ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
O34705
MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGDLPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQRNPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEADQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWFNGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI
Function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis reaction of one acyl bond in phosphatidylcholine in vitro (actual cleavage point is unknown), resulting in lysophosphatidylcholine. Sequence Mass (Da): 29566 Sequence Length: 259 Pathway: Antibiotic biosynthesis; bacilysocin biosynthesis. EC: 3.1.1.-
Q9XWV2
MNWIFIFLAAAVAIGCEARQERTYTVCQKPEGDLHYFKEGRKTDEELCAKRLATAYFHDEVNQTGWAFLEVDVISPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDGAKHFCDELGEFMVDNLKWMEQEIRENPEDEYWQQVNLTVNQLFGLIHGYENQLGAEIDFKQIAVHPIFMIQIAGDLEDLAMKFKKPENPKKVFSGPGHCSALVKLLPKNEDILFSHVTWSSYGTMLRINKKYSFKTGDPGQIYSFSSYPASITSTDDFVLTSAKLAILETTIGNYNEKSLDLITPNTVLTWIRAEIAHRTASSGLQWAEAFGRHNSGTYNNEWVVVDYKQFHRGKEVQPETGIIHVVEQMPGHIVHSDKTAHLFRETYWPGYNQPYYKQIIRFSDTDKMVEKFGDWYSYDKTPRALIFKRDHNTVTDMSSMIALMRSNNYTKDPLSKCDCNPPYSAENAIACRSDLNPLNGTYPFKSLGFRDHGAIDVKVTNSKLINSLQFTAVSGPPGGVTKDVPIFDWKTSPLREKVPHFGQPDRWNFAPVTYKWRKDAHRHYHLYQKLHKELSSL
Function: Putative phospholipase. Sequence Mass (Da): 65439 Sequence Length: 571 Subcellular Location: Lysosome EC: 3.1.1.-
Q6P4A8
MTRGGPGGRPGLPQPPPLLLLLLLLPLLLVTAEPPKPAGVYYATAYWMPAEKTVQVKNVMDKNGDAYGFYNNSVKTTGWGILEIRAGYGSQTLSNEIIMFVAGFLEGYLTAPHMNDHYTNLYPQLITKPSIMDKVQDFMEKQDKWTRKNIKEYKTDSFWRHTGYVMAQIDGLYVGAKKRAILEGTKPMTLFQIQFLNSVGDLLDLIPSLSPTKNGSLKVFKRWDMGHCSALIKVLPGFENILFAHSSWYTYAAMLRIYKHWDFNVIDKDTSSSRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVFNKTLLKQVIPETLLSWQRVRVANMMADSGKRWADIFSKYNSGTYNNQYMVLDLKKVKLNHSLDKGTLYIVEQIPTYVEYSEQTDVLRKGYWPSYNVPFHEKIYNWSGYPLLVQKLGLDYSYDLAPRAKIFRRDQGKVTDTASMKYIMRYNNYKKDPYSRGDPCNTICCREDLNSPNPSPGGCYDTKVADIYLASQYTSYAISGPTVQGGLPVFRWDRFNKTLHQGMPEVYNFDFITMKPILKLDIK
Function: In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. PTM: The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein. Sequence Mass (Da): 63255 Sequence Length: 553 Subcellular Location: Lysosome EC: 3.1.1.-
O62146
MTRLIRSKKQFLIRSLHSVFYYLGSLLHSTFEMNVFIGLLLATVVASQSSEGRDESYTYKQLCIVDDKPQVLDGFDCRNQVAVARWQNAVNTTGWTFLEVETKENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDYCKNFTGYCSRLSDFLTENQKWIQSSLETVAPDDLYWGAVNRTYHQVSGLIDAYEGREFKPRITYELHPILYLNLNGDFYDLEKKLNKTRDPAFEQTGGKCSGLIKVAPGNADLFISQVTMSGFQNMLRVIKLYKFGYDRQFYPGYASSFSSYPGLLYSSDDFALQTSGLAVIETTISVFNTSLFENTKPVGQLPTWIRAIVSNQLARDAREWCKLYSLYNSGTYNNQWAVLDYKKFKPNQPLPKNGLFYVLEQMPGKIVYSDLTWFVEKYSYFPSYNIPFFKEITEISGFIGQAAKMGDWFKWGASPRAKIFERDHGNVHDLDSLTALMRYNDYKNDEFSKCKCNPPYSAEAGISARGDLNPANGTYEFPGQGHVNHGALDYKGTNVELMKKLQFVAQGGPTWGKVPSFKWSEFDFKDKVNHVGHPDEWKFNTLVHKWETEINA
Function: Putative phospholipase. Sequence Mass (Da): 66638 Sequence Length: 582 Subcellular Location: Secreted EC: 3.1.1.-
Q8NHP8
MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEYEVGYCERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGSGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFREGPWGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGCVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPGSRVLTILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACNPQPNGENAISARSDLNPANGSYPFQALRQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSPFSGLLHMGQPDLWKFAPVKVSWD
Function: Putative phospholipase. PTM: The p76 protein is synthesized as a 80 kDa precursor which is then processed into a N-terminal 32 kDa form and a C-terminal 45 kDa form. Sequence Mass (Da): 65472 Sequence Length: 589 Subcellular Location: Lysosome lumen EC: 3.1.1.-
P59588
MFQQQKDWETRENAFAAFTMGPLTDFWRQRDEAEFTGVDDIPVRFVRFRAQHHDRVVVICPGRIESYVKYAELAYDLFHLGFDVLIIDHRGQGRSGRLLADPHLGHVNRFNDYVDDLAAFWQQEVQPGPWRKRYILAHSMGGAISTLFLQRHPGVCDAIALTAPMFGIVIRMPSFMARQILNWAEAHPRFRDGYAIGTGRWRALPFAINVLTHSRQRYRRNLRFYADDPTIRVGGPTYHWVRESILAGEQVLAGAGDDATPTLLLQAEEERVVDNRMHDRFCELRTAAGHPVEGGRPLVIKGAYHEILFEKDAMRSVALHAIVDFFNRHNSPSGNRSTEV
Catalytic Activity: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine Sequence Mass (Da): 38978 Sequence Length: 340 Subcellular Location: Cell inner membrane EC: 3.1.1.5
P44800
MIREPYFHQFALAELLPFFEQFPTQYLSGKRNIKLAYRHLIQPESAVRKLMILVNGRAENMLKWSELAYDFYHQGYDVLLFDHRGQGYSQRIIPQKGHLDEFRFYVDDMAKIIEKVTALFSYSTQHLLAHSMGALIATYYLANYDHHINKAVLSSPFYGILLKHPIRDELIITLMNILGQGERYVFGKGAYQQAHLEYNELTFCKTRMKWMNRINRKNPAINLGGPTFRWVHLCLNAIKRLPKVIPKIEIPILILQAEKEKIVDNKNLEKLTALFPNARCEVILNAKHEVLFEKDNVRRNVLKSVNHFLNVQS
Catalytic Activity: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine Sequence Mass (Da): 36658 Sequence Length: 313 Subcellular Location: Cell inner membrane EC: 3.1.1.5
Q9C5Y0
MAEKVSEDVMLLHGDLDLKIVKARRLPNMDMFSEHLRRLFTACNACARPTDTDDVDPRDKGEFGDKNIRSHRKVITSDPYVTVVVPQATLARTRVLKNSQEPLWDEKFNISIAHPFAYLEFQVKDDDVFGAQIIGTAKIPVRDIASGERISGWFPVLGASGKPPKAETAIFIDMKFTPFDQIHSYRCGIAGDPERRGVRRTYFPVRKGSQVRLYQDAHVMDGTLPAIGLDNGKVYEHGKCWEDICYAISEAHHMIYIVGWSIFHKIKLVRETKVPRDKDMTLGELLKYKSQEGVRVLLLVWDDKTSHDKFGIKTPGVMGTHDEETRKFFKHSSVICVLSPRYASSKLGLFKQQASPSSSIYIMTVVGTLFTHHQKCVLVDTQAVGNNRKVTAFIGGLDLCDGRYDTPEHRILHDLDTVFKDDFHNPTFPAGTKAPRQPWHDLHCRIDGPAAYDVLINFEQRWRKATRWKEFSLRLKGKTHWQDDALIRIGRISWILSPVFKFLKDGTSIIPEDDPCVWVSKEDDPENWHVQIFRSIDSGSVKGFPKYEDEAEAQHLECAKRLVVDKSIQTAYIQTIRSAQHFIYIENQYFLGSSYAWPSYRDAGADNLIPMELALKIVSKIRAKERFAVYVVIPLWPEGDPKSGPVQEILYWQSQTMQMMYDVIAKELKAVQSDAHPLDYLNFYCLGKREQLPDDMPATNGSVVSDSYNFQRFMIYVHAKGMIVDDEYVLMGSANINQRSMAGTKDTEIAMGAYQPNHTWAHKGRHPRGQVYGYRMSLWAEHLGKTGDEFVEPSDLECLKKVNTISEENWKRFIDPKFSELQGHLIKYPLQVDVDGKVSPLPDYETFPDVGGKIIGAHSMALPDTLTT
Cofactor: Ca(2+). Requires millimolar level (PIP2-dependent). Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). May be involved in PA accumulation in the dehydration stress response and in the transduction of hormonal and environmental signals to the microtubules cytoskeleton . Prefers phosphatidylethanolamine to phosphatidylcholine as substrate . Involved in H(2)O(2) and abscisic acid (ABA)-induced stomatal closure . Involved in nitric oxide (NO) signaling during stomatal closure . Plays a positive role in ABA-promoted senescence . Involved in basal defense and nonhost resistance . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) Location Topology: Peripheral membrane protein Sequence Mass (Da): 98917 Sequence Length: 868 Domain: C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD delta, all the calcium-coordinating acidic amino acids are conserved. Subcellular Location: Cell membrane EC: 3.1.4.4
Q9T053
MAYHPAYTETMSMGGGSSHGGGQQYVPFATSSGSLRVELLHGNLDIWVKEAKHLPNMDGFHNRLGGMLSGLGRKKVEGEKSSKITSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDSDIIGSQIMGAVGIPTEQLCSGNRIEGLFPILNSSGKPCKQGAVLGLSIQYTPMERMRLYQMGVGSGNECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRQARRLIYITGWSVFHPVRLVRRTNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSRSLLGFKTQGVMNTSDEETRRFFKHSSVQVLLCPRSGGKGHSFIKKSEVGTIYTHHQKTVIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHPLFRTLKTLHKDDFHNPNFVTTADDGPREPWHDLHSKIDGPAAYDVLANFEERWMKASKPRGIGKLKSSSDDSLLRIDRIPDIVGLSEASSANDNDPESWHVQVFRSIDSSSVKGFPKDPKEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRAREKFAAYIVIPMWPEGAPTSNPIQRILYWQHKTMQMMYQTIYKALVEVGLDSQFEPQDFLNFFCLGTREVPVGTVSVYNSPRKPPQPNANANAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHYSWAMKGSRPHGQIFGYRMSLWAEHLGFLEQGFEEPENMECVRRVRQLSELNWRQYAAEEVTEMSGHLLKYPVQVDRTGKVSSLPGCETFPDLGGKIIGSFLALQENLTI
Cofactor: Ca(2+). Requires micromolar level (PIP2-dependent). Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence . Can use phosphatidylserine (PS) and phosphatidylethanolamine (PE) as substrates only in the presence of PIP2. Can use phosphatidylcholine (PC), phosphatidylglycerol (PG) or N-acylphosphatidylethanolamine (NAPE) as substrates in the presence of PE and PIP2 . Involved in membrane lipid modulation under aluminum (Al) stress and negatively modulate plant tolerance to Al . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) Location Topology: Peripheral membrane protein Sequence Mass (Da): 95588 Sequence Length: 858 Domain: C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD gamma, all the calcium-coordinating acidic amino acids are conserved. Subcellular Location: Cytoplasm EC: 3.1.4.4
Q9T051
MSMGGGSNHEFGQWLDQQLVPLATSSGSLMVELLHGNLDIWVKEAKHLPNMICYRNKLVGGISFSELGRRIRKVDGEKSSKFTSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDNDPIGSKIIGVVGIPTKQLCSGNRIEGLFPILNSSGKPCRKGAMLSLSIQYTPMERMRLYQKGVGSGVECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRRARRLIYITGWSVFHPVRLVRRNNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSMSFPGFSTKGLMNTSDEETRRFFKHSSVQVLLCPRYGGKGHSFIKKSEVETIYTHHQKTMIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHSLFGTLKTLHKDDFHNPNFVTTEDVGPREPWHDLHSKIDGPAAYDVLANFEERWMASKPRGIGKGRTSFDDSLLRINRIPDIMGLSEASSANDNDPESWHVQVFRSIDSTSVKGFPKDPEEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRARENFAAYIVIPMWPEGAPTSKPIQRILYWQHKTMQMMYQTIYKALLEVGLDGQLEPQDFLNFFCLGNREVGTREVPDGTVNVYNCPRKPPQPNAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHHSWAKKGSRPRGQIFGYRMSLWAEHLGFLEQEFEEPENMECVRRVRQLSELNWGQYAAEEVTEMSGHLLKYPVQVDKTGKVSSLPGCETFPDLGGKIIGSFLTLQENLTI
Cofactor: Ca(2+). Requires micromolar level (PIP2-dependent). Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine but prefers ethanolamine-containing lipids as substrates. Can use phosphatidylcholine (PC) as substrates in the presence of phosphatidylethanolamine (PE) and PIP2 . Involved in membrane lipid modulation under aluminum (Al) stress and negatively modulate plant tolerance to Al . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) Location Topology: Peripheral membrane protein Sequence Mass (Da): 96024 Sequence Length: 856 Domain: C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD gamma, all the calcium-coordinating acidic amino acids are conserved. Subcellular Location: Cytoplasm EC: 3.1.4.4
