ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q4UQV0
MSTSLPLRDDGAVRASFALALFVLLGLGLGYSLVATGITSALMPDQAHGSLLRADGRVIGSSLVAQPFADARYFQPRPSAAKYDPTAAAGSNQARSNPELLARIATARAEIAQRDGIAPDAVPGELLTQSGSGLDPHLSPAGAQVQLRRVAAARGWPEQRVAALLQAATEQPQFGLLGQPRINVLALNLALDRAGDGVPGTENGVEQQR
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the...
P94608
MDINYERPDPYYLLNKIDKEEKNKNRGKLKIFFGYAAGVGKTYAMLRAAHYMKELGKDIVIGYIEPHARMDTMSLTKGLPQIPVKNIDYKGVILREFDVDKALLRKPEIILVDELAHTNAKSQRNKKRWKDIEELLDAGIDVYTTLNVQHIESLNDIVANITHVSVRETIPDKVFDDADKVELIDIEPDELLKRFTDGKIYRKEQVKRAFNNFFTKNNLYALREIALRRTADRVNFEIEIARLSKGQITVMATSDQILACIGTSPSSARIIRTAARMAESYHSKWIALYVDTGRSLGKADKETLNANFNLVELLGGELVT...
Function: Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals (By similarity). Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho...
P21865
MNNEPLRPDPDRLLEQTAAPHRGKLKVFFGACAGVGKTWAMLAEAQRLRAQGLDIVVGVVETHGRKDTAAMLEGLAVLPLKRQAYRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDIEELLEAGIDVFTTVNVQHLESLNDVVSGVTGIQVRETVPDPFFDAADDVVLVDLPPDDLRQRLKEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDEQMRAWRGHPGEEKVWHTRDAILLCIGHNTGSEKLVRAAARLASRLGSVWHAVYVETPALHRLPEKKRRAILSALRLAQELGAETATLS...
Function: Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Lo...
P61656
MKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIFKSSFDKANRSSVNSYRGPGLAEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQIPAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVKMNESGNNKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGIFMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL
Catalytic Activity: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate Sequence Mass (Da): 31703 Sequence Length: 287 Pathway: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: s...
Q604M5
MSNVETSARPFELCGFPVGLEHPLFLIAGPCVIETEQLALDTAGALKEITDGLGIPFIYKSSFDKANRSSHASYRGPGMEEGLRILAEVKRQIGVPVLTDVHEDTPLQEVASVVDVLQTPAFLCRQTNFIQNVANTGKPVNLKKGQFLAPWDMKHVAAKALATGNRHIMVCERGVSFGYNNLVSDMRSLSIMRETGCPVVYDATHSVQLPGGQGTASGGQREFVPALARAAVAVGISGLFMETHPDPDRALSDGPNSWPLDRMKALLELLSTLDRTVKASPLL
Catalytic Activity: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate Sequence Mass (Da): 30506 Sequence Length: 283 Pathway: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: s...
Q9JZ55
MDIKINDITLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEKVKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKLILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPDPKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE
Catalytic Activity: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate Sequence Mass (Da): 30483 Sequence Length: 280 Pathway: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: s...
Q3SRK0
MNQPVSASPVVSVGSVTFGQDRPLSIIAGPCQMESRAHALEVAGALKDIAARLNVGLVFKTSFDKANRTSASGARGIGLKQALPVFADIRSSLGLPVLTDVHEAAQCAEVAQVVDVLQIPAFLCRQTDLLLAAAATGKVVNVKKGQFLAPWDMGNVVAKITGGGNRNILVTERGASFGYNTLVSDMRALPILARTTGAPVIFDATHSVQQPGGKGASTGGEREFVPVLARAAVAVGVAGVFIETHPDPDHAPSDGPNMVPLREFEALVRRLMAFDALAKAADPACPE
Catalytic Activity: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate Sequence Mass (Da): 29822 Sequence Length: 287 Pathway: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: s...
O66914
MRRAVIIPARLGSTRLKEKPLKNLLGKPLIRWVVEGLVKTGERVILATDSERVKEVVEDLCEVFLTPSDLPSGSDRVLYVVRDLDVDLIINYQGDEPFVYEEDIKLIFRELEKGERVVTLARKDKEAYERPEDVKVVLDREGYALYFSRSPIPYFRKNDTFYPLKHVGIYGFRKETLMEFGAMPPSKLEQIEGLEQLRLLENGIKIKVLITENYYHGVDTEEDLKIVEEKLKNL
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27173 Sequence Length: 234 Pathway: Nucleotide-suga...
Q9C920
MSVCSSSSSSQKTWIVNGILAGTAIAAAIGARAYLGRSKKFRSRVVGIIPARYASSRFEGKPLVQILGKPMIQRTWERSKLATTLDHIVVATDDERIAECCRGFGADVIMTSESCRNGTERCNEALEKLEKKYDVVVNIQGDEPLIEPEIIDGVVKALQVTPDAVFSTAVTSLKPEDGLDPNRVKCVVDNRGYAIYFSRGLIPYNKSGKVNPDFPYMLHLGIQSFDSKFLKVYSELQPTPLQQEEDLEQLKVLENGYKMKVIKVDHEAHGVDTPDDVEKIESLMRERNMS
Function: Catalyzes the production of the sugar nucleotide CMP-3-deoxy-D-manno-octulosonate (CMP-KDO). CTP is the preferred nucleotide donor, but it can partially be replaced with UTP. Activates KDO during the biosynthesis of rhamnogalacturonan II (RG-II), a structurally complex pectic polysaccharide of the primary cel...
A8IGU8
MAFSASDVLVLIPARLAASRLPGKPLADVGGRPMIVEVARRAVAAGIGRVAVATDAVEIADAVRAAGFEAVMTRADHPSGSDRIFEALGVLDPDGAVQVVVNVQGDLPTIAPETIRAALVPLEEGPADIATLTAVITEEGERTDPNVVKVVGTPIGENRLRALYFTRATAPTGEGPLYHHIGLYAYRRAALERFVSLPPSPLEKRERLEQLRALEAGMRIDVAVVDAVPLGVDTPEHLERARALLASNDN
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 26436 Sequence Length: 250 Pathway: Nucleotide-suga...
Q8A9S0
MKFLGIIPARYASTRFPAKPLAMLGGKTVIQRVYEQVAGILDDAYVATDDERIEAAVKAFGGKVVMTSIDHKSGTDRCYEACTKIGGDFDVVVNIQGDEPFIQPSQLNAVKACFEDPTTQIATLVKPFTADEPFAVLENVNSPKVVLNKNWNALYFSRSIIPFQRNADKEDWLKGHTYYKHIGLYAYRTEVLKEITALPQSSLELAESLEQLRWLENGYKIKVGISDVETIGIDTPQDLKHAEEFLKNRS
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27994 Sequence Length: 250 Pathway: Nucleotide-suga...
