ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
F4K2M8
MPTGCEFPMIKTFENALTAADFESTVELTNFPAVFRGCASVWDAYSKWNPFNSGLDYLEERAGSVEVEAMLSRTAPVFNGDIRSHERVSLPFSDFIRFCKQHMRGKGNGSGVDAKSADLNPMCEDYRPGQIYLAQFPILNDEKEEKVLLKILRQDIQTPTFLDAKSLSSINFWMNSAEARSSTHYDPHHNLLCVVSGRKKVVLWPPSASPSLYPMPIYGEASNHSSVGLENPNLSDYPRAEHSLKQSQEITLNAGDAVFIPEGWFHQVDSDELTVAVNFWWQSNYMSNMPEHMDSYYLRRITRSLLVSKPSSTDLRHLSE...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: May function as histone H3 lysine demethylase and be involved in regulation of gene expression. Sequence Mass (Da): 61906 Sequence Length: 549 Subcellular Location: Nucleus EC: 1.14.11.-
Q0WVR4
MAKEIENLWREVRELSLGTKIDRFDSQPSPVKFLRNYVSQSKPCVISKAITHWPALKLWSDPAYLTGALSDDVVSLHLTPNGCADAVTGDSDLCFASAHVEKVLFPEALKVVQSSCKGLKVGYLQQQNDCFRTEYSTVALDCDGDIEWATEAFGCSPEAVNLWIGTDDSVTSFHKDHYENLYAVVSGEKHFLLLPPTDVHRLYIEQYPAANYSYHRDTDAFKLEVEEPVRHVPWSSVDPYPSPEKEASERLKFPLFFDGPKPFHCTVKAGEVLYLPSMWFHHVSQTPGDGGYTIAVNYWYDMQFDIKYAYFNFLQSLLYK...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and H3K27me2, and involved in the regulation of gene expression . No activity on H3K27me1 . Together with JMJ30, regulates the flowering-repressor FLOWERING LO...
Q08BY5
MDRETFHSCSSLVKLPRQIHQQHCSSHFIEYIEREIPYSKFFKNYLIPNQPCMFSKKFTEEWNCRKKWVTAEGKPNLQRLLHEFDETPVPVANCSVKEYNANPKQIMPFKEFIQYWRESIQNGHSSPKGCLYLKDWHMQRNFPEHNIYKTPIYFSSDWLNEYWDTIEVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDFLRDCHGNLAYDVTAPILQDKGLYAQFEEACQPLEIIQEAGEIIFVPSGWHHQVYNLEDTISINHNWLNGCNLDIMWQFLQDELSSVQREIEEWRDTMDTWHQHCQ...
Function: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. Catalytic Activity: 2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate Sequence Mass (Da): 49892 Sequence Length: ...
Q9VJ97
MASEERDGDVLLQLHPEEVVETDPQLPEEIERCSGLDYNDFFWRYMHKNIPVIIANVSNDWECQNWTVGQSSPESRDLNSNPSASSINFDYLKTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNLYLKDWHLAAQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSFSWSTNIVGLKKWLIMPPGEELKLNDRLGNLPFSIDEKMLDEHNVRYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNWFNGCNISMVWQNLKNNLKAVC...
Catalytic Activity: 2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate Sequence Mass (Da): 49169 Sequence Length: 425 Subcellular Location: Cytoplasm EC: 1.14.11.-
Q9H9V9
MRAGPEPQALAGQKRGALRLLVPRLVLTVSAPAEVRRRVLRPVLSWMDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNL...
Function: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. Catalytic Activity: 2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate Sequence Mass (Da): 52493 Sequence Length: ...
Q8BFT6
MDRETRTFAERYYRDLRDPVPSGGGGPTPSGVTFIQTPNAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPDFEYLQQKYGDAVVPVANCGVREYNSNPKEHMSFRDYISYWKDYIQGSYSSSRGCLYLKDWHLCRDSLVNDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHADIFRSFSWSVNICGKKKWLFFPPGEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQEPGEMVFVPSGWHHQVYNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSM...
Function: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1 (By similarity). Not essential for embryonic stem cell (ESC) maintenance and the embryonic and postnatal development . Catalytic Activity: 2-oxoglutarat...
Q58DS6
MNHKSKKRIREAKRSARPELKDSLDWTRHNYFESFPLNPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTREEGGNQQDEAITWFNIIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEH...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylat...
B1P1G9
MKTSVLVTVLGLAVISVLCSASQDEEQDMYDELLSAVFEVNDELQSEARCGEKNDRCKTNQDCCSGFRCTKFRRCGRR
Function: Probable ion channel inhibitor. Sequence Mass (Da): 8788 Sequence Length: 78 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
B1P1H0
MYDEILSAFFEVNDELQSEARCGEKNDRCKTNQDCCSGFRCTKFRRCGRR
Function: Probable ion channel inhibitor. Sequence Mass (Da): 5918 Sequence Length: 50 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
B1P1E5
MKTSVLLVILGIAAITVQCTASESVEQDSLRTFVDTVLGWNAEMASEARCGGWMAKCADSDDCCETFHCTRFNVCGK
Function: Probable ion channel inhibitor. Sequence Mass (Da): 8327 Sequence Length: 77 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
B1P1F8
MQVSVLITLAVLGVMFVWTSAAELEERGSDQPAWLKSLERIFQSEERDCRALYGGCTKDEDCCKHLACRRTLPTYCAWDLTFP
Function: Probable ion channel inhibitor. Sequence Mass (Da): 9461 Sequence Length: 83 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
A0A330KW27
MNTKLVVVFLLSAILFVSVTASRPGKDLERDEAYETYDDENKRACKDVFPAATCRHAKSVGNCSSEKYKRNCAITCGAC
Function: Toxin that weakly blocks two voltage-gated potassium channels (IC(50)=1.8-2.5 uM on Kv1.2/KCNA2 and IC(50)=5.6-6.2 uM on Kv1.6/KCNA6). PTM: Two similar peptides (OspTx2a-p1 and -p2) are obtained after synthesis and oxidative folding. They may differ by a D-Cys at position 76 (corresponding to OspTx2a-p2). Sin...