Q86AV9
MKNKIILLWLLLIVILCTISNVKGCGMTTHNTVARRAYNFSSFDGFEQYQKYVSENFDVFDAGAAFPDFGYDCGGLANESEAAHWPPFLRAATKYLLETYPQPWSLDGIRLAVFLLGVTSHQIADISWHSIGGIQQGLIRAMAGQDFNGTYELAHGNADEGGEFELAYNYDLSWLSDKWYVPITDIKNIFHSMNYPRVDDENLLRCNAILYAGAMGVKIGGRFFYPEIAKKSPFLVDHYQDYFIGGLDDMSIWTSYCWPVLMGWMDGEDIGDFCFIQPDPNNDDDNQHLRLHHKHSILKNGSKIKEALSKSILNEMKITNNGKGVTFSLPNSMEKAINQVLNKFNQNPIGTLLEKYLPNLFNNKNKFYQENENEQYNHDEEELNIIDIDIDIEEEEQEEEEDKPIRMLSKNNNFKNYEYLNDKKKSSSSKLKNKSKKNIIKLNSDSNDLGTNFTTIYGQNMYSYFGKDIRSKDLNGDGFDDLIISSPGFGVPGSMQTGCVYYIISNGSSVTIDGGSGFTSEFDIDQVATGKLCGNETHAKFGWNIDVLDFNLDGIFDIIIGAPSSSNANLQYLGMIYIYLGEKNNPAGEWSTESDLPSITIQGIEYADTIGTVLRVADCNADSNADLILGSPHSAGGGTQRGTVQIFYSSKKRISGIPISLNDADYYGHGEVDYEWFGYEIKVAGQGDSSTLLVGSPNYHDEETAIVNIGKITSFPYNVNLNSFDLNPKFVMVGVNKNDKLGYSYNMVNGSLFGLDNVNDIMVLSLPTRGFGDDFDQVGEVVLIDIDNLSGFVEIKNVNLLLSIKGTTKYSRFGESLLIGKLESTDEFARLFVGAPLWTDSIDTGPGCVFTFLPNQHLTNDPAVLKQNIINNTPVVIYDSTHSIKTFRIDDDSGSSGGRSFNNKRKDSRFGFRILLSDFNNDGKNDLIVSADRDSSKILEGGSINIFQ
Cofactor: Binds Ca(2+). Function: Hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. May also cleave GPI anchor intermediates intracellularly. Catalytic Activity: an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) Sequence Mass (Da): 105705 Sequence Length: 948 Subcellular Location: Secreted EC: 3.1.4.50
Q988B7
MTERLAGKTALVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASIGKKARAIAADISDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRAGTDQMRAAGKAGRVISIASNTFFAGTPNMAAYVAAKGGVIGFTRALATELGKYNITANAVTPGLIESDGVKASPHNEAFGFVEMLQAMKGKGQPEHIADVVSFLASDDARWITGQTLNVDAGMVRH
Function: Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphate, 4-phthalaldehyde, 2-nitrobenzaldehyde, pyridine, formaldehyde, 2-carboxybenzaldehyde or sugars. Catalytic Activity: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH Sequence Mass (Da): 25531 Sequence Length: 248 Pathway: Cofactor degradation; B6 vitamer degradation; 4-pyridoxate from pyridoxal: step 1/2. EC: 1.1.1.107
O17405
MPLRLINFRQQRRCRQSPSVARLESIVLNRRELLLDHFQYSLFQNSSEIPMTTILINDRPMRHTHDGRADMTNFEMDLFDTRIEVPTSKNSGGDGMHSPYYDEESSKKRCCKCGNSRNRIIKPACVPISIVSLFIIALVFLPLFNEEDLASPIKLTTGCSVDCKTFLVESIPIGLPFKTNNHTAEAWINIIDNSKQYLDISVMYWNLNTSDYKSSVYGRRVYEAIIRAGKRGVKIRIAQDGASNLSDNKESAYLVQEGLAEVREINVTRLIGSGIIHTKFILSDIATLYIGSANMDWKSLSEVKEVGVVFQECPCVASDLYKIFAAYWKLGENDSVIPEKWPISYRTPFNFSSMAKLTMDGEPAEYFISSSPGPFNPKGREHDLAAIQKIMKDARKSVCISVMDYIPSTLYMKKSNRFWPEIDDSIRDAAYRGVNVRMLISHWDHSRKEMIPFLKSLQTITDGLPRYNRTEHGQVQVRIFTVPPNGKEKIPFTRVNHAKYMVTEDIAYIGTSNWSGDYFISTAGVAMVVRQPSATKRLQNVFDRDWNSEYSKDL
Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 63216 Sequence Length: 554 Subcellular Location: Membrane EC: 3.1.4.4
Q8IUK5
MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC
Function: Plays a critical role in endothelial cell capillary morphogenesis. PTM: N-glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 55760 Sequence Length: 500 Subcellular Location: Secreted
Q91ZV7
MRAQLWLLQLLLLRGAARALSPATPAGHNEGQDSAWTAKRTRQGWSRRPRESPAQVLKPGKTQLSQDLGGGSLAIDTLPDNRTRVVEDNHNYYVSRVYGPGEKQSQDLWVDLAVANRSHVKIHRILSSSHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDMLHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQDREDRGSFTFQAALHRDGRIVFGYKEIPMAVLDISSAQHPVKAGLSDAFMILNSSPEVPASQRRTIFEYHRVELDSSKITTTSAVEFTPLPTCLQHQSCDTCVSSNLTFNCSWCHVLQRCSSGFDRYRQEWLTYGCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDSTTSSSLFIDSLTTEDDTKLNPYAEGDGLPDHSSPKSKGPPVHLGTIVGIVLAVLLVAAIILAGIYISGHPNSNAALFFIERRPHHWPAMKFHNHPNHSTYTEVEPSGHEKEGFVEAEQC
Function: Plays a critical role in endothelial cell capillary morphogenesis. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 55635 Sequence Length: 500 Subcellular Location: Cell membrane
Q54K50
MIINRLFIIIVLFFVNVNSKIISESTLNSCQGGTIQIAESIPLGLDISTNLSTHDAWMDLITNAQESIDLGFFYFTLLGGSDLDPVYGGQLGIDIFNAIVEAHSRGINVRIVQNEPSESFPDTETQTLAKLGIQVRSIDWVSLVGSGVLHTKLIIIDESSAYVGSANADWSSLAQVKELGIVLKNCPTMVADTEIAFQQYWNAADFTSLPINDWGSNYQALFNNTNMASLSLNNNNNNNNKNKNNDNDGSGTNQMYEMFLAVSPPQFQSTYRTGDIDALMDAINNADQSICITVMDYTPTTLYNDPNTYWPLIDNALRAAAFNRNVQVRMLISHWNYTSPIIPQWLHSLNQVDNIQVRWFVVPDFSTNPQIPYTRVNHAKFMVTEKQSYVGTSNWSQDYFTVTGGLSYNVFNNDFTNQLQSIFNRDWNSPYTQPIQNF
Function: Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) Sequence Mass (Da): 49186 Sequence Length: 438 EC: 3.1.4.4
P20626
MREKVVLFLSIIMAIMLPVGNAAAAPVVHNPASTANRPVYAIAHRVLTTQGVDDAVAIGANALEIDFTAWGRGWWADHDGIPTSAGATAEEIFKHIADKRKQGANITFTWLDIKNPDYCRDARSVCSINALRDLARKYLEPAGVRVLYGFYKTVGGPAWKTITADLRDGEAVALSGPAQDVLNDFARSENKILTKQKIADYGYYNINQGFGNCYGTWNRTCDQLRKSSEARDQGKLGKTFGWTIATGQDARVNDLLGKANVDGLIFGFKITHFYRHADTENSFKAIKRWVDKHSATHHLATVADNPW
Function: Virulence factor affecting bacterial dissemination and survival within the host . Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC) . Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization . Shows hemolytic activity . Catalytic Activity: a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+) Sequence Mass (Da): 33884 Sequence Length: 307 EC: 3.1.4.-
O00469
MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
Function: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Location Topology: Peripheral membrane protein Sequence Mass (Da): 84686 Sequence Length: 737 Subcellular Location: Rough endoplasmic reticulum membrane EC: 1.14.11.4
O60568
MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP
Function: Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen . Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens . Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine . Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues . Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues . Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes (By similarity). Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Location Topology: Peripheral membrane protein Sequence Mass (Da): 84785 Sequence Length: 738 Domain: The N-terminal domain mediates glycosyltransferase activity. Subcellular Location: Rough endoplasmic reticulum
Q9R0E1
MAAAGPEPRLLLLLLLLLPPLPPVTSASDRPRGANAVNPDKLLVITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEKYADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPEWGLAEQYPEVGMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPGLREKLKLSLDHKSRIFQNLNGALDEVILKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGWTPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLFLHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYFSLDADAVLTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLHLSNQHEFGRLLATSRYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEYLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVDP
Function: Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen . Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens . Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues . Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues . Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues . Essential for normal biosynthesis and secretion of type IV collagens . Essential for normal formation of basement membranes . PTM: N-glycosylated. Location Topology: Peripheral membrane protein Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Sequence Mass (Da): 84922 Sequence Length: 741 Domain: The N-terminal domain mediates glycosyltransferase activity. Subcellular Location: Rough endoplasmic reticulum
Q20679
MRVLPFLLPLIPVLLATTITDLPELVVVTVATENTDGLKRLLESAKAFDINIEVLGLGEKWNGGDTRIEQGGGQKIRILSDWIEKYKDASDTMIMFVDAYDVVFNADSTTILRKFFEHYSEKRLLFGAEPFCWPDQSLAPEYPIVEFGKRFLNSGLFMGYGPEMHKILKLKSVEDKDDDQLYYTMIYLDEKLRKELNMDLDSMSKIFQNLNGVIEDVELQFKEDGTPEAYNAAYNTKPLIVHGNGPSKSHLNYLGNYLGNRWNSQLGCRTCGLEVKESEEVPLIALNLFISKPIPFIEEVLQKIAEFDYPKEKIALYIYNNQPFSIKNIQDFLQKHGKSYYTKRVINGVTEIGDREARNEAIEWNKARNVEFAFLMDGDAYFSEPKVIKDLIQYSKTYDVGIIAPMIGQPGKLFTNFWGAIAANGYYARSEDYMAIVKGNRVGYWNVPFITSAVLFNKEKLEAMKDAYSYNKNLDPDMSMCKFARDNGHFLYIDNEKYYGFLIVSDEYAETVTEGKWHPEMWQIFENRELWEARYIHPGYHKIMEPEHVVDQACPDVYDFPLMSERFCEELIEEMEGFGRWSDGSNNDKRLAGGYENVPTRDIHMNQVGFERQWLYFMDTYVRPVQEKTFIGYYHQPVESNMMFVVRYKPEEQPSLRPHHDASTFSIDIALNKKGRDYEGGGVRYIRYNCTVPADEVGYAMMFPGRLTHLHEGLATTKGTRYIMVSFINP
Function: Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen . Catalyzes the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in type IV collagens (By similarity). Transfers galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Catalyzes the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues . Essential for normal biosynthesis and secretion of type IV collagens . Essential for normal stability of the basement membrane . Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Location Topology: Peripheral membrane protein Sequence Mass (Da): 84425 Sequence Length: 730 Domain: The N-terminal domain mediates glycosyltransferase activity. Subcellular Location: Rough endoplasmic reticulum
Q9VTH0
MRIQQSALLLLLLAVTSQGDAESNWNDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKGGDMQKPGGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEKYCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVDPIEDTADDQLYFTKIFLDETKRAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYLARTFNGVCLLCQENLLDLEETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQSDYIFFVDADAHIDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSIYLVKKTAFDAISFKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMISFIDP
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Forms hydroxylysine residues in collagen type IV (By similarity). Required for the secretion of collagen type IV (vkg) from haemocytes, fat body and follicle cells . Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Sequence Mass (Da): 82510 Sequence Length: 721 Subcellular Location: Endoplasmic reticulum
