ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q7VRD3
MINNRSVIIGIVVGENSGDILGVGLIRSLKKCFKKVQFFGIGGFRMRSENMECWYDISELSIMGITGVIFRLPKLLNMRRELIKRFLKLKLNIFIGIDFPDFNISLEKRLKKYGITTIHYVSPSIWAWRSNRVFALKEATHNVLLLFPFEKSIYARCGIPNQFIGHPLADEIPLYPNKIALRQKFDIPSNRCCLAILPGSRPKEIQILTKIFMHCAKLLQDTIPNLEILIPLHDTDLINQFVTLTSFISVKFRVLHTLTAWEVMAAADAALLTSGTATLECMLAKCPMVVAYRMNPVIFMLIRHLIKVKWISLPNLLAGK...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosam...
Q493B9
MSSIVPSMHNNRTIIIGIVAGEASGDILGAGLIRTLKKYLKKVRFFGIGGPCMQSEDMKSWYNIEELSVMGFAEIVMKLPRLLYIRRNLARRFINLKPDVFIGIDSPDFNISLENRLKKRGIRTIHYVSPSVWAWRKKRIFALKKATDNILVILPFEKKIYDHFNIPCQFIGHSLADQIPLNPNKVSARQKLGIPHDVYCLAVLPGSRIREIKMLAHDFLVCAKLLKNNFPNLEILVPLTNQTSIKKFISVASTSVKYRVLSNQSAWEIMMAADASLVTAGTATLECMLVKCPMVVAYRMHPLTFMLAKHFINIPWISLP...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosam...
Q7WJ81
MSLRIGMVAGEPSGDLLAGRIIAGLQARAPGVHCAGIGGPQMAARGFEAWHPMHALTVFGYIDAFKRIPSLLSTYGDVKRRLLAEPPSVFVGIDAPDFNLRLEHQLRQAGTPTVHFVGPSIWAWRYERINKIRAAVSHMLVLFPFEEALYRKEGIPVTYVGHPLAGVIPMQPDRAAARARLGIDADARVLAILPGSRSSEIRLLAPRFLQAAAELVRRDPRLQCVVPMVNPQRRAEFEAIAAQHPVPGLRCVTAAEGQGETPVAWSVMEASNAVLVASGTATLETALYKRPMVISYVLSPWMRRIMAWKSGQQRPYLPWV...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q89KQ7
MMQGRDPKRKIFLIATEESGDRLGSALMKVLRQRLGDGVQFEGVGGRTMAREGLETLFPIEELSIVGFAAVVQQLPKILRLIRETADAVLEAVPDALVIIDSPDFTHRVARRVRARNPAIPIVDYVSPQLWAWRPGRARTMLGYVDHVLGLLPFEPEEYRKLGGPPCSYVGHPLIEQLGSLRPNAEEQKRRNSELPVLLVLPGSRRSEIRHHIEVFGAALGRLQAEGRAFELMLPTMPHLEATVREGIASWPVKPQIVIGEAEKRAAFRIAHAALAKSGTVTLELALSGIPMVTAYRVGAIEAFILRRAIRVSSVILANL...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q02AZ6
MPKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGLIEVVAHIPRIYGEFRKLLRAAREERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQAWAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIGHPLAGLVHPALSREEFFKKHRLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMGNSPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIPFYSMVNLIAGRAVVPELMQS...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q2LVL8
MNSKLVLIVAGEASGDLHGASLVGAMVKREPGIRFYGIGGVNLKTAGVDLWADAADMAVVGLTEVASKLRGILTVMHRLKKSMQLLKPDLVILIDYPDFNLPLARSAKKNGIPVFYYISPQVWAWRKGRLRTISGLVDRMAVILPFEEPLYRQAGVDVSFVGHPLLDVVQATSSRDETLRMFGLREDVTTVALLPGSRKGEVTRLLPVMLKAARILTENICPVQFLLPMANTLDETWMKDQIAKADPPGVRLIRGATYDAVAAADAAVVVSGTATLETALLGTPLIVIYKVSALSYLIGRMLISVDHIGLVNIVAGKTVA...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q3A550
MHEVKQPRRIMVVTGEASGDLHGAHLIEAAGKVDPGLSFFGVGGACMAKAGCEILIPGEDLAVMGLVEVLGHFPTIWRAFRKLKKILHGPQRPDALVLIDFAEFNLLLAAQAKKAGVPVLYYVSPQVWAWRRGRVRRIASVVDRLAAIFPFEPELYQGLDIDVEYVGHPLLDEFAITCERDAFLRRLGLDPARQVIGLFPGSRKNELKYIAETILQSAVKLREKHPDAQFLLPVASSFRRQDIEALVAPYGLPVTVVDEPIYDVINACDAVISVSGTVTLQVALVGTPMAIVYKMAPLSFAIGKRLIRVPHIGLANIVAG...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q57310
MRIFISTGEVSGDLQGSLLVGALRQQAEEQNLELELVGLGGEKMAAAGLTLLANTAAIGSVGLTESLRFIIPTWQIQQRVKRYLKTNPIDLLVLIDYMGPNLTIANYLRKTYPNLPILYYIAPQAWVWSPTKRETAQIMAVTDRLLAIFPGEAEFFQKQGLDVTWVGHPLLDRITKEAPSRGSAREKLGIDHNETVITLLPASRIQELRYLLPSICGAAQQLQSQLPNVKLLLPVSLKDYQPQIEQTLKEFNLTVQLLEGKETLTAIAAADLAITKSGTVNLEIALLNVPQVILYRVSPLTMAIARRIFKFNLPFVSPTN...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q3SKM8
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLRHLPELLWIRARITRHFLRERPRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRPERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLADVIPLQAPTGAARATLGLGDGPIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLPLTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIGLPNILARDFVVPERVQEAAT...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D...