Q6G4U6
MALEPIILIPARIGSTRLPQKALAEIAGKPMIVHVAEQAKKAAFGRIIVATDHNNIAKVVTAYGHECIITCRDHKSGSDRIYEALTHIDPERRYNVILNVQGDLPTITPHEIISALRPLENSLTDIATLGAKIVEENEKTDPNIVKIIGTPLSHNRFRALYFTRATAPYGDGPLYHHIGIYAYRREALEKFVALKPSPLEQREKLEQLRALEHNMRIDVEIVDTIPLGVDTQRDLERVRKILA
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27280 Sequence Length: 243 Pathway: Nucleotide-suga...
Q6MPP1
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAEAVGVKVVMTDSDLPTGSDRINAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKMDMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPYSRMSAQEAGSMDGCLKHIGMYAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEKLLSSQGM
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 26921 Sequence Length: 247 Pathway: Nucleotide-suga...
Q492T2
MNFVVIIPVRFFSTRFPGKALADINGKPMIVRVMENALDSGANKVIIATDSSCIARVIESEQSESEVCLTRSTHQSGTERLAEVAINYKFSDDQIIVHLQGDEPLLSSTMIRQVASILCSMSSTISMATLATPLSSFKEARDDNVVKVVINMNSNALYFSRSMIPWNTGDFVNHLDSKFSKTLLRHIGIYAYRVKFLRRYIAWTKSPLEQIEHLEQLRVLWHGEAIHVSVIDDVFNISVDTPESLSRVNTVFKKNKYATVHN
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 29527 Sequence Length: 262 Pathway: Nucleotide-suga...
Q129C7
MRFTVLIPARLASTRLPNKPLADMGGAPMVVRVAQRAMQSTAARTVVATDSTDIIDKCAAFGVAAVLTRADHPSGSDRLAEACTALGLADDDIVVNVQGDEPLIDPALIDAVARLLNERPDCAMSTAAHSIDQMADLLNPNVVKVVLDARQTALYFSRSPIPAARDFAGKPWWEDGEKGCKLPKPLRHVGIYGYRVGFLRQFPTLPQAPLEQLESLEQLRALWHGHRIAVHITDEAPGPGVDTPEDLARARQFFP
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27656 Sequence Length: 255 Pathway: Nucleotide-suga...
B2RLM4
MNTEVIAIIPARFASSRFPGKPLADMLGKSMIQRVHERIAGVVPRAVVATDDERIRQAVEDFGGEVVMTSPECSSGTERCREAFDKVGRGEKIVLNLQGDEPFIQKEQIDLLISAFDKPETDIATLAEVFSSDASFERLNNPNSPKIVLDHGGYALYFSRSVIPYLRGVQPDSWCRRHTYYKHIGIYAFRPTVLRKITSLPQSTAEQAESLEQLRWLEYGYRIRVLQTQQSTIGIDTPEDMDKAIAYLRSQGME
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 28660 Sequence Length: 254 Pathway: Nucleotide-suga...
Q9HZM5
MTQAFTVVIPARYASTRLPGKPLQDIAGQPMIQRVWNQARKSAASRVVVATDDERILAACQGFGAEALLTRAEHNSGTDRLEEVASRLGLASDAIVVNVQGDEPLIPPALIDQVAANLAAHPEAAIATLAEPIHEVSALFNPNVVKVATDIDGLALTFSRAPLPWARDAFARDRDSLPEGVPYRRHIGIYAYRVGFLADFVAWGPCWLENAESLEQLRALWHGVRIHVADARENMLPGVDTPEDLERVRRVLGG
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27646 Sequence Length: 254 Pathway: Nucleotide-suga...
Q4KFT3
MSSAFTVVIPARYASTRLPGKPLQLIAGKPMIQWVWEQARKSSAERVVVATDDQRIVEACQGFGAEALLTREDHNSGTDRLAEVAAQLGLAADAIVVNVQGDEPLIPPSVIDQVAANLAAHTEARMATLAEPIEDVQTLFNPNVVKVVSDLNGLALTFSRATLPWARDAFAQSREQLPEGVPYRRHIGIYAYRAGFLHDFVSWGPCWLENTESLEQLRALWHGVRIHVADALEAPPTGVDTAEDLERVRRLLEA
Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. Catalytic Activity: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate Sequence Mass (Da): 27862 Sequence Length: 254 Pathway: Nucleotide-suga...
Q46222
MMLRGVHRIFKCFYDVVLVCAFVIALPKLLYKMLVYGKYKKSLAVRFGLKKPHVPGEGPLVWFHGASVGEVRLLLPVLEKFCEEFPGWRCLVTSCTELGVQVASQVFIPMGATVSILPLDFSIIIKSVVAKLRPSLVVFSEGDCWLNFIEEAKRIGATTLVINGRISIDSSKRFKFLKRLGKNYFSPVDGFLLQDEVQKQRFLSLGIPEHKLQVTGNIKTYVAAQTALHLERETWRDRLRLPTDSKLVILGSMHRSDAGKWLPVVQKLIKEGVSVLWVPRHVEKTKDVEESLHRLHIPYGLWSRGANFSYVPVVVVDEIG...
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Thus generates the genus-specific LPS epitope of Chlamydia, composed of the trisaccharid...
P0CE14
MIRRWLTSRLYDAFLVCAFFVSAPRIFYKVFFHGKYIDSWKIRFGVQKPFVKGEGPLVWFHGASVGEVSLLAPLLNRWREEFPEWRFVVTTCSEAGVHTARRLYESLGATVFVLPLDLSCIIKSVVRKLAPDIVIFSEGDCWLHFLTESKRLGAKAFLINGKLSEHSCKRFSFLKRLGRNYFAPLDLLILQDELYKQRFMQIGISSDKIHVTGNMKTFIESSLATNRRDFWRAKLQISSQDRLIVLGSMHPKDVEVWAEVVSHFHNSSTKILWVPRHLEKLKEHAKLLEKAGILFGLWSQGASFRQYNSLIMDAMGVLKD...
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Thus generates the genus-specific LPS epitope of Chlamydia, composed of the trisaccharid...
