGELKHGPLALVDSDMPVVTVAPNNELVEKLKSNLQEVRARGGELVVFADEGAGIEAGEGTHVVGMPHIGDVLSPILYTIPLQLLSYHVAVLKGTDVDQPRNLAKSVTVE
Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Catalytic Activity: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate Sequence Mass (Da): 66295 Sequence Length: 611 Subcellular Location: Cytoplasm EC: 2.6.1.16
A4XIS1
MSKKSTFIILAAGEGKRMKSKYSKVVQKIMGKPMILYIIDEIEKNFEDGRIVVVVGNKKEDVYKVLEGRNVRFAYQEKQLGTAHAVMCAMSEISDDSEDVFVLYGDVPFIKADTLKKLSQKRKEEAAALCLLTAIFENPYGYGRIIADENGNVLKIVEERDATEEQRKIKKINPGFYCFEKQELVNVLSKIDNKNSQNEYYLTDAIEILNRSGKKVVKVTVEDNFEVMGINSRYELFVAEQELKLRINKEHLSKGVQIIDIYSTYIHPDAQIGKDTVIYPGTFILGKTSIGEDCVIGPQSYIVDSKIGNNCHILFSVIENSEIKDNVKIGPYAHLRPNSLLEEGVKIGNFVEIKNSKLGKNTKSAHLTYIGDADIGENVNLGCGTIFVNYDGYKKHRTVVENNAFIGCNSNLIAPVKIGENAYVAAGSTITEDVPANALAIARERQTNKEGWVLRRKQMYENR
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 52009 Sequence Length: 463 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
Q9PPA2
MKTSILILAAGLGTRIKSQKPKVLQELCQKSMILHILKKAFALSDDVSVVLSHQKERVEKEILEYFPKTQILEQDLQNYPGTAGALSGFEPKNERVLILCGDMPLVEQTSLEALLGNNAKLNLAVFKARDPKSYGRVVIKNDSVEKIVEFKDANTQEKEINTCNAGVYVIDSRLLKELLPLIDNNNAAKEYYLTDIVKLAKEKDVMIKAVFVDEDEFMGINDKFELSIAENFMQKKIKKYWMQQGVIFHLPQSTFIGADVEFVGECEVYENVRIEGKSKIINSIIKSSSVIENSIVENSDVGPLAHLRPNCELKNTHIGNFVECKNAKLNTVKAGHLSYLGDCEIDSGTNIGCGTITCNYDGVKKHKTIIGKNVFVGSDTQFIAPVKIEDEVIIAAGSTVSINVEKGALFINRAGHKMIKDYYYKKFQK
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 47906 Sequence Length: 429 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
A0R3C7
MTASTEAAVVVLAAGAGTRMRSDTPKVLHTLAGRGMLAHVLHTVSEIDARHLVAVLGHDRERIAPEVARLSEELGRAIDVAVQDQQLGTGHAVNCGLTALPHDFAGMVVVTSGDVPLLDTATLTGLITSHGSGDAAATVLTTTLPDPTGYGRILRTQDHEIIGIVEQADATESQRTICEVNTGVYAFDIADLRSALTRLRSDNAQHELYLTDVVEILRQDHRTVRALHVDDSALVTGVNDRVQLSDLGKVLNRRIVAAHQRAGVTIIDPGSTWIDIDVQIGQDTVVHPGTQLLGATRVGSHCVIGPDTTLTHVTVGDGASVVRTHGSESVIGAGATVGPFTYLRPGTNLGADGKLGAFVETKNCTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGENKSRTTIGSHVRTGSDTMFVAPVTVGDGAYTGAGTVLRDDVPPGALAVSAGPQRNIEGWVAKKRPGSAADKAARKALGDES
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 50295 Sequence Length: 482 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
Q1DCI1
MSVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAVEKAVRGLFPDAPLRFALQREQRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEALLAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEHKDCTPEQRAVRECNAGIYSVDADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARARVLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSVLHASTVADGTVIKPYSVLEEARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGKGSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTELGDGVFIGSDTQLVAPVKVGDGSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 49029 Sequence Length: 466 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