P23354
MSLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALGVLGVGNAGVFEALFRERGITDHCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQGVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASAAGARVLLDTSGAPLVAALAAAPVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRDQQLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRITPEGVRDAAAAVVIGAVP
Function: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate. Catalytic Activity: ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+) Sequence Mass (Da): 32592 Sequence Length: 318 EC: 2.7.1.56
Q2HRD5
MFLYVVCSLAVCFRGLLSLSLQSSPNLCPGVISTPYTLTCPSNTSLPTSWYCNDTRLLRVTQGTLTVDTLICNFSCVGQSGHRYSLWITWYAQPVLQTFCGQPSNTVTCGQHVTLYCSTSGNNVTVWHLPNGQNETVSQTKYYNFTLMNQTEGCYACSNGLSSRLSNRLCFSARCANITPETHTVSVSSTTGFRTFATAPTLFVMKEVKSTYLYIQEHLLVFMTLVALIGTMCGILGTIIFAHCQKQRDSNKTVPQQLQDYYSLHDLCTEDYTQPVDWY
Function: Promotes host cell survival pathways and may contribute to pathogenesis by preventing infected cells from undergoing apoptosis. Acts in host B-cells by mimicking the activated B-cell receptor complex. The cytoplasmic tail of K1 can induce the phosphorylation of a number of different kinases, leading to the ac...
Q5A4Q1
MSIEDLKNTVTKLQERIQELEKKAGIIPDVPKSVRMVLIGPPGAGKGTQAPNLKEKFCACHLATGDMLRAQVAAKTALGVEAKKIMDQGGLVSDEIMVNMIKSELENNQECSKGFILDGFPRTIPQAEKLDSMLESRKTPLEKAVELKIDDELLVARITGRLVHPASGRSYHKLFNPPKKDMTDDVTGEPLVQRSDDNEDALKKRLVTYHKQTEPIVAYYQKTGIWSGVDASQKPTKVWSDILKCLGQN
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Catal...
Q6FM32
MSSSDSIRMVLIGPPGAGKGTQAPNLVERFHAAHLATGDMLRSQISKGTELGLQAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDNMLKERGTPLEKAVELKIDDELLVARITGRLIHPASGRSYHKLFNPPKEDMKDDVTGEPLVQRSDDNEDALKKRLGAYHDQTEPIVDFYKKTGIWADVDASQPPETVWSAILKALGKN
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Catal...
P0CO43
MSGNSEVEYLKSLVSQLQDKIHHLEKSTSTSVSNTISSVTSALSPSSSIKPPRMVLIGPPGAGKGTQAPNISSKYCICHLATGDMLREQVARQTELGKAAKQIMDQGGLVSDEIMVGMIKQELEKNAECKNGFILDGFPRTVPQASKLDAMLAERKQAIDHAIELKIPDVLLISRITGRLVHPASGRSYHKEFNPPKKPMTDDITGEPLIQRSDDNVGTLRKRLDTYHAQTGPVVDYYKGTGVWTPVDAAQSPKLVWASISSILESKKN
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Catal...
Q1L8L9
MAPSTQEDDTVSGIRKGIRAILLGPPGAGKGTQAPKLAEKYCVCHLATGDMLRAMVASGSELGQRLKETMDAGKLVSDEMVVELIDNNLDTPACKNGFLLDGFPRTVKQAEMLDDLMEKRSEKLDSVIEFSVDDSLLVRRICGRLIHQPSGRSYHEEFHPPKEHMKDDVTGEPLIRRSDDNETTLRSRLESYHRQTSPLVQYYSARGLHTAIDASQSTDLVFASILAAFSAATCKDLVYFV
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays...
Q54QJ9
MEPQFKVKIDNDSARILKELAEKKRDEGLRVVFIGPPGSGKGTQAPLVKEDYCLCHLSTGDMLRAAIEQGTETGKQAKTIMDQGGLVPDEVMVNMIKENIQTPECKKGFILDGFPRTVPQAEKLDKMLAEDNKKIDHVLDFAIDDSLLVKRITGRLVHPSSGRSYHREFFPPKVDMIDDITGEPLIQRSDDNEEVLKKRLESFHKNTTPVLGYYQNKGILSTIDASKSAPFVSHTIKSIFLSTLHFPHNASIFKTFHQKMKMQVHSTETPLAAEIL
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Catal...