Q12EK9
MLAQRTLKSLTKAVGVGLHSGQRVELTLRPAPPDTGIVFRRVDLPQPVDIVISAQAVTDTRLASTISAGGAKVHTVEHLMSACAGLGIDNLYIDITAEEVPILDGSASSFVFLLQSAGIELQSAPKRFIRVLKPVEVREGEGATAKWARLSPYEGYKLSFEIDFDHPAVDSTGQRVEFDLSSGSYSRDIARARTFGFTKDVEMMRANGLALGGGLDNAIVMDDYKVLNSEGLRYNDEFVKHKILDAMGDLYLLGKPLLAAYSAFRSGHAMNNKLLRELLAHQDAYEVVTFADEKRAPQGFATLARAW
Function: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Catalytic Activity: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate S...
P21645
MPSIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGANAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTIYHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGRVIIGDRVEIGACTTIDRGALDDTIIGNGVIIDNQCQIAHNVVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV...
Function: Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers (3R)-3-hydroxytetradecanoyl-ACP over...
B2KAU6
MQISLEELVKITGGELRGNKDFQITAPCSIDNPKEDAVCYFSDGSKAESISSIKAGCFILPSKIKETFKTDKNVIFADNPEWAFTLFLRHYDSSKPKFDRGVHPTAVIGKNVVLGNNITVGAYSVIEDDVTLGDNTVIYPHVYIGRRTFVGKDCILYPNVVVREECIIKDRVIIEAGATIGTDGFGFVLVNYKHEKIPQVGNVIIESDSEIGANTTIDRAKIDSTVIGVNVKVDNLTQLAHNVKVGQGSIIISQVGVAGSTEIGRGVVLAGQVGVAGHIKIGDGVQVGAQSGIMQDIPAGKKMFGTPVRDYMETLKLYAA...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q8R6D9
MEYRVTDIITLLNAEYKGEVVEKVSKLSPFFHSDEKSLTFAADEKFLKNLSQTKAKVIIVPDIDLPLIEGKGYIVVKDSPRVIMPKLLHFFSRNLKKIEKMREDSAKIGENVDIAPNVYIGHDVVIGNNVKIFPNVTIGEGSIIGDGTVIYSNVSIREFVEIGKNCVIQPGAVIGSDGFGFVKVNGNNTKIDQIGTVIVEDEVEIGANTTIDRGAIGDTIIKKYTKIDNLVQIAHNDIIGENCLIISQVGIAGSTTIGNNVTLAGQVGVAGHLEIGDNTMIGAQSGVPGNVEANKILSGHPLVDHREDMKIRVAMKKLPE...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q74AT5
MAVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAVILPPGAERHNHNAIMVPNPYLAFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHPGAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTVYQGCRIGNRVTIHGGTIIGSDGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHNCVIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTIMSGIPAFDHREWLRASAVVP...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q0BTL2
MSVQEVVGDPRFFARSGPYDVAAVAEAVGASIPADCTLSLTGVAPLQIAGPSEVSFLDNRRYADALEQTRAGAVIIKADMVDRVPAGVIALVVPEPYLAWARVAALFYPLPPVQPGIHPSAVVDETACIDPSAQIGPLAVIEAGVEIGPDCRIAAHAVIGAGVKMGRSCRIGSHASLSHAILGDRVYVYPGVRIGQDGFGFAPSSEGFVTVPQLGRVVLENDVEVGANSTIDRGSMHDTVIGAGSRLDNLVMIAHNVRMGRACVIVSQVGISGSTTLGDHVVLAGQAGLIGHLKIGSGARIGAQAGVMADVPAGAEIVGS...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q7VM24
MAVFRLSELAEQIGATLKGNADLAITSIAALNNAEPTHITFISNAKYRSQLSQSKAGAIIVTAEDVEFCQATQNLLIVKDPYLAYALLAQYMDDLPKSANEISESAVISATAKLGKNVSIGANVVIESGVELADDITIGAGCFIGKNTKIGARSHLWANISVYHNVEIGSDCLIQSSAVIGSDGFGYANDKGRWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTIIEDNVIIDNLCQIAHNVHIGFGTAIAGGVILAGSLKIGRFCQIGGASVINGHMEICDGAIITGMSMIMKPITEKGVYSSGIPAQTNKEWRKTAA...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q2SBQ8
MGKTDLSYTLADIAFRIGAELRGDGSVEVKGLATLQKAQAGQISFLANKNYLKHLKDTCASAVIIPSSFADQCSTNVLVMENSYFGYALCSQLFSPQWWSMSGISPSAAISESAKLGAGVTIGANVVIEEDAEIGEGAVIGPGCYIGAGSIIGAKTQLRPNVTVYHGVNIGARALIHSGAVIGSDGFGFAPNKGDWAKIAQLGGVVIGDDVEIGANTTIDRGALDDTVIETGAKLDNQIQIAHNVKVGAYTVIAACVGVSGSSSIGKHCMIGGGVGIAGHLEITDQVQITGMTLVTHNIKEPGVYSSGTAVEPNASWRKN...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
A1WT71
MTSAMTVQELAARLGARLAGDGERPVCRAATLLGAGGDAVSFCTSKRHLPELRRSGAAAVLVRAEHEGDCPGTALVVEDPYLAFIEVVELLHPEPSAPPGIHPGAVVASDVVLGDGVSVGANAVIEAGVELGAGSTVAPGAFIGPGARLGTGSWLGPNAVLAGGCRTGERVRIHAGAVIGADGFGYAPLPDGQGWRKVPQIGGVDIGDDVEIGANATVDRGALEDTVIEAGVKLDDHVHIAHNCRVGARTVIAGGTLVAGSTTIGRDCLIGGLVAITDHIRIADGVSLMGMTGVTGSIRESGAYASPLPAQPVRQWRRNT...
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydrox...
Q1QVV3
MTTLLISDLHLHTGQPDITRGFLDYLERDARHADTLYLLGDIFEAWIGDDYLGDLERQVIEALRRLSDAGTQLYFMHGNRDFLVGEDFAAAAGATLLDDPCLATLGRQTVLLMHGDSLCTGDEEYMKFRAMARDPEWQAQILALPIEQRLELAKSLRMQSSDANTQKADAIMDVTPAEVEAIMREHGVSTLIHGHTHRPAVHEFTLDGQPAQRIVLGDWRPGRGWEVRVEDDAPPRLREFAFQARA
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center. Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated gl...
Q7NT75
MAIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPLAAMRDFAAQTPLYVMRGNRDFLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTDDAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSEMNKQQTGLTDISDVTENAVRELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center. Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated gl...