Q67JC8
MSDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERIREYLGDRVRYAVQSEQLGTGHAVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAHVEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKDATPEQRRIREIWTGVAVFRRAGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEARLRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTTIVSSTVAEGCVVEQSVVEESYVGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRGVKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIGSGAFIGTNVNLIAPITVGDGALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 50885 Sequence Length: 471 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
Q2JII9
MAERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQEQVRQALREYPVEFVEQAQQLGTGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVERHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEERDCTPAQRQNRRINSGVYCFHWPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQDRLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIESSEIGSGCHILYSVVSHSRIGNHVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSKTGANSVLVAPLQVGSDVTIAAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPGQDLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPDGVHLHLTVADARGQTWGGHLRPGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPVAGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Catalytic Activity: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate Sequence Mass (Da): 69354 Sequence Length: 632 Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Subcellular Location: Cytoplasm
P25462
MAQAVVPAMQCRVGVKAAAGRVWSAGRTRTGRGGASPGFKVMAVSTGSTGVVPRLEQLLNMDTTPYTDKVIAEYIWVGGSGIDIRSKSRTISKPVEDPSELPKWNYDGSSTGQAPGEDSEVILYPQAIFKDPFRGGNNVLVICDTYTPQGEPLPTNKRHRAAQIFSDPKVGEQVPWFGIEQEYTLLQKDVNWPLGWPVGGFPGPQGPYYCAVGADKSFGRDISDAHYKACLYAGINISGTNGEVMPGQWEYQVGPSVGIEAGDHIWISRYILERITEQAGVVLTLDPKPIQGDWNGAGCHTNYSTKTMREDGGFEEIKRAILNLSLRHDLHISAYGEGNERRLTGKHETASIGTFSWGVANRGCSIRVGRDTEAKGKGYLEDRRPASNMDPYIVTGLLAETTILWQPSLEAEALAAKKLALKV
Function: The light-modulated chloroplast enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration. Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 46017 Sequence Length: 423 Subcellular Location: Plastid EC: 6.3.1.2
O29313
