ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q5NY30
MPIDPARLAFTDDGTPCSAAFGDVYHARGGGLEQARFVFIAGNGLPARWQGREHFAILETGFGFGLNFLATWDAWRADPKRCERLHFVSVERHPFTREDLATLHARWPELAPLAAELADHWPTLTPGMHRLHLNRGRVVLTLLFGDARELLPRLECGADAFFLDGFSPACNPELWSAALLAELGRLAASGATLATWSVSGDVRRALAAAGFDCEKAPGFDGKRQMCRGRHRDVGTGPAPAAAAARHALVIGAGLAGSSTAERLAARGWHVDVIDAADGPGEGASGNLTGVLRPLPSLDDNRLARITRAGALYGLHHLRQLTEAGLPVRWDACGVLHLARDPVHEDKQRRVVEAHRPPSDYLRFVERDEASTLAGWPLPVGGWWFPQGAWVSPPSLCAANLMTHPDLIRCHFGRAMQRLEASADGWTAFDADGKAIASAPVAVLANGVGIRAVPQAAALPVRSARGQVTHFPAAAGSPPNVVVCRLGYVAPALDGVRSAGATFSVDDDEPALRDADQRENLAKLEFILPGYAAAVDTAALAGRVGFRPASPDRLPMVGEVPAVLRADRATPLAQIPRHPGLYAVAGFGARGLVWASLAAELLASHIAGEPLPLERELVDALDPARYLLRPARGMTREG
Function: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. Catalytic Activity: 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 67972 Sequence Length: 637 Subcellular Location: Cytoplasm
Q2KVJ9
MSSAYQPLTPALTEVNEAGHLASRQYGDVYNSPADAYGQAVDVFLHGNDLPQRWRGRRHFTVCETGFGLGTNFLALWRAWREDPGRCGRLHMLSIEGHPLTREAYEAVLDTQVPEPLRAGARELLAQWPKLLPGLHRLEFEHGAVTLTLALGDIGQVAPRLSACVDAFFLDGFAPSKNPAMWDTYVLRRLLRLGAADATLATWTSAGFVRRGLQEAGFDIQRLTGARGKRHITVGRRSAWAGKHAPRRTDAPDAPVLVVGAGLAGAGMAQALALRGLSVRVIAESAQPHGGHLAAALTPLVARDDNARARLARAGSQRAWHRWQGLDAVRKVGALQLERDAGRSAALADTLAALHFPRDWVRWVESDEAEQLAGLPVARGGLYFADGLLVRPQPLIDALLAWPGIERVRGRVSRLVQCSAGQWQALDALGQVLGEARQVVLANAAGTPLVLEASGLLGPLPRVAQMHALAGEVSHVPAAALGGGPHCMIGGEGYVLPAVDGWCVVGSTYAPGVAQSEVSLAGQQRNLEKAAGLLGAPLDAVAGPLPGWAGWRAVMPGRLPVLGELPGVSGVWLASAYGSRGLSWSALAGDVIAARLCGEPLPLETDLLASVGPR
Function: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. Catalytic Activity: 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 65006 Sequence Length: 614 Subcellular Location: Cytoplasm
A9I518
MSSYSPLVPPAAGFDADGRFRSVAYGDVYHSLSGALGQAEHVFLRGNGLPQRWRGRQAFTVCETGFGLGLNFLALWDAWRNDPARPRCLHMVSIEAHPFARDALRDWLRQLAPDILQGLAGQLADQWPACLPGLHRLEFEGGAVTLTLAFGAASALAPHLRARVDAYFLDGFAPDRNPELWQPALMRDLARMAAPDATLATWACAGSVRQALRDAGFRVRKQPGYGGKWHMTVGVRESAQPEAPADAWALARAADGEGQDEVVVVGGGLAGAGIAQALALRGRPVCVIDAAGPASAHAGHVAAALTPVIARDDNPRARLSRAGSQRALARWAGLRPGAAPRRCGTLQLERDAGRSAALAETLQQLQFPADWVRAVDRDEAAGLAGVPLARGGVFFADGLLVQPAALIPALLGMPGVRRVAGCAAVLRRVAHGWQVLDDAGQLLGQGATVVLANAFGAQALLRDSGLLDPLPRVAQMHALAGEITLLPGQGLGGGPRCIVGGEGYLLPPVDGWCVAGSTYEHGAATARVGPAGQQTNLGKAAGLLGGLPAAWAALAPGQLPGWAGWRAVLPGRLPAVGPLGHAPGVWLAAGYASRGLSWSALAGDLIAACLHGEPLPLPADLLAAVAPR
Function: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. Catalytic Activity: 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 65133 Sequence Length: 628 Subcellular Location: Cytoplasm
P25811
MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSSVESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLALREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALVRRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKILREGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDTAGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVILNKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYVSNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQLFSQFCLGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 50974 Sequence Length: 459 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q89Z26
MNQDTICAIATAQGGAIGSIRVSGPEAISITSRIFQPAKAGKLLSEQKPYTLTFGRIYNGEEVIDEVLVSLFRAPHSYTGEDSTEITCHGSSYILQQVMQLLIKNGCRMAQPGEYTQRAFLNGKMDLSQAEAVADLIASSSAATHRLAMSQMRGGFSKELTDLRSKLLNFTSMIELELDFSEEDVEFADRSALRKLADEIEQVISRLVHSFNVGNAIKNGVPVAIIGETNAGKSTLLNVLLNEDKAIVSDIHGTTRDVIEDTINIGGITFRFIDTAGIRETNDTIESLGIERTFQKLDQAEIVLWMVDSSDASSQIKQLSEKIIPRCEEKQLIVVFNKADLIEEMQKEELSALLKNFPKEYTKSIFISAKERRQTDELQKMLINAAHLPTVTQNDIIVTNVRHYEALSKALDAIHRVQDGLDSHISGDFLSQDIRECIFFISDIAGEVTNDMVLQNIFQHFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 51612 Sequence Length: 465 Subcellular Location: Cytoplasm EC: 3.6.-.-
A1UQU6
MDTIFAVSSGLLPSGVAVIRVSGPRVVDIVKTLCGCLPKARFMHHGDLIARDGSFLDSALTVFFPRPHSFTGEDCAEFHLHGGKAVVNRFLDELSTFTGCRLAEAGEFSRRAFIEGKIDLVQAEGLADLIEAETESQRRLAVMGANGHLTELYRHWRNKLMTARALIEAELDFSDEADVSNFSSDKVWQNMQELSDSLCEHIAEGERANILRDGIKVVIVGVPNSGKSSIINRLAGRPVAIVTEEEGTTRDALEVRLILGGLPVLVMDTAGFRETESKIEQLGIDIAKQHVLDADLVILVDDMKNPQKISLPNTSAEIWRVGNKLDICEGDKTRWPIQFSALNGLNFDYFLKEIESFCLHRIAEIGNIFPARKRQIQLLKEAVKEIDSSINYTFLDLSLRAEHLRRASDALGRITGDIDVEDLLDIIFSQFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 48261 Sequence Length: 435 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q6MGL5
MGPMIRGDRDKDTICAISTPHGVGGISVIRVSGPQTLNIVSKICQFLPAHPESHKVYFGNLKNSQTGDEIDEVLATYFKEGRSFTGEEVIEISCHGSPLICQTILNQLVNLGARPADRGEFTFRAFMNGKLDLVQAESVLSLIESQSQQAAKLALRQLKGTLSHKLEEIEDDMTWILAHAEASIDFSTEGIEVIEENVIQVRLKKIEAGLKELVATFKVGRLLKDGFRIVLTGLPNVGKSSLLNLFLEDERAIVTDIPGTTRDVIHGDTTFEGVKFTFVDTAGLRDEATDLVERIGIQKSYEAQNESDVVFFVYDIEKGLGAEELQILESLDPAKTYILANKTDKIGGSKPLETVEKTLKNSKFFQKLADPAAFFTRRVFFVSALDKKVRSEVLKDLVKEFADLQVENTVLISNARHFENLTRALENTQRSQSVVAQGLGAEFLALEFKEALIAIHETLGKRFDDQIMDRVFKEFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 53216 Sequence Length: 479 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q7VQV3
MKNNEIDTIAAISTPIGRGGIGIIRVSGKLVPEVAMKLFNKIPKPRTAEYLTCIDHNGSIMEKVITLFFPEPHSFTGENILEIHGHGGQMILDLLLDRILNISSRIRLANPGEFTERAFLNEKIDLIQAESIADIINATSYQAAKSACNSLQGHFSNQIRIILNKITNFRTYIESTLDFSDQEISDISYQHIYNTLQNIIDNTNQICKLTHSGVLLRDGIKVVIAGKPNAGKSSLFNSLINKDRAIISNISGTTRDILHEYIQLNGIAFHIIDTAGFKKNSTNEIELIGMQKSKYELSKADHILWVIDSTDYSHNNSYNNIINSLKKELSSNNIEAVFITIIRNKSDLSFEHNGIDTTNKYACITLSALLNHGIDLLKKHLYDSAMLQIHKNSNFSSVEENQGNFIARKRHLKILQKVFQYLLSAKTQLQYNMTVNDCFAEDLKKAHEELAQIFGKLTPDDLLEEIFRAFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 53355 Sequence Length: 474 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q494C0
MNYTIDTVVAISTPPGRGGIGIIRISGKSVPEIAPKLLGKIPNPRKAEYLPFLDTDGSILERVIALFFPEPNSFTGENILEIHGHGGQIILDILLERILKTSSDIRIAHPGEFTKRAFLNNKIDLVQAEAIADIIDATSYQAAKSASNSLQGIFSRKIYIILEQLTNLRMYAESSIDFSEDEISIIPYEDIKKKLRNIISDVQKMYKSTYHGVLLREGIKIVIAGKPNAGKSSLFNALVGIDRAIISTISGTTRDTLHEYIQLNGIAFHITDTAGLQKKSDNEIEQIGMKRTWEELSNADHILWVIDPNDVTNKENDITLKHVEKVLFCKNKKTPITIIHNKSDLTKNQIGISIINNYTIITLSALFNDGTDLLQEYLSNNIKSKIQQDCKSNLSENQGNFIARRRHLNALEKSSKYLFSAQTQLLSTMSINELFAEDLGLAHKELSKIFGKFTPDDLLKRIFSTFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 52560 Sequence Length: 470 Subcellular Location: Cytoplasm EC: 3.6.-.-
P53364
MSKFFERDDDIVALATPFLSSALCVIRSSGASSISKFSKIFSNHSALNSASGNTIHYGYILDSENGCKVDEVVVCLYRAPKSFTGQDAIEVMAHGSVIGIKKIIDLFLKSGFRMAEPGEFTLRAFLAKKIDLTKAEAIHEIIFAKTNKTYSLAVNKLSGALFVKIDAIKKSILNFLSAVSVYLDYEVDDHEISIPFDLILSSKAELKKLINSYKVYEKIDNGVALVLAGSVNAGKSSLFNLFLKKDRSIVSSYPGTTRDYIEASFELDGILFNLFDTAGLRDADNFVERLGIEKSNSLIKEASLVIYVIDVSSNLTKDDFLFIDSNKSNSKILFVLNKIDLKINKSTEEFVRSKVLNSSNLIMISTKNLEGIDILYDKIRALISYERVEIGLDDIIISSNRQMQLLEKAYALILDLLSKIDRQVSYDMLAFDAYEIINCLGEITGEVSSEDVLDNMFKNFCLGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 51606 Sequence Length: 464 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q7VJY2