Q5UQC3
MISRTYVINLARRPDKKDRILAEFLKLKEKGVELNCVIFEAVDGNNPEHLSRFNFKIPNWTDLNSGKPMTNGEVGCALSHWSVWKDVVDCVENGTLDKDCRILVLEDDVVFLDNFMERYQTYTSEITYNCDLLYLHRKPLNPYTETKISTHIVKPNKSYWACAYVITYQCAKKFMNANYLENLIPSDEFIPIMHGCNVYGFEKLFSNCEKIDCYAVQPSLVKLTSNAFNDSETFHSGSYVPSNKFNFDTDKQFRIVYIGPTKGNSFHRFTEYCKLYLLPYKVIDEKETNDFVSLRSELQSLSEQDLNTTLMLVVSVNHNDFCNTIPCAPTNEFIDKYKQLTTDTNSIVSAVQNGTNKTMFIGWANKISEFINHYHQKLTESNAETDINLANLLLISSISSDFNCVVEDVEGNLFQLINEESDIVFSTTTSRVNNKLGKTPSVLYANSDSSVIVLNKVENYTGYGWNEYYGYHVYPVKFDVLPKIYLSIRIVKNANVTKIAETLDYPKELITVSISRSEHDSFYQADIQKFLLSGADYYFYISGDCIITRPTILKELLELNKDFVGPLMRKGTESWTNYWGDIDPSNGYYKRSFDYFDIIGRDRVGCWNVPYLASVYLIKKSVIEQVPNLFTENSHMWNGSNIDMRLCHNLRKNNVFMYLSNLRPYGHIDDSINLEVLSGVPTEVTLYDLPTRKEEWEKKYLHPEFLSHLQNFKDFDYTEICNDVYSFPLFTPAFCKEVIEVMDKANLWSKGGDSYFDPRIGGVESYPTQDTQLYEVGLDKQWHYVVFNYVAPFVRHLYNNYKTKDINLAFVVKYDMERQSELAPHHDSSTYTLNIALNEYGKEYTAGGCEFIRHKFIWQGQKVGYATIHAGKLLAYHRALPITSGKRYILVSFVN
Function: Displays two enzymatic activities involved in procollagen processing. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines are subsequentially glucosylated by a glucosyltransferase activity. Collagen post-translationally modified is detected in mimivirus virion. Catalytic Activity: 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate Sequence Mass (Da): 103501 Sequence Length: 895 EC: 1.14.11.4
Q10022
MRDHVEFCYYVIIYSLEKFQQRSKQFGISLFIFFLATAAVTVIVPTLLGVSQRGFFCDDDSIRYEYRKDTITAVQLMLYNLVLNAATVLFVEYYRMQKVESNINNPRYRWRNNHLHVLFVRLLTYFGYSQIGFVMNIALNIVTKHVVGRLRPHFLDVCKLANDTCVTGDSHRYITDYTCTGPPELVLEARKSFYSGHSAVSLYCATWSALYIQARLGPVLNNRIVVPISQTLMFMIGLGISFSRITDNKHHWSDVLVGIFIGIFLAVYTCTFWTDLFSNNSTESETQPLLLPRPPRTPRNSEDEERHRLDAVLPSTDSSIVFEATGPQDSDTILLPVPQSA
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39028 Sequence Length: 341 Subcellular Location: Membrane EC: 3.1.3.-
O23179
MENKSPSKKNKPPSCGSLVTILSLDGGGVRGIIAGVILAFLEKQLQELDGEEARLADYFDVIAGTSTGGLVTAMLTVPDETGRPHFAAKDIVPFYLEHCPKIFPQPTGVLALLPKLPKLLSGPKYSGKYLRNLLSKLLGETRLHQTLTNIVIPTFDIKKLQPTIFSSYQLLVDPSLDVKVSDICIGTSAAPTFFPPHYFSNEDSQGNKTEFNLVDGAVTANNPTLVAMTAVSKQIVKNNPDMGKLKPLGFDRFLVISIGTGSTKREEKYSAKKAAKWGIISWLYDDGSTPILDITMESSRDMIHYHSSVVFKALQSEDKYLRIDDDTLEGDVSTMDLATKSNLENLQKIGEKMLTNRVMQMNIDTGVYEPVAENITNDEQLKRYAKILSDERKLRRLRSDTMIKDSSNESQEIK
Function: Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Catalyzes the hydrolysis of the neutral lipids monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and phosphatidylglycerol (PG), and less efficiently the polar lipids phosphatidylcholine (PC) and phosphatidylinositol (PI), but not the storage lipid triacylglycerol (TAG). May play a role in root development. PTM: Phosphorylated at Ser-399 by CPK3. Phosphorylation enhances PLP1 activity towards phosphatidylcholine. Sequence Mass (Da): 45824 Sequence Length: 414 Domain: The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. Subcellular Location: Cytoplasm EC: 3.1.1.-
Q84QY3
MAASYSCRRTCEACSTRAMAGCVVGEPASAPGQRVTLLAIDGGGIRGLIPGTILAFLEARLQELDGPDARLADYFDCIAGTSTGGLITAMLAAPGDHGRPLFAASDINRFYLDNGPLIFPQKRCGMAAAMAALTRPRYNGKYLQGKIRKMLGETRVRDTLTNVVIPTFDVRLLQPTIFSTYDAKSMPLKNALLSDICISTSAAPTYLPAHCFQTTDDATGKVREFDLIDGGVAANNPTMVAMTQITKKIMVKDKEELYPVKPSDCGKFLVLSVGTGSTSDQGMYTARQCSRWGIVRWLRNKGMAPIIDIFMAASSDLVDIHAAVMFQSLHSDGDYLRIQDNTLHGDAATVDAATRDNMRALVGIGERMLAQRVSRVNVETGRYVEVPGAGSNADALRGFARQLSEERRARLGRRNACGGGGEGEPSGVACKR
Function: Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance (By similarity). Sequence Mass (Da): 46400 Sequence Length: 432 Domain: The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. EC: 3.1.1.-
W7K139
MSDDDDKIYIYSDLFSKNFSDDEKDDSYEREKQVYSGSETQNAENEYSKLRAQNSTILNNYFDNDNIKNVENLKSNDPDQIDLILFPVNKNYYMNLFDGQLIENIHSIKLRKAGFYAIYVENNNNSKWDGIYFGLSRMQVELDYKLITKKNKDGGEYEKRNTSSYDNTESVQNTVGSEKEETENKNEETSNYNSNLNNEINKICKYNLDQTDILLDDSNSERRRNSKFKIKNTNYYDNLMLQNKYTNSILYDDDDDKNNTETYTCTFKTEDQIRVPSQKKKYIYLYNKYDNATLDLNVHTYMSLGMSILCKYSLLYCGKYNHIPRDPYTPFKKPVSILSLDGGGILTISTLLVLNRLEAELRKEIGSDDIKLIDCFDMVCGTSAGGLISLALLREIDLQDVSNMWPSTIKKVFEGNRNIISGIFFEGYDVNNVKDVFLERMGNKFMSSYKKFYCFVTATDVKHKPYKLFLIRNYTHKYNSINAESYDGINKVPLWLAAWATASAPTYLKGPSAEDIKKLGINIKPEIHLVDGALKASNPALIALEECARLNNKNLSTFIKEDLDTLVSIGTGQVPTKLTQSGASSKSASTFEILINSTHLLTRANDTHREVLQRLADRENTYFRFNVPHIGDIEIDSQDVRDFDLISKATQDYLFDEKFYEIKRLAHKLANNYIRSKYL
Function: Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids such as phosphatidylcholine . Involved in gametogenesis; however, it is not clear whether it is involved in gametocytes development in host erythrocytes or in gametocyte activation in the mosquito midgut . Involved in gametocyte development in host erythrocytes; however, not involved in gametocytes activation including male gamete exflagellation . Involved in the rounding up of gametocytes following activation in the mosquito midgut; however, not required for gametocyte development in host erythrocytes . Required for exflagellation of activated male gametocytes . Involved in gametocytes egress from host erythrocytes by promoting the relocalization of perforin-like protein PLP2-containing vesicles to the periphery of gametocytes; PLP2 secretion is required for permeabilization of the erythrocyte membrane and thus, promotes gametocyte egress . Dispensable for asexual blood stage development . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) Sequence Mass (Da): 78305 Sequence Length: 679 Subcellular Location: Cytoplasm EC: 3.1.1.4
Q9LJ64
MTRRTMEKPFGCFLLLFCFTISIFFYSAAALTDEEASFLTRRQLLALSENGDLPDDIEYEVDLDLKFANNRLKRAYIALQAWKKAFYSDPFNTAANWVGPDVCSYKGVFCAPALDDPSVLVVAGIDLNHADIAGYLPPELGLLTDVALFHVNSNRFCGVIPKSLSKLTLMYEFDVSNNRFVGPFPTVALSWPSLKFLDIRYNDFEGKLPPEIFDKDLDAIFLNNNRFESTIPETIGKSTASVVTFAHNKFSGCIPKTIGQMKNLNEIVFIGNNLSGCLPNEIGSLNNVTVFDASSNGFVGSLPSTLSGLANVEQMDFSYNKFTGFVTDNICKLPKLSNFTFSYNFFNGEAQSCVPGSSQEKQFDDTSNCLQNRPNQKSAKECLPVVSRPVDCSKDKCAGGGGGGSNPSPKPTPTPKAPEPKKEINPPNLEEPSKPKPEESPKPQQPSPKPETPSHEPSNPKEPKPESPKQESPKTEQPKPKPESPKQESPKQEAPKPEQPKPKPESPKQESSKQEPPKPEESPKPEPPKPEESPKPQPPKQETPKPEESPKPQPPKQETPKPEESPKPQPPKQETPKPEESPKPQPPKQEQPPKTEAPKMGSPPLESPVPNDPYDASPIKKRRPQPPSPSTEETKTTSPQSPPVHSPPPPPPVHSPPPPVFSPPPPMHSPPPPVYSPPPPVHSPPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVQSPPPPPVFSPPPPAPIYSPPPPPVHSPPPPVHSPPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPSPIYSPPPPVFSPPPKPVTPLPPATSPMANAPTPSSSESGEISTPVQAPTPDSEDIEAPSDSNHSPVFKSSPAPSPDSEPEVEAPVPSSEPEVEAPKQSEATPSSSPPSSNPSPDVTAPPSEDNDDGDNFILPPNIGHQYASPPPPMFPGY
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat. Sequence Mass (Da): 102823 Sequence Length: 956 Subcellular Location: Secreted
Q9XIB6
MERPFGCFFILLLISYTVVATFDDEPSFPENADLTKDLEQKCFSINKVDPNLKFENDRLKRAYIALQAWKKAIYSDPFKTTANWVGSDVCSYNGVYCAPALDDDSLTVVAGVDLNHADIAGHLPPELGLMTDLALFHINSNRFCGIIPKSLSKLALMYEFDVSNNRFVGQFPEVSLSWPSLKFLDLRYNEFEGSLPSEIFDKDLDAIFLNNNRFESVIPGTIGKSKASVVTFANNKFSGCIPKSIGNMKNLNEIVFTGNNLTGCFPNEIGLLNNVTVFDASKNGFVGSLPSTLSGLASVEQLDLSHNKLTGFVVDKFCKLPNLDSFKFSYNFFNGEAESCVPGRNNGKQFDDTNNCLQNRPSQKPAKQCLPVVSRPVDCSKDKCSGGSNGGSSPSPNPPRTSEPKPSKPEPVMPKPSDSSKPETPKTPEQPSPKPQPPKHESPKPEEPENKHELPKQKESPKPQPSKPEDSPKPEQPKPEESPKPEQPQIPEPTKPVSPPNEAQGPTPDDPYDASPVKNRRSPPPPKVEDTRVPPPQPPMPSPSPPSPIYSPPPPVHSPPPPVYSSPPPPHVYSPPPPVASPPPPSPPPPVHSPPPPPVFSPPPPVFSPPPPSPVYSPPPPSHSPPPPVYSPPPPTFSPPPTHNTNQPPMGAPTPTQAPTPSSETTQVPTPSSESDQSQILSPVQAPTPVQSSTPSSEPTQVPTPSSSESYQAPNLSPVQAPTPVQAPTTSSETSQVPTPSSESNQSPSQAPTPILEPVHAPTPNSKPVQSPTPSSEPVSSPEQSEEVEAPEPTPVNPSSVPSSSPSTDTSIPPPENNDDDDDGDFVLPPHIGFQYASPPPPMFQGY
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat. Sequence Mass (Da): 90990 Sequence Length: 847 Subcellular Location: Secreted
Q9XIL9
MPHIYKQPLGIFQGFVPTLTDAEVSFIAQRQLLTLPENGELPDDIEYEVDLKVTFANHRLKRAYIALQAWKKAVYSDPFNTTGNWHGPHVCGYTGVFCAPALDDPDVAVVAGVDLNGADIAGHLPAELGLMTDVAMFHLNSNRFCGIIPKSFEKLSLMHEFDVSNNRFVGPFPSVVLSWPAVKFIDVRYNDFEGQVPPELFKKDLDAIFLNNNRFTSTIPDSLGESSASVVTFAHNKFSGCIPRSIGNMKNLNEIIFKDNSLGGCFPSEIGKLANVNVFDASMNSFTGVLPPSFVGLTSMEEFDISGNKLTGFIPENICKLPKLVNLTYAYNYFNGQGDSCVPGSQKQIALDDTRNCLPDRPKQRSAKECAVVISRPVDCSKDKCAGGSSQATPSKSPSPVPTRPVHKPQPPKESPQPNDPYNQSPVKFRRSPPPPQQPHHHVVHSPPPASSPPTSPPVHSTPSPVHKPQPPKESPQPNDPYDQSPVKFRRSPPPPPVHSPPPPSPIHSPPPPPVYSPPPPPPVYSPPPPPPVYSPPPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVYSPPPPPVHSPPPPVHSPPPPVHSPPPPVYSPPPPPPVHSPPPPVFSPPPPVHSPPPPVYSPPPPVYSPPPPPVKSPPPPPVYSPPLLPPKMSSPPTQTPVNSPPPRTPSQTVEAPPPSEEFIIPPFIGHQYASPPPPMFQGY
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat. Sequence Mass (Da): 78370 Sequence Length: 727 Subcellular Location: Secreted
O81765
MPFYKQPWVFSKVFVLAMAKPPSFGCCFFLLFFSFLSSSFVSFALTDTEAAFIVQRQLLTLPDNGELPDDIEYEVDLKATFANTRLKRAYIALQAWKKAIFSDPFNTTGNWHGPHVCGYTGVVCAPALDDSDVTVVAGVDLNGADIAGHLPAELGLMTDVAMFHLNSNRFCGIIPKSFEKLKLMHEFDVSNNRFVGPFPNVVLSWPDVKYFDLRFNDFEGQVPPELFKKELDAIFLNDNRFTSVIPESLGESPASVVTFANNKFTGCIPKSIGNMKNLNEIVFMDNDLGGCFPSEIGKLSNVTVFDASKNSFIGRLPTSFVGLTSVEEIDISGNKLTGLVPHNICQLPNLVNLTYSYNYFSGQGGSCVPGGSRKEIALDDTRNCLASRPEQRSAQECAVVINRPVDCSKDKCAGGSSTPSKPSPVHKPTPVPTTPVHKPTPVPTTPVQKPSPVPTTPVQKPSPVPTTPVHEPSPVLATPVDKPSPVPSRPVQKPQPPKESPQPDDPYDQSPVTKRRSPPPAPVNSPPPPVYSPPPPPPPVHSPPPPVHSPPPPPVYSPPPPPPPVHSPPPPVFSPPPPVYSPPPPVHSPPPPVHSPPPPAPVHSPPPPVHSPPPPPPVYSPPPPVFSPPPSQSPPVVYSPPPRPPKINSPPVQSPPPAPVEKKETPPAHAPAPSDDEFIIPPFIGHQYASPPPPMFAGY
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat. Sequence Mass (Da): 75248 Sequence Length: 699 Subcellular Location: Secreted
C0HLD6
FLSLIPKIAGGIASLVKDL
