ids
stringlengths
6
10
seqs
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16
1.02k
texts
stringlengths
117
4.4k
A0A1S3CLN5
MPSFRAFLNSPVGPKTTHFWGPVANFGFVAAGLADVKKPADMISGRMTAVLCVYSLLCMRFGYMVRPRNYLLMGCHAANESVQLYLLSRWAMGQRKTVDYSNE
Function: Mediates the uptake of pyruvate into mitochondria. Subcellular Location: Membrane Sequence Length: 103 Sequence Mass (Da): 11529 Location Topology: Multi-pass membrane protein
Q7ZW80
MQVTRSQISLFLCLLSCVSVIGARYTPDWTSLDSRPLPGWYDEVKFGIFVHWGVFSVPAFGSEWFWWYWKGAQNPDYVQFMIKNYPPGFSYADFAPNFHAQFFDPDAWADIFEASGAKYVVLTSKHHEGFTNWGSPTSWNWNSVDDGPHRDLVGDLGNAIRKKGLHYGLYHSLYEWFNPLYLSDKQSGFKTQEYVARKAMPELYDLVSRYKPDLIWSDGDWEAPDTYWNSTEFLAWLYNDSPVKDIVVVNDRWGNGCYCKHGGYYNCADKFNPQKLLNHKWEKCQSVDKISWGYRRNMKLSELMDLPELVQDLVYIVALG...
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. EC: 3.2.1.51 Catalytic Activity: a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose Sequence L...
A0A174EYE9
MRRLVTGKQMKEIDAYAIQTIGILSMVLMERAALAVADELMQEYQRRGRKPVLDARVLVFCGTGNNGADGAAIARILHLRGISVSIITVGDRSRWTGEMERQISIDEKLGIAIEDFGGYLPGRFDVAVDAMFGVGLSRELEGEFREAVVFLSGLKPEFTVAVDIPSGICSETGRILGAAVEADLTVTFGYEKVGTAIYPGKGYCGRVEVKDIGFPGYDGYSGTRFFTYDTSDLSRIPQRKQDSHKGTYGKVLIAAGSGGMCGAAYLSALAAYRTGAGLVKILTVETNVQILQTLLPEAIIASYPEGMEAEEPEAFRELVE...
Cofactor: Binds 1 potassium ion per subunit. Function: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that...
T1FMR9
MHLLILMAVLSMSPAAAAIISSNDADQVIGDLLKRVPLIDGHNDLAHQIFARKKNKINDLDLQNWTEVHTDIKRMKQGGVGAQIWAVYAGCSTQYRDAVRACLEHLDTIQRFVYKYPNELQMAYSSQEITETFKKGKISSLLGVEGGHCLDSSLSVLRMLYQLGTRYMTLTHNCDTPWVTNNLRDRNATNVAGLTQFGKDIIREMNRLGMIVDMSHVSKAAMVDVLATSVAPVIFSHSNSYKLAPHTRNVQDDVLLLLKKNKGLIMITFPSSFLDVSGEASISSVADHLEYIYKLIGIDHVGIGSDYDGTPSLPVGLEDV...
Catalytic Activity: an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid EC: 3.4.13.19 Subcellular Location: Membrane Sequence Length: 388 Sequence Mass (Da): 43428 Location Topology: Lipid-anchor
D8J2E9
MNFETWEPIYESIITDFGFDRREDERARDALARLVEPFDERRLAALGDATVAVAGAGPSLPDDLDRVAGADYVIAASTAADTLLAAGLDPDLMVTDVDKNPETARRLTRLGTPVAVHAHGDNLGLVERWVPRLGAESVLPTTQAAPRGPVRNFGGFTDGDRGAFLADHFGASELLFPGWDFEDPSVGATKARKLRWAERLLYWLETRRGERFGVLDGRRDGIEPVV
Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. Function: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydr...
A0A961A9M7
MDQKEYTQDLQALGSHTDYPTRPDISILECFPNPSPGSDYSIRFDCPEFTSMCPVTGQPDYGRFEFEYEPDELCLESKSLKLYLFSFRNEAAFWEELSNRIADDLFTLLKPHSLRLTGYMNPRGAISITTTVRRGRSASER
Pathway: tRNA modification; tRNA-queuosine biosynthesis. Function: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Catalytic Activity: 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH EC: 1.7.1.13 Subcellular Location...
A0A174MZ94
MGTEKRTEKRTEEQRRAEALALLKHILDIPSVNGKDREQETAVYLAEYLKRKGMETRVQLIDEHHGNVIGVLKGKTEETILFNGHLDTVPYGDINEWNTNPAVCTEQDGRLYARGASDMKSGLAVMAFVLGELAESGCVPQKTIVFAGTCDEERGGLGAKEIIKEYPDLFPELLLIGEPTSCQAGVAQKGCIWLKLSVSGKTSHGAEPWQGINALEQGFGLLADLREELKREEHPVLGRSTLQITMAEGGIAPNMTPDRAKFLADIRIVPPLNEKEVLNRLECLMQKRCEVYNGGLAFVPEITNYRMPAETGPENQWLHR...
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3. EC: 3.5.1.18 Catalytic Activity: H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate Sequence Length: 391 Sequence M...
D8J3R4
MTDDVDRRAFVERLLAFDTTDGNEAPAQEWFGCRLDELGFETYHWKPDSERLVTHPSFPDDPAEIETTGRPNVAGVIELGSGKGPTLLLNGHADVVPAEADQWSSDPFEPTWTDETLTARGAADMKAGLVASVFAARQLAEADLDGRVVVESVVGEEAGGIGAAESAQDPPYPVPDAAIIAEPTDLTPVIATEGTLMKRLTLTGRSAHAATPWHGEDVLDHFERVRNALADLEAERARGITHPLYEPFPRPVPIVAGTVHAGSWASSVPAHLESEFRIGVAPGETVDEVEQEVDRRIAAVVADSEWLTEHPPRFERFSVQ...
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3. EC: 3.5.1.18 Catalytic Activity: H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate Sequence Length: 411 Sequence M...
Q6P978
METVVHLMNDSVEFYKWSLTIADKRVEKWPMMSSPLPTLGISVLYLLFLWAGPLYMQNREPFQLRKTLIVYNFSMVLLNFYICKELLLGSRAAGYSYLCQPVNYSNDVNEVRIASALWWYYISKGVEFLDTVFFIMRKKFNQVSFLHVYHHCTMFILWWIGIKWVPGGQSFFGATINSGIHVLMYGYYGLAAFGPKIQKYLWWKKYLTIIQMIQFHVTIGHAAHSLYTGCPFPAWMQWALIGYAVTFIILFANFYYQTYRRQPRLKTAKSAVNGVSMSTNGTSKTAEVTENGKKQKKGKGKHD
Pathway: Lipid metabolism; fatty acid biosynthesis. Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fa...
