ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q8N5G2
MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILIHHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSK...
Function: Plays a role in the regulation of neuronal activity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 76178 Sequence Length: 664 Subcellular Location: Nucleus membrane
Q7TQE6
MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILIHHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSK...
Function: Plays a role in the regulation of neuronal activity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 76089 Sequence Length: 664 Subcellular Location: Rough endoplasmic reticulum membrane
O57342
MASELAMTAELPTSPLAIEYVNDFDLMKFEVKKEPAEAERLCHRLPAGSLSSTPLSTPCSSVPSSPSFCAPSPGGQPSAGPTAAPLGSKPQLEELYWMSGYQHHLNPEALNLTPEDAVEALIGAPHHHHHHHQSYESFRPQPFGGEELPPAAHHHNAHHHHHHHHLRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHILENEKCQLQSQVEQLKQEVSRLAKERDLYKEKYEKLAARGFPRETSPPAAPKTTAADFFM
Function: Transcription factor involved in transcription regulation during lens development, including that of crystallin genes . Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences . PTM: Phosphorylation at Ser-14 and Ser-65 is required for transcription regulation activity ...
Q8NHW3
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPGAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAGHGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGR...
Function: Transcription factor that activates insulin gene expression . Acts synergistically with NEUROD1/BETA2 and PDX1 . Binds the insulin enhancer C1/RIPE3b element . Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence . PTM: Ubiquitinated, leading to its degradation by the proteasome. Sequence Mass (D...
D3ZNT6
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGSSAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHSAHHGAHHPAAAAAYEAFRGQSFAGGGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKE...
Function: Transcription factor that activates insulin gene expression . Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element . Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity). PTM: Ubiquitinated, leading to its degradation by th...
Q7ZV50
MLHKLLIVVFLVVCLHDMRLNGQKKKETLLSEKVSQMMEWVSKRAVVRLNGEKFKRLVRAHPRNYSVIVMFTALQPQRQCGVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRADTYELQVRGFAAEQLARWVADRTDVHIRVIRPPNYAGPLMLGLLLAFIGSLAYLRRNNLEFLFNKNVWAFSALCFVLIMTSGQMWNHIRGPPYAHKNPNTGQVSYIHGSSQAQFVAETHIVLLFNAAVTIGMVLLHEAATSGLDIVKRKIMCVAGIGLVVLFFSWLLSVFRAKYHG...
Function: Cell surface magnesium transporter. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37422 Sequence Length: 328 Pathway: Protein modification; protein glycosylation. Subcellular Location: Cell membrane
Q9H0U3
MAARWRFWCVSVTMVVALLIVCDVPSASAQRKKEMVLSEKVSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSI...
Function: Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains . Involved ...
P02916
MDVIKKKHWWQSDALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKTYNFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKETTAQPEGERANLRVITQNRQALSDITAILPDGNKVMMSSLRQFSGTQPLYTLDGDGTLTNNQSGVKYRPNNQIGFYQSITADGNWGDEKLSPGYTVTTGWKNFTRVFTDEGIQKPFLAIFVWTVVFSLITVFLTVAVGMVLACLVQWEALRGKAVYRVL...
Function: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 57013 Sequence Length: 514 Subcellular Location: Cell inner membrane
O51924
MDNNLTSKLKYREAKLGYLMILPLLTVVLVFIILPVMGTFWISLHRDVTFIPEKPFVGLRNYLRVLSAREFWYSTFVTVSFSFVSVSLETILGLSFALILNERLKGRGVLRAIVLIPWAVPTIISARTWELMYNYSYGLFNWILSILGVSPVNWLGTPISAFFAIVIADVWKTTPFMTLLLLAGLQAIPQDLYEAALIDGASMFERFKSITLPLLKPVLIVALILRTIDALRVFDIIYVLTGGGPGGATTSISLLAFNYYNLGDYGIGSAISILTFVLVLSFTIVYLKVGRFRRD
Function: Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33054 Sequence Length: 295 Subcellular Location: Cell membrane
Q0DM48
MTVRPRPAAAAIIIAAVFGAAAAAAGGGMVGVDGTQFVVEGGRTIYFSGFNAYWLMMMASDPARRAAVVAAFAQASSRGLNLARTWAFSDGGDQPLQSSPGVYDEAMFQGLDFVIAEARRHGIYLLLCLTNNFDDFGGKRQYVRWAADAGHNLTAGDDFFTSSVVKSYYKNHVKAVLTRVNTVTGVAYKDDPTIFAWELMNEPRCDADPTGGMVQAWVEEMAPYVKRVDGGRHLVTAGLEGFYGDGEHESKELNPWGIYYGTNYVATHRAAGVDFATIHLYPDVWLWGSTADEQAAFFRNWTRSHVHDTAAFLGKPLLVT...
Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da): 51217 Sequence Length: 468 Subcellular Location: Secreted EC: 3.2.1.78
Q8L5J1
MNNSIILIFVAILIIFPNEFSKPTRAFSNNNFVYTDGTHFALNGKSLYINGFNAYWLMYIAYDPSTRIKVTNTFQQASKYKMNVARTWAFSHGGSRPLQSAPGVYNEQMFQGLDFVISEAKKYGIHLIMSLVNNWDAFGGKKQYVEWAVQRGQKLTSDDDFFTNPMVKGFYKNNVKVVLTRVNTITKVAYKDDPTILSWELINEPRCPSDLSGKTFQNWVLEMAGYLKSIDSNHLLEIGLEGFYGNDMRQYNPNSYIFGTNFISNNQVQGIDFTTIHMYPNQWLPGLTQEAQDKWASQWIQVHIDDSKMLKKPLLIAEFG...
Function: Possesses endo-beta-mannanase and mannan transglycosylase activities. May be involved in cell wall degradation during fruit ripening. Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da): 45339 Sequence Length: 399 Subcellul...
B3PF24
MSLFTPLSETNVRSHTNTSSVFCRRIKTLVAGLTALGLMLAAVSASAGFYVSGKQLREGNGNNFIMRGVNLPHAWFPDRTNQALADISATGANSVRVVLSNGRLWSRTPESQVASIISQAKARQLITVLEVHDTTGYGEQTAATLSEAVDYWIAIRNALIGQEDYVIINIGNEPFGNGQSASTWLNLHRDAINRLRNAGFTHTLMVDAANWGQDWENIMRNNASSLFNSDPRRNVIFSVHMYEVYPNDTAVNNYMSAFNSMNLPLVVGEFAANHFGSYVDAGSIMARAQQYGFGYLGWSWSGNSSNLSALDVVTNFNAGS...
Function: Catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan. It is able to hydrolyze mannosidic linkages that are flanked by mannose or glucose. Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da)...
G1K3N4
AGFYVDGNTLYDANGQPFVMRGINHGHAWYKDTASTAIPAIAEQGANTIRIVLSDGGQWEKDDIDTIREVIELAEQNKMVAVVEVHDATGRDSRSDLNRAVDYWIEMKDALIGKEDTVIINIANEWYGSWDGSAWADGYIDVIPKLRDAGLTHTLMVDAAGWGQYPQSIHDYGQDVFNADPLKNTMFSIHMYEYAGGDANTVRSNIDRVIDQDLALVIGEFGHRHTDGDVDEDTILSYSEETGTGWLAWSWKGNSTEWDYLDLSEDWAGQHLTDWGNRIVHGADGLQETSKPSTVFTDDNGGHPEPPT
Function: Catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan. It is able to hydrolyze mannosidic linkages that are flanked by mannose or glucose. Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da)...