MKNTLSSMILDDSTIVAIATPIGVGAISIVRLSGEKAYHIALALTHKESLKPRYAHLCHIYDAQQMPIDEALVLYFPKPYSYTTQDVCEVQCHGGIVSARAIVQLCLKLGARMAQAGEFAKRAFLGGRLDLAQVQAVAGLIQSQSLEANKILMRQLKGDLGTFVNRTRENLLEILAFSEVHIDYSEEVEESYIRDIQQKLAYVENELSHIYHISLTRQSIIEGYTLSIIGKPNVGKSSLLNALLRYERAIVSEIEGTTRDTIEEMLTIKGSLLRIVDTAGIRESDDKIEQIGILKTKEALMRSNIIVAIFDGSRPFDAEDKAIMEILKTQCQNKYILVIINKSDLPLQCEEELLHNLLRLHNKALLCMPLHLSTKYEGVQKVLECLEEVVSTHNGDESMILTSSYQLDCIKKALECIVKAHNVLDIGQLELFSYQIQDCIESICKITHPYENAELLDRLFATFCLGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 52356 Sequence Length: 467 Subcellular Location: Cytoplasm EC: 3.6.-.-
B0TAB6
MVGDTIAAVATPPGEGGIGIVRVSGPGARDVLKAVFRPRYGRGVDDWASHTLHLGTIIHPDDHRVIDEALVAWMVAPRTFTTEDVVEFHCHGGSVPVRETLGAVLRAGARLAEPGEFTRRAFLGGRLDLAQAEAIIEVIRAKTRDGLGAAVSQLEGQLSRRIRKVRDDLLALLAHLEAMIDFPEEDLPDIGSERICTDLMQIQRQIGDMLERSRTGRVLREGWRTVIVGRPNVGKSSLMNALLDEQRAIVTEIPGTTRDAIEEYIDLGGIPLRIVDTAGIRETEDVVERIGVEKTREYLEKADLALVVLDGSDSLTAEDETLLLSLAGRPAVVLVNKSDLAVRRLDEKRLRSLVGEMPIISVSAKEGWGLKELTELIRRMVYGDDGLGYAPDGGRLALVTQARHREALERSYAHLRQALDAVAHGASPDFLTIDLKAAWEALGEITGDTVGEDILDKIFSSFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 50851 Sequence Length: 466 Subcellular Location: Cytoplasm EC: 3.6.-.-
O25991
MKNTSSSTTLTMNDTIAAIATPLGKGAISIIKISGHNALNILKQLTQKQDFTPRYAYVHDIFSNGVLLDKALVIYFKAPYSFTGEDVCEIQCHGSPLLAQNILQACLNLGARLAKAGEFSKKAFLNHKMDLSEIEASVQLILCEDESVLNALARQLKGELKIFIEEARGNLLKLLASSEVLIDYSEEDIPSDFLDGVSLNLEKQIASFKDLLDFSNAQKQRNKGHALSIVGKPNAGKSSLLNAMLLEERALVSDIKGTTRDTIEEVIELKGHKVRLIDTAGIRESADKIERLGIEKSLKSLENCDIILGVFDLSKPLEKEDFNLIDTLNRAKKPCIVVLNKNDLAPKLELEILKSYLKIPYTLLETNTLNSKACLKDLSQKISAFFPKLDTQNKLLLTSLAQKIALENAITELQNAKNHLETLELFSYHILSAIENLNLLTRPYETSQMLDSMFSEFCLGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 51170 Sequence Length: 461 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q28VZ6
MQTIFAQATARGKAGVAIIRISGPDAFEVGRCLLGSLPDAGRFALRDVRTPLGELLDRGLVLVFKAPASFTGEDTVELQLHGSVAVVRAVEGAIRSTGLARLADAGEFTQRALLNDMLDLTQVEGLGRLIDSETEAQRKVAQASFEGGLSDKAERWRHLMIRAAALLEASIDFVDEDVPVDVVPEVQSILMGLDTDLAKEVTGAVVAERLHDGFEVAILGAPNAGKSTLLNVLADREIAITSDVPGTTRDVIEARLDVSGLPVTFLDTAGIRDTVDVIEKIGVQRAIDRALAADVRILLEIDDWILPDVLSDTIDFRYRAKADLSDGEGISGRTGVGIDRLLTDIEGVLSEKMSAVRSAVTDRQRGGIEAARVSLDAGVTVLSGTAELELAAEHIRHAQRSLDSVIGRVDVENLLGEIFSRFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 45517 Sequence Length: 426 Subcellular Location: Cytoplasm EC: 3.6.-.-
A8Z5X0
MLKNDDTIVAIATPSGYGAIAVIRISGNNSIKIIKKIFCSFSKNQIETNYIHLGYIKYKKQIIDKVLIFLFKKPKSYTGEDIVEISCHGSIYIQNKLLSIIIDQGARLANPGEFTLRAFLNGKIDLCQAESILDIVNSETFFSHKFAINQMRGNISLLIRKLSKEIINLLSLIEFELDFSEENCNFINYLEFKKMLYNIIKKLKTLIRSFKIGNALKNGISVSIIGCPNVGKSTLFNKLLKYERSIVSNIAGTTRNYIEDSLIINGIKFRFIDTAGINNNTKDYIEKLGIKKTYSKINKSDLILYVFDDLNEKFILKKVKSLQEKYPKKKIFIIINKYDLIKKKIKEFNYKKIFKISAKYGYGVNNLLSEITFFSKKITSLKENTIVITQTRHYESFKKAIFYLYKVKKNLYSISPEFLSIDIRTALDYLGKVTGEVTNEDILSNIFSKFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 52174 Sequence Length: 454 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q1IHC2
MNLDDTIVAIATPPGRGGIGVVRLAGPEARTVALLMLRLANGKAELEAQRAHFAELVDPESGERLDEVVVAYFAKPHSYTTDDIVEISCHGSPVLLARVVELALAKGVRMADPGEFTMRAFLNGRIDLTQAEAVRDLIESQTLYQARVAAQQLGGSVSRRLQPTKQKLVNLIAVLEAGIDFADDDVSVLPAKEAIARIAEVHEPLAKLKEGFAFGKVVHEGLTLAIVGRPNVGKSSLFNRLVERDRAIVTAIPGTTRDLVTETVSLGGIPVHLVDTAGIRESHDEAESIGIQKSREAMADADLVLVVVDAHAETGHELDHQLISAAAERSAILVENKIDLGRHSVANGKSIPVVRTSAVSGEGIAELREQILRMVSGESGREESGFLTNIRQHQLVTDSLAALEAATNALEVRVPHEMVLMDLYNALRPLDDITGATTADDILNLIFSTFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 48692 Sequence Length: 454 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q9ZCI1
METIFAQSSAFGKAGVAVFRISGPKSLEVLQLLTGRKDFKPRLMYYQQIIVPETNELIDNAMVVYFKLPNSFTGEDVVEIHTHGSKAISIMLINTLLNIADIRLAEAGEFTKRAFLNNKFDLTAAEGIADLINAETIMQHRQAVRQANGGLKELYNKWRNQLLKIISLLEAYIDFPDEDIPESILNDVNNTHKNIVNEISNYLNDNRRGELLNNGLKLAIIGPPNTGKSSLLNFLMQRNIAIVSNIAGTTRDIIEGHLDIGGYPIILQDTAGIRTESTDIIEQEGIKRAINSAKTANIKIVMFDAEKLDSSINNDITGLIDENTIVIINKIDLIEPNKTFAIENRYKCLRVSVKNNIALSNILKNIENIAENLAGVTETPYITNQRHRHYLKQALSHLIDFNLDNDLVLATEDIRMTVRCIGLITGVINVEEILNEIFKNFCIGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 49813 Sequence Length: 445 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q16CZ5
MDTVFALGSAQGRAGVSVIRLSGPAAWAVAETICGSLPDPRKSAVRVLRAQDGSVIDQALVLAFKAPHSFTGEDVVEFHVHGSIAVVRTVLDALSDQDVARLAEAGEFTRRALENGKLDLSQVEGLADLIDAETEAQRRQAVRVLTGALGEKVEVWRSKLIRAAALIEATIDFADEDVPVDVTPEVTSLLEDVSSDVRTEVAGTHVAERIRSGFEIALVGAPNAGKSTLLNKLAGRDAAITSEIAGTTRDVIEVRMDLGGLPVTFLDTAGLRQSADEIETIGIERAIKRAQEADLRVFLSGPDERLLIEPLEDDIRLTPKVDLAPGSQTGISGKTGQGIPELLEKIRSVFSERVSAVGLATHERHRLAMQRALEDLDNSFEALLRGPEFYDITAQELRSAIRALETLVGRIDAENLLDEIFSSFCLGK
Cofactor: Binds 1 potassium ion per subunit. Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Sequence Mass (Da): 46025 Sequence Length: 428 Subcellular Location: Cytoplasm EC: 3.6.-.-
Q8CPM6
MGVILLNSNNNNHEQQRSLDEINNTINFNHNDSASQKFLAFLGPGLLVAVGYMDPGNWITSMQGGAQYGYTLLFIILISSLSAMLLQSMTVRLGIATGMDLAQMTRHFLNKPVAIMFWIIAELAIIATDIAEVIGSAIALDLIFGIPLIVGALITVFDVFLLLFIMKFGFRKIEAIVGTLIFTVLAIFVFEVYISSPHIIDMLNGFVPHKEIITNQGILYIALGIIGATIMPHNLYLHSSIVQSRKYDRHSIHEKAQAIKYATIDSNIQLSIAFVVNCLLLTLGAALFFGTKTEDLGGFYDLYLALKTEPALGATLGGIMSTLFAVALLASGQNSTITGTLAGQIVMEGFLKLSIPNWLRRLITRSLAVIPVIICLIVFKGNTEKIEQLLVFSQVFLSIALPFSLIPLQLATSNQNLMGPFKNKTWINIISWLLIIVLSGLNVYLIIQTFQEL
Function: H(+)-stimulated, divalent metal cation uptake system. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49783 Sequence Length: 453 Subcellular Location: Cell membrane
Q4L5B9
MGVIDNKEQRSLDEINSTIEFNDSQRTSQKFLAFLGPGLLVAVGYMDPGNWITSMQGGAQFGYTLLFVILISSLSAMLLQSMTVRLGIATDKDLAQMTRHYLNKPTAIIFWVIAELAIIATDIAEVIGSAIALDLLFNIPLIIGALITVFDVFLLLFIMKFGFRKIEAIVGTLIFTVLMIFVFEVYISSPNLIEILNGFVPHYQIIANHSILYIALGIIGATIMPHNLYLHSSIVQSRKYNRHSFTEKAQAIKFATIDSNIQLSIAFIVNCLLLVLGAALFYGVNSNNIGGFYDLYQALRTQPVLGVVMGSIMSTLFAIALLASGQNSTITGTLAGQIVMEGFLKLSIPNWMRRLVTRSLAVIPVLLCLVIFRGNESKMEQLLVFSQVFLSIALPFSLIPLQLATSNEKLMGPFKNKKWVNICAWGLIIILSFLNIYLIIETFKEL
Function: H(+)-stimulated, divalent metal cation uptake system. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49423 Sequence Length: 446 Subcellular Location: Cell membrane
P54512
MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIEHHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ
Function: Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems . In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes . The manganese concentration required for activation of efflux is higher than that for repression of uptake . Sequence Mass (Da): 16759 Sequence Length: 142 Domain: Contains an N-terminal DNA-binding domain and a C-terminal dimerization domain . Contains two metal binding sites per subunit, site A (corresponding to metal ion 2) and site C (corresponding to metal ion 1), which both contribute to the metal selectivity of MntR. A large metal cation is needed at the A site to correctly orient and position the C site ligands. Smaller, non-cognate metal cations bind at the A site, but disrupt the C site, blocking the full activation of MntR. Binding at the C site also favors Mn(2+) and Cd(2+) over other metals . Subcellular Location: Cytoplasm