Function: The amidated Phylloseptin-1.2TR has weak antimicrobial activity against Gram-negative bacterium E.coli ATCC 25922 (MIC=100 uM), Gram-positive bacterium S.epidermidis ATCC 12228 (MIC=100 uM) and against fungus C.albicans ATCC 24433 (MIC=100 uM) . Has an anti-inflammatory effect, since it inhibits the production of the pro-inflammatory cytokines TNF-alpha and IL-1 beta, and induces the production of the anti-inflammatory cytokine IL-10 . Has an activity of stimulation of insulin release, which may protect the species from being eaten by predators by causing fatal hypoglycemia . Is cytotoxic to cancer line cells . Shows moderate hemolysis on mouse erythrocytes (LC(50)=75 uM) . PTM: Phylloseptin-1.2TR is amidated, whereas Phylloseptin-1.3TR is the name given to the non-amidated form. Sequence Mass (Da): 1955 Sequence Length: 19 Subcellular Location: Secreted
O15162
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
Cofactor: Magnesium. Can also use zinc with lower efficiency. Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface . Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A . Negatively regulates FcR-mediated phagocytosis in differentiated macrophages . May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes . Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions . Mediates also the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) PTM: Phosphorylation at Thr-161 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis . Phosphorylated by OXSR1 in the presence of RELT. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 35049 Sequence Length: 318 Domain: The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. Subcellular Location: Cell membrane
Q9JJ00
MENHSKQTEAPHPGTYMPAGYPPPYPPAAFQGPSDHAAYPIPQAGYQGPPGPYPGPQPGYPVPPGGYAGGGPSGFPVQNQPAYNHPGGPGGTPWMPAPPPPLNCPPGLEYLAQIDQLLVHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAVEDTDCCTRNCCGASRPFTLRILDNLGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGVPVGYVTQTWHPCLPKFTLQNEKKQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKISKQWSGFVREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEEQRSGAWQ
Cofactor: Magnesium. Can also use zinc with lower efficiency. Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface . Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 . Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages . May contribute to cytokine-regulated cell proliferation and differentiation . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) PTM: Phosphorylation at Thr-170 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis (By similarity). Phosphorylated by OXSR1 in the presence of RELT (By similarity). Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 35914 Sequence Length: 328 Domain: The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. Subcellular Location: Cell membrane
B3PEU9
MSATIRIAVDAMSGDLGPRVAIDAAQNFLQCHSDLEITLVGDESQLQQAHSLTGKNSRLHYLHAPDVVTMADDPLSALRHKKNSSMWKSLELLCLDRADACVSAGNTGALLAMARHQIKTLPGIERPAICKSMPVRSGVTYLLDLGANIDVGPELLHQFALMGAALARAAGVANPRVSLLNIGTEEYKGTQVLQQAQVLLQSDNSFTYSGFVEANRIFNGDVDVIVCDGFHGNVALKASEGVAQFIADKIAVEFKRHVFSRVMAFLAWPTLRRLKLQLNPARYNGASFLGLQKPVIKSHGNANEQAFIHALEVALQQVQERVPQRILEQISLH
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 36260 Sequence Length: 333 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q9PLB1
MKVRLGVDMMGGDHDPLVVWEALEEVLLSLDGQPVEFSVFATPDVHQQLTHSPLSRSVQMIASESFVSMEDSVLAAVRKKRSSMALGLDSLQRGELDGFISAGNTAALVTLARAKIPMIPAVPRPALLVSVPTLSGFAVILDVGATVAVNPEEMVGFARMGLAYRQSLSSSDQSFTLGLLNIGSEERKGTDSHKHTFRMLRDVFGSAFLGNVESGDVFSGKVDIVVTDGFTGNVFLKTAEGLFDFLRHILGDHLEKTIKTRFDYTIYPGSIISGLSRLVIKCHGKSRETALFGGISGAVDLARSNVCGRIAAKFGLEEA
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 34245 Sequence Length: 319 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q9Z6U6
MEVQIGIDLMGGDHSPLVVWQVLVDVLKSQSSTIPFAFTLFASEEIRKQIQEEFISDLPQEKFPKIISAENFVAMEDSPLAAIRKKSSSMALGLDYLQEDKLDAFISTGNTGALVTLARAKIPLFPAVSRPALLVCVPTMRGHAVILDVGANISVKPEEMVGFARMGLAYRQCLGDSKIPTIGLLNIGSEERKGTEAHRQTFRMLRETFGEAFLGNIESGAVFDGAADIVVTDGFTGNIFLKTAEGVFEFLQRILGDKLEADIQRRLDYTFYPGSVVCGLSKLVIKCHGKACGSSLFHGILGSINLAQARLCKRILSNLI
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 34857 Sequence Length: 320 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q8KAP3
MGGDNAPACVVEGVIDALRESGNRFEILLIGQEEKVAPLLQQYDTGALKLRFVHAPEVITMEDVPATAVKAKQESSLVRGLKLCKAKDADAFVSAGNTGAMMAASLFVLGRIPGVLRPTIYAYFPRLGEGLTNLVDVGANVDCKPENLVQFAEMLTIYQRYAAKIEQPVVGLLNIGEEEGKGPDYLKQAWKMLQKAHEEQKINFIGNIEGHDILAGKATIVVCDGLVGNTILKFGESIPHFLGAIFKPALEKLVKEGKLDQNSAVLAGQTFKGIFEPFDVEKFGGVPFLGVDGISIVGHGRSSARAIKNMIYMAEHMIEQRVNERIAKMLA
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 35880 Sequence Length: 331 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q1QX56
MTVRIAIDAMGGDLGPRATVLGSLQALSMHPDLEIQMYGPREALEDELETLPKRLSGYRSRLVLHDAPRVISQAMRVASALREAEGSSMLGALSGVREGRAQACVSAGNTGALMALGRRELGTISGISRPAISTAVPTQDGGRCYLLDLGANVDVQTRHLVDFARMGAVMARVVDEVAVPRVALLNIGVEANKGVPSVRDADRCLREDASRRIGDGTFDYIGYLEGDGIFSGAADVVVCDGFVGNAVLKASEGLATMLLTRLQETFEAHLTTRMVRAMARPALLRLKRRLDPVRYNGASLLGLAGIAVKSHGGADAKGFAYAVSRAVREIDMDLPAHLARALSDEGAAKPSTHSAAAVGGRVDSGLASDARPDDSHPQR
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 39986 Sequence Length: 379 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q7NSK6
MTITVAVDAMGGDVGLKVTVPASIQFLQDHPDTHLILVGDQPALEAELALHDGAVRERILIQHATQVVGMDEAPQLALKNKKDSSMRVAINLVKEGKAQAAVSAGNTGALMATARFVLKTIPGIDRPAIAKLLPNVKGTSCVLDLGANVDCTPEQLLQFGIMGSELMACLQGKANPSVGLLNIGSEDIKGNDNIKKTAELLRQSELHFYGNVEGDDICKGTTDVVVCDGFTGNVALKTAEGLAHMFAVFLREEFGRSWWTRLCALAALPVLALFKKRIDPRRYNGASLLGLRGIVVKSHGSADVTGFRYALAQACEEAGSDVIAHIADRVAKQLDNLKQSEAEAN
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 36730 Sequence Length: 345 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
B5E8U7
MRVAVDVMGGDNAPHVEVEGAVAAAREFGVPVTLVGDAEKVRAELARYDCKGLDIEVWHASEVVGMHDSASDAVRKKKDSSIRIAFELVKGGEAVAVVSAGNSGATMAAGMFVLKRMKGIDRAAIAQLFPTVSGKTLVLDVGGNVDCKPIHLVQFAVMGEVYARFVMGVDNPKVGLLSNGEEASKGNELTRETSALLREKPINYIGYVEGRDIFNGSVDVVVCDGFVGNVALKLSEGLAEAVGKMLKAEIKSSFLSQIGYLLSRKAFNNFKKTVDYAEYGGAPLLGINGVGMICHGGSNPKAIKNAIRFAHEYALKGVNGRMAEKLNESFPGDAREREGAPAPDAGTERVAS
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 37233 Sequence Length: 352 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q31HR8
MSIKIAIDAMGGDHGIKVTVPASLEALSKFSDISIVLVGNQPLIEAELANHKYDKNRLSVEHAEQIVEMDDLPSKALRNKRKSSMRIALNLVKDDVAQACVSAGNTGALMAVSKFVLKTLPGIDRPAICTQMPTMKGHVHVLDLGANVGADGQSLAQFAVMGSVLAQAVDSNSRPRVGLLNIGEEEIKGHQRIKDANEILKSSDAINYVGYVEGDEIFKGDVDVVSCDGFDGNVALKASEGVAKMISFYLRAAFNKNLLTKLAGLVVYPVLKAFKAKVDPRRYNGASFLGLRKIVIKSHGGADVFSFYHAIAEARLEVNKNVPELIATEVKAILETH
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 36262 Sequence Length: 337 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q5QZ38
MPELNIAIDAMGGDNGPSIVIEALEKAVHRYPDVKFTVVGHEQQLTPLLDKFNLSSHPSINLVHAEQVIEMDDKPGQSLRSKPESSMRVALQSLTDGNCQAMVSGGNTGALMTNAYFTLKTLPGVLRPALMTALPNQTGGKSYLLDLGANASCDSETLFQFGVMGAVAAEYLSGVPAPKISLLNMGEEDIKGNDVVRNAAARLAQCEQLNYIGFIEGNHLFSGRADVVVCDGFVGNVALKSCEGLATFIIDQMRDTLNSHWLYRFFFRFLQKRTHKSWDRLKPDHYNGASLIGLRHVVIKSHGSASAGAFYSAIQQAVAEAHEQLPERIKHRVEAVLSEQL
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 37164 Sequence Length: 341 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q1IJ05
MPITIAVDAMGSDKAPTPEIEGALQAIRHFDVRVILVGKQDVLREHLGAHAHPGRLPIEIVHASEVISMHDKAALAVRSKRDSSMRVGLRLVREGKADAFVTAGNTGAAMATAKMVLGALPGVDRPALAAVFPTEKRTAAILLDVGANVDCKPQNLQQFAIMGEVYFRTVFAGKSPHARSPRVGILSIGEEETKGNELTREAYKLVKTLPLNFVGNVEGRDLFNGNVDVLVCDGFVGNVALKISEGLVKTVREMLKESLQQTIARQVGFLLSRQAFVDFKKRLDYSEYGGAPLLGLKGAAFVGHGSSNANAIKNAIRVAAEYVEHRVNEAIAREIAAASEKLGNHHSSAKKEEGEEARA
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 38552 Sequence Length: 359 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q8DWL9
MKKIAVDAMGGDNAPQAIVEGVNQALADFSDIEIQLYGDEAKIKTYLKANDRVSIIHTDEKINSDDEPVKAIRKKKQASMVLGAQAVKDGKADAVLSAGNTGALLAAGLLVVGRIKNIDRPGLMSSLPTIDGKGFNMLDLGANAENTAHHLHQYAILGSFYAKNVRGVAHPRIGLLNNGTETTKGDPLRKETFALLAADETLNFIGNVEARDLMNSVADVVVTDGFTGNAVLKSIEGTALGIMEQLKTSIKQAGLRAKLGALLLKNSLYDLKDSLDYSGAGGAVLFGLKAPVVKCHGSSDAKSVYYTIKQIRIMLETDVVGQLVEEFSNRGD
Function: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Catalytic Activity: a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP] Sequence Mass (Da): 35294 Sequence Length: 332 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cytoplasm EC: 2.3.1.274
Q39DI4
MQILLAALVAYLIGSVSFAVVVSGAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWIAVWLARHLGLPDVAVAWVAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPVFDVFLFGTGHNPVAWAVLAMSVLLVWRHRGNISKLLAGQESRIGDKKKAAADGGAQDGGKA
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 22111 Sequence Length: 212 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q3JVC1
MQILLATVAAYLIGSVSFAVVVSAAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWLAVWLVKRFGIGGEIGVALAAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPIFDVFLFGTHDNPVAWAVLAMSVLLIWRHRSNISKLLAGEESRIGQKKKTGA
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21385 Sequence Length: 203 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q2T0L4
MQILLATVAAYLIGSVSFAVVVSAAMGLADPRSYGSKNPGATNVLRGGNKKAAILTLVGDAFKGWLAVWLVKHFGIGGEIGVALAAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPALGLATALTWLIIAFFFRYSSLAALVAAVFAPVFDVFLFGTRNNPVAWAVIAMSALLIWRHRSNISKLLAGEESRIGQKKTDA
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21228 Sequence Length: 202 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q4FLQ2
MEYLIVALSSYLLGSIPFGFILTKIFLKKDIRDIGSGNIGATNALRTGNKTLGYATLLLDITKAVLPVLYVKFNYPDYIFIASLSAFLGHVFPIWLKFKGGKGVATYVGILFSINIFLGLVFIISWAVTFLISKYSSLSSLVGSLMVPMYLIVFENYNSIFFIIMFVLIFYTHRENVKRLKNKEETKTKIY
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21605 Sequence Length: 191 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
A3PEG1
MNILIIFASYLLGSLPTGFLIGKYLKNIDLRTIGSGSTGATNVLRNVGKWPALFVFIIDLGKGLIAVKIAQYYTDQGLIEVIAGISAISGHIWPIWLRGKGGKAVATGLGMFLALSWKVGLASLGFFLIVLTKTKYVSLSSISAAILLPIFMFFYLGKFMHSYFFISLIVALLVIWKHRTNITRLLKGEESKINQTQ