Q8UE38
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVSDDIVNQIVSERIEAPDCAKGFILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEALIRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAPLSAYYSEQGELVTLDGMADVDAVTEAIERVLEKASA
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 21177 Sequence Length: 196 Domain: Consists of three domains, a large ce...
Q2IJ70
MILILLGPPGAGKGTQAKLLSTELGIPHISTGDMFRDHKARGTEIGKQVQAIMDGGGLVTDDITNAMVKERLSRPDVAPGFILDGYPRTVVQAEYLDGLLRSLGRSIGRALSYEVAEELVVERISGRRSCPRCGAVYHVSQNPPRRAGYCDRDDAELVQREDDKPENVRKRMQEYGTKTEPLKRYYRDRGELTEVEGVGTPEGILAATKKVLGR
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 23564 Sequence Length: 214 Domain: Consists of three domains, a large ce...
B2KEK1
MIIVLLGAPGAGKGTQSVLVAEKYGLKHISTGDLLREEIANNTELGKQAKKLIDGGNLVPDEMILGLLKNAFLNRGKGVVLDGFPRTLSQAEMMHPIVKGLAEKLSAVINIKLSEDEITQRIVLRRQCKNCGNIFNLRFIKNFDGKCPKCGSTDIYQRADDNEESAKNRINVYHSQTEPVVGFYKNKTYYKEVDGSKNKEEVFEEISKFINRKK
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 23933 Sequence Length: 214 Domain: Consists of three domains, a large ce...
Q8SVC2
MKYSRIVVMGPPGCGKGTQSSLISEKYEIPHVSSGDIIREEMKKSSKEATVIREMVNSGRLAPDEIVNELVLKKIRSMSKYILDGYPRRIEQAGMLGDDVDLVIFIDVDEDTCISRICGRNEGRDDDDEEVGRKRCMVYNKETAPVLEFYKRHGKLLTINGCASPGTVFEEIRRSIE
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 19963 Sequence Length: 177 Subcellular Location: Cytoplasm EC: 2.7.4.3
B1GZA3
MNYIILGPPGAGKGTQAKKIAVKFGILHLSTGDMFREAKKSDESISKLLSSGQLVPDEIVVNMVRKRLEKNNIKKGFLLDGFPRTVKQTGELDRMLMSENIKIDSVFLISVPFEEAAKRIAGRIVCACGASYHTMLLPPKEFGKCDCCGGVLFHRSDDKEEDIIRDRFSVYEKQTKPLIEYYKESGLLIYIDGLKSESDVFEQISGCIINGE
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 23659 Sequence Length: 212 Domain: Consists of three domains, a large ce...
O96907
MAKVFLIMLGGPGAGKGTQCANIEKHLNSSAHISTGDLLRAEIKNKTEIGLKVEDIIRNGQLVSDEIICNMVNNFIAKNEKEVIVFDGYPRAVSQLEALLKEATAETKICVINLEIPDEILIQRIVSRGKTSGRADDNTEAAAKRLAVYHAQHDEMIKAIKAKNLPYFVVDHLGGPDEVFNEIKGVFANVGLH
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP . Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 21102 Sequence Length: 193 Subcellular Location: Cytopl...
Q2S1E4
MRLIIFGPPGAGKGTQAGLLEERHGITQISTGDILREAMAQETELGQKAKSYIDAGELVPDALVRDLAEQAIADEGHDDFMLDGYPRTDQQAEWLTEFLASNETPLDGVLSMKVPDDVLVRRLSRRRVHEETGETYHLDHDPPPEDVDPDLIVQRSDDEPETIQNRLDVYREETAPLATYYEERDLLVPVDGTGGIEEVFGRIEEALDALER
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 23722 Sequence Length: 212 Domain: Consists of three domains, a large ce...
P25824
MTDQKLAKAKVIFVLGGPGSGKGTQCEKLVQKFHFNHLSSGDLLRAEVQSGSPKGKELKAMMERGELVPLEVVLALLKEAMINWLTKIVISLSIRYPRELDQGIKFEKEVCPCLCVINFDVSEEVMRKRLLKRAETSNRVDDNEETIVKRFRTFNELTKPVIEHYKQQNKVITIDASGTVDAIFDKVNHELQKFGVK
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 22344 Sequence Length: 197 Subcellular Location: Cytoplasm EC: 2.7.4.3
O29153
MIALGIEGTAWSLSIGVVDEEGVIALENDPYIPKEGGIHPREASQHHSERLPSLLSRVFEKVDKNSIDVVAFSQGPGMGPCLRVVATAARLLAIKLEKPLVGVNHCLAHVEVGRWQTGARKPVSLYVSGGNSQVIARRGNRYRVFGETLDIGIGNALDKLARHMGLKHPGGPKIEELAKKGQKYHFLPYVVKGMDFSFSGMVTAAQRLFDSGVRMEDVAFSFQETAFAMLTEVTERALAYLDLNEVLLVGGVAANKRLQEMLRIMCEDRGAKFYVPPKELAGDNGAMIAYTGLLMYKHGHQTPVEKSYVRPDFRIEDVEV...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcar...
Q4WDE9
MIAIGLEGSANKLGVGIMLHPEDGSTPRVLANIRHTYVSPPGEGFLPKDTARHHRSWVVKLVKRALREARISVRDVDCICFTKGPGMGAPLQSVAVAARMLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVDLPYTVKGMDCSFSGILAAIDGLAASYGLNGEEKEEEGAGDDSKPTRADLCFSLQETVFSMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAG...
