ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
F7IX06
MSVTTPRRETSLLSRALRATAAAATAVVATVALAAPAQAANPYERGPNPTESMLEARSGPFSVSEERASRFGADGFGGGTIYYPRENNTYGAIAISPGYTGTQSSIAWLGERIASHGFVVIAIDTNTTLDQPDSRARQLNAALDYMLTDASSAVRNRIDASRLAVMGHSMGGGGTLRLASQRPDLKAAIPLTPWHLNKSWRDITVPTLIIGAEYDTIASVTLHSKPFYNSIPSPTDKAYLELDGASHFAPNITNKTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTGLLSDVEEYRSTCPF
Cofactor: Can also bind other divalent metal ions with lower efficiency . Calcium ion binding contributes to the thermostability of the protein . Function: Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle . Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters) . Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world (By similarity). Can also depolymerize the synthetic polyesters poly(epsilon-caprolactone) (PCL), poly(butylene succinate-co-adipate) (PBSA), poly(butylene succinate) (PBS), and poly(lactic acid) (PLA) . Catalytic Activity: an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+) Sequence Mass (Da): 32353 Sequence Length: 300 Subcellular Location: Secreted EC: 3.1.1.74
Q85FM5
MDSVTIAWAALMAISTFSLSLVVRGRSGL
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. Location Topology: Single-pass membrane protein Sequence Mass (Da): 3054 Sequence Length: 29 Subcellular Location: Plastid
P61039
MDIVSLAWAALMVVFTFSLSLVVWGRSGL
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. Location Topology: Single-pass membrane protein Sequence Mass (Da): 3170 Sequence Length: 29 Subcellular Location: Plastid
O14136
METNQNEKGPSLPSYPAGGIMSVSNSNADTNQGVTQHPLANRIVNPNYYNMGFNPYSGFNSFIPSFNPFVPLETNLPGNGPISSLQVIESIVGAVGSIAQVLESTLMAAHMSYNTFVSVSENLNKLKSSIGAIFGIVSLLSRLKRLVLKFFKHSKIDEMNSQEYDVFEKEEGNHKNSIYSIVSSLAIILGLVGLPYAIIRLFKNIYEKEKQIQQAKIRKKIDSLEFCKADYEFMSRDPGVEMSLKKGDIIAILSKTDTQGNPCEWWQGRKRSGETGWFPSNYCSIISR
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Location Topology: Single-pass membrane protein Sequence Mass (Da): 32055 Sequence Length: 288 Subcellular Location: Peroxisome membrane
P80667
MSSTAVPRPKPWETSASLEEPQRNAQSLSAMMTSNQQDSRPTEESNNSNSASESAPEVLPRPAALNSSGTYGESNTIPGIYGNSNYGIPYDNNPYSMNSIYGNSIGRYGYGGSYYGNNYGSFYGGGYGAGAGYGMNNGSGLGESTKATFQLIESLIGAVTGFAQMLESTYMATHNSFFTMISVAEQFGNLKEMLGSFFGIFAIMKFLKKILYRATKGRLGIPPKNFAESEGSKNKLIEDFQKFNDSGTINSNEKATRRKISWKPLLFFLMAVFGFPYLLNKFITKLQTSGTIRASQGNGSEPIDPSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIEIIKRRKKIEHVDDETRTH
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX21 receptors . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm . Mechanistically, PEX5 (or PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Location Topology: Single-pass membrane protein Sequence Mass (Da): 42706 Sequence Length: 386 Subcellular Location: Peroxisome membrane
Q9FXT6
MATHQQTQPPSDFPALADENSQIPEATKPANEVQQATIAQDPPTSVFKNSEPIREDQIQNAIKFLSHPRVRGSPVIHRRSFLERKGLTKEEIDEAFRRVPDPPPSSQTTVTTSQDGQQAVSTVQPQAMQPVVAAPAPLIVTPQAAFLSRFRWYHAILAVGVLAASGAGTAVFIKRSLIPRFKSWVQRIMLEEETDPLKKADAKPSLAEEAVAAAKAASAAASDVARVSQEMMITKNEERKYFEDLTHLLGVQVQEMKSLSNNIRKLEGQSNNIPKIYSADQEVYNGSVTTARKPYTNGSNVDYDTRSARSASPPAAPADSSAPPHPKSYMDIMSMIQRGEKPSNIREINDMPPNPNQPLSDPRIAPKSKPWDYGQAPQDESSNGQWWQQKNPRSTDFGYETTTAARFTANQNETSTMEPAAFQRQRSWVPPQPPPVAMAEAVEAIRRPKPQAKIDQEAAASDGQSGVSDELQKITKFSESGGDGSGGIKIAEIQEETEQQHISQEGN
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 55595 Sequence Length: 507 Subcellular Location: Peroxisome membrane
Q54C55
MDNDDINNNNNNNNNNNNNNNSQELDQQEQTQEEITKQRIQKRKEEAKRIMEERKKREQQPPSQRQYEDVEDDQQQQPIRPIKQLPQRQQQYDDNDEPPQQQQYEPKISQRKVPLPPMKQPTTSSTASAATGSILSPSSNFREDMVKKAVLFLNNPNVKNTALARKVAYLEKKGLTSDEVKEALKRVETGNINGSSTNNSNITQSNSISRTRNDNYGNNNNNSSNNNNNIQQQQYYQQQQQQHQQQQQMALTQIQSYQKRLEADDQRIAQLMMNNNRFSWNSFLFSVTAIVGAASGLAYLTSNYIIPFLNGGKTNKDASANMDKKITSLQEEIIKLQSTIIQQGNDFRESTKSLKTLIEQQQQQILQQQQINSVSTTTNSATSASNSSEIVEIKKELKNLINLIGNKENSNNSNNNSNNSNNNNGYSKYNGFNGVYNKSSYDDVSTNNNNKTNSPPSPNKPTTTTTTTATSTPGSNISNTNKTLPPIIKTNPYSHLSWKLPTDQPPVIPSWQQKSSNPPSDLSNANDKSSPSNSNPSTPTKPYQSSFNYGDVNSFVGGSNTLNFDEKPTTTTTTSTTPSNERPSSPSVNNNNNNNNNNNNNNNNNNNNNNNTTIASTSNESNNSKVETTSNDSDKSTSPSSSSNNTTSTTATTTTITSASTEDNKQQSDETPYSSDFLDVINQLKQGKTPPGIRTDIDDKPLENSTVTKSAKERPKKPWERDTLTSVTNNLSVEETQTINNTDSSVEK
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 83361 Sequence Length: 748 Subcellular Location: Peroxisome membrane
O75381
MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Plays a key role for peroxisome movement through a direct interaction with tubulin . Location Topology: Single-pass membrane protein Sequence Mass (Da): 41237 Sequence Length: 377 Subcellular Location: Peroxisome membrane
Q9R0A0
MASSEQAEQPNQPSSPPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSPLGPATPVVPVQPPHLTPQPYSPRGSRWRDYGALAIIMAGIAFGFHQLYKRYLLPLILGGREDRKQLERMAASLSELSGTVAQTVTQVQTTLASVQELLRQQQQKVQELAHELATAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSSSPSSPAAVNHHSSSDISPVSNESTSSSPGKDSHSPEGSTATYHLLGPQEEGEGVLDVKGQVRMEVQGEEEKREDKEDEDDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNETERD
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 41208 Sequence Length: 376 Subcellular Location: Peroxisome membrane
P78723
MSQQPATTSRAELVSSAVEFLLDQSIADSPLAKKVEFLESKGLTQQEIEEALQKARTGTVQASPSQQSVVPPRPPVPDYYPSAPPLPERDWKDYFIMATATAGISYGVYQFVKRYVVPKILPPSKTQLEQDKAAIDHEFQRVESLLEKFEADQKEFYQKQEAKSKKIDETLQEVDEIINKTNEKNLNNEETLKYLKLEIENIKTTLLKTLDSQKATLNAELSAMEKQLQDIKFDIKTSGIAVAPQLSTPPSESTSRQSPAAEAKPKINLNIPPTTSIPSLRDVLSREKDKDVNSDSIAQYEQRTANEKDVERSIPAWQLSASNGGSSTTSGVAGDEQKEPKRGIPAWQLNA
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Location Topology: Peripheral membrane protein Sequence Mass (Da): 39034 Sequence Length: 351 Subcellular Location: Peroxisome membrane
Q9HG09
MSSIREEMVTSAVEFLKNPQIADSPLAKKIEFIESKGLNEAEVKEALLRSQGGNGSSSVASQVSSYSPSASQSSVAPSPPPFPDHYRNAPPLPERDWKDYFVMATATAGVSFGLYKVISNYVLPKLLPPSKEAIELDKEAIDREFTRVEALLNTFEEDQKAFYEEQREKSGKIEDTLTEIDAIISKTNEKNLNNEESLKYLKLEIESIKNTLMKNIDSQKSTISSELGSIEAQLDELKKLIVAKPEDEPIRAAPQPSLTTGANSLTSESSGRSSIPHSQSVPIRTQLTTPPSDSDTSGPAKLHIPPATSIPSLKDILRKEKNRTVDTFSKSNLGKDLESVAQSDPDKVEKYEGRRDLKSLERPEEDEKKEDDVEDGGDKDKLASSLESVKLPPSSEQVQAPAPKERTSSSSSRSGIPAWQLAAQS
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX20 receptors . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 (or PEX20) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity). PTM: Phosphorylated on serine or threonine residues. Location Topology: Peripheral membrane protein Sequence Mass (Da): 46589 Sequence Length: 425 Subcellular Location: Peroxisome membrane
O60065
MREDLLRNSVEFLREKTVLDAPDVKKIEFLKSKGLTAEEIQEAFKLAKNPLFPSYPRFENTSNFVSRDWRDWFIMGVISTGFAWSAYSLVKKYIAPMFRAPSQNAYEADKNALDAKFLEAHKILENLDEQTRKLSERTEKQQDELDIALDDLEETLNTLKRTSENRDREIARISQDVYTMSTITLPQSLEQIKKSQEEALQNLSREISSLRCLQTDSKKDDTFATTSNSSIPVLENPLDTSEGFQTKKVGTASLPDWQISMHNEASKNIDFNDIDPAESYVAEDAY
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Location Topology: Peripheral membrane protein Sequence Mass (Da): 32814 Sequence Length: 286 Subcellular Location: Peroxisome membrane
P53112
MSDVVSKDRKALFDSAVSFLKDESIKDAPLLKKIEFLKSKGLTEKEIEIAMKEPKKDGIVGDEVSKKIGSTENRASQDMYLYEAMPPTLPHRDWKDYFVMATATAGLLYGAYEVTRRYVIPNILPEAKSKLEGDKKEIDDQFSKIDTVLNAIEAEQAEFRKKESETLKELSDTIAELKQALVQTTRSREKIEDEFRIVKLEVVNMQNTIDKFVSDNDGMQELNNIQKEMESLKSLMNNRMESGNAQDNRLFSISPNGIPGIDTIPSASEILAKMGMQEESDKEKENGSDANKDDNAVPAWKKAREQTIDSNASIPEWQKNTAANEISVPDWQNGQVEDSIP
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX21 receptors . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm . Mechanistically, PEX5 (or PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Location Topology: Peripheral membrane protein Sequence Mass (Da): 38420 Sequence Length: 341 Subcellular Location: Peroxisome membrane
Q08215