A9KBJ4
MRHTLFISDLHLEEETPSITAHFLYFLKHQAPKADAIYILGDFFEAWIGDDNQTPFNRKIIESLQTLARTKPTYFMRGNRDFLIGQRFAAMTGVSLLEDPSVIQLYNKPVLLMHGDSLCTLDHKHQAYRRKIMKPWVQKLMLSLPLSLRRKLAKKFREQSRRHNRTLSYGIKDVTPEEVNRVMKEQNVELLIHGHTHRPAIHDLTINGNPTKRIVLGAWHHGGSVLRYAQDGSFELQAFKIDL
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center. Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated gl...
Q2T0K1
MSARPGLLARAEARLTREWQRRGALAWALTPFACAFGAIAALRRAAYARGWKARVDCGVPVVVVGNVTVGGTGKTPTVIALVDALRAAGFTPGVVSRGYGAKIVAPTAVTPASAPQQAGDEPLLIARRTLAPVWVCPDRVAAVRALKAAHPEVDVVVSDDGLQHYRLARAVEIVVFDHRLGGNGFLLPAGPLREPLSRRRDATLVNDPYSRALPPWPDTFALSLAPGDAWHLARPSRRKPLAQFAGERVLAAAGIGAPERFFATLRAAGVTPATRALPDHYAFATNPFVDDHFDAILITEKDAVKLGTSWRDARIWVVPV...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 36555 Sequence Length: 342 P...
A8Z6M1
MFKKFNILLHSWANDYFFRPNFFQILLAFLLLPLSLIYTLVVVCKKFSAQKKDFGIKIISVGNLTLGGSGKTPLCVAIAKNYGGAFIILRGYKRKSKGMQVVARNGEILLDVAASGDEAMIYATSIKNANVIVSEDRKIAINYAKKHGAKYILLDDGFSKFDIAKFDILVRPNPEPKLRLCLPSGAYRYPFSFYKFGNFIACEGQTHFRKSEILNKTEKMVLVTAIANPARLEAFFSECVGQVFFPDHYDFSKEELSEILQSYGATSLLMTQKDYVKVKDFGLRVSLITLEVTLSEEFKKVLAKQI
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 34519 Sequence Length: 306 P...
Q4FS43
MNIETTITRAWQRQAAWLWLLLPVSWLYSLLMILRRQAYKAGIFSSYRAPIPVMVIGNITVGGSGKTPLIIALVRHLQQQGIKVGVISRGYGGDSSQMPALVNTESVPNIVGDEPCLIVNMTGVAMAVCPNRQQAMTTLLASYPDLQLIIADDGLQHYALQRDIEWIVVDAARGFGNKQLLPTGFLREPMSRLKGANVVYHQKADSLSSTDDKYDDTCPPTKRLRMHLQPDNLERLWSFDTQSDGLATVKAMAPEKGSRVHAVSGIGYPQRFFDTLDTLGFQVSPHPYPDHHDFSLTELLRYTEHPIIVTSKDAVKIRAL...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 43039 Sequence Length: 385 P...
A1STC8
MPFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKTPFVIWLCEMLITVGYKPAVISRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVVVDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVIVDGKRRFGNQHLMPIGPLRENLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFFDTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVSAEFSAGFEQQLLNRIKEIKC
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 36309 Sequence Length: 320 P...
P58185
MASEAPPFWWEEPDWKVLALSPLSAVYALVAGRVMRRARREKIEAPVLCVGNFTVGGTGKTPVAIALAQQAKRMQLKPGFLSRGHGGSFAEPHVVDAHHDAAKHVGDEPLLLAEHAPVAVTPNRAAGARLLMAKHGCDFLIMDDGFQSARIHIDYALIVVDARYGIGNGRVIPGGPLRAKIVDQLVFTSGLLKMGEGTAADAVVRQAARAGRPIFEARAEPISKAGLAGKRFLAFAGIGHPDKFFDTVREAGGEVVLSKPFPDHHFYAEDELAELAAVARAEGLGLITTAKDAARLRHGASQDFLNRLEVLEIDTVFELD...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 36941 Sequence Length: 341 P...
Q7UNW7
MSWDYRPLLSGQSRDPFSSMARGALWCASGFYNVAARHRRRQYDSGNREICNAGVPVISVGNLTTGGTGKTPVVADLCRRLRAMDFRVTIISRGYGASDGRMNDEAMELQERLPDVPHVQHPDRVEAARIAVEELAAEVLVMDDGFQHRRLQRDLDIVVIDATCPFGYGHVLPRGTLREPLDSVTRADWVLITRVDQVDPEEVLAIRSTIAQHAPDCPVLETEHRPSTIQSSVGDWEAIEVLIDQPVALVSAIGNPDAFEQTVLDCGAIVVDHLRLPDHDSYERATREKLRSWVTKLKGGPQPPQRLLCTHKDAVKLATD...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 40432 Sequence Length: 365 P...
B6IXD8
MKAPAFWYAPPGTARPLLSALLTPAALAWTAATRRRLSGTRPWHAPVPVICVGNLVAGGAGKTPVVLDLLSRLRRGGLDAHALSRGHGGRLPGPLRVDPARHTAAEVGDEPLLLAAAAPAWIARDRAAGARAAADAGAGVLVLDDGFQNPGIAKDLSLLVVDGDAGFGNGRVIPAGPLREPVADGLARAQAVLLLGEDRRGTADLCRGRLPVLRGRLVPDPQAAADLEGRRVLAFAGIGRPEKLFRTLEALGADVVARLPFPDHHPFTAAELRALLDRAAALDALPVTTQKDLVRLPAELRGQVRALPVSIAWEEPDTLD...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 35254 Sequence Length: 337 P...
Q2RWV9
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPVALAVMDALRRRGVVGHFLSRGYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRNRASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGYGFGNGRYIPAGPLRESIEAGLARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPEKFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRPQVDVVGVRVVFDEPLAFEAL...
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 34631 Sequence Length: 331 P...
Q5VT99
MRPRAPACAAAALGLCSLLLLLAPGHACPAGCACTDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD
Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. Location Topology: Single-pass t...