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21647 Sequence Length: 197 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
A2BY34
MTIIIIVLSYFLGSIPTGFLFGKFLKNIDLRLIGSGSTGATNVLRNVGKWPAFFVFIIDVGKGLLAVKLSQSYTNQHLFEVLAGISAVSGHIWPIWLKGKGGKAVATGLGMFIALSWKVGFASLGIFLIILSKSKIVSLSSILAAFFLPLFMFLDIGVTNHPYFLISLVVSILVILKHRTNIRRLIKGEESKINSLNK
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21624 Sequence Length: 198 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q7V5Y3
MFNSLFGNLLSLVMGYLLGSLPSGYLAAHWLAGIDLREKGSGSTGATNVLRQVGKGPALAVFLIDVGKGTTAVLVARALELDDGWQVAAGLAALAGHIWPVWLGWKGGKAVATGLGMLLGISWPVGLACFGIFLTVLSFSRIVSLSSIIAALSLPLLMILRFQGNSPPAYLAVAFAAMAMVVWRHRSNLQRLLAGTEPRLGQSS
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21370 Sequence Length: 204 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q7V0D9
MHILIISISYFLGSLPTGFLFGKFLKNIDLRLTGSGSTGATNVLRNVGKWPAFFVFIIDVGKGLIAVKIAQHYTNQNLFEVLAGIAAISGHIWPIWLKGKGGKAVATGLGMFIALSWKIGFASLGIFLIILAKSKIVSLSSISAAIFLPFLMFLDIGSTNHPYFFISLVVSILVIWKHRTNIRRLLKGEELKINDINK
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21732 Sequence Length: 198 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q46JD9
MNLLILFFGYLFGSFPSGYLAGRIAKGIDIRSLGSGSTGATNVLRHIGKRAAITVFLLDVFKGVLSILLAKYLLLNDSWQVAVGLSTLIGHIWPVWLNWKGGKAVATGLGIFLGLSWQVGLATLGVFIIMITLFRIVSLASVSASLALPLIMFLSFSGSNLSLPFLIVSLLAMILVIWRHRENIVRLIRGKEPRIGQP
Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21504 Sequence Length: 198 Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Cell inner membrane
Q91VC4
MGLSMDRSPYARTGDQQRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADSLYSQVVGLSASQANLSKQLNISLLVKETVMQQLLTTRREMERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEVNKTCEALLFKLGEKVKTLEMEVAKEKAVCSKDKESLLAGKRQTEEQLEACGKARERQQQEQQVTEENLRKVQSLCIPLDQEKFQADVLSAWRDSLIYRTLETLPYHYQLMPEYASLRRTCESLPGIMTTKIEELARGLRAGIERVTRENAELRRQKLELERAAQAAQEARARAGTEAQARETQLRAECARQTQLALEEKAALRAQRDNLERELEARKRELEQLRTEVDVRISALDTCVKAKSLPAVPPRVSGPPPNPPPIDPASLEEFKKRILESQRLPVVNPAAQPSG
Function: Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 49933 Sequence Length: 438 Subcellular Location: Cell membrane
O04499
MATSSAWKLDDHPKLPKGKTIAVIVLDGWGESAPDQYNCIHNAPTPAMDSLKHGAPDTWTLIKAHGTAVGLPSEDDMGNSEVGHNALGAGRIFAQGAKLCDQALASGKIFEGEGFKYVSESFETNTLHLVGLLSDGGVHSRLDQLQLLIKGSAERGAKRIRVHILTDGRDVLDGSSVGFVETLEADLVALRENGVDAQIASGGGRMYVTLDRYENDWEVVKRGWDAQVLGEAPHKFKNAVEAVKTLRKEPGANDQYLPPFVIVDESGKAVGPIVDGDAVVTFNFRADRMVMHAKALEYEDFDKFDRVRYPKIRYAGMLQYDGELKLPSRYLVSPPEIDRTSGEYLTHNGVSTFACSETVKFGHVTFFWNGNRSGYFNEKLEEYVEIPSDSGISFNVQPKMKALEIGEKARDAILSGKFDQVRVNIPNGDMVGHTGDIEATVVACEAADLAVKMIFDAIEQVKGIYVVTADHGNAEDMVKRDKSGKPALDKEGKLQILTSHTLKPVPIAIGGPGLAQGVRFRKDLETPGLANVAATVMNLHGFVAPSDYEPTLIEVVE
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA) . Required for guard cell function (e.g. blue light-, abscisic acid- (ABA), and low CO(2)-regulated stomatal movements) and fertility (e.g. pollen grains production) . Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 60580 Sequence Length: 557 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.12
P00950
MPKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNRSWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQKGDERYKYVDPNVLPETESLALVIDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKPSKPSYYLDPEAAAAGAAAVANQGKK
Function: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also Catalyzes the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Location Topology: Peripheral membrane protein Sequence Mass (Da): 27609 Sequence Length: 247 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.11
Q9M9K1
MGSSGDVNWKLADHPKLPKGKTIGLIVLDGWGESDPDQYNCIHKAPTPAMDSLKDGKPDTWRLIKAHGTAVGLPSEDDMGNSEVGHNALGAGRIYAQGAKLVDLALASGKIYEDEGFKYISQSFEKGTVHLIGLLSDGGVHSRLDQVQLLLKGFAERGAKRIRVHILTDGRDVLDGSSVGFVETLEADLAALRAKGVDAQVASGGGRMYVTMDRYENDWSVVKRGWDAQVLGEAPHKFKSALEAVKTLRAEPGANDQYLPSFVIVDDNGKAVGPIVDGDAVVTFNFRADRMVMHAKALEYKDFDKFDRVRVPDIRYAGMLQYDGELKLPSRYLVSPPLIDRTSGEYLAHNGVRTFACSETVKFGHVTFFWNGNRSGYFNEKLEEYVEIPSDSGISFNVQPKMKALEIAEKARDAILSGKFDQVRVNLPNGDMVGHTGDIEATVVACEAADRAVRTILDAIEQVGGIYVVTADHGNAEDMVKRDKSGKPALDKEGNLQILTSHTLKPVPIAIGGPGLSAGVRFRQDIETPGLANVAATVMNLHGFVAPSDYETSLIEVVEK
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA) . Required for guard cell function (e.g. blue light-, abscisic acid- (ABA), and low CO(2)-regulated stomatal movements) and fertility (e.g. pollen grains production) . Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 60764 Sequence Length: 560 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.12
Q12008
MTASTPSNVMTLFLLRHGQSELNHENIFCGWIDAKLTEKGKEQARHSAELIEQYCKANNLRLPQIGYTSRLIRTQQTIETMCEEFKLKPQLQVVYDFNKIKLGDEFGSDDKDNMKIPILQTWRLNERHYGSWQGQRKPNVLKEYGKDKYMFIRRDYEGKPPPVDLDREMIQQENEKGSSTGYEFKEPNRQIKYELECSNHDIVLPDSESLREVVYRLNPFLQNVILKLANQYDESSCLIVGHGSSVRSLLKILEGISDDDIKNVDIPNGIPLVVELDKNNGLKFIRKFYLDPESAKINAEKVRNEGFIKNP
Function: Could be non-functional. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 36073 Sequence Length: 311 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.11
P07738
MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK
Function: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. PTM: Glycation of Lys-159 in diabetic patients inactivates the enzyme. Catalytic Activity: (2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+) Sequence Mass (Da): 30005 Sequence Length: 259 EC: 5.4.2.4
P30792
MGSSGFSWTLPDHPKLPKGKSVAVVVLDGWGEANPDQYNCIHVAQTPVMDSLKNGAPEKWRLVKAHGTAVGLPSDDDMGNSEVGHNALGAGRIFAQGAKLVDQALASGKIYDGDGFNYIKESFESGTLHLIGLLSDGGVHSRLDQLQLLLKGVSERGAKKIRVHILTDGRDVLDGSSIGFVETLENDLLELRAKGVDAQIASGGGRMYVTMDRYENDWDVVKRGWDAQVLGEAPYKFKSALEAVKTLRAQPKANDQYLPPFVIVDDSGNAVGPVLDGDAVVTINFRADRMVMLAKALEYADFDNFDRVRVPKIRYAGMLQYDGELKLPSRYLVSPPEIDRTSGEYLVKNGIRTFACSETVKFGHVTFFWNGNRSGYFDATKEEYVEVPSDSGITFNVAPNMKALEIAEKARDALLSGKFDQVRVNLPNGDMVGHTGDIEATVVACKAADEAVKIILDAVEQVGGIYLVTADHGNAEDMVKRNKSGKPLLDKNDRIQILTSHTLQPVPVAIGGPGLHPGVKFRNDIQTPGLANVAATVMNLHGFEAPADYEQTLIEVADN
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. PTM: The N-terminus is blocked. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 60620 Sequence Length: 559 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.12
O24246
LPTEDDMGNSEVGHNALGAGRIFAQGAKLVDSALETGKLYEGEGFKYIKESFPTNTLHLIGLLSDGGVHSRLDQLLLLVKGASERGAKRIRVHILTDGRDVLDGSSVGFAETLENYLAQLREKGVDAQIASGGGRMYVTMDRYENDWGVVKRGWDAQVLGEAPHKFKNAVEAIKTLRQEPNTSDQYLPPFVIVDENGKPVGPIVDGDAVVTFNFRADRMVMIAKALEYADFDKFDRVRFPKIRYAGMLQYDGELKLPSKYLVEPPEIDRTSGEYLTYNGVRTFACSETVKFGHVTFFWNGNRSGYFNPQMEEYVEIPSDSGITFNVQPKMKAVEIAEKGRGAILSKKFEQVRVNLPNSDMVGHTSSIEATVVACKAADEAVKIIIDAIEQVGGIYVVTADHGNAEDMVKRNKKGQPLLDKNGNIQILTSHTLQPVPIAIGGPGLAPGVQFRKDVPNGGLANVAATVMNLHGFEAPADYETTLIEVVDN
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 53395 Sequence Length: 488 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.12
P35494
MGSSGDAWKLKDHPKLPKGKTVAVIVLDGWGEAKPNEFNAIHVAETPVMYSLKNGAPEKWRLIKAHGNAVGLPTEDDMGNSEVGHNALGAGRIFAQGAKLVDLALASGKIYEGEGFKYVKECFEKGTLHLIGLLSDGGVHSRLDQVQLLLKGAAKHGAKRIRVHALTDGRDVLDGSSVGFMETLENSLAQLREKGIDAQVASGGGRMYVTMDRYENDWDVVKRGWDAQVLGEAPHKFKDPVEAVKKLRQEPNANDQYLAPFVIVDDNGKPVAAILDGDAVVTFNFRADRMVMLAKALEYENFDKFDRVRVPKIRYAGMLQYHGELQLPSHYLVSPPEIARHSGEYLVRNGVRTFACSETVKFGHVTFFWNGNRSGYFNEKLEEYVEIPSDSGITFNVKPKMKALEIAERTRDAILSGKFDQVRVNLPNGDMVGHTGDIKATIEACKSADEAVKMILEAIEQVGGIYLVTADHGNAEDMVKRNKKGEPALDKNGNIQILTSHTCEPVPIAIGGPGLAPGVRFRQDLPTGGLANVAATFMNLHGSEAPSDYEPSLIEVVDN
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequence Mass (Da): 61067 Sequence Length: 559 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Subcellular Location: Cytoplasm EC: 5.4.2.12
F1NQJ3
MEEAAPCSEPAKTIKRIDRESVHRICSGQVVLSLGTAVKELVENSLDAGATNIDVRLKDHGAELIEVSDNGGGVEEENFEGLTLKHYTSKIQDFSDLIHVETFGFRGEALSSLCALSDVTISTCHKSAKVGTRLVFDHNGKITQKAPYPRQQGTTVSIQQLFHTLPVRHKEFQRNIKKEYAKMVQILQAYCIISKGVRINCTNQVGQGKKSPVVSTTGGPNLKENIGAVFGKKQLQSLIPFVQLPPNEAVCEEYGLKSTDLPEKLYSITGFISRCDHGVGRSTTDRQFFFINQRPCDPAKVVKLVNEVYHLYNKHQYPFIVLNICVDSECVDINVTPDKRQILLQEEKLLLAILKTSLIEMFGSDVNKLNVNQNLLDIVGNVKAPPGDAEKPWVEMSHHSETENPSSEGKRVMTLSRLRESFSLHQTESYFQSPKKVKQRHSSSKQLSLDTILSTVRTQKAVLSEDSESCHEMKSKMPVPRKYLRKVDDIDSGFCSTSESDAGYNTPEAGSCVISESVNNPIEEEFCSSEEQHQNEYLKTVGHSEKSLECDIQVLGTEHKLNRVNDCNNQTNLPQEATNSLPRVRRFKNEADDFKAGIHPKVENTRNYMPCVDVLVEVKKKTVPLEFSMKALAERVRKIVQQQQKCTETQNYRRFRAKISPGENKVAEDELRKEISKEMFAKMEIIGQFNLGFIIAKLNSDLFIIDQHATDEKYNFEMLQQHTVLQGQKLIAPQNLNLTAVNETVLIENLEIFRKNGFDFVINENAPVTQRVKLISLPTSKNWTFGPQDIDELIFMLSDCPGVMCRPSRVRQMFASRACRKSVMIGTALNVQEMKKLVTHMGEIEHPWNCPHGRPTMRHIASLDLIASE
Function: Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity). Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Mass (Da): 97996 Sequence Length: 869 Subcellular Location: Nucleus EC: 3.1.-.-
P54278
MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN
Function: Component of the post-replicative DNA mismatch repair system (MMR) . Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair . Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Mass (Da): 95797 Sequence Length: 862 Subcellular Location: Nucleus EC: 3.1.-.-
Q8RWB7
MAGFTMSLNLLLLVAMVATNILSLYHLSSTTNFFQSTVKSSQSSVPTVPDHLLRQLHTIRAAINHLTTHQPDKSTSTSTSRAAVSSSSSSTAPKELLIYSKLSPIASACHNYPDLLHEYMNYTPFSLCPSDTDLVEKLILRGCHPLPRRRCFSRTPRNPSDSKPESNVLWSYYSCKSFDCLITKFSDLGFDLSLEKSKSQFSAYKSELDLPISQLLQIAKSANSVLRLGIDVGGGTGSFAAAMKARNVTVLTTTMNFNAPYSEAVAMRGLVPLHVPLQQRLPVFDGVVDLVRCGRAVNRWIPVTVMEFFFFDLDRILRGGGYLWLDRFFSKKVDLENVYAPMIGKLGYKKVKWAVANKADSKHGEVFLTALLQKPVAR
Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 41956 Sequence Length: 378 Subcellular Location: Golgi apparatus membrane EC: 2.1.1.-
P40999
MLSTKRLRVLELYSGIGGMHYALNLANIPADIVCAIDINPQANEIYNLNHGKLAKHMDISTLTAKDFDAFDCKLWTMSPSCQPFTRIGNRKDILDPRSQAFLNILNVLPHVNNLPEYILIENVQGFEESKAAEECRKVLRNCGYNLIEGILSPNQFNIPNSRSRWYGLARLNFKGEWSIDDVFQFSEVAQKEGEVKRIRDYLEIERDWSSYMVLESVLNKWGHQFDIVKPDSSSCCCFTRGYTHLVQGAGSILQMSDHENTHEQFERNRMALQLRYFTAREVARLMGFPESLEWSKSNVTEKCMYRLLGNSINVKVVSYLISLLLEPLNF
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Can also methylate cytosine 38 in tRNA(Glu), albeit to a lower level, but not tRNA(Lys). Pmt1-dependent tRNA methylation is induced by nitrogen limitation and depends on the nutrient-sensing protein kinase sck2. Does not have DNA-methylation activity. Catalytic Activity: cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 37976 Sequence Length: 330 Subcellular Location: Cytoplasm EC: 2.1.1.204
Q23552
MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILASLPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDAVGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKAKSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQVHWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLPSNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFGWNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNEAEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH
Function: Catalyzes the first step in the synthesis of phosphocholine by converting phosphoethanolamine into phospho-monomethylethanolamine (N-methylethanolamine phosphate). Phosphocholine is a precursor for phosphatidylcholine, a major component in membranes and a precursor itself in the production of glycoconjugates secreted by parasitic nematodes to avoid host immune responses. Catalytic Activity: phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine Sequence Mass (Da): 55148 Sequence Length: 475 Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine. EC: 2.1.1.103
O74189
MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
Function: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentation and early phases of biofilm formation. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 99935 Sequence Length: 877 Pathway: Protein modification; protein glycosylation. Subcellular Location: Endoplasmic reticulum membrane EC: 2.4.1.109
O13898
MDKQSTFQDPKEKHRIQRDVKLSRPRKRFSFLDYVVVIFLTVVAFCVRAQRLMNPAKVVFEELRYYNYAVDYVNNKLLMDVYPPLGKLLFSLVAALTGNKYELNTLDEPGQQYPFTDVAYSMRLFTCLLGSLLVPLMYGTVYFPTKSKTAASLAALFVIFDNGLITMSRYIMIEIPALYFMSLTAFYWSVYEAQQKRPFSLRWHTSLLSTGVALGLALSTKLSAMFTFGWLLILAAFHLWNLLGDLSVPMYRIVKHLFSYIFYLIGVPITVYLAVFAVHSHIAYKASVADAFLPPEHRHALAGNRFDDQFADVAYGSLVTIRNAIPEHGYLHSSELLYPEGTEQQIISLVDEPNQNALWIIEHEHSQDNNRSNIELLKDGSVVRLRHVMTGRALHSHEHKPIVSNNDWQLEASAYGGFGFEGDANDLFRIQILEKKSKHATSNGTVETLNTKFRLIHVFANCELMSSHRRFPDWGDYQREVTCCRNCVERSTTWFIESNYHDGLPSDSRKITYRKPGFLESFVEHNKLMWLKDRKMGDGHVYESSALTWPLLLGPLRFFYEQHLQVFFMGNPFVWYSVISLVAFFVIVQIFCLARWNLGYNDFGPSAFHYNYNIGKFVVAWLLHWAPYILETDRVFLYHYLPALYFGIAALGVSWSFLGNAVFGNRTAYKALSVIIMALMFLVYRLYSPFTYMTTLTKSSCRALELKGSWNFHCNTYLDNLSDYKFSSDAGETYFEKAAPHPFVYSEDTAKKSEGDTPLNKNLNDYYPSWDQRVEAGYKLAAQQKAEQEAREAAEKAASEAAERSSSEAAASSSSESVAAASVEAERLAMEADEFNGASETVDGASVEAERSAMEAAALNNAAESTEVVGSSPESVASEQEENVAESAQARVE
Function: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell growth and septum formation. Shown to actively O-mannosylate wsc1. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 101335 Sequence Length: 893 Pathway: Protein modification; protein glycosylation. Subcellular Location: Endoplasmic reticulum membrane EC: 2.4.1.109
Q42963
MEVISTNTNGSTIFKNGAIPMNGHQNGTSEHLNGYQNGTSKHQNGHQNGTFEHRNGHQNGTSEQQNGTISHDNGNELLGSSDSIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPSIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPVNPIDKETTQVKSKLGPLKFYNSDIHKAAFILPSFARSMIES
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) . Methyltransferase that mediates the conversion of putrescine to N-methylputrescine . Promotes leaves ripening . Catalytic Activity: putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine Sequence Mass (Da): 41142 Sequence Length: 375 Pathway: Alkaloid biosynthesis; nicotine biosynthesis. EC: 2.1.1.53
P33775
MSEEKTYKRVEQDDPVPELDIKQGPVRPFIVTDPSAELASLRTMVTLKEKLLVACLAVFTAVIRLHGLAWPDSVVFDEVHFGGFASQYIRGTYFMDVHPPLAKMLYAGVASLGGFQGDFDFENIGDSFPSTTPYVLMRFFSASLGALTVILMYMTLRYSGVRMWVALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMYPANSLNAYKSLLATGIALGMASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSKSIFKVAFAKLAFLLGVPFALYLVFFYIHFQSLTLDGDGASFFSPEFRSTLKNNKIPQNVVADVGIGSIISLRHLSTMGGYLHSHSHNYPAGSEQQQSTLYPHMDANNDWLLELYNAPGESLTTFQNLTDGTKVRLFHTVTRCRLHSHDHKPPVSESSDWQKEVSCYGYSGFDGDANDDWVVEIDKKNSAPGVAQERVIALDTKFRLRHAMTGCYLFSHEVKLPAWGFEQQEVTCASSGRHDLTLWYVENNSNPLLPEDTKRISYKPASFISKFIESHKKMWHINKNLVEPHVYESQPTSWPFLLRGISYWGENNRNVYLLGNAIVWWAVTAFIGIFGLIVITELFSWQLGKPILKDSKVVNFHVQVIHYLLGFAVHYAPSFLMQRQMFLHHYLPAYYFGILALGHALDIIVSYVFRSKRQMGYAVVITFLAASVYFFKSFSPIIYGTPWTQELCQKSQWLSGWDYNCNTYFSSLEEYKNQTLTKRESQPAATSTVEEITIEGDGPSYEDLMNEDGKKIFKDTEGNELDPEVVKKMLEEEGANILKVEKRAVLE
Function: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT3 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export. Required for incorporation of proteins in the cell wall. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 92675 Sequence Length: 817 Domain: The large luminal loop 5 is essential for mannosyltransferase activity but not for PMT1-PMT2 complex formation. Pathway: Protein modification; protein glycosylation. Subcellular Location: Endoplasmic reticulum membrane EC: 2.4.1.109
B9DFI7
MALKSSSADGKTRSSVQIFIVFSLCCFFYILGAWQRSGFGKGDSIALEMTNSGADCNIVPSLNFETHHAGESSLVGASEAAKVKAFEPCDGRYTDYTPCQDQRRAMTFPRDSMIYRERHCAPENEKLHCLIPAPKGYVTPFSWPKSRDYVPYANAPYKALTVEKAIQNWIQYEGDVFRFPGGGTQFPQGADKYIDQLASVIPMENGTVRTALDTGCGVASWGAYLWSRNVRAMSFAPRDSHEAQVQFALERGVPAVIGVLGTIKLPYPTRAFDMAHCSRCLIPWGANDGMYLMEVDRVLRPGGYWILSGPPINWKVNYKAWQRPKEDLQEEQRKIEEAAKLLCWEKKYEHGEIAIWQKRVNDEACRSRQDDPRANFCKTDDTDDVWYKKMEACITPYPETSSSDEVAGGELQAFPDRLNAVPPRISSGSISGVTVDAYEDDNRQWKKHVKAYKRINSLLDTGRYRNIMDMNAGFGGFAAALESQKLWVMNVVPTIAEKNRLGVVYERGLIGIYHDWCEAFSTYPRTYDLIHANHLFSLYKNKCNADDILLEMDRILRPEGAVIIRDDVDTLIKVKRIIAGMRWDAKLVDHEDGPLVPEKVLIAVKQYWVTNSTSTH
Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 69623 Sequence Length: 616 Subcellular Location: Golgi apparatus membrane EC: 2.1.1.-
Q22993
MSSLSIPRQSLYYVNKVTEGRSVSNVQVVSPCQKQGQTYVTAFTPLTSNVQVHTSLEQLSTIRNADVLIFNNALSQIITNADLLTDFLKNATNATAIGGTVIIREDLKDCSDKRQVARLTDYFDVFRTTDSDGNNTGLDLYTVDQVEHSNYVEQNFLDFIFVFRKKVFAPTTDATITFRDFLDKTQYTNTGIDAYEWMFGVNFISPGGYDENLKIIKRFGDFKPGQTMLDIGVGIGGGARQVADEFGVHVHGIDLSSNMLAIALERLHEEKDSRVKYSITDALVYQFEDNSFDYVFSRDCIQHIPDTEKLFSRIYKALKPGGKVLITMYGKGYGEQSDKFKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENMTPRFKEILLEERGHLEQNEAEFMSKFTQRERDSLISGWTDKLGYIEKDNHNWNFFLAQKPFPK
Function: Catalyzes the last two methylation reactions in the synthesis of phosphocholine, by converting phospho-monomethylethanolamine (N-methylethanolamine phosphate) into phospho-dimethylethanolamine (N,N-dimethylethanolamine phosphate) and the latter into phosphocholine. Phosphocholine is a precursor for phosphatidylcholine, a major component in membranes and a precursor itself in the production of glycoconjugates secreted by parasitic nematodes to avoid host immune responses. Catalytic Activity: N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine Sequence Mass (Da): 49769 Sequence Length: 437 Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine. EC: 2.1.1.103
Q9C100
MSYEQLHAQSGQLRQRFPSKHSEIEDEVANEKEELKDATKSALGEVKTNKKYYILGYFLVPLLLTVIAGFVRVWKIADSNVVIWDEAHFGKFASYYLKHEFYFDVHPPLGKMLNAVAGKLVGYDGSFDFSSGATYPEDLNYKFMRLWNAAFGTLCIPLVYFTALNFNYSFLAATLCTLMVALDNHLATISRFILLDSMLLFFIISTFFCLSRYHVYHKAPFTFYWFKWLFLTGVCIGCVCSVKLVGLFITAVVGLYTVDELWCLLNDKRVTWKAYAGHWIARVCLLIFLPILIYAFTFWIQFAVLYRSGPGDAQMPSLFQARLEGSPLTKNPIDLMYGSKFTLKSRNPTGALLHSHVQTYPEGSEQQQVTGYHHKDGNNEWMFVPTHGVAYNYEENDPMNPILNGSVVRLIHPFTNRNLHTHKIPAPLNKRMYEVSGYGLGDVGDEKDYWIVNILYDTAHRDAYNVRSLSTVFQLYNPVVGCYLSSSSSSLPSWGFGQIEMYCDPDPDPSNTDTQWNVEEHINPRLPEGSINDYPSSFWSDFLHLNRAMLRANNGLIPDEDKLDALRSEAYQWPFLLATLRMCGWGDNQIKYLLVGNPVAYWFATSSLIVFALFVVGAVLAWRRRVLRWSQEACDTFHYAGIYPFLGWFFNYLPYYIMGRVLYVHHYEPSYALSTFTAAFVVDWFTKKMPKIVRVVVFISLYAIIAGVFIYFKDVTFGMHGPASDFHRLRWLNSWNVHD
Function: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85037 Sequence Length: 739 Pathway: Protein modification; protein glycosylation. Subcellular Location: Endoplasmic reticulum membrane EC: 2.4.1.109
Q59Q38
MTPPIKSPSSSSVDYGKLSEQLMIAYTKDVLQRNLQKFHGEQHRQQFKQLLNQPVIKSIHSLSGIIVRYRHNNSELDKALDTIDLPKIFERLEIREKTNKDKNLDYDDLLVLELLNYFKNDFFKWVNSPDCPSCGSNEDVQGLGAINPSSSKTISQSQAIIDQVSVIEVHECKKCKQKIEFPRINNPVTLLTTRRGRCGEWVNCFMLILQALIGGGDDDSDRIRYVWNQEDHVWCEYYSLSSKRWIHLDPCEGVYDEPLLYCNNWGKRMSYVIGFNYNYMIDLSDKYIVPEKQIPKNSIVNVQNVNFVISYSNGINQLKHFKRIEQQQQQQEVDVNEQRNLAFLKLYHNFLVPYNKEINQLKPELTKTTPSTDLPSGRQSGSTEWTKSRGENGES
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 45840 Sequence Length: 395 Subcellular Location: Cytoplasm EC: 3.5.1.52
Q6BNI6
MSSQGNKYEYGELADKLILAYSKRRLFKAIGTKRDRQQQFSRLDNKDKRFISKLIDVSNSNEKHKIPSELDIALDCIDLAKIYEGVDKREYERESKAKDPNLIYEDFIVLELLHYFKHDFFKWVNKPECSRCKQSSNNIVPTGNSGPPSINPSEISIIENYKCTKCNIAVSFPRYNNPIKLLETKSGRCGEWVNCFIFILRALLGSQSQIRYVWNHEDHVWCEYYSLGLKRWIHLDPCEGVFDEPNLYCENWGKKMSWCFAFGETYIMDVSDKYITKSDKQINKLESVSSLKNIKEFIDTLNDDKLVRYYSNMALTASDENRNLMRLYQEVILIHNSEKFNKENKIEVSRTHNIPTGRQTGDAEWTKSRGEDGNE
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 43898 Sequence Length: 375 Subcellular Location: Cytoplasm EC: 3.5.1.52
Q7F0R1
MVARRFVVRQGGGGGGGGEAEEHEVEYDTEHGLDILRLQIFSLTSVPPELQKIVVEADGSVVDDGTDLEAISEGLRLVAITGEEEEAEAAAAAEAARAQEKSDEELARMIQAEEEALLLQQYSIRNDGGEEFRERVEPYMHQVLMYEDPMRQEAARKTVPMDELQEKALVSLAKEGNFSPSKDEEDHAFLLQLLFWFKQSFRWVNAPPCDSCGRETFNVGMGTALPSEIKFGANRVEIYRCNYCSSTTRFPRYNDPYKLLETRKGRCGEWANCFTFYCRSFGYEARLILDFTDHVWTECFSNLYGRWMHLDPCEGVYDNPLLYEKGWNKKLDYVIAISKDGVRDVTKRYTRKWHEVLSRRIITSEDTVSAILSSITGKYRSGLSIDGLTALENRDKKESEELSKAAYLEVDTSISLPGRQSGSVEWRKASQKCSTYILSITSGNGCG
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 50513 Sequence Length: 447 Subcellular Location: Cytoplasm EC: 3.5.1.52
O74739
MDFHAISQRFIDMMRSKNSQNASQPPETYPFYHEVRQMSQHPWMYEDPELQDYALSILPLDKLFQDASELEKEGDGSWGYQDYVIQALLKWFKREFFVWVNQPPCEKCGGETHMTGNGPPNEEEKWNGVRNVELYQCNVCGHNQRFPRYNRIRALLDSRKGRCGEWANCFTFLCRALGSRARWIWNAEDHVWTEVYSNKQQRWVHVDSGEESFDEPLIYEQGWGKKMSYCLGFGIDSVRDVSHRYIRHPENGLPRDRCPESVLQQALHEINIEFRSRLTDSERKALEEEDKREKDELDGYMRPVSQATPTNTDLPARQTGNVEWKEKRGEAGK
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 39241 Sequence Length: 333 Subcellular Location: Cytoplasm EC: 3.5.1.52
Q6CAX5
MSQATFAKELTAKFAQLWTEKTKRPLPPVNQAMMQRLRQGQRQSGPNEVFSRVSALFRDLSLIPQSFENAELQDMAMEILPLDRLYSVAEERAEEEGERDNWGLQDYLIMELLRWFKQDYFTWVNSPPCETCGENGNVQFVRRENSTPEEQKYDASGTEVHQCSNCNTEIRFPRYNDLSKLMETRRGRCGEWAKCFAFFCRALGLRTRYIWNAEDHVWSEVYSERRKEWIHTDSCEEAWNSPTIYSQGWGKKMSYVVGFSGDGVTDVTRRYVRKADQQLPRTMVPDEQFKTILNSITSDIRQNLSPSEKEELKREDEAEERELASYNADEPQEAQMPRQSGSVEWTKARGEGGSDD
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 41494 Sequence Length: 356 Subcellular Location: Cytoplasm EC: 3.5.1.52
Q02890
MGEVYEKNNIDFDSIAKMLLIKYKDFILSKFKKAAPVENIRFQNLVHTNQFAQGVLGQSQHLCTVYDNPSWHSIVLETLDLDLIYKNVDKEFAKDGHAEGENIYTDYLVKELLRYFKQDFFKWCNKPDCNHCGQNTSENMTPLGSQGPNGEESKFNCGTVEIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTLILKSFGLDVRYVWNREDHVWCEYFSNFLNRWVHVDSCEQSFDQPYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQNELPRDQIKEEDLKFLCQFITKRLRYSLNDDEIYQLACRDEQEQIELIRGKTQETKSESVSAASKSSNRGRESGSADWKAQRGEDGK
Cofactor: Binds 1 zinc ion per subunit. Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Involved in the formation of free oligosaccharide in cytosol. Catalytic Activity: Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Sequence Mass (Da): 42485 Sequence Length: 363 Subcellular Location: Cytoplasm EC: 3.5.1.52
Q0CBN5
MNKKLKLFSMPGAQTSQIVIMLFQSLLHLLEAIASREPTRYIITYSIGNTHTPEIFSYSDLLQSARKAAGALRFKYHVVPGSVVLLHFNDHWNSMLWFWATLIADCIPAMSTPFSNNPETRLRHLKHLSTTLRSPKCLTTASLAAEFAGQEYITPICVQSLDYENLVHLPIKEGGDIAVLMFTSGSSGHCKVVPLTHEQILASLSGKAWTFPLPDNTAQLNWVGMNHVASLVEVHLFSIYTHSDQVHIPTVEVLSHVTLFLDLIHRHRVSRTFAPNFFLAKLRAALSADDTLAKYTGSLSNLRYIVSGGEANVTQTINDLAQMLKKCGAVSNVIVPAFGMTETCAGAIYNTSFPQYDVEHGLPFASVGSCMPGIQVRIVQLNGNGNSVPPGTVGNLEICGPVVLKGYFNDPAATKSTFTNDNWFKTGDLAFVDDNGMLVLAGREKDSIIVNGANYSPHDIESAIDEANIPGLISGFTCCFSTFPPSADTEEVIIVYLPNYTPADTVRRSETAAAIRKVAMMSVGVRATVLPLDRTMLEKSTLGKLARGKIKAAYERGDYKSYQEANEQMMALHHKVSHHQPRSGLEQSLLGVFTRTIPENLTEDFDVLTSIFDLGITSIELLKLKRGIEDLIGHGQIPLITLMTNPTIRTLSDALKQHAQQRDCSIYNPVVVLQSQGKKPPIWLVHPVGGEVMIFMNLAKFIIDRPVYGLRARGFNDGEDPFHTFEEIVSTYHASIKEKQPSGPYAIAGYSYGAKVAFDIAKALEHNGDEVRFLGLLDLPPSLNGTQMRAVAWKEMLLHICRMVGVIREEGIKKIYPRLEPENISPRHAIETVMGEADVTRLAELGLTASALERWANLTHALQRCIVDHKTNGSVAGADAFYCDPMASMAISNEQWACDYIGKWSDHTRSPPRFHHIAGTHYTILDAENIFSFQKTFLRALNDRGI
Function: Nonribosomal peptide synthetase that mediates the biosynthesis of phenguignardic acid . PngA alone is sufficient for phenguignardic acid synthesis . PngA first activates phenylpyruvic acid (PPA) through its A domain to AMP-PPA . The PPA unit is then loaded to the T domain and eventually transferred to the TE domain . Another PPA unit is then loaded onto the T domain . The TE domain likely promotes the enolate formation on the attached unit, followed by a nucleophilic attack on the carbonyl to yield an ether linkage between the two units . Finally, the TE domain probably catalyzes a similar reaction to give the cyclized dioxolanone core and releases phenguignardic acid . Catalytic Activity: 2 3-phenylpyruvate + H(+) = H2O + phenguignardate Sequence Mass (Da): 104487 Sequence Length: 946 Domain: AtrA has a A-T-TE domain architecture (Probable). The adenylation (A) domain recognizes and activates the aryl acid substrates, and loads them onto the thiolation (T) domain (Probable). The thioesterase (TE) domain shares the missing condensation (C) domain function, and is responsible for condensation and final product release (Probable). EC: 6.3.2.-
Q0A7A1
MKSVKKSFQYGNHTVTLETGGVARQADGAVLVNMSDTVVLVTAVGRKEADPGKGFFPLTVNYQERTYAAGKIPGGFFKREGRPSEKETLTCRLIDRPIRPLFPEGFYNEVQVVATVLSMNPEVDADIPALIGASAALSISGIPFDGPIGAARVGYKDGEYLLNPTFEETAASDLDLVVAGTENAVLMVESEANQLPEEAMLGAVLYGHEQMQVAIQAINELTAEAGKPRWDWHPPQGDAALETAIKDLVGDDLAAAYQIPEKQERQNRIGELRQRAVEALGENREEEGGWPEKDVGDAFKGLEKDIVRGRILAGERRIDGRDTRTVRPIDIEVGSLPRTHGSAIFTRGETQAVVVTTLGTGRDAQIIDAIEGERKEQFMLHYNFPPYCVGETGFMGTPKRREIGHGKLAKRGIEAVMPAADDCPYVIRVVSEITESNGSSSMATVCGTSLSLMDAGVPVKAPVAGIAMGLIKEDEQFAVLSDILGDEDHLGDMDFKVAGTESGVTALQMDIKIQGITREIMEQALEQAREGRLHILGEMNNAISGPRSEMSEYAPRLLTIRIDPDKIRDVIGKGGATIRALTEETGTTIDISDDGKVTIASADKAAADEARRRIELLTADVEVGTVYEGKVSKLMDFGAFVNILPGRDGLVHISQISNERVERVGDYLKEGDTVRVKVLEVDRQGRIRLSMKAVQDGE
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 75642 Sequence Length: 698 Subcellular Location: Cytoplasm EC: 2.7.7.8
B3EU51
MLNKIISKTISLPEHREITIETGKLAKQADGSVVVRMGDTMLLATVVFKQELDPTVDFLPLHVEYQEKFAAAGKIPGGFLRREGKLGDHEVLISRLVDRAIRPLFPDNYKHETQINIFLISADPEILPESLAGLAASAALMISPIPFEGPISEVRVARIDGQFVVNPTQSALEKADIDLMVGGSEKNILMVEGEMDEVQEADIIAAIQFAHEAIKLQCQVQKELADAVATLKFEAEPLQETENFELKDRTFKALYDKVYATAKKGITNKHLRKSSFKQIKKEYLKELLQQDPETSTVHFDKYYYELEKQVVRDLALNEGLRLDGRKLDEIRAIESEIDYLPAAHGSSLFTRGETQSLTTVTLGTKLDEQLIDRALLNGYSRFMLHYNFPSFSTGEVKFNRGPGRREIGHGHLAMRALKKVLPLDTENPYTIRIVSDILESNGSSSMATVCAGSLALMDAGISIRSAVSGIAMGLLMDEQTGKHAILSDILGDEDALGDMDFKVAGTAKGITACQMDIKVSGLTPQLLQKALEQAKAGRLHILGEMNKTITEPKTTYKKHAPSFSTMTIPKNMIGAVIGPSGKIVQEMQRETGTTIIIEEVEGKGIIKFFGPNQEAVQSAEKRVKDIVAEPVVGDVYQGTVKSIVPFGAFVEFMPGKEGLLHISEVKWERIENLDQVLELGEVIPVKLLEIDPKSGKYKLSRKVLLPNPKATEA
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 78662 Sequence Length: 713 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q2IQ01
MTPIQKTATVGGKEVLLETGKVAKQAHGSVWVRLGDSIVLVTAVSAAEKKEGIDFFPLTVDYQEKLFAAGRVPGSFFRREGRPTEKETLTSRLVDRSCRPLFAEGYSNETQVIATVISFDQENDTDVLALTGASAALHISDIPFGGPIAGVRVARVGGQLVANPTLAQRADADLDVVMAASRDAIVMVEGGAQEVSEAVMIEALLFGQAAVQPLLDAQDALRAATGNKPRRAFDPPKNDVELRAKVKALTWEKVKEAYGRDEKHDRYGRLSEIKKELLQALKEEAAGDAAKLATIALREKEIKGYYEDVKYDYMRKMITDERRRIGGRGMADIRKITCEVGLLPRVHGSSLFTRGETQALVATTLGTAEDEQRVEMLTGMVFKKFMLHYNFPPFSVGEVKFLRSPGRREIGHGALAERALRAVMPPEDQFPYTVRVVSDIMESNGSSSMASVCGGCLSLMDAGVPIKAPVAGIAMGLIKEGEKIAILSDILGDEDHLGDMDFKVCGTAAGITSIQMDIKIGGVTREILEQALSQAAEGRKHILGEMAKALSAPRGSISAYAPRITTIKIRPERIKDIIGPGGKTIKDITARTGTSINIEDDGSVSIASPNQDKVEEAIKMIRGLTQEAEVGRIYMGTVRKIAEFGAFVEIFPGTDGLIHISELSDKRVKSVSDVLSEGEEVMVKVISVDRSGKIRLSRKEALADSAKKSEGTEPPKGEPAK
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 77920 Sequence Length: 721 Subcellular Location: Cytoplasm EC: 2.7.7.8
O66593
MSVEEKARIGNSEEPIIIETGKYAKLTDGSVVVRQGGTAVLVTAVMSDEPITDVDFTPLAVDYRERASAYGRIPGGFTKREGKPTDREILVSRVIDRPIRPLFPEGFFHDVIITALTLSADDKYDPDVLAITGASAALHISRIPFEGPIAGVRVCRVNGEFVANPTYEQRKEADLDIVMAGTKDAIVMVEGGGKEIPEEVLADALFFGLDAIKEVIEAQERLREKVGKPKFEYQKVELPEDILKALEEECTPKILEAFNIKDKKERYSTLDKIVEEFIEAHQIPEELHFAVKYFYKKLESRLMREKVLKEGVRIDGRKPNEIRPIWIEVHPFERPHGNAIFTRGQTQAYVTVTLGTPDEALIIETIAEGEVFKRFMLHYSMPPFSVGEAKPWGPPRRREIGHGALAERAIEPLLPPEEEYPFIIRVVSDILESNGSTSMATVCGASLALFDAGVPMKDNKHVAGIAMGLILEKDRYVILSDILGDEDHLGDMDFKVAGTKDGITSVQMDIKVKGITKEIMLDALKQAREGRLYILEKMYEAIPEPRKEPHPYTPKVEVVDVPEEKAPLIIGPGGSTVKKIYDETGVKVWVGEQGKVYLFVFPGGDVEKAKQMIQDIVREVEVGAVYKGTITRVEPYGVFVELWPGKIGLLHVSKMAEPVRSATEKYKVGEEIIVKVLDLDELGRPRFTTIGIEDVGTEKKEVKPKVGDVYEGKVVRVEPYGAFIEYAPGKVGLLHVSKMKERVKDARQKYKVGDVVKVKVVEIDEQGRPKFTDDV
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 86489 Sequence Length: 775 Subcellular Location: Cytoplasm EC: 2.7.7.8
A1BDY1
MIINKAIDLGKGKILSIETGKMAKQADGAALVRLGDTMVLATVVSSKTPPPANQDYFPLQVEYREKYSAAGKFPGGFFKREGRPSEKEILTARLIDRALRPLFPDGYLFETQIIVTVFSSDQINDADVLGGVAASAAIMVSDIPFHNSMSEVRVGRINGEFIVNPNINELQGSDIDICIGGTANTICMLEGEMKEISEAEMLDAIKFGHEAIRKICALQDEMAAEIARPQRSFAPVKAPAKLKEVIAGLSETRLKELAYTPLCKEDRAEKTASVYKETLQSTLELFKALLTPEEIAAEPEKALCLNAHIIEEEIHAVEKKVMRHMILDDGKRLDGRTLDEIRPISIELGIIPRAHGSALFTRGETQALVTITLGTKKDAQSVDTLTDSADKRFMLHYNFPPFSVGETGRVGGTGRREIGHGNLAERSIKMVSPSETDFPYTIRIVSDILESNGSSSMASVCGGTLALMDGGVPIRKPVSGIAMGLIKEGDAYSVLSDILGNEDHLGDMDFKVAGTEDGITACQMDIKIDGLDYHILETALEQARKGRLHILDKMEVAIPISRGELAQYAPRLTSIQIPVDAIGLIIGKGGETIRSITEETGAEINIEDDGTVTIACSSPEGTNAAVETIKTLISKPEIGNTYLGKVRDIRDELGAFVEFLPKTDGLVHISEISKERVTKVSDHLKVGDRVKVKLVDIRKDPRTGKNRFALSIKAVESEPEKSDENKAGTEGN
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 79495 Sequence Length: 732 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q9Z6R0
MNFQTISINLTEGKILVFETGKIARQANGAVLVRSGETCVFASACAVDLDDKVDFLPLRVDYQEKFSSTGKTLGGFIKREGRPSEKEILVSRLIDRSLRPSFPYRLMQDVQVLSYVWSYDGQVLPDPLAICAASAALAISDIPQSNIVAGVRIGCIDNQWVINPTKTELASSTLDLVLAGTENAILMIEGHCDFFTEEQVLDAIEFGHKHIVTICKRLQLWQEEVGKSKNLSAVYPLPAEVLTAVKECAQDKFTELFNIKDKKVHAATAHEIEENILEKLQREDDDLFSSFNIKAACKTLKSDTMRALIRDREIRADGRSLTTVRPITIETSYLPRTHGSCLFTRGETQTLAVCTLGSEAMAQRYEDLNGEGLSKFYLQYFFPPFSVGEVGRIGSPGRREIGHGKLAEKALSHALPDSATFPYTIRIESNITESNGSSSMASVCGGCLALMDAGVPISSPIAGIAMGLILDDQGAIILSDISGLEDHLGDMDFKIAGSGKGITAFQMDIKVEGITPAIMKKALSQAKQGCNDILNIMNEALSAPKADLSQYAPRIETMQIKPTKIASVIGPGGKQIRQIIEETGVQIDVNDLGVVSISASSASAINKAKEIIEGLVGEVEVGKTYRGRVTSVVAFGAFVEVLPGKEGLCHISECSRQRIENISDVVKEGDIIDVKLLSINEKGQLKLSHKATLE
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 75347 Sequence Length: 694 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q8KBY3
MFIKKKIDLGHGKVITIETGKMAKQADGSAVVTMNDTMVLATVVSSKTPPSPNQDFFPLQVEYREKYSAAGKFPGGFFKREGRPSEKEILSARLIDRALRPLFPDGYYQETQIIISVISSDTINDADVLGGIAASAAIMVSDIPFANPMSEVRVGRINGLFIVNPDINELAQSDMDICIGGTEDTICMLEGEMKEISEAEMLDAIKFGHDAIKKICALQRELAAEVAKPKRPFSPTVAPDELVNFVEEHCSAELKALAYTPLAKEERAEKTKAIYTQTIRKTLTHFTDRVGPDQIEADPTSAFCLNEHMIEECIHAVEKKVMRHMILDDGKRLDGRTLEQVRPISIELGLIPRAHGSALFTRGETQALVTLTLGTKKDAQSVDTLTDDKDKRFMLHYNFPPFSVGEIGRVGGAGRREIGHGNLAERAIKMVMPSEQEFPYTVRLVSDILESNGSSSMASVCGGTLAAMDGGIPLKKPVSGIAMGLIKEGDRYAVLSDILGNEDHLGDMDFKVAGTRDGITACQMDIKIDGLDYHILETALEQARKGRLHILDVMAEAIPESRADIGKYAPRLTTIQIPVDAIGMVIGKGGETIRSITEETGAEINIDDDGTVTIACSSPEATKAAVETIKTLVSKPEVGTIYMGKVRDIRDELGAFVEFLPKTDGLVHISEIARERIAKVSDVLKVGDRIKVKLIDVRKDPRTGKTKFALSIKALLDTDQQAETNGEAKPARD