MAASEIMNNLPMHSLDSSLRDLLNDDLFIESDESTKSVNDQRSEVFQECVNLFIKRDIKDCLEKMSEVGFIDITVFKSNPMILDLFVSACDIMPSFTKLGLTLQSEILNIFTLDTPQCIETRKIILGDLSKLLVINKFFRCCIKVIQFNLTDHTEQEEKTLELESIMSDFIFVYITKMRTTIDVVGLQELIEIFIFQVKVKLHHKKPSPNMYWALCKTLPKLSPTLKGLYLSKDVSIEDAILNSIDNKIQKDKAKSKGKQRGVKQKIHHFHEPMLHNSSEEQVKVEDAFNQRTSTDSRLQSTGTAPRKKNNDITVLAGSFWAVLKHHFTRSVLNKNGLLLTGLLLLLCLKKYKSLMAIFKHVPAAFHTVYPQIVGLLKLLASI
Function: Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes . PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane . PTM: Phosphorylated. Location Topology: Single-pass membrane protein Sequence Mass (Da): 43676 Sequence Length: 383 Subcellular Location: Peroxisome membrane
Q8S8S1
MEAYKQWVWRNREYVQSFGSFANGLTWLLPEKFSASEIGPEAVTAFLGIFSTINEHIIENAPTPRGHVGSSGNDPSLSYPLLIAILKDLETVVEVAAEHFYGDKKWNYIILTEAMKAVIRLALFRNSGYKMLLQGGETPNEEKDSNQSESQNRAGNSGRNLGPHGLGNQNHHNPWNLEGRAMSALSSFGQNARTTTSSTPGWSRRIQHQQAVIEPPMIKERRRTMSELLTEKGVNGALFAIGEVLYITRPLIYVLFIRKYGVRSWIPWAISLSVDTLGMGLLANSKWWGEKSKQVHFSGPEKDELRRRKLIWALYLMRDPFFTKYTRQKLESSQKKLELIPLIGFLTEKIVELLEGAQSRYTYISGS
Function: Involved in the formation of peroxisomes, lipid bodies and protein bodies. PTM: The detection of an additional immunorelated polypeptide of 52 kDa suggests a post-translational modification of PEX16. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 41611 Sequence Length: 367 Domain: The internal domain (235-279) containing two internal membrane helices and the intervening residues that include the basic cluster VRS is sufficient for targeting recombinant proteins to endoplasmic reticulum and then to peroxisomes. Subcellular Location: Peroxisome membrane
Q2KII7
MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFADSHELSELVYSASNLLVLLNDGILRKELRKKLPMSLSQQRLLTWLSVLECVEVFMEMGATKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKAGLQTSPPIVPLDREIQAQSRDGDHSSGSQEQSYVGKRSNRVVRTLQNTPSLHSRHWGAPQQREELGVAPTPLGLQETIAESLHIARPLLHLLSLGLWGQRSWTPWLLSGVVDVTSLSLLSDRKGLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHVPGIGLVTRPLMDYLPNWQKIYFYSWG
Function: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37574 Sequence Length: 328 Subcellular Location: Peroxisome membrane
Q4QRH7
MEKLTRVFERYQEYVRTSPAAASHLESTVRALSYLIAGRFSDSHEISELVYSASNLLVLLNDGILRKNLSRTLPMSISQQKLLTWLSVLEYVEVFVEMAAAKMWGDAGRWLVIVLIQIAKAVLRCLLLFWYKSGIQTSPPIIPLDRDSQLCSQDNNEEEDDEDSSFVGQRSGRVVRPLGSAPSLQSRLWGLPRKKKVSRNQEEELHSSPTPLGLQETIAESLYIARPLLHLASLGICGKRSWKPWILSGLLEITSFSLLSDMKALNRRERAEMRRRAFLLLYYLLRSPFYDRYSETKILFLLRFLADYVPGVGLVARPLMEYLPIWQKIYFYNWG
Function: Involved in peroxisome biogenesis. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38555 Sequence Length: 335 Subcellular Location: Peroxisome membrane
Q9Y5Y5
MEKLRLLGLRYQEYVTRHPAATAQLETAVRGFSYLLAGRFADSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALVQLAKAVLRMLLLLWFKAGLQTSPPIVPLDRETQAQPPDGDHSPGNHEQSYVGKRSNRVVRTLQNTPSLHSRHWGAPQQREGRQQQHHEELSATPTPLGLQETIAEFLYIARPLLHLLSLGLWGQRSWKPWLLAGVVDVTSLSLLSDRKGLTRRERRELRRRTILLLYYLLRSPFYDRFSEARILFLLQLLADHVPGVGLVTRPLMDYLPTWQKIYFYSWG
Function: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38629 Sequence Length: 336 Subcellular Location: Peroxisome membrane
Q91XC9
MEKLRLLSLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMLLLIWFKAGIQTSPPIVPLDRETQAQPLDGDHNPGSQEPSYVGKRSHRVVRTLQNSPSLHSRYWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWTPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLTDHIPGVGLVARPLMDYLPSWQKIYFYSWG
Function: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38677 Sequence Length: 336 Subcellular Location: Peroxisome membrane
A7MAS3
MVTKDSIIRDLERENVGPEFGEFLNTLQTDLNSEKPPIEQVKSQLETHFNLAHETQEFSRKNDNAPVDKLLTNYYNNYEVNVLEFVLQMGFSRDLSIPLNVWFVLDMISQLSTSKQDLPLDYYLVLNNSQTGKYSDFVRYLIYEAVGAEIHCFEQGSMPEQYRSSRWEDKVKGPALANRGPIRGNVGAGDRKITFHLLCKKTARMILVGDDRETDFEMSDRSFVTLLLDYYQRVGTTKKIDLLLLTNNFDTNMNNKLQQLKILESLNMLKSNCYVLDYQITVDQVTANFNSYVEGIPAFRRHEIANFLKKRKTPKNADELIFKYVGRWNICYQKKFHQGNISIHQISGYLD
Function: Structural subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Not required for catalytic activity. Fine-tunes allosteric regulation of the ATP-PFK by ATP, fructose 2,6-bisphosphate and AMP. Sequence Mass (Da): 40796 Sequence Length: 351 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm
Q9FC99
MRIGVLTSGGDCPGLNAVIRSVVHRAVVDHGDEVIGFRDGWKGLLECDYLKLDLDAVGGILARGGTILGSSRVRPEHLRDGVERARGHVEELGLDAIIPIGGEGTLKAARLLSDNGLPIVGVPKTIDNDIAVTDVTFGFDTAVTVATEALDRLKTTAESHQRVLIVEVMGRHTGWIALHSGMAAGAHAVVVPERPFDIDELTAKVGERFSAGKRFAIVVAAEGAKPKAGTMDFDEGGKDVYGHERFAGIARQLSIELEERLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGEFGKMTALRGTDIEMVSLADAVESLKTVPDARYAEAECVL
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 36432 Sequence Length: 341 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm EC: 2.7.1.11
Q9FKG3
MEASISFLGSTKPNISLFNPSSNVLPRRDFPLPALKLKKVSVLPRILHQKRLIRAQCSDGFKPEEDDGFVLEDVPHLTKFLPDLPSYPNPLKESQAYAIVKRTFVSSEDVVAQNIVVQKGSKRGVHFRRAGPRERVYFRSDEVKACIVTCGGLCPGINTVIREIVCGLNNMYGVNNILGIQGGYRGFYSKNTMNLTPKVVNDIHKRGGTFLQTSRGGHDTAKIVDNIQDRGINQVYIIGGGGTQKGAEKIYEEVERRGLQVAVSGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGIVKLMGRYSGFIAMIATLANRDVDCCLIPESPFFLEGKGGLFEFIEERLKENRHMVIVIAEGAGQDYVAQSMRASETKDASGNRLLLDVGLWLTQQIKDHFTNVRKMMINMKYIDPTYMIRAIPSNASDNVYCTLLAQSAVHGAMAGYSGFTVGPVNSRHAYIPISQVTEVTNTVKLTDRMWARLLASTNQPSFLTGEGALQNVIDMETQEKIDNMKISSI
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 58467 Sequence Length: 530 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Plastid EC: 2.7.1.11
Q8VYN6
MDALSQAISSGISVPYKNNSSSLVPSHGLTSLILRKSRSPVNPSSRSRVSVRASEIQHSKTSASSIDLSDPDWKLKYEKDFEQRFSIPHITDVLPDAEAIRSTFCLKMRSPTEDFVGGYPSDEEWHGYINNNDRVLLKVISYSSPTSAGAECLDHDCSWVEQWIHRAGPREKIYFRPEEVKAAIITCGGLCPGLNDVIRHIVITLEIYGVKNIVGIPFGYRGFSDKDLTEMPLSRKVVQNIHLSGGSLLGVSRGGPSVSEIVDSMEERGINMLFVLGGNGTHAGANAIHNECRKRKIKVAVVGVPKTIDNDILHMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGVVKLMGRNSGFIAMQASLASGQVDICLIPEVPFNLHGPNGVLKHLKYLIETKGSAVICVAEGAGQNFLEKTNAKDASGNAVLGDFGVYIQQETKKYFKEISTPIDVKYIDPTYMIRAVRANASDGILCTVLGQNAVHGAFAGYSGITVGIINTHYAYLPITEVIAYPKSVDPNSRMWHRCLTSTGQPDFI
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 58615 Sequence Length: 537 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Plastid EC: 2.7.1.11
Q9M076
MASNGVDEQIKLVEGPAGYVLEDVPHLSDYILDLPTYPNPLQSNAAYSVVRQYFVDEDDTVQEKIVVHKDSPRGTHFRRAGPRQKVYFKPSDVRACIVTCGGLCPGLNTVIREIVCGLHFMYGVTEVIGVDCGFRGFYSKNTVALTPKTVSDIHKRGGTILGTSRGGHDTSKIVDNIQDREINQVYIIGGDGTQKGANAIYKEIRRRGLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEATSVENGIGIVKLMGRYSGFIAMYATLASRDVDCCLIPESPFYLEGKGGLYEFIAKRLRENGHMVIVIAEGAGQDLVAESIEQQDASGNKLLKDVGLWMSLKIKEYFAKHNVMDITLKYIDPTYMIRAIPANASDNVYSTLLAQSAVHGAMAGYTGFVSGLVNGRHTYIPFNRITERQNKVVITDRMWARMLSSTNQPSFMNPPKGTTEFTD
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 50788 Sequence Length: 462 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm EC: 2.7.1.11
P17858
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis . Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). PTM: GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 85018 Sequence Length: 780 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm EC: 2.7.1.11
P30835
MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAAYNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLSIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSSVTELKKETDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). PTM: GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation (By similarity). Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 85339 Sequence Length: 780 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm EC: 2.7.1.11
P08237
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. PTM: GlcNAcylation decreases enzyme activity. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 85183 Sequence Length: 780 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. Subcellular Location: Cytoplasm EC: 2.7.1.11