MVRRLRGDCMEEVERAKAVLKENNVRQVLCAFADVRGYLQMFSIPAREFVDGSAFENGIGFDGSSVRGFRTIEKSDMVWMPDASSLKIIPWIDDPIQKSAIMFGNVYEAWGTEIADCDPRGYVAKRYEDMLKSEGMSAIFGPEIEFFLFEGVDFTRLSWDMWVSPNGGAGDSWGPPRIMPISSELESGYMIRPKEGYFRPPPEDTTVEYRNELVYYLEQLGIDIEYHHHEVATAGQVELDFKPKQLVDVGDAFYLYKFAAKNIAAMHGLYATFMPKPLYLDNASGMHTHQSLWKGEPFSGEAVFADPDDEYMLSQKARYYIGGLLEHAKALTALCAPTVNSYKRLVPGFEAPIYICWSPRNRSALVRVPMYVKKPSAIRVEYRGVDPSCNPYLAITAQLAAGLDGIKKKIDPGDPLLEDVYELTPAQKRELGVGELPTTLRDAIDHLASDELMQEVLGSHIFDAFMELKIDEWNQYCLYITPWEFMKYFDI
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Beta-glutamate is a much poorer substrate than alpha-glutamate. Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 55723 Sequence Length: 491 Subcellular Location: Cytoplasm EC: 6.3.1.2
P34497
MTHLNFETRMPLGTAVIDQFLGLRPHPTKIQATYVWIDGTGENLRSKTRTFDKLPKRIEDYPIWNYDGSSTGQAKGRDSDRYLRPVAAYPDPFLGGGNKLVMCDTLDHQMQPTATSHRQACAEIMHEIRDTRPWFGMEQEYLIVDRDEHPLGWPKHGFPDPQGKYYCSVGADRAFGREVVETHYRACLHAGLNIFGTNAEVTPGQWEFQIGTCEGIDMGDQLWMSRYILHRVAEQFGVCVSLDPKPKVTMGDWNGAGCHTNFSTAEMRAPGGIAAIEAAMTGLKRTHLEAMKVYDPHGGEDNLRRLTGRHETSSADKFSWGVANRGCSIRIPRQVAAERKGYLEDRRPSSNCDPYQVTAMIAQSILF
Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 41284 Sequence Length: 367 Subcellular Location: Cytoplasm EC: 6.3.1.2
Q8HZM5
MATSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKGVEELPEWNFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKIAGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEESIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
Function: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). PTM: Palmitoylated; undergoes autopalmitoylation. Location Topology: Lipid-anchor Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 42028 Sequence Length: 373 Subcellular Location: Cytoplasm EC: 6.3.1.2
P16580
MATSASSHLSKAIKHMYMKLPQGEKVQAMYIWIDGTGEHLRCKTRTLDHEPKSLEDLPEWNFDGSSTFQAEGSNSDMYLRPAAMFRDPFRKDPNKLVLCEVFKYNRQSADTNLRHTCRRIMDMVSNQHPWFGMEQEYTLLGTDGHPFGWPSNCFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGVKIGGTNAEVMPAQWEFQVGPCEGIEMGDHLWIARFILHRVCEDFGVIVSFDPKPIPGNWNGAGCHTNFSTKNMREDGGLKHIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSSIHEFSAGVANRGASIRIPRNVGHEKKGYFEDRGPSANCDPYAVTEALVRTCLLNETGDEPFEYKN
Function: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine . When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia . Also acts as glutamate decarboxylase by catalyzing the production of 4-aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner . Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 42146 Sequence Length: 373 Subcellular Location: Cytoplasm EC: 6.3.1.2
Q12613
MATEAAVVSNPNTLAKYLKLDQKGSIMAEYIWIDADGETRSKSRTLKEKEYTPEDLPMWNFDGSSTGQAPGDNSDVYLKPVAVFPDPFRGSPNILVLSECWNADGTPNKYNYRHECAKLMEAHAAHEPWFGLEQEYTLLDLSNRPFGWPANGFPAPQGPYYCGVGTGKVVQRDIVDAHYKACLYSGVKISGTNAEVMPAQWEFQVGPCVGIEMGDHLWLARFLLARIAEEFGAKVSVDPKPIPGDWNGAGLHSNFSTKEMRVEGGMKHIEAAIKKLEGRHKEHIAVYGEGNEKRLTGRHETGAIDQFSYGVANRGASIRIPREYTAKGYGYFEDRRPASNADPYRITGILMETIYGSVDN
Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 39963 Sequence Length: 360 Subcellular Location: Cytoplasm EC: 6.3.1.2
P04773
MATSASSHLNKGIKQMYMSLPQGEKVQAMYIWVDGTGEGLRCKTRTLDCEPKCVEELPEWNFDGSSTFQSESSNSDMYLSPVAMFRDPFRKEPNKLVFCEVFKYNQKPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLLGTDGHPFGWPSDGFPGPQGLYYCGVGADKAYRRDIMEAHYRACLYAGVKITGTYAEVKHAQWEFQIGPCEGIRMGDHLWVARFILHRVCKDFGVIATFDSKPIPGNWNGAGCHTNFSTKTMREENGLKHIKEAIEKLSKRHRYHIRAYDPKGGLDNARRLTGFHKTSNINDFSAGVADRSASIRIPRTVGQEKKGYFEARCPSANCDPFAVTEAIVRTCLLNETGDQPFQYKN
Function: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). PTM: Palmitoylated; undergoes autopalmitoylation. Location Topology: Lipid-anchor Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 42320 Sequence Length: 373 Subcellular Location: Cytoplasm EC: 6.3.1.2
P11600
KAQEPWFGIEQEYTLLNSVTKWPLGWPKGGYPAGQGPYYCSVGAGRSIGRDIPEVHYRCCLHAGIQISGVNGEVLPSQWEYQVGPVEGIAMGDQMWMSRYLMYRVAELFNVEVTFDPKPIPGDWNGSGGHVNFSNRQPESPPAGKQSRSSAKKLGKRHRWHIAAYGEGNERRLTGKHETSSMNDFSWGVANRGCSIRVGRMVPVEKCGYYEDRRPSSNLDPYVVTRLLVETTLL
Catalytic Activity: ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate Sequence Mass (Da): 26224 Sequence Length: 234 Subcellular Location: Cytoplasm EC: 6.3.1.2
Q2N784
MTDPKVPRQRRIIDRRKLAAAVEALAEQQGEKARPAVLKVLREALEKGRDELSQRLLDRPSAGHQITAGHAFLVDQLVRVIFDHVTTHLYPVANRSSSERIAVLAVGGYGRAEMAPQSDVDIAFLHPSRRTPWCEQVTEAMLYFLWDLGFKVGQSSRTPEDMVRMAREDLTIRTALLEARFVWGDRELYDEARKRFWSEVVNGTERQFVAEKLAERDARHERMGGTRYVVEPNVKEGKGGLRDLQTLYWIGKYIHRARGAAELVDAGLLTETEYHGFRRAEGFLLAVRCHLHEITGRPEDRLTFDFQKQIAERMRFAERREKSAVERFMQYYFLQVKRVGSLTGVFLAQMDQQFARKRARTGLLAGFNAKSRMLKGYTVFGGKIAAPGDNWFRDDPVRLIEIFQLAEANGLEIDPRSMRQADRDSVLIKDQVRNDPRANAIFLDLLCGRNDPETALRWMNEAGVFGKFVPDFGRVNAQMQFNMYHHYTVDEHTIRAIGFLSKIEKGELAKEHPRSTREIHKVKSRRVAFVAALLHDIAKGRGGDHSILGAEVAEELCPRFGLDEDETDLVAWLVLQHLLMSSTAQKRDLTDPKTIEDFVAEVQSLERLRHLAILTSVDIRAVGPGTWNSWKGQLLGELYDAAHERLRLGHMKHHRSERVAAKKEAVREALGGKAALLEKHGRLLPDSYWIAEPENVISRNIVQYDVAREISEDLSIHCEFDEERGATLVTVIAADHPGLFYRIAGGIHLAGGNIIDARIHTTRNGWAIDNYLVQDPVGQPFAEERQLARIEQAIADAIANRGELVPKLAKRPLKQTRAGAFDVRPRVLFDNDASGRFTVIEVNARDRAALLNRLGRALFENQVIVQSAHITAYGERAADTFYVTDLTGAKITDESRMDTIRQALLDAASDARQAELEPA
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 104003 Sequence Length: 919 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Q5FPT6