A0A7W0F830
MKSSKKNFAKRISVDYSASLSGAIGAGGLSEGDLSKISASVKTAVKKLNARRASGEVGFAELPDDFKNASDIKKYADKLKGKCRNFAVLGIGGSALGPRALIDALAPSFYNMRDLAGRGGRPRIIIADNISPEFVKGIFDIAPVSDTVFNVITKSGTTGETLSIFSAALAMLKKKTGKSWKKHIVITTDPEKGYLREFARKNGIDSFSIPSNVGGRFSTLSSVGLLPAAAAGIDIKKLLKGAGDAGKFCFKEGLKDNPAALYAAMHYLFYKRGRRINVFMPYSENLATVSEWFAQLWAESLGKKKDRNGRDVFVGPTPVK...
Pathway: Carbohydrate biosynthesis; gluconeogenesis. Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate EC: 5.3.1.9 Subcellular Location: Cytoplasm Sequence Length: 483 Sequence Mass (Da): 52338
E7FC00
MKMEDVSLSSMDNSKMEGFAQEILSDLVEDACLGLCFEVHRAVKQGYFFLDDTDQESMKDFEIVDQPGVDIFGQVYNQWKNKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIASGNNTNKSESDQEDNDDVNDNDWSYGAEKKAKKRKSDKNPNSPRRSKSMKHKND
Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone ...
A0A913ZYR3
MTSLGLYVFLALAVCVAAAPQPKSVIEFGDMIRCLTDRNIISSWLDYDGYGCYCGFGGTGTPLDDTDRCCQAHDNCYDVVMKSGKCPYESHVYIINYDATIENCRQPDAVVTCKRAEDYGFLDSPWSECAAAMCECDRAGAECFAASHYDTSLKNWSQDYC
Cofactor: Binds 1 Ca(2+) ion per subunit. Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) EC: 3.1.1.4 Subcellular Location: Secreted Sequence Length: 161 Sequence Mass (Da): 17814
A0A133Z7L7
MVKTRVAVIGGGLSGLVAAYEISRCDPNADVVVYEASDAVGGKLKTVDLATGSVDVGAEAYLAFRADATRFFTSLGLKDRLRYPSDLKSGLWIGDGTLHSVPSRTVMGIPADSSSVKDLVDSETCARIDAEGEAYPIPWVEGEDALLGALVAERMGQQVVDHVVSPLLGGVYSSRAEDLGLRATIPELAAAMDDLSNHGESVTLTRAAAAVLQQRDEAREARVAGGAADEESSSASAKKPPVFASFVGGYRDLIDALVEQSSATIRVDSPVTAVLPAEAGSSHRFRVVSGSSTETEEFDAVVVATPADVAGQQLAEVAPV...
Pathway: Porphyrin-containing compound metabolism; protoheme biosynthesis. Function: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. Catalytic Activity: coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2 EC: 1.3.3.15 Subcellular...
A2RV27
MQTAGKCAVRLDLSHVFCPSSVWNCRAVNRVNGLVSCRRYSVIPPPRDEQEKAMLDRMLRVDHAGEYGANRIYAGQMAVLGRTQTGPLIQHMWDQEKIHLEKFNEILGEHRARPTLLLPLWNIAGFALGACTALLGKEGAMACTVAVEESISEHYNSQIRTLMEADPDRYTELLQLIKEFRDDEIEHHDTGLEHDAESVPGYMLLKTAIQAGCTAAIYISQRI
Cofactor: Binds 2 iron ions per subunit. Pathway: Cofactor biosynthesis; ubiquinone biosynthesis. Function: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Inv...
A0A2E4QTA4
MTKPVLLCILDGVGLASPGPGNAVTLADTPFIDKLFETRAHSALRTDGPFVGLPEGQMGNSEVGHMTIGSGRIIRQSLEQVRHDLANGTLEALPGYSAFKQKAKEKRAIHLIGLISSGGVHSHMDHIVGIAKSLSKLGKPVYIHGLTDGRDTDPQAAKEEIPAFVSQIADIPGVELVSLVGRYYGMDRDGRWERMEIAWKLWTQGIGEEAADYNAAIAKVHEAGKTDEFLPALNLMPGDRDAQIQSGDAVMVCNFRADRARQIVELLMQTQDSAKLEPVVNIDAIATLTEYKSDFPKPVDVLYPNREFTGLLGDVVAAAG...
Cofactor: Binds 2 manganese ions per subunit. Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. EC: 5.4.2.12 Catalytic Activity: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate Sequ...
A0A352ZCH1
MHSINTDELKKRFIVIEGIDGAGTTTQMNLLAGSLRALGLSCVTTAEPTTSPIGMLIRSVLSGKNEAAPSTVAHLFAADRNEHLYGKEGIAQKVEEGALVISDRYVLSSLAYQGVTCGPEIPWQLNSRFPAPGLTLLFEVDPEVCIKRIDTRSNKEIYETLEFQKRVHDMYAVMADRLEQQGWHIERINADGDIETVRQRIEAVVFAFLGVPSGGITGSASRLHS
Function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. EC: 2.7.4.9 Catalytic Activity: ATP + dTMP = ADP + dTDP Sequence Length: 225 Sequence Mass (Da): 24640
L1J3G7
MRRAWQRTVKAAMAWEGQGLHGGERARMVVHPAAGNAGILIQGIRASWESVVDTSLSVTLGQPPKNGLQRTLAAAGVWISRGGAQTLGHLLSGPTVSTVEHLMAALSGCGVDNARVEVSGGEVPIMDGSAKEFVSMLKDNVVELPEFERRWIVVEKEVIVDDGHGRMAMLSPPSHAERSRGSLRLHVEVNYDEKFEQGAGVTSEGEGAGGAGGWRGRWGGSRVFEFEREEFEGVASARTFCFHQDVEQMRRMGLARGGSLLNAVVFKGGEVMNEEGLRFPDEMVRHKALDALGDLSLGGRLVGRYQSVKAGHGINVQLLR...
Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer memb...