P0AC77
MLELLYTALLYLIQPLIWIRLWVRGRKAPAYRKRWGERYGFYRHPLKPGGIMLHSVSVGETLAAIPLVRALRHRYPDLPITVTTMTPTGSERVQSAFGKDVQHVYLPYDLPDALNRFLNKVDPKLVLIMETELWPNLIAALHKRKIPLVIANARLSARSAAGYAKLGKFVRRLLRRITLIAAQNEEDGARFVALGAKNNQVTVTGSLKFDISVTPQLAAKAVTLRRQWAPHRPVWIATSTHEGEESVVIAAHQALLQQFPNLLLILVPRHPERFPDAINLVRQAGLSYITRSSGEVPSTSTQVVVGDTMGELMLLYGIAD...
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Catalytic Activity: CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kd...
P44806
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAASTHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGI...
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the...
Q9ZE58
MMLLYYTLSFILLPVYFIIIFIRLLIGKEDIRRIQERFAIGKQRQNSALDFIQMSVNKEGFTDHKTTSYVDMHRNASLMYKLSLERSYAHSLVWIHAASVGEVMTALTLIHNISKLAPNVRFLITSWTNASAKILSTKLPKIATHQFLPIDNVIFTRKFLRNWQPDLGIFIESELWPCTINEGAKYCKLLLINARISNKSFKAWLKRKRFFQLIIKNFSKIIVQSERDLQKFNALGISDAMNLGNIKFANEKLLVNQEKLSKLILHLDNRRVLVFASTHPEDEEVILPIINNLKEQFIDCYIILIPRHPERIKSIINNCK...
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Catalytic Activity: CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-...
P50842
MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSHTSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREKAEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYTASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGRWGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR
Function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH. Catalytic Activity: 2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + N...
P37769
MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPALLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR
Function: Catalyzes the reversible reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH (Ref.4). To a lesser extent, can also reduce 5-keto-D-gluconate and oxidize D-gluconate and 1,2-pro...
Q8A2S4
MKTNYEIRYAAHPEDAKSYDTARIRRDFLIEKIFVPNEVNMVYSMYDRMVVGGALPVGEVLTLEAIDPLKAPFFLTRREMGIYNVGGPGVVKAGDAVFELDYKEALYLGSGDRVVTFESKDASNPAKFYFNSLTAHRNYPDRKVTKADAVVAEMGSLEGSNHRNINKMLVNQVLPTCQLQMGMTELAPGSVWNTMPAHVHSRRMEAYFYFEIPEEHAICHFMGEVDETRHVWMKGDQAVLSPEWSIHSAAATHNYTFIWGMGGENLDYGDQDFSLITDLK
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Catalytic Activity: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate Sequence Mass (Da): 31666 Sequence Length: 280 Pathway: Glycan metabolism...
Q9X756
MDSHTLIQALIYLGAAALIVPIASVLGLGSVLGYLIAGCIIGPWALRLVNDAEAILHFAEIGVVLMLVAMGLELDPQRLWKLRASVFDGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAIPLVAMIPLLAASGGATSLMAFALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVACSWSSALGLLLEEVGLSMAMGAFLAGVLLASSEYRHALENDIEPVKGLLLGLFFIGVGMSIDFAPWSPNPLRIVILLVGFPAIKMLMLWLIAQPLGV...
Function: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 67353 Sequence Length: 621 Subcellular Location: Cell inner membrane
Q8ZRW2
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGV...
Function: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 67054 Sequence Length: 620 Subcellular Location: Cell inner membrane
E7R7R2
MSRYFLLACTLALQCVAASQEDYIVKDLPGLSNIPAVVRPVMHAGHLEIDEEHNTELFFWRFQNPKNNGTHQTLHRNELIVWLNGGPGCSSMDGAMMETGPLRVSDKLEVELNPGSWTQVADILFVDQPAGTGFSYTDSYDTELKQAAQHFWQFLKTYYQLFPEDRTKKLYLAGESYAGQYIPYFAKEIIENNSLNISLEGLLIGNGWIDPDIQSLSYVPFSLEAGFLDRQSPSMAQVLKQHEKCQQAIDDPSNHDFEKVECVKIFHSILAASRDETKPAKEQCVNMYDYRKHDYFPACGSNWPEGLPTVTKFLNLDAVQ...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
B6H7A4
MLLSALSLLLSPLVSASSAADYYVRSLPGAPEGPFLKMHAGHIEVDPDTNGNLFFWHFQNRHIANRQRTVIWLNGGPGCSSMDGAFMEVGPYRLQDDHTLKYNEGRWDEFANLLFVDNPVGTGFSYANTNSYLHELDEMAAHFVIFLEKFFELFPEYANDDLYIAGESYAGQHIPYIAKAIQDRNKGITENGGTKWPLKGLLIGNGWISPADQYPSYFKFIEREGLAKPGTSLHHNINALNEVCLSKLETPGAKNKLDVGACELVLQQFLDLTTEDHQCYNMYDVRLKDEAKSCGMNWPPDLKNIEPYLQRPDVVKALNI...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
Q0USX0
MLLTHTSSRWRTAAVCALAATASWLPSVQAAEKTQADYFVSSLPGAPEGPLLKMHAGHIEVDAEHNSNLFFWHYENRHIADRQRTVLWLNGGPGCSSMDGAMMEIGPYRVKHGGHLEYNNGSWDEFANMLFIDQPVGTGFSYVNTDSYLTDLDQMAEHMMIFLEKWFKLFPEYENDDLYIAGESYAGQHIPYIARAILNRNKNQNTDPKPWNLKGLLIGNGWISPADQYLAYLPFAYQNGMIQADSDSAKRVEQQQSICIQKLQDGGHDKVDTSECEQIMVAILEETKDRKADRMNQCLNMYDIRLRDDSSCGMNWPPDL...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
D0MVS1
MVTRHVLAAALAGSMTSAQRLHPTSQRASDDLIQNLPGLDPAAKVTQHAGRIALHDNDKNKMFYWHFQAAQDPEKAPLVIWLNGGPGCTSMQGLFLGNSPFTLKDDSTIGKNEHSWHEFANLLFVDQPIGTGMSYTKGNDYRLDEETIAQDFYEFLTKFLQRHNKYLSDGDDGVSNSRAVYMFGESHAGRWIPEFSDHIMKQNNDPKNQIKINLDGVGIGNGWVHPRIQYEYSDYAHGLGLLTFGQVRSLKASYAECLAALDAGTYYSRSCLDNMDSITGSVKPGNGGNSLNFYDVRQYLRNVGSYPSGQSNIAKYMNKM...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
E3L8A5
MSSFQSATTRQGLHRRNMNSETPQSEFIQRLRRSPPSESSSSTPSSSTTTSSTTTTSNTSGKKKKTAPSASDFYVPSLPGQPKDSQLILYAGHLSFSPPDTTIEPEKDSYGFFFLNKARHIANRPVLLVWLNGGPGCSSFDGSLMEVGPLRMVLKGDGTLKEVDAAWNEYANMLFIDQPTGTGYSYGPKPNYVHELDVSSANLVNLLARFFKIFPEYQQMDLYICGESFAGQYIPYLAQAILDTNIISAPLKGIMIGNGWIDPINQYLAYPEFAFKVGLVNPSSKAADLVNEELKKCTEWIDSNSTTPIHIEACEGILSA...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
B6K7U7