MKETSFWGETPSLSFADDTDKPLSDRTASPPCDPASSLQTALDTAAAQGQTTRENVLSILRRHLGSGNATVRREFEKRRMSGIDAARALARQADDMVCALAELAAQKHESPGETLCLCATGGYGAGLLAPFSDIDILFLIPGDPTPAMTARIEFILYALWDLGLRVGHATRSIAECVRDADSDLTIRTALLDLRFLHGERGLARDLRCALGADLQNDRLCEFVMGKIAEREQRHRRFGDNPYMVEPNIKEGRGGLRDLQTLNWMGRAALGCAVSTPDRSGQPAEAPQTPSFASFGLLTDRESLRARRSWDFLWTVRLHLHYITGRAEERLTFDVQPVIGGRMGYATHGRQRGVERFMRHYFLTARDVMRLTSVLQPVVLMHLQDQTTGEPPKVVPGPEEFQTIAGRICPIEPVTFAAQPREMFRLLDCGRRHDLPLHPIAMQQIIRNERHAVTLRDDPETAKIFLDLLCEPSADETKAVPFWLPILNETGLLGRLLPDWSRVVGQMQFDSYHIYTVDEHIVEAVRMMGQIEAGRMADEIPLAYTLASDLRSRRALYVAVLLHDIGKGRGGDHSEIGADLALTICPQLGLDPEETDTVSWLVLHHLLLSQTAFTRDIDDPRTILDLADTIQSPERLRLLLLLTIADMRAVSPKVWNAWKATLLRELFSRVAEVLEGGLAATERDSRVNHARELARDGLTGILPESSIDRFLDLGYPSYWLGFDTDTQMRHARMVHDSDRYRSPVTVEAYPIPERGVTELTVLCADHPGLFSQIAGALAVSGASIVDARIHTLSDGMALDTFWVQDGEGCSFEEPHQLGRLNHLVEQALSGRLDIRKGIEDASHHSTSRRMRAIHVPPRVVIDNTASDRHTVIEVNGRDRPGLLHDVTSALSSASLQISSAHITTYGMRAVDVFYVRDLLGMKITDPVRLARLRETLLASLTSAPVTTPAS
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 105398 Sequence Length: 949 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
P43919
MLFSPTLSSLLTPSAVKIERENLKQFELENFSCYSIFELIENRCDFYDALLIQLWQEIGLSEQQGISLIAVGGYGRREMFPLSDLDFLILVEQTPSHEIEEKITQFIQFLWDCGFEVGNSVRTLEQCELEGKQDITIATNLLEARFLTGNRPHFDVLNELVKRADFWSKEDFFNAKVQEQIERYQRYHNTAYNLEPDIKFSPGGLRDLHLLYWVALRHSGALTLEAILQSGFIYPQEYQQLQESRAFLFKVRFALHLILKRYDNRLLFDRQIKVSELLGFRGEGNPAVEKMMKCFFQALHRISLISNLLIQHYRENVLSSNQDTVIDQLDDDFQLINQSLCLRNSFVFQEKPARILDLFFYLTQYEHVNIHSDTLRQLQISLEQLSQKLCEIPAAREKFLRLFNQSNAIKRAFMPMHQYGVLTAYLPQWQAIEGLMQFDLFHIYTVDEHTLRVMLKLESFLPKGSAQEHPIAHRIFSQLSDRTLLYIAALFHDIAKGRGGDHAELGAEDVADFAQLHGLDRREIDTLAWLVQSHLLMSITAQRRDIHDPEVVMNFAEAMQNQVRLDYLTCLTVADICATNGNLWNSWKRSLFASLYEFTEQQFSQGMKELLDYSEKSAENRKLAQQILTQDYSDITSISIEKLWTRCPEDYFVRNTPKQIAWHTSLLVDFVEALLVKISNRFSLGGTEVFIYCQDQPHLFNKVVSTIGAKKFSIHDAQIITTQDGYVFDSFIITELNGELVEFDRRRELEQALTVALQSEKLPALSIVPNRQLQHFTVQTDVRFLQENKKEHTEMELVALDKAGLLAQVSQIFTELNLNLLNAKITTVGEKAEDFFILTNQFGQALAREERERLNSVIIQQIR
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 100173 Sequence Length: 863 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Q31G41
MATTTDKQVSPTSPSFVYNLDHEDRNTSLKSGRAVLTDFNEQQFVKFDKGCSIETLLKERTSFIDQLLKKIWEHFFSKDECEQLTLVAVGGYGRGELQPYSDIDLLILGENFIELQPKIVEFITYLWDIGFEVGHAVRNLEDCIEAGREDVTTATNLLEARWLAGNYEQFLSLQNLFNLKSFWPSHEFFQAKLEEQEKRHKRYNDTLYQLEPNIKESPGGLRDIQTILWVAKRHFGASSLQELMQHNFISLQEYKEIQAAYLYLNRIRFALHRLKKRHEDRLLFDHQQQLAELLNHDDRPEHNDSIKAVEAFMKPYYQNAHIVARLNEILLQHFKEEIYHFAEDKIEPINPRFRIINNYLDVVKENLFAKNPTALLEIFIIIENYQHLIQGIRSRTIRLIRNHLHLIDDQFRSDPINKALFIEIFRQPKGVNAAVKRMYAYGILGAYLPSFKKITGLMQFNIFHAYTVDEHTILVIRNLRRFFIKQHAYEFPTAHQIATQLCKPEILLLAGLFHDIAKGRNGAHEKLGAVDAKAFSQKHNLNKNDTDLLSWLVLRHLDFSYVAQKKDLSDPEIIQQFAEKVGTQQRLDYLYLLTLADVRSTSDEVWNDWKNQLFLQLYHNTTQALDSSSSQPRDRVKQAIFNKEKASELLKKRGLIPMHFQGFWQAFEQTDFFNRQSAAEIARITRVLFEEDHEAINIHLQPTTSRGATELIIYMHDRDYLFAQFTQIIDKLDLNIVEAKIYSGEDDMTLVIIYLLNRESTSITDPMILTEIEETLKHQLFLKDDTMPPTQPEPRRIRVFEMPTHIQFQEINEELTELSISTKDIPGLLAKIGQAFKSCKIRVHDAKINTVGEKAEDTFMISSTTNESIHTRHSQEELKQALLNNIEQ