Q8CN54
MVILEQTHLVKNKAVDNKKSMKYSIFQQALTIAVILLISKIIESFMPIPMPASVIGLVLLFIALCTGIVKLGQVETVGTALTNNIGFLFVPAGISVINSLPILKQSPILIILLIIISTLLLLICTGFSSQLLVTKSLFPSKEKNEETSHIGG
Function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in ...
P65264
MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLVLAVAVSAYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKTQEEKY
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
Q1QIP9
MTPLRSGIVAAVAALIADQASKLWLLFVFDIGHRGAVRVTPFFDLVLAWNTGISYGWFQTDSPVGATILLAIKAGAVVLLAIWMARSQTRLATIGLGLIIGGAIGNAIDRFAYGAVVDFVLFHVPLAGKTYSWYVFNLADVAIVAGVIALLYDSFLRTPAAKAP
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
B3CS08
MLLEQVIYIMCNLEVSKNSSRNKLWSLIFGIQLLIIDQLVKSFFINFLKKTPEIAISIFKYFKISYVWNYGISFGIFNYYYDISNNFFLIVNTIIVLCICYLITKAKKLLQFNAYMLIIIGGTSNIIDRMLYGAVFDFIDIYLIIFNLADLYIFVGTILLVIYYSYYE
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
Q7U7A6
MTGSILRRAPLLGVAGLVVLVDQATKLLAASQLADGRIVQLLPGLINGQLVHNTGAAFSLFRGSVQWLGLLSLAVTTGLLIWVVRHRTPPFWQGMAVAFLLGGTLGNGIDRWRLGHVIDFLALVPINFPIFNPADIAINLAVLCFLVDLWSSRTSSRHG
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
B2JDY8
MSRTLSKPAGGSLAPWLGVAVIVILFDQLTKIAVAKVFAYGSSHAIAPFFNLVLVYNRGAAFSFLAMAGGWQRWAFTALGVAAAVLICYLLKRHGTQKMFCTALALIMGGAIGNVIDRLLYGHVIDFLDFHVGAWHWPAFNLADSAITIGAALLVFDELRRVRGAR
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
A5D178
MFLFIIIAVVLLVDQATKAAVQMLMCQGESIPVVPPAFYLTYIMNPGAAFGLLPHKKMLFVTVTVIIIAGVLVGYFKIRPRKPVLDYGLGLVAGGALGNLADRLRYGLVVDFLDFRIWPVFNLADTAIVTGAFLLAWALLNDSDKSSKKERK
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
Q4FPB0
MNKINLKNFYLNLVIILVVFIFDRTTKLYILKLAEVETSVDIYITPFLNLFLIWNKGIAFGLFSIDGSVIYNSITILIGLIIIAIIFMMLKNDNIQRYFFALIAGGAFGNFYDRIVYTAVPDFIDLHFYGFHWFVFNVADIFITIGVFCLILVELFFNNKKTNEKN
Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or ...
Q1C138
MPHTVATPPPLLQVRGISKQFSGVVVLKSIDFTLQPGQVHALLGGNGAGKSTLMKIIAGILPPDTGVIEMNGQPCFNLTPAKAHQLGIYLVPQEPMLFANLSVQENILFRLPKHQADKKKMAQLLKNLGCHLDLSVSAGSLEVADQQLVEIMRGLIRDSHILILDEPTASLTPAETHRLFSQIRMLLQQGVGVVFISHKLPEIRQLADWVSVMRDGGIALSGATADFSTEDMIQAMTPEAQKGALTDSQKLWLELPGNRRAQSHAQSQQPVIHVHDLSGEGFAHISFHVQAGEILGLAGVVGAGRTELAETLYGLRPAST...
Function: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system. Catalytic Activity: ATP + H2O + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran-[AI-2-binding protein]Side 1 = ADP + phosphate + (2R,4S)-2-methyl-2,3,3,4-tetrahydr...
Q9HCC9
MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPL...
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. PTM: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Sequence Mass (Da): 9...
Q6ZPK7
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKEPQRCTLLVSQFRSCQDNVLNIINQIMEECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGTLRDQALRDLNTYTEKMREALRRFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQALTEEELHTLERSLCVSQDVELPIRADTQAPSALAPTFSASLPPEETL...
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). PTM: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Seque...
Q0P4S0
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKDPQRCTLLVNQFRSCQDNVLNIINQIMEECIAHERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDLTRSLEEVRNLIRDQALRDLNIYTEKMKESLRHFDVLFAEFELSYVSAMVPVKSPKEYYVQQEVIVLFCETVERALKLGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYAEGPLNLERKPEDMSELFRPFHTLLRKIRDLLQTLTEDELHTLERNLCISQDVEFPANADPEVPSAISPVLVTALPTEEPP...
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). PTM: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Seque...
Q8I4E2
MAQVKAEYDFQSQPNTGELSISAGEVLTVIRENIDGGWIEGRNVRGSVGLFPESYVTPYQASRPPPVLPPPLPPTSSGPPAASSRPFDDWGGASEVAAPPSYGAQHHHQPTPSVPEVTRSSYPSQNDDFDDEWTDEDDEQEPTRPNVQSSIGSNSRRDLSRSHSEHGGPDRGSNKVNKNINRFSNFVKSGVEAYVIGESKTTSQISERHEVVMNNGIIQWKPIQQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHP...
Function: Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dy...