H1XTK1
MRPLFKSATLRLKMMLAVGGVVVVFMVFISIGIALHWRSMILQQLQQKAEAVTSAFGISVLDALIYSENENFQVEDLLESYMLGLKEKIPEIQYIVVTDTHNRVIAHTDPRMYNRLLTDELSGRLAKTTGLVSGIYRTPQFGWLIETALPLQVGGKRWGILRIAFEAESTRREIARLFYLLVGITLLLTLVVLAVLNYLIKHTVRSLMLLVQAMDSMELDSSAPLELPERADEIGALTRHFELLRQRLQNSQAQLLEAQKQIYHAEKLASIGRLASGVAHEINNPLNGIKHCVYAIEKEPQNQKQLKEYLALINEGLEHI...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 489 Sequence Mass (Da): 54935 Location Topology: Multi-pass membrane protein
X1WER9
MSGFNRSFTLLRAAMRHQLIPKANITAKPAKHALSAGEQVIALSVMFVTILGPSGWILSHLEDYKHRPGAAQE
Pathway: Energy metabolism; oxidative phosphorylation. Subcellular Location: Membrane Sequence Length: 73 Sequence Mass (Da): 7982 Location Topology: Single-pass membrane protein
T1EHZ7
VLFLFVVCNFMLSTFLDPGKYPKAHEVKDNNAPMYKNVEIEGTSVSLKWCRTCKMYRPPRTTHCNECNYCVEIFDHHCPWVNNCIGRRNYRYFLQFLWLLIMHMLFLFSLLVVFIWQHRHDLKASNIIIAFCILIVIGLLCWPITGLAMFHVMLVSRGRT
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 160 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 18952 Location Topology: Multi-pass membrane protein
B2MYU5
MTYWGQLGFQDACSPLMEQIIFFHDHAMFAIIMVLTMVMYMSMILMTNKFSCLNITESQKIETVWTIAPALILLFLALPSLRLLYLLDETNDPLITIKTMGHQWYWSYEYSDFLDIEFDSYMVPTNDLELGNFRLLETDHHLILPMKTNTRIIVSSADVIHSWTVPSLGVKVDAIPGRLNQLMLYPSRPGLYYGQCSEICGANHSFMPITLEIVNMDYFIKWLNLMNEQ
Cofactor: Binds a copper A center. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreducta...
A0A817XGQ2
MLTSLSIDHTLLKPDATLKQIDQLCTEAIECKFATVCIQPCHVKYVVDKYSVRVCTVIGFPLGTTTTETKLFECQQALNDGAQDIDMVINIGKVKDENFEYVQNEIEQLAKLVHSSGENNILKVIIETCLLNDNEKQKLCQIVGNAGADFIKTSTGFSTGGATLNDIKLLRQYSPKNVQVKASGGIRDSNFAKELIQAGATRLGTSSGVALMKDIPSTSNYYYGDNGTFSPPMDVTNQIQNGIIQHTSGNSNYSSGSGGDSPTSLSPVPMSSGGQFMGIGGNSNSSTSSTPTATTSGGMGSAAAAAAAAAAAASRYACVI...
Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. Catalytic Activity: 2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate EC: 4.1.2.4 Subcellular Location: Nucleus Sequence ...
Q6P2U2
MMFNKGRVSSAFLISWMYFVYISSGLETTIDPTAESITLSDIIGNATEWMMDFTDIESKFSFRTLEEPEDDLCYIVPGQPQSIKDCNFNTETKTFIVIHGWTVTGMFESWVPKLVTALYEREPSANVIVVDWLSRAQQHYPTSASYTKLVGKDVAKFVNWLQAEIDYPWEKLHLLGYSLGAHVAGIAGLLTKHKVNRITGMDPAGPTFEYADSLSTLSPDDANFVDVLHTNTRGSPDRSIGIQRPVGHIDIYPNGGTFQPGCDLQNTMLMVATTGLRNMDQIVKCSHERSIHLFIDSLVNQDHESMAFRCSSRDSFNKGM...
PTM: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. Function: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance f...
B0UXE0
MRKKNVESALLFLTGVVCLLIITNKNDSKEDDVNLKSKKTEEILHNQEDFSRTETLPPSTSYCQPNMSFYKLPEFSTLPDHIKDFLLYRHCKSFPMILDVPDKCGGAQNSADVFLLLVIKSSPENYDRREVLRKTWAEERLHKGVWIRRIFIIGTSSSGLGKRRMNRLLKLENNENKDILQWDFNDSFFNLTLKQILFLEWMDRRCPHARFLLNGDDDIFANTFNMIEYLQGQEDNDGSRHLFTGNIIQNVGPIRKRSSKYYIPVQIQESDIYPPYCGGGGFLLSGFTARTIYNMSHSVILLPIDDVYMGMCLKKAGIKP...
EC: 2.4.1.- Subcellular Location: Golgi apparatus membrane Sequence Length: 392 Sequence Mass (Da): 45555 Location Topology: Single-pass type II membrane protein
L1IIS5
MRSVAFAALIGSAAAFSPSMSLDVSRRQVVQTGAAAAAVAPFLQQVPAQAAMDKSGRAPVITIFDHRGCTAHANKEYTGAKANSQDDEMCVKVASAKIAVSEGDAARKLQEFISYQAKGIDGPYTGKGKK
Function: Light-harvesting photosynthetic tetrapyrrole chromophore-protein from the phycobiliprotein complex. Subcellular Location: Plastid Sequence Length: 130 Sequence Mass (Da): 13533 Location Topology: Peripheral membrane protein
I3R9R6
MVIELTGSDLTIEDAVACARDHEEVSVSDEALKRVRTARSNLESRIGTGEIIYGVNTGFGASQNEVIDPEDVATLQKNLIRSNAVCIGDPVDEDEARMMMLLRLNSLLSGSSGVRVHVVLKLRDLLNAGFYPHVPRKGSVSASGDLAPLAHVALAMLGEGKARHEDEWVPSSEVLTSIEVDPLTTEEGEPGLEAKEGLALINGTNYITAVGALAVHDAETLLDTADTVGTMTLEAFRGISDPFRAEIHELRNQPGQKHVAERIRNGIEGSELVTSAAEANRAQDSYSLRCIPQVHGASRDTLTHVRGVIERELNAVTDNP...
Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. Catalytic Activity: L-histidine = NH4(+) + trans-urocanate EC: 4.3.1.3 Subcellular Location: Cytoplasm Sequence Length: 517 Sequence Mass (Da): 55254
A0A1S3BTX0
MEQNYSVPEAYLESEQDVSLKQNWKSISTESTISEDANGCFDCNICLDSAADPVVTLCGHLYCWPCIYKWLHVQISSNEPENTQNCPVCKASITPSSLVPLYGRGTSNSDSESKKSHLGMAVPRRPPPSMNTPPPSNSSSASYPSQELHSNYIRSPSHPIYHQQYFPQAYGNFASYAPSYLGNAVITSLLNPTIGMFGETVFTRIFGSVDGNLLPYPPYNNSISGNASTRMRRQEMQLDKSLNRVSIFLFCCFIICLLLF
Pathway: Protein modification; protein ubiquitination. Function: E3 ubiquitin-protein ligase. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellul...
L1JV99
MKKGLGADVKKTKASKKDLLTEIDPICQKIIEDEVLKQFPLHKFLGEESVDPGSAASSKALSELISSEWLWVVDPIDGTTNFAQGMPMSVISIGVAHRGKPVVGVILDPFRDELFHAKLSCGAFLNGQRIVCGSESAVEDSVIVAGSPTNLRSIAPSLRGINALMPHCRSIRMLGSAALHLAWIACGRLTAYFEPDLNSWDTAAGAVILREAGGRLTDLEGSDYQLTTRAVSVSTGFVTRE
Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. EC: 3.1.3.25 Catalytic Activity: a myo-inositol phosphate + H2O = myo-inositol + phosphate Sequence Length: 241 Sequence Mass (Da): 25836
C8XTB7
MAIHLVEYECNLFMMDECFHENDYLVSRPIYSNQIFDQVHERRNQETQSLQERLSRTFGHTDKWAVQKVKGLLPIMEWLPKYPVKQWLPGDVVSGVTTGLVCCLQGVAYALLTSVAPVYGLYSAFFPILTYFVLGTSRHISVGPFPVTCLMVGSVVLTLAPDEHFLRSVNMTDVNETMVEDTLMEVDVEAREAQRVMVACTMTVLVGLMQVAMGLMQVGFLVRYLSDPLVGGFTTAAAFHVFISQIKTILSVPTHNHNGFFSFAYTLIDVGSNINQANMADLIAGLLTISIVMAVKEINTKFQHKIPVPIPIEVIVTVIA...
Function: Sodium-independent transporter of chloride and iodide. Subcellular Location: Membrane Sequence Length: 760 Sequence Mass (Da): 83523 Location Topology: Multi-pass membrane protein
A0A1R1XRL0
MSAPPAFSHLDQPSKPINNNITPWQKKLYINQDYADDYVDKTFLIEFQKNVNVRIYVYWEVVSESIVVTQHFSSILIFIALFIYLYRESVSNYHLLYTSLIGLLIGSLIWDSIMSKHSPPQPLVLNMKMVRSVITFALILYFLSPVLRTLTKDTSSDTIWALTVVFFILNLAFHDYAANNLTRISSIGSISMNAAVLACVLLASRLSSDNAVFAFLVVALLWFALFPLLRRLLIIHSKPCSIVLTIIMVILATVAFFPISKAVSLLCFSLPFFITFLCPIWLIWIQRYKNEIHGPWDEATPIVHK
Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Subcellular Location: Membrane Sequence Length: 305 Sequence Mass (Da): 34814 Location Topology: Multi-pass membrane protein
T1FMS0
MKLFAINILYKGTNGKVKKLTGSSELSSFGFFQRSSAQEFMDFTSKIIVERTNTSQRSSVKEQEYVCHLYVRGDSLAGVVISDDEYPSRVSFTLLNKVLDDFSAKYPAHQWPDAQENSLPFTELAEFLQKYQNPKEADAMTRIQSDLDETKIILHNTIESVLERGEKLDDLVAKSEGLTYQSKAFYKTAKKTNSCCVLL
Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transp...
L1JMG4
MHFRVNTKGISAEAQQAVVDSIRVVPNFPKPGLFFKDLSLLLGNPAAFGSTIDALVHKYAGRGITAVVGIECRGFCFAAPVAIALKVPFVPFRKPGKLPCKSIGIDFKQSAGKHSAYFGKDRLEMHEDGLTAGSKVLVIDDLLGTGSTMFGACELVEKVGATVVECACIVEVKELAGRERVKRDIFILIEDAED
Pathway: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. Catalytic Activity: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine EC: 2.4.2.7 Subcellular Location: Cytoplasm Sequence Length: 194 Sequence Mass (Da): 20824
Q2MLR9
MIMNHFLWLLPLVFPHLSSPVILLERNDGNLFHNWSYQMKGDKMVLHRSKRDWMWRQFFLSEEYMGNNNQYVGKLRSDKDRGDGTARYVLSGEGAGTVFRIDEKSGDLHATQRLDREEKSSYTLQAQAFNRITGLPLEPATEFIVKIHDINDNEPKFTRAVYAASVPEMSDVGTFVIEVNATDADDATYGNSAKLVYSILQGQPYFSVEPETGIVRIALPNMDREVRKDYQVVIQAKDMAGQMGGLSGTTMVNVTLTDVNDSPPRFAYSSYHLSTYESAEIGSTVGRIKANDGDEGENAEMKYRMSDGDGKEYLDIITDE...
Function: Cadherins are calcium-dependent cell adhesion proteins. Subcellular Location: Cell membrane Sequence Length: 785 Sequence Mass (Da): 88270 Location Topology: Single-pass type I membrane protein
L1J5J7
MQGLVRAVRRFGCSNFQRRFASTLVIAEHDNSALNAITRSAVTAASKLGGDVDLLVAGNNCDKVVEEAAKISGVKRVLKASAPHLERRLAEELEALILHAQNSNKYTHIMGASSACTKSVLPRVAAKLDVNQISEVIAIESEDTFVRPIYAGNALATVKSSDAVKVMTTRATSFDKAEMNGSASVEEISSAAVGASEWKSEELSKSDRPELTAANVIVAGGRGLKSSENFQMLYKFADKLGAAVGASRAAVDAGYMPNDAQIGQTGKVVAPDLYFAIGISGFTGAIQHLAGMKDSKTIVAINKDPDAPIFQVSDIGLVDD...
Cofactor: Binds 1 FAD per dimer. Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxi...
T1G7H1
MCPAAVLDRESRRRSIADKVKSYPDFPKPGILFRDMFPLLRNPTDYRECINLFVEEIREKYPSTEVVVGIESRGFLFAPLMAQQLNVAFIPIRKAGKLPGQTISYSYALEYGNDTIEITRESIEAGQHVVVVDDLLATGGTLSASIELMNKAGASVECCMVLLELCDLKGRKKIKSPVYSMIPLN
Pathway: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Catalytic Activity: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine EC: 2.4...