MSLSFLLRVAGLFFLQFNSAQAKSQVHEQWHVSSIPNVPAGYTGSLHSGYLNLTDKLEGDLFFTLYGSENEVHQNRTIIWLNGGPGCSSEDGSMLELGPLRLTNDSLVYYNAASWVRLGNVLFVDQPMGTGFSFADTRDAILNDNEKMSNDFAYFLQEFVKAFPEYATDTWYIAGESFAGQYIPAIAKKVIDSDIVNLSGIAIGNGWIEPASHYLTYLDYLVERGLLERGSALFEALTAVQAKCLMSLEQSASGMLEDENSCDKYLFDILFSVSDKSGEFCFNMYDVTLTSPYPSCGMEWPLELPALTDFLSSPDVMKAL...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
O60123
MISKLLKIVLLTAGVIGNTLADSRIHEQYLVKAFPNEPVDYEGRMHAGHLNQTDQLDGDLFFWMFESVKPEYEHRSILWLNGGPGCSSEDGSLMEVGPFRLDDNNTFQLNPGRWDELGNLLFVDQPLGTGYSYSLAKDFQSNNEKMANDFSIFFEKFLEEFPERANDEWFIAGESFAGQYIPHIAAKLKEKNLVNLGGLAIGNGWINPLSHYETYLNYLVEKGMVDFESELGQYLHHSWAECLLAFDKIGSGSGDLSKCESFLGDILYMVSKEPGKACMNMYDISLESTYPTCGMDWPYDLSYLTEFLSTREAMTSLNVN...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
A7EYY7
MRSLTTKTSSALLTVWGLLSVSLMPSVGQADKTAGDYFVHSLPGAPAGPLLKMHAGHIEVTPEHHGNIFFWHFQNRHIANKQRTVIWLNGGPGCSSEDGALMEIGPYRVKDGSNGPKLEYNPGSWDEFANVMFVDNPVGTGFSFVDSDSYIHDLPEMADQFVQFLEKWFALFPEYEHDDLYLAGESYAGQHIPYITKAILERNKKPDAKHKWPVKGMLIGNGWISPVEQYMSYLPFAYEKGLVKKDSEKAKKLESQQAICTKMLNENGGRDKVDNSQCEQILQEILSTTQSKGSDGNMQCYNMYDVRLKDSYPSCGMNWP...
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). Catalytic Activity: Preferential release of a C-terminal arginine or lysine res...
Q9PNB8
MKLQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEFQKGIDSDHFLEWARVHENFYGTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSVFITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELSEYDYLIINDELKQSYEALRAILIAHKFRTKGQNLGQIQNIWNEGE
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 24025 Sequence Length: 207 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q3AC14
MHKGMLVVVSGPSGAGKGTICQEIRKRNPNLFYSISATTREKRVGEIDGVHYYFIDRQQFEKMIANDEFLEWADVYGNYYGTPKKPVFEALARGQDVILEIDIKGARQVKKTYPEGVFVFILPPSISILEERLRKRGTDKEEIIVKRMQMAWEEIANCDWYDYLILNDDLETAVNDLEAVLTAEKLKPKRVNYRVLLEGGVLER
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23494 Sequence Length: 204 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q9A7N9
MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHFVSRDKFQGMLAEDAFLEWAEVYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAGADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKDEVAAWEQFDYVILNDDFDRAYADLAHIYHAERLKRARNPWIGDLVSDLLKEEI
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 24219 Sequence Length: 213 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q3J2A5
MARRGLLLILSSPSGAGKSTLSKRLTAWDPSIRFSVSATTRAPRPGEVDGRDYYFRTRDEFIAAVEAGEMLEHAEVFGNFYGSPKAPVEKALEQGHDTLFDIDWQGGQQIRNSSLGRDVVSIFVLPPSIGELDRRLRSRAQDSEEVIATRMARSKDEISHWAEYDYVLVNRDLDLAEEQLKMILSAERLRRDRQPDLMDFVRGLNGEFETR
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23948 Sequence Length: 211 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q11HG8
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGVHYHFKTQRDFEMMRDGGDLLEWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLREKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLRNAHHEIEQWRDYDYVVINDDLDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 24890 Sequence Length: 218 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q3AQL3
MAVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDKATFEKKIEQGGFIEHEFFFGNYYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERSLLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMSFADQFDTIIVNNNLTAAVDDVEAAIVNFIG
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 20968 Sequence Length: 190 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q822M8
MKDKVRVPFSPDHPSCAPKLFTISAPAGAGKTTLVRMLAQEFPDSFQKTLSLTTRAPRPEEVSGIDYWFVSQEEFKQRLDSNNFLEWVLLFGEYYGTSRLEIDEIWKSGKHAVAVIDVEGALSLKSKIPTVTIFISAPSQEELERRLKYRGSEQDSQRQERLQHSLIEQAASNQFEYVIINDDLQKSYEILKSIFIAEEHRNVL
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23398 Sequence Length: 204 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q9Z961
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPREGEVPGKDYHFVSHEEFQRLLDRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQGALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRKERLEHSLIELAAANQFDYVIINDDLNQAYRVLKSIFIAEEHRNIL
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23368 Sequence Length: 205 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q8KFS5
MSAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHFLSREEFEKKIAENGFIEHEFFFGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFGDQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEMELSHAGEFDFVVVNDDLGRTVDAVATRIAEFLPQP
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 21773 Sequence Length: 195 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q9HTM2
MSGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23102 Sequence Length: 203 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q4K3R4
MTHSTGTLYIISAPSGAGKSSLVKALTDAKPEIRVSVSHTTRAMRPGEVDGVNYHFVSRETFVKMGEHGDFLERAEVFGNLYGTSQSHLQQTLDAGHDLILEIDWQGAEQVRKLMPQARSIFILPPSLQALHQRLTNRGQDSDEVIDGRMREAVSEMSHYVDYDYLIINDDFAHALGDLKAIFRANQLQQKRQQQRFGKLLAELLG
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23121 Sequence Length: 206 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q88C87
MNHSSGTLYIVSAPSGAGKTSLVTALTKDDQQIRVSVSHTTRAMRPGEQHGVNYHFVVHEEFKALIAQGDFLEHAEVFGNFYGTSRSALQQTLDQGYDLILEIDWQGAQQVRKLMPQALSVFILPPSQEALRHRLDGRGQDSEEIIAGRMKEAVSEMVHYDEYDYVIINDDFDTALADLKAVFRSNRLLLKKQQQRHAALLKQMIG
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23184 Sequence Length: 206 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q4FQY7
MTGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTRDPRPGEIDGHHYHFTDVDNFVTAISESQFLEHAEVFGNYYGTSEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFILPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYINFDYVIINDNFEVALTELKAIIVADRQTLKRQQQRYQRTITNLLSNIVDK
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23293 Sequence Length: 208 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q984S9
MVPRDLGSRIRRRGLMLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRDSDALLEWAEVHGNCYATPREPAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPPSMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFVIVNDDLDRAFAEVRGIVVAERLRRDRRPGLFDFVSGLLDEKTV
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 25105 Sequence Length: 218 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q7UP92
MNDPSCSSADETAHPGRLVIISGPSGAGKSTVVKQLMKRCDVPLQLSVSATTREPRPGEIHGQDYFFLSHEEFERRRKLNDFVECKQVFSMGQWYGTLKDQVATGLNAGKWVILEIDVQGAMAVLDDPHYRPVTIFVHPGSMEELERRLRNRGTESESSLTARLETAAAEMQCLSRYQYEIINESVDNAVTEICQILLDQRKTTPCSKN
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 23450 Sequence Length: 209 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q2IX83
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVDGRDYYFVDRPKFDAMVEAGEFLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQLRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGRMKKAGDEMSHFDAYDYIVVNDNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK
Function: Essential for recycling GMP and indirectly, cGMP. Catalytic Activity: ATP + GMP = ADP + GDP Sequence Mass (Da): 24616 Sequence Length: 220 Subcellular Location: Cytoplasm EC: 2.7.4.8
Q6A8B2
MDNSVRVRVPATSANLGPGYDCIGLALDLWDEVSVGVLDRPGVMIDVTGEGADTVPHDESHLVMATLRQGLVELGYPHPDAGLHLTAINSIPQSRGLGSSAAAVVSGLALAWGLARPGFPLDRSALLTMAAAIEGHPDNAAPAILGGAQLAWLDGEAVNHIGLTVNPSIVFRVYVPDRLVPTALARQVLPEQVDRVDAVHQVLAASLLVTALTTSPEHLLAATQDWIHQPYRRALMPESAALTDRLRGRGVATVISGAGPTVLALGSRDQLEKVSDVDTAGFVAHDLVLGEGVHFF
Function: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Catalytic Activity: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine Sequence Mass (Da): 31006 Sequence Length: 296 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5....
Q9RRU5
MSSPARPFTVRAPASSANLGPGFDSLGLSVPLYTTLRVTPQDKAEVVPLGTELADTPADESNYVYRAMTLAAKRAGRTLPPARVEIETEVPLARGLGSSAAALVAGVVAGNELLGRPLDDETVLDVTAREEGHPDNVAPALFGGIVVATLDKLGTHYVRLDPPAHLGVTVLVPDFELSTSKARAVLPREYSRADTVHALSHAALLAAALAQGRLDLLRHAMQDYVHQVWRAPLVPGLSDILEHAHEYGALGAALSGAGPTVLCFHDQRGSTATLHHYLHDVMTKNGLSGRVMDFPIDAAGTVVEHAK
Function: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Catalytic Activity: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine Sequence Mass (Da): 32390 Sequence Length: 307 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5....
Q24XU1
MVRVRIPATSANLGPGFDCLGMALSLYNVVQIEAADSFQIALKGDYTAGIPGDETNLVWQSMCNLWEAIGFEIPTVSLELENNIPPTRGMGSSSAAIVGGLVAANEYAGGVLSKQQILQIANRIEGHPDNVAPALLGGVTLAVTAEASVIARTVHSQPQFMALAIVPDFYLSTEKSRNVLPASISRADAVYNLSRTALLVEALIHENHELLKEGMQDRLHQNQRAGLVPGLGETLQVALDSGAYGSALSGSGPTILALVSSHRAEQVSQAMVDSLAAHGLTAKAYLLSVDSEGAAVI
Function: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Catalytic Activity: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine Sequence Mass (Da): 31093 Sequence Length: 297 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5....
Q21017
MAAPRRRMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIID...
Function: Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and ser...
P22209
MHRRQFFQEYRSPQQQQGHPPRSEYQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAII...
Function: This protein is probably a serine/threonine protein kinase. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 51203 Sequence Length: 435 EC: 2.7.11.1
Q01919
MASVPKRHTYGGNVVTDRDRHSLQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIKRHVWLKPHEAFL...
Function: This protein is probably a serine/threonine protein kinase. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 90088 Sequence Length: 800 EC: 2.7.11.1
P25341
MTQQEYRSPSQRLSKGRSMSLPKIFARNLRSLQNNAPPGKNINVNCLNVNSCSLSASPSSQINMACNGNKQDLPIPFPLHVECNDSWSSSKLNKFKSMFNHNRSKSSGTTDASTSEKGTHKREPRSTIHTELLQSSIIGEPNVHSTTSSTLIPNEAICSTPNEISGSSSPDAELFTFDMPTDPSSFHTPSSPSYIAKDSRNLSNGSLNDINENEELQNFHRKISENGSASPLANLSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFNTAKDGLMREDYIALKQPPSLGDIVEPRRSRRLRTKSFGNKFQDITVE...
Function: Flippase activator that phosphorylates DFN1 and DFN2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 81462 Sequence Length: 72...
P16497
MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCD...
Function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 69171 Sequence Length: 606 EC: 2.7.13.3
Q84VQ1
MGNANGKDEDAAAGSGGADVTSSSARSNGGDPSARSRHRRPSSDSMSSSPPGSPARSPSPFLFAPQVPVAPLQRANAPPPNNIQWNQSQRVFDNPPEQGIPTIITWNQGGNDVAVEGSWDNWRSRKKLQKSGKDHSILFVLPSGIYHYKVIVDGESKYIPDLPFVADEVGNVCNILDVHNFVPENPESIVEFEAPPSPDHSYGQTLPAAEDYAKEPLAVPPQLHLTLLGTTEETAIATKPQHVVLNHVFIEQGWTPQSIVALGLTHRFESKYITVVLYKPLTR
Function: Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphoryla...
Q9SCY5
MGNVNAREEANSNNASAVEDEDAEICSREAMSAASDGNHVAPPELMGQSPPHSPRATQSPLMFAPQVPVLPLQRPDEIHIPNPSWMQSPSSLYEEASNEQGIPTMITWCHGGKEIAVEGSWDNWKTRSRLQRSGKDFTIMKVLPSGVYEYRFIVDGQWRHAPELPLARDDAGNTFNILDLQDYVPEDIQSISGFEPPQSPENSYSNLLLGAEDYSKEPPVVPPHLQMTLLNLPAANPDIPSPLPRPQHVILNHLYMQKGKSGPSVVALGSTHRFLAKYVTVVLYKSLQR
Function: Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphoryla...
Q08430
MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLFACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPSAMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNILNFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAASVAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQLYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGD...
Function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 47812 Sequence Length: 428 Subcellular Location: ...
O34206
MSMPLPMKLRTRLFLSISALITVSLFGLLLGLFSVMQLGRAQEQRMSHHYATIEVSQQLRQLLGDQLVILLRETPDGQALERSQNDFRRVLEQGRANTVDSAEQAALDGVRDAYLQLQAHTPALLEAPMVDNDGFSEAFNGLRLRLQDLQQLALAGISDAETSARHRAYLVAGLLGLVGVAILLIGFVTAHSIARRFGAPIETLARAADRIGEGDFDVTLPMTNVAEVGQLTRRFGLMAEALRQYRKTSVEEVLSGERRLQAVLDSIDDGLVIFDNQGRIEHANPVAIRQLFVSNDPHGKRIDEILSDVDVQEAVEKALL...
Function: Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. KinB functions as a membrane-associated protein kinase that phosphorylates AlgB, probably in response to environmental signals. PTM: Autophosphorylated. Location Topology: Multi-pass membrane protein...
P39764
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGTIFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMING...
Function: Phosphorylates the sporulation-regulatory protein Spo0A a transcription factor that also controls biofilm formation (Probable). Requires FloT and FloA for localization to DRMs and for activity . Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass ...
O31671
MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIAAEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPRFSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFTICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAEDQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKK...
Function: Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Loca...
O31661
METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAIFICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLWKEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNRKGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFREIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCD...
Function: Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 85513 Sequence Length: 738 EC: 2.7.13.3
Q8LBB2
MATVPEIKIMRSESLGHRSDVSSPEAKLGMRVEDLWDEQKPQLSPNEKLNACFESIPVSAFPLSSDSQDIEIRSDTSLAEAVQTLSKFKVLSAPVVDVDAPEDASWIDRYIGIVEFPGIVVWLLHQLEPPSPRSPAVAASNGFSHDFTTDVLDNGDSAVTSGNFFEVLTSSELYKNTKVRDISGTFRWAPFLALQKENSFLTMLLLLSKYKMKSIPVVDLGVAKIENIITQSGVIHMLAECAGLLWFEDWGIKTLSEVGLPIMSKDHIIKIYEDEPVLQAFKLMRRKRIGGIPVIERNSEKPVGNISLRDVQFLLTAPEI...
Function: Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphoryla...
P34540
MEPRTDGAECGVQVFCRIRPLNKTEEKNADRFLPKFPSEDSISLGGKVYVFDKVFKPNTTQEQVYKGAAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDNGLSGIIPRIVADIFNHIYSMDENLQFHIKVSYYEIYNEKIRDLLDPEKVNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVAVTNMNEHSSRSHSVFLITVKQEHQTTKKQLTGKLYLVDLAGSEKVSKTGAQGTVLEEAKNINKSLTALGIVISALAEGTKSHVPYRDSKLTRILQESLGGNSRTTVIICASPSHFNEAETKSTL...
Function: Microtubule-dependent motor protein required for organelle transport . Plays a role in endosome transport . Required for the transport of mitochondria along the axon of motor neurons . Involved in the nuclear migration of hyp7 hypodermal precursor cells . Required for the formation of dendritic branches of PV...
A7NI79
MTRLSSGGRIEVICGCMFSGKTEELIRRLNHVRLARQRLIAFTPRRDTRYRLGSLVSHNGLSVEARVIDSIRDTPAHLNTDIHVVAVDELHLLDDPPDAAREVCQDLADRGLRVIVAGLDQDFRAQPFPAMAQLMAVAEQVDKLYAICVRCGAYATRSQRLIDGKPAPADAPTIVVGGQELYEARCRACYEPAR
Catalytic Activity: ATP + thymidine = ADP + dTMP + H(+) Sequence Mass (Da): 21494 Sequence Length: 194 Subcellular Location: Cytoplasm EC: 2.7.1.21
Q5LUY8
MAKLYFNYSTMNAGKSTVLLQASHNYRERGMQTYLMTAAIDGRAGTGRIASRIGIGAEADIFTPRDDVFAMIRDRLGAGPVACVFVDEAQFLSPEQVWQLARVVDDLDVPVLAYGLRVDFQGKLFPGSATLLALADEMREVRTICKCGRKATMVIRQDASGRAITEGAQVQIGGNETYVSLCRKHWREATGDPGAKGH
Catalytic Activity: ATP + thymidine = ADP + dTMP + H(+) Sequence Mass (Da): 21618 Sequence Length: 198 Subcellular Location: Cytoplasm EC: 2.7.1.21
Q2RZH4
MDRDRTTGWMEVICGSMFSGKTEELIRRLRRARIARQHTRVFKPALDERYSEDEVVSHNENSVTTTPVEAPPQIQELVQEADVVGIDEAQFFDDDLVPTCQALAEDGHRVIVVGLDTDYRAEPFDPMPQLMAVAEHVTKLHAVCVVCGAPANHSQRIVPGEDRVLVGATEAYEPRCRACFEPEPVTVTRPRPHTEALRAVATDDADASTNEADPEAADAASADGTAA
Catalytic Activity: ATP + thymidine = ADP + dTMP + H(+) Sequence Mass (Da): 24876 Sequence Length: 227 Subcellular Location: Cytoplasm EC: 2.7.1.21
Q07866
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC...
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport . The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). PTM: Phosphorylation at Ser-460 by ERK inhibits interaction with CLSTN1 an...
Q9H0B6
MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFH...
Function: Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence dire...
O88448
MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLASHEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEMLPQEEKGDVPKDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHP...
Function: Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosome...
Q6P597
MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEI...
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath form...
Q9UH77
MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECY...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron . The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tub...
E0CZ16
MEGESVKPSPQPTAQAEDEEKNRRTVTVNAAHMGKAFKVMNELRSKRLLCDVMIVAEDVEVEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLDHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECY...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron . The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tub...
Q5REP9
MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYVYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKGTRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECY...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubu...