Q6CZ26
MKKTSDYAVAVIGLGSMGFGAAASCINAGLTTYGVDINPQALEKLRQAGAAQADTRIDAFADKLDAVVLLVVNATQVNGILFGEPQVAAKLKPGTVVMVSSTISAQDAKNIEQRLAEHQLVMLDAPVSGGAAKAAAGDMTVMASGSDLAFEKLKPVLDAVAGKVYRIGEEIGLGATVKIIHQLLAGVHIAAGAEAMALAARADIPLDIMYDVVTNAAGNSWMFENRMRHVVDGDYTPKSAVDIFVKDLGLVTDTAKSLHFPLPLASTAFNMFTAASNAGFGKEDDSAVIKIFNGITLPEKKEAP
Function: Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+). Catalytic Activity: L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH Sequence Mass (Da): 31629 Sequence Length: 304 EC: 1.1.1.411
Q8L540
MMARFVSVSSCQFHFGFREVSPPSVTSYPRRFEVSDRRFPAIPIKCSSSEPENGEDSAPSLSSSSSSSTSEVSTSNSSTYNWYTGIGGIGMLDTAYLTYLKVTGSDAFCPIGGGTCGDVLNSDYAVVFGVPLPVIGFVMYGVVTALSAELGEGNLPFGISKSNGRFALFGITTAMASASAYFLYILSTKLSGSSCLYCLVSAFLSFSLFFLSVKDVKLQEIQQVVGLQICLAIIVVASLTASYSTAQPIPSRSGDIELPYFRTEISSSSSPYAIALAKHLNSIGAKMYGAFWCSHCLEQKEMFGREAAKELNYVECFPDG...
Function: Thiol-disulfide oxidoreductase catalyzing disulfide bond formation of chloroplast proteins and involved in redox regulation and photosynthetic electron transport. Required for the assembly of photosystem II (PSII) through the formation of disulfide bond in PSBO, a subunit of the PSII oxygen-evolving complex i...
Q6IAA8
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
Function: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the R...
Q6P2W7
MGCCYSGETDTGKGDQGEREHLLPQSQSLPNKAPNESEQNSTNNPSARTDEQAMLSRILAKTAQNIIDVSAVESQGMEQHECMDRARQYSTRLAKLSSNLMDWKKVPPLPSLTSQPHQILASDPVPFADIQQVSKIAAYAFSALSQIRVDAKEDLVVQFGIP
Function: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ra...
Q9Y2Q5
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual ro...
Q9JHS3
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator ...
D4A8G3
MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGECDLGTSGDVLLPGASSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPERSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVAPRELDEQGHPGPSCPEIDWAKVIPSEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDDSAKQGFEAHWYWGQCQDDVTFL
Function: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modul...
Q6TBX7
MESSLFSPSSSSYSSLFTAKPTRLLSPKPKFTFSIRSSIEKPKPKLETNSSKSQSWVSPDWLTTLTRTLSSGKNDESGIPIANAKLDDVADLLGGALFLPLYKWMNEYGPIYRLAAGPRNFVIVSDPAIAKHVLRNYPKYAKGLVAEVSEFLFGSGFAIAEGPLWTARRRAVVPSLHRRYLSVIVERVFCKCAERLVEKLQPYAEDGSAVNMEAKFSQMTLDVIGLSLFNYNFDSLTTDSPVIEAVYTALKEAELRSTDLLPYWKIDALCKIVPRQVKAEKAVTLIRETVEDLIAKCKEIVEREGERINDEEYVNDADPS...
Function: Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls. Specific for epsilon- and beta-ring hydroxylation of alpha-carotene. Has only a low activity toward the beta-rings of beta-carotene. The preferred substrate in planta is not alpha-carotene but the epsilon-ring of zeinoxanthin . Poss...
Q93VK5
MAMAFPLSYTPTITVKPVTYSRRSNFVVFSSSSNGRDPLEENSVPNGVKSLEKLQEEKRRAELSARIASGAFTVRKSSFPSTVKNGLSKIGIPSNVLDFMFDWTGSDQDYPKVPEAKGSIQAVRNEAFFIPLYELFLTYGGIFRLTFGPKSFLIVSDPSIAKHILKDNAKAYSKGILAEILDFVMGKGLIPADGEIWRRRRRAIVPALHQKYVAAMISLFGEASDRLCQKLDAAALKGEEVEMESLFSRLTLDIIGKAVFNYDFDSLTNDTGVIEAVYTVLREAEDRSVSPIPVWDIPIWKDISPRQRKVATSLKLINDT...
Function: Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls. Specific for beta-ring hydroxylation of alpha- and beta-carotene. Has also a low activity toward the epsilon-rings of alpha-carotene. The beta-ring of alpha-carotene is the preferred substrate in planta. Sequence Mass (Da): 66846 Se...
Q97F13
MEKIASFTVNHLTLQPGVYVSRKDKFGDVVITTFDIRMTSPNEEPVMNTAEVHTIEHLGATFLRNHGTYAEKTVYFGPMGCRTGFYLILQGDYTSNDIVPLLREMYKFIADFKGEVPGAAARDCGNYLDMNLPMANYWGKKFSALLDNISEDRLNYPE
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
B2UWX8
MEKVESFELDHRKVKAPYIRKCCLLDGKCGDKVTKFDIRFLQPNKEEFGTAAMHGLEHLLAHELRAKLEGIIDLSPMGCRTGFYLSIWGDREASEIKEALEYSLEKVLEAKEIPAANDIQCGNYRDLSLFGAKEYAKEALERGFSLNIYGE
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
Q181K1
MEKVESFKLDHTKVKAPFVRKCSVLDGVKGDKVTKFDLRFLQPNVESFGTAAMHGLEHLLATYLRDTLDGVIDLSPMGCRTGFYLILWGDVDAKTVKIGLEEALKKVLESDKMPAATAIECGNYRDLSLFGAKEYAKDVLDKGFSLNIYGE
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
Q9XDU6
MVKVESFELDHTKVKAPYVRKAGIKIGPKGDIVSKFDLRFVQPNKELLSDKGMHTLEHFLAGFMREKLDDVIDISPMGCKTGFYLTSFGDIDVKDIIEALEYSLSKVLEQEEIPAANELQCGSAKLHSLELAKSHAKQVLENGISDKFYVE
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
Q6AAL4
MAHKMNVESFNLDHTKVAAPFVRVADVKHLPAGDTLTKYDVRFCQPNKEHLDMPAVHSLEHSFAECVRNHSDAVIDFGPMGCQTGFYLIMIGEPDVSGTCELVETTLRDILKLNTTPAANEVQCGWGANHSIKAAQEAAHTMLNHRDEWEQVMA
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
Q1IW42
MANVESFDLDHTKVQAPYVRLAGVKTTPRGDQISKYDLRLLQPNRGAIEPAALHTLEHLLAGYLRDHLQNVVDVSPMGCRTGLYLAVIGEPDEEGVLQAFEAALRDTATHDRPIPGVSELECGNYRDHDLQAARQYARDALTQGLKVQKTILLQR
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
Q9RRU8
MPDMANVESFDLDHTKVKAPYVRLAGVKTTPKGDQISKYDLRFLQPNQGAIDPAAIHTLEHLLAGYMRDHLEGVVDVSPMGCRTGMYMAVIGEPDEQGVMKAFEAALKDTAGHDQPIPGVSELECGNYRDHDLAAARQHARDVLDQGLKVQETILLER
Cofactor: Binds 1 Fe cation per subunit. Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum se...