Q8X7U4
MSRRAGTPTAKKVTQLVNEEEHVEGFRQVREAHRRELIDDYVELISDLIREVGEARQVDMAARLGVSQPTVAKMLKRLATMGLIEMIPWRGVFLTAEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSEETLDAFRLFTQKHGAK
Function: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Sequence Mass (Da): 17670 Sequence Length: 155 Domain: It contains an N-terminal DNA-binding domain and a metal-binding domain. Subcellular Location: Cytoplasm
A0R443
MTVTALGLPTVARSTGDGSAGASPAPADGPLVDTYGRAATDLRVSLTDRCNLRCTYCMPAEGLNWLPGDALLSPTELARLLRIAVARLGITSVRFTGGEPLVVRHLEEVVAAAAALEPRPEITLTTNGLGLARRAEGLKKAGLNRINVSLDSVDAAHFARITRRDRLPDVLAGLAAAKAAGLEPVKVNAVLDPVSGLDDAVELLRYCLQHGYQLRIIEQMPLDASHSWQRDNVIDADRILQTLQQHFELTPDSRPRGSAPAELWQVAEGPTHAAGTVGVIASVSHAFCSACDRTRLTADGQIRSCLFSREETDLRHLLRGGADDAEIEAAWRAAMWSKPAGHGINDPDFVQPVRPMSAIGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 38499 Sequence Length: 361 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
A0PKZ7
MTVTALGVPTVRGRSEGSAVASDAPGDGPLLDRFGRSATDLRVSLTDRCNLRCGYCMPAEGLNWLPGEQLLGPAELARLPRIAVTPLGITSVRFTGGEPLLARHLEEVVAAAAQLRPRPEISLTTNGVGLAKRAAALAEAGLDRVNVSLDTVDRAHFAAVTRRDRLTDVLDGLAGARAAGLTPVKVNAVLDPETGRQDVVELLRFCLEQGYQLRVIEQMPLDAGHQWRRNALLGSDDVLAALQPHFRLRPDPAPRGSAPAELWLVDAGPDTPAGKFGVIASVSHAFCSTCDRTRLTADGQVRSCLFSTEETDLRGLLRAGAGDEAIEAAWRGAMWAKPAGHGINNPDFLQPQRPMSAIGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 38245 Sequence Length: 360 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
A6Q5D0
MLIDGHGRKVDYLRISLTERCNFRCQYCMPEKPFSWVPKENLLNFEDLFKFVKAAIDEGITKIRLTGGEPTLRADLDKFIKMIYDYKPDIDLAMTTNGYLLKDIAQDLKKAGLKRLNISLDSLKPEVAAKIASKDVLKNVLEGIDAALEAGLKVKINMVPLKGVNEDEIVDVMEYCKDRGMQIRFIEYMENVHAHSDLVGMHGKEILDKIKQKYEIEKIGRQGSSPAFLYKLKEDGYIFGLIDPHKHDFCETCNRIRLTAEGYLIPCLYFDEAMSIKEAVQAGDIDRAVEILKTVLANKPKENRWSEDANEASNRAFYETGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 36684 Sequence Length: 322 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
Q44118
MPAARPAGAGVGLVDRYGRRATDMRLSLTDKCNLRCTYCMPAEGLEWLSKQAVMSASEIVRIVGIGVGRLGVRELRLTGGEPLVRHDLVDIIAELRRNHPELPISMTTNGVGLAKKVAPLKAAGLTRINVSLDSLHEETFTKLTRRPFLDQVLAGVDAAWAAGLGPVKLNAVLMRGINDAEAPSLLAWAVERGYELRFIEQMPLDADHGWTRRNMITAAEIRDLLSTDFVLTPDPRARDGAPAERFEVRRRVAGSGAGLGPVLGTVGIIASVTEPFCSDCRRTRITAEGRIMSCLFSREEFDLLVLLRSGASDDDLARRWQDAMWLKPKAHGMDHVGLDAPDFVQPDRSMSAIGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 38712 Sequence Length: 355 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
A1B4A2
MPAHAYLCAMDAHAPLIDPFARPITYLRVSVTDRCDFRCTYCMAEHMQFLPKRDLLTLEELDRLCSAFVGLGVRKLRVTGGEPLVRRNIMEFFRAMSRHLGAGLDELTLTTNGSQLARFATELADCGVRRVNVSLDTLDEDRFARITRWGRLPQVLQGIEAAKAAGMRVKINTVALKGFNEDELFRLVGWCADQGHDLTFIEVMPMGEMGEEERLDQYWALSDLRDRLGERFTLTPLAERTGGPARYVRLDETGQKIGFITPLTHNFCESCNRVRITCTGELFMCLGQEDRADLRAPLRAGAEDAPLRAAIRDAIARKPKGHDFDYSRRHVAGQVSRYMSHTGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 38771 Sequence Length: 344 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
Q7U3H2
MTPASALVDQRSRPLRVLRLSLTARCNLACPYCCPDLEDPPDLLSLEQQLRLIRVACRLGIHSLRLTGGEPLLSARLLPLLQAIAAARATPGDPLQGLQQVALTTNGTLLSDQRACDLRQAGLDRITVSLDGVDGAVVARMAGRPTATAGDSLARKVLGGLASARSAGFDPLAGELKLNAVIQRGVNEDQLLPLADLARDQGVELRLIEYMDVGNRNQWRLDQVLSAAEMVTRIRARWPLQAVGRPTGGTAQRWRYVDGGGHLGVIASISEPFCGDCNRLRVTADGQAFRCLFASVGTDLKPALHCEAELLRLVADLWRRRDDRYSDERQQTTGSMPHAEMAYLGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 37484 Sequence Length: 346 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
A5CYZ0
MQDTYQREINYLRISVTDRCNLRCVYCMPEEGVRSLPHGEILRLEEIETVVRAAALTGVKKIRLTGGEPLVRKGLEELVRRVSGIPGIDDIALTTNGLLLPSRAKALKEAGVKRVNVSLDTLRADRYAEITRGGNLAGAWEGIQSALDAGLHPVKLNTVIIRGFNEDEVVAMAMLTINRPLHVRFIELMPIGSSSSWAAGRYVPAAEVMDAISAKLGPLVPARQPAGGGPAKYYRLKDAAGTVGFITSMSEHFCHRCNRLRLTASGGLRPCLYDGREIDLKAPLREGAGTREIAALIMEAIALKPDRHHMLEGWRDRRQMSQIGG
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Function: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Mass (Da): 35623 Sequence Length: 325 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22
Q3ADX7
MELTHFNEEGRARMVEVTEKQETVRTAVAAGEITMRPETLELILDKKVAKGDVLAVAQVAGIMAAKKTGDLIPMCHPLNLTGVDISFTIKVPDTIEAKAKVTCVGKTGVEMEALTAVSVTLLTIYDMVKAVEKGMVIKNIRLLEKTGGKSGDYRREE
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17060 Sequence Length: 157 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
B0T229
MTRLTHIDDQGRARMVDVSDKAETVREAIAVGFVRMTPETLALAITGAGRKGDVRAVAEIAGVMAAKKTADLIPLCHPLALSKVEVSVEVAEGGLAVMARVKLKGQTGVEMEALTAVSVACLTIYDMLKAAEKGMVIETVRLVEKTGGKSGAWRAE
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16447 Sequence Length: 156 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q9AC52
MSKLTHIDDQGRARMVDVSEKPATAREAVAAGFVRMSAETLALAISGSGRKGDVRAVAELAGVMAAKKTSDLIPLCHPLALSKVEVAVEPADGGLSVTARVKTTGPTGVEMEALTAASVACLTIYDMLKAAEKGMVIEAVRLLEKTGGKSGDWKADQP
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16362 Sequence Length: 158 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
B3PDN1
MSDSLTHIDASGQASMVDVSTKAVTVREAWAQACVRMQPDTLLQVKYNQLQKGDVLAVARIAGIQAAKKCADLIPLCHPLALSKVSVDFELDETNSTVLITSYCKLSGQTGVEMEALTAASVAALTIYDMCKAVDMGMVIEQVCLLEKSGGRRGHYRRGDTVS
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17495 Sequence Length: 163 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q9ZFA6
MSGLTHFDESGRAHMVDVSEKPVTARVAVARGAVKMSAETLALVTEGRAEKGDVLGVARLAGIMGAKRTADLIPLCHPLPITKVALELTADPALPGVVVEATVKTGGQTGVEMEALTAVSVACLTIYDMVKAVEKGMEITGIRLLLKEGGKSGRFEASA
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16453 Sequence Length: 159 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q4L8D8
MSKFTHINEQGNAKMVDVSNKNITKRTAQAHSSITVNETIYQQIIDNTNKKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVQFNWQINDNTTYTLNITAIVSTTGKTGVEMEALTAASATALTVYDMTKAVDKGMIIGETYLESKSGGKSGDYRR
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17333 Sequence Length: 160 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q82H75
MTVPSRGETPGPPAQDRLTHIDEAGAARMVDVSGKDVTARTARASGRVLVSPRVVELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLSVSGVKLDLSVADDAVEILATVKTTDRTGVEMEALTAVSVAALTVIDMVKAVDKGAVITDVRVEEKTGGKSGDWSRS
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17620 Sequence Length: 170 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q9RKA8
MSTQDRPSGSGQDPQDRLTHIDEAGAARMVDVSGKDVTARTARASGRVLVAPRVVELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLSVSGVKLDLSVADDAVEITATVRTTDRTGVEMEALTAVSVAALTVVDMVKAVDKGAVITDVRVEQKTGGKSGDWTRS
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17685 Sequence Length: 170 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
B1VTN7