E7FEB4
MMGVRSVCCFLLISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAEKLDALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSDGFISNLTIQRQYFPNDEDQNGAAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTELWMAQALKQLDEGEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLKYFDYQLAKQKKAEKEQSTKEESKKEQETSDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLFCRYF...
Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. EC: 1.14.11.2 Subcellular Location: Endoplasmic reticulum lumen Sequence Length: 541 Sequence Mass (Da): 61877
A0A0A7S3Q9
MNNIAHNYWVIWVTIIIGLLLQIMPWSSSFYIFKPHWLMLILCYWFVALPHRVGITTAFLSGIIIDLFLGTMLGVHAFIFTVIAYLILFRFQLIRNLARWQQCFIIFGLSICYDLLLLLFQIAIYRTITLTPMIFLSSFVDGVLWIWIFSLLRQIRRRFAID
Function: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Subcellular Location: Cell inner membrane Sequence Length: 162 Sequence Mass (Da): 19227 Location Topology: Multi-pass membrane protein
Q1Q1P7
MRNVRLTIEYEGTNYAGWQWQKNAISVQETLTHAVRTVIREEVEIHGAGRTDAGVHALGQVANFKTYSAIPAKQLLRAINFHLPQDITIKDVADMEEGFHARYSATSKVYRYTVLNDWLRTSLNRNFCYVYGFPLDLSKMMTAAQYLIGTHDFTSFTTKALDNKDRIRTIKNLEIQKEGKYIYFVVEANGFLYKMVRTIVGTLLEIGRGKMDVYLIRKLLETGNRDDAGPTAPAKGLCMKEVKY
Function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. EC: 5.4.99.12 Catalytic Activity: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA Sequence Length: 244 Sequence Mass (Da): 27876
A0A1B8RG03
MTTYTITLQNCAFFARHGVHDEEEFLGQRFFVDAELDVVAGEALESDSINDTVNYGIAFTVIEQIVTGKRRYLIESLALDIAKGLCETFPQIRRAKITVRKPNAPVPGVLDFVQVSVEHFA
Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4. Function: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. EC: 4.1.2.25 Catalytic Activity: 7,8-dihydr...
A0A944VL56
MKKKIAIIGGSGFYDVENPAEVEELSIVTPWGPTSDSILKSETDDLEIYFLSRHGRGHLIGPSQVNYRANIYALKFLGVDWILSISAVGSLKEEIPPGMIVVPDQFIDFTKNRFNTFFDEGIVAHVSMAKPVSETLSLSIFEACKKLQLPVQKGGTYVCIEGPQFSSLAESNFYRSLGADIIGMTNMPEAKLAREAEICYSTLALSTDYDCWHKSHDSVTVDEVLKTIKKNVDNAKSIVKEVLNNIPKEKDVYIANALQASIISSIDSITDESKEKLSAIIRRYLLS
Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate....
A0A2C9CH83
MNPLLMLKEYGQSVWLDYIQRGLITTGELRRFVEEYGLGGVTSNPAIFEKAITGSADYADMLDTLQQKKDMDAMAIYEYLAIRDIQDAADVLMPVYEKTGKRDGYVCLEVSPFLANETQGTIVEARRLWKAVGRQNVMVKVPATSEGIPAIEQLISEGINVNVTLLFSRETYEHVTQAYINGLEKLASRGGDVRTIASVASFFVSRIDTLLDSIIEARVKTSAHANEQALLQGIMGKVAIANARLTYQRYKEIFRGDRWQKLAEKGAQTQRVLWASTSTKNPKYRDVTYVEELIGPDTVNTMPLSTIEAFRDHGRPRASL...
Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Catalytic...
A0A1S3BCE4
MISVCSARTIQASPSSIHFFFPRNRRRIDSNVLRFSANFSSRCSDYDEYSEAQSERIANYAGTRLEETVDINPGKVRLDSWISSRINGISRARVQSSIRAGLVSVNGRVIDKVSHNVKAGDVINCTISELQPLRAEPEDIDLDIVYEDEHVLVVNKPAHMVVHPAPGNATGTLVNAILNHCSLPMVSTSTGEHQSDSDVSDDEFSSIEVFSRVSEAPIRPGIVHRLDKGTSGLLVVAKDEHSHAHLSAQFKQHSIERVYISLTCGVPPSTAGRIEIPICRDPNNRIRMTATHGTKNNPHAKHAASRYNVMEILAQGGSSL...
Function: Responsible for synthesis of pseudouridine from uracil. EC: 5.4.99.- Catalytic Activity: a uridine in RNA = a pseudouridine in RNA Sequence Length: 431 Sequence Mass (Da): 47474
A0A6P4ZCP5
MSTGFHLLAVVIIWSQRAQAADILVATNTFGSHWLNLAKIAEALTSRGHIVTVVAPASEKSDLTTKWPSFRYETFGDPEKAPLFIEVLKNTPPEIMFQVLTSITWLDSHMMMNEAATDDCQNMLSDIQLLRRLKNSHYNVVLTYPGMSCGSLVAQYLDLPLVCTLMFMPFVLVVFCCHVTEIQATGVPNPVSYIPTVMLGLTDQMTFLQRVKNTLVYFGLTIMGQVIAERGFDAIASRTIGSNFTIFSALARTDVWLYQTGVMFDYPKPTMPNMVSIAGYMADEAKPLSEDLDSFMQSSGDAGVVIVTFGNLITVMPAER...
Catalytic Activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP EC: 2.4.1.17 Subcellular Location: Membrane Sequence Length: 531 Sequence Mass (Da): 59121 Location Topology: Single-pass membrane protein
X1WFG3
MAELNRQLQEYLAHSKSGAKTISQSSSSTTIDVDGDVPVSGSWFGRWSSPFSGSSSRGATSGQGSSGGFSWPWSSEPDPCLPGLSRSQRLVAFGTCIFFSALCFGLSALYAPLLLLKARKFALLWSLGSVFALLGAAILRGPSKLIATPTPGAAVYLCSLAGTLYAALSLHSTLLTALGACLQIAAIVGYIVALLPGGSAGMRFVGGMAASAIKRTVTGKTMPI
Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Subcellular Location: Membrane Sequence Length: 224 Sequence Mass (Da): 23043 Location Topology: Multi-pass membrane protein
A0A2C9CHJ6
MLLGVHCSIKGSLHNAFNEAASLGIDTFQIFTKNQRQWKEKIVGPAEKTIFRETLRQSNIKTIFSHASYLINLATSDSRIHALTHNSLLGEIQRCDDLGIASIIIHPGFTKNTGKQTGMKNVIKMIKSVLKKTNNSPVKILMENTAGQGSSIGYHFKQLQQLIEGIGSGRIGVCFDTCHAFAAGYDIRTKIGFETTMEELDATVGLNSLYAIHLNDSKGALGSKIDRHEHIGQGAIGLEPFRQIMNTMKHIPKILETPKEGGMDVKNLNILKGLVENR
Cofactor: Binds 3 Zn(2+) ions. Function: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. EC: 3.1.21.2 Catalytic Activity: Endonucleolytic cleavage to 5'-phosphooligonucleotide end-produc...