Cofactor: Binds 1 divalent metal cation per subunit. Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbam...
Q5A6A4
MVVDLDKYLKPGKDHYLALGLEGSANKLGVGVIKHNKGPLSSTNRAEVLSNIRDTYITPPGEGFLPRDTARHHRNWVVRIIKQALATAKIAGKDIDVICFTQGPGMGAPLQSVVIAARTLAQLWNIPIVGVNHCVGHIEMGREITGAENPVVLYVSGGNTQVIAYSKQRYRIFGETLDIAIGNCLDRFARTLKIPNEPAPGYNIEQMAKKGKHLVPLPYTVKGMDLSMSGILAAIDSIAKEMFGKQQKKLIDEESGEPITAEDLCFSLQETLFSMLVEITERALAHVDSNQVLIVGGVGSNQRLQEMMKLMIQDRKNGQI...
Cofactor: Binds 1 divalent metal cation per subunit. Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbam...
Q8SQQ3
MIAMGLEGSANKLGVGIMRDDEILANERLTYAPPPGEGFIPVKTAEHHRSRILGLVAVSLEKAGVDLDDVDIFCYTKGPGMGLPLSVVATVARTLSLYCNKPLVPVNHCIAHIEMGRFITKASNPVILYASGGNTQIIAYHNRRYKIFGETLDIAVGNCIDRFARALKLPNFPAPGLSVERYAKLGKNYIELPYVVKGMDVSFSGILSNIKRKIAEDEQVKRDLCYSLQETVFSALVEVTERAMAFSSSKEVLIVGGVGCNLRLQEMMGIMARERGGVCYATDERFCIDNGVMIAYVGMLMAKSGAAFKLGECFVTQRYR...
Cofactor: Binds 1 divalent metal cation per subunit. Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbam...
P86244
SLRECELYVQKTDSREDEISPPPPNPVVKRGAISAEVYTEEDAASYVRNVLFSHLDDNERILMGSTLRMYEEFLSKVSILESLDKLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRVLGPCSDILKR
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. PTM: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. Sequence Mass (Da): 18794 Sequence Length: 167 Subcellular Location: Cell...
P31321
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGP...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. PTM: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. Sequence Mass (Da): 43073 Sequence Length: 381 Subcellular Location: Cell...
P00515
MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQ...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). PTM: A second phosphorylation site has not been located. Sequence Mass (Da): 45094 S...
P13861
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDG...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 45518 Sequence Length: 404...
P05207
SGSQDLEPSSGLVTDAIADSESEDDEDLDVPIPSRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERTVKVDEHVIDQRDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMY
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 17706 Sequence Length: 155...
P12368
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLREARRQESDSFIAPPTTFHAQESSGVPVIEEDGESESDSDDEDLEVPIPSKFTRRVSVCAETFNPDEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSDGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSKTKTNKNGGNQ...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 45480 Sequence Length: 401...
P31322
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQEENERKGTARFGHEGRTWGDAGAAGGGGTPSKGVNFAEEPRHSDSENGEEEEEEAADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGE...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 46336 Sequence Length: 418...
P31323
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGE...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 46302 Sequence Length: 418...
P31324
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVK...
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. PTM: Phosphorylated by the activated catalytic chain. Sequence Mass (Da): 46167 Sequence Length: 416...
A4QUT2
MHASLSSWLLAASLLTQPISVSGQGCPFAKRDGTVDSSLPQKRADAPETTTFGRCAVKSNQAGGGTRSHDWWPCQLRLDVLRQFQPSQNPLGGDFDYAEAFQSLDYEAVKKDIAALMTESQDWWPADFGNYGGLFVRMAWHSAGTYRAMDGRGGGGMGQQRFAPLNSWPDNQNLDKARRLIWPIKQKYGNKISWADLMLLTGNVALENMGFKTLGFGGGRADTWQSDEAVYWGAETTFVPQGNDVRYNNSVDINARADKLEKPLAATHMGLIYVNPEGPNGTPDPAASAKDIREAFGRMGMNDTETVALIAGGHAFGKTH...
Cofactor: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer. Function: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early s...
A0QXX7
MSSDTSDSRPPNPDTKTASTSESENPAIPSPKPKSGAPLRNQDWWPNQIDVSRLHPHPPQGNPLGEDFDYAEEFAKLDVNALKADLTALMTQSQDWWPADYGHYGGLFIRMSWHSAGTYRIHDGRGGGGQGAQRFAPINSWPDNVSLDKARRLLWPIKQKYGNKISWADLLVFTGNVALESMGFKTFGFGFGREDIWEPEEILFGEEDEWLGTDKRYGGGEQRQLAEPYGATTMGLIYVNPEGPEGQPDPLAAAHDIRETFGRMAMNDEETAALIVGGHTFGKTHGAGDASLVGPEPEAAPIEQQGLGWKSSYGTGKGPD...
Cofactor: Binds 2 heme B (iron-protoporphyrin IX) groups per tetramer. Function: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. PTM: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not...