MTGAPSARRSELSTQNRLTHIDETGAARMVDVSQKDVTTRLARASGRVLVSPRVIELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLAVSGVEVELGVADDAVEITATVKTTDRTGVEMEALTAVSVAALTVIDMVKAVDKSAVITDVRVEAKSGGKSGDYRRTAPEGPDA
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 18442 Sequence Length: 177 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
A4VIR7
MLTHLDSLGRASMVDVTDKAVTAREAVAEARVRMLPQTLQLIQQGGHPKGDVFAVARIAGIQAAKKTHELIPLCHPLLLTSIKVELQADGEDSVLIRAVCKLAGQTGVEMEALTAASVAALTIYDMCKAVDRGMVIEGVRLLEKLGGKSGHWQVQA
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16632 Sequence Length: 156 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q4JAB2
MIDISGKDIVLREAIAEGFIKLKKDTIEKITKREIEKGDVIATAKVAGILAAKKTHELLPMCHPIPLEYINVEIEIENDGLKVVSTVRAHYRTGVEMEALTATSIALLTIWDMVKKYEKDEEGQYPLTEISKIRVVSKIKSYG
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16040 Sequence Length: 143 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q975D5
MTEAKIVDISSKDIVLREAVVEGYIKLRKETIEKIKNKEVEKGDVITVAKTAGILAAKKTPELIPMCHPIPLEFVDVEIKIEEEGLRVISTVKAHYKTGVEMEALTATSVALLTIWDMVKKYEKDENGQYPYTEIKSIRVINKIKTYDDMK
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17125 Sequence Length: 151 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q3AVP2
MQSDRNLSHLNSKGDVHMVDVGDRPSTFREAHAQGSIQMDRETFDLILRGETPKGDVLAVARIAAIQAAKRTWELIPLCHPISLSGMDVDIQPAEHLPGLRLNCRCRTTGPTGVEMEAMVAVSVGLLTLYDMLKAVDPAMTIGSIQLIHKSGGRNGVWNR
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 17466 Sequence Length: 160 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q9HKV1
MINISEKAISARTATATGRIHLRRSTIQAIREKKVKKGDVLEVSRVVGTQHAKNTFLQIPYCHNIPIEGVDVDFNVGEDYVEVSCTLTTTYKTGIEMEAISCVSGALINIWDMVKYLEKDESGNYPETRIDGIHVVEKRKTPV
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 15994 Sequence Length: 143 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
B9L0K8
MAELTHLDERGQARMVDVAEKPETHRVAVARGRVSLRPETLQLVREGRAAKGDVLAVARVAGIMAAKRTAELIPLCHPLPLTKVEVDVRTNEQDTCLEIEARVETVSRTGVEMEALTAVAVAALTVYDMLKAVDRGMTIDRIQLIEKAGGRSGTWRREDDEARHAR
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 18301 Sequence Length: 166 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
Q977Y1
MIDFDGNMINISRKDVVARKATAVGRIYLRKETITAIKNNQVKKGNVIEISRAVGTMYAKNTFLQIPYCHNIPIEGVDVDFSLGENYVEVTCSTTTSYKTGIEMEAINCVNGALLNIWDMVKYLEKDETGNYPETRIEGVHVIKKTKSQE
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Catalytic Activity: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate Sequence Mass (Da): 16884 Sequence Length: 150 Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.6.1.17
A9IFD9
MIDKTDITGLILAGGRGSRMGGIDKGLQNYQGMPMAMHALLRLAPQVGQAMVNANRNLGAYEAMGVPVWPDNLPDFAGPLAGLAVGLERCETPYLATVPCDCPRFPLDLVERLAGELARQDADIAMAATLQNGQLRTQPVFCLMKTSLLPSLLAFLQSGQRKIDAWTAMHRCVEVRFDDAAAFAGANTLAELQQLP
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 21065 Sequence Length: 196 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
Q7VY88
MIDKNDITGLILAGGRASRMGSVDKGLQNFHGMPLAMHTLLRLGPQVGDIMINANRNLAAYEAMGAPVWPDALPDFPGPLAGFAAGLERCETPYMVTAPCDTPNFPADMVSRLADALIAEGAQIAMAATTADGALRTQPVFCLMRIDLLDSLLEFLHSGQRKTEIWANQHRCAIVRFDDAQAFAGANTLAELRQLQS
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 21179 Sequence Length: 197 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
A4Z027
MTSSTTTAVPGLLLAGGLARRMGGGDKPMRVIAGRTLLAHVITRLAPQCEPLVLNANGDPARFAAYGLTVVPDDVPGFAGPLAGILAGLDWVASHRPAAQRMISVAADCPFLPRDLVARLTAACMAEDTDLALAASGGHTHPVIGLWPVRLREDLRHALVSEDIRKVTRFTARYKVATVTWPVVPRDPFFNANTAEDLAEAERLAAMEDRDA
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 22565 Sequence Length: 212 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
C0RIT3
MRAGQPKITGAKITGAIIAGGQSSRMQAGGVSGDKFLQPLGSAPVIAHVIARLQPQVDTLFINSKGDLSRFAAFGLPAVKDIAMNHGGPLVGLLTCLAHASPCRLLLTSAADTPFLPCDLASNLIRKQAETGARIILACSNERVHPIVGLWHTDLVPDLEKWLQYAEKASIFWFAKHIGFEVVNIPLAHAPRLAESYDPFFNINLPDDLLKAREINEALQA
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 23761 Sequence Length: 221 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
Q0BH30
MSASPSPSITGLLLAGGRATRMDGADKGLQLLDGTPLALHVLRRLSPQVDETLISANRNADRYAELGAPFDARIVADETADFPGPLAGLLAGMRAARAPLVACAPCDTPYLPADVVARLHAALDAQQADIAMAVTVDAQHARSPQPTFALLRTSLADDLAAALAAGERKVRAWYARHKTVEVEFRDERAFYNANSWHELAALARR
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 21874 Sequence Length: 205 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
Q39I98
MPASASPSIAGLLLAGGRATRMDGVDKGLQLLDGTPLALHVLSRLSPQVDETLISANRHADRYAELGAPFDARIVADETPDFPGPLAGLLAGMRAARAPLVACSPCDTPYLPADLVARLQAALDAQQADIAMAVTVDAQHVRSPQPTFALLRTSLADDLAARLAAGDRKVRAWYARHKTVEVEFHDERAFYNANSWQELAALARR
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 21928 Sequence Length: 205 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
B1JY88
MPAPASPSIAGLLLAGGRATRMDGVDKGLQLLDGTPLALHVLRRLAPQVDETLISANRHADRYAELGAPFDARIIADETPDFPGPLAGLLAGMRAARAPLVACSPCDTPYLPVDLVARLRAALDAQQAAIAMAVTVDAQQVRSPQPTFALLRTSLADDLAARLAAGDRKVRAWYARHKTVEVEFRDERAFYNANSWQELAALARR
Function: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Catalytic Activity: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide Sequence Mass (Da): 22027 Sequence Length: 205 Domain: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. Subcellular Location: Cytoplasm EC: 2.7.7.77
D4GQ17
MSHRQPNRRERGVTRLLPETWRGLTLLLAGVLLLYYLLPIGALVFAQSPASLATDVTNEVVLTAATNSVVAATLSTLVAVAFGVPLAYWLSRTSFRGRDVILALVMLPLVLPPVVSGMLLLRLVGPAGLGQLTSVPLTRSLFGVVLAQTYVASPFLVVTAKTAFDGVDRQLEAAARSLGEDRVGSVRRVTLPLAKQGILAGVTLTFARAIGEFGATLMLAYYPRTLPVQIWVSYLSTGLDAAFPVALVLVGIAVGAILLVHALGTNPWE
Function: Part of an ABC transporter complex involved in molybdenum import (Probable). Responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28536 Sequence Length: 269 Subcellular Location: Cell membrane
Q84MM9
MLRSLHSSSSSDTDNNSGGCKNNGGGGGEAAAAVEGGGDQRAVAAAAPSTRDLLLACADLLQRGDLPAARRAAEIVLAAAASPRGDAADRLAYHFARALALRVDAKAGHGHVVVGGGAARPASSGAYLAFNQIAPFLRFAHLTANQAILEAVDGARRVHILDLDAVHGVQWPPLLQAIAERADPALGPPEVRVTGAGADRDTLLRTGNRLRAFARSIHLPFHFTPLLLSCATTAPHHVAGTSTGAAAAASTAAAATGLEFHPDETLAVNCVMFLHNLAGHDELAAFLKWVKAMSPAVVTIAEREAGGGGGGGDHIDDLPRRVGVAMDHYSAVFEALEATVPPGSRERLAVEQEVLGREIEAAVGPSGGRWWRGIERWGGAARAAGFAARPLSAFAVSQARLLLRLHYPSEGYLVQEARGACFLGWQTRPLLSVSAWQPSSS
Function: Putative transcription regulator that controls rice tillering by initiating axillary buds and promoting their outgrowth. Rice tiller is a specialized grain-bearing branch that is formed on the unelongated basal internode and grows independently of the mother stem (culm) by means of its own adventitious roots. Sequence Mass (Da): 45750 Sequence Length: 441 Domain: The C-terminal part of the protein is important for tillering. Mutant moc1, in which the last 124 amino acids are missing, is mono culm. Subcellular Location: Nucleus
Q9GQ00
MKFIPEITLLLLLFVHSTQAKGKRRKCPEGAWSEGKIMNTIMSNYTKMLPDAEDSVQVNIEIHVQDMGSLNEISSDFEIDILFTQLWHDSALSFAHLPACKRNITMETRLLPKIWSPNTCMINSKRTTVHASPSENVMVILYENGTVWINHRLSVKSPCNLDLRQFPFDTQTCILIFESYSHNSEEVELHWMEEAVTLMKPIQLPDFDMVHYSTKKETLLYPNGYWDQLQVTFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFGTMVELAFVCYISRCQNSVRNAERRRERMRNSQVWANGSCRTRSNGYANGGSVISHYHPTSNGNGNNNRHDTPQVTGRGSLHRNGPPSPLNLQMTTFDSEIPLTFDQLPVSMESDRPLIEEMRSTSPPPPSGCLARFHPEAVDKFSIVAFPLAFTMFNLVYWWHYLSQTFDQNYQ
Function: Functions as a 5-hydroxytryptamine (serotonin) receptor . This receptor is a ligand-gated anion-specific ion channel, selective for chloride ions . Relays a long-range endocrine signal from the body cavity neurons to modulate distal adipose triglyceride lipase atgl-1 function, via the nuclear receptor nhr-76 . Together with the G-protein coupled serotonin receptor ser-1 involved in male mating behavior . May mediate an inhibitory effect of serotonin on egg laying . Involved in regulating locomotory behavior, perhaps by modulating interneuronal signaling, acting in concert with G-protein coupled serotonin receptor ser-4 . In the presence of food, plays a role in initiating and extending dwelling behavior, perhaps acting in AIY, RIF and ASI neurons, in opposition to neuropeptide PDF-mediated signaling . Plays a role in aversive learning upon exposure to pathogens such as Gram-negative bacterium P.aeruginosa strain PA14; perhaps acting in interneurons in response to serotonin released by the serotonergic ADF neurons . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56143 Sequence Length: 489 Subcellular Location: Membrane
O59740
MSALSESPAIPSFWRPETSEISKKPRPNTTVGFQFDNRNVGTSAPSTPAIRRNNTDSFERGLSLPLPSSKQDTGSSVLDPDGDAYVNRYARPVTAGSIYIPSNYHKSFSPNTFSGFNVKRSASKSPKRSANGSTSEDISIEGSPSETAKGARSSFNSNFRTFDIGSERRRRILEASQDSSRPGRYSYRTKSASPALIDTSTLDSRLNFTMGRLERSIAQLSKNTMRAVSHLENPPKDITLPKLNVKNSAWPLQPYSPPANETPASSSSSAKARPVSVPDMSSPVPASSVEYESLKAAVTYSPSQNPKKVAETDSESRKSSFQSSYNDADRPFQVGAQTQSTPNRISRSDSPIVYDVDTHSEDNASTASSEAISQSMRSFQPQPNTGSPFPRFTSTNTEDEQESDIPQSDANDSTVNLNQPNYANLTPTPQVSPKRPTYSRSSPLPSASVPALGDGSPDPPAAPSIQNSLSVHESEMPPHVTRDYTQPAASATPVPKEKPSEKSEKPPKKKGSKLEKFCCILM
Function: With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3. Location Topology: Peripheral membrane protein Sequence Mass (Da): 56542 Sequence Length: 522 Subcellular Location: Cell membrane
Q9H3H1
MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRICRHHMISFVDPLVTNYTVVDFRNRATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNTKPQEMGTEKVIDRKVELEKEDGLVLHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHTEEGGGPLGGPLKFSNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDHNKEPKEKGSPGQNDQELKCSV
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) . Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) . TRIT1 is therefore required for selenoprotein expression . Catalytic Activity: adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA Sequence Mass (Da): 52725 Sequence Length: 467 Subcellular Location: Mitochondrion EC: 2.5.1.75
Q9UT75
MLKPLCVVIGTTGAGKSDLAVQLAKRFGSQVINADSMQIYRGFDTITNKITVEEQENVHHRLMSFLNFDKEYSVPEFERDASRVIDEIHSQGKIPIVVGGTHYYLQSLLFEDTTLSAIDKLTNDSSPSKPPHPDSHILDDDPSAMLSYLKKIDPVMAEQWHPRDTRKIRRSLEIYFHTGRPPSEIYSEQKMKSSGSKLRYKSLIFWAFADSLVLMPRLDKRVDKMLSHGLVDEIKSMKSLAESEKFSPDFTRGIWQCIGFKEFMPWFEAPSDIVFNDCLERMKVSTRQYAKSQKKWIQSRFLPMCLAQQDLSPSSILFSTTNTTDLNNWEEQVEKACRVFQYFFYNGDAIAPSADDQHAFEKARDYLSIMNGRQSQKKKFVCEECLDKRGDPFTVIGEDAFNVHIKSRKHKTTVRRKKERAERQIRLKNIGILK
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Catalytic Activity: adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA Sequence Mass (Da): 50121 Sequence Length: 434 Subcellular Location: Mitochondrion EC: 2.5.1.75
P07884
MLKGPLKGCLNMSKKVIVIAGTTGVGKSQLSIQLAQKFNGEVINSDSMQVYKDIPIITNKHPLQEREGIPHHVMNHVDWSEEYYSHRFETECMNAIEDIHRRGKIPIVVGGTHYYLQTLFNKRVDTKSSERKLTRKQLDILESTDPDVIYNTLVKCDPDIATKYHPNDYRRVQRMLEIYYKTGKKPSETFNEQKITLKFDTLFLWLYSKPEPLFQRLDDRVDDMLERGALQEIKQLYEYYSQNKFTPEQCENGVWQVIGFKEFLPWLTGKTDDNTVKLEDCIERMKTRTRQYAKRQVKWIKKMLIPDIKGDIYLLDATDLSQWDTNASQRAIAISNDFISNRPIKQERAPKALEELLSKGETTMKKLDDWTHYTCNVCRNADGKNVVAIGEKYWKIHLGSRRHKSNLKRNTRQADFEKWKINKKETVE
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP). Catalytic Activity: adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA Sequence Mass (Da): 50237 Sequence Length: 428 Domain: The core aggregation region, although lacking the prion-typical Gln/Asn (Q/N)-rich domain, is required for the formation of the amyloid-like fibrillar aggregates. Subcellular Location: Cytoplasm EC: 2.5.1.75
P39421
MKYSVMQLKDFKIKSMDASVRASIREELLSEGFNLSEIELLIHCITNKPDDHSWLNEIIKSRLVPNDKPLWRGVPAETKQVLNQGIDIITFDKVVSASYDKNIALHFASGLEYNTQVIFEFKAPMVFNFQEYAIKALRCKEYNPNFKFPDSHRYRNMELVSDEQEVMIPAGSVFRIADRYEYKKCSTYTIYTLDFEGFNL
Function: ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA . The ModA-induced ADP-ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters . Catalytic Activity: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide Sequence Mass (Da): 23348 Sequence Length: 200 Subcellular Location: Virion EC: 2.4.2.31
P0A5Y1
MRWIGLSTGLVSAMLVAGLVACGSNSPASSPAGPTQGARSIVVFAAASLQSAFTQIGEQFKAGNPGVNVNFAFAGSSELATQLTQGATADVFASADTAQMDSVAKAGLLAGHPTNFATNTMVIVAAAGNPKKIRSFADLTRPGLNVVVCQPSVPCGSATRRIEDATGIHLNPVSEELSVTDVLNKVITGQADAGLVYVSDALSVATKVTCVRFPEAAGVVNVYAIAVLKRTSQPALARQFVAMVTAAAGRRILDQSGFAKP
Function: Involved in the transport of molybdenum into the cell. Part of the binding-protein-dependent transport system ModABCD. Location Topology: Lipid-anchor Sequence Mass (Da): 26576 Sequence Length: 261 Subcellular Location: Cell membrane
P39423
MIINLADVEQLSIKAESVDFQYDMYKKVCEKFTDFEQSVLWQCMEAKKNEALHKHLNEIIKKHLTKSPYQLYRGISKSTKELIKDLQVGEVFSTNRVDSFTTSLHTACSFSYAEYFTETILRLKTDKAFNYSDHISDIILSSPNTEFKYTYEDTDGLDSERTDNLMMIVREQEWMIPIGKYKITSISKEKLHDSFGTFKVYDIEVVE
Function: ADP-ribosyltransferase that regulates transcription by ADP-ribosylation of host ribosomal protein S1 . Additional identified targets include proteins involved in either translation or cellular metabolism such as elongation factor-Tu or trigger factor . Catalytic Activity: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide Sequence Mass (Da): 24243 Sequence Length: 207 Subcellular Location: Virion EC: 2.4.2.31
P06597
MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVFDRVLQTDVNKEFQMGAKPTTATGNAAAPSTCTARENPAYGRHMQDAEMFTNAAYMALNIWDRFDVFCTLGATSGYLKGNSASFNLVGLFGDNENHATVSDSKLVPNMSLDQSVVELYTDTTFAWSAGARAALWECGCATLGASFQYAQSKPKVEELNVLCNAAEFTINKPKGYVGQEFPLDLKAGTDGVTGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRASFDADTIRIAQPKSATTVFDVTTLNPTIAGAGDVKASAEGQLGDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF
Function: In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42550 Sequence Length: 394 Subcellular Location: Cell outer membrane
F2YTN5
MASNNNCAYELIEAEAQSWDYILSYLRPSCIKCAIQLGIPDILHKNADPIMSLSDLIAALPNLNPSKTTFIPILMRVLVDFGLFNYHQQQGDGYSLTTVGRLLVENHHFGNRSFFLFAQHPVVLNTAASVGDWLKDDLRTAFETADGKSHWDYCGADPEFNGVFNDAMAGDSRLMSNLLISDCCAGVFEGLTSLVDIGGGTGAVAMAIAGAFPSLKCIVLDLPHVIADRKGSGNLEFVAGSMFDKIPHANAILLKWILHNWDDEDCVKLLKKCKESISSRENGGKVIIIDMIMEDNYNNKQLVQSQHLMDLIMRITYASKERTEKEWEKLFLEAGFSGYKIITSLGLRSLIEIYP