P06999
MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 32456 Sequence Length: 309 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. EC: 2.7.1.11
P9WID2
MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRYDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Can also catalyze the phosphorylation of tagatose-6-phosphate. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 35401 Sequence Length: 339 Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. EC: 2.7.1.11
D9TT10
MFNFNDKIVFDDKKYDVLTVGEMLVDMISTDYGDDFECDTYKKYFGGSPANIAINSKMLGINSIIVSSVGNDGLGKFLLKKLQEHHIEIKYVRQVDYSTSMVLVTKSKSSPTPIFYRDADYHIEYSDELKYLIENTKIVHFSSWPISRNPSRSTVEILIDECKKYDVLVCYDPNYHSMIWERGHDGREYIKSLIAKVDIIKPSEDDAERIFGKDTPENQLKKFLDLGAKLVILTLGKDGAIVSNGEETIRFNTLADEVVDTTGAGDAFWSGFYSGLIKGYTLKKSLELGFAVSAYKLRYVGAIVDLPDIDTIKSMYDLKKLR
Function: Catalyzes the ATP-dependent phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate. Together with the adjacently encoded sucrose 6'-phosphate phosphorylase, may be involved in a new pathway for the degradation of sucrose. Cannot phosphorylate D-fructose. Catalytic Activity: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 36535 Sequence Length: 322 EC: 2.7.1.11
Q4A724
MENKFARTVLGDIPVEKLGITDCHDHFIKNGGPEVEEHIDFLMLNVDASIKEFKEFIDRGGSTIVTMDPPNVGRDVLKTLEIANAVKNLGGNVIMSTGFHKAKFYDKYSSWLAVVPTEEIVKMCVAEIEEGMDEYNYNGPVVKRSKAKAGIIKAGTGYGAIDRLELKALEVAARTSILTGCPILVHTQLGTMALEVAKHLIGFGANPDKIQISHLNKNPDKYYYEKVIKETGVTLCFDGPDRVKYYPDSLLAENIKYLVDKGLQKHITLSLDAGRILYQRNYGLTKGKQTFGLAYLFDRFLPLLKQVGVSKEAIFDILVNNPKRVLAFDEKRNFDPLKVSKEVLELKKELNLN
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Catalyzes the hydrolysis of D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Also able to hydrolyze carboxy 1,4-lactones. Catalytic Activity: a 1,4-lactone + H2O = a 4-hydroxyacid + H(+) Sequence Mass (Da): 39499 Sequence Length: 353 EC: 3.1.1.104
Q46267
MVMGRIHSIESMGLVDGPGIRTVVFFQGCGLRCSYCHNPDTWNMAGGKELTAEELLKKLLRFKPYFDRSGGGVTFSGGEVLLQPEFLIDILKLCKEQGIHTAIDTAGYGYGNYEEILKHTDLVLLDIKHVDDDGYKCITGKGKRGFDDFLKAVENIGVKVWIRHVIVPTLTDSKENIRKLANIIKNIRNVEKVELLPYHTLGINKYEKLNLDYKLRDIEAMDKEKRKKLEKYLKELLE
Cofactor: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Function: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. Catalytic Activity: glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] Sequence Mass (Da): 27148 Sequence Length: 238 Subcellular Location: Cytoplasm EC: 1.97.1.4
P9WIG3
MSFVIAAPEVIAAAATDLASLGSSISAANAAAAANTTALMAAGADEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAAVSPLLDPINEFFLANTGRPLIGNGANGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAGGNGGAGGLIGNGGAGGAGGVASSGIGGSGGAGGNAMLFGAGGAGGAGGGVVALTGGAGGAGGAGGNAGLLFGAAGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSGGAGGAGGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGGLFGAGGEGGSGGHSLVAGGDGGAGGNAGMLALGAAGGAGGIGGDGGTLTAGGIGGAGGAGGNAGLLFGSGGSGGAGGFGFADGGQGGPGGNAGTVFGSGGAGGNGGVGQGFAGGIGGAGGTPGLIGNGGNGGNGGASAVTGGNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGVSGLLLGLDGFNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGANGTPGTGAAGGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGAGGAGGVSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPAGVGGAGGNGGLFANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGAGGTGGAAGSGGSGITTGGGGHGGNAGLLSLGASGGAGGSGGASSLAGGAGGTGGNGALLFGFRGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGANALGAGTGGTGGDGGHAGVFGNGGDGGCRRVWRRYRRQRWCRRQRRADRQRRQRRQRRQSRGHARCRRHRRAAARRERTQRLAIAGRPATTRGVEGISCSPQMMP
Function: The arginine-rich C-terminal region protrudes from the mycobacterial membrane and mediates M.tuberculosis entry into host epithelial cells . May serve as a bridge between mycobacteria and host cells by interacting with specific host phospholipids and extracting them from host cells, for their direct integration or as a source of phosphate, during phases of TB pathogenesis when M.tuberculosis is short of phosphate supply . PTM: A cleavage of the protein removes the N-terminal 120-150 residues, immediately upstream the PGRS domain . The exact position of the cleavage site could not be identified . Sequence Mass (Da): 81904 Sequence Length: 957 Domain: The 77 amino acids long, arginine-rich C-terminal domain plays a critical role in tuberculosis pathogenesis . This positively charged helical domain specifically binds phosphorylated phosphatidylinositols and cardiolipin, whereas it is unable to bind other phospholipids . Subcellular Location: Cell outer membrane
P18384
MIALLILSLTCSVSTYRLQGFTNAGIVAYKNIQDDNIVFSPFGYSFSMFMSLLPASGNTRIELLKTMDLRKRDLGPAFTELISGLAKLKTSKYTYTDLTYQSFVDNTVCIKPSYYQQYHRFGLYRLNFRRDAVNKINSIVERRSGMSNVVDSNMLDNNTLWAIINTIYFKGIWQYPFDITKTRNASFTNKYGTKTVPMMNVVTKLQGNTITIDDEEYDMVRLPYKDANISMYLAIGDNMTHFTDSITAAKLDYWSFQLGNKVYNLKLPKFSIENKRDIKSIAEMMAPSMFNPDNASFKHMTRDPLYIYKMFQNAKIDVDEQGTVAEASTIMVATARSSPEKLEFNTPFVFIIRHDITGFILFMGKVESP
Function: Negatively regulates superinfection and syncytium formation in infected host cells. Acts in concert with OPG185/A56 protein at the host cell membrane by interacting with and inhibiting the mature virion entry/fusion complex (EFC). This mechanism ensures that new virions released from the cell cannot enter already infected cells. Location Topology: Peripheral membrane protein Sequence Mass (Da): 42286 Sequence Length: 369 Subcellular Location: Virion membrane
P21030
MGGGVSVELPKRDPPPGVPTDEMLLNVDKMHDVIAPAKLLEYVHIGPLAKDKEDKVKKRYPEFRLVNTGPGGLSALLRQSYNGTAPNCCRTFNRTHYWKKDGKISDKYEEGAVLESCWPDVHDTGKCDVDLFDWCQGDTFDRNICHQWIGSAFNRSNRTVEGQQSLINLYNKMQTLCSKDASVPICESFLHHLRAHNTEDSKEMIDYILRQQSADFKQKYMRCSYPTRDKLEESLKYAEPRECWDPECSNANVNFLLTRNYNNLGLCNIVRCNTSVNNLQMDKTSSLRLSCGLSNSDRFSTVPVNRAKVVQHNIKHSFDLKLHLISLLSLLVIWILIVAI
Function: Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation. PTM: Unglycosylated because produced in viral factories instead of the classic ER -Golgi route. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 38786 Sequence Length: 340 Subcellular Location: Virion membrane
P15910
MGAAASIQTTVTTINKKISEKLEQTASASATANCDINIGNIIFKKNKGCNVLVKNMCSANASAQLDAIVSAVREVYDQLTEQQKAYAPSLLTAALNIQTNVSTITQDFETYIKQKCNSDAVINNIINVQSLEVDECSAPPGQIMTFEFINTGTATGNCAMKSVLDVLTKSSDRVSGNQSTGNDFSKYLYIIGGIICFLILLYYAKKLFFMSTNDKVKVLLAKKPDVHWTTYIDTYFRSSPVLV
Function: Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation. PTM: Myristoylated. Location Topology: Single-pass membrane protein Sequence Mass (Da): 26519 Sequence Length: 243 Subcellular Location: Virion membrane
P07612
MGAAASIQTTVNTLSERISSKLEQEANASAQTKCDIEIGNFYIRQNHGCNLTVKNMCSADADAQLDAVLSAATETYSGLTPEQKAYVPAMFTAALNIQTSVNTVVRDFENYVKQTCNSSAVVDNKLKIQNVIIDECYGAPGSPTNLEFINTGSSKGNCAIKALMQLTTKATTQIAPKQVAGTGVQFYMIVIGVIILAALFMYYAKRMLFTSTNDKIKLILANKENVHWTTYMDTFFRTSPMVIATTDMQN
Function: Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation. PTM: Myristoylated. Location Topology: Single-pass membrane protein Sequence Mass (Da): 27279 Sequence Length: 250 Subcellular Location: Virion membrane
P0DSR7
MITLFLILCYFILIFNIIVPAISEKMRRERAAYVNYKRLNKNFICVDDRLFSYNFTTSGIKAKVAVDNKNVPIPCSEINEVNNNKDVDTLYCDKDRDDIPGFTRSCYRAYSDLFFTT
Function: Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation). PTM: Contains two intramolecular disulfide bonds. They are created by the viral disulfide bond formation pathway, a poxvirus-specific pathway that operates on the cytoplasmic side of the MV membranes. Location Topology: Single-pass type III membrane protein Sequence Mass (Da): 13676 Sequence Length: 117 Subcellular Location: Virion membrane
Q5AF39
MQFSSAIILSAVAGSALATYANSTVTDIATTVVTITSCEENKCHETEVTTGVTTVTEVETTYTTYCPLPTAKAPVASTSNSTTTPPVSTAEGAAAANAVPAVAAGLLALGAFM
Function: Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation. PTM: N- and O-glycosylated. Location Topology: Lipid-anchor Sequence Mass (Da): 11249 Sequence Length: 113 Subcellular Location: Secreted