Q9LZV3
MKDQLGFRIVLCSAVFIILTQNRALADLDSESHEVNSESVGEEQWEMVQRKGMQFTLNGQPFYVNGFNTYWMMTLAADNSTRGKVTEVFQQASAVGMTVGRTWAFNDGQWRALQKSPSVYDEEVFKALDFVLSEARKYKIRLILSLVNNWDAYGGKAQYVKWGNASGLNLTSDDDFFTNPTLRNFYQSHVRTVLNRVNTFTNITYKNDPTIFAWELMNEPRCPSDPSGDKLQSWIQEMAVFVKSLDAKHLVEIGLEGFYGPSAPARTRFNPNPYAAQVGTDFIRNNQVLGIDFASVHVYPDSWISPAVSNSFLEFTSSWM...
Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da): 50622 Sequence Length: 448 Subcellular Location: Secreted EC: 3.2.1.78
Q0DCM5
MRQERRLYSLLGLLLLLAVVYLTWFPTTHDGGGGGGGGWVKLPVPWLQPRMPFAARRGTHFVDADTGSPLYVNGWNSYWLLPARSPALAAEMLRRGRRMGLSVCRTWAFSDGGPGALQISPGRFSEAVFQVLDYVIYEARRNHIRLILCLVNNLDNLGGKAQYVQWAQAAGANMTNSTDSFYSHPTIKRYYKDYVKAILTRRNSYSRIRYSDEPAIFAWELMNEPRCVSNSSGPYLQAWIAEMAAYVKSLDTNHLVTVGTEGFYGPGIAERLGVNPGEWAASLCSDFIQNSAVEHIDFASVHAYPDSWLPRASLEEKVRY...
Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans. Sequence Mass (Da): 49455 Sequence Length: 440 Subcellular Location: Secreted EC: 3.2.1.78
Q9FJZ3
MKLLALFPFLAIVIQLSCWELGTDALPSGGFVRTKGVQFSLNGYPYYANGFNAYWLMYVASDPSQRSKISTAFQDASRHGLTVARTWAFSDGGYRALQYSPGSYNEDMFQGLDFALAEARRHGIKIILSFANNYESFGGRKQYVDWARSRGRPVSSEDDFFTDSLVKDFYKNHIKAVLNRFNTFTKVHYKDDPTIMAWELMNEPRCPSDPSGRAIQAWITEMAAHVKSLDRNHLLEAGLEGFYGQSSPQSKTLNPPGQFGTDFIANNRIPGIDFVTVHSYPDEWFPDSSEQSQMDFLNKWLDAHIQDAQNVLHKPIILAE...
Function: Required for both, loosening of the micropylar endosperm, and rupture of the seed coat in germinating seeds. May participate in the hydrolysis of the mannans in the cell wall of germinating seeds. Catalytic Activity: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucoma...
P94078
MAVKCFSLYLILAAIVIGGVTSEYIEYNTKPRIVPEKINVHLVPHSHDDVGWLKTVDQYYVGSNNSIRGACVQNVLDSVIASLLDDENRKFIYVEMAFFQRWWRQQSNAKKVKVKKLVDSGQLEFINGGMCMHDEATPHYIDMIDQTTLGHQFIKTEFGQVPRVGWQIDPFGHSAVQAYLLGAEFGFDSLFFARIDYQDRAKRLREKTLEVIWQGSKSLGSSSQIFTGVFPRHYDPPEGFTFEINDVSAPIQDDPLLFDYNVQERVNDFVAAALAQVNVTRTNHIMWLMGTDFRYQYAYSWFRQIDKFIHYVNKDGRLNV...
Cofactor: Binds 1 zinc ion per subunit. Function: Liberates mannose from p-nitrophenyl-alpha-D-mannoside in vitro. Catalytic Activity: Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Sequence Mass (Da): 115220 Sequence Length: 1019 EC: 3.2.1.24
O31646
MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQNGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEYANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKPGDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIEVPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEGRMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL
Cofactor: Binds 1 zinc ion per subunit. Catalytic Activity: D-mannose 6-phosphate = D-fructose 6-phosphate Sequence Mass (Da): 36003 Sequence Length: 315 EC: 5.3.1.8
P24174
MAQSKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVVICNEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAAKRHSPESDPLMLVLAADHVIADEDAFRAAVRNAMPYAEAGKLVTFGIVPDLPETGYGYIRRGEVSAGEQDMVAFEVAQFVEKPNLETAQAYVASGEYYWNSGMFLFRAGRYLEELKKYRPDILDACEKAMSAVDPDLNFIRVDEEAFLACPEESVDYAVMERTADAVVVPMDAGWSDVGSWSSLWEISAHTAEGNVCHGDVINHKTENSYVYAESGLV...
Function: Involved in the biosynthesis of the capsular polysaccharide colanic acid. Catalytic Activity: alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose Sequence Mass (Da): 53016 Sequence Length: 478 Pathway: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannos...
Q5AZ53
MIFSTLLSLALLATTATARKGFVTTKGDKFQLDGKDFYFAGSNAYYFPFNNNQTDVELGLSAAKKAGLLVFRTWGFNDKNVTYIEDGLPQYGGEGAGTTEVVFQWWQNGTSTIDLEPFDKVVNAAAKTGIKLIVTLVNNWADYGGMDVYTVNLGGQYHDDFYRLPQIKKAYKRYVKEMVTRYRNSPAIMAWELANEPRCGADGVRNLPASDECTPELLTSWIDEMSTYVKRLDPHHLVTWGGEGGFNYDSDDWAYNGSDGGDFEAELKLKNIDFGVFHSYPDWWSKTVEWTNKWIVDHARAARRVGKPVVHEEYGWLTPQ...
Function: Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and gum guar . Also has transglycosylation activity. Produc...
Q8FHC7
MHHDKRCKESNMKIVKAEVFVTCPGRNFVTLKITTEDGITGLGDATLNGRELSVASYLQDHLCPQLIGRDAHRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAANMPLYQLLGGASREGVMVYCHTTGHSIDEALDDYARHQELGFKAIRVQCGIPGMKTTYGMSKGKGLAYEPATKGQWPEEQLWSTEKYLDFMPKLFDAVRNKFGFDEHLLHDMHHRLTPIEAARFGKSIEDYRMFWMEDPTPAENQECFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTLTHAGGITGMRRIADFASLYQV...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro). Catalytic Act...
A4XF23
MKITAARVIITCPGRNFVTLKIETDQGVYGIGDATLNGRELSVVAYLQEHVAPCLIGMDPRRIEDIWQYVYRGAYWRRGPVTMRAIAAVDMALWDIKAKMAGMPLYQLLGGRSRDGIMVYGHANGSDIAETVEAVGHYIDMGYKAIRAQTGVPGIKDAYGVGRGKLYYEPADASLPSVTGWDTRKALNYVPKLFEELRKTYGFDHHLLHDGHHRYTPQEAANLGKMLEPYQLFWLEDCTPAENQEAFRLVRQHTVTPLAVGEIFNTIWDAKDLIQNQLIDYIRATVVGAGGLTHLRRIADLASLYQVRTGCHGATDLSPV...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). Catalytic Activity: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O Sequence Mass (Da): 45244 Sequence Length: 402 Pathway: Carbohydrate metabolism;...
P19994
MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIAERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGYHGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFSVVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNWTVVTVDGKKCAHFEHTIAITETGFDILTRV
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
Q4QRK0
MAAVETRECETEGCHSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKEDKTNDEEKNCVEKEVNTDPWPGYRYTGKLRPYYPLTPMRLVPSNIQRPDYADHPLGMSESEQTMKGTSQIKILNAEEIEGMRVVCKLAREVLDIAAMMVKPGVTTEEIDHAVHLACTARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRHLQEGDILNIDITVYHNGYHGDLNETFFVGEVDEGAKRLVQTTYECLMQAIDSVKPGIRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKPG...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the acti...
Q54WU3
MEGILCASPGCGKPAKLQCPTCVNLKLETPSHFCSQECFKTFWPLHKMYHQKGQPENLPSQFRNYKFTGPLRPTNITPMRKAPEGIELPDYAIGSIPISERVADRKNMANIIHTPEEIEIMRQLGKMSREVLDIAGNAAKVGMTTEELDIIVHNAVIERGAYPSPLNYYKFPKSCCTSLNEVICHGIPDERPLRDGDILNVDVTLYWKGFHSDLNETYLIGNVDERGKNLVKCAYDCLELAVAMCKPGTLYRELGDAIQKHANKQGFSVVKNFCGHGIGRLFHCNPTVPHYSKNKAVGAMKVGHVFTIEPMINEGTWQDE...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the acti...
P53582
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKS...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the acti...
P9WK20
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIRESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTTADGSRAAHWEHTVAVTDDGPRILTLG
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
P53579
MGDTITLLSRREIEKMRQAGQLAAALLDHLAPMVQPGITTLELNDEAEKWTKAHGAISAPLGYNGFPKSICTSINEVICHGIPHRKRVLQAGDIINVDVTPIVDGYHGDCSRTFFVGTPSPVAEKLVKVTEECLRLGIEAVKPGGKIGDIGAAIQSHAEAQGFSVVRDFVGHGISKIFHTAPQIPHYGKAGKGKRLRPGMVFTIEPMINEGTWEAVLLDDGWTAITKDGKLSAQFEHTIAVTEDGVEILTLGE
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
O34484
MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGKAVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGFYSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFTVIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDGWTFKTPDKSMVAQVEHTIVITKDEPIILTKL
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
Q4VBS4
MAAPCAAQCLYRTGGLRLLQRISRLPHCHKDASLAHQCQFHRSFFWRKPKTSHSVVRPAIVRPAYPVPKHIQRPDYVSSSKVPEWPDYIEIKDEEQIQGLRRACQLARHILLLTGNSLKVGMTTDEIDFIVHQEAIRHNGYPSPLHYGGFPKSVCTSVNNVVCHGIPDSRPLQDGDIINIDVTVYLEGYHGDTSETFLIGSVNDQGRKLVDVARQCRDQAIAACGPGQPLCVIGNIISNIANSNGFRVCPYFIGHGIGEYFHGHPEIWHHANDNDLKMEEGMSFTIEPILMEGTSGFRILSDKWTAVSVDDKRSAQFEHT...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
Q54VU7
MNKILKNIINKSSINNVFKTSFNGGISSSSSSSSSYLNNNNNIIKSYNVQQKQQQRYYSSFEDDLSPKKLKEKILENETEEIRDFVRSQRLTKKTASPLEGMNRKERRKMTTKLYRNPDNLIRGGIVSPQPLIPAHIKKPKYVLGEPVIDFEIDDPIEIHTAESIEHMRVVGKMAKEVLEYAGTLVRPGITTDEIDKLVHQNIIDRGAYPSPLGYKGFPKSICTSINEVLCHGIPDDRPLEFGDIVKIDVTLYYNGYHGDTCATFPVGEIDSSSKRLIEATEKALYAAIGEVKDGALFNKIGKKIQLVANKYSLSVTPEF...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
Q6UB28
MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSSQQRRNFFFRRQRDISHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLI...
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
P9WK18
MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
Q96JE9
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAK...
Function: Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B . Regulates KIF5A...
Q63560
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPAPPQPGLAPPSRAVAIETQPAQGESDAVARATGPAPGPSGDRETAAAPGRSGLGLGAASGSTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQIPATSQPSPPVLGMPKRRPQSQERGPIQLSADARDPEGAGGAGVPAAGKASGADQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKAS...
Function: Involved in microtubule stabilization in many cell types, including neuronal cells . Specifically has microtubule cold stabilizing activity . Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axona...
Q14244
MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPK...
Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in ...
O88735
MAEQGAGGDGHRGGDGATHSDPASDGYKVQEKRTAPSRPTSTVSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPRQKSNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCSPIIMPFKAAHSRNPVDRPKLFVTPPEGSARRRTIHGLASHKREREREHVPFHVSPGARRTLSPSNL...
Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in ...
Q9FLS8
MEAEKSKQNPGKKPVEATMEHVLVALRETKEKREIRIQKLFEFFDNSKLGFLDDTQIEKGLSSLSIPPKYRYASDFLKVCDSNRDGRVDYQEFRRYMDAKELELYKIFQAIDIEHNGDICPAELWEALDKAGIKIKDEELASFMEHVDKDNNGIITFEEWRDFLLLNPHEATIENIYHHWERVCLIDIGEQAVIPDGISAHAQRSKLLLAGGIAGAVSRTATAPLDRLKVALQVQRTNLGVVPTIKKIWREDKLLGFFRGNGLNVAKVAPESAIKFAAYEMLKPIIGGADGDIGTSGRLLAGGLAGAVAQTAIYPMDLVK...
Function: Calcium-dependent mitochondrial carrier protein that catalyzes the import of ATP co-transported with metal divalent cations across the mitochondrial inner membrane in exchange for phosphate (Pi) . Can transport phosphate, AMP, ADP, ATP, adenosine 5'-phosphosulfate and, to a lesser extent, other nucleotides . ...
Q9FI43
MEATKSSKQNCCNPVKKPGPVSIDHVLLALRETREERDLRIRSLFSFFDSENVGYLDCAQIEKGLCALQIPSGYKYAKELFRVCDANRDGRVDYHEFRRYMDDKELELYRIFQAIDVEHNGCISPEGLWDSLVKAGIEIKDEELARFVEHVDKDNDGIIMFEEWRDFLLLYPHEATIENIYHHWERVCLVDIGEQAVIPEGISKHIKRSNYFIAGGIAGAASRTATAPLDRLKVLLQIQKTDARIREAIKLIWKQGGVRGFFRGNGLNIVKVAPESAIKFYAYELFKNAIGENMGEDKADIGTTVRLFAGGMAGAVAQAS...
Function: Calcium-dependent mitochondrial carrier protein that catalyzes the import of ATP co-transported with metal divalent cations across the mitochondrial inner membrane in exchange for phosphate (Pi) . Can transport phosphate, AMP, ADP, ATP, adenosine 5'-phosphosulfate, sulfate and thiosulfate, and, to a lesser ex...
Q9LY28
MESSKPKNRNPMKKPVSITMEHVLLALRETMDEREIRIRSLFDFFDNSNLGFLDYAQIEKGLASLQIPPEYKYARDLFRVCDANRDGRVDYQEFRRYIDAKELELYRIFQAIDVEHNGCILPEELWEALVKAGIEIDDEELARFVEHVDKDNNGTITFEEWRDFLLLYPHEATLENIYHHWERVCLIDIGEQAVIPDGISKHVKRSRLLLAGGLAGAVSRTATAPLDRLKVVLQVQRAHAGVLPTIKKIWREDKLMGFFRGNGLNVMKVAPESAIKFCAYEMLKPMIGGEDGDIGTSGRLMAGGMAGALAQTAIYPMDLV...
Function: Calcium-dependent mitochondrial carrier protein that catalyzes the import of ATP co-transported with metal divalent cations across the mitochondrial inner membrane in exchange for phosphate (Pi) . Can transport phosphate, AMP, ADP, ATP, adenosine 5'-phosphosulfate, sulfate and thiosulfate, and, to a lesser ex...
O94737
MDSKHSVFNVMGQEFVLQKGYEVIKGLGKGSYGVVCSAKNIEVEDNNKVAIKKITNIFSKKMLAKRALREIMLLQHFRNHKNITTLYDMDIVDPSKFNELYLYEELMQANLNSIIRSDQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPSNLLINADCKLKICDFGLSRGISVNQGQGTEYMTEYVTTRWYRAPEVMLSFQSYSKAIDLWSVGCILAELLGRKPFFKGSNYVDQLNQIFCILGTPNENIISKIKSASAQSYIRSLPTLPKMPYSKIFPYANPDALDLLNCLLTFDPYDRISCEEALEHPYLIIWHDP...
Function: Serine-threonine protein kinase which may be involved in maintenance of cell integrity. Functionally complements SLT2 null mutant in S.cerevisiae. PTM: Dually phosphorylated on Thr-186 and Tyr-188, which activates the enzyme. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protei...
P49071
MLSLQNQRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMR...
Function: Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). PTM: Phosphorylated and activated by MAP kinase. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 41401 Sequence Length: 359 EC: 2.7.11.1
P0C1Q5
INWKALLDAAKKVL
Function: Potent antimicrobial peptide and potent mast cell degranulating peptide . Is active on both Gram-negative bacteria (E.coli MIC=7.8 ug/ml, and P.aeruginosa MIC=62.5 ug/ml) and Gram-positive bacteria (S.aureus MIC=15.6 ug/ml, and B.cereus MIC=7.8 ug/ml) . Its mast cell degranulation activity may be related to t...
P0C022
INLLKIAKGIIKSL
Function: Antimicrobial and mast cell degranulating peptide. Shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S.aureus ATCC 6538 (MIC=5 ug/ml), S.saprophyticus CS (MIC=5 ug/ml), S.epidermidis CS (MIC=5 ug/ml), B.subtilis CCT 2471 (MIC=40 ug/ml), and the Gram-negative bacteria E.coli CCT 13...
P0DRA7
INWLKLGKKMMSAL
Function: Antimicrobial peptide. Has activity against both Gram-positive and -negative bacteria (B.subtilis (MIC=9 uM), E.coli (MIC=65 uM)). Shows mast cell degranulation activity (EC(50)=15-26 uM). Has low hemolytic activity (IC(50)=100 uM) . Its mast cell degranulation activity may be related to the activation of G-p...
A1T9P9
MTDRVTVGNLRVAPVLYDFINNEALPGTDIDPDTFWSGVDKVVADLTPRNQDLLARRDDLQAQIDRWHRARVIGGFEPEDYKQFLTDIGYLEPEPADFSITTAGVDDEITTTAGPQLVVPILNARFALNAANARWGSLYDALYGTDVISDEGGAEAGSGYNPVRGDKVIAYARRFLDGAVPLASGSWSDITGLKLDEGQLAATLDDGGTVGLGTPEQFVGYLGDAEAPTAVLLVNNGLHIEILIDAEAPIGATDKAGIKDVVLESAITTIMDFEDSVAAVDADDKVLGYRNWLGLNRGDLAEEVSKGGKTFTRVLNSDRT...
Function: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA. Catalytic Activity: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+) Sequence Mass (Da): 79327 Sequence Length: 734 Pathway: Carbohydrate ...
Q50418
MSIDAKLSRQASGSKAGVACVPDAYSFSEARSPGTRFALMLSAVAAGLAGGAMLHSAMSATSALTGLFIVLALAGGFLSTWSPCGYSSLSLLRPAGRYSFASVLRWSPTFFTHALGYAIGAVVLGGALGMAGWLLFSSLPFSYMVAGMAVLALGYGAHQFGFMKMPYPQRRAQVPHDARFRFRSSVIGLLYGYALGMNYLTYVQTPILYIVTGVALFCGDVKTAIVIIGIFNIGRCLPVAVNFLPVKNVTVQVWLARWQERAVEVDGFLLLSVGSAALMLLVL
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30033 Sequence Length: 283 Pathway: One-carbon metabolism; methylamine degradation. Subcellular Location: Cell membrane
Q50230
MSMNIGATAMSRSSQAYAVETCVPDAYHFSKAQSTGTRFIMMLTAVASGVFAGRVMHSTMSVEMALTGLFVVLAFVGGLLSTWSPCGYSSLSLLRPAGRYSLGAVTRWAPTFFTHAVGYAIGAVVLGGALGGISWLLFADVPLQYAVIGLATLAIGYGLHQFGFLKMPYPQRRAQVPHDARFRFRSSVIGLLYGFSLGMNYLTYVQTPMLYIVTGVALLSGGVKAGIAVIAVFNIGRCLPVAVNFLPVKDQSVQAWLARWQESAVEVDGFLLLAIASAALMLVML
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30429 Sequence Length: 285 Pathway: One-carbon metabolism; methylamine degradation. Subcellular Location: Cell membrane
Q56463
MASLDNFDMAAGRTDGVADCVAFPGRFSTWTRALILAASAAGGGAAALAMDAAHVALVLGLAAFAGGLLSTWSPCGYSSISLLRPTGKGARAVLDWLPTFATHGLGYALGALILGTLLGAIGGIAGLSGFATSFGLGLLAVIGLAYGAHQLDFLRVPYPQRRAQVPHDARQRFPKWVVGGLYGLSLGLDYLTYVQTPLLYLVTAAAVLSGNVAEAVALIAIFNLGRYLPVAVNLLPVTDYQIQSWLGRNQERAAIADGAILTAVGAAFAMLALA
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28174 Sequence Length: 274 Pathway: One-carbon metabolism; methylamine degradation. Subcellular Location: Cell membrane
Q49128
MRAILPIPVLIAWAMVVCGGAYAVTTCSGAATATADASQQDLAALKARFRRPESVPHPKANPLTPEKVALGKALFFDPRLSRSGSVSCATCHNPSLGWSDGLTRAVGFGMVPLPRRTPPVLNLAWGTAFQWDGRADSLEAQARMPITAPDEMNMSMDLVVERLKAVPGYAPLFRNAFGSEEPIGARHVTAALATFQRTLVSGEAPFDRWALGDESAIGADAKRGFALFTGKAGCAACHSTWRFTDDSFHDIGLKAGNDLGRGKFAPPSVTAMRYAFKTPSLRDLRMEGPYMHDGQLGSLEAVLDHYIKGGEKRPSLSFEM...
Function: Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH. PTM: Binds 2 heme c groups covalently per subunit. Sequence Mass (Da): 38146 Sequence Length: 353 Pathway: One-ca...
Q50233
MLFRHLVLIISTLMVANTAWSANLPPREKFKRPDSIPAPLSNPLTLEKATLGKTLFFDQRLSRSGGMACATCHSPDQRWSDGRTLPLQAESVSNARRTPTVLNSAWLSALMWDGRATTLEEQAVLPITTAHEMNFDLASLVSRLQRIEGYRPLFTQAFGDDSISQQRITQALASFQRTLVSNIAPFDRWVAGDEQAISESAKRGFAVFNDKNKANCVACHSSWRFTDDSFHDIGLPSKDLGRGAKVPSQVTLMQHAFKTPSLRDLSIDGPYMHDGSIRGLKTVIKHYKSEAIQRESLSKDMQKFELSNLEESDLIAFIQS...
Function: Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH. PTM: Binds 2 heme c groups covalently per subunit. Sequence Mass (Da): 37265 Sequence Length: 335 Pathway: One-ca...
Q51658
MLRLACLAPLAILIPAAGTAEQARPADDALAALGAQLFVDPALSRNATQSCATCHDPARAFTDPREGKAGLAVSVGDDGQSHGDRNTPTLGYAALVPAFHRDANGKYKGGQFWDGRADDLKQQAGQPMLNPVEMAMPDRAAVAARLRDDPAYRTGFEALFGKGVLDDPERAFDAAAEALAAYQATGEFSPFDSKYDRVMRGEEKFTPLEEFGYTVFITWNCRLCHMQRKQGVAERETFTNFEYHNIGLPVNETAREASGLGADHVDHGLLARPGIEDPAQSGRFKVPSLRNVAVTGPYMHNGVFTDLRTAILFYNKYTSR...
Function: Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH. PTM: Binds 2 heme c groups covalently per subunit. Sequence Mass (Da): 42230 Sequence Length: 387 Pathway: One-ca...
P15283
MSDIETFYDVMRRQGITRRSFMKSVRSPQHVLGLGPSFVPKIGEAMETKPRTPVVWVHGLECTCCSESFIRSAHPLAKDVVLSMISLDYDDTLMAAAGHAAEAAFEETIAKYKGNYILAVEGNPPLNEDGMFCITGGKPFVEKLRHAAEGAKAIISWGACASYGCVQAAAPNPTQATPVHKVITDKPIIKVPGCPPIAEVMTGVITYMLTFDRMPELDRQGRPAMFYSQRIHDKCYRRPHFDAGQFVEHWDDENARKGYCLYKMGCKGPTTYNACSTVPLERRRHFPIQSGHGCIGCSEDGFWDQGSFYDRLTTIKQFGI...
Cofactor: Binds 1 [3Fe-4S] cluster. Function: This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Catalytic Activity: A + H2 = AH2 Location Topology: Peripheral membrane pro...
P31884
MLEEKGIERRDFMKWAGAMTAMLSLPATFTPLTAKAAELADRLPVIWLHMAECTGCSESLLRTDGPGIDSLIFDYISLEYHETVMAAAGWQAEHNLEHAIEKYKGRYVLMVEGGIPAGSSEFYLTVGPHGTTGAEHARHASANAAAIFAIGSCSSFGGVQAARPNPTNAQPLSKVTNKPVINVPGCPPSEKNIVGNVLHFILFGTLPSVDAFNRPMWAYGLRIHDLCERRGRFDAGEFVQEFGDEGAKKGYCLYKVGCKGPYTFNNCSKLRFNQHTSWPVQAGHGCIGCSEPDFWDTMGPFEEPVANRLYATAFDGLGAD...
Cofactor: Binds 1 [3Fe-4S] cluster. Catalytic Activity: a menaquinone + H2 = a menaquinol PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Location Topology: Peripheral membrane protein Sequence Mass (Da): 38294 Sequence Length: 354 Subcellular...
P69743
MTGDNTLIHSHGINRRDFMKLCAALAATMGLSSKAAAEMAESVTNPQRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLEYHEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKDNGIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAAAGVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHIITYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAKEFGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWPVAIGHPCYGCNEEGIGFHKGIHQLANVENQTPRSQ...
Cofactor: Binds 1 [3Fe-4S] cluster. Function: This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. Catalytic Activity: A + H2 = AH2 PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not...
Q35127
MRLLKSHPLLKLVNSYLIDASQPSNISYLWNFGSLLACCLIIQIVTGVTLAMHYSPNVLEAFNSIEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGMYYGSYRAPRTLVWAIGTVILILMMATAFLGYQHSPKWFDISNKGSISNKGNITNSLPPLLQRWGGRINKRLFNKNLVKRGYCTSSSLNSPEMSERLQTIINELGINPVYVYEDLNQPSSWKQILHDTRDLSGVYMIINKTTKDYYIGSASNNRFYTRFCNHVIHFTGSKIVKLAIKKYELKNFAFVILDLYPNVVTKENNKELLDLEDKYLKLLVPNYN...
Function: Mitochondrial DNA endonuclease involved in intron homing. PTM: The mature protein may arise from proteolytic cleavage of an in-frame translation of cob exon 1 plus intron 1, containing the bI1 open reading frame. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 51648 Sequence Length: 448 Sub...
P03873
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGNMNIASNMFNMMKTIYMMMLMLLIYIFYTIMMRQMMKTKEYTMLIKSMDYINKNKYMINLNMTNKKDMNNNIGPLNMNILSIIYGSMLGDGHAEKRKGGKGTRIVFQQEYCNINYLYYLHSLLANLGYCNTNLPLIKTRLGKKGKIRQYLKFNTWTYDSFNMIYSEWYIKNMSGKGN...
Function: This protein is responsible for splicing and maturation of cytochrome b mRNA. Specifically, it may be responsible for the splicing specificity of the second intron. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49326 Sequence Length: 423 Subcellular Location: Mitochondrion inner membrane
A9RAG7
MTIRKSNPYLSLVNSYLMDSPQPSSMNYWWNVGSLLGLCLVMQMASGMFLAMHYSSSMELAFNSVEHMMRDVNAGWLMRYIHANGASFFFMCLYLHMGKALYYGSYKSPRVLVWSMGVMMFMLTMATAFMGYCLVYGQMSHWGATVITNLLSAMPFMGGDLVPLSIILSLYLLYISLKTFMKMIFNQSYMCPAKGWVKKVLDNTFCIKKYMHMYLSSRTSPXLYINTMSNMQHMKIMSTKSHTKDRDTSFLEKDIKNMDRNLLALMVGFMDGDGYIRMNKKSKDNMNYIYMSLIMNLNKNDLKLLQYFHQQLNMGKVYNM...
Function: Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (COB) gene, containing its own coding sequence. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61859 Sequence Length: 522 Subcellular Location: Mitochondrion inner membrane
P0CY43
MRLLKSHPLLKLVNSYLIDASQPSNISYLWNFGSLLACCLIIQIVTGVTLAMHYSPNVLEAFNSIEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGMYYGSYRAPRTLVWAIGTVILILMMATAFLGYVLPYGQMSLWGATVITNLISAIPWIGQDIVESKIITLIINLSFIAILFSIVVVYYYILLHVNFSSNLPTIGVIHQNALKKSNKALRLDKQEYISIPSSFLAFLAGLVDGDGYIQVTKTSKGFIAIKLVISLHLEDLSILEYIHSVLKIGKINIYKDLRSPTCKLVINKTDLQEILFPLLMYNKIFFLT...
Function: Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (cob) gene, containing its own coding sequence. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54555 Sequence Length: 477 Subcellular Location: Mitochondrion inner membrane
Q9ZZW7
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFNMEDPYYSNMMLNKSVLCWNIFIWMMNYYIIQLIIYNNMIWNKNNMVKMFIMRRKLAVINMYMYMKLIIQRTYSYYMNNTIIYDKNHKLNTDNPIYAYIGGLFEGDGWITISKKGKYLLYELGIEMHIRDIQLLYKIKNILGIGKVTIKKL...
Function: Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (COB) gene, containing its own coding sequence. In vivo splicing requires the formation of a ribonucleoprotein complex together with the imported mitochondrial RNA-splicing protein MRS1. The complex seems to stimulate the intrin...
P03879
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFSVSNPTIQRFFALHYLVPFIIAAMVIMHLMALHIHGSSNPLGITGNLDRIPMHSYFIFKDLVTVFLFMLILALFVFYSPNTLGQNMALLLITYVINILCAVCWKSLFIKYQWKIYNKTTYYFIIQNILNTKQLNNFVLKFNWTKQYNKMNI...
Function: Mitochondrial mRNA maturase required for splicing of intron 4 of the cytochrome b (COB) gene, containing its own coding sequence, and intron 4 in COX1, coding for the related homing endonuclease aI4. In vivo splicing requires in addition the imported mitochondrial leucyl-tRNA synthetase NAM2. Both proteins se...
Q8WQL7
MNTADVPDNLQSWGQQPSSSYSNTQQHSQMTNLPPINHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQQHIQQQNAQRFIAQSRQPHSNILRFPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQFSTDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSGASLTDTFSIHNAIPITSSDNHYQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDDQNYDYILKNGE...
Function: Possible role in the function of olfactory neurons. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 101244 Sequence Length: 882 Subcellular Location: Nucleus EC: 2.7.12.1
Q73ZP8
MSAATTADIDHYRTVLAGAFDDQVLEWTREAEARQRFPRELIEHLGARGVFSEKWCGGMLPDVGKLVELARALGRLSSAGIGVGVSLHDSAIAVLRRFGKSDYLRDICERAIAGQAVLCIGASEESGGSDLQIVRTEMSSRDGGFDIRGVKKFVSLSPIADHIMVVARSIDHDSASKHGNVALIAVPTSQASVQRPYAKVGAGPLDTAAVHIDTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMTRRQFGRTLFEHQALRLRMADLQARVDLLQHGLNGIAAQGRLDLRAAAGVKVTAARL...
Function: Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is further transferred to the epsilon-amino group of lysine residue in the mycobactin core by MbtK (By similarity). Sequence Mass (Da): 41370 Sequenc...
O43462
MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSF...
Cofactor: Binds 1 zinc ion per subunit. Function: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 . Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SR...
O42954
MDINPPPSTAPSSPRRSIQRISDAKNKALTFNRRRLGLIKKAHELSVLCDAKVVVMIFDSKNACHVYSSEEPEEQRDALLQKFLNKDFVTVDPLRNINPNIPSDESLHNWRPKDKRIASVTTYSAQPSNNCSSATDSENDFQSFTIKSSTTYHTTPTTASENKKIESITIPDHASVYNDLPLSPTVKHSFVSPVSGDYSDSPLEPSSSSSFSVPPESLNPTLSFQHNDVPQTDNFIPFLTPKRQAYGQSSSRADRSSVRRSQSFKNRRNGKPRISRLHTSHASIDGLTDFIQSPSSGYLDPSSTPITPLDSAINQITPPF...
Function: Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15. PTM: Phosphorylated. Occurs periodically during mitosis. Sequence Mass (Da): 50907 Sequence Length: 457 Subcellular Location: Nucleus
P04298
MDANVVSSSTIATYIDALAKNASELEQRSTAYEINNELELVFIKPPLITLTNVVNISTIQESFIRFTVTNKEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIVWEKKSLVTENRLHKECLLRLSTEERHIFLDYKKYGSSIRLELVNLIQAKTKNFTIDFKLKYFLGSGAQSKSSLLHAINHPKSRPNTSLEIEFTPRDNETVPYDELIKELTTLSRHIFMASPENVILSPPINAPIKTFMLPKQDIVGLDLENLYAVTKTDGIPITIRVTSNGLYCYFTHLGYIIRYPVKRIIDSEVVVFGEAVKDKNWTVYLIKLIEP...
Function: Catalytic subunit of the mRNA capping enzyme which catalyzes three enzymatic reactions: the 5' triphosphate end of the pre-mRNA is hydrolyzed to a diphosphate by RNA 5' triphosphatase; the diphosphate RNA end is capped with GMP by RNA guanylyltransferase and the GpppN cap is methylated by RNA (guanine-N7) met...
Q9LHQ7
MKRGFSDSPSSSAPPPSSRFKSNPEGDSQFLEDETTKNFARKVADHYSRRTNQTLEEREASPIIHLKKLNNWIKSVLIQLYARPDDAVLDLACGKGGDLIKWDKARIGYYVGIDIAEGSIEDCRTRYNGDADHHQRRKKFSFPSRLLCGDCFEVELDKILEEDAPFDICSCQFAMHYSWTTEARARRALANVSALLRPGGVFIGTMPDANVIIKKLREAEGLEIGNSVYWIRFGEEYSQKKFKSSSPFGIEYVFHLEDAVDCPEWIVPFNVFKSLAEEYDLELVFVKNSHEFVHEYMKKPEFVELMRRLGALGDGSNDQS...
Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-tr...
Q6Z9U7
MNKRPRDEPSSSFASAPKRQYGAGGGGYGGHGYSEERSSARRVADHYSARSNQTLEERENSPIIHLKKLNNWIKSVLIQLYAHPGDCVLDLACGKGGDLIKWDKAKVGYYVGVDIAEGSIKDCMTRYNGDTDQQRRKKFSFPARLICADCYEARLDEHLYEDAPFDICSCQFALHYSWSTEARARQALANVSALLRPGGVFIGTMPDANVIIKRLRETDGMEFGNGVYWISFGEEYAEKKFPASRPFGIKYKFHLEDAVDCPEWVVPFHLFKLLAEEYDLELVLTKNFHEFVHEYLQKPEFAELMRRLGALGDGRQDQST...
Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-tr...
Q5HZ60
MSGFVVSKPEQSHHRLFDFAKTAIINIFAHPYATVCELYCGGAPETDKWEAAPIGHYIGIDTSSGISSVREAWESQRKNYDVEFFEADPSKDDFEIQLQKKLEQADLVSCWRHLQLCFETEESARRLLTNVACLLKPGGYFFGITPDSSTIWAKYQKNVEAYHNRSGAKPNVFPNYIRSESYMITFELEEEKFPLFGKRYQLKFSGDNASEDHCLVHFPSLIRLAREAGLEFVEIQSLTDFYDDNRAQFASLLMNAGPNFVDPRGKLLPRAFDLLGLYATFIFQKPDPDIEPPLTTPIPFESSNNHDERELPVITVITDA...
Function: mRNA capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-tr...
Q6K833
MAVTPHHRLYEFAKTALIKIFAFPYATVCDLYCDGGVDTDKWGDAQIGHYIGIDASASGVNDARELWESRKKLFTSEFIELDPSADDFEAQMQEKGIQADIVCCMQHLQLCFESEEHAQKLLNNVSSLLKPGGYFVGIIPDSSTIWTKYQKNVEASHNKGLKTVPNSIRSENYVITFEVEEEKFPFFGKKYQLKFANESMFENHCLVHFPSFMRLAREAGLEYVEIQNLTEFYDDNRTQFAPLLGGYGSSLVDPRGKLVARSFDILGLYSTFVFQKPDPDAMPPIVTPELHDPENDQEEEWLWTQQASMDDGRVSRTDIL...
Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-tr...
A1CT57
MENRSSSGTPRPSAGSPDAAKRPSETSPAAGRIPAGQNGSSGDKKRKVTEEGEASEKSEPPADRPMSKRKRMEERHQKLRKRGRTPPSAYSRRDAEAAPVPNRNRDDPANRSLSPLPHRSPTPEEQPRQRKRPGGGARMGLVDRETLRRRQEERERALVEEAMRTSQGRGVTDVVRQHYNAVPQRGREWRKTESKIKGLRSFNNWIKSTLIQKFSPDEEFLARLNDGRDWADDSGPPPAEEKRLLVVDLGCGKGGDLGKWQLAPQPVELYVGLDPAEVSIVQARERYNSMKSGRGNRGRRNPLFHGEFAPKDCFGEWLGD...
Function: Responsible for methylating the 5'-cap structure of mRNAs. Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine Sequence Mass (Da): 62163 Sequence Length: 551 ...
Q4WN42
MYDPARDSWEERDGDEARSCRGRLASDQPHAVFSPPEQIHGASGENNNTTDLQQHPDPSSKTTASAEVLYAESQPAQPTTQTPPSVSTRIQSPVDPAAQKASNPQSLTSTAQNQLNKSNTTMENTSGSATPKPRADPSDKPNRPVQVASPTDQNGSQGDKKRKLPAEENASEKSQPAPDRPVSKRKRMEERHQKLRKRGRTPPSAYSRRDAEETSSAADRNGPTYRSTSPLPPPRSPTPEDQPRQRKRPGGGARMGLVDRETLRRRQEERERAQVEEAMRASQSRGVADVVRQHYNAVPQRGREWRKTESKIKGLRSFNN...
Function: Responsible for methylating the 5'-cap structure of mRNAs. Catalytic Activity: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine Sequence Mass (Da): 74939 Sequence Length: 668 ...
Q9RPW2
SLSHGKYYALGSGPARAMATKVKDGAVEPVEELYKELEYRDSHDKTVLVIENDAVPPVEIVEKVAAACGVSPADLTIIVTPTSSLAGGVQVVGRVLEVAMHKAHALHFPLENIVDGTGSAPVCPPHPNFVKA
Function: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT. Catalytic Activity: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin Sequence Mass (Da): 13863 Sequence Length: 132 Pathway: One-carbon metabolism; formaldehyde degradation; formate fro...
P51616
MVSVNIEAKKIVDRMIEGADDLKISVDKLENGSTVIDCGVNVDGSIKAGELYTAVCLGGLADVGISIPGDLSERFALPSVKIKTDFPAISTLGAQKAGWSVSVGDFFALGSGPARALALKPAETYEEIGYQDEADIAVLTLEADKLPGEDVTDKIAEECDVSPENVYVLVAPTSSLVGSIQISGRVVENGTYKMLEALHFDVNKVKYAAGIAPIAPVDPDSLKAMGKTNDAVLFGGRTYYYIESEEGDDIKSLAENLPSSASEGYGKPFYDVFKEADYDFYKIDKGMFAPAEVVINDLRTGEVFRAGFVNEELLMKSFGL
Function: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+). Catalytic Activity: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin Sequence Mass (Da): 34230 Sequence Length: 320 Pathway: One-carbon metabolism; methanogenesis from C...
Q9RPD4
ICLGGLGKVTLAPAPGQTNWPFWLTVTSNDPVVACLASQYAGWSLSHEKFFALGSGPGRSLARKEPLFQELPYEDSASRATIVLEAGAPPPEPVVAKVAESCGVSPDKLAFIYAPTQSLAGSVQVVGRVLEVALHKAHELKFPLEHIVDGIATAPLSPPHPDFVTAMGRTNDAIIYSGRAHLFVRGSAEAAKALAEKLPSSNSRDYGRPFAEIFKAYKGEFYKIDPSLFSPAEAIVTAVETGETFRAGAIDEKLLDASFG
Function: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT. Catalytic Activity: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin Sequence Mass (Da): 27622 Sequence Length: 260 Pathway: One-carbon metabolism; formaldehyde degradation; formate fro...
P14200
MAKMSLSSYMLMLAFSLFSHGILLSASKSIRNVEDDIVFNTFRMGKAFQKEDTAERSVVAPSLEGYKNDESGFMKDDDDKTTKNTGSKQNLVTHGLPLSLAVKPYLALKGPAVFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
Function: MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates s...
Q7UPS1
MKSATPDDLPRTGVEPDLSRSASECFESLWNGAIGMRSLPLTIAGARVLDAGVTCSGSLEAGLGLARLCLGDLANVRYVPATADDLVGLSVTIQTDHPVLSCLGGQYAGWPVSVADYFAMASGPMRCLRGKEAMLEQLHLSRQATDDDFAVGVLESDTLPGEDVIEAMADECGVDPSRLCLAVAPSTSIAGSAQVVSRSVETALHKLHALEFDVTRVVSAHGDAPLPPPAKKGDTIGGIGRTNDAMLYGARVTLWVDAEDDAIDSVASKVPSQSSDDHGRPFAEIFKQYEYDFYQVDPMLFSPAVVTIHSLQSGRTWRHG...
Function: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT. Catalytic Activity: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin Sequence Mass (Da): 35408 Sequence Length: 333 Pathway: One-carbon metabolism; formaldehyde degradation; formate fro...
Q9RQ01
MTSQATSQATSPALTTPVDAAPQISLATCVAPLVEALIRDADALRLKVSRGPRDALIVDAGITAAGGLEAGRRIAEICLGGLGRVALVPTGRFSPWDTLASVSTSGPVLACLGSQYAGWSLAAGDFFALGSGPGRAIAAVETLYGELGYRDRGEKVVLVLETAVVPPAEVVDEIAARCAVAPSDITLILTPTSSLAGTVQIVARVLEVALHKAHALHFPLEHIADGVGSAPICPPSPDFLTAMGRTNDAVLYGGDVHLFVHGPAEAAKDLATRLPSLASRDYGRPFGEIFAGYDCDFYKVDPLLFSPARVTVTAIDHGES...
Function: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT. Catalytic Activity: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin Sequence Mass (Da): 34783 Sequence Length: 337 Pathway: One-carbon metabolism; formaldehyde degradation; formate fro...
P29458
MSSSQQSGRANELRTPGRANSSSREAVDSSPLFFPASSPGSTRLTTPRTTARTPLASSPLLFESSSPGPNIPQSSRSHLLSQRNDLFLDSSSQRTPRSTRRGDIHSSVQMSTPSRRREVDPQRPGVSTPSSLLFSGSDALTFSQAHPSSEVADDTVRVIWGTNVSIQESIASFRGFLRGFKKKYRPEYRNELMPPPDAEQLVYIEALRNMRIMGLEILNLDVQDLKHYPPTKKLYHQLYSYPQEIIPIMDQTIKDVMLDLLGTNPPEDVLNDIELKIYKIRPFNLEKCINMRDLNPGDIDKLISIKGLVLRCTPVIPDMK...
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits...
P30665
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEGNIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSSSSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPN...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits...
P55862
MSGFDDLGVYYSDSFGGEQQVGDDGQAKKSQLKKRFREFLRQYRIGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEETIQEIQVMLRSDANPANIRSLKSEQMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIAVRPGLEGYAMPRKCNTEQAGRPNCPLDPYFIIPDKCKCVDFQTLKLQESPDAVPHGELPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIRKSGKTSTKGRDRVGVGIRSSYIRVVGIQVDTEGTGRSAAGAITPQEE...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
O80786
MSGWDEGAVYYSDQPQFPEAGDAATISPHAVLTKFKEFIRNFEIEQNCFPYREALLDNPKRLVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNCKKTREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPWMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMGIYSIFQASSSSNSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEFKKFA...
Function: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Mass (Da): 81015 Sequence Len...
Q0V8B7
MSGFDDPGIFYSDSFGGDNAADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADYLYKQPAEHLQLLEEAAKEVADEVTRPRPAGDEVLQDIQVMLKSDASPSSIRSLKSDTMSHLVKIPGIVIAASGVRAKATRISIQCRSCHSTLTNIAMRPGLDGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTSNRGRDRVGVGIRSAYIRVLGIQVDTDGSGRTFAGAMTPQEEE...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
Q21902
MSNLDNPGIYYQERFFANDGVPDTGRELIAEYRQLITQFRNFIRDFSTGGFGMIYRDQLKRNYFSHEYRLEINLNHLKNFDEDIEMKLRKFPGKVLPALEEAAKIVADEITTPRPKGEEKLHDIQVTLTLDEYPTSLRQVKSAQVSQVVKISGIIVAAAQVRSKATKVTLQCRQCKHTIPDVSIKPGLEGFALPRTCAAPQQGQMQRCPIDPYIMLPDKCECVDYQTLKLQENPEDVPHGEMPRHLQLFTERYLTDKVVPGNRVTIVGVYSIKKLIQKKGGDKSLQGIRTPYLRVLGIHMETSGPGRTNFTTFTPEEERM...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
Q54CP4
MSGFDEGNVTVSGGGGKGGFKKNNGFVEDTSVRDLFKRFINEWKDQDNVFIYKEQLRQHYNLGWHYIEVSIDHLTDFNQELSGRFISSPNELMPSFEDAIKDIIKEMNYNKEQVDEDIQILFKSSANPEPIRYLRAGLISKLVKVQGIVISASRTQPKPSTMVVKCKNCQHTQTLHIRPGIVSSVLPQQCERGSNDAGKPCPNNPYVVLSDQSTFVNQQILKLQESPETIPTGEMPRHIILSLDKSLADKITPGTRIKVLGVLGIFEGGGKRREIAGGTIRTNYLRVLGITSDNAGRDSMHFTPSEEQSFKVFSRRQDLR...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
P33992
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEE...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
P49718
MSGFDDPGIFYSDSFGGDPGAEEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPRKCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEE...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and ar...
Q6KAJ4
MSGWDEGAVFYSDQAQFPRGGPGGDPSADLTRHSALRKFKEFLRGFTGPTGDFPYRESLVHNRDHVTVAIEDLDAFDAELSDKIRKSPADYLPLFETAASEVLASLRSKVAGETGEMEEPATGDVQIFLSSKENCLSMRSIGADYMSKLVKIAGITIAASRVKAKATHVTLLCKNCRSVKTVPCRPGLGGAIVPRSCDHVPQPGEEPCPLDPWIAVPDKSKYVDLQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVIGIYSVYQASANQKGAVGVKQPYIRVVGLEQSRDANSNGPSNFTLDEEMEFKEF...
Function: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Mass (Da): 80376 Sequence Len...
P41389
MAAATGWERSAVYYTPVLPGEQELDSNVSHEKNFIQFIEEFVIDNDFIYRTQLRDNLVVKQYMLNIDLRHLISYNEDLAHLLLSQPTDILPLFESAVTTVAKRLLYRSQENASTNIPTCQVTLRYDANILPIRNLTASHISKLVRVPGIIIGASTLSCRATALHLVCRNCRATRILQISGGFSGVQLPRVCEAPVLDGEKKDCPMDPFIIDHSKSTFIDQQVLKLQEAPDMVPVGELPRHILLNADRYLTNQITPGTRCVITGIFSIFQNKSVKASGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEEEEEEFLEISRTP...
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits...
P29496
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSG...
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits...
Q5FWY4
MELGGPAAAGDTDIAGQQLFKDELSDKCQKLFLEFLEECKGKDGSNLYVSAAEELIRPERNTLAVNFTDIEYYNQQLATTIQEEYYRVYPHLCRAVRSFARQMGNIPANKEFYIAFSDFPARQKIRELSSAKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSIVKDVEQQFRYTQPTICKNPVCANRRRFTLDTNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVESAMAGDRCDFTGTLIVVPDVSALAAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACYVGATNPRFGGKDLREE...
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits...
P15529
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPT...
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-ce...
O88174
MTAAPLMPDSTHPCRRRKSYTFFWCSLGVYAEALLFLLSHLSDACELPRPFEAMELKGTPKLFYAVGEKIEYKCKKGYLYLSPYLMIATCEPNHTWVPISDAGCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREG...
Function: May be involved in the fusion of the spermatozoa with the oocyte during fertilization. PTM: May be O-glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 40881 Sequence Length: 365 Subcellular Location: Cytoplasmic vesicle
O02839
MMAFCALRKALPCRPENPFSSRCFVEILWVSLALVFLLPMPSDACDEPPKFESMRPQFLNTTYRPGDRVEYECRPGFQPMVPALPTFSVCQDDNTWSPLQEACRRKACSNLPDPLNGQVSYPNGDMLFGSKAQFTCNTGFYIIGAETVYCQVSGNVMAWSEPSPLCEKILCKPPGEIPNGKYTNSHKDVFEYNEVVTYSCLSSTGPDEFSLVGESSLFCIGKDEWSSDPPECKVVKCPYPVVPNGEIVSGFGSKFYYKAEVVFKCNAGFTLHGRDTIVCGANSTWEPEMPQCIKDSKPTDPPATPGPSHPGPPSPSDASP...
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cell...
Q96AQ8
MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIET...
Function: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion . Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU . Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) . Location Topolog...
Q9CXD6
MDSGSVAAERPRRTPSRQRLPSSGCGVPARPGVSTLPGGRSWLRPRGRAARASPLLFLLLVPSPRLAATATATAPRRTLAERSRPGLVLPAAALGAGRNALGRLRLGARRVAALASSRRELSLSAKCHQLEHRKENLPLSVSRQLYFDTHALVCLLEANGFTIQQAEIIVSALVKITETNMNIIYKDMVSKMQQEIALQQVLSKIANVKKDMVILEKSEFSALRAENEKIKLELHQLKQQVMDEVTKVRTDTKLNFNLEKSRVKELYSLNEKKMLELRTEIVSLHAQQDRALTQTDRKIETEVAGLKTMLEAHKLDTIKY...
Function: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex). Location Topology: ...
Q0P4J6
MSRLQLRFLLRRALSGSGCPRYSMPGSGCPGCFLPRVTCFRDFNIITSTMQYNLDKRNIYTSVGKHYFFDTHAVVQLLEANGFSAEQSEIVVSALVKILNVNMNLIHKDMVTKEQQEISLQQVMSLIASVKKDMIILEKSEFSALRTQNEKVKIELQQLKKQLNDSIVKVRASNKLDFNLEKSRVKEMHADNERKLLELRTSIVELHSQQDRGLTQTKRKIDTEVSGVKTMQESHKLDTIKYLAGSVFTCLTIALGFYRLWI
Function: Key regulator of mitochondrial calcium uniporter (mcu) required for calcium entry into mitochondrion. Location Topology: Single-pass membrane protein Sequence Mass (Da): 30024 Sequence Length: 262 Subcellular Location: Mitochondrion inner membrane
Q21121
MRNGRCLVTPFVTAQRLANLRNTLWNRQQIAFSTTTASSSTSPIQESSSPLSIRFEYGLPLLDVPLPSRNEPCQFTMRPLSDTIGSLCEFLRQEDRGIDYVAVYGTNGVKLATCTSIEHLLQFGSFRLRLNDKFFDVTVPKTGTMPYDSDKLRQLDDLRATVASLHAALCVDEYKLSREKKLLLQLENAETLLAPLHDAKRKIEQECEAHTDRVMWAGFAAMGVQTGLFARLTWWEYSWDIMEPVTYFATYSTVCATFGYYLYTQQSFEYPSARERVYTKQFYRRAQKQNFDIEKYNRLVTEVDELRNQLKRMRDPLFQH...
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria . Constitutes a pore-forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and ...
Q08BI9
MAAKVCRSVLLLSRSSGAVASSAYPAFGVSSQRHQGTKTEALSMSLGGHQTVRRAHGLRTGGRCALFCHPSATLTAQGWKGSPSWQVQRLLCSPAAEDVSVVYQNGLPVISVRLPSRRERCQFTLKPLSDTVGVFLQQLQAEDRGIDRVTIYSADGARIASSTGIDILLMDNFKLVINDTSYLVQPPRRDLLPHEDGERLNDVKILVQQLYTTLRIEEHQLNKERELIGRLEDLNSQLQPLEKVKEELSKKAERRTTWVLWGGMAYMATQFGILARLTWWEYSWDIMEPVTYFITYGTAMAMYAYFVLTRQEYLYPDARD...
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at hi...
Q54LT0
MNSFVIRNGFGLVRTFNTRLFTTSTQNLEGELKTILGQAKVSKLQEKLKLDPRSKITFNDFKGIAKEVGIEEKEINSVSNALAQSGSIIYLPNSLNENLKTSVFTKPAHIYQSLEHILDIENKGVGLNKLIESKKSEINSLRQKIQPLEEKKQVIDRKAHRRATAIIWTGLGYCFAQAAILARLTWWDLSWDIIEPVSYFLTFGSVLIGYTYFTMTKTEFTYEALNHRLFSKRQDKLFKRNNFPKEDYENLVQAIDKKEKELKELELATKYDHTH
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria . Constitutes a pore-forming and calcium-conducting subunit . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of c...