D3XDB4
MQGCMSLVFLWTSLLLSLPSGYNADKILVFPIDGSHWVNMEVLVKKLQSRGHELSVIRLEDSWFIKGNSPYYSSITVTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEFIGILKVGHGANIAMLTSMLENKVLMSQIKMANYDLMLTDPAMPGGVILAHYLHLPMVYNVRWMSFGEGHFSIAPSPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPMYTSLLLNHFPPGTDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQCRPAKPLPADLEEFMQSSGDHGVVVMSLGTLIAGLPKE...
Catalytic Activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP EC: 2.4.1.17 Subcellular Location: Membrane Sequence Length: 534 Sequence Mass (Da): 59988 Location Topology: Single-pass membrane protein
A0A084J7S2
MNIDWSIIVPSTINFFIFYLILRKFVFNKTLAVINTRKEEVESAFKKARDEEERAKLLKQKYDEDVKRYRNDGLKLVESYKQKADKVYAEIVEDSQREVANIKERATKEIKREREKASKEIKQEIIDLSMKLAEKTLEKEINEESHRELIDKFIAKVGI
Function: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). Subcellular Location: Cell membrane Sequence Length: 159 Sequence Mass (Da): 18916 Location Topology: Single-pass membrane protein
L1INC3
MEAENLLPSESESARRVRTLAKLNEMCRDFVKRVYEKNNLMEQYSEENPPYQLRTFGSYRLDVHLPGADMDTVMIVTRHIHRDDMFNDLYVAMQARKDITNLIKVQEARVPVIKFQMDEFEFDLAMARLSYATIPEDFDVTDDKHLKNVDQQSVTSLNGVRVTDTIRSLVPTMKTLKYCIRALKLWAKKRGVYKNVLGFLGGISLEIMAARIGQLYPKALPSRLLYFFFFTYSQWKWPQPVGLTEVIANSHDLNLPVWGFGATEMSDRRHLMPIITPCYPAQNATANVSKSTLKVMQEEFTRAKDICKQILEGNAEWSDL...
Cofactor: Binds 2 magnesium ions. Also active with manganese. EC: 2.7.7.19 Subcellular Location: Nucleus Sequence Length: 338 Sequence Mass (Da): 38951
H1XR43
MQSAFQLHIDDQNIALLYFDLPDEKVNLFNERVFDELDEILDRLEKAQPAALLILSKKEGIYIAGADVNAFQKIDTLEMGWQAARRGQLVFHRLSKLPFATIAVIHGACMGGGTEMSLACDYRLATDHPKTRIGLPEVRLGILPGWGGTQRLPAVTGLSAALSVILTGKAVSAKKARAIGLVERLLDPHKAVEEQALSFAREAIQKGSKIKKRKIFRVERIGFIRRLIFSQARKRVLKQTQGFYPAPLKAIEVIEKTWNMPIEQGLEVEARALAELIITPQSKNLVRLFIWSEELKKEARNMLSGYQAGQTQRIFFFNVD...
Pathway: Lipid metabolism; fatty acid beta-oxidation. EC: 4.2.1.17 Catalytic Activity: a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH Sequence Length: 669 Sequence Mass (Da): 75782
A0A235BQH3
MRVGLVVNPNKPSSKILVPKITSWLKEKGVTVLDEPDVSSADIVLALGGDGTFLRVARLVDPYDIPILGVNLGGLGFLTDIKEEDVFTALELVLKNDYRLEERITLSLNIMDKSLFALNDVVVSTVKVGRMIDLQLSVDGKHLSEISCDGLIIATPTGSTAYSLSAGGPIVFPHLNVILVTPICAHTLSMRPLILSSKSTLTVTSISGKSMACCDGQVKLPVDTGVPVTVKTGEHTIKLIKFDMSYFEILRRKLGWNKRANQ
Function: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. Catalytic Activity: ATP + NAD(+) = ADP + H(+) + NADP(+) EC: 2.7.1.23 Subcellular Loc...
L1J976
MKDDGHLALGLFFGTITFYHLSEFVLACTYNPSTVSIDSFLANQGSYMGAMLFGMSEYFIGHTFFPASKGWRACRFIGLAGVLFGEFFRKGALIQAGSNFTHKISDGEKRSSHTLVTTGLYSISRHPGYFGWFYWSISTQVLLCNPISTILYSIASWKFFQDRIPYEEYHLCRFFQDYPAYRDRVPTRIPFIP
Catalytic Activity: [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine EC: 2.1.1.100 Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 193 Sequence Mass (Da): 22113 Location To...
A0A183IKL3
MKVIANGFLLHSGAYLRNGWNILDFLIYCTFNSQYSWVRRESFASFSCAATASTGLQVVLNSILRAMVPLFHIALLVLFVIIIYAIIGLELFCGKLHKTCVNANSGEIVGEPGPCGESRTSYHCDHGHDIICTDNHTWPGPNNGITNFDNFGLAMLTVFQCISLEGWTDVMYWVNDAVGCEWPWIYFITLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEDDLKGYLDWITQAEDIEPVNEEEETESTTREGANAAFRKLALFTLLSLLEPVEGEATDEGSKEEFRTQSWWLKRIRRIKKLNRRCRR...
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Subcellular Locat...
B9UVE2
LYLIFGAWAGMVGTALSLLIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPVMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLSGISSILGAINFITTAINMKPPALSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILIL
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
L1JW27
MVLQPSSSEALRLFTCFGLFLLSNSFQAVNIAVRDVNSDKSSTKLYSSQQDTRRICNVFDFRRLVPYQEGLQLQQNLQQDSIKALVGGHQTSDALILLEHPTVYTLGSSSVLSDILFELPDIDITNVGAKVVVEDYPEMPPFSIFRVQRGGKVTYHCPGQLVVYPILDLNYHGKDIERYLRNLEQLIINTLARFGVRGAREEGLTGVWISGKKVAAIGIGASRWITMHGIALNINALMKGFEMIVPCGIKDRDVTSLHQILGDSCPSVEEVKLCLKDEFAKIFELQLCDVEFPNKSSY
Pathway: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. EC: 2.3.1.181 Catalytic Activity: L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] Sequence Length: 298 Sequence Mass (Da): 33289...