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 79938 Sequence Length: 733 Subcellular Location: Cytoplasm EC: 2.7.7.8
O84849
MAFETFSVALDKDKTLIFETGKIARQASGAVLVKMNETWVFSSACAASLSEAVDFLPFRVDYQEKFSSAGRTSGGFLKREGRPSEREILVSRLMDRSLRPSFPNRLMQDIQVLSYVWSYDGKTLPDPLAICGASAALAISEVPQNCIVAGVRVGLVGGKWVINPTRDELSASKLDLVMAGTASAVLMIEGHCDFLTEEQVLEAIAFGQTYIAKICDAIEAWQKAIGKQKNFSAVLDMPEDVQNVVSDFIREKFEKALSFRDKEALEQASKELEESVIANLVQEENSDFSLLNVKAAFKTAKSNQMRALIQDLGIRVDGRTTTEIRPISIETPFLPRTHGSCLFTRGETQSMAVCTLGGENMAQRFEDLNGDGAARFYLQYFFPPFSVGEVGRIGSPGRREIGHGKLAEKALSHVLPETSRFPYIIRLESNITESNGSSSMASVCGGCLALMDAGVPIKAPVAGIAMGLILDRDQAIILSDISGIEDHLGDMDFKVAGTAKGITAFQMDIKIEGITHKIMEQALAQAKQGRSHILNLMTQVLASPKGTVSKYAPRIETMQINTSKIATVIGPGGKQIRQIIERSGAQVDINDDGVINIAASTQESINKAKELIEGLTGEVEVGKVYNGRVTSIATFGVFVEVLPGKEGLCHISELSKQKVDNISDFVKEGDKLAVKLLSINEKGQLKLSHKATLED
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 75499 Sequence Length: 695 Subcellular Location: Cytoplasm EC: 2.7.7.8
A5CSN9
MEGPEIKFAEAVLDNGKYGTRTVRFEAGRLAQQAQGAVAAYLDEDTMLLSATSVGKHPKDNFDFFPLTIDVEERSYAAGKIPGSFFRREGRPSTEAILVCRLIDRPLRPSFITGLRNEVQVVITVLSIAPDEFYDSLAINAASASSMLSGIPFSGPIAGVRLALIGDQWVVFPKHSQLKEAVFDITVAGRVVTDSEGNEDVAIMMVEAEATEGAWDLIQGGATKPDEAIVAQGLEAAKPFIQQLVAAQASLAQQAAKPTVDYPVFLPYAQETYDAVSALALDELGTVYQTADKIERQDADDALKTRTKEAVAAKVEAGELPQSALTEFSAAYKSVTKTVVRGRILRDGVRMDGRGLADIRPLDAEVQVIPRVHGSAIFQRGETQILGVTTLNMLKMEQQIDSLSPITKKRYLHHYNFPPYSTGETGRVGSPKRREIGHGFLAERALVPVLPSREDFPYAIRQVSEALGSNGSTSMGSVCASTLSLLNAGVPLRAPVAGIAMGLVSDTVDGQVRYAALTDILGAEDALGDMDFKVAGTSEFVTAIQLDTKLDGIPTSVLDGALKQAKEARTAILGVLNQAIDGPDEMAPTAPRVISVNIPVDKIGELIGPKGKTINAIQDETGADISIEEDGTVYIGAVDGPSADAARAQVNAIANPTNPEVGESFLGTVVKIATFGAFVSLLPGKDGLLHISEVRKLAGGKRVENVEDVLGVGQKILVEITKIDDRGKLSLAPVLEETADQEGRDAASHGSEAPAEG
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 80380 Sequence Length: 757 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q73VX0
MSVAEIEEGVFEATATIDNGSFGTRTIRFETGRLAQQAAGAVVAYLDDENMLLSATTASKSPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTILSLDPNDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVAFPTVEQLERAVFDMVVAGRKVDGADGPDVAIMMVEAEATSNVIELIDGGAQAPTETVVAQGLEAAKPFIEVLCTAQQELADKAARPTSDYPTFPDYGDDVYYSVASVATDELSKALTIGGKAERDARTDELKAEVLARLAETYEGREKEVSAAFRSLTKKLVRQRILTDHFRIDGRGITDIRALSAEVAVVPRAHGSALFQRGETQILGVTTLDMVKMAQQIDSLGPETTKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSLEDFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDIEVEAGDGTKSLERRFVTLTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLDGIPSQVLAGALSQAKDARLTILEVMAEAIDEPDEMSPYAPRVTTIRVPVDKIGEVIGPKGKIINAITEETGAQISIEDDGTVFVGATDGPSAQAAIDRINAIANPQLPTVGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIDKRGKISLVLVEEDNSAPADTPAAAPADATS
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 80542 Sequence Length: 757 Subcellular Location: Cytoplasm EC: 2.7.7.8
A0QVQ5
MSVVELEDGVYESTAVIDNGSFGTRTIRFETGRLAQQAAGSAVAYLDDETMLLSATTASKNPKDHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTVMSLDPKDLYDVLAINAASMSTQLAGLPFSGPVGGARIALIDGTWVAFPTVEQLERAVFDMVVAGRIVGDGDSADVAIMMVEAEATENVVELVAGGAQAPTEAVVAEGLEAAKPFIKALCAAQQELADRAAKPAGEYPVFPDYEADVYDAVASVATEALAEALTIAGKTERNDRTDEIKVEVLERLAEPYAGREKEIGAAFRSLTKKLVRQRILTDHFRIDGRGITDIRALSAEVAVIPRAHGSALFERGETQILGVTTLDMIKMAQQIDSLGPENTKRYMHHYNFPPYSTGETGRVGSPKRREIGHGALAERALVPVLPSIEEFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDVDVDGKVEKRYVALTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLDGIPSQVLAGALSQAKDARLTILDVMAEAIDRPDEMSPYAPRITTIKVPVDKIGEVIGPKGKMINSITEETGAQISIEDDGTVFVGAADGLSAQAAIDKINAIANPQLPKVGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVKVGDKLRVEIADIDNRGKISLVLVAEESAESAESAGDKGAEKAEGAAADVTPAEA
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 81027 Sequence Length: 763 Subcellular Location: Cytoplasm EC: 2.7.7.8
A3PY93
MSVVEIEDGVYESTAVIDNGSFGTRTIRFETGRLAQQAAGAVVAYLDDETMLLSATSASKSPKDHFDFFPLTIDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPTFVSGLRNEIQVVVTVMSLDPKDLYDVVAINAASASTQIAGLPFSGPVGGVRVALIDGTWVAFPTVEQLERAVFDMVVAGRKTADDVAIMMVEAEATDKVVELVAGGAQAPTEAVVAEGLEAAKPFIKVLCEAQQELAGRAAKPTADYPLFPEYGEDVYYAVASVATDALSEALTIAGKEERNNRTDEIKVEVLGRLADQFAGREKEIGGAFRSLTKKLVRQRILTDHFRIDGRGVTDIRALSAEVAIVPRAHGSALFERGETQILGVTTLDMVKMAQQIDSLGPETSKRYMHHYNFPPYSTGETGRVGSPKRREIGHGALAERALMPVLPSVEEFPYAIRQVSEALSSNGSTSMGSVCASTLSLLNAGVPLKAPVAGIAMGLVSDDVEVDGKTERRFVTLTDILGAEDAFGDMDFKCAGTKDFVTALQLDTKLDGIPSQVLAGALAQAKDARITILEVMAEAIDAPDEMSPYAPRITTIKVPVDKIGEVIGPKGKMINSITEETGASISIEDDGTVFVGASNGEAAQAAIDKINAIANPQLPKIGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGRGKRIAKVEDVAKVGDKLRVEIADIDNRGKISLVLVAEEEAAEASDNGSATPSDKAPATADATTAGN
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 80676 Sequence Length: 759 Subcellular Location: Cytoplasm EC: 2.7.7.8
B2A3A3
MPTTVSEEIAGYQLTLETGELAKQANGAVKVQYGNTVVLVTATASKEPKDDLNFFPLTVDYEERLYAVGKIPGGFIKREGKPTEKATLTARLTDRPIRPLFPDGFRNPVHIVSTVLSVDQNCPPEIASIIGASAALSISDIPFDGPIASVKVGKVNDEIVVTPDVDEHEESQLDLVVAGTKDAIMMVEAEANELPEDEMLEAIMKAHEEIKKIITMQEQLVEQVGQKKMEVELDLPSDELVSEVEELALEDIEKVLQIKDKLEREDAMDEAKQKVVDHLLEKYNSEENEDEEEELKEKHIKSAFDSILKREMRSRIIHENSRPDGRGQKEIRPVTCDVDLLPNTHGSGLFTRGQTQVLNVCTLGALGDVQILDGLDIEESKRYMHHYNFPPYSVGEAGFMKGPGRREIGHGALAERALKPMIPTEKDFPYTIRLVSEVLESNGSTSMGSVCASSLSLMDAGVPIEKAVSGIAMGLIKEGDQLAILSDIQGIEDFLGDMDFKVAGTEDGITALQMDIKISGTTREILKQALKQGKDGYLHILNIMKQTISEPREELSPLAPRVIKKQIDPDKIRNVIGPGGKMINKIIDETGVKIDIEPDGLIYISSSDAEQAEQAIKAIDELIKEPEVGEVYLGKVVRTEKYGAFVEILPGKEGLVHISELAEDRVGKTEDVAKVGDEILVKIINIDERGRINLSRKQALGEEDGKTNNDDKKSTKKT
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 79043 Sequence Length: 718 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q9ZD43
MFNEITKSVMWNGQVLEISTGKIARQANAAVTVKMGNSILLCTCVVANKVKDGIGFFPLTINYREMAYSAGKIPGGFFKREGKASDREILVSRLIDRPIRPLFHQAFMHETHVTCSVLSYDPATPVDILAIIGASAALSISPAPYLEIVAASKVGLINGEFVLNPTLELLKTSQLDLVVAGTEDSVMMVESEAHLLSEDKMLEAVKFGFESFQTVIKLIKELAKEAKKPKFEMQDLYPSSLKKEIEKLFTKEVEQAFEIKSKQERSTDLALIYEKVLTHFVRDIENKKYNNYQIESALKAISADILRNKILEKNIRIDGRSTTDIRQIACEVGLLPSAHGSALFTRGETQSLVSTTFGTSLDEQIVDSLEGEYKERFMLNYIFPPYSVNEAMPMKAPSRREVGHGKLAWRAINPILPNKVQFPYSIRVVAETTESNGSSSMATVCGSSLALMHAGVPIKAPVAGIAMGLVKESNKFAVLSDIIGDEDYFGDMDFKVAGTSSGITALQMDIKISGIDFKIIQIALEQARLGRLHILEQMNKVISKPNSELSKNAPSSTTVKIDKDKIKDIIGPGGKIIKEICETSNAKIDISDDGTVSIYASDRDKIKIALDKIKAIAVEPEIGEIFNGTVMKVLDSGAFINYLGNKDGFVHISEISDARIDKVSSVLKQGDIVKVKLIGFDNKGKAKLTIKNAYKDHSSNNTKQKNNVKDDSESEQRRDTSKKRTWNEDNNTEMSEVITERKYFT
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 82340 Sequence Length: 745 Subcellular Location: Cytoplasm EC: 2.7.7.8
B8I2R5
MFKSFSMELAGRTLTVETGKLAQLANGSALIRYGDTVIMSSATASAAPRDGIDFFPLSVDYEERLYAVGKIPGGFIKREGKPSEKAILTSRVIDRPIRPLFPKDLRNDVAVVNTVMSVEQDNSPEIAAMIGASVAISISDIPFNGPIGGVVLGLVDGEVIINPNEEQRAKSKMYVTLAGTKEKITMIEAGADIVPDDVMFDAIKKGHEEIKKICDFINGIVKEVGKAKFTYESADVPADLFEVVKEFAYDKMRIAVLATDKQDRDAKVSQLTEETQAALAEQFPEMESKINDALYKLEKKVVREYILKEGKRIDGRRLDEIRTLSAEVGILPRTHGSGLFERGQTQVLTTVTLGAMGDVQMLDGIDTEETKRYMHHYNFPGYSVGEAKTSRGPGRREIGHGALAERSLVPVIPTETEFPYAFRLVSEVLMSNGSTSQGSVCGSTLALMDAGVPIKAPVAGISAGLVIDEENPDNFVTFMDIQGIEDFFGDMDFKVAGTTEGITAIQMDIKVDGLSYEIIRQAFELTRMGRLQIINDVILKAIPQPRKELSEYAPKIITTNIDPEKIRDVIGPGGKMINKIIAETGVKIDIEEDGRVYILTPDSAAAQKALKIIQGIAKDIEPGEVYLGKVVRITTFGAFVEILPGKDGLVHISKLDKKRVEKVEDVVSIGDEILVKVTEIDKQGRINLSRKDAMAEENTTEEK
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 76926 Sequence Length: 703 Subcellular Location: Cytoplasm EC: 2.7.7.8
A1AWB1
MGINTKSFVMGKHTITLETGRIARQAHGAVLVSMDDTQVLVTVVGSKKMHPGQDFFPLSVDYIEKTYAAGKIPGGFLKREARPSEKETLTSRLIDRPIRPLFPNGFMNEVQVLITVISANSEVDPDIISMLGVSAALSISGIPFNGPIGSARVGYSNGKYTLNPTYTELVDSDLDMVVAGTDKAILMVESEASELSEKIILDAIIYAHEQYQVAITNIAEFVTQVGVQKWDWEAPATNEVLLSNIKSQFGKQINEAYKIKEKLNRHVKVGEIKTAAIEALVNEDKNGNSIDEVSKYFNKVEKSTVRERILNNDPRIDGRDNETVRELKIETGVLENTHGSALFTRGETQALVVTTLGSKREAQLIEKLESSERQNDYFLLHYNFPPYCVGEIGRVGTTKRREIGHGRLVRRGIAACLPSIEEFPYTVRVVSEITESNGSSSMASICGASLSLMDAGVPIKAPVAGIAMGLVKEGDRFTILTDILGDEDHLGDMDFKVAGTSRGINALQMDIKIQGITREIMEIALKQAKEARLNILGQMNQVICEPNTSNKNTPKTAVIKIQTDKIRDLIGKGGETIKGIISTSSASVDVDDNGNVNIFSNDQKSFDTAMQMVKDVTTTPKIGKVYTGKVVKIVDFGAFINIKPNQDGLLHISEIAHERVDKVENHLKEGDEIDVKVLSLDRGRIKLSRKVLLEK
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Catalytic Activity: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n) Sequence Mass (Da): 76315 Sequence Length: 695 Subcellular Location: Cytoplasm EC: 2.7.7.8
Q9NPJ4
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV
Function: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery . May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs . Required for UPF1/RENT1 localization to the P-body . Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Also acts as a nuclear receptor coactivator . May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). Sequence Mass (Da): 15591 Sequence Length: 139 Domain: The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif. Subcellular Location: Nucleus
Q75EG5
MYGKSGPPPEGYVPQHPPAQGYAPHNPPPGYVHENPFQEPVPQGQEYSPQGQQYQFRKDQYYNLDHQGSGAPIGDASFEDKFPTEAGNRLKFNDWPFTIIFLLTVGAFIAVAVLTLRGWSLSPTSNGSGIYDGDNTHTLNTNAAILLLISCGVAVALSVFGLVLAGMYTKFFIYAAMILNTVVGLGTAITYLVLRHWSAGIVFMIFTILTAVCYWLMRSRIPFSVAVLRTVMSVMKKHPQTWLVSLLGTIVSAAFSVIFSVVLVATYIKYDPKSENGGCDVSGGSCSRGKLIGILVLVFFCGFYISEVIRNVIHCTIAGIYGCWYYFSKSDQGMPRWPAFGSLKRALTTSFGSICFGSLIVSLIQLLRQIIQLLRNGIISGISDSGWMQCLWLILDAVVGVFEWMAEYFNHYAYCFIALYGKPYLRAAKETWHMLREKGIDALINDNLINLALGFYTLFVGYTTALFSYLFLRFTKPDYNSGGGFNAVLMAFSFLIAIQLTHVATETIRSGTATFFVALGNDPEIFRVSYPQRFDEIFRAYPDVLNKLSHQHV
Function: Probably involved in transport through the plasma membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61473 Sequence Length: 553 Subcellular Location: Cell membrane