Q5ZI33
MAAPGSEKSSKKKTEKKLAAREEAKLLAGFMGVMNSMRKQRTLCDVILMVQERRIPAHRVVLASASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVEGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIR...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity). Sequence Mass (Da): 66196 Sequence Length: 586 Pathway: P...
Q8IXQ5
MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIR...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Sequence Mass (Da): 65992 Sequence Length: 586 Pathway: Protein modificat...
G5ED84
MPVYAKAIFGSFPSVQQVRVENGERCLIEAMDELNKNEKGLYRPVRLENGDQISTTDDVLNGKLARVSYTPFEEFELVSNSKGSCMEYENQEQSSKIMEQMRILRQTEELCDVELLVAGSVIRAHRYILAAASPYFKAMFTNGMVEMKKLTIELQDIPEESVRIIVDYIYTDKIAITMNNVHQLIFTATVLQMDVIVVACQQFLATMITSHNCMSLYHFSDIYNCTNLISSIEDFASSQFRCIRKSPEFNSISFHHLKSLLNRSDLNVSEEQDVFETIVQWVSSNPRDRQHHFVQLFKTLRLHLVGWNFLCEAVNSNSYV...
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ub...
O43240
MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN
Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Sequence Mass (Da): 30170 Sequence Length: 276 Subcellular Location: Secreted EC: 3.4.21.-
Q07970
MASRNQNRPPRSPNAKKEGLGGISFDKRRKVETQGGTGRRQAFSAVNKQDVTMNSDVGSIEECGKVDFTKDEILALLSERAKAGKFDTKAKIEQMTDIIKRLKVCVKWFQQADETHVQEKENLKVSLESSEQKYNHKELEARTKEEELQATISKLEENVVSLHEKLAKEESSTQDAIECHRREKEARVAAEKVQASLGEELDKVKEEKMAAKQKVTSLEDMYKRLQEYNTSLQQYNSKLQTDLETVRAALTRAEKEKSSILENLSTLRGHSKSLQDQLSSSRVLQDDAIKQKDSLLSEVTNLRNELQQVRDDRDRQVVQS...
Function: Kinesin that supports microtubule movement in an ATP-dependent manner and has a minus-end directed polarity. Plays a crucial role in spindle morphogenesis in male meiosis. In mitosis, is required for normal microtubule accumulation at the spindle poles during prophase and may play a role in spindle assembly d...
F4JGP4
MPLRNQNRAPLPSPNVKKEALSSIPFDKRRKETQGTGRRQVLSTVNRQDANSDVGSTEECGKVEFTKDEVLALLNERAKAGKFDTKGKIEQMTDIIKKLKVCVRWYQQVDETHVQDKENLSSSLQSAEKRYSDKELDAKTKEEELRATITEMKENIESLQEKLSKEKLSKLDAIENHRREKDCRVVAEKLQVSLREELDKVKEEKMAAKQKVTSLEDMYKRLQEYNTSLQQYNTKLQTDLEVAREAHTRAEKEKSSILENLTTLRGHSKSLQDQLASSRVSQDEAVKQKDSLLMEVNNLQSELQQVRDDRDRHVVQSQKL...
Function: Kinesin that supports microtubule movement in an ATP-dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein. During mitosis, is involved in early spindle assembly. Participates in the capture of antiparallel interpolar microtubules and helps in generating forc...
P34885
MLFTGTVRVRVLEARQLRPTEWSRRFRQDEAATAAIDSYVNVDWDEYHIGKTQVRPKTNEPRWNEEFTASGVHQGKAIGFSVFHSCVMPPDDFVANTRIAFDQLKIGSANDIWVDLEPHGQLHVVVEMHGTNVEDVHSHNKTRVFKERTNAFNDRQRRGAMRRKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMS...
Function: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein...
Q16974
MEKRVARRGALRQKNVHEVKNHKFLARFFKQPTFCSHCKDFIWGFGKQGFQCQVCSLVVHKRCHEFVCFICPGADKGPDSDATNLHKFKLHSYGSPTFCDHCGSLLYGLLHQGLKCDSCDMNVHKRCEKNVPLLCGTDHTERRGRILIKGAVKGSKVLVEILEAKNLCPMDPNGLADPYVKVKLIPYDAHKLKLKTKTIKASLNPVWNESFTVDIGPEDNSKRLSLEVWDWDRTSRNDFMGSLSFGISELIKSPVEGWFKLLNQEEGEFYGVPVTDDITESIQEIKSKMHRSSISSEKRYPEPDKVQNMSKQDIVRASDF...
Cofactor: Binds 3 Ca(2+) ions per C2 domain. Function: This is calcium-dependent, phospholipid-dependent, serine- and threonine-specific enzyme. Activation of PKC by serotonin results in presynaptic facilitation of depressed sensory-to-motor neuron synapses, which is thought to underlie behavioral dishabituation. Catal...
P34722
MAQAENACRLKLLRADVPVDLLPAGCSATDLQPAVNVKEKIEVNGESRLVQKKKTLYPEWEKCWDTAVAEGRILQIVLMFNQTPVVEATMRLEDIISKCKSDAITHIWINTKPNGRILAQTRHLKNAPDDDHPVEDIMTSRSNSGPGIQRRRGAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCGVNQKQLSEMYHEIKRGTHATASCPPNIANLHL...
Function: Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway . Plays a role in resistance to fungal infection a...
Q6ZFT5
MEVVVARQPKAKKQINLFYCSECEELALKVAASSDTIHLQSINWRSFDDGFPNLFINNAHDIRGQHVAFLASFSSPSVIFEQISVIFALPKLFIASFTLVLPFFPTGSFERVEEEGDVATAFTLARILSMIPKSRGGPTSVVIYDIHALQERFYFGDDVLPCFETGIPLLLQRLRQLPDADNITIAFPDDGAWKRFHKLLLNFPMVVCAKVREGDKRIVRIKEGNPEGRHVVIVDDLVQSGGTLRECQKVLAAHGAAKVSAYVTHAVFPKQSYERFTHTNSAGSADKFAYFWITDSCPQTVKAINQQPPFEVLSLAGSIA...
Cofactor: Binds 1 Mg(2+) ion per subunit. Catalytic Activity: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) Sequence Mass (Da): 36149 Sequence Length: 325 EC: 2.7.6.1
Q9XGA1
MEKPNTKQVLLFYCVEAEELARKVAAQSPLITLQSINWRSFDDGFPNLFINNAQDIRGQHVAFLAAFSSPAVIFEQLSVIYALPRLFVASFTLVLPFFPTGSFERMEEEGDVATAFTMARILSNIPVSRGGPTSVVIYDIHALQERFYFSDNVLPLFETGIPLLKQRLDQLPDADKIVVAFPDDGAWKRFHKQLDHFPMVVCAKVREGDKRIVRLKEGNPAGCHVVIVDDLVQSGGTLIECQKVLAAHGATKVSAYVTHAVFPKNSFERFTHKDDGSDKAFTYFWITDSCPRTVKSIANKAPFEVLSLAGSIADALQI
Catalytic Activity: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) Sequence Mass (Da): 35385 Sequence Length: 318 Subcellular Location: Cytoplasm EC: 2.7.6.1
Q9YAW0
MEGPEQWVIVGGWGSASAEFSEGLSRNMGLKLVKPVFKLFPDEEEYVRIEGDISGFTGAIVVQSFERPASRSLVYSLLIADALKEAGVGRIVLMAPYMGYTRQDRVFLPGEPVSVRAVMRALASSGYNALASIEVHKEYVLDYFDGSTLNIFPFTYMLKETGISCGDNTIIVAPDKGSLPRVERLARETGCRSYGYLVKERDRITGEVRLAKSTVDPRGKNAIVVDDIISTGGTIALASQWLLENGANSVFVLAAHYLGIGNAEEKMMKAGVSRVVTGNTLPRKPSKIVTYVDLTGLAAGQLTKLVSNL
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Catalytic Activity: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-r...
P14193
MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDGEVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEYFEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGKTAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVTNSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS
Cofactor: Binds 2 Mg(2+) ions per subunit. Each Mg(2+) binds only one residue (His-136 and Asp-175, respectively) of this protein, however the magnesium ions also bind substrates and water molecules to complete their coordination spheres . Can also use Mn(2+) and Cd(2+) ions, but the activity is less than that obtained...
Q8G5P2
MVSAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGADVFVLQSHYKPINKAIMEQLIMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRLVFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVLVDYIRDRFQGHLDNVAVVSPDAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAGTIAGACHVLQDAGAKSVTVVATHGVLSGPAVERLKNCGAREVVLTDTVPIPEEKRWDGLTVLSIAPLLASAIRAVFEDG...
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Catalytic Activity: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-r...
Q89DJ1
MSAKNGSIKLVAGNSNPALAQAIAQGLHLPLTKAVVRRFADMEIFVEIQENVRGSDAFIIQSTSFPANDHLMELLIITDALRRSSARRITAVLPYFGYARQDRKSGSRTPISAKLVANLITQAGVDRVMTLDLHAGQIQGFFDIPTDNLYAAPLMVRDIKDKFDLSKTMVISPDVGGVARARGLAKRINTPLAIVDKRRERPGESEVMNVIGDVAGYTCILVDDIVDSGGTLVNAADALIAKGAKDVYAYITHGVLSGGAAARITNSKLKELVITDSILPTDAVSKAPNIRTLPIASLISDAIARTAAEESVSSLFD
Cofactor: Binds 2 Mg(2+) ions per subunit. Function: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Catalytic Activity: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-r...
P11980
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRA...
Function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic proc...
P30613
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGV...
Function: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. Catalytic Activity: ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate Sequence Mass (Da): 61830 Sequence Length: 574 Pathway: Carbohydrate degradation; glycolys...
A0A1X9ISP7
MSLLLSNSALVGPKFRSSRISHASASLDIGLQRATSPQNASVATCFEETKGRIAKLFHKNELSVSTYDTAWVAMVPSPTSSEEPCFPACLNWLLENQCHDGSWARPHHHHMLKKDVLSSTLACILALKKWGVGEEQISRGLHFVELNFASATEKGQITPMGFDIIFPAMLDNARGLSLNLQLEPTTLNDLIYKRDLELKRCNQSNSAEKEVYWAHIAEGMGKLQDWESVMKYQRKNGSLFNSPSTTAAAFIALRNSDCLNYLYSAMNKFGSAVPAVYPLDIYSQLCLVDNLERLGISRFFSTEIQSVLDDTYRCWLDGDE...
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities . Catalyzes the conversion of ent-copalyl diphosphate (ent-...
Q0JA81
MVPALRRGGGGPRFPQCVAWIQRNQRGDGSWRHAAAAHQQLGSSPEIVTERDLSSTLACVLALARWDAGSEHVRRGLQFIGRNMSVAMDDQTAAPASGSVVSFAAMLRMAMEMGLEVPAVSQADVRDRDAGVICHGGRTEYTAYVSEGLGNIQNWNEVMKFQRKNGSLFNSPYTTAAALVHNYDAKALQYLDMLLDKFGSAVPAAYPANIQSQLYMVDVLEKMGISRHFVGEIKSILDMTYSCWKQRDEEIVLDMQTCGMAFRMLRMNGYDVSSDELSHFSEPSSFHNSLQGYLNDTRSLLELHKASKVSIAEKEVILDN...
Cofactor: Binds 3 Mg(2+) ions per subunit. Sequence Mass (Da): 102596 Sequence Length: 937 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). EC: 4.2.3.-
A0A1X9ISH5
MSTLKLIPFSTSIDKQFSGRTSILGGKCCLQIDGPKTTKKQSKILVEKIRERISNGKVVEISASAYDTAWVAMVPSREMSGRPSFPECLDWIVENQNPDGSWGLNPFLVKDSLSCTLACLLALRKWGLPNHLLHKGIEFIESNISRAATDDENQVAPIGFNIIFPAMISYAKELDLTLTLPPSSLNALLRARDSEMIRREGKWEYVGEGLGDSCNWNQIIQKHQSRNGSLFNSPATTAAAAIHCRDHKCFDYLISVVNKCNGWAPTVYPMDIYARLCMIDTLQRLGIDCHFRVELDAIFDEIYRNWQEREEEIFSDVTCQ...
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities . Catalyzes the conversion of (+)-copalyl diphosphate ((+)-...
Q0JA83
MFQLELVNVVMHQRKAIEDTMRKKKKQQLHKFEMLPSPYDTAWVAMVPLPGSSSQLPCFPQCVEWILQNQQSNGSWDLNQLDSITKDALLSTLACVLALRRGLLFIGRNFSIAMDEQLAAPIGFNITFPGMLSSVIEMGLEVPIGQTDVERVLHLQETELKREYEENYRGRNTYMAYVSEGLGNAQDWNEVMNFQRKNGSLFNSLSITAAVLVHNYDAKAHRYLNLLLNKFGTAVYTKNIHRQLSMLDALENMGISRHFDGEIKSILDMTYSCWLQRDEEVMLDITTCAMAFRILRMNGYDVSSDDLCHIAEVSDFHSSH...
Cofactor: Binds 3 Mg(2+) ions per subunit. Sequence Mass (Da): 84125 Sequence Length: 739 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). EC: 4.2.3.-