A0A3G9JYH7
MRINISLSSLFERLSKLSSRSIAITCGVVLASAIAFPIIRRDYQTFLEVGPSYAPQNFRGYIIVCVLSLFRQEQKGLAIYDRLPEKRRWLADLPFREGTRPSITSHIIQRQRTQLVDQEFATRELIDKVIPRVQARHTDKTFLSTSKFEFHAKAIFLLPSIPINDPLNIPSHDTVRRTKREIAHMHDYHDCTLHLALAAQDGKEVLKKGWGQRHPLAGPGVPGPPTEWTFLYAPRNEEEARVVEMIVEASIGYMTNDPAGKIVENAK
Function: Luciferase; part of the gene cluster that mediates the fungal bioluminescence cycle . Uses the fungal luciferin 3-hydroxyhispidin as a substrate to produce an endoperoxide as a high-energy intermediate with decomposition that yields oxyluciferin (also known as caffeoylpyruvate) and light emission . The fungal...
Q7Z3F1
MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLY...
Function: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway . Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . ...
M0L7V9
MPELPTDRLTAVIPPEETLLGYLLRLSRPRFWLYLGGPVIVGVSYAADGPGELFSPLAIALFLYFTIPGNVFLYGVNDIFDADIDEHNPKKDDGREVSYRGDSAVTAIVVASGALALLFALVLPTLGIVALLAWMALSVEYSAPPLRFKTTPFLDSISNGLYILPGVIGYAAIEGVAPPATAVVGAWLWAMGMHTFSAIPDIEPDREAGIQTTATFLGESNTYYYCVMCWLMAAFVFNFTHWVFGVLLLVYPGLVFGILGVGVDIDEAYWWYPAINTVVGMVFTLIALWVMLYG
Function: Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR) . Acts as a bifunctional elongase/hydratase that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the previous end of the molecule . The enzyme acts at both ends of the...
Q9HPD9
MFRYLFVLSRPRFWLYLAGPVLVGVSYGATTVGELFSAPAVVLFSYFLLPANIYLYGINDVFDRDVDETNPKKDGRESRYRGGAAVAVIVAVCGVFLGFVAAPLPAEAWPYLAAWFVLATEYSAPPLRFKTTPVLDSLSNGLYVLPAAAAYAGVSGTHPPLLAVAGGWLWAMGMHTFSAIPDIEPDRAAGIQTTATALGADRALAYCAGIWLLSAAVFALVDVRFGLLLLAYPVLVFGIRRLQVAVGRAYWWYPAVNTLVGMVFTLGGLWGVVHG
Function: Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR) . Acts as a bifunctional elongase/hydratase that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the previous end of the molecule . The enzyme acts at both ends of the...
Q86SG7
MLSSVVFWGLIALIGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFKSGIEAIATPSDIDNDFVNDIIARAKFYKRQSF
Function: May act as a potent antibacterial protein that may play a role in the innate immunity. Sequence Mass (Da): 23498 Sequence Length: 212 Subcellular Location: Secreted EC: 3.2.1.-
Q90X99
MGYGNIMNVETTGASWQTAQQDKLGYSGVRASHTMANTDSGRMERYRSKINSVGAKYGIDPALIAAIISEESRAGNVLHDGWGDYDSNRGAYNAWGLMQVDVNPNGGGHTARGAWDSEEHLSQGAEILVYFIGRIRNKFPGWNTEQQLKGGIAAYNMGDGNVHSYDNVDGRTTGGDYSNDVVARAQWYKTQKGF
Function: Has lytic activity against M.lysodeikticus, V.alginolyticus from Epinephelus fario, V.vulnificus from culture water, A.hydrophila from soft-shell turtle, A.hydrophila from goldfish and V.parahaemolyticus, P.fluorescens and V.fluvialis from culture water. Catalytic Activity: Hydrolysis of (1->4)-beta-linkages ...
Q90VZ3
MSYGQIRLVETSGASGATSQQDNLGYSGVKASHKMAEIDSGRMSKYKSKINKVGQSYGIEPALIAAIISRESRAGNQLKDGWGDWNPQRQAYNAWGLMQVDVNPNGGGHTAVGGWDSEDHLRQATGILVTFIERIRTKFPGWSKEKQLKGGIAAYNMGDKNVHSYEGVDENTTGRDYSNDVTARAQWYRDNGYSG
Function: Possesses lytic activity against M.lysodeikticus and several fish pathogenic bacteria. Catalytic Activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Sequence Mass (Da): 21...
Q86UE4
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPS...
Function: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also...
Q9Z1W6
MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDPAQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSA...
Function: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also...
P04421
MKALVILGFLFLSVAVQGKVFERCELARTLKKLGLDGYKGVSLANWLCLTKWESSYNTKATNYNPSSESTDYGIFQINSKWWCNDGKTPNAVDGCHVSCRELMENDIAKAVACAKHIVSEQGITAWVAWKSHCRDHDVSSYVEGCTL
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Catalytic Activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidog...
P00698
MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. Catalytic Activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and ...
P00708
KDIPRCELVKILRRHGFEGFVGKTVANWVCLVKHESGYRTTAFNNNGPNSRDYGIFQINSKYWCNDGKTRGSKNACNINCSKLRDDNIADDIQCAKKIAREARGLTPWVAWKKYCQGKDLSSYVRGC
Cofactor: Binds 1 Ca(2+) ion per subunit. Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Catalytic Activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-a...