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 103724 Sequence Length: 888 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Q5QXT0
MANVQEDKDFHGRWPDRTLQPCLKDYKALLESYQNWSAARFVTADIDELVHHRATFFDQLISQLWQQFQLEDEPASILAVGGYGRETLHPGSDIDLLILVGPENAEAEAKLSEKLGQFVTFLWDLHLDIGHSVRTIEDCFAQSENDITIATNLIESRYLSGAESLYNEFHQQLLNDFPWSSRDFYQAKLDEQKQRHQQYHSTSYNLEPNIKSSPGGLRDIQTVGWIAKRHFRTHSDENLVEYGYMTADEFVELRDCMNWLWRIRFALHLEAGKREDRLLFDFQPGVAVRLGYGNDGKASVETMMKDYFKVVLRVSELNQMLLQFFHQAILGTQDLQHAEHISDDFAVANKLLTARHDNVFDNHCNIIRAFVCIAEHPQIQGIHSNTIRLLRNARAQLSEPLSHDPECRDLFNQLIQHPRGCGLSFALMHHHSVLASYLSQWQQIVGQMQFDLFHAYTVDEHTFRLVRNLYRFSDEDYQDQFPLCEKLVAQMDRRYCLYLAGIFHDIAKGRGGDHSELGEMDARNFCHQHGYSEEDAELVAWLVRHHLTMSVTAQKRDIHDPEVIQDFANQVSTPERLDYLYCLTVADIRATNQSLWNNWKATLLEELYNATSYLLQQDSNKPTLDIRQKINENKASAMALLLSAGFEKAEILALWGRFTADYFFRHTAEQISWHSQHILNLPSEQLPLILIGDENNYGTTELFIYHHEEGHLFASVAGVLDSQQLNILDAQILATRDGFVMDTFVVLQRDGKPLTEPHRIEEVKQQLLDVLHKRIPVPSTKRPLSRRMKNFSVATEVTFIPSKHHGRTTFELVTLDRPGLIAKLAAILQQQNVILLAAKITTIGEQAEDLFIVTTEQQTALSDKQKKTLKAKIIKDLEF
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 101332 Sequence Length: 879 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
P41393
MSNSLSNTVPPDLSAQPENPGEWPKSDFNCATIKALIDAFQRWLGEAFDSGIAAERLIEARTEFIDQLLQRLWVEYGFGSINDIALVAVGGYGRGELHPLSDIDLLILSRKKLPDEQAQKVGERLALLWDIKLEVGHSVRTLEECLLEGLSDLSVATNLIESRLLIGDVALFLELQKHIFSDGFWPSEKFFAAKVEEQNDRHQRYHGTSYNLEPDVKSSPGGLRDIHTLQWIARRHFGATSLDEMVGFGFLTEAERNELNECLHQLWRIRFALHLELNRYDNRLLFDRQFSVARRLRYEGESNQPIEHMMKDFFRVTRRVSELNQMLIQLFEEAILALTEDEKPRPIDDDFQLRGTLIDLRDDTLFIREPQAILRMFYTMVRNSSITGIYSTTVRHLRHARRHLTQPLCYIPEARTLFLSMLRHQGGLSRGLLPMHRHSVLWAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVLLKLESFAKEETRSRHPLWLELWPRLTHPELILIAALFHDIAKGAGGDHSILGAQDVLKFAELHGLNCAQTQLVAWLVRHQLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLHYLVCLTVADICATNENLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMENINEQALHQIWNRCRANYFVRHTPNQLAWHARNLLKHDLSKPMILLSSHATRGGTEIFIWSPDRPYLFAAVSAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRTQMIRVGLEQTLSQRSWQPPAPRRQAAKLRHFSVPTEVNFLPTHTDRKSFLELIALDQPGLLARVGQVFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVQQRLTEALNPNDKG
Function: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism (Probable). Catalytic Activity: [protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate Sequence Mass (Da): 102344 Sequence Length: 887 Domain: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.