A6T9H9
MSTSNDPSNNASAGKCPFHAETPKQSAGSGTANRDWWPNQLRVDLLNQHSNRSNPLGENFNYREEFKKLDYSALKADLRALLTDSQEWWPADWGSYIGLFIRMAWHGAGTYRTVDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPVKQKYGQKISWADLYMLAGNVALENAGFRTFGFGAGREDVWEPDLDVDWGDEKEWLAHRHPESLAKQAIGATEMGLIYVNPEGPNASGEPLSAAAAIRATFGNMAMDDEEIVALIAGGHTLGKTHGAAETSHVGAEPEAAPLEAQGLGWHSSYGSGAGADAITSGLEVVWTQ...
Cofactor: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer. Function: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. PTM: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme. Catalytic Activity: AH2...
P84744
VGCEECPMHCKGKHAVPTCDDGVCNCNV
Function: Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=145 nM), Kv1.2/KCNA2 (IC(50)=2.5 nM), and Kv1.3/KCNA3 (IC(50)=15). Also inhibits calcium-activated potassium channels (KCa/KCNN). Sequence Mass (Da): 2949 Sequence Length: 28 Domain: Has the structural arrangement of an alpha-helix connected to a bet...
P83406
VGCEECPAHCKGKNAIPTCDDGVCNCNV
Function: Calcium channel activator. Rapidly and reversibly activates ryanodine receptor 1 (RYR1). Sequence Mass (Da): 2880 Sequence Length: 28 Domain: Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). Subcellular Location: Secreted
P0C8X7
KRKCGLCKYRCCSGG
Function: May block voltage-gated potassium channels (Kv). PTM: Contains 4 disulfide bonds. Sequence Mass (Da): 1662 Sequence Length: 15 Subcellular Location: Secreted
P86121
GWINEEKIQKKIDEP
Function: Has antimicrobial activity against S.aureus (78% growth inhibition at 1.8 uM). PTM: Contains 3 disulfide bonds. Sequence Mass (Da): 1827 Sequence Length: 15 Subcellular Location: Secreted
Q2HR82
MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPPYPRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQALEEKDAQLCFLAARLEAHKEQIIFLRDMLMRMCQQPASPTDAPLPPC
Function: Plays a role in viral gene regulation and seems to be essential for KSHV reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host...
Q8SS96
MTTEIRNIKLVQKIASGAFGDIFIGQNTVTNQTVAVKLEKKAHYGQLKHEYGVYKALGGTRTPRIYEYGKILYENVYVNGLVMELMGKSLEQLFVTCSRRFSLKTVLMLGERMVDNVEYLHHRNYVHRDIKPDNFVFDVQGDRLYLIDYGLAKEFRNPMTFKHREMRTDKSLTGTARYASLRTHQGYEQSRRDDLESVGFCMVYFLKGRLPWQGLKAKTKQEKYDRIRESKESISLYELCMGLPKEIHSFCFYVRNLGYEDMPNYAYLRTLLSDALRQRGLRSDGVFDWMVRTPSDSMGDLEIL
Function: Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays (By similarity). Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 35525 Sequence Length: 304 Subcellular Location: Nucleus EC: 2...
P23291
MSMPIASTTLAVNNLTNINGNANFNVQANKQLHHQAVDSPARSSMTATTAANSNSNSSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSL...
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. PTM: Palmitoylated by AKR1. Location Topology: Lipid-anchor Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 61715 Sequence Len...
Q8SQR2
MRGEIMDYTICREIGKGGFGKVYEVKKKADQKSYALKIETNAPKAGRNSIINEIQAYSELQGCEKIPRLVDHGSYEGLTFLVLPLLKYSLKDLLERHPRFFTKKSATIVGKKLLNAIEFIHGKGRLHRDIKPENVMFGHNNRIYLVDFGMSAPYLRGDGSHIPEVGGKSVSGTLWYMSINTHRGIEQSRRDDLESLFYLLILLYKSRLPWMEPGASVSKKQEARTKEIKENLSVYDLCDGIHGKEHLIKFFQHISSLEFAEKPNYRYLNSLLDKIFHSNKELQGYKRAPKKEDTGLIRTSLWHKFISILSPFEVKYDG
Function: Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays (By similarity). Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 36589 Sequence Length: 318 Subcellular Location: Nucleus EC: 2...
P23292
MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRY...
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. PTM: Palmitoylated by AKR1, which is required for proper plasma membrane localization of YCK2. Location Topology: Lipid-anchor Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) +...
P39962
MSQRSSQHIVGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRDEFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSINTHFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIGMTKQKLNPDDLLLNNAIPYQFATYLKYARSLKFDEDPDYDYLISLMDDALR...
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Location Topology: Lipid-anchor Sequence Mass (Da): 60261 Sequence Length: 524 Domain: The YXXZ (T...
Q9JM63
MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSAS...
Function: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as e...
Q14654
MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVA...
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the vol...
Q61743
MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVA...
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the vol...
F1NHE9
MTAGRVNPYSIVSSEEDGLRLTTMPGINGFGNGKIHTRRKCRNRFVKKNGQCNVEFTNMDDKPQRYIADMFTTCVDIRWRYMLLLFSLAFLVSWLLFGLIFWLIALIHGDLENPGGDDTFKPCVLQVNGFVAAFLFSIETQTTIGYGFRCVTEECPLAVFMVVVQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVAMRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRITEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEINEDSPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLASE...
Function: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow in...
Q14500
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANE...
Function: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle t...
O60928
MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDK...
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to...
Q9UNX9
MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSY...
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to...
E1BNE9
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQSEQFEIVVILEGIVETTGMTCQARTSYTEDE...
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised...
P48549
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDE...
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised...
P63250
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDE...
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised...
P48050
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEP...
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to...
P48051
MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQ...
Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltag...
P56696
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGS...
Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorin...
Q9JK96
DRIRISISQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSAEEGPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPS
Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 18845 Sequence Length: 168 Domain: The segment S4 is probably the voltage-...
Q9NR82
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPL...
Function: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitabilit...
Q9JK45
MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTP...
Function: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitabilit...
Q96KK3
MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL...
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 . Location Topology: Multi-pass membrane protein ...
O35173
MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVARPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMR...
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 . Location Topology: Multi-pass membrane protein ...
A7GN34
MDKRISIAIDGPAAAGKSTVAKVVAKQLSYVYIDTGAMYRTLTYAALEQNIDIENEEKLMEVLQSIRIEFQQGKDTQQVFLNGQDVSEVIRTPDVTNRVSIVAKHRLVREEMVRRQQELAAQGGVVMDGRDIGTHVLPNAEVKIFMLASVEERAERRHLENMRKGFSSNLEQLKKEIAQRDKLDSEREVSPLKKAEDAFELDTTSLSIEEVVRNIMAIVSEALQK
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25386 Sequence Length: 225 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q5L9K4
MKKITIAIDGFSSCGKSTMAKDLAKEIGYIYIDSGAMYRAVTLYSIENGIFHGDTIDTDELKRRIGDIHISFRIDPETGRPNTYLNGVNVENKIRTMEVSSKVSPISALGFVREAMVAQQQEMGKAKGIVMDGRDIGTTVFPDAELKIFVTASAEIRAQRRYDELKAKGQETGFEEILENVKQRDHIDQTREVSPLKKADDALLLDNSHLTIAEQKEWLMAEYQKAIKA
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25649 Sequence Length: 229 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q65I08
MEKKLCIAIDGPAAAGKSTVAKIVARKKSYIYIDTGAMYRAITYLALEKGVDLNDEAALTALLKESAIDLTVSPEGEQKVYIAGEDVTEAIRTDSVSNQVSIVAKYAGIREEMTKRQQQLAEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRFEENVKKGYNVNYETLAEEIRRRDKLDSEREISPLKKADDALEIDTTSLTIDEVAEKILQIVDKKAQK
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25048 Sequence Length: 226 Subcellular Location: Cytoplasm EC: 2.7.4.25
P38493
MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITYAALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIAAKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEENVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEAVEQKSR
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25096 Sequence Length: 224 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q8A626
MKKITIAIDGFSSCGKSTMAKDLAREVGYIYIDSGAMYRAVTLYSIENGIFNGDVIDTEKLKEAIRDIRITFRPNPETGRPDTYLNGVNVENKIRTMGVSSKVSPISALDFVREAMVAQQQAMGKEKGIVMDGRDIGTTVFPDAELKIFVTATPEIRAQRRFDELKAKGQEGSFEEILENVKQRDYIDQHREVSPLRKADDALLLDNSNLSIEQQKEWLSEQFGKVVKE
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25759 Sequence Length: 229 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q83E10
MNARQKPAPVITIDGPSGSGKGTIAFRIAQTLNWYLLDSGIIYRAIAWAMAHYKVPLEDSAGLARLLKRVQISIENRILGKKAKISCDGHDITLAIRSEECGALASRASALPIVREAVLQYQRDFRQRPGLVADGRDMGTVVFPDAVLKFYFDADSQQRAYRRYKELQDRGINVSLPDIQEDLEERDRRDITRSISPTKPAEDAVIIDTTHLSIEAVFATVMNHVRQRGLANVANEK
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 26459 Sequence Length: 237 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q0KDH7
MTIVNVIAIDGPTASGKGTVAHKVADAVGFHLLDSGALYRLVALASDRAGIDLADVDALAKIASRLDVKFGPDRVWLQGEEVSLAIRAEAIGNRASAIAVHQPVRDALTQLQRSFRKLPGLVADGRDMGTVIFPDAPLKVFLTASVEARARRRYKQLIDKGISANIEDLLRDLEARDVRDRTRTAAPLRPAEDAKLLDTSDMTVDQAVAQVLEWFAAVRPDA
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 23969 Sequence Length: 222 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q6A8F7
MSTSPLVIAIDGPSGSGKSSTSRGVANRLGLARLDTGSMYRAVACRVAHLGIDPTTNPRDAIKVAQSCHLEIDTSAIDDRVVIDGEDVTKEIRDPQTSAKVSAVATIQPVRDALTARMRQVAADRGRIVMEGRDITTVVCPDAQVRVLLVADPAIRVARRQAELGEKVDMAQVIDSIVRRDRDDSTVSTFEEPAEGVTVVDSTHLNLDQVIDAVIDLVPVTLR
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 23916 Sequence Length: 223 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q11YY6
MKKIIVAIDGYSACGKSTTAKILAAKLGYVYIDTGAMYRSVALYFIQHYINSTNPKAVAEALNQIHISFVHNNKTETCETYLNGLNVESEIRKMYVSEKVSEVSAIPEVRKRMVELQQKMARKRGVVMDGRDIGTHVFPDAELKIFMVADMHVRAFRRQQELFERKQIIDLDDIIKNIESRDLMDTTREESPLRKASDAYEIDTTYITVEEQVDCIMNIAVGKMIELEYNIENI
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 26827 Sequence Length: 234 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q7ZWE9
MKPQVVFVLGGPGAGKGTQCARIVENYSYTHLSAGDLLREERSRTDSEFGQLIDSYIKEGKIVPVQITINLLRKAMEETMKADEKKFRFLIDGFPRNQDNLQGWNTEMDGKADVKFVLFFDCSNEVCIDRCLERGKSSGRTDDNRESLEKRIQTYLQSTRPIIELYEKQGKVQRIDASRSVDEVFADVKNILEKDD
Cofactor: Binds 1 Mg(2+) ion per monomer. Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase...
Q9RRE9
MIVTIDGVAASGKSSVSSGVARALGIPYVSSGLLYRAATLLGLEAALDLSDAPRLLAHLRALPLRLEPLAEGNRVWSGERDLTPGLHQSAVDAGVSTVAAHPELRAWVDEQLRQLPPPFVAEGRDMGTNVFPDAPAKFYLTASPRIRAERRSAERPEDVDAIEAALIARDRKDAAQSAPAPDARVIDTGPLGLEEVIGEILGEIGQ
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 21781 Sequence Length: 206 Subcellular Location: Cytoplasm EC: 2.7.4.25
A4J3N3
MTEHKCIAIDGPAGAGKSTVAKKVAQKLNLLYIDTGAMYRAVTLKALRERINLWDDIALIELAKRTIITLLAGQKQSVLLDGLDVTREIRTPEVTNNVSIVAKIAGVREVLVQRQREMAEEAGVVMDGRDIGTVVLPKAKAKFFLTASAEERARRRAKEMMNFGYDVDLEQLIKEIEERDFMDSNRAVSPLVPAEDAVLIDSSGMTIDEVVNSIITWVEKGK
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 24568 Sequence Length: 222 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q72DA1
MPDTTGGHPAALKVVTLDGPAGVGKTTLARRVADALGIPYLDTGAMFRTMAWRLGPDGPDLDEALLRDRLAGFVFTLRGRGGASVLSCNGEDIGNEIRTEEVGAMASRIAALPVVRECLKAAQQRMGAAQPLVVEGRDMGTVVFPGARHKFFLDAAPEIRAMRRYTQLQTMGEAHDLALLTEQIRSRDEQDRNRAVAPLRPAADAIIVDTGDLDIDGVFGVIMQHIRSRDGL
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 24955 Sequence Length: 232 Subcellular Location: Cytoplasm EC: 2.7.4.25
P20425
MMEKSKPNVVFVLGGPGSGKGTQCANIVRDFGWVHLSAGDLLRQEQQSGSKDGEMIATMIKNGEIVPSIVTVKLLKNAIDANQGKNFLVDGFPRNEENNNSWEENMKDFVDTKFVLFFDCPEEVMTQRLLKRGESSGRSDDNIESIKKRFNTFNVQTKLVIDHYNKFDKVKIIPANRDVNEVYNDVENLFKSMGF
Cofactor: Binds 1 Mg(2+) ion per monomer. The Mg(2+) ion binds to water and substrates. Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Cat...
Q7UEW6
MIITIDGPAGAGKSSIARRVASELGFEFLDTGAMYRAVTWGVMQQGIAWDDVESLVEFADAAQLIWQDDRIYLDNQDISEEIRTPQVTSHIRYLADPPRIRERITAQQRRIATGRDIVTEGRDQGTEVFPDAHCKIFLTASPEERARRRQRQLAENGRVMSVEEILAAQNQRDLEDRMRPVGRLRAASDAIVVQTDGMSPDEVREEVLRLVRECVQASAANSASSDVTR
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 25696 Sequence Length: 229 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q0SI81
MSTSKLVVAMDGPSGTGKSSVSRMLAQRLDARYLDTGAMYRIATLHALRKGVDLTDPAAIADATAGLPWSIGTDPAGEQVLLDGEDVGEEIRGDAVTKAVSAVSAVPAVRELLVAAQRRLAGEAERIVVEGRDIGTVVIPDADVKIYLTASAEARAQRRNAQNLAEGRGDDYAAVLADVQRRDHLDSTRAVSPLRPADDSVLVDTSELGIDDVIGRLLLVVSERTGAGQ
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 24066 Sequence Length: 229 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q2RXP6
MIIAIDGPAASGKGTLARRLATQLRFAYLDTGKLYRAVGMAVIKGGADPHDAKAALAAARALDPATLGDRLLSTDTAGKAASVVGAIPEVRAALLDLQRDFATHPPQGAPGAVLDGRDIGTVVCPEAEVKIFVTASVEVRAHRRLQELRSGGHDVKEDDVLRDMRERDARDSGRAVAPMAIAADAVVLDTSRMTAEQALTAALDILAHKSQKT
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 22305 Sequence Length: 213 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q9ZD27
MIDLKTKAFDIAQNFTISLDGPAASGKGTVGLILAKKFSLKYFQSSIVYRQLAFNCINQQIDITDIDAVIALSKELKLDNNIDLENEDIGDIASQIAVISDVRNNLNENLINLVKTTPRIIMEGRDIGTVVAPDADLKIFITASPYVRAIRRYNQLQAKGKTCILDEIIQQIILRDKRDKERKAGPLLPALGAFIIDTSKLSAIEIVEEVTNYIKNKIT
Catalytic Activity: ATP + CMP = ADP + CDP Sequence Mass (Da): 24319 Sequence Length: 219 Subcellular Location: Cytoplasm EC: 2.7.4.25
Q8NT57
MARFSPQDLADHLKDGLLSFPATAFQDDLEVDEAAYVEHIEWQSSYPVAGLFAAGGTGEGFSLTVEENHRVTQLAVQASSPEVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTECDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLSERYPNFIGFKDGTGNIEHLAKITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAAVKQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLLATSGAGSYRLPVEVKA
Catalytic Activity: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O Sequence Mass (Da): 33552 Sequence Length: 316 Pathway: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 2/2. EC: 4.2.1.41
B2RXH2
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDP...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Catalytic Activity: 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[...
Q9U297
MASAATTTHFPSSRIPSEPCASSGPLFPDDVLFTTEASSASSSSCHVENDSRPLSPTMFTDGRTPVNISAKHLKDHPLHEPTGTSEVLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEITQPARETIEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHGEPIYGADTEGSFYDAQVEEWNMNRLGTILEDTNYEIKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFLHFGAPKYWFAISSEHADRFERFMSQQFSYQNEYAPQCKAFLRH...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code . Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a ger...
Q81HP9
MEKKQSILSPIIRITFTFLVLCGLVYPLIVTGIAQAVMKDNADGSLIYNDKNEVIGSKLIGQNFTDPRYFQGRVSSIEYKAEASGSNNYAPSNPDLEKRVEKSIEEWKKQNPSVPVTEVPIDLVTNSGSGLDPDISPKAASVQVDRISKLTDIPKEKLNQLIKDQTEGAALGLFGETRVNVLKLNLALQELMK
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
Q8A521
MKTLFKSLKITLVFCVFFSVFYILILWLFAQVAGPNKGNAEVATLDGKVVGAANVGQMFTKDIYFWGRPSCAGDGYDASSSSGSNKGPTNPEYLAEVEARIDTFLVHHPYLSRKDVPAEMVTASASGLDPNITPQCAYVQVKRVAQARGLTENQVKEIVDQSVEKPLLGIFGTEKINVLKLNIALEENK
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
A4Z016
MLKEIRPAIFVLLALTLITGLLYPLAMTGLAVTIFPAQAAGSLITRNGQVIGSALIGQEFKDDRYFHGRPSATSTADPNDSTKTVPAPYNAANSSGSNLGPTSKALADRVKEDVDKLKAENPAQPVPVDLVTTSASGLDPHVSPEAAMFQVPRVAKARGVPEDRVRALVVKNTEGRLIGLLGEPRVNVLALNLALDAATATK
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
A6X5I0
MLKQLRPALVMIVSLTVITGLLYPLGMTGIAQVIFPANANGSLIEKDGTIIGSELIGQGFTGDRYFHGRPSAAGQNGYDAASSGGSNLGPTNPKLIERIKADATALSQDEGSARPPIDLVTTSASGLDPHISPETAFYQVPRVAKARGIDEAALREIVEQQVEARELGFLGEPVVNVLKLNLVLDRTSTK
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
Q9X8Z8
MNTSLTNAARLFTAGLRALLVLTVVTGIVYPLVVTGVAQGLFPGKANGSEIKADGKVVGSSLIGQSYNLPLKEGRETPEPDLRWFQGRPANGLGTNTVNTRYELILSGATNRSADDPELLQWVQDAKAAVVRDNSVPGHPVRPEDVPADAVTSSGSGLDPDISPRYADLQVHRVAAKNGLPAERVQELVDEHTTPRTLGFIGEPRVNVLELNIALVELVAPGAGH
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
P57688
MKSYLKALVFAVLFLFILGFVYPTVTSLITEHALPFQSEGQPVEIDGHIYGSYLLAEAFNSSFFFHPRPSAIDYNLSESGSYDYSLGNPAMLNLTEKYLHRFLSENPGVNISEIPYAMISYSGSGLDPGIPLQGAIIQIPRISIAIHNITNLSVSDLYSYLYNLVNSTKTQNFPFFGSYYVNVVRLNVDIVEFLLKGGYISQSQI
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
B3EAQ1
MKDIKPAILLFIMFTIICGGIYPALVTGIAHALFPDQAKGSLIIDKAGKELGSNLIGQPFSAPQYLWPRPSVTAEFGYNPSASGGSNSGQTNPDYLKTVAERVKTLRESGMTGLIPTELAQASASGLDPHLSPQAARLQAARIAKARGIPETAVQKLINENTAGPQLGILGAARVNVLAVNLKLDTLTR
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
Q8PPC8
MPLRDDGVLRGSLVLAVFTLFGLGLAYSLIATGITGALFSEQATGSLMRVDARVVGSALVAQPFTDARYFQPRPSAAKYDLTAAAGSNQARSNPDLLARIATTRAQVAARDGIAPEAVPGELLTQSGSGLDPHLSPAGAQVQIRRVAAARGWPEQRVAALVQATTEAAPQFGLLGQPRVNVLALNLALDQAGNGESGRGNGVKQAH
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...