Q4L8V4
MKTLIVDDEPLARNELHYLLNEISGFNVIDEAENIEETLEKLLSETYDLVFLDINLMDESGIDLAQKIKKMKQPPHIIFATAHDTFAVKAFELDAIDYILKPFELERIEQAVNKVKHQISNSNEIDHITSEPSTLSMQQDDRQENEDQTVLPIEMNERIYVIRKDDITAVSVNNGITTINTTHRTYQTNEPLNYYEKKLSNNTFIKIHRATIINKTHIDSVEHWFNYTYQVTMTSGDKFQVSRSFMKAFKHEIGLA
Function: Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. PTM: Phosphorylated by LytS. Sequence Mass (Da): 29725 Sequence Length: 256 Subcellular Location: Cytoplasm
Q8DVB7
MNILILDDEMLARQELTFLIQQSKELDHPDIFEAEDISSAEKILFRQQIDLIFLDISLSEENGFTLANQLEQLAHPPLVVFATAYDHYAVKAFESNAADYILKPFEQGRVDKALAKVKKIQHLSTIDETATTEKKGMELLTLTLADRSIVLKMPDIVAASIEDGELTVSTKNTSYTIKKTLNWFKTRAKTNYFLQIHRNTVVNLEMIQEIQPWFNHTLLLVMVNGEKFPVGRSYMKELNAHLTL
Function: Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. PTM: Phosphorylated by LytS. Sequence Mass (Da): 27913 Sequence Length: 244 Subcellular Location: Cytoplasm
P94513
MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIGMESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAI...
Function: Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64855 Sequence Length: 593 Subcellular...
Q8EQQ2
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGVVMIGNELIMQAWIINVAENEVLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGGWVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFPPVLHMGLLLIMLPDQQIGVQIVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTMNARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIAYHQSDIQCGVENCKLKTAIM...
Function: Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64669 Sequence Length: 585 Subcellular...
Q2FK10
MLSLTMLLLERVGLIIILAYVLMNIPYFKNLMNRRRTWKARWQLCIIFSLFALMSNLTGIVIDHQHSLSGSVYFRLDDDVSLANTRVLTIGVAGLVGGPFVGLFVGVISGIFRVYMGGADAQVYLISSIFIGIIAGYFGLQAQRRKRYPSIAKSAMIGIVMEMIQMLSILTFSHDKAYAVDLISLIALPMIIVNSVGTAIFMSIIISTLKQEEQMKAVQTHDVLQLMNQTLPYFKEGLNRESAQQIAMIIKNLMKVSAVAITSKNEILSHVGAGSDHHIPTNEILTSLSKDVLKSGKLKEVHTKEEIGCSHPNCPLRAAI...
Function: Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism. Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs). Functions as a sensor protein kinase which ...
Q6WB97
MSRKAPCKYEVRGKCNRGSECKFNHNYWSWPDRYLLIRSNYLLNQLLRNTDRADGLSIISGAGREDRTQDFVLGSTNVVQGYIDDNQSITKAAACYSLHNIIKQLQEVEVRQARDSKLSDSKHVALHNLILSYMEMSKTPASLINNLKRLPREKLKKLAKLIIDLSAGADNDSSYALQDSESINQVQ
Function: Essential for viral replication in vivo . Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding (By similarity). PTM: Phosphorylated by host in infected cells . Phosphorylation is not essential for zinc binding activity and oligomerization, but zinc ...
P04545
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
Function: Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription . Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription . Preferentially binds ...
Q5MKM1
MSVRPCKFEVQGFCSRGRNCKYSHKYWEWPLKTLMLRQNYMLNRIYRFLDTNTDAMSDVSGFDAPQRTAEYALGTIGVLKSYLEKTNNITKSIACGSLITVLQNLDVGLVIQARDSNTEDTNYLRSCNTILSYIDKIHKKRQIIHILKRLPVGVLCNLIQSVISIEEKINSSMKTE
Function: Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to...
C0HKZ3
ECCRYVDCRRGCTPCC
Function: Has a sleep-inducing effect in mice when injected intraperitoneally. Sequence Mass (Da): 1867 Sequence Length: 16 Domain: The cysteine framework is III (CC-C-C-CC). Classified in the M-2 branch, since 2 residues stand between the fourth and the fifth cysteine residues. Subcellular Location: Secreted
Q02779
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKL...
Function: Activates the JUN N-terminal pathway. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 103694 Sequence Length: 954 EC: 2.7.11.25
Q66L42
MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKL...
Function: Activates the JUN N-terminal pathway. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 103187 Sequence Length: 940 EC: 2.7.11.25
Q7T2V3
MDGLPKDEAFLWQSSKDNKENGVWSDVQSYGVSNPLWMAVFDYEPTAEEELTLRRGDLVEILSKDSTVSGDEGWWTGKIKDKVGIFPSNYVVSDDKYTTLTGAPKQCPLPLEIEFDELNLDEIIGVGGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVRQEAKIFCMLCHPNIIALTGVCLKPPHLCLVMEYARGGPLHRALAGKKVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFNKTLNITDFGLAREWQKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE...
Function: Activates the JUN N-terminal pathway. Essential for pronephros and cement gland development. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence M...
Q16584
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEV...
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation ...
Q66HA1
MEPLKNLFLKSPLGSWNGSGSGGGGGSGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGE...
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation ...
Q12852
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW...
Function: Part of a non-canonical MAPK signaling pathway . Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 . May be an activator of the JNK/SAPK pathway. PTM: Autophosphorylated on Ser/Thr. Phosphorylated i...
O60476
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVG...
Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Catalytic Activity: 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)...
Q9UKM7
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHF...
Function: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trim...
A2AJ15
MYPPPAPPPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQLSRLQRNVILFVLGFLILCGFLYSLHTADQWKALSGRPAEVEKMKQEVLPVLPAPQKESAEQEGFADILSQKRQRHFRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQRTVISWRGAVIEPEQATELPYKRAEASIKPLVLASKIWKEPAPPNERQKGVIEAFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKQARKWVSENLDFQKNVDVNLFESTIRILGGLLSTYHLSGDSLFLTKAEDFGKR...
Function: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trim...
Q9NR34
MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGS...
Function: Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. Catalytic Activity: 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-...
P0CAY9
YQRXSRYYYYXGPPDDIDDRY
Function: May be specifically involved in the formation of the nacreous layer. PTM: According to PubMed:11250534, amino acids 4 and 11 may be sulfated or phosphorylated. By similarity with the N14 matrix protein, amino-acid 4 may be a cysteine involved in a disulfide bond. Sequence Mass (Da): 2728 Sequence Length: 21 S...
A2R6F5
MFAKLSLLSLLFSSAALGASNQTLSYGNIDKSATPEARALLKYIQLQYGSHYISGQQDIDSWNWVEKNIGVAPAILGSDFTYYSPSAVAHGGKSHAVEDVIQHAGRNGINALVWHWYAPTCLLDTAKEPWYKGFYTEATCFNVSEAVNDHGNGTNYKLLLRDIDAIAAQIKRLDQAKVPILFRPLHEPEGGWFWWGAQGPAPFKKLWDILYDRITRYHNLHNMVWVCNTADPAWYPGNDKCDIATIDHYPAVGDHGVAADQYKKLQTVTNNERVLAMAEVGPIPDPDKQARENVNWAYWMVWSGDFIEDGKQNPNQFLHK...
Function: Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da): 37700 Sequence Length: 335 Subcellular Location: Secreted E...
G2Q4H7
MARTLRYLLCGILALAAGSNAVPAARGSTRAAPAAEPSTSATTYEAEDAILSGTTVDTAQEGYTGSGYVTGFDEASDKITFEVESEATKLYDLSIRIAAIYGDKHTTVVLNGGASSDVSFPAGDTWVDVPAGQVLLNEGANTIEIVSNWGWYLVDSITLTPSAPRPEHQINRSLNNPSADASARALYDYLRSIYGKKILAGQQDLTWADYVTQQTGKTPALVSVDLMDYSPSRVERGTKGTSVEEAITHAERGGIVSALWHWNAPAGLYDTDEHPWWSGFYTDATDFDVAAALSSTDNANYTLLLRDIDAIAVQLKRLRD...
Function: Mannan endo-1,4-beta-mannosidase that exhibits high activity against konjac glucomannan and carob galactomannan, as well as a lower activity toward beta-mannan . Shows no activity against barley beta-glucan, birchwood xylan, and low viscosity carboxymethyl cellulose (CMC) . Has the ability to hydrolyze manno-...
Q8VHC8
MGASVLPLGLGAGDCQSSSGRRMSACLPRTALSFLLSLLLATPGARAAGYETCPMVQPGMLNVHLVAHTHDDVGWLKTVDQYYWGIHNDLQQAGVQYILDSVISALLAEPTRRFVYVEMAFFSRWWHQQTNETQEVVRRLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGVFFGRIDYQDKLVRKKRREMELVWRASASLKAPAADLFTGVLPNNYGPPEGLCWDVLCADPPVVDDPRSPEYNAKKLVSYFLQLATAQGRYYRTNHTVMTMGSDFQY...
Cofactor: Binds 1 zinc ion per subunit. Function: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Catalytic Activity: Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Sequence Mass (Da): 113184 Sequence Length: 1007 Subcellular Location: ...
O00754
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDF...
Cofactor: Binds 1 zinc ion per subunit. Function: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. PTM: First processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). The 70 kDa peptide is further processed into...
Q96GV9
MEVDINGESRSTLTTLPFPGAEANSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKAEAMPSLRSKQLDAGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMIKEPADTEVLQYQLQHLTLRGDRVFARNNT
Function: Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages . The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis . May also play a role in trafficking of proteins via its interaction with...
A0A2P1DP74
MCFFALEEWAAANRDYENTPAPYWHVKSVPDGFTAISGILWSISYILMAKKAFKDRSYAMPLHCLCLNITWEAVYGFVYGPGLLNQVVFAQWMIVDVVLFYAILRSAPYAWKQSPLVAQHLAGIIVVGCVICLWLHLAIAATFIPSIGRQVVFMTAWPMQVLINFSSIAQLLSRGNTLGHSWGIWWTRMLGTIAAACCFFWRIHYWPERFGYAWTPYGKFLLLGSIGSDMVYAAVYVYVQRIEKQLDSLVNTKAQKAR
Function: Terpene cyclase; part of the gene cluster that mediates the biosynthesis of macrophorins, isoprenoid epoxycyclohexenones containing cyclized drimane moieties . The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase macA . 6-MSA is then converted to m-cresol...
P91193
MMQQQKPGKPKKINRIDKIKRLQINRSRRPDINQTVPSPLFYVRIVVTWLGMVSLDAMTGFRFELLWPTWLMIRAAAESIQMRNQHCVTTIANPTAARFSVLFICVTATSDLICYLFIPIRMLIFLATTYVWISLYYHTQGGFLRSLATVYGGERLQSWPIVFITCFIVIFELFLRIRSHPILISFFPNVAEYAGVSPVWPRSLNAFFGAHSIGYPVILITVSMHYYFNEWKLRRKQCDVSNRNEQLFRILVEGLPAEYEGPKDYTSQQCLEDDLYYLDPPVQTLQPMQAIQAASATPPTSSKKNGIHKRNGDVTSSTTT...
Function: Plays a role in the regulation of neuronal activity. In AWA and AWC neurons, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl and isoamyl alcohol . May play a role in regulating daf-7 expression in ASI neurons in response to bacterial...
Q2TLY2
MKRRNADCSKLRRPLKRNRITEGIHSSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPKQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKHFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRQERETEEATSKGMSEADSVLVAQNGTAINKKLPISLPELEYKEKGKDSAKDKKQQQHSIGINNNILQTVDAKLQDIEYMENHLNAKRLNNELGGSAENLFLKEEVGAGGG...
Function: May play a role in the regulation of neuronal activity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 76082 Sequence Length: 664 Subcellular Location: Nucleus membrane
Q2TLY1
MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKHFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQLIQRQEREAEEAAAAAAAAASKSIHDVDSPAVAQNGSAGGKKPSSNTLPELEYREKERGKNESKKQHNHNQNHHSSTSSSILPSVDNKAQEMEYMENHVNSKRLSSSDLLGSTE...
Function: May play a role in the regulation of neuronal activity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 78344 Sequence Length: 699 Subcellular Location: Nucleus membrane