Function: Flavonoid 7/4'-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as myricetin derivatives, aroma compounds possessing antioxidant properties and exhibiting pharmacological activities such as anti-carcinogen, anti-viral, anti-thrombotic, anti-diabetic, anti-atherosclerotic, and anti-inflammatory effects . Catalyzes S-adenosylmethionine-dependent regioselective 7/4'-O-methylation of flavonoids; active on various hydroxylated flavonoid substrates, including myricetin, quercetin and kaempferol . Mediates the formation of 4'-methyl derivatives from kaempferol, 3'-methyl quercetin (isorhamnetin), 7-methyl quercetin (rhamnetin) and 3'-methyl myricetin, producing 4'-methyl kaempferol (kaempferide), 3',4'-dimethyl quercetin (4'-O-methyl isorhamnetin), 7,4'-dimethyl quercetin (4'-O-methyl rhamnetin, rhamnacene) and 3',4'-dimethyl myricetin, respectively . Triggers the 7-O-methylation of quercetin, myricetin, 4'-methyl kaempferol (kaempferide), 3-methyl quercetin, 3',5'-dimethyl myricetin (syringetin) and 3',4',5'-trimethyl myricetin, thus leading to production of 7-methyl quercetin (rhamnetin), 7-methyl myricetin, 7,4'-dimethyl kaempferol (7-O-methyl kaempferide), 3,7-dimethyl quercetin, 7,3',5'-trimethyl myricetin (7-O-methyl syringetin) and 7,3',4',5'-tetramethyl myricetin, respectively . Catalytic Activity: quercetin + S-adenosyl-L-methionine = H(+) + rhamnetin + S-adenosyl-L-homocysteine Sequence Mass (Da): 39377 Sequence Length: 355 Pathway: Flavonoid metabolism.
P0DUJ5
MKCIALFLVLSMVVLMAEPGEAFIHHIIGGLFHVGKSIHDLIRGKNRDMAEQQELERAFDRERAFA
Function: The amidated peptide is bactericidal on human pathogens like S.aureus or E.coli, as well as on the fish pathogen A.salmonicida . May also be active against a variety of fungi (By similarity). It can kill bacteria in less than 30 minutes (S.aureus) and 120 minutes (V.vulnificus) . It induces hemolysis of erythrocytes from human and fishes (sea bass and lesser-spotted dogfish) . PTM: This peptide exists in N-terminally amidated and non-amidated forms. The amidated form is more active and has a greater alpha-helix content than the non-amidated form. Sequence Mass (Da): 7508 Sequence Length: 66 Subcellular Location: Secreted
P23848
MTEDLFGDLQDDTILAHLDNPAEDTSRFPALLAELNDLLRGELSRLGVDPAHSLEIVVAICKHLGGGQVYIPRGQALDSLIRDLRIWNDFNGRNVSELTTRYGVTFNTVYKAIRRMRRLKYRQYQPSLL
Function: Activator of the Pm promoter, which controls middle genes expression. Activation of Pm allows expression of protein C necessary for late gene expression. In addition to Mor binding, activation of Pm might require the interaction of Mor with the C-terminus of host RNAP subunits RpoA and RpoH. Sequence Mass (Da): 14714 Sequence Length: 129 Domain: The dimerization domain in the N-terminus and the DNA-binding domain in the C-terminus are connected by a linker containing a beta-strand. Subcellular Location: Host cytoplasm
Q7JQ07
MSSFVPNKEQTRTVLIFCFHLKKTAAESHRMLVEAFGEQVPTVKKCERWFQRFKSGDFDVDDKEHGKPPKRYEDAELQALLDEDDAQTQKQLAEQLEVSQQAVSNRLREMGKIQKVGRWVPHELNERQMERRKNTCEILLSRYKRKSFLHRIVTGDEKWIFFVSPKRKKSYVDPGQPATSTARPNRFGKKTMLCVWWDQSGVIYYELLKRGETVNTARYQQQLINLNRALQRKRPEYQKRQHRVIFLHDNAPSHTARAVRDTLETLNWEVLPHAAYSPDLAPSDYHLFASMGHALAEQRFDSYESVKKWLDEWFAAKDDEFYWRGIHKLPERWEKCVASDGKYLE
Cofactor: Binds 2 divalent metal cations per subunit. Magnesium or manganese. Function: Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site. Sequence Mass (Da): 40851 Sequence Length: 345 Subcellular Location: Nucleus EC: 3.1.-.-
Q07609
MTRTSPRHHAPSETKRRVPMGGVHTNPGKKLTITAVAFQFFINGLVLAAWATSIPHVKNAYSFNDAELGVLLLIMAAGALLFMSLAGYFSHVFGSRRMSIQSALLFPSALVLIFAAPNCMTFLCSIVLFGAANGAMDVLMNHQAKALEENGFPRIMAFLHGCSSTGILAGIMTFGVIGDGHYVARSVTLLTGILIVARWLFPHLLDDVRSGEHRLAIGELRNCKLLMFGILSFLTMVTDGAIAEWSKLYLIRVEQVTDQVGSLGYVAFTLLMIAGRISGDRVKDAIGCRALIAISGSLASAGMTTALFMPSFAGKLAGFALLGLGMANLVPIIFSEAASMNTVSKTVGLTFVSVCGYSGFLVGPPIIGRIAEAVGLGRALLFIIAVGVIVACASVFFDRHRSGQPEP
Function: May be a membrane transport protein that could either transport a precursor for rhizopine biosynthesis into bacteroids or the finished product from the bacteroids. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43216 Sequence Length: 407 Subcellular Location: Cell membrane
P0AF07
MKNQAHPIIVVKRRKAKSHGAAHGSWKIAYADFMTAMMAFFLVMWLISISSPKELIQIAEYFRTPLATAVTGGDRISNSESPIPGGGDDYTQSQGEVNKQPNIEELKKRMEQSRLRKLRGDLDQLIESDPKLRALRPHLKIDLVQEGLRIQIIDSQNRPMFRTGSADVEPYMRDILRAIAPVLNGIPNRISLSGHTDDFPYASGEKGYSNWELSADRANASRRELMVGGLDSGKVLRVVGMAATMRLSDRGPDDAVNRRISLLVLNKQAEQAILHENAESQNEPVSALEKPEVAPQVSVPTMPSAEPR
Function: MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 34186 Sequence Length: 308 Subcellular Location: Cell inner membrane
P56427
MAKKNKPTECPAGEKWAVPYADFLSLLLALFIALYAISAVNKSKVEALKTEFIKIFNYAPKPEAMQPVVVIPPDSGKEEEQMASESSKPASQNTETKATIARKGEGSVLEQIDQGSILKLPSNLLFENATSDAINQDMMLYIERIAKIIQKLPKRVHINVRGFTDDTPLVKTRFKSHYELAANRAYRVMKVLIQYGVNPNQLSFSSYGSTNPIAPNDSLENRMKNNRVEIFFSTDANDLSKIHSILDNEFNPHKQQE
Function: MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 28849 Sequence Length: 257 Subcellular Location: Cell inner membrane
O07887
MARKRRAPRGAAQGWLTTYSDMVTLMLCFFVMLFNPTEVDITVLQSIAASIVGDPTGGGVSASSGRLADLGNTVNTLPSLEKGQKLATALKKAVSLFAPEIKSNKIAVTSDERGLVISLTSDSFFYPGSSDLNVEESREALLRVAQFLSDHALAGRRFRIEGHTDSVEVPEDGSTDNWELSTRRAVRVLHYLTDFGAQENRFSLAGYADTRAKFSNESPEGRAYNRRVDIVILDEGHF
Function: MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 26050 Sequence Length: 238 Subcellular Location: Cell inner membrane
Q98224
MILLENGVRVFPKPGMGKDIYIGLANFGFENDVPELLGVAHLLEHILISFDYTRFVANASTARTYMSFWCRALRAEDYLAALETAVSWFFARGALRTDFSRVRIRNYVRELENEYYFRNEVFHCMDILTFLGGGDLYNGGRLSMLEQLDAVRELLGKRMRRLAGPNVVIFVRELSPAALALLERSFGTLPRFPSTIPATRLGSIHNKAVLVPAPFYALLIQVDNTVENVLAVICLAESYHFVDYETLGERLYVSFAFVHEQDCEAFLRNVGELRFEPAPRVELNYSDDYVMNLYVNFPWLQHDLADYLYTLNADCVPLLRGLEENLRRSVRERQLVVVYPSFSPSLFNSRDRQDHRLLVLDVDLARSAGPARVPRTFRRQPRAEVFVRYGDPALLDYVAFALARPRAAALRRLPRGVRLAHGFSHADMHEIMASETFIKYSRSRPAALFQYIFLAFFATGRSIAEILERREALVSFDARRCVNRLVFAKRARYDVVTKSSFVCGVLRGPRLSEAALTRAMWELKRKGLLYSLEHTRMHAKHTFYVFAFSIYPEQVYRYFARWQLVSKHCCVVSMRGEREDYSALRKEVVVNFV
Cofactor: Binds 1 zinc ion. Function: Seems to be involved in viral proteins maturation by cleavage at Ala-Gly-|-Xaa motifs. Sequence Mass (Da): 68420 Sequence Length: 593 EC: 3.4.24.-
Q59XX2
MLFKSFVTFTVLANALAAPLAHQHHQHKEEKRAVHVVTTTNVVVVTIGNGDQTTTFAAPSVAAESSVSVSVNTEPPQNHPTTTQDVASASTYPSSTDGSAASSSAAASSSSQAGSEPSGGVGSGGAKGITYSPYSDNGGCKSESQIASEIAQLSGFDVIRLYGVDCSQVEAVLKAKTSSQKIFAGIFDVSSITSGIESLAEAVKSCGSWDDIYTVSIGNELVNAGSATPSQIKAYVEEGRKALKAAGYTGPVVSVDTFIAVINNPDLCDYSDYMAVNAHAFFDGHVVAENSGAWVLQQIQRVWTACGGKKNVLITETGWPSRGDSNGVAVPSKSNQQAAISSIKSSCGASAILFTAFNDLWKADGPYNAEKYWGIYSN
Function: Surface mannoprotein required for hyphal morphogenesis, surface adherence, and pathogenicity. Contributes in a high proportion to the carbohydrate component of the matrix due to high levels of glycosylation and may play important roles during biofilm development and maintenance. Acts as a major antigen target of host cell-mediated immune response. Induces extensive T-cell proliferation of human peripheral blood mononuclear cells. Facilitates host dendritic cells maturation and promotes cytokine production through its glycosylated portion while its protein core is essentially involved in induction of T-cell response. PTM: Glycosylated protein with a polysaccharide moiety composed exclusively of mannose and glucose at a ratio of 12.7 to 1. Contributes highly to the carbohydrate component of the matrix. Treatment with tunicamycin impairs glycosylation. Sequence Mass (Da): 39264 Sequence Length: 378 Subcellular Location: Secreted EC: 3.2.1.-
P89035
MATGKCYCPEDPRVGPLLVLCLLLLLILFSRSWNVAPVVVPSYHTVYHHEKYQNIEIQK
Function: Cell-to-cell movement. Location Topology: Single-pass membrane protein Sequence Mass (Da): 6797 Sequence Length: 59 Subcellular Location: Membrane
Q7KSC4
MSIRRAMSTTASKEWRDYFMSTHFWGPVANWGIPVAALADTQKSPKFISGKMTLALTLYSCIFMRFAYKVQPRNWLLFACHATNATAQSIQGLRFLHYNYGSKEQQA
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12261 Sequence Length: 107 Subcellular Location: Mitochondrion inner membrane
Q9Y5U8
MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDMKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHATNEVAQLIQGGRLIKHEMTKTASA
Function: Mediates the uptake of pyruvate into mitochondria. Catalytic Activity: H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12347 Sequence Length: 109 Subcellular Location: Mitochondrion inner membrane
P63030
MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDMKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHVTNEVAQLIQGGRLINYEMSKRPSA
Function: Mediates the uptake of pyruvate into mitochondria. Catalytic Activity: H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12455 Sequence Length: 109 Subcellular Location: Mitochondrion inner membrane
O74847
MNASEKLSQKAAQSVTRRFITWLKSPDFRKYLCSTHFWGPLSNFGIPIAAILDLKKDPRLISGRMTGALILYSSVFMRYAWMVSPRNYLLLGCHAFNTTVQTAQGIRFVNFWYGKEGASKQSVFENIMQAAKHPESGTRQK
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 16056 Sequence Length: 141 Subcellular Location: Mitochondrion
P53157
MSQPVQRAAARSFLQKYINKETLKYIFTTHFWGPVSNFGIPIAAIYDLKKDPTLISGPMTFALVTYSGVFMKYALSVSPKNYLLFGCHLINETAQLAQGYRFLKYTYFTTDEEKKALDKEWKEKEKTGKQ
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14995 Sequence Length: 130 Subcellular Location: Mitochondrion
Q8L7H8
MATSKLQALWNHPAGPKTIHFWAPTFKWGISIANIADFQKPPENISYLQQIAVTCTGMIWCRCSTIITPKNWNLFSVNVAMAATGIYQLTRKIKYDYVSEAEAAVEIEG
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12222 Sequence Length: 109 Subcellular Location: Mitochondrion inner membrane
O01578
MGPHRLLYQALCKAGDKFVYPVLPAFAKPAWNHAAGPKTVFFWAPTIKWTLIGAGLADLARPADKLSLYQNSALFATGAIWTRYCLVITPINYYLSSVNFFVMCTGLAQLCRIAHYRYQNPDWETKEIMETHN
Function: May mediate the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 15074 Sequence Length: 133 Subcellular Location: Mitochondrion inner membrane
Q55GU3
MNALRGLLNKYTGNQIVFSNKYATTFFEKFPKLAFLNNVTNLAPMMKWSLSIVPITQILSGTKLPENIDVYQASSLCATGSIWTYYATLISPQNTGTRMLAACNAAMAACHGYNIYRRTKWEKSQIIPIENKN
Function: May mediate the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14936 Sequence Length: 133 Subcellular Location: Mitochondrion inner membrane
O95563
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
Function: Mediates the uptake of pyruvate into mitochondria. Catalytic Activity: H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14279 Sequence Length: 127 Subcellular Location: Mitochondrion inner membrane
Q09896
MFRAGFKRFWNHPAGPKTVHFWAPAMKWTLVLSGIGDYARSPEYLSIRQYAALCATGAIWTRWSLIVRPKNYFNATVNFFLAIVGAVQVSRILVYQRQQKRITAQSEQRTELARSLAA
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13536 Sequence Length: 118 Subcellular Location: Mitochondrion inner membrane
P38857
MSTSSVRFAFRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR
Function: Mediates the uptake of pyruvate into mitochondria. Catalytic Activity: H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14555 Sequence Length: 129 Subcellular Location: Mitochondrion
Q8LD38
MATSKLQALWNHPAGPKTIHFWAPTFKWGISIANIADFQKPPETLSYPQQIVITGTGLVWSRYSTVITPKNWNLFSVSLGMAVTGIYQLTRKIKHDYVYEANSIVAKE
Function: Mediates the uptake of pyruvate into mitochondria. Negatively regulates ABA-induced guard cell signaling and mediates drought stress responses. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12181 Sequence Length: 108 Subcellular Location: Mitochondrion
P53311
MSASAFNFAFRRFWNSETGPKTVHFWAPTLKWGLVFAGLNDIKRPVEKVSGAQNLSLLATALIWTRWSFVIKPKNYLLASVNFFLGCTAGYHLTRIANFRIRNGDSFKQVIHYIIKGETPAAVAAKQTASTSMNKGVIGTNPPITH
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 16230 Sequence Length: 146 Subcellular Location: Mitochondrion
O49636
MATSKLQAIWNHPAGPKTIHFWAPTFKWGISIANIADFAKPPEKLSYPQQIAVTCTGVIWSRYSMVINPKNWNLFSVNVAMAGTGIYQLARKIKHDYATEAEPAVASE
Function: Mediates the uptake of pyruvate into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 12005 Sequence Length: 108 Subcellular Location: Mitochondrion inner membrane
Q4WUN7
MAEFVRAEVLGTKFEYTTRYVNPQPIGMGSFGLVCSAFDQITQQPVALKKIMKPFDSSSLAKRTYREIRLLKYLRHENLICMRDIFISPLEDIYIATELLGTDLGRLLSIKPLDSKFSQYFIYQILRGLKYIHSANVIHRDLKPTNILINENCDLKICDFGLARLQEPQMTGYVATRYYRAQEIMLTWQRYGVQVDVWSAGCILAEMLRRKPLFPGKDHVHQFHLITNILGNPPDAVIEKITSKNTVNFVKSLPSREPRDLSTVVPKDTDFDAIDLLKKMLVIDPDTRISAQDALRYPYLAPYHDPTDEPVASGPFDWSFDSADFPKETWKIMIYSEVLDYLNVDNPADPAPFDPSTPFDPSALEREFSEFLSDSGQI
Function: Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source. PTM: Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 43308 Sequence Length: 378 Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. EC: 2.7.11.24
Q55CS7
MIFKKLFSKGSTSPTTRPRGATFSGTFPTDVLSDDGSGTNTNGLSNSTTNPSSIHSTPTTPTTTASTNLTNSNKLSTLAPITNGNRSLRGSKDGSGTTKESKKKVLTLNEKQKLLLKSMEYIKGSGTYYGNYMEFYEIPIQIYVGTEPSETYPSLSYNTELRSLILDFNKITEIPEQIGLLPNLKHLSLAANQLSQVPEFLSQLKSLESLELGINQFTSFPLNICKIKSLTLLRLETNNIKSLPDDFINLENLKDLSLLDNQLKEIPDSLPNNIEKLNLGCNDIINSYSKSLIRISHSLTTLNLSENKIEVLDESLSCLVNVKTLILDCNMIKVIPGSVLGSWKSLVTLNLPHNFISDLPAEIVTLDNLRIIDLRGNNFEFCKNYPSSESSSILFKIEEFIKDKEKLKSLILKENLEILSKLKDDNSTTTTTNINSNLDVPIIITTNIETIPTTSTTATTTETTNDITFKISDITEIIEKTDTTTTTTTTNQTDNVKLEEKVYEKQENDENNSVTLETTTTISIASDNTDEASIQIPQKEDGDKENLENDDKLLQESFSENNNNNNNEKQQEQQENPLKESQGKIQQLEEELEKLEQKQLELKDKIRLEKIKYQEIQQQSPRLSQQENNQEAIVVNTQPSSPPPTIIVNEQKSEKLENEKPTKREQPMVVVTKNNNKAEVEMTAPNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLSK
Function: Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 94023 Sequence Length: 834 EC: 3.1.3.16
Q54Y32
MGNSHSSENGGNSGSGGGSGGGGSGYSGVSENMIIDLEGRYHIDYKNRNYKKLKPQMFSTFFEHYEIVQADSLINSDFIKNKTVKKNRDNSSNNNSNNNSNNNNNNNTLNNSTIITTTTTTTTTSTPTTTIMITPPQQQQQQRTSLDLTNRDISESSTPNEQQIRLAQEETENQEIVESSFLKSSPVPSPSSSVLKSFESDFQLNTDLTTETFDDNSAEKKRQQQQQQQQNEDSKQSSQQQTQKSKDKDESAKIVNNKSSSTTNIKPILAAAQTSRSTSIPAFNRNKTKEPTKQKIKKEHSTLRKNSLSSSNIITPNNTTNTNAKDGASYFNENSLMSVKSDIKIFSLDLSINRLENITNDILSIMARFEIQELTLSTNFFQIIPDLQLVKSLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIPDDIDQIKNLKYLSIKHNALEYLPNSLSNLSQLISLDLSQNKLKTLPPNFDDLINLRMVWLSYNQITSLPSMRKLVNLVTFDISSNKLLSLPKDFAYLVPSRIKQSYSDIDIDEYDENINTCNNINSNNNDSNNSNNNNNNNNDNNNNCNKNNILEMINSTELEGGGLGCLKELNIRDNRELISLPVEYKQVESLMTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNILNISSHNSNNKNNNSSNNRKSINNRKSNNIIITINNSSNSNNNNSTDNSNNSSTSTTPNLSSLSSDSSSSASLSKLSISK
Function: Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 95418 Sequence Length: 856 EC: 3.1.3.16
Q8TAP9
MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC
Function: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. PTM: Phosphorylated during mitosis in the cell cycle probably by CDK1. Sequence Mass (Da): 19147 Sequence Length: 179 Subcellular Location: Nucleus
P37773
MRIHILGICGTFMGGLAMLARQLGHEVTGSDANVYPPMSTLLEKQGIELIQGYDASQLEPQPDLVIIGNAMTRGNPCVEAVLEKNIPYMSGPQWLHDFVLRDRWVLAVAGTHGKTTTAGMATWILEQCGYKPGFVIGGVPGNFEVSAHLGESDFFVIEADEYDCAFFDKRSKFVHYCPRTLILNNLEFDHADIFDDLKAIQKQFHHLVRIVPGQGRIIWPENDINLKQTMAMGCWSEQELVGEQGHWQAKKLTTDASEWEVLLDGEKVGEVKWSLVGEHNMHNGLMAIAAARHVGVAPADAANALGSFINARRRLELRGEANGVTVYDDFAHHPTAILATLAALRGKVGGTARIIAVLEPRSNTMKMGICKDDLAPSLGRADEVFLLQPAHIPWQVAEVAEACVQPAHWSGDVDTLADMVVKTAQPGDHILVMSNGGFGGIHQKLLDGLAKKAEAAQ
Function: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate. The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioyl-D-alanyl-D-alanine in vivo and in vitro. Catalytic Activity: ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate Sequence Mass (Da): 49874 Sequence Length: 457 Pathway: Cell wall biogenesis; peptidoglycan recycling. Subcellular Location: Secreted EC: 6.3.2.45
Q08CH3
MGSEPPSSPQVVEEGADEEDEELSGAEDADLRSSSGRGSLLTRRGITLRVLLKDGLVEPGDGVLSIHYLGKKFVGDLLNDGKIRWVETGQIFNSPSAWATHCKRLVNPAKKSGCGWASVRYRGQKLVQYKTTWLHKYQPSADMSLISEGEDDEMGDDDEEEGKTTIPVEDKNKKSKPELHEIGLTQRRDRERIPVRYCTLGTRDAARDPHTLVELSAFSAINRFQPFNVAVSSNVLLLMDFHCHLTSSEVVGYLGGRWDTNTQLLTVLRAFPCRTRLADKDAAPAVEEEICQNLFMRGLSLVGWYHSHPRGPALPSLQDIDSQMDHQLRLQGSSNGFQPCLGIICGPYYHGNQGVASTITPFWVVPPPEQRPNDHGIPVAVEVTYVQDNFLTTDVLNEMMLLVEFYRSAPDLVQFSQMWSPNTSILDKIKASLSGHAPKDQAYAQILEHVYNQLRNTQ
Function: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). PTM: Degraded following binding to N(6)-methyladenosine methylated DNA (m6A). Sequence Mass (Da): 51102 Sequence Length: 458 Domain: The RAMA domain recognizes and binds N(6)-methyladenosine methylation on DNA (m6A). EC: 3.4.-.-
C0H3X7
MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVINGLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFGGLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEKPWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTVIYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAIVTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAVLVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLILPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAIIIVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDGNALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYHDFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEELKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEISVDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAAVIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV
Function: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides. Catalytic Activity: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 96322 Sequence Length: 856 Subcellular Location: Cell membrane EC: 2.3.2.3
Q2G2M2
MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK
Function: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides. Consequently, MprF is shown to affect resistance and susceptibility to moenomycin and vancomycin, resistance to human defensins (HNP1-3) and evasion of oxygen-independent neutrophil killing and susceptibility to methicillin, oxacillin, bacitracin, gentamicin, beta-lactams and synthetic peptides (hBD3, CAP18) and other cationic antimicrobial peptides. Catalytic Activity: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 96866 Sequence Length: 840 Subcellular Location: Cell membrane EC: 2.3.2.3
Q7ZVH1
MLNLIKLPQVFTINQVPKVFHEDGIISGYRHPCSSAKDCVLSLFQLTNETLNIWTHFLPTWFFLWKLLTVVLVLEDWRDPFIWPFLVFLLSCCVYPLASSCAHTFSTMSERARHICFFFDYGALSFYSLGSAIIYSSYSFPDKWVNGTFHLNYVSIAVVNSIISTALACYSRLGLPFLEYNCHSIKRPSGKLDQKLCKCLRIIAFVYPYLFDNIPLFYRIFVCAGEGCTVNEANTVHYQHTSLAFFTGFLFATHLPERLAPGSFDYIGHSHQLFHVFAIIGTYFQMTAIELDMAARKQWLHAHLPPVTFLNTVGAAFFSVVSGLCIVYVFSLSLFSTRGVKNKSF
Function: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39356 Sequence Length: 345 Subcellular Location: Membrane
Q6DC77
MLSLIKLQRVFNVHQVPKAFHEDGIISGYRHPRSSATECVWSLFQLTNETLNVWTHFLPTWYFLWKLMTVLLMEDVWNEAYTWPLLVFLFSCCVYPLASSCAHTFSSMSTRARHICYFFDYGALSFYSLGSAISYSAYVFPDAWLSSSFHAYYISVAVFNTVLSTSLACYSRLGLPLLHYSHDIVERFSERQCPRMSKVLRILAFAYPYLFDNIPLFYRLFVCVGEGCTDNEANSVHVQHTLLAFLTSFLFATHLPERLAPGRFDYIGHSHQLFHVCAIIGTHFQMKAIEMDMGLRRSQLLASAPAISFNNTIGAALLCVSVSLGIICVYSLPLLYSSNPKNTANKE
Function: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39519 Sequence Length: 347 Subcellular Location: Membrane
Q81C25
MQQKTDVILIGAGIMSATLGSLLKELAPEWEIKVFEKLASAGEESSNEWNNAGTGHSALCELNYTSEKADGSIDISKAVKVNEQFQLSRQFWAYLVKSKLIRNPQDFIMPLPHMSLVQGKKNVEFLKNRFEALSKNPLFQGMEFSDAPETLKKWLPLIMEGRTSNEPMAATKIDSGTDVNFGALTRMLFDYLKTKNVELNYKHSVENIKRTKNGLWEVKVHDMNSGKIEHHTAKFVFIGGGGGSLPLLQKTGIPESKHIGGFPVSGLFMVCKNQKVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKALLFGPFAGFSPKFLKTGSNLDLIGSVKPNNVLTMLAAGVKEMGLTKYLIQQVMLSHEKRMLDFPAFIPNAKSEDWDIVVAGQRVQVIKDTDAGGKGTLQFGTEVVSAADGSIAALLGASPGASTAVHVMLEVLEKCFPSRMIEWEEKIKEMIPSYGISLTENPRLFQDLHTSTGRTLGLNEKETVHN
Catalytic Activity: (S)-malate + a quinone = a quinol + oxaloacetate Sequence Mass (Da): 54803 Sequence Length: 497 Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. EC: 1.1.5.4
Q6NGC5
MTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGGIAILIGITVAYAVTGIVGQVTGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGLNKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLRDLPTVDLAIGPKAVGIAIFLLFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRDPLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGALFVLEAASVVIQVAGYRTKKIRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGASIFYGEWLSLTGV
Function: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I. Catalytic Activity: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38273 Sequence Length: 366 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell membrane EC: 2.7.8.13