Q59VW6
MTTLSTIWLFLITITAIFQLGLSSNVTTIIDDDNNNNNNNNNNADDFLEPQIETIKVIGNKFFECESGHQFFIKGIAYQKTRQEGEIYDTTKEPHYIDPLANPFTCLRDLDYLKELGINLVRVYQIHPNANHDVCMNAFAEAGIYVLADLSEPTISIRRDYPHWDTEIFNRYQQVIDSMSNYKNLLGFFAGNEVTNCQSNIDASPFVRAAIRDCKKYINQQGYRKIPIGYASNDDANIRKNLANYFVCQLDEDEDKGQEHLNSQADFFAINVYEWCGYSTYTTSGYRDLTTMFKDYSVPVFFSEFGCNIITPRPFTEVEAIYGSTMKKVWSGGIAYEYFEEVNHYGILLTKKDGSITKLPDFDTLKMRFHAATPIGITMDEATICEPPICSNSVIDDKSSSSSSSSSFWDVALTLPPTPNEAKCECLWQSLSCVVSEDATFDEEVALRELCFKVDCEDINANGRSGKYGRYSDCNPTVRTSYALNKYYEQCGKKQEICDFQGRGELLPNRNGGLQDLENKFSSDGQNCLSLLEGKEEEKEVQEEEPDVPGLPGSNKGKEVESTPKRKGKGKSKEKEKGKLIEEEEEEEEEEEENNKTPSSGEKSPKTSKSIAGGNAITFKNDSIWKTFIEILFTCSAAILI
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 72378 Sequence Length: 641 Subcellular Location: Cell membrane EC: 2.4.1.-
Q5A8I6
MKSGLLLAVILPVAFAVKKDQQSCNSSCVKVLQKQQESCPSGSDADCLCKLSDSDYWEPLTDCDCINPDKKLSASEIKVQICGAPSSSSTPTSSTETTSSTEAETTEAETTEQPSSSTSSNTESSKTTILETPSIQELNAESTTSVITPLTESAVAAVANTDTSTLIEPQNTEATPEVAPLIQPQLNNGSDLAQVSVQAFENGAGRAAVIGSGSLLALLLNFI
Function: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 23182 Sequence Length: 223 Subcellular Location: Secreted
Q5AF41
MQFSSAVVLSAVAGSALAAYSNSTVTDIQTTVVTITSCEENKCHETEVTTGVTTVTEVDTTYTTYCPLSTTEAPAPSTATDVSTTVVTITSCEEDKCHETAVTTGVTTVTEGTTIYTTYCPLPSTEAPGPAPSTAEESKPAESSPVPTTAAESSPAKTTAAESSPAQETTPKTVAAESSSAETTAPAVSTAEAGAAANAVPVAAGLLALAALF
Function: Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation. PTM: N- and O-glycosylated. Location Topology: Lipid-anchor Sequence Mass (Da): 21255 Sequence Length: 213 Subcellular Location: Secreted
Q5APJ9
MQFQTLLVVAGSLVASTLAVNSTVTEHHTTEITITHCSDNKCATSVAPAVQSVNTVTIEGVVTEYTTYCPLTASEHKHKESSSPSSVAPVASTESVVTTTISGVHTSYTTYCPLSGSSEASTVITPGTVAGESSSSSEEVSYVDVTSTPVVESTTDVELTLTAQSTLFTSYANSTGSSSSSSVVPSANVTTFEGGAVGGASNQITVGFAAIAGLAAILL
Function: Probable cell wall protein that participates directly in adhesive cell-cell interactions. PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 22101 Sequence Length: 219 Subcellular Location: Secreted
Q59UT5
MHFIFYLILLVSAADYGNFGTYPKVPKTASINGFADPIYDLLPDCAKECVKFSTSNTPCPYWDTGCFCVMPQWAGLVGQCVAQKCKGEDVASARFLATSLCSVVGANTWMMPASISSMLSTAAGDAKEVTTIEGKTAKSWVTAPGSAAGSVVSETGSASETGSSESAQSTTTGSSSTGSSSTDSSSSSSSSPSSSANFAVLQTGGIGSVILGFMMYLLV
Function: GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization . Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade . The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation . PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Location Topology: Lipid-anchor Sequence Mass (Da): 22420 Sequence Length: 219 Domain: The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens . The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity). Subcellular Location: Secreted
P69435
MYSSSRKRCPKTKWALKLLTAAFLAASPAAKSAVNNAYDALIIEARKGNTQPALSWFALKSALSNNQIADWLQIALWAGQDKQVITVYNRYRHQQLPARGYAAVAVAYRNLQQWQNSLTLWQKALSLEPQNKDYQRGQILTLADAGHYDTALVKLKQLNSGAPDKANLLAEAYIYKLAGRHQDELRAMTESLPENASTQQYPTEYVQALRNNQLAAAIDDANLTPDIRADIHAELVRLSFMPTRSESERYAIADRALAQYAALEILWHDNPDRTAQYQRIQVDHLGALLTRDRYKDVISHYQRLKKTGQIIPPWGQYWVASAYLKDHQPKKAQSIMTELFYHKETIAPDLSDEELADLFYSHLESENYPGALTVTQHTINTSPPFLRLMGTPTSIPNDTWLQGHSFLSTVAKYSNDLPQAEMTARELAYNAPGNQGLRIDYASVLQARGWPRAAENELKKAEVIEPRNINLEVEQAWTALTLQEWQQAAVLTHDVVEREPQDPGVVRLKRAVDVHNLAELRIAGSTGIDAEGPDSGKHDVDLTTIVYSPPLKDNWRGFAGFGYADGQFSEGKGIVRDWLAGVEWRSRNIWLEAEYAERVFNHEHKPGARLSGWYDFNDNWRIGSQLERLSHRVPLRAMKNGVTGNSAQAYVRWYQNERRKYGVSWAFTDFSDSNQRHEVSLEGQERIWSSPYLIVDFLPSLYYEQNTEHDTPYYNPIKTFDIVPAFEASHLLWRSYENSWEQIFSAGVGASWQKHYGTDVVTQLGYGQRISWNDVIDAGATLRWEKRPYDGDREHNLYVEFDMTFRF
Function: Exports the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N-deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 92207 Sequence Length: 807 Domain: Contains a predicted C-terminal beta-barrel porin domain and a N-terminal periplasmic superhelical domain containing tetratricopeptide repeats, which may mediate protein-protein interactions, perhaps with PgaB. Subcellular Location: Cell outer membrane
P75906
MLRNGNKYLLMLVSIIMLTACISQSRTSFIPPQDRESLLAEQPWPHNGFVAISWHNVEDEAADQRFMSVRTSALREQFAWLRENGYQPVSIAQIREAHRGGKPLPEKAVVLTFDDGYQSFYTRVFPILQAFQWPAVWAPVGSWVDTPADKQVKFGDELVDREYFATWQQVREVARSRLVELASHTWNSHYGIQANATGSLLPVYVNRAYFTDHARYETAAEYRERIRLDAVKMTEYLRTKVEVNPHVFVWPYGEANGIAIEELKKLGYDMFFTLESGLANASQLDSIPRVLIANNPSLKEFAQQIITVQEKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWYPKND
Function: Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin. Location Topology: Lipid-anchor Sequence Mass (Da): 77413 Sequence Length: 672 Domain: Contains a N-terminal polysaccharide deacetylase domain, and a C-terminal domain required for PGA N-deacetylation that may be involved in binding to unmodified poly-beta-1,6-GlcNAc and thereby assists catalysis by the deacetylase domain. Subcellular Location: Cell outer membrane EC: 3.5.1.-
P75905
MINRIVSFFILCLVLCIPLCVAYFHSGELMMRFVFFWPFFMSIMWIVGGVYFWVYRERHWPWGENAPAPQLKDNPSISIIIPCFNEEKNVEETIHAALAQRYENIEVIAVNDGSTDKTRAILDRMAAQIPHLRVIHLAQNQGKAIALKTGAAAAKSEYLVCIDGDALLDRDAAAYIVEPMLYNPRVGAVTGNPRIRTRSTLVGKIQVGEYSSIIGLIKRTQRIYGNVFTVSGVIAAFRRSALAEVGYWSDDMITEDIDISWKLQLNQWTIFYEPRALCWILMPETLKGLWKQRLRWAQGGAEVFLKNMTRLWRKENFRMWPLFFEYCLTTIWAFTCLVGFIIYAVQLAGVPLNIELTHIAATHTAGILLCTLCLLQFIVSLMIENRYEHNLTSSLFWIIWFPVIFWMLSLATTLVSFTRVMLMPKKQRARWVSPDRGILRG
Function: Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homomer poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 50766 Sequence Length: 441 Subcellular Location: Cell inner membrane EC: 2.4.1.-
P69433
MNNLIITTRQSPVRLLVDYVATTILWTLFALFIFLFAMDLLTGYYWQSEARSRLQFYFLLAVANAVVLIVWALYNKLRFQKQQHHAAYQYTPQEYAESLAIPDELYQQLQKSHRMSVHFTSQGQIKMVVSEKALVRA
Function: Required for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase PgaC in the polymerization of PGA (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 16082 Sequence Length: 137 Subcellular Location: Cell inner membrane
P91268
MRASTACLVALLAPFYISALPVEYFYGDEQQPIEEGAENSAVFEQDRELIGLFNPSKEIGQVSGLAVNKNGHIVAFHRSGRVWDEKSFNDHETFNKDLGVINNKTIAIISREKKVIDEFGAGLFYMPHGLTIDNNGDYWVTDVGSHQVHKIDAKTQKIVMSLGEKMVPGEDQAHFCKPTDVAVAKNGHIFVADGYCNSRILKFDAKGNLMAQINAATEENQPSEFVVPHSLSLIEDMNIVCVADRENQRVQCFSAGLSEGDRTLPTGIPITSATDIGRVFAIREREHYLIGVTGNSEDVEAQMFSIDMQTGKTETFAKGVRNTHALAIAADGVMFVSQLEPSRILEIRLL
Function: Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity). Catalytic Activity: a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate Sequence Mass (Da): 38593 Sequence Length: 350 Subcellular Location: Secreted EC: 4.3.2.5
P18669
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate . Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate . PTM: Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 28804 Sequence Length: 254 EC: 5.4.2.11
P08966
MSLAPKKTIDDAVVKGKKVLIRVDFNVPVKNGEITNDFRIRSALPTIQKVLKEGGSCILMSHLGRPKGAKMSDPKPAKSVRGYEEAATLRPVAARLSELLGQKVEFAPDCLDAASYAAKLKGGDVLLLENVRFYAEEGSKKEEERDAMAKVLAAYGDVYVSDAFGTAHRDSADMTGIPKVLGAGYAGYLMEKEINYFAQVLNNPPRPLVAIVGGAKVSDKIQLLDNMLGRINYLVIGGAMAYTFQKAQGHAIGISMCEEDKLDLAKSLLKKAQERNVEVLLPVDHVCNKEFQGVDAPLVTKDVEIPEGYMALDIGPKTIKIYEDVIAKCKSTIWNGPMGVFEMPCYSKGTFAVAKAMGNGTQKNGLMSIIGGGDTASAAELSGEAKNMSHVSTGGGASLELLEGKSLPGVTVLTNKE
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 44603 Sequence Length: 417 Domain: This cytosolic PGK lacks a C-terminal extension of 38 AA which is present in the glycosomal isoenzyme. Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
P08967
MSLVPKKSIDDAVVKGKKVLIRVDFNVPVKNGEITNDFRIRSALPTIQKVLKEGGSCILMSHLGRPKGAKMSDPKPAKSVRGYEEAATLRPVAARLSELLGQKVEFAPDCLDAASYAAKLKGGDVLLLENVRFYAEEGSKKEEERDAMAKVLAAYGDVYVSDAFGTAHRDSADMTGIPKVLGAGYAGYLMEKEINYFAQVLNNPPRPLVAIVGGAKVSDKIQLLDNMLGRINYLVIGGAMAYTFQKAQGHAIGISMCEEDKLDLAKSLLKKAQERNVEVLLPVDHVCNKEFQGVDAPLVTKDVEIPEGYMALDIGPKTIKIYEDVIAKCKSTIWNGPMGVFEMPCYSKGTFAVAKAMGNGTQKNGLMSIIGGGDTASAAELSGEAKNMSHVSTGGGASLELLEGKSLPGVTVLTNKDAKAPAAAAAAGGDCPCGSGCAAVPAAATATVSMVLASP
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 47843 Sequence Length: 455 Domain: This glycosomal PGK has a C-terminal extension of 38 AA which is not present in the cytosolic isoenzyme. This domain most likely serves as topogenic signal to direct the glycosomal PKG to the glycosome. Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Glycosome EC: 2.7.2.3
P07378
MTLNEKKSINECDLKGKKVLIRVDFNVPVKNGKITNDYRIRSALPTLKKVLTEGGSCVLMSHLGRPKGIPMAQAGKIRSTGGVPGFQQKATLKPVAKALSELLLRPVTFAPDCLNAADVVSKMSPGDVVLLENVRFYKEEGSKKAKDREAMAKILASYGDVYISDAFGTAHRDSATMTGIPKILGNGAAGYLMEKEISYFAKVLGNPPRPLVAIVGGAKVSDKIQLLDNMLQRIDYLLIGGAMAYTFLKAQGYSIGKSKCEESKLEFARSLLKKAEDRKVQVILPIDHVCHTEFKAVDSPLITEDQNIPEGHMALDIGPKTIEKYVQTIGKCKSAIWNGPMGVFEMVPYSKGTFAIAKAMGRGTHEHGLMSIIGGGDSASAAELSGEAKRMSHVSTGGGASLELLEGKTLPGVTVLDEKSAVVSYASAGTGTLSNRWSSL
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 47119 Sequence Length: 440 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Glycosome EC: 2.7.2.3
Q9LD57
MASAAASSAFSLLKSTGAVASSAGTRARASLLPIPSTSVSARPLGFSATLDSRRFSLHVASKVESVRGKGSRGVVSMAKKSVGDLTSADLKGKKVFVRADLNVPLDDNQTITDDTRIRAAIPTIKYLIENGAKVILSTHLGRPKGVTPKFSLAPLVPRLSELLGIEVTKADDCIGPEVESLVASLPEGGVLLLENVRFYKEEEKNDPEFAKKLASLADLYVNDAFGTAHRAHASTEGVTKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLGGGMIFTFYKAQGLSVGSSLVEEDKLELATELLAKAKAKGVSLLLPTDVVVADKFAPDANSKIVPASGIEDGWMGLDIGPDSIKTFNEALDTTQTVIWNGPMGVFEMEKFAAGTEAIANKLAELSEKGVTTIIGGGDSVAAVEKVGVAGVMSHISTGGGASLELLEGKVLPGVIALDEAIPVTV
Function: May trigger the phosphorylation of FTSZ2-1 and FTSZ2-2. Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 50112 Sequence Length: 481 Pathway: Carbohydrate biosynthesis; Calvin cycle. Subcellular Location: Plastid EC: 2.7.2.3
P80659
ALTEQASKVALTADL
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 1531 Sequence Length: 15 Pathway: Carbohydrate biosynthesis; Calvin cycle. Subcellular Location: Plastid EC: 2.7.2.3
P36232
AKKSVGDLTKADLEGKRVFVRADLNVPLDKEQKXTD
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 3997 Sequence Length: 36 Pathway: Carbohydrate biosynthesis; Calvin cycle. Subcellular Location: Plastid EC: 2.7.2.3
Q9SBN4
MALSMKMRANARVVSGRRVAAVAPRVVPFSSVARPVLRSTFAPEVSIDIRRAGRSRIVVEAVKKSVGDLGKADLEGKRVFVRADLNVPLDKKTLAITDDTRIRAAVPTLKYLLDNGAKVLLTSHLGRPKGGPEDKYRLTPVVARLSELLGKEVKKVDDCIGPSVEQAVASLKSGELLLLENVRFYKEEEKNDPEFAKKLASNADLYVNDAFGTAHRAHASTEGVTKFLKPSVAGFLLQKELDYLDGAVSAPKRPFVAIVGGSKVSSKITVIEKLMEKCDKIIIGGGMIFTFYKARGLKVGSSLVEEDKLELAKNLEAIAKAKGVQLLLPSDVVVADKFDANANTQTVSVEAIPDGWMGLDIGPDSIKTFQDALADAKTVVWNGPMGVFEFPKFAVGTVAIANTLSELTPKGAITIIGGGDSVAAVEQAGVAEKMSHISTGGGASLELLEGKVLPGVAALDEK
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 49141 Sequence Length: 462 Pathway: Carbohydrate biosynthesis; Calvin cycle. Subcellular Location: Plastid EC: 2.7.2.3
P83075
MNKKSIRNVNLKGKRVFDRV
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 2403 Sequence Length: 20 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
Q8A753
MQTIDKFNFAGKKAFVRVDFNVPLDENFNITDDTRMRAALPTLKKILADGGSIIIGSHLGRPKGVADKFSLKHIIKHLSELLGVEVQFANDCMGEEAAVKAAALQPGEVLLLENLRFYAEEEGKPRGLAEDATDEEKAAAKKAVKESQKEFTKKLASYADCYVNDAFGTAHRAHASTALIAKYFDTDNKMFGYLMEKEVKAVDKVLNDIQRPFTAIMGGSKVSSKIEIIENLLNKVDNLIIAGGMTYTFTKAMGGKIGISICEDDKLDLALDLIKKAKEKGVNLVLAVDAKIADAFSNDANTQFCAVDEIPDGWEGLDIGPKTEEIFANVIKESKTILWNGPTGVFEFENFTHGSRTVGEAIVEATKNGAFSLVGGGDSVACVNKFGLASGVSYVSTGGGALLEAIEGKVLPGIAAINE
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 45026 Sequence Length: 419 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
B2KC44
MQLENIKKLQDLDVKGKTVLVRVDYNVPLKDGKVDNNKRIVASEKTVKYLLDNNCKVVLMSHLGRPKGKVASEFSLAPVATEVANVFGVKVHFASDCIGEPAAKTIAEAKNGEIVLLENLRFHPEEEKNDETFAAQLAKNGEVFVQEAFGTVHRAHASTSAVTKFLNGGIGYLVQKEVQFLGDALAKPNRPFAAIIGGAKVSDKIMVLNTLLSKVNVLVIGGGMAYTFLKAQGYTTGKSLLEEDKVEEANKILATAKEKGVEILLPVDHVCSTEFSNESPVMTTENANIPEGQMGLDIGPKTIALFDKKLLECKTIFWNGPVGVFEMSNFEKGSFAIASSMVEATKLGATTIIGGGDSLNVLKKAKIKTDLLSHCSTGGGASMEFVEGKELPGLTALAK
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 42784 Sequence Length: 399 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
P11977
MSLTSKLSITDVDLKDKRVLIRVDFNVPLDKNDNTTITNPQRIVGALPTIKYAIDNGAKAVILMSHLGRPDGKKNPKYSLKPVVPKLKELLGRDVIFTEDCVGPEVEETVNKASGGQVILLENLRFHAEEEGSSKDADGNKVKADKDAVAQFRKGLTALGDIYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALEEPQRPFLAILGGSKVSDKIQLIDNLLPKVNSLIITGGMAFTFKKTLENVKIGSSLFDEAGSKIVGNIIEKAKKHNVKVVLPVDYVTADKFAADAKTGYATDEQGIPDGYMGLDVGEKSVESYKQTIAESKTILWNGPPGVFEMEPFAKATKATLDAAVAAVQNGATVIIGGGDTATVAAKYGAEDKISHVSTGGGASLELLEGKELPGVAALSEKSK
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 44909 Sequence Length: 421 Subcellular Location: Cytoplasm EC: 2.7.2.3
Q1AUH7
MDKRSVRDLELRGKKVLVRVDFNVPVKGGEVTDDTRIRRALPTIRYLLQRGARVALISHLGRPKGEPDPRYRMDPVARRLEELLGEPVRKLDTATGPEVGRALEELERGVILLENSRFYPGETKNDPAFAAELAGPFDLYVNDAFGAAHRAHATTVGVAERLPAAAGFLLEQELDYLDGVLRSPERPFVAILGGAKVSDKLGVIESLLGVADRLLVGGAMCFTFLKARGLGVGASLVEDDYLGEARRLMEGAADRLVLPVDVVVAERMEEGARTRTVPVEEIPEGWMGLDIGPRTVELFRRHILQARTIFWNGPMGVFEIDAFARGTEGVARAVAESGATSVVGGGDSVAAVRKLGLEDRMSHISTGGGASLEYVEGRELPGVAVLPEREEV
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 42491 Sequence Length: 392 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
A4FBM5
MKNLDDLLSEGVRGRRVLVRADLNVPLDGDRITDDGRVRASLPTIEKLTGAGARVVVTAHLGRPKGEPDPKFSLAPVAARLGELLGADVALAGDVVGESAKSAVAAQADGSVVLLENVRFDARETSKDDAERGALADELAALVGDGAAFVSDGFGVVHRKQASVYDIAKRVPGYAGGLVLSEVEVLRTLTGDPRRPYAVVLGGSKVSDKLGVIQALLPKVDKLLIGGGMAYTFLAAQGHSVGKSLLQQDQVESTCKLLEEHGDKLVLPVDVVVADRFAADAESRVVDADAIPADWMGLDIGPRSVELFAGILAGSRTVFWNGPAGVFEFPAFAEGTRGIAQAIVDSGSFSVVGGGDSAAAVRSLGLPEDGFSHISTGGGASLEYLEGKELPGVSVLEEGR
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 41410 Sequence Length: 400 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
P50317
MGDLTIPTMDDIDIQSKKVLLRIDINSPVDENGKIIDDSRIKAHIGTIKELINKGNSVVLISHQGRPGDKDFTSLEEHAKLISKYLDREVIFVDDVIGPYAREMIKKLENNGILLLDNIRLISEELIEAPPQQHVKSFLVKKLAPLFDIYINDAFATAHRSQPSIVGFPLALPSAAGRVMEREVSALAKIFNAEDTPKIFTLGGGKVHDTIRIIENLVRKRIADRILTGGLVAELFSVAKGMNLNPKNMEILEKLGILSLIPRARKLLLSGAPIEIPVDYKVEINGNVIEEPASKVTGIIKDIGSTTAEIYSSFIKDAKVVVLRGPMGVIEDERFKSGSKSVLKASLEGQGYVIIGGGHMISALDEDMKIDSSKVHISTGGGALLLFLSGERLPALEALSMSVVNSGD
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 44396 Sequence Length: 408 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
P09404
MAFRTLDDIGDVKGKRVLVREDLNVPMDGDRVTDDTRLRAAIPTVNELAEKGAKVLILAHFGRPKGQPNPEMSLARIKDALAGVLGRPVHFINDIKGEAAAKAVDALNPGAVALLENTRFYAGEEKNDPALAAEVAKLGDFYVNDAFSAAHRAHVSTEGLAHKLPAFAGRAMQKELEALEAALGKPTHPVAAVVGGAKVSTKLDVLTNLVSKVDHLIIGGGMANTFLAAQGVDVGKSLCEHELKDTVKGIFAAAEKTGCKIHLPSDVVVAKEFKANPPIRTIPVSDVAADEMILDVGPKAVAALTEVLKASKTLVWNGPLGAFEIEPFDKATVALAKEAAALTKAGSLISVAGGGDTVAALNHAGVAKDFSFVSTAGGAFLEWMEGKELPGVKALEA
Catalytic Activity: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP Sequence Mass (Da): 41388 Sequence Length: 397 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Subcellular Location: Cytoplasm EC: 2.7.2.3
Q8H112
MGSKMLFSLTSPRLFSAVSRKPSSSFSPSPPSPSSRTQWTQLSPGKSISLRRRVFLLPAKATTEQSGPVGGDNVDSNVLPYCSINKAEKKTIGEMEQEFLQALQSFYYDGKAIMSNEEFDNLKEELMWEGSSVVMLSSDEQRFLEASMAYVSGNPILNDEEYDKLKLKLKIDGSDIVSEGPRCSLRSKKVYSDLAVDYFKMLLLNVPATVVALGLFFFLDDITGFEITYIMELPEPYSFIFTWFAAVPVIVYLALSITKLIIKDFLILKGPCPNCGTENTSFFGTILSISSGGKTNTVKCTNCGTAMVYDSGSRLITLPEGSQA
Function: Ferredoxin-plastoquinone reductase involved in cyclic electron flow (CEF) around photosystem I. The homodimer is probably not involved in CEF. PTM: Disulfide bonds; Cys-300 and Cys-303 are probably involved in the formation of disulfide bridges with 'Cys-11' and 'Cys-105' of PGR5 while Cys-272 and Cys-275 are probably involved in the binding of a Fe-containing cofactor (FCC). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 35721 Sequence Length: 324 Domain: The C-terminal loop (258-324) is required for ferredoxin binding. Subcellular Location: Plastid
P92990
MLKQFLLLQSFSFFLFNVVIVGGRTFGGGFSAEENPFTPKASLVRYWNKEIRGQSPRSEFLISKASPLNAVDSATFSKLAAANSLPTRFPDFCSAANLFCFPDLGASLEKHDDDVKFSVYDQKNFTNYGNARAGGADSFKNYSKDGNVVTDSFRRYSRNAAGHDDKFTVYGENSNVVEEGFNSYGTFGTGGAGDFTNYQNNVNNPTSRFTAYSDGGNGRSQTFKTYTHEANAGNGQSFTSYGKNGNGVPNEFTSYGVSSNVIGSGFSNYGESGNAANDTFTSYGSDGNVPQNNFNNYGASGNAAVDTFANYRDKANVGDDSFSSYAKDSNSEKVNFVNYGQSFNPGSETFTGYGKGAEGSKLSFKTYTPNSTFKDYAKKGVAFAKYNVSTTTANTVGDGKTVNKWIEPGKFFRESSLKEGTVIPMPDIKDKMPKRSFLPRSIITKLPFSTSKLGEIKRIFHAVENSTMGGIITDAVTECERPPSVGETKRCVGSAEDMIDFATSVLGRSVVLRTTENVAGSKEKVVIGKVNGINGGKLTKAVSCHQSLYPYLLYYCHSVPKVRVYEADLLELNSKKKINHGIAICHMDTSSWGPSHGAFLALGSKPGRIEVCHWIFENDMNWAIAD
Function: Involved in cell size determination. May serve as a chaperone for expansins through the secretory pathway. Sequence Mass (Da): 68060 Sequence Length: 626 Domain: The BURP domain located at the C-terminus has not been identified in non-plant proteins . It is critical for PGL3's role in cell growth . Subcellular Location: Secreted
G5EBV6
MEANKRQIVEVDGIKSYFFPHLAHYLASNDELLVNNIAQANKLAAFVLGATDKRPSNEEIAEMILPNDSSAYVLAAGMDVCLILGDDFRPKFDSGAEKLSQLGQAHDLAPIIDDEKKISMLARKTKLKKSNDAKILQVLLKVLGAEEAEEKFVELSELSSALDLDFDVYVLAKLLGFASEELQEEIEIIRDNVTDAFEACKPLLKKLMIEGPKIDSVDPFTQLLLTPQEESIEKAVSHIVARFEEASAVEDDESLVLKSQLGYQLIFLVVRSLADGKRDASRTIQSLMPSSVRAEVFPGLQRSVFKSAVFLASHIIQVFLGSMKSFEDWAFVGLAEDLESTWRRRAIAELLKKFRISVLEQCFSQPIPLLPQSELNNETVIENVNNALQFALWITEFYGSESEKKSLNQLQFLSPKSKNLLVDSFKKFAQGLDSKDHVNRIIESLEKSSSSEPSATAKQTTTSNGPTTVSTAAQVVTVEKMPFSRQTIPCEGTDLANVLNSAKIIGESVTVAAHDVIPEKLNAEKNDNTPSTASPVQFSSDGWDSPTKSVALPPKISTLEEEQEEDTTITKVSPQPQERTGTAWGSGDATPVPLATPVNEYKVSGFGAAPVASGFGQFASSNGTSGRGSYGGGRGGDRGGRGAYGGDRGRGGSGDGSRGYRGGDRGGRGSYGEGSRGYQGGRAGFFGGSRGGS
Function: Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate . P-granule component involved in germline development . Together with the P-granule component pgl-1, is involved in the formation of P-granules . Together with pgl-1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules . In vitro, binds mRNA; this interaction is required for the formation of liquid-like droplets that resemble P-granules . Most likely recruits pgl-1 into P-granules during autophagy . Associates with adapters such as sepa-1 and is required for the accumulation and degradation of P-granules by autophagy in somatic cells . This ensures exclusive localization of the P-granules in germ cells . In addition, may act redundantly with pgl-1 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms . This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis . May protect somatic cells from excessive apoptosis during normal development . PTM: Methylated at arginine residues in the RNA-binding RGG-box by prmt-1. Methylation promotes P-granule degradation by autophagy. Catalytic Activity: [RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment]. Sequence Mass (Da): 74845 Sequence Length: 693 Domain: The dimerization domain also acts as a hinge; changes in its structure probably impact oligomerization and RNA-binding. Subcellular Location: Cytoplasmic granule EC: 4.6.1.24
Q0P9C9
MRIGFLSHAGASIYHFRMPIIKALKDRKDEVFVIVPQDEYTQKLRDLGLKVIVYEFSRASLNPFVVLKNFFYLAKVLKNLNLDFIQSAAHKSNTFGILAAKWAKIPYRFALVEGLGSFYIDQGFKANLVRFVINSLYKLSFKFAHQFIFVNESNAEFMRNLGLKENKICVIKSVGINLKKFFPIYVESEKKELFWKNLNIDKKPIVLMIARALWHKGVKEFYESATMLKDKANFVLVGGRDENPSCASLEFLNSGAVHYLGARSDIVELLQNCDIFVLPSYKEGFPVSVLEAKACGKAIVVSDCEGCVEAISNAYDGLWAKTKNAKDLSEKISLLLEDEKLRLNLAKNAAQDALQYDENIIAQRYLKLYDRVIKNV
Function: Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N-linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide. Catalytic Activity: N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP Sequence Mass (Da): 42816 Sequence Length: 376 Pathway: Protein modification; protein glycosylation. EC: 2.4.1.290
B9KDD4
MKLQQNFTDNNSIKYTCILILIAFAFSVLCRLYWVAWASEFYEFFFNDQLMITTNDGYAFAEGARDMIAGFHQPNDLSYFGSSLSTLTYWLYSILPFSFESIILYMSAFFASLIVVPIILIAREYKLTTYGFIAALLGSIANSYYNRTMSGYYDTDMLVLVLPMLILLTFIRLTINKDIFTLLLSPVFIMIYLWWYPSSYSLNFAMIGLFGLYTLVFHRKEKIFYLTIALMIIALSMLAWQYKLALIVLLFAIFAFKEEKINFYMIWALIFISILILHLSGGLDPVLYQLKFYVFKASDVQNLKDAAFMYFNVNETIMEVNTIDPEVFMQRISSSVLVFILSFIGFILLCKDHKSMLLALPMLALGFMALRAGLRFTIYAVPVMALGFGYFLYAFFNFLEKKQIKLSLRNKNILLILIAFFSISPALMHIYYYKSSTVFTSYEASILNDLKNKAQREDYVVAWWDYGYPIRYYSDVKTLIDGGKHLGKDNFFSSFVLSKEQIPAANMARLSVEYTEKSFKENYPDVLKAMVKDYNKTSAKDFLESLNDKDFKFDTNKTRDVYIYMPYRMLRIMPVVAQFANTNPDNGEQEKSLFFSQANAIAQDKTTGSVMLDNGVEIINDFRALKVEGASIPLKAFVDIESITNGKFYYNEIDSKAQIYLLFLREYKSFVILDESLYNSSYIQMFLLNQYDQDLFEQITNDTRAKIYRLKR
Function: Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Catalytic Activity: tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine = tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 82729 Sequence Length: 712 Domain: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation. Pathway: Protein modification; protein glycosylation. Subcellular Location: Cell inner membrane EC: 2.4.99.19
Q0P9D0
MYEKVFKRIFDFILALVLLVLFSPVILITALLLKITQGSVIFTQNRPGLDEKIFKIYKFKTMSDERDEKGELLSDELRLKAFGKIVRSLSLDELLQLFNVLKGDMSFVGPRPLLVEYLPLYNKEQKLRHKVRPGITGWAQVNGRNAISWQKKFELDVYYVKNISFLLDLKIMFLTALKVLKRSGVSKEGHVTTEKFNGKN
Function: Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac). Catalytic Activity: tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP Location Topology: Single-pass membrane protein Sequence Mass (Da): 23144 Sequence Length: 200 Pathway: Protein modification; protein glycosylation. Subcellular Location: Membrane EC: 2.7.8.36
Q0P9D1
MARTEKIYIYGASGHGLVCEDVAKNMGYKECIFLDDFKGMKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIVNLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNCFLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAKRM
Function: Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway. Catalytic Activity: acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine Sequence Mass (Da): 21148 Sequence Length: 195 Pathway: Protein modification; protein glycosylation. EC: 2.3.1.203
Q0P9D3
MRFFLSPPHMGGNELKYIEEVFKSNYIAPLGEFVNRFEQSVKAYSKSENALALNSATAALHLALRVAGVKQDDIVLASSFTFIASVAPICYLKAKPVFIDCDETYNIDVDLLKLAIKECEKKPKALILTHLYGNAAKMDEIVEICKENEIVLIEDAAEALGSFYKNKALGTFGEFGAYSYNGNKIITTSGGGMLIGKNKEKIEKARFYSTQARENCLHYEHLDYGYNYRLSNVLGAIGVAQMEVLEQRVLKKREIYEWYKEFLGECFSFLDELENSRSNRWLSTALIDFDKNELNSCQKDINISQKNITLHPKISKLIEDLKNEQIETRPLWKAMHAQEVFKGAKAYLNGNSELFFQKGICLPSGTAMSKDDVYEISKLILKSIKA
Function: Aminotransferase involved in the bacillosamine biosynthesis pathway by producing UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose), a precursor used in the production of the glycan component 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose. Required for host colonization and virulence. Involved in the N-linked protein glycosylation pathway. Catalytic Activity: 2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose Sequence Mass (Da): 43654 Sequence Length: 386 Pathway: Protein modification; protein glycosylation. EC: 2.6.1.34
Q0P9D4
MIFYKSKRLAFFLTSDIVLILLSVYLAFSLRFSGDIPSIFYHGMMVSAIILLVLKLSFLFVFRIYKVAWRFFSLNEARKIFIALLLAEFCFFLIFYFFSDFFNPFPRSAIVIDFVLSYMFIGTLRISKRMLVDFKPSRMKEEETPCIVVGATSKALHLLKGAKEGSLGLFPVGVVDARKELIGTYCDKFIVEEKEKIKSYVEQGVKTAIIALRLEQEELKKLFEELVAYGICDVKIFSFTRNEARDISIEDLLARKPKDLDDSAVAAFLKDKVVLVSGAGGTIGSELCKQCIKFGAKHLIMVDHSEYNLYKINDDLNLYKEKITPILLSILDKQSLDEVLKTYKPELILHAAAYKHVPLCEQNPHSAVINNILGTKILCDSAKENKVAKFVMISTDKAVRPTNIMGCTKRVCELYTLSMSDENFEVACVRFGNVLGSSGSVIPKFKAQIANNEPLTLTHPDIVRYFMLVAEAVQLVLQAGAIAKGGELFVLDMGKPVKIIDLAKKMLLLSNRNDLEIKITGLRKGEKLYEELLIDENDAKTQYESIFVAKNEKVDLDWLNKEIENLQICEDISEALLKIVPEFKHNKEGV
Function: C6 dehydratase involved in the bacillosamine biosynthesis pathway by generating UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose from UDP-N-acetyl-alpha-D-glucosamine. Involved in the N-linked protein glycosylation pathway. Catalytic Activity: UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose Location Topology: Multi-pass membrane protein Sequence Mass (Da): 66766 Sequence Length: 590 Pathway: Protein modification; protein glycosylation. Subcellular Location: Membrane EC: 4.2.1.135
Q6KZ42
MFMTKDLFFVYIFTTMIKLVVLDVDGTLTDKSRMISVNAVNAIRNLKTKVALVSGNVLPVLYGLKIYIGFDGYIFAENGGIALINNNIEKFFEKDGPESFLNDISGYTSARGILTNRWRETSMAFTANHDEMDIIDREAASRDLYIVDSGFTLHILNKGQDKGFAVKKMIDIMNIDYNNVLVIGDSQNDESMFSLGTLSACPGNASEKIKEMSNYVSGKCYGDELFDVFRHFDLIH
Function: Catalyzes the dephosphorylation of 2-phosphoglycolate. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 26486 Sequence Length: 236 EC: 3.1.3.18
Q8ZT04
MACKVLVVDLDGTLTLGRNTYELSAEALLALRRARDAGIRVVLATANGLDFALTVARYLGIRDVIAENGCLVHLDGVTYELCSGDMAEVDRLVLSTGVVKPSHQNKCRKYDLAYIPLREDAVERLRDVLGPGYVVESSGYAIHVRPAGVDKGTAVKWLCQRLGVPCFQVASVGDSDVDVGMLSVSWGFAVGNATPAAKKAAKVVVDGPSGIGFKEAVEIILSGGACAP
Function: Catalyzes the dephosphorylation of 2-phosphoglycolate. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 24032 Sequence Length: 228 EC: 3.1.3.18
O50129
MKIKAISIDIDGTITYPNRMIHEKALEAIRRAESLGIPIMLVTGNTVQFAEAASILIGTSGPVVAEDGGAISYKKKRIFLASMDEEWILWNEIRKRFPNARTSYTMPDRRAGLVIMRETINVETVREIINELNLNLVAVDSGFAIHVKKPWINKGSGIEKASEFLGIKPKEVAHVGDGENDLDAFKVVGYKVAVAQAPKILKENADYVTKKEYGEGGAEAIYHILEKFGYL
Function: Catalyzes the dephosphorylation of 2-phosphoglycolate (By similarity). Has phosphatase activity towards p-nitrophenylphosphate (in vitro). Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 25606 Sequence Length: 231 EC: 3.1.3.18
A3DNN7
MIRLAAFDIDGTLTINRSSTVLCLEAIDALRKLEKNGVIVVLVSSNALPVVVGLKKYIGLSGPAIGETGALIYYGEEEIVATTKYSAKQAYLDVLEKYNEYVYGSWQNMFRLHDYALKIRKQYLSKDNEIYSLIKEYVENKYPYIKVGYSGYAIHLTPKDTGKGKALKQIMEKHGIRREETMGVGDSIMDWEFIKETKIKVAVANADPELRRKADIVTTKPSGYGVVEIVEKILDKPP
Function: Catalyzes the dephosphorylation of 2-phosphoglycolate. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 26765 Sequence Length: 238 EC: 3.1.3.18
Q96YM5
MVLSDFDRTLSDEKDNFIIKQEVVEVVNKFSAKFLFFVVTGRERKYMDILAKGLFPTGWIIENGGIIILRDKEIKLVDEKWYKIRKNLAKILDKNGIKYSLGEVIIYVNSAIDYKDKLDKINEAKIEWNRSDAMIMPKNVSKGEAVKILKSILNFEGVTIAIGDSQNDISLFSVADIKVAVANALPEIKAISDIVLDKEDGIGVMRFLEKILNDGSYLEKLIGFRK
Function: Catalyzes the dephosphorylation of 2-phosphoglycolate. Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 25654 Sequence Length: 226 EC: 3.1.3.18
Q9HLQ2
MIRLAAIDVDGTLTDRDRLISTKAIESIRSAEKKGLTVSLLSGNVIPVVYALKIFLGINGPVFGENGGIMFDNDGSIKKFFSNEGTNKFLEEMSKRTSMRSILTNRWREASTGFDIDPEDVDYVRKEAESRGFVIFYSGYSWHLMNRGEDKAFAVNKLKEMYSLEYDEILVIGDSNNDMPMFQLPVRKACPANATDNIKAVSDFVSDYSYGEEIGQIFKHFELM
Cofactor: Binds 5 Mg(2+) ions per homodimer. Function: Catalyzes the dephosphorylation of 2-phosphoglycolate. Also has significant, but less efficient, pyrophosphatase activity, since it is able to catalyze the release of phosphate from inorganic pyrophosphate (PPi). Catalytic Activity: 2-phosphoglycolate + H2O = glycolate + phosphate Sequence Mass (Da): 25279 Sequence Length: 224 EC: 3.1.3.18
Q9SL05
MAAASISAIGCNQTLIGTSFYGGWGSSISGEDYQTMLSKTVAPPQQARVSRKAIRAVPMMKNVNEGKGLFAPLVVVTRNLVGKKRFNQLRGKAIALHSQVITEFCKSIGADAKQRQGLIRLAKKNGERLGFLA
Function: Involved in the regulation of the cyclic electron flow (CEF) around Photosystem I. Essential for the reduction of PGRL1A by ferredoxin and for photoprotection. Contributes to maximize photosynthesis efficiency after a long dark adaptation via the regulation of non-photochemical quenching (NPQ) . PTM: Disulfide bonds; Cys-11 and Cys-105 are probably involved in the formation of disulfide bridges with 'Cys-300' and 'Cys-303' of PGRL1A. 'Cys-272' and 'Cys-275' of PGRL1A may also be used to form the disulfide bridges, but in this case the cyclic electron flow is lost. Location Topology: Peripheral membrane protein Sequence Mass (Da): 14293 Sequence Length: 133 Subcellular Location: Plastid
Q17QC0
MAAEDVAATGADTSELESGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQFTFKYHHVGKLLKDGEEPTVYSDKEEPKDESTRKND
Function: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Location Topology: Single-pass membrane protein Sequence Mass (Da): 21622 Sequence Length: 194 Domain: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 106 and 130. Subcellular Location: Microsome membrane
Q70PY2
MNTSTAISFVAALVLCCLALSANALQIEPRSSWGAVSARSPSRISGAVDYVIIHHSDNPNGCSTSEQCKRMIKNIQSDHKGRRNFSDIGYNFIVAGDGKVYEGRGFGLQGSHSPNYNRKSIGIVFIGNFERSAPSAQMLQNAKDLIELAKQRGYLKDNYTLFGHRQTKATSCPGDALYNEIKTWPHWRQN
Function: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN), preferentially DAP-type PGNs. Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 20998 Sequence Length: 190 Subcellular Location: Secreted EC: 3.5.1.28
Q9VV96
MKLQLALVLCGLTLALGQIVPRSSWCPVPISPRMPRLMVPVRLIIIHHTVTAPCFNPHQCQLVLRQIRADHMRRKFRDIGYNFLIGGDGRIYEGLGFGIRGEHAPRYNSQSIGIAFIGNFQTGLPPSQMLQAARTLIQIAVQRRQVSPNYSVVGHCQTKATACPGIHLLNELKKWPNWRPKP
Function: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity). Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 20459 Sequence Length: 182 Subcellular Location: Secreted EC: 3.5.1.28
Q9V4X2
MANKALILLAVLFCAQAVLGVTIISKSEWGGRSATSKTSLANYLSYAVIHHTAGNYCSTKAACITQLQNIQAYHMDSLGWADIGYNFLIGGDGNVYEGRGWNVMGAHATNWNSKSIGISFLGNYNTNTLTSAQITAAKGLLSDAVSRGQIVSGYILYGHRQVGSTECPGTNIWNEIRTWSNWKA
Function: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity). Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 19829 Sequence Length: 184 Subcellular Location: Secreted EC: 3.5.1.28
Q8W405
MVSSKQTQLKKGKQPSWIEMYLPKEVRPYAHLARLDKPIGSWLLAWPAFWSVALAADLESLPKMLAIFGWWAVWIRGAGCTINDYFDRNFDKKVERTKSRPLASGAVSPAQGLWWLAFQLFIGLGVLYQFNVLTLALAIVHVPFVFAYPLMKRITYWPQAFLGVMISWGALLGSSALKGSVVPSIAYPLYISSFFWTLVYDTIYAHQDKVDDAKAGIKSTALRFGDATKMWISWFGVGCIAALVIGGLILNIGLPYYVFVAIATGQLVWQIFTVDLLSPLDCGKKFVSNQWFGAIIFTGILLGRLFP
Function: Prenyltransferase involved in the biosynthesis of shikonin, a naphthoquinone secondary metabolite. Could accept only geranyl diphosphate and not dimethylallyl diphosphate, farnesyl diphosphate, or geranylgeranyl diphosphate as substrate. Catalytic Activity: (2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34319 Sequence Length: 307 Domain: The N-terminus (1-130) is determinant for the chain length specificity. Region I (76-96) and region III (201-229) are involved in the recognition of both substrates in a coordinated manner. Subcellular Location: Endoplasmic reticulum membrane EC: 2.5.1.93
O14031
MTARNSASIPTSIRKTSENEVSGDETPAGVGNLSTKTASKTSLTFRQSSSDESTSSYSGNHHNINIQHHPNRPFRTNSSSFSPNDYSISESPSKSKKDGVHVSAVQLDNETDSEVESEVEELERELEAIEDSVYPEVRAAVNPTDDVNLPVNTWRTWVLTTIFVIVFAAVNQFFSLRYPALSISFIVAQLILFPLGKLLNLLPNWKIGYGRFSFYLNSSPFNVKEHAAITIAVSLTSSTAYATNILSAQTSFYKQNLSWGYKILIVLTSQMLGYGFAGLTRRWIVYPAAMIWPQTLVSTVLFRTLHGNSGNDIGVLKNNRISANGWTISRYRFFAYVMIGSFVFYWFPGFIFKGLSYFTVLCWIWPKNRVVNQLFGYNSGLGILPLTFDWQQVVYNSNPLASPWWVICNTFGSVVLIFWIVVPILYYKGVWFSNYLPMLSSSTFDHTGVSYNSSRVLNSDYSFNHTKYESYSPLYMPMSYSMSTALNFAAVTAIFTHCALYNGKDIWQRLWKESGKDECIHRKLMRNYKEAPQWWYATLFIVVFGLTIFTVRYYDTQCPVWALIVALLIFIVNFIPQGVLEGITNQHVGLNIITELIGGYILPGKPLANLMIKLYGFIPMRQGLEFSRDLKLAQYMKIPPRILFFVQLFATILGGITQVAVQEWMNYHIPGICTTSQSNGFTCPNGRSIYNASLIWGAIGPAKMFSKGKPYYPLIFFFLIGAVAPFITWGLRKRFPKSWIGKLNAPVLFTGPGNIPPATGINYSSWAIVGFIFNYVIRKRAIHWWRKYNYVLAAAMDSGVAVAGVVIFLCVSYPGGKITWWGNTVYTKTYDWKSVPYRSLGPNETFGYTNW
Function: High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 96302 Sequence Length: 851 Subcellular Location: Endoplasmic reticulum membrane
Q8VYB7
MHGRPRNASKPEEEAASAAKAVQLRSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRKLAVEDRLARIEPDPNLVSAILDEELRVVESALRQNFKSYGAWHHRKWVLSKGHSSVGNELRLLEKFQKLDSRNFHAWNYRRFVVELTNRSEQDELQYTDDMINNNFSNYSAWHNRSVLLSSLLAQNADGFMPNIKIPEEYDFVHSAIFTEPDDQSGWFYHLWLLDQTLNVETPLLTSSWPSHGSSIILSGAGCLSGSSSMFTTFCSESGSFPLILYFDQAVGGVSSSTVTIDSELKGNEGLVWEPIPNKNSQVSCVWVARLKYVSSDPCEYKVKIRVGNSPGIVSSRGYNFNAPYEFVFTAHVHDTVEDSQEGIVSWTDGFDIWDAKSKDLNSLVTLDRLNAEMDFKWRQEAIDSEVECFGILPDSKIGKLTLARLLMAREAMVSDDAVKGVHYEEILQLYNDLMALDSSHYQYYKDEHSKAFLHKVTSSSESLSRHLLRYRDMNNLVCLRLNNLSLSRIASVEKLLFVQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSALDSLRHVKQLKVLDVSHNHIGKHSVDTTRYLCSSPLSNSELGQDDVGKQNPGLVTKYWDAYCVLTDLNLKQLDIAGNEIAGEEFSSFVLQVVPKLVWLDGQKKLGN
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -CCXX, CXXX, -XCCX and -XCXC, such as RABA1A, RABA2A, RABF2A and RABG2 . In vitro, can prenylate PGGTI targets with the C-terminal Cys-aliphatic-aliphatic-X (CaaX) with leucine in the terminal position. Substrates with the C-terminal sequence -CSIL such as ARAC11/ROP1 or GG2/AGG2 are prenylated independently of REP and when the alpha subunit is associated with a beta subunit (RGTB1 or RGTB2) . Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Mass (Da): 76909 Sequence Length: 678 EC: 2.5.1.60
Q9FJ32
MHGRKREEDPNPEETAAKALELRSLQSQFMSNHHQKIYTKEAIQLSAKLLITNPEFYTAWNYPKLAFESRLDEDSDPSLVNSIIDEELGVVQNALERNVKSYGAWYHRKWVLSKKGHYYPSLENELQLLNDYQKQAHQKQDDEKQDDPSRNFHAWNYRRFVVELTKTSEEDELQYTTDMISDISFTIYSAWHYRSVLVSSLVAKKADGFMPKETIRRELDYVHSAIFTLEEKQSGWFYYLWLLDQTVKMEIPLRFSSWPSDGSIIILSGPDCFNASSSTTKLTTFCSESGSFPLILYFDQAVSGVSSSTVTIGSELKDLVWEPVSDKKNSQVDSCVWVARLKFDCREPCFSRKETKVKVSLGGIVSSMGCNLTAPYEFVFTLRIHDTVEVELSQQESIVSWTDGFDNWDDNALSNDLNSLTALNADTGFEWRKKAIKIEIELFRTLPDSKIGKLILARLLMAEETMISNGVHYKEILQLYNDLMALDSWHNQYYKDEHSVALIHKVTSRTESMSRHLFRYRNMNNIICLRLNNLTLSRIAAVEKLLFVQMLDLSHNELHSAEGLEAMQLLCCLNLSHNRIRSFSALDSLRHLKQLRVLDVSHNHICGELPVDTTRYLCSSPLSNSGETGREVPNKYQDAYLVLRDLMKLKQLDIRGNDLIFAGEEFSSFVRQVVPKLVWLDGHKLTS
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -CCXX, CXXX, -XCCX and -XCXC, such as RABA1A, RABA2A, RABF2A and RABG2 (By similarity). Does not seem to be a functional Rab-GGT alpha subunit in vitro . Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Mass (Da): 79141 Sequence Length: 687 EC: 2.5.1.60
O93829
MQHGIKRVKLSEEAKRLKLEKDQIKIKNYRQLTDEIFELRANENYSDEALIKTNELLIINPEFYTIWNYRREILINNYSSSNDKDDQIYEDILNQDLNFVLVQLKKFPKCYWIWNHRRWLLFELVKLGKVNWKYEFGVVSKLLDLDQRNFHGWHYRRFVVKNMELECKNDTTLILKINLDEFNYTTLKIQKDFSNFSAWHNRTKLIPKIYNLIQQQQQQQQKDGKIFGDLPGIELFQNPILLLKNDLEMIKTGVYMSPEDTSVWLYLYWLLTDDLFTNAFKSHQQDYMNILHEQLQLINEVNEMEKEDTGQDNVGCLKSMIFINALIQNENNKPVLTEQVKSCLKQLAKIDPLRKNKYLDQLAGNAPIFHH
Function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 (By similarity). Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Mass (Da): 44462 Sequence Length: 371 EC: 2.5.1.60
Q55DQ4
MHGVLKVRTSEEKAKAQRLKELEKIESYNKLVKSFEELREKQNGRYDEISLSVSKLVLIENPEFYTIWNYRRLAILQFTETKENSELQVIYQNEMKFLEECIQRFTKSYWIWFHRQWIALRMDNCDWEREMKLCTKLLNFDLRNFHCWGHRRFILKHSNIKLEDELKYTTEKVEQNFSNYSAWHQRSSILPKIYKEPEQLLEKILEEFELVRNAVYTEPKDSSSWIYHKWLVATIKSIPNSNYIEVLKNELTQIYDLIELEPDCKWPIYTTLLLKIEIGGFEKQELLDIISQLIKLDPDHKNYYKSLETKI
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to proteins with a C-terminal sequence motif -XCC or -XCXC, where both cysteines may become modified. Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Mass (Da): 37779 Sequence Length: 311 EC: 2.5.1.60
Q92696
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Mass (Da): 65072 Sequence Length: 567 EC: 2.5.1.60
Q3MHI4
MAQEAGDMDDGQVSDSDSDMTVAPSDRPLPVPKALGGDCGLRPFQSTATACAPASHYRTVKSVDSSEESFSDSDDDSSVWKRKRQKCFNTPPKPEPFQFDQSSQKPPIAGRKKVNNIWSAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLKRESQEHTKELDKELEEYMHGGKKTGPKEEENGQGHPKRKRPVKDRVGDRLEMNYKGRYEITEDDSQERVADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYLENQKEYENKKAARKRRIQVMGKKMKQAIKNLNFQEDDDTSRETFASDTNEALASLDESQEGHGETKLDAEEAIEVDHSHDLDMF
Function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm. Sequence Mass (Da): 44578 Sequence Length: 394 Subcellular Location: Nucleus
Q9H814
MALEVGDMEDGQLSDSDSDMTVAPSDRPLQLPKVLGGDSAMRAFQNTATACAPVSHYRAVESVDSSEESFSDSDDDSCLWKRKRQKCFNPPPKPEPFQFGQSSQKPPVAGGKKINNIWGAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLRKESQEHTKDLDKELDEYMHGGKKMGSKEEENGQGHLKRKRPVKDRLGNRPEMNYKGRYEITAEDSQEKVADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYIENQKEYENKKAARKRRTQVLGKKMKQAIKSLNFQEDDDTSRETFASDTNEALASLDESQEGHAEAKLEAEEAIEVDHSHDLDIF
Function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm (By similarity). Sequence Mass (Da): 44403 Sequence Length: 394 Subcellular Location: Nucleus
Q9JJT9
MALEAGDMEEGQLSDSDSDMTVVPSDRPLQMAKVLGGGSAACAPVSHYRTVKHVDSSEESLDSDDDCSLWKRKRQKCHNTPPKPEPFPFGPSGQKTALNGGKKVNNIWGAVLQEQNQDAVATELGILGMEGSIDRSRQSETYNYLLAKKLAKKESQEYTKELDKDLDEYMHGDKKPGSKEDENGQGHLKRKRPVRDRLGNRVEMNYKGRYEITEEDAPEKVADEIAFRLQEPKKDLIARVVRILGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYVENQKEYENKKAARKRRTQLLGKKMKQAIKSLNFQEDDDTSRETFASDTNEALASLDEAQEGPGETKLDAEEAIEVDHPQDLDIF
Function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm. Sequence Mass (Da): 43247 Sequence Length: 385 Subcellular Location: Nucleus
Q63068
MALEAGDMEEGQLSDSDSDMTVVPSDRPLQMAKVLGGGGAACAPVSNYRTVKHVDSSEESLDSDDDCSLWKRKRQKCHSPPPKPEPFPFGQSGQKPALNGGKKVNNIWGAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLAKKESQEYTKELDKDLDEYMHGDKKPGSKEEENGQGHLKRKRPVRDRLGNRVEMNYKGRYDITEEDSPEKVADEIAFRLQEPKKDLIARVVTILGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYIENQKEYENKKAARKRRTQLLGKKMKEAIKSLNFQEDDDTSRETFASDTNEALASLDEAQEGPGETKLDAEDAIEVDHPQDLDIF
Function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm. Sequence Mass (Da): 43166 Sequence Length: 385 Subcellular Location: Nucleus
Q51718
MPLRTLLCGLLLAVCLGQHALAASRCSERPRTLLRPAEVSCSYQSTWLDSGLVGQRKIIYQTPLGTPPAGGWPVVLIYQGSFFPLNDFSYHSNLPFGGYYEGKLVQNLLDHGYAVIAPSAPADLFWQTNIPGLAQAYELSTDYDFLGNVLAAIASGHFGPLNAQRQYATGISSGGYNTSRMAVSFPGKFRALAVQSGSYATCSGPLCVVPDQLPADHPPTLFLHGFVDAVVPWWSMDLYYDRLLHQGIETARYTEPLGGHEWFAASPGKVLAWFNAHP
Function: Hydrolysis of poly(3-hydroxyoctanoic acid). Catalytic Activity: Hydrolyzes the polyester poly{oxycarbonyl[(R)-2-pentylethylene]} to oligomers. Sequence Mass (Da): 30267 Sequence Length: 278 Subcellular Location: Secreted EC: 3.1.1.76
B2NHN2
MFDSVKIAWLVALGAAQVAATALPAFNVNPNSVSVSGLSSGGYMAAQLGVAYSDVFNVGFGVFAGGPYDCARNQYYTSCMYNGYPSITTPTANMKSWSGNQIASVANLGQRKIYMWTGSSDTTVGPNVMNQLKAQLGNFDNSANVSYVTTTGAVHTFPTDFNGAGDNSCSLSTSPYISNCNYDGAGAALKWIYGSLNARNTGTLSGSVLSFAQSGSYGANGMDTTGYLYVPQSCASGATVCSLHVALHGCLQSYSSIGSRFIQNTGYNKWADTNNMIILYPQAIPDYTIHAIWNGGVLSNPNGCWDWVGWYGSNADQIGGVQMAAIVGQVKQIVSGFQG
Function: Esterase involved in the hydrolysis of polyhydroxybutyrate, a microbial polyester that can be produced from renewable resources. Catalytic Activity: [(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) Sequence Mass (Da): 35613 Sequence Length: 339 Subcellular Location: Secreted EC: 3.1.1.75
O49460
MNNVKVPKIPGGGAISTLLKVGIIGGLGLYGATHSLYNVEGGHRAIMFNRLVGIKDKVYPEGTHLMIPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRSLGENYSERVLPSIINETLKAVVAQYNASQLITQREAVSREIRKILTERAANFNVALDDVSITNLTFGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTIANSANKVYLSSDDLLLNLQGMNLDVDAKN
Function: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 31706 Sequence Length: 288 Subcellular Location: Mitochondrion inner membrane
Q44104
MSRIAYFGPVGTFTEQAARTFMAAGDELVAAETIPKALDAVRRGEADAACVPVENSVEGAVPATLDSLAVGEPLIGVAEALLPVHFSVLTRDDVGEIRTVASHPHALAQVRKWLEDNLPGARVVAAGSTAAAAVAVQAGEFDAAVTAPVAVEHYPLKVLATEVADVRDARTRFLLMRRPPVVLPEPTGADRTSIVAAAANRTGTLAELLTELATRGINLTRLDARPHKQNFGEYRFFIDFEGHVAEPRIADALAALRRRCRDVRFLGSFARADGVAATIEPAARNEDFTDAADWVAAVQRGEQA
Catalytic Activity: H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O Sequence Mass (Da): 32321 Sequence Length: 304 Pathway: Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1. EC: 4.2.1.51