L1J5W2
MGKKQHSKDKMYILHSEWQTEGGGYKSKGGLAAKAPHRCLPFFCCSLSLQPFEDPMMTPQGVVYDMLNIIPYVQKNKRCPVTGQPLSVKELTKLTFHKNEKDEYHCPIMFKTFTAHTHIVAIKTSGHVYCHEAIDTLCLKTKNMRDLITDEPFTKKDIITLQDPHNFSNREINKFQHIQSGEDTKARKVAEMKVDEETRRILDKAGLSAPGATGAQRPSQASLLAAEAKAKRAREEAMEAERNDPLKLTSDCASKRKKGISSGAMAASFTSSAIDVHYKVEEQAMSEKEIKQERWRIMRQIGKKGYVQLKTTHGDLNLEI...
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Nucleus Sequence Length: 557 Sequence Mass (Da): 62504
L1JAA8
MGIDEAGRGPVIGPMVYGACIICSKRNNELKEMGFADSKTLTEEKREVLFERIKESNVLGWLVEVLSAKQLSGSMLQRAPYNLNAISHDTAIGMIRKVLAANFNLKKVFVDTVGDPERYESKLSSLFPSIEFAVRKKADSLFPVVSAASICAKVTRDRCVRDWQFKETGVSFSTDYGSGYPSEPQVFGYPDLVRFSWSTTKKIIETQGESFEWEADEMEEDQSQSKINGFFTTQAGWLQMF
Cofactor: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. EC: 3.1.26.4 Catalytic Activity: Endonucleolytic cleavage to 5'-phosphomonoester. Seque...
Q7ZUL4
MADLEMDLQSKRLNNGPENLESPQKSGNEDENGDISGEDEEEGEEEVEMNGEKQDISSKHHSSKHKKKKHKHRSKHKKHKHASEEDKNRKRKHRRKHKKHKRKEEASSSAISRKAEDGSMLLSSANLDDKALLEDLEKQRALIKAELDSQMMGGKVQSGMGLILQGYNSGSEEDEERQRARNGEQRQNSSGGRTRSPRDQIGGMGRSRRDLDTSKPSAKQQSHSHSRERAGRDSKLERATKSAKETVKERSKSKEKKRSRSRDKSKDRGKKSQSPSIRRHSADRKPDQKGRPDRRSSPHMDEKREQVRQRSDSQGGKSQS...
Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. EC: 2.7.11.1 Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Length: 1010 Sequence Mass (Da): 116053
A0A183ICD5
MSNASLNEELVSSFSNTPQRWFHLKKFLERPGPFAHPEFIPSPQNIDFIHQCKILVVGAGGLGCELLKNLGLMGFQDIHVIDMDTIDISNLNRQFLFRHFCRIQDMTADFYQSFSIVISGLDSVSARRWINGMLVGLLHYDENGELDTSSVIPLIDGGTEGFKGNVRVILPGVTPCIECTLSLYPPQVNYPMCTIAHTPRSPEHCVEYVRMILWGKLSPFGTACSLEAFKIASSSALPLNNYMNFQDSDGVYTGVVELQRKVLNFQEDCLVCSQKPQKITFPEDAKLEDIVSFLINSAEYQMKSPSLTALTPKFTTLYMP...
Pathway: Protein modification; protein neddylation. Function: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. EC: 6.2.1.64 Catalytic Activity: ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine. Sequence L...
A0A183IW02
MSGLHGRVKETVNVETAEVERKQKEEKLRRYLQARNVLFEKIRNNVFDEDDGEWQKVPRHVFDAEMSLTEVGLAKNPKSYSAWHHRVWMITVAGVKDDCETELRHCEKALEMDDRNFHCWDYRRFICRFGQRSAAEELAFIDKKVSENFSNYSAWHSRSALLPVVHPPLKTTEDEDGLSNGEETKNLPVDVATFEQELNFVQNAFFTDPEDQSSWFYHNWLFAVSEPRPLNLLQAVFDPATAGICLVFDQAISAETSIVVVSVRRDSNKECLHLHLPWRTSDGTRSCRLLCAPLPDVSLGDLPCLQVEYRQKPSSGKDNR...
Function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. EC: 2.5.1.60 Catalytic Activity: geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] Sequence Length: 5...
L1JXR6
MEQPKKRITAMCTAYGVDGAVRGGMIGLMWGLFQGTYYGWQDQLRGRLLGMHVARNLAANTVGFAAFLGIYQIAHCSMENSRKRSDWKNAAAAGLVTGGVMGLPLAVRTGEPRWALFAAGFTAALTGSLDLARPR
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane ...
A0A822CRH4
MEALARQHLYKPIEVTVGGRSIVCQDVVQNVLIFDDDDQKYAKLLELLGLYQPYGSVLVFVESQIRCDELIKKLMSHSYSCMPLHGGLDQYNRDSTITFFKNGDIPLIIATSVAARGLDVKNLILVVNYDCPNHYEEYVHRCGRTGRAGNVGYAYTFITSAQGKFVGAIIKALETSGASVPAELTLLWDNYVKQMEAQGKKVQDIRGSFGGRHGYNFDSSDKQHKNIQKRMQGILIGLEDVDDDDEEIDQQIESIYKSNRSISTKDEVPVTQNETSSPLETAKRITARLSAIQYENPGVPHDVTLSLAAARQRAQELNAK...
Function: RNA helicase. EC: 3.6.4.13 Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Length: 440 Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Sequence Mass (Da): 49722
T1G0T9
VGHMNVSLEDLMNSTIEKLFENLTSKIELGGSWRPKNCISRHKLAIIIPFRDRENHLNVLLSLLHNMLPRQLLDYRIYVVEQIGNDTFNKAQLMNAGFLEASKQNDFHCYIFHDVDLLPKDDRNLYTCSNQPKHLSVAIDEMKYKLNYLYLVGGVLNIRKEHFLALNGYSNLYWGWGAEDDDMACRMFFSGLRITRPPITIARYKTIKHIKRKPSGLYKR
Pathway: Protein modification; protein glycosylation. Subcellular Location: Membrane Sequence Length: 220 Sequence Mass (Da): 25705 Location Topology: Single-pass type II membrane protein
T1G5Y3
LVLFFFQAVFNYMIPDHKADVFNPPHTTNISNTFVSVLFDGLTNRWDAIYFIHIAEHSYTFENTLVFFPLFPLIVKLLTFSLFYPFTFFLSIRNVLQIVAVLINFILFILSALTLYKFGLAVLKNEHLSYRAAQLFCVNPASIFFSAAYSESLFSLLTFAGLLKLQSNKVLHASILFGLSAATRSNGLVNMGFIVYYFLHFHLKAILKFDLSFCHNLLLFFIYIFLCCSWFIFYQLFAYIIYCEVNKSHFKNLITNELRNYGKEKGYFTLGDSPSPPWCKLTVPISYSSIQNSHWNLGFLKYYQVKQLPNFFLASPMLFI...
Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. EC: 2.4.1.- Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 528 Sequence Mass (Da): 61877 Location Topology: Multi-pass me...
A0A834Y9K3
MELARPGDQILGGNHQLYNVLITAHAPLMIFFMVMPAMIGGSGNWSVPILIGAPDMAFPRSNNISFWLLPPSLLLLLSPALVEVGSGTGWTVYPPLSGITSHSGGAVDSAISSPHLSGVSSILGSINFITTISNMRGPGMTMHRSPLFVWSVPVTAFPLLLSLPVLAGAITMLLTDRNFNTTFSDPAGGGDPILYQHLFRFFGHPEVYIPILPGSGIISHIVSTFSGKPVFGYLGMVYAMISTGVPGSLVRAHHMFTVGSDVDTRAYFTAATMIIAVPTELTDRKEGDLLSLLYSRNRLSTRPGKEKRFKYPATLSFSEA...
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A813X2X2
MDLLHLVNNFSGVLSFANVRAKADDFVIDRLSYKFTSAILCVFALFCGVKSSYTVPIICWTPAQLKRYEKAITAYCFANNTYYVPDDQRVPSTTNERYEGLIIYYQWLPWIFALQAVLFYLPKLIWRLAVSGSQHDIRSLLDNASELYFIPNFGKKKSLTKFRNDKLDYLDSRLFVREDGDIVTDRLHHHSRTFSCYLIICYIGVKLLYLLNCLFQISLIHFMIGTRPFGINRFQHLKEDTFETHFIGQFINKISSGVSELIDTSAFPKRTLCDFTFRELASNHAYTVECILPLNIIVEKMYVFLYIWFIFLAFIIFIDL...
Function: Structural component of the gap junctions. Subcellular Location: Cell membrane Sequence Length: 403 Sequence Mass (Da): 47305 Location Topology: Multi-pass membrane protein
Q1Q760
MSNFIEPITLWPLLLYTVAVVSLVIGILIISYFLGERHKEPSTDVPFESGITPTGSARIRFSAHFYIAAMFFVIFDLEAIFIFAWAVAFRDVGWNGYIGVLIFIGIIIAVLIYVWRLGALDFGPQGKKILSAFEKLKG
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ...
A0A183ISU3
MCIRHKLSRILRSTVARHETTQQASVKSTTENVPMAEVRFDDPKEIYRSKTTAELIRSALILKLCSIELLTRNSERLMNIGRLLLGKSLFKILMKNTIYGQFIAAENFKQLKPEVEKLERNGIRSILDYCIEKDINQRQAKGITEASLEQSLKIILESIDMATAVKGNLQMVAVKVTSITEPLFLAKLNDVIEASQQFLEELYHDSWDNIVQIKTSVEELMTKVKMVRRNAERINSQWIEYVKESADTANKRTDFSKERHFDQTLSWEQFSGAFMPPEKQKAPAWTRNDYQQYKALVGRLSKIADYAATKRVPVMIDAEQ...
Function: Converts proline to delta-1-pyrroline-5-carboxylate. EC: 1.5.5.2 Catalytic Activity: a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+) Sequence Length: 533 Sequence Mass (Da): 61887
T1G567
MFKKKKKQRKKKNKSNDKTEPSKSCYGAQQLLHQHSNGQLQQKQPDDVSSKIDGMENWLDLRIPNPILRCLKELGFTNPTPIQSRVLPSAIEDKMDIIGAAETGSGKTLAFAIPIVTHILNLNADDDDDDDDDDVDTINNNNDTDVDEESQRDTLDVDDINDEEDDDDDEVLGKMHNDDKNDHHHPHHYHHHHHNKPMYALVITPTRELAIQIREHIDNVTKYTDVKCLAIVGGMSIERQNRLLKKFSPQIVVATPGRFWELVQQKCPHLSHVKDLRFLVIDEADRMIEKNHFEELEKIMNYINLNLCSPLRRQNFVFSA...
Function: RNA helicase. EC: 3.6.4.13 Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Length: 543 Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Sequence Mass (Da): 62569
A0A183IHH3
MGIXXXXXXXXXXXXXXXXXXXXXXXSVNCRTSRKFTEILKMHEVHRIALSRRFRARLCSTAALLHVVLFLLTLLLSLLFAFRTHESRFETVQVTEQPTVLYQQQFLIVLTSATSGRYWLWSSSLATNQRERDHLKPSLIRFCVKDYNNDGRPDSFRLIAVFPLAEGEVVYGINALFAFDYSIAERSAVELQAIAHVQHESSHPGLEYRVTGEMKAVQKTPVKLRSPGDTYGQVIDFGKQGISYERLLDLLSRSNNRNLSITFVPHFSKWSEKPANTTADFTLHIKINYLEDTFLHHSCFYEVLKWGWIQFYAVFVILFY...
Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Subcellular Location: ...
T1FFK7
MENLSTSDEYPKHDPDLMRLYSMRFCPYAERIRLMLQFTKIKYEIININIFDKPKWFIANVNPDGTIPVLQYKNAILTQSSICNEYLNEEFGENKFLSKKPLSRAQQRALIASFDKVSTPFSEINKTSDRSVHKANLPKLLDGLGFYEKELKGPFFGNQKYPSLIDIAIWPWFERFPAISKLNHLDIMSEREFPKLSCWVKNMKKLKSVQRVSLPVDYHVKFYEKKQIGFTDIVDIGL
Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). EC: 1.20.4.2 Catalytic Activity: 2 glutathione + H(...
M5C7A2
MGLAVVGTPLNWEETQKCADYIREHGITQFLNIWRKQQNRKDYPFLWGDEIECMVISYDDEGRDARLSLRQSELLPKIQACERRLRQLