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A0A2T9Z108
MEFETIVVPIIVIILVYIFILIIGPLNTFRANPLVQIFFVALYSAGLYIFVVDSLQVLEEAEVNNFYIAVIWLQVFTNLYFYLYCCVSDPGKITKSNIKNALEIFNYDRIIFFPSECKTCKLPKPARSKHCSMCNRCVAMYDHHCIWFNNCMGLQNYRYFLFFLASLLFLLITASSFFLYSVFKINYMNVLSKFQSRFITDKSFSIMKEIIATTLFASPYTSSLALFLLFLVPIIAFFLVYQTRLWLIGKTSNESEKWADIEDAIHDKIGILEIIEPQNQDSDDRPKILVENISMIKNMYNYGWKKNLELLVWPPYL
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 317 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 37071 Location Topology: Multi-pass membrane protein
A0A024TM56
MVNPLTRCMEDYCLPPYATFHTDDIVPAVRTALAEYALDLNALEDDLMDAGESNLCWESVMDRLEIIDDPLRRISMFLEHLRSVVDSPDLRAADAEIQPEILAMNNRRDQSDVVFQAMQRLRSRADFNTAFTTEQQRILTRKVLHATLNGAALGPCVKERFNEISVRLETLKMKFSENLMDAMNAFSRIVHDKHELQGLSDATLAHLAQNAVADGHKEATAATGPWKLSLEYPVYMPVMKQCSHRHTREILFRAFVTTASTPPFDNSPVVQEMLELRQARAQLLGFQTYAELSLQDKMAPSVEVVEDMLNDLRDKCLPLS...
Cofactor: Binds 1 zinc ion. EC: 3.4.24.70 Catalytic Activity: Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5). Sequence Length: 541 ...
T2MFJ3
MFSSIYDFYKRHRKKIIFTGIFVGSTYAITKLVSWKFNEWAELKVKEMEQEAKKQYLFESNQRTCTATFLSFLPDVQEVITSKTNLDQFLEILKLNPANKIEIWENIKILSMAQMIASVLSNILLLVLLKVQLNIIGGYMFVTMMYDKEMDVSDIQKRYLSNVKVFIEQRLPLLVDDVILSVKEIIGNVSLKEKISFLKLQSLTENVIEKLKSNHLKKSVNFSHPFSWYLINNETSNTEERYRRLMFQTNETLSGDSCALVLEDCISSGLQSILNNLKDVFFGYEEDPEAITSIESCAHTSFFKEIELPMAKITPLLNQQ...
Function: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. Subcellular Location: Peroxisome membrane Sequence Length: 358 Sequence Ma...
A0A7R9Q7K4
YYKLPNFIGILCVFGICFCALLYIKGLLLPSKGLYNRTKNPIFDYYWGIELYPHITPIISLKVWIICRFGLILWQYIVLLCWKANYETLPDGSINYSLTATTLLQTIYLMKFYYWEDGYMNTIDTSVDRFGYYVCWGCIAFVPGFYPITSVYLVDNTPYNEFGIKSLIAVLTVGLLVICLNYWADQQKLHFRATNGKCVIWGKPAKLIRAEYIDDFGKRKRSILLTSGFWGITRHMNYTFELLSTFLWCLPALYASPVPYLYLIFLTVLLIHRSVRDDNKCALKYGQYWQQYKHQVKYQMIPYVY
Pathway: Steroid biosynthesis; cholesterol biosynthesis. Subcellular Location: Membrane Sequence Length: 305 Sequence Mass (Da): 35911 Location Topology: Multi-pass membrane protein
A0A7R9L0G5
MNKLVKKSLPLVCVVTQLMAMLLFAFSFFDVEETLFSPGSAANTGHTIGPRSAVDLIRSDVHYKQIDDYCRPRLTTTTAKPMFNKLVLVVIDALRHDFIPSIDRPPKSVQSGDRRHRHRRASGDSGGHRMPFTESIMQTNGVGLVSISATPTVTMPRIKAMISGTLPSFMDFILNLSAYRFNGENIVENAFKANKKTVFFGDDTWIQLLPKEVFAKYNGTSSFFATDYTEVDTNVTYCVRRELKALHEWDVMITHYLGVDHIGHSHGGYHSKLMPKKLLEMDAVVESIYTRVSAPDVREPYLVVITGDHGMTDIGNHGGN...
Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 658 Sequence Mass (Da): 73719 Location Topology: Multi-pass membrane protein
N6TRR3
MALLIALGLLLSIILLYCVYSKWMFQHWARKGVPQLNPRLFFGDTLPLVRGQALRDFHLGLYQNFKSTGAKCVGIYNTHKPELVPIDINLLKDILVKDYSSFSSHGVFYHENNVLTSHVFNMEGQPWKDRRTKLTPIFTSGTRLYIPVIGVHLDPEYYPDPERFDPERFSPENKATRPDIAWMPFGEGPRQCLGMRFGMLQSKVALASLLHKFRFTLSKAMKPPFIADAGTLVYMFKQDVLLDATRVN
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 248 Sequence Mass (Da): 28439 Location Topology: Peripheral membrane protein
A0A072VFT5
MGTTVDDSCATQLIDGDGVFNLTGLDNFIKTSNMANTGLSYAVVAIMGPQSSGKSTLMNHLFHTSFREMDAFRGRSQTTKGIWIAKCTGIEPCTIAMDLEGTDGRERGEDDTAFEKQSALFALAVSDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTLLFVIRDKTKTPLENLEPILREDIQKIWDGVPKPQAHLHTPLSEFFNVEVTALSSYEDKEEKFKEEVAQLRQRFYHSIAPGGLAGDRRGVVPASAFSLSAQHIWKVIRENKDLDLPAHKVMVATVRCEEIAYEKLSQLRSDKGWLELEEAVQSG...
Function: Probable GTP-binding protein that may be involved in cell development. EC: 3.6.5.- Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 833 Sequence Mass (Da): 93010 Location Topology: Multi-pass membrane protein
A0A6L7ZXX0
MLVSEAWAQSGGGGSPDFSFLLMIVLLFVVMYFFMIRPQQRRAREHREMVAAVKRNDRIVTSGGLIGKITKAGEGPEIEMEIAPEVKVSIDRNSIQGVLNKKPGQKPSAANDSGERRSLLGGLFGGFGGRRN
Function: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-Y...
A0A938ENP5
MRIGVMGGTFDPPHDGHLALARAAAAQLGLDRVMLVPAAEPPHKPGGATMPAAQRMALVQAAVEGDPVLEASREEIDRPGPSYTADTLERIAGANPAADLWFILGADQLEGFPGWSRPERIVEIARLAVASRPGAGDPAMDVLAGTVAAGRVDVVDMPEIPISSTEVRARIARGEDVSALVPPAVAAMLRADTSS
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). EC: 2.7.7.18 Catalytic Activity: ATP + H(+) + nicotinate beta-D-ribonucleotide...
A0A966V5T1
MPSKKNDDLGKIGYEDAVSELEEILEELEGDDIDVDKLAERVKRASDLVKACRDRIAAAKLHVERVVAEVDDK
Function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Catalytic Activity: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. EC: 3.1.11.6 Subcellular...
Q08W44
MIRIDGSKGEGGGQVLRTSLALSLVTGTPFQLVNVRAKRAKPGLLRQHLTAVKAAAEVGAAEVEGAELGSRELTFKPRALSAGNYYFSVGTAGSATLVLQTVLPALMVASGPSTLMLEGGTHNPAAPPFDFLEKAYLPLVRRMGPRVDAVLERHGFFPAGGGKFRVNVLPAPLRPLVLLERGRVKRRQATALFSQIPFNVAQRELATVEQVLGWRPDEQRVEELKRSQGPGNALMLEVESEHVTEVFTGFGERGVRAEEVAGRAAEAAKRYLDAEVPVGENLCDQLLLLLALAKGGAFRTLPLDGHSQTQLETFAHFLEV...
Function: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-pho...
A0A7V6V2F2
MRRKTLQIPIGNILIGSEYPIIIQSMTNTLTSDIQSTVNQCIRLFDADAKLVRITARNLKEAECLKLIKNDLINMGYELPIAADIHFNPHLAKVAANYVEKIRINPGNFVNLFPNNKSYTNEQYKLEVDAIKNEIEKLLPILVANKVAVRIGVNKGSLSQRLIDKFGNTTEALVESAIENVKIFNKLNFNNIVISIKTSSVYETIAANRLLVSKLDKLGLYYPIHLGVTEAGIDKEGIIKSSVAIGNLLLDGIGDTIRVSLTGDPVKEISVAETIIKTYQKFLPLPPMPTYSYTLENAPKIFTINDLTTEHLDLNNLFID...
Cofactor: Binds 1 [4Fe-4S] cluster. Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. Function: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphat...
A0A7J3LYM8
MPYRILFLGTSAGMPTLNRNLPGILIEWDSDLILFDCGEGIQLRFIEYRIGMGRPLRVFISHMHGDHILGLPGLLQTFSLLDRKTPVEVYGPSRLGEYIHCLRDTIGLNTTYDLKIFKVEDNVYYDFGAYRILCRRVQHGGESYGYRFEEKDRPGLFYPDKAIALGIPKGPLWKKLQLGESIKLNDGRIIKPSDVLGPPRRGFKLAYTGDTVPCRAIEELAEGVDILIHEATFTEDLADKAMAERHSTAAQAAYIALRSSVKLLVLTHISARYVTSDILLDEARRIHPNVVVAEDGLTIEISRTEEDYEYRVIPRMHIDT
Cofactor: Binds 2 Zn(2+) ions. Function: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. EC: 3.1.26.11 Catalytic Activity: Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA pr...
A0A7R9M0L8
MTNEEIVRVIDIWIKESRELGSKYNWVQIFENKGAIMGCSNPHPHCQVWASNYLPNEARIKDQTQRQYKETHNKPLLMDYLTKELDKKERIVLQNENWVVLVPFWAVWPFETMILPKKQIIRLEDLSESEKHDLSDAMKRLLIKYDNLFEISFPYSMGF
Pathway: Carbohydrate metabolism; galactose metabolism. EC: 2.7.7.12 Catalytic Activity: alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose Sequence Length: 159 Sequence Mass (Da): 19033
A0A173R2N7
MKKVLLEIFDWVKTFVIIFIIVTLVHKYVFTPVKVDGPSMYPTLHHEDSVILWEFNYKPKAFDVIVFEYSPDVYYVKRVIGLPGQTVRYEDDQLYIDNQPIAEPFLEAGKEIISYVDDFTFDFTLQEICQFDPCDVIPEGYYLVLGDNRPHSKDSRHIGLISEDQILGKATWIQWPLSHFGKVE
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Cell membrane Sequence Length: 184 Sequence Mass (Da): 21529 Location Topology: Single-pass type II membrane protein
Q9C8T3
MVGVSPKIAPSMLSSDFANLAAEAKRMIDLGANWLHMDIMDGHFVSNLTIGAPVIESLRKHTNAYLDCHLMVTNPMDYVDQMAKAGASGFTFHVEVAQENWQELVKKIKAAGMRPGVALKPGTPVEQVYPLVEGTNPVEMVLVMTVEPGFGGQKFMPSMMDKVRALRNKYPTLDIEVDGGLGPSTIDAAAAAGANCIVAGSSVFGAPKPGDVISLLRASVEKAQPST
Cofactor: Binds 1 divalent metal cation per subunit. EC: 5.1.3.1 Catalytic Activity: D-ribulose 5-phosphate = D-xylulose 5-phosphate Sequence Length: 227 Sequence Mass (Da): 24111
C9LX83
MRRVFLEGEIADTMEVRGADAHHLQRVMRAKLGEKLLVADGAGGSAEAEVAGFADGRVQLRFVRRLSEAAESQAEIELFQCLPKGDRMDFIVQKTTELGVACIRPVLSQNVVVRYDEKKARARVERWQKIAAEAAKQCGRTRIPEVMPIVPLRAAMEGQGAAEYALRLFFYEMEERRELRTVLSDSEARRIFMLVGPEGGFDEAEAQLAVAHGFSAVTLGRRILRVDTAAIVALALVQYEKGDLGFAKSSIDDLGLQGQSV
Function: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. Catalytic Activity: S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine EC: 2.1.1.193 S...
A0A537F297
MQLRMLKGKIHRARVTGADINYEGSIEIDSSLLDAAGILPFEQVEIWSLTSGDRLTTYALPAPRGTGKIAVNGAAARKVQVGDEIIIAAFAIMSETEARNWKPLVVHVDEKNRLMPFPKITKPLARN
PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. Cofactor: Binds 1 pyruvoyl group covalently per subunit. Pathway: Cofactor...
J3JUZ7
MSGDEKPKDHPEHPRNLIPELCRQFYNLGWVTGTGGGISIKDGSKIYIAPSGVQKERIKPEDLFVQNIKGEDLELPPPAKKLKKSQCTPLFMCAYTMRNAGAVIHTHSKSAVLITMLFPGNEFKCTHLEMIKGIKNQKLGRNFRYDEELIVPIIENTPFEEDLADRLEQTIKDYPHTCAVLVRRHGVYVWGDTWQQTKCMSECYDYLFDVVVQFKQHGIDPSLTPDQYELEYQKNGKV
Cofactor: Binds 1 zinc ion per subunit. Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate...
A0A072TYF3
MLKDLSQKPLISILVLIFSTVIVLSTPPEDPIKCSNSQNTTCTITNSYGMFPDRTICQASQVFYPTSEQELVSMVASASREKIKVKVATRYSHSVPKLVCPEDSNGILISTKYLNKVVKIDVEEKTITLESGVTLKQIINEASKNGLALPYTPYWYGLTIGGMIGTGAHGSTLSGKGSAVHDYVVEIRIVRPSDSDDGYAKVEILNEQNNEDFNAAKVSLGVLGVISQVTLKLEPIFKRSITYVAKSDSDLGDQVVSFGHEHEFADISWYPSQHKAMYRVDDRVPINTSGNGLYDFIPFRPTPSIALAAIRITEDLDEFT...
Pathway: Cofactor biosynthesis; L-ascorbate biosynthesis. EC: 1.1.3.8 Catalytic Activity: L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate Sequence Length: 582 Sequence Mass (Da): 64705
A0A7M7L828
MIEMASIIVRRSFYASASQARSVGVLGIPMWRGQKKLGTDLAPAKIREDGRLISGVETVVGKPVRDFGDLDLSSYSQCDKNVTHYMAKTAQSIRKSVIHCLRECEQLITLGGDHSIAIGTVTGHADYVKEQGRDLAVIWMDAHADINTPMTTPSGSWHGMPVSFLMHEMMAHLPRIEDFKDWPSSISAHALVYVGLRDVDPQERWFLEKLQVPNFSMRELDALGIHKVTEIALDKVDPLGRKSLHVSFDIDCLDPLVAPSTGTPVPGGMSLREVAVLAEAIASTHSLTVFDLVEVNSLIGSYEDASKTIQSAALITRWMF...
Cofactor: Binds 2 manganese ions per subunit. Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. EC: 3.5.3.1 Catalytic Activity: H2O + L-arginine = L-ornithine + urea Sequence Length: 336 Sequence Mass (Da): 36761
A0A173RXA8
MGIILASQSPRRKELLELAGIEHRVVVSAVDEVMDADLDVAGQVQDLAIQKACAVADLFESETVIGADTIVVCDGKILGKPKNEEDAFNTLKNLSGRKHQVMTGVSIINKEKELLTSFVNITDVEFYYVTDEWILNYIKSGEPMDKAGSYGIQGKGFELVKSISGDYYSVMGLPIAQLKRTLTHLNLI
Function: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. Catalytic Activity: H2O + UTP = diphosphate + H(+) + UMP EC: 3.6.1.9 Subcellular Location: Cytoplasm Seque...
A0A350H6V9
MSNETNVEGKEKEVVEGVNMAKENIAIESTTKKKKKGKKKSWKYFLRKLLAKVAVTVVGVWLILTYVCGVYVNHNNSSYPMVKDGDLCITYKRSEVVKGDVVAYKKGDKVCFGRIIAKEGEEVDIRDGVVLVDGYNVVEDTVYETSAEESKIKYPYIVPQGKVFILNDFRKEVTDSRVLGGISEKDLCGELIFLIRRRGF
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Cell membrane Sequence Length: 200 Sequence Mass (Da): 22575 Location Topology: Single-pass type II membrane protein
A0A968KA93
IDEIHRLNRVVEEYLYPAMEDFSLEIMLDKGPSARSVQLPIKHFTLVGATTRAGLLTSPLRSRFGVVGRLDYYDVDSLQKIVKRSARILGVKIDQEGSFEIARRARGTPRVANRLLKRVRDFAEVAGNGGIDRAVASDSLARLDVDNLGLDEMDTRILEVIIHKFKGGPVGINTLAVAVGEEQDTIEEIYEPFLIQEGLLNRTPRGRVVTSNGYKHLNLKKSEKDQRELF
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an ...
V6LXD6
MSVVQTQPTASAVGSTPEYCVRALQLEDLHALAALLSQLSTVGELPLSAAEAFFADVSTSSFHQVQVIEDAKGSLVGAATLLVERKLLHGGSRVGHIEDVVVDQAIRGRGFGRQLVSVLVARAQELGCYKVILDCSDDNTGFYTKCGMERMGNEMAVYFQ
Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. EC: 2.3.1.4 Catalytic Activity: acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate Sequence Leng...
T2M3R3
MVSKVYVNGFVDCCFKKYILNQMKPNRRFFCLSSIVTNDFNEKDYKFHYLNSNVFQSKSTKDLIRSFVVLKTSSIGRFVDYSERMFLIGEKIIWAPLFRWLMKSTYYGNFAAGETVDEAKATADKLKTHNVLTMLCVPIESKKFSSNQEAEFEYEKNFNTVLRCIEETAAIESNGFAQLKITALCDKELLVNANKQLEKYQYSHNEDENWDIRTVVDLIKSCQYSKIKLSGLSDESNKKFVKLLSYLDKLAQHSAKHGVRLMVDAEQTYMQATLNYLVLVLQAKYNKERHIVYNTYQCYRKDTFKRLQADHNLAKNLGFL...
Function: Converts proline to delta-1-pyrroline-5-carboxylate. EC: 1.5.5.2 Catalytic Activity: a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+) Sequence Length: 481 Sequence Mass (Da): 55913
A0A0H1FGX0
MLKDKMIAKGAKYIQSIYQDPFIQGIIKGRLDHDVICHYLQADNIYLGKFADIYALCLAKSDNLRDKQFFLEQIDFTLNRELADGEGPHQALAAYTNRSYQDIIEKGVWYPSADHYIKHMYFHFYENGIAGALAAMSPCPWIYHQLAKKIIEENQFLNGNPFNNWITFYANDTVEELMENYFRMMDYYAQNLSKEKQADLVDAFVKSCQHERRFFQMAINQEKWED
Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis. Function: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. EC: 3.5.99.2 Catalytic Activity: 4-amino-5-aminomethyl-2-methylpyrimidine + H2O...
A0A7M7MCT0
MGLLTRLGILCLRTKQIPRLNSRGLLEEPRNSRATFIYARSTWATRTNDNVNISNQTTPKAQDIKTVSLERFVSVSPSWLQPYLRLMRIERPVGTWLTLLPSLWALTTAAPAGSLPDPRLAALFCTGALLMRGFGCTINDMWDRDIDRQVERTRQRPLAAGRLSRWDALWFAGGQAGLACLVLLHFNWNTVMLGLASVGLVVIYPVMKRFTYWPQAILAVVFNWGALLGFSAVQGADMSWTTALPMYAGAFSWTLIYDTIYAHQDKRDDLLVGMKSTALRFGARTPLWLGAFSTSMTTGLIVAGITENMGWPYYAAIAAS...
Pathway: Cofactor biosynthesis; ubiquinone biosynthesis. Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, ge...
A0A6P8YVC0
MDAGGLCDRLRHLHVRDDELAGQDAVNAVTNPDDIFQRWRCDARAAQLVMPDSAIITTCSRLGQASARTVCLRRMDEGRFVFLTDSRSKKCRELAENPKAVVTFLWAFVDRSGLRIAREVRIGGAVQPQPPSAYEDLYWSLIPNRRIRAYICEQGAAADWDRLKERHDQLLVEVEAGKRLPMPAHFVAYELFPCTMEFYEQVEEEEVCQSLQFIRAESGAWTLEESS
Pathway: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. Function: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). EC: 1.4.3.5 Sequence Length: 227 Sequence Mass (D...
C9LTK7
MKIIAGLGNPGAEYARTKHNVGFMLVDALAERLGVDAWREKFNALTAEGRIGAQKVLLVKPLTYMNESGRAVGPLLDWYKLAPEDLIVAHDDMDIAAGTIRLRRKGSAGGHNGIKSLLAHIGSEDFSRVRIGIGRPLPGWTVVKHVLAPFPADDAPKIQEAISYLLPAVECIVTDGIDMAMNRYNPRRKKAAKQEAQERESAEKSSAVPQAERQEGEA
Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Catalytic Activity: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+) EC: 3.1.1.29 Subcellular Location: Cytoplasm Sequence Length: 218 Sequence Mass (Da): 23745
A0A7R9KVR2
MAPNIQSPIEPEISDISDGIKTRRDFKVEIVWRNVAIMSGLHLAALYGLYLCFTSAHWQTMAFAVFLYVISGLGITAGAHRLWSHRAYKAKWPMRVILTIFNTVAFQNSIYEWSRDHRVHHKYSETDADPHNANRGFFFAHCGWLLCRKHPDVIEKGRNVSCEDLLQDPLVRFQRKFYLPLVLVFCFVLPSIIPNILWGESCFNAYFVCGLLRYCWTLNMTWLVNSAAHFWGRKPYDRHISPAENKVTIIGAIGEGFHNYHHTFPWDYATSELGRDYNLTTCFIDVCAKIGWAYDRKTVSPNMIRQRKERTGDVKEKGPY...
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Subcellular Location: Membrane Sequence Length: 541 Domain: The histidine box domains are involved in binding the catalytic metal ions. Sequence Mass (Da): 62028 Location Topology: Multi-pass membrane protein
T2M855
MSVLVETTLGDLVFDLYTEERPRSCMNFLKLCKIKYYNFCCFHSVRRNFIAQSGDPTETGRGGVSVYSFVYGDQAKYFELELKPRIKHRTKGTISFVNNGNDMHGSQFFITLGDGLDFLDGKHTVFGQLAEGFDVLEKLNEVICDDSHKPFQDVRITHTIVLEDPFDDPKDLPIPDKSPEPTKEVLESGRIAAGEKINDDDVSKEELLKKIEDKELAIGTKILETVGDIDDADLKPPENVLFVCKLNPVTNADDLKIIFSRFGKILSCEIIKDQKTGDSLCYGFVEFKEVEACEKAYFKMDNVLIDDRRIHVDFCQSVSK...
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) EC: 5.2.1.8 Subcellular Location: Nucleus Sequence Length: 687 Sequence Mass (D...
A7YD67
EMALAYRDRIQAHNQTEQFSPLMSLYLTDNTTADEVRKAKASGAVVAAKLYPAGATTNSDSGVTDVKKIYPVLQAMQEVDMLLLVHGEVTTHDVDIFDREKTFLDNVLAPIVQDFPDLKIVLEHITTSDAVVFVKNANENVAATITAHHLLYNRNHMLVGGIKPHFYCLPILKRNTHQLALISAATSGNKKFFLGTDSAPHAKGAKESACGCAGSYTAHAAVELYAEVFEQAGKLENLEAFASHNGPDFY
Cofactor: Binds 2 Zn(2+) ions per subunit. Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Function: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. EC: 3.5.2.3 Catalytic Activity: (S)-dihydroorotate + H2O = H(+) + N-car...
N6UJR2
MNLLQIVFCVLTATLIVYSSLINLLEPRLPQFLSRVFRYGKFAVPGKSVFAVEVPKAWFKHFYILAVVEYICFMGLLSLVYFAGMAVPPQINSILNTLCGPDRIARCGKHNVYLAACLLTTQVFRRFYDTQKVSVFGEQSKMNLSHYVVGHLHYLGTILAVLCEAPEFAYTSESHKQLNLITTSISDKISVLIFLCAWKHQHILGNLRKNEDGDVVSNGYKIPQGDWFKYLSCPPHQTAEIIMYSCVTWILWYNVSWFFIFTWVLVNQVETILLSHWWYKEKFDDFPKERKALIPFLY
Pathway: Protein modification; protein glycosylation. Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-gly...
A0A7M7JRE0
MGDGWALFVLSSSMFVGCYLSGLIPVSMKLSEDKINVVSILGAGLLVGTALTVIIPEGVSTLYLSRLEKAHTDHHQEVATEARHSGHHHEAHHFDDPHSLIGITLVIGFVFMLLVDQCSKRGKSSEELLPTGPNKTGAISIWKTRPATATLGLVVHAAADGIALGAAATTTRAEIEMIVFLAIMLHKAPAAFALVSFLLHEGLDRSTIKKHLLLFSAAAPILAITTYFGISQNTKESMASMNATGIAMLFSAGTFLYVATVHVLPELAASKGNVLGNKRRRCVSPTIQRRPSFLGKYLGRFYRSESYDWKLLSENSAFLS...
Catalytic Activity: Zn(2+)(in) = Zn(2+)(out) Subcellular Location: Golgi apparatus Sequence Length: 383 Sequence Mass (Da): 41458 Location Topology: Multi-pass membrane protein
C9LTV2
MDINGKDYLTIAFPKGKLFGLSKELFSRVGYTAEGLEEKSRKLIISNEEKKIRFIVAKTADVPTYVEYGAADIGVIGKDVLAEAEKDVYEVLDLGFGKCHLMMAVDKAQRRAKLADYAHTRVATKFPHIAEQFFTKKGMQMEYIKLNGSIELGPLVGLSESIVDIVETGTTLKENNLEEIAHIMDATARLIVNRVSYKLKFERIYRLVEDLRSALESGEAKS
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. Function: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosyn...
A0A8T4Z7E4
MVTEGFPFPTTILSEGKVRILVPRATIEGPSLKGPSSRRFPVFYNPGMALNRDLSVLALRVERRLLGREALACDAMAGCGAKGLRLAAEVEGTRILLNDINPMAVRLINYNVRLNALEERAIVRNEDARLLLLERAFREGTLDYVDVDPFGSPAVFVEAALCSLVDGGFLALTATDTAVLNGVHAEACIRKYWAKPLRCEYHHEVGARILLGYTARVAAMHGFGISPLLTERSSHYVRTIVSINRSSKSLRETMNSLGFLFHCHSCFHRHLEPYDHAHKRTGLVCSCGSKLSWAGPLWIGRLGDKAFLKSMLQESEKGAM...
Function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. EC: 2.1.1.216 Catalytic Activity: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine Sequence Length...
A0A7M7KLG9
MQTSSGQRPRNGGRTSDRPRGFGGGGVNRGEGGGRGENGGRDEVTYSRFEGTIGRGFRNEGAHSRAGGSGGCGGEKGDRRRLSPSSRQQGAPGEGRGPPRMKTLPIVDTGGENTTSAVNECVVCCREILVYAVGSCDHSVCYVCSTRLRVLCKTQECPVCRATVEEVYFVKENTPFGELKEKTFNLKQKQFSIFFQDDEVQLKYEELLRHKCKECERRALIAARSGERPSALEVFPTFDDLTDHVLKEHRRHFCALCVEHLNLFTFERQAYSKNDLRRHMIEGDLDDKSHKGHPRCDFCKEHFLDKDELYRHLKVEHFTC...
Pathway: Protein modification; protein ubiquitination. EC: 2.3.2.27 Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Sequence Length: 968 Sequence Mass (Da): 107019
T2M3E7
MRKKYVVFTFLLLFLAAICIYEWSTNLEEVIILPEKPVNSFNRFSLKSILLWNDLFGKENWGFPRSTNYDFKELECRVQNCFITTNRDLTLDADAVIFHISGKLNSRPKLKPVNQRWVFLMHEAPCLHNFKSLRQWNSLFNWTMTYRLDSDIPIPYVHTCKKRNSKVNLLEKDIMGKKKKLAAWMVSNCNSQSQRNQYMNELLKYIPVDIFGKCSALFGQNNKCEKNDEENCMNMISSQYKFYFSFENSFSVDYATEKFIKVLNTNAVPVVRGDANYTVLGPPNSFIDTKKFKSAKHLAEYLLRLDQNEVEYLEFLKWKE...
Pathway: Protein modification; protein glycosylation. EC: 2.4.1.- Subcellular Location: Golgi apparatus Sequence Length: 372 Sequence Mass (Da): 43844 Location Topology: Single-pass type II membrane protein
G7L858
MLVAFFICALMITNIIQVNANFSKSMYLTWGAQHASIVGEDLHLVLDKTSGSAARSKRSFLFGSIEMLIKLIPGNSAGIVTAYYLSSTGSQHDEIDFEFLGNSTGQPYTVNTNLFTQGKGSREQQFHLWFDPTADFHNYTIHWNPTEIVWYVDSMPIRVFRNYEHEGIAYPNKQGMRVYTSLWNADNWATRGGLVKTDWSKAPFKVGFHHFRARACKWNGAASINQCASNVKANWWTSSVYKHLSYGKIRQLNWVKKNFMTYDYCKDYKRFNGHIPHECFKTQF
PTM: Contains at least one intrachain disulfide bond essential for its enzymatic activity. Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construc...
A0A960GHH2
MIRVAVVGAAGRMGSTVCAAVDAADDMEVLAKVDLGDPLDLVDDCDVVVDFTAPDVVMETLRHCVPAGVHVVVGTSGFDTARLAQVEDLLQGHPDVGVLVAPNFSIGAVLMMRFAATAAPFFESVEVIEMHHPDKVDAPSGTAVRTAEMISRTREGRPSPDATTTALDGARGAQVEGVTVHSVRARGLVAHQEVLLGGVGETLTIRHDSLDRASFMPGVLLGVREVGTHPGLTVGLDSFLGLA
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. Function: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Catalytic Activity: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydro...
A0A832FZ07
MTCHIAYLIDDSIIVPDFESSRRLYSKSFYGTPIGVKKPKRADFNAPLKLSLIEALYLVEKGELKVVDMQGKALDIDELRRIALKSENEYIIYQIYKDLREKELIVRSGLKYGGAFTVYRIGPGLEHAPYIVHIYRRDENLDPIEIIRAGRVGHSVRKTFTLAFLARDGKPIYIMFKWVKL
Function: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a s...
A0A291E5P3
MPGSVSRLFFMCMLCTSILSAHALQAATGNELNEALQGCEDQYKKAGNYGDCSLMDYQAGYVILKTRTASDNQFLLLPMDNVTGIEDKGVLSRPYTHPVSSLFYSAWQSRGFVFDQLKQRGKKLAEKDIALTINPVNSRTQNHLHIHISCLAAKTQQSLSDLDIEKLGWGWESKPLKNKNDRDILYDIRKLSATAFLNENIFDLVHERYRSNMKYAEVTVVPARTRSDEFLLLVNPGSVSSPATAEELQDHSCTVAKSAH
Pathway: Lipid metabolism. Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) EC: 3.6.1.26 Subcellular Location: Membrane Sequence Length: 260 Sequence Mass (Da): 29094 Location Topology: Single-pass membrane protein
A0A968KAU8
MKVREKEDKKTKEKDTKQDGYQVTLEYIKSFLIALLLALLIKATIIEAYKIPTPSMEKTLLAGDFILGNKFIYGINIPFTDIRLPAIREPKRGDIVIFRPPHSPHENYVKRLIGMPGDTIKITRKRVYINGELYNDTAFTQHTSDYIMPRDRVIGPDPFIEAGIPNSGHRPWRPFRDNSYPIVVPEGKYFMMGDNRDNSLDSRMWGFVDRDQILGKALIIHWSWDIHDTSAPAVEFRNPLSIIQNIIYNLIHFPERVLWERLGTIPQ
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Membrane Sequence Length: 267 Sequence Mass (Da): 30991 Location Topology: Single-pass type II membrane protein
A0A7C4D8R2
MMVPRGHHIIGEVFADPEVLDDLEFIKEVFMEATEIAGLNVLDVKFHKFEPVGVSGIILISESHVSIHTWPEDGYAAIDIFTCGDVGKCWEAYRHIISRMRARRHMEIEIKRGLIDEEE
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme...
A0A7R9L7G4
MSAKVTLVSSSGCFGGKQQVWSHDSHELKCKMNFSVYIPPKVTDGVKVPVLFWLSGLTCTEQNFIIKSGFQKYAAEEGIIVVGPDTSPRNVNIEGEDDAYDFGSGAGFYVDATQDKWKQNYRMFSYITKELPKVIDDNFPVIKDCRSVFGHSMGGHGSLICALKNPGLYKSVSVFSPIANPMVGKWGQKCLSGYLGDNQKVWEEWDATVLVKKYKGPPLHLIVEQGADDPYLADELYVQNFVDSCASAHVAVDYRLHEGYDHSFYFISTFLAQHIKHHSRILYNTVWSHDSHELKCKMNFSVYIPPKVTDGVKVPVLFWL...
Function: Serine hydrolase involved in the detoxification of formaldehyde. Catalytic Activity: H2O + S-formylglutathione = formate + glutathione + H(+) EC: 3.1.2.12 Subcellular Location: Cytoplasm Sequence Length: 552 Sequence Mass (Da): 62173
A0A072UYZ3
MAGRFLGSSSASIDMIVTNTPSQELALTNLAFISASDLPKFAVPGHDNLYLASIGDSFVFSISYPSFTTHESIRGGHIALNSIQRRCARVSAAESVPVTRFVPPENFNLAVLQLELEFIKKAGNKNEQIDAIVLAKQLRKRFIKQVMTAGQKVLFEHQGNNYSFTVSQVTVEGQQRSSSIDRGMISEDTFIAFEASRDSGIKIINQRESTTSNIFKQKEFNLESLGIGGLGAEFADIFRRAFASRVFPPHVTSKLGIKHVKGMLLYGPPGTGKTLMARQIGKILNGKEPKIVNGPEVLSKFVGETEKNVRDLFADAEQDQ...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo p...
A0A6P8ZM77
MVTLFALVVLVTLWLARYAAGRVKVTSLLAAVPGPSYPLPLIGHLIYMFGPMDGILDRGIRLYRTYGPGPIKFWIGEWPSVQIMRPEDIEPVLNSQKEVEKPDLIYKPVRAFFGDGLITLNGDAWFKHRRALTPAFHFSVLERYAGIFTRRAAAFADLLLAEVPADKTVNIMKFHSAFVTETIMETAFGMPPASRASSVQNKEMSDLVRATEDAFGVIVHRIFHPWLLIDALFKLSHSGRVNQRAEAIITRHAKAVIAQKKLELQQRRAAGDDDDAPDADEDAGVRKKYTFLDMALGGKSDVLSDAEILEEVRTLIAVQQ...
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 516 Sequence Mass (Da): 57990 Location Topology: Peripheral membrane protein
A0A2E4AY97
MANFITLAVDGGAGTGKSTLSKLISSENKFMYVETGSLYRAITYLMLEMKISPIDVGSEISGKELEFTSKIIKNKYFLYVGGRDCSLLDLRTAQINKQVSDYAALPAVRSFLIEFQRSQVGVAKLNGFKGIVMEGRDIGTKILPDADLKIFLFADFETRMKRRKKDGELDEIRNRDLKDLQRKASPLQRAEDALSINTAIHNQTETYSIVNRELLRLK
Catalytic Activity: ATP + CMP = ADP + CDP EC: 2.7.4.25 Subcellular Location: Cytoplasm Sequence Length: 218 Sequence Mass (Da): 24554
A0A173YMP4
MGNYYQPEIETMPVEKLQALQSERLVEQVKYVYDHVEFYRNKMKEAGVEPEDIKGIEDLHKLPFVTKDDLRDQYPYGFLGVPLSECVRMQSTSGTTGRRVVAFYTQEDIDVWEDCCARAIMAAGGTKDDVCHVAYGYGLFTGGAGLHGGSHRVGCMTLPMSSGNTERQIQFMEDLGSTILCCTPSYAASLGESINEGGHRENIKLKAGIFGAEPWTEEMRHNIEESLGIKAYDIYGLTEISGPGVSFECEEQKGMHIQEDHFIPEIINPDTGEVLPEGEIGELVFTCITKKAYPLLRYRTRDLCYLTRKKCSCGRTHIRM...
Pathway: Aromatic compound metabolism; phenylacetate degradation. Function: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). EC: 6.2.1.30 Catalytic Activity: 2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA Sequence Length: 434 Sequence Mass (Da): 48825
A0A2E7VC73
MKRIFIALSFPSDIVEELAALQFGLRGAKWVPSQNFHVTLSFIGDVSIVVLDNIIEMLRDLRSFPFCIKLQGINHFSSAGRVRSVWVNVTDKTALSILQKKIKNCLLRNNVSQDKREFNPHVTLARLKNARPEDVAGFIQFNNLFKTRSFLIESFTLFESIKQKDSSVYSPIEEFQLVHCVQ
Function: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. EC: 3.1.4.58 Catalytic Activity: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) Sequence Length: 182 Sequence Mass (Da): 20861
N6T332
MTEHLHDVVLPDNITEELLTSQHIDFIKKYGEEQNKFEYGMTDYLRLSGMYWGLTALELMNAGVTDTQDAIVEYIVKCQDPDSGGISACIDHDPHILHTLSGIQILAMFDKLDAIDIEGVVKYVQKLQQFDGSFSGDKWGEVDTRFSFCAVMILSILNRISAIKVQKAVKFVKSCKNFDGGFGSRPLAESHAGLTYCCVGFLSITKRFDVLDIDNLAWWLCERQNPSGGFNGRPEKLPDVCYSWWVLATLAMLGKLTWIDGAKLQTFIFACQDQETGGFSDRPKDVPDPFHTLFAVAALSLLDYENIQKVNPTYCMPQHV...
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. EC: 2.5.1.60 Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-ger...
T2M6D1
MGSIISKFQKKKSTQETLEIMEKEIDKLEENQNRNRDLQKSIVLSFLIFSVILYVLAAVIFYLWYFPKKWLQRLLYLLPFIGFPVLIFFLKKLLHFIFVTRIARNARTLANLKKEKKRILENVMETETYKVAKDILQRFDPKRKLVEQDFSIAENKTPSKDSDNKMLTTSITTSQVTPVLRNKPPQVTSNNIVNSRNGPQLVSPGQQGPTPNKFLGQQGPSPYKIAAPILPQNRSAFDKIAEYFVGDGPSNRYALICKQCFSHNGMALAEEFEFISYKCCYCNTFNQARKQRSHAPKLSQHDSDQSDSDHSKDKLNINGI...
Function: Plays a role in determining ER morphology. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 352 Domain: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. Sequence Mass (Da): 40395 Location Topology: Multi-pass membrane protei...
N6TQL3
MLIVHSMIVIIVLSFTDGARILGIFPMAAVSHHTLYSKLMKGLAEAGHDVTVVSPYRLKELPKNGKYRDVVLEGFAAEYEDKLKSLNYFELREKSLIDRYFHFTALMLPTTNHTLHNANLKKLVESNETFDALILEQMFNDNMKVYGYIFNCPVILLSPFGPNSWVNPTVGNPQPPSYVPQMNQQDFSNDLSFFNRANNLYCFIVEYLIFKYYIFPQQERMMHAIYPDAPPLDDLYSNVSLVLLSSHTSIWSPVPLVPNMVEIGGFFIDPPKKLPPDLQEFMDKATEGVIYFSMGSNLRSKNIPLEKKQAFLNVFKKLKQ...
Catalytic Activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP EC: 2.4.1.17 Subcellular Location: Membrane Sequence Length: 519 Sequence Mass (Da): 59483 Location Topology: Single-pass membrane protein
A0A7C4CQ85
MVKKRVIAIARERMDILMRMALDMASENINDAEAYVKLAWRIAERYNIRGKPILRRYFRCSKCKSFVIPGRGCRIRILKNRGLGIICMKCGSLKIIPIFNKRDNSLHS
Cofactor: Binds 1 zinc ion per subunit. Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. EC: 3.1.26.5 Catalytic Activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. Subcellular Location: Cytoplasm Sequence Length:...
H8YHY2
MIERNPEKNWPACLEHNKPLGPLISMATPATARAFCRVESLADLQAALAWANAESLPYMVLGGGSNLLFVDDYPGLVIQPGFSQLALAPGAEGQYQLVGGAGVPWQQVVDFAVARNLWGLENLTRIPGSLGAAPIQNIGAYGVELDQVFDSLTALDVQRGEVVAFSREQCGFGYRQSVFKGDGKGRYIVLEVRLNLSAEPRPVLSYQGLEDLAGESALTPAKVAAQVAALRGQKLPDPAALPNSGSFFHNPLVSHAQADRLRARYPALVSYPQPDGRVKLAAGWLIEQAGFKGFAEQGVGVHRAQALVLVNPGRESGARV...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 347 Sequence Mass (Da): 37220
A0A2Y9I3K4
MTTEEIDALVHQEIISHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVAKRCRDEAVAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHGIGSYFHGHPEIWHHANDSDLLMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSGGVQILTKLPHEA
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-...
A0A7V6V3H0
MDKYIIGITGNIGSGKSTFARWFADYNFYVIDMDLYAKNLYFNYSFRRKATDILGFDPIYNDRLRTQDIADKIYSDENKFKQLTELFLEFLPPLVDNTIKNLNDKYIVIDGALLFEYSLDKFCNLTICIYAPLILRYKRIKKYRNKKISKKRFLQIDKHQLSPDIKCKMADICVKNEGNIEKLKNNFLKILSSIDI
Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) EC: 2.7.1.24 Subcellular Location: Cytoplasm Sequence Le...
A0A1B1UZ26
VDTRAYFTSATMIIAIPTGIKVFSWLATYHGSKLNLFNLNNSIMWSLGFIMMFTIGGLTGIMLSNSSIDIILHDTYYVVGHFHYVLSMGAVFAIFNSFVHWFPLFFSMNMNQKWLKIQFWFMFIGVNMTFFPQHFLGMMSMPRRYSDYPDAYYCWNLLSSLGAMISFNSMIFFIFIMMESFMSKRLTIFKFNQTSLEWIMNFPPYNHSFNEIPIIIKNNYKFLIF
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A355IKH3
MHDDNIGKVDHQAEVDALYMRRCLQLAASGRETSQPNPMVGAVVVKDGRIIGEGWHKRVGLPHAEPMAIGAVKNQECLGQSTLYVNLEPCSHYGKTPPCVDLIISKGIPRVVIGTPDLFPLVSGRGIEKLRGAGVEVVVGVEADACRELNRHFFTFHALKRPYVTLKWAMTADGFLDYQREAGDGRVQLHISTPYTRLLTHKSRAEHAVILVGRKTALLDNPNLTVRDWYGPHPIRAVIDRQLSLPLTLNLFDGSVKTLVFTEVERQDREGVSYIRLDFSQPVIEQLLQALYERNLQTLLVEGGSTLHNAFLSSGCWDEI...
Cofactor: Binds 1 zinc ion. Pathway: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4. Function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate. Catalytic Activity: 2,5-diamino...
A0A072TRD5
MGPISDFPLMFIPPAMPSSPSSPELVHSEPNPNPIPEPEPNPESNTSHNAPSSPPQTTTNKPPPTAAEIAARYILQSPPLSFAPKPLSTSEVTAAFGVIDDLPSLTDEEQKPLSSILTTSSGDQFSGTSWWSNQLETGISALADLADLANPSDDDFGYQGYSIHTNLASYNSRKPFEIDNGGWSPVDYGYNFNNFFATASSPRSPSLKSVGAGITNMGNTCFMSAILQCFTHTVQMFLGLRYCTHASSCDVEGFCVICAFRDHLDDALERSRSPIVPRELVKNLNYFSAGFVIGNQEDAHEFMQYALNKLKRGFPVGEEN...
Function: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. EC: 3.4.19.12 Catalytic Activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the ...
A0A7R9PX17
MVRLISMFRVVYRPLRMSSTTTHTNHTWKRLQYNRMKRFVAKFQWFHVPISLVFTFIAFQQFRRIKRREEQKRYEQNPNQILAKPIYTASDLEISMYKLLPLRTVSRIWGWINSIELPLIMRSPILRSYVRAFGCNLDEADVDDLRQYKNLGEFFRRSLKPGVRPIDTTNGIVSPADGTILYFGKANEGTVEQVKGITYSLSSFLGPXILYFGKANEGTVEQVKGITYSLSSFLGPQTWRSNGARNDNYEKSLLINSTGKQSSDLYHCVIYLAPGDYHRFHSPVEWKISFRRHFPGKLLSVRPTFVSWFPNLFNVNERVS...
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme...
A0A520KEY0
MEEILKEVLSRIKPKDEERNKVRQIFEEIKNRIEEKAKSLGINVRVELEGSVAKDTWISTDKDIDIFILFPHGTDKEKAKEIGLEIAKYGAGENWKIAYAEHPYIKKKIDEYEVDIVPGIEIKEGERPLTAVDRTPLHTKFIKSKMNEEMKDEVRLLKQFMKGIGVYGAELKIEGFSGYLCELLVLYYKNFKNVIKNASNWRPKTIIDYMNYYKDIPCEEIFDAPLIVIDPIDRRRNVAAAVSLQSYSIFVMASKFFLEKPSIEFFFPSKLNVNLNDIINEIKKREISLVMIKMKCPKIPSDILWGEIKKTINKFVKLIE...
Function: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition i...
C9LVK2
MRTQYFSKERLAKLVEVFPKATFDAEAEEPAFIVTAADFPAVLRALKEKEGFDRLGNLTAVDWKDHIEMVYHLYNMEENVKLEVKAALDSAAPVIESATSLYPGAEFEEREVYDLMGVEFLSHPDLRRILMPDNYPAHPLRKDFVAPVPKMEGGKLVWLKKAPTS
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. EC: 7.1.1.- Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+) Sequence Length: 165 Sequence Mass (Da): 18757
A0A938EMP7
MSGVPMMPGMRPLFDAAAVRDADARAIAGGIPGEVLMETAGTLATREILAAFPPGSTATVLVGPGNNGGDGMVVARLLAEAGWDVRVQAPGAREPETPDGALMTARAAEAGIGVGDVDLHELRAGRRLVVDALLGTGTAGAPRGGVADAVEALVASGAAVVALDMPTGVDGDTGAAPAPAVRADLTITFAAEKVGLRVAPGRELAGRVVVADIGIPRDIQPDPAAWLATEGVIAAIPPRAAGDDKYAAGGVLAIAGAPGMSGAARLCTRAAMRAGAGIVAACVPHEVRVEVAIGAPEVMVTGVAGGAGMSLDALDAIMHQ...
Cofactor: Binds 1 potassium ion per subunit. Function: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that...
U3U5U7
MTQYYNCKNWVIWLSFCIALILQSISYPQEIHMFRPFWCLLILIYWVLIIPHQINVGSGFLLGVVIDLLEGSTLGIHALSFSIIAYVVAFKNNAFKTLALWQQALIVSLLSILEKIIVFSSEFLVVNLTFQPEMLLSSVINGILWPWIFLLLSKILHRYNLY
Function: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Subcellular Location: Cell inner membrane Sequence Length: 162 Sequence Mass (Da): 18768 Location Topology: Multi-pass membrane protein
V6LZD9
MTINKQQIISLKMSKMEKYAISAVSLLFVTTPNIMKLGNLHIFLNGQIVIGAKFQQAIYSMIGLLSPVLISIFSWAFLYNIQDASNIFIYRGACEAFITITCILCVFALFSVFITAFTDPGIIPGKELLESFTATLNEKIQSKSNTIRALPQTQKDLKISSNCQSQLPSESSMTLTILSSLHKPETPLKFQLKGYSFNSKYCSTCRFYRPLRATHASISNVCIQRYDHFCAWIGTDVALHNHGLFYLMLFIVFIQLSVMILINLTIIIYSIQAFVNIDVIPANLKGLGIFGMIMMLTLLGGAGYIIFSLCQLMQYHVNLL...
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 515 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 58439 Location Topology: Multi-pass membrane protein
Q08MQ6
MKAIVTGASGTIGSKLCAHLRCQGHDVVPWDRRQVPVNDYGAMERFVREVAPDVVFHLGAISQPSEWSDEGWGSNYAWASELAWLTRTLGVRFLFSSTSMVFSNSARGPFTRSSQPDASEGYGYAKRLAEERVLSQNPEARVVRLGWQIGEQPTGNNMVAFLEERMRQEGRVAASTQWFPSCVMLEDTVRLLPALAWAEPGVSMLDANERWSFHEIALALNALHGGRWRVEASEHPVLDQRMRDDRVAVPSLKERLPGLL
Pathway: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. Function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. EC: 1.1.1.133 Catalytic Activity: dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH Sequence Length: 260 Sequence Mass (Da): 29079
V6LUD3
MLDQIIQIYNIKQTQRTGWVHNSILNPETVGSHSFGVAFLAFQLCPKTLCRSKVVEMALMHDIQESMVGDITPNCGVSVEDKHEKELQAIKIISEKLNNADYVKFFTDYEDGITQEAKFVKNCDKLDMFIQALIYERQGHNLDQFYSQMRVTEFEEINMIITQIQNYRKGQQSNK
Function: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). EC: 3.1.3.89 Catalytic Activity: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyrib...
Q096B1
MSGLGAFKGRWFVVKIGGELAADRPKLAGSVGAAVRAFLDAGVRVAVIHGGGPQATELTNKLGLTPRMVAGRRVTDEATLEVVKMTLAGQVSVDVAAAFRLAGVPALCTTGVSAGLIDARKRPPKVITGAGPEPIDLGLVGDVTDVNTALFERLSEAGLVPVLGSLSGDAQGQVFNINADTVATRVAAKLRAAKLFLVSNVPGVLADKNDPSTRIPTLTPAEAQEKIALGVIQGGMIPKVEESLSMLEEGIEAIHIVGISPAHALLGEAQGAGSFGTAFLRNR
Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. Function: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate. Catalytic Activity: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate EC: 2.7.2.8 Subcellular Location: Cytoplasm...
A0A968F844
MFKTGIGIEMRPFVKGRRLILGGAKIDYPMGLEGNSDADVLCHAIIDALLGASNLGEMHELFPEDDIKYKDISGLRLLELVNLKLARISFAVENIDVILACSEIDLAPYKTYMLLNLSHALKIDSSMISLKQSNSFFHLVPQFGDGISAFAVCTLIDISEPAEEEEEAGSEEEYYE
Cofactor: Binds 1 divalent metal cation per subunit. Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP...
D2T034
MVGTALSLLIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVETGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGISSILGAINFITTAINMKPPALSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFSATQKST
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A3N5J2S7
MNERIIFHLDMDQFFAAVEMLHQPHLRGLPIAVGGNPSGRGVVVTASYEARRFGIRSGMPAAEALRLCPQIVFVHSSVSKYCDVSARIFKSLLEFTDRVEPVSVDEAYMDVTDTVWKDGGVQGLAMKIKRRIVESEGLTSTIGAGPNRLVAKIASGMNKPDGFTYIPADRVEDMFRDMPVGDLHGVGKATQRTLESFGIRTAGQLAEFPVDILKRRMGKFGEELVRIARGEGSDKVLVPDEQPEEKSMGHEHTFSQDISDPVLLLGRLHLLCEKVARRLRSARMAGCTVAVRIRYRGFETVLHGCKLKRFVQHEMDIYPV...
Cofactor: Binds 2 magnesium ions per subunit. Function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5'...
A0A7J3LWH5
MKLSDLGERKLIEIASSILEQDPDEILGLGVDDAAAKPICEDLYLVMHTDVVVESTDRLPGQSYRDLAWKAVTANISDIAAKGAKPYALLSAIGIPGIYSLEVFEELMAGLRDSSSTYGCYIVGGDLSSSRELFIALAILGLTHRDRIMGRRGAKPGDLVCITGEIGYTSLAYRVLFDEWCIDSDLRRIVLDRAYRPIARLKEGLALASTGVVSSCMDISDGLAISLNTLSEVNNVSIIIDHIPIPREVLEAVGRYSVDPIDLVLYGGGEEYELLFTVKPDGLKLVEDKLSSLKSSFTVIGRVSEGAGVYFTSGRRVEAR...
Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. Function: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. EC: 2.7.4.16 Catalytic Activity: ATP + thi...
A0A8W8MHS0
MYRQCSRFSAWQVHKHFNSKVLTPNHGLIAKTRCVSSKTNLKTEDDQGTAFPEQMTHIKYASKGLEKFPQKYKQVPLTLFIKKSKTLVMLDEISEKFTVTFPKSEDTLTVDIGPEDFAKLKNMLEKDKRDSSPAHNPESITECIWQEMKTDNNKLMQYYFRLSKIRLTGLVVLTAMAGYAMAPAAFDPIGFTMVTLGTGLTSASANAINQFFEVPFDSQMNRTKNRVLVRGYLSPLHAVTFAAVSGSVGLVVLALGANPLTAALGAFNLGLYTLVYTPMKRHTILNTWVGSVVGAVPPLMGWAACTGSLDPGAWIMAAIM...
Function: Converts protoheme IX and farnesyl diphosphate to heme O. Subcellular Location: Membrane Sequence Length: 455 Sequence Mass (Da): 50658 Location Topology: Multi-pass membrane protein
G7JEI3
MRPPYQRQISQPSSPVVSSSDLTTTTVVGYLKLITGTHATPTVVNTSDVDGHELQRGVVRKTLADRVIERFEEREKEKMMKEVRGDDGVGGDGGCGRWREERECCVGSKNIALENSTSISNDITGNDKEKFLDGLLVSGFDESSCISRSQSHFYHKPSPYLLSKLGKYEENHRKCGPNTRAFNEDMKIIAKYKENGTDCAAKIKQHANTLFCYQQMDKEGLFCEPFLNSTWLLPNDSPFWDANDVKTYQSTIEMEIMSNTLNEDLPSTMYVDLRYSGTSDERFFHCDHSQFLLSKIPLLFFDAGEYFIPSFCLL
Function: May be involved in cell wall biosynthesis. EC: 2.4.1.- Subcellular Location: Golgi apparatus Sequence Length: 314 Sequence Mass (Da): 35620 Location Topology: Single-pass type II membrane protein
A0A7R9LFC8
MVSKMKEMDIFGLGNPLLDITATVDDDFLHKYSLPKNSAILAEPQHEAMYEEVINKYDIEYSAGGATQNTMRYCQWIIGKNNQVTTFCGSVGNDYFGKIMEKKAKTDGVNVKYMTAPDKNTGTCAILLTDGGQNRAMCAYLGIVTSISLSLYSLFSSFVF
Cofactor: Binds 3 Mg(2+) ions per subunit. Pathway: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Function: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. EC: 2.7.1.20 Subcellular Location: Nucleus Catalytic Activity...
A0A7R9PTT2
MASEDYHISGVAAIICIAIGILIFVLLFIFAKRQIMRLSLKNRFVPHIPLARDAPKVLKQRIDSKLTVVRDITYEPNLLNYLHFESNESKEKNYEHIYRMKAIDSLATLEADIVEVTADCSLKRPPGQDLRYYLLRLVKDDGPLNNCDTKLINQFVDSYNSARHEPYPHFGLDQYNQFMTLLNTIRNCITTKTSPNRKCVQKGKDTTAQMAFNGKTQVSIRQNKVDFVVTDETSV
Function: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. Subcellular Location: Golgi apparatus Sequence Length: 235 Sequence Mass (Da): 26960 Location Topology: Single-pass membrane protein
A0A2D1CJ24
MSLRTLLSSSALIAMLGLGYGMWALISPGEERRRELVKNLPESNPLRMDETRKRNALVMQALKDAAETDENIASRMGRHR
Function: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-...
A0A173TXJ3
MGSSDVDFFIHSYYEFKLFGVTLSINTTMVTTVIVCLILLALILFARHEIMKDYDEPNVVQNVVEMIVEKMDAMVVSNMGIHAKKYLNYVEALMAFIFLSNISGLFGLRPPTADFGTTFGLALITFVMIEYAWIKTKGFGIIKDLLDPFPVFLPINIISEFATPVSMSLRLFGNVTAGTIMLGLWYALMPWFTKIGIPAFLHAYFDFFSGAIQTYVFGMLTMVFISNRYD
Function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Subcellular Location: Cell membrane Sequence Length: 230 Sequence Mass (Da): 25988 Location Topology: Multi-pass membrane protein
A0A1Q2CG59
MRTVVSSAEMRAAEQAVFARDPEADLMGKAAAAIARIADDVAPDGAVLVVAGAGNNGGDGLFAAALLAERRPVLFWRAFRDAHAAAVAAARAAGCREVDAVGAVAALADCSLVIDAVTGLGSRPGLPLALQTLVDACDAATVPVLSVDLPSGLDADSGALHPSFSAEHTVTFGSVKPCHVQQPAASRCGRVHIVDIGVTVPDTQLRVAEAADVARWWPRPDASSDKYSRGVVLVDTGSEQYQGAAVLSCSGALHAGAGMVRYTGRAASGLILSRFPSVVVGEGRAQAIVLGSGWGDSDGGEGRVALARMHSLPAVVDADA...
Cofactor: Binds 1 potassium ion per subunit. Function: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that...
A0A2E3Z9C5
MVAIAVPIRICCGIAVWERNNVIESLPAKNCWFLTGATAVGKTRIGLAMARRLHAEIISLDSMAIYQGMDIGTAKPTSDQQAEIPHHLIDIVPPDQEFSVACYLEAAHAKIEEIRRRGNEVLFVGGTPLYLKGLLRGLTPGPPANWKLREEIEAEVAKHGPQGLYRRLEQLDPVAASQIHPHDTRRLIRAVEVFRITGVPISHSQMQFEEEIPAEDCRVFALRRSREVQYERINERVDQMLERGLVEEVRSLIADIEELSRTARQAVGYQEVLEYLEHGDHEIMTAKIKTRTRRFAKRQETWFRSLSECRYFDLEDDCQV...
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). EC: 2.5.1.75 Catalytic Activity: adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylall...
A0A072TFS9
MEFSVRAAELTTLLESRITNFYTNFQVDEIGRVVSVGDGIPRVYGLNEIQAGELVEFASGVKGIALNLENENVGIVVFGSDTSIKEGDLVKRTGSIVDVPAGKAMLGRVVDALGVPIDGRGALSDHERRRVEVKAPGIIERKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQMNSRATSESETLYCVYVAIGQKRSTVAQLVQILSEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTG...
Catalytic Activity: 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O EC: 7.1.1.9 Subcellular Location: Membrane Sequence Length: 856 Sequence Mass (Da): 93237 Location Topology: Multi-pass membrane protein
A0A3A0DI42
MLRKQALAPNLMTVVNLLLGFLAIVSAANGDFVKSGWLIIVAAVCDVLDGKIARALHITSDFGVEFDSLADVVSFGVAPAFLIYSAQLHDLRLFGVLVCFLPLAAGAVRLARFNTTTTLLDKHHFIGMPIPAGAGLISSYVIFSHQLWESVQFPGLTIVLLLIGSTLMVSTIEFDALPRISFRRGRQNTVKLVLLALALTILAVSPSKTLFPLALGYILMQVGRAVLNSLRQDEDEDALPDISISKR
Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) EC: 2.7.8.8 Subcellular Location: Membrane Sequence Length: 247 Sequence Mass (Da): 26713 Location Topology: Multi-pass membrane protein
A0A0K2Y9K6
MFVDCVEITATSGKGGPGCVSFRREKFVMEGGPDGGDGGDGGGIVFKVDSNSDTLSAFRGKKHYKAQNGAPGGPKNCNGKKGQNLEIIVPPGTQVFNADTGELLCDLIESGAQTTLLKGGKGGLGNVRFKSASKQRPTYAQKGMAGVSLNLRLELKLIAHVGLVGFPNAGKSTLISVLSNARPKIAPYAFTTLIPNLGVVQAGQFKEFVMADIPGIISGASEGKGLGLDFLRHLERTKFLLFVLDTTYDIHQQYEELRHELAHFSQELSARDFGVVLNKMDIGQVYGFHAPKAQFVLPISAATTENTGQLLQLLAQALQL...
Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis ...
A0A2T9Y967
MSSEKVRSRKQQRYYMNSEFNSASQHGSDYDFNENEKYNLANPSNDLDYVPAYQKDHAVFQSTHLNQAKLADPTSGKRFRFTKKRLIVLGLVFLMAAYFRLWKLSHPSKVVFDEVHFGKHAGLYINRTFFLDVHPPLAKMMFAAAGKIFGYDGKFDFKTIGLDYTSTNVPYASMRFMPAFLGLAMVPITYITIAAFGGSEEACLLGSLLVTFENSFMTISRLILLDSILIFFTGLTVMFWALFLREEGHPFTKTWWVYLILTGVNMGNALSSKWVGLFLVGTIGVWTIKDLWFRITDYRVTLNEVNKHFWARVLGLIVTP...
Pathway: Protein modification; protein glycosylation. Function: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) EC: 2.4.1.109 Subcellular Locatio...
A0A7C4HE87
MLLYALAKMGAYHKPIRVSTTTIADKIGLSQQSVSRHLISLEEKGLIHRTISKEGSLIRISKAGGDFLRCIYIDLSAIFKGGPRSITLEGEVFTGLGEGAYYVAQEGYRRQFVEKLGFDPYPGTLNLKISDGKSMMLRATLDIYPGIEIKGFRNKNRTFGPVKCFLAIIGGRERGAVVIAERSHYSENVLEVIAPIYLREKLGLKDGDKVKVEIFI
Cofactor: Binds 1 Mg(2+) ion per subunit. Pathway: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1. Function: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). EC: 2.7.1.161 Catalytic Activity: CTP + riboflavin = CDP + FMN + H(...
A0A072UQB9
MAETRRTSSSSTTVLDSLGEEIVRIITPVSICMFLVVILVSILNTNDSPTISTIANIAYDETTSDSSWDKFLGALLNSLSFVVVVTFATFFLVLLFYFRCITFLKLYMAFSSFVVLGFLGGEISIFLIQHFSVPVDCITFLVVLCNFAVVGVCAVFMSKMAIFVTQGYLVVIGILVAYWFTMLPEWTTWAMLVAMALYDLAAVLLPVGPLRLLVELAMSRDEEIPALVYEARPVSNDCMDPRIIEARRRLWRERRIESAILITESGNSVLGSGGLNVEQSSHSNSDANTVLSTNLNENLTPENGSNLNSSSTYGTRNLVR...
Function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. EC: 3.4.23.- Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 458 Domain: The PAL motif is required for normal active s...
A0A2I5HKZ3
MDTSIITDLLIRIALAGLLGGLIGIERQLRAKEAGLRTHVLVGIGSAMFMIVSKYGFEDIIRQNHVDLDPSRIAAQVVSGMGFLGAGTIIIQKQIVKGLTTAAGMWVTAAIGLVIGSGLYEIGIYGAFLTLIVLEVFRQLSNRLLNHHCILQMKISPDCLSMVFSVLQKRRIRFSFRSLKESASEDKAWELFLILTLRPKESVNNIAPALLCIEGVKSVNIR
Function: Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase. Subcellular Location: Cell inner membrane Sequence Length: 222 Sequence Mass (Da): 24333 Location Topology: Multi-pass membrane protein
E2RZC6
MKSIIIYINFYFCLSLSSLFFYKDISENSQLSFQESSSFFNNNLVFFHDNIMFYMLIILVIVGWILFSIIINKNYNKFLLENNFIEIIWTLIPAVILIIIAIPSLSLLYLIDENIEPSLTIKIIGHQWYWSYEYSNFFSNIEFDSYMISTNDLNKGDFRLLETDNDLVLPVNTKIKLIVSSADVIHCWTVPSLGIKIDAIP
Cofactor: Binds a copper A center. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreducta...
A0A7R9LIT0
MPSNKTIETKNAIADQMDDTIDNKSDHLVTNKCLNDEELCQTDDQLMDSARLVVVDSGCDDTSGQTMTIDGQLVSEGHESAAKGETPEPMPYCSGGGAAKEPVLTYQLKWINWGSVKTPIITQNLNGPCPLLAIINVLILKRKIQLPSMMDVITDDQLMEYLGDCIISSVPKNIPEGVQLNYEQNFMDAMQILPKLPKGLDVN
Function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. EC: 3.4.19.12 Catalytic Activity: Thiol-dependent hydrolysis of ester, thio...
A0A355G8T5
MLRLSLLVLSLIVLCCVGCSGEVPTASDPEVPQAAEAGGKDTPSGADDYQVLLETTKGNIKLEVHPEWSPRGAERFKELVKNGFYNDTAFFRVIEGFMAQTGINGDPELHAKWRDNNIMDDPVVESNKRGYVSFAKTGMPNSRSTQFFINFGDNSNLDGMGFSPFAKVVEGMDVVDSLYNGYGEGAPQGRGPYQGKIVDEGNAYLKKEFPMLDYIKKATIVGEQPAETSEKAESKPETDNPGSEKPAAKEEEKTDAPAAEKKEDAAAKPETEKPAPATKE
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. EC: 5.2.1.8 Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Length: 280 Sequence Mass (Da): 30393
A0A072VCD2
MAFNQYFEEGMNQIDSLEEKSSQEMWKCASAEAISGSSGFDCNICLECVQDPVVTLCGHLYCWPCIYKWLNFHAENQEKQKEEPQCPVCKSEISKSSLVPLYGRGQTTPPSKGNDHQIGSVIPPRPLGPSWMTNLPRSLDAANVSQHNSRTYHPHYLNHSQRYASPMLNTGGSLPNPLDTSYGVFGEMIYARIFGNQVTNIYTYPNSYNLTGISNPRIRRHLMRADKSLGRICFFLLCCTVLCLLLF
Pathway: Protein modification; protein ubiquitination. Function: E3 ubiquitin-protein ligase. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellul...
A0A7R9KUZ5
MSSESDNTTKYLIQSLMWRQCVSEDNLKRLVTKCKRGEEAATEASNELVAEVVTRVNRQMRAYNISVSRGPNESDGTIYYALINTADNDITRMANSWSQKELLYFRKLMAAIIENKNSCIASTKMLNIGREDDIKFSLPVSETLTNKWVEQKWFEDVSDGKIAIGIRTLLEMSVYIRERFEVQDCFRCKILCIRGLNCMSCDTKLHYHCSDVQFIPDNKCPNCAKQFASTTTQNTNQSDSDSVANDSTQGVNGSAHNHRIDDSTDEETVEDLNEAIVGDSDEEPIQRRRSGRSKRSRLS
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Nucleus Sequence Length: 299 Sequence Mass (Da): 33974
A0A7R9Q094
MRHKYELIIASNDRPVVHSLHNKNLTFYVFLLLSLIVISFVIYLCNYYDIKHTTHQPFLHRYGPLVRYKSQYFVNPKLWNTERDDNSDDVPNEVISRSDMFDMTADDVMVFLQIHNTGGNVFLNHIINDLIVDNPCNCESNRRKRCQCLRPNRHNSQWLFSRLTVGTKCGIHPDFNELIHCCDRVLDELEGDSVKRRYFYITLLRDPITRFISEYNHFRGQEANGKASRHWCGGREVMQMPECDFRADVTIDEFMDCEDNLAINRQTRMLSDSALVGCYNRSYMPSEERHIVQLRSAENNLHKMAFFGLNEFPRISQHLF...
Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Catalytic Activity: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[...
G7KI20
MLSELLTNWTIYANKCEAFTSLLVGLDLAVRLLPLVDNSPTIGGFLAEVFLGLVLFHSTMTKKQRNL
EC: 3.4.21.- Subcellular Location: Membrane Sequence Length: 67 Sequence Mass (Da): 7439 Location Topology: Multi-pass membrane protein
W2MAC6
MRIAFVLLFVSAIVLVDSADALFPTAVRSERVLQGAQSGGMRSLRVHNEERGLPFFGGKSSNTKVSTTWLRDTTVYDDILTNAGFTTAFGIWKQNKYSEGKITRAMNKLGRTQDEIDRVLAGYRKFKNVKVR
Function: Effector that suppresses plant defense responses during the early stages of pathogen infection. Subcellular Location: Secreted Sequence Length: 132 Domain: The RxLR-dEER motif is required for the delivery of the effector to the host cell cytoplasm. Sequence Mass (Da): 14806
A0A832D1W3
MGKEATIWEHLEELLIRLRKALLVFAIATLIVPFIPVSLSSYKPLIYVVPQFILDRVAPDTIEVFGHVIEIKLAQASPFGGLKILLYSAILIGFIVSSPYIAYQIYAFIEPALYPHEKRWLLVGGFVAVILFLTGVIVALLAVLPFTYRIMFIISYSVVGDKLIAFADPVDILSSALLITVATGVAFEIPLVIFFLIYLGIIEIKSLTGTYMRYLLIVSAIIAALISPDPSGLGMILVLVPYYILIVIAVIIANILKSRRK
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Subcellular Location: Cell membrane Sequence Length: 261 Sequence Mass (Da): 28838 Location Topology: Multi-pass membrane protein...
A0A072UQB7
MTVLLLRRRLGRRNVAGRGNTRLMVTLLLVLAPVSSPVAATSAASAGDSGNADAPPKKHRGRPPGSGKKQLDALGAGGTGFTPHVILVESGEDITEKVMAFSQTGPRTVCILSAIGAISSVILRQPASGSIARYEVQLVNGQFEIVSLSGPMPLSENNGEQSRTSSLYVSVAGADGRVLGGAVAGELTAASTVQVIVGSFIVDRKKSSSSMVKSGPSSAPTSQMLNFGAPTTPTSPTSQGPSTESSEENDHNSNFSRGPGLYNNANQPVHNNMQQMYHHPLWAGQTHP
Function: Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs). Subcellular Location: Nucleus Sequence Length: 288 Domain: The PPC domain mediates interactions between AHL proteins. Sequence Mass (Da): 29893
A0A158R9V1
MAHTSIGPTYQFQIQLVLEEPHNLCVGSLSTGYLGALAEVPTRYIGGSGMREKCMRWGWETRGRSLPEGLKTTYTLQNCFSPVIRKNAINSRNDVFGRIAAWISQIPLIVGFSVLCLVFFHRDLHTIFYAVGMLANEAICKISKKIIRIPRPPTHPQSLVSSYGMPSNHATFMFFMMAYFSLFIKFRLSPRHYSTFARCFTVLFLFLISVITCYTRVYLEFHYVDQVCIGALVGSILGCLWFYVVQVILTPLFPRIVESKIGRTLMLQDFTHIPNIFTFEYNAVRASRPQ
Function: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. Catalytic Activity: a dolichyl diphosphate + H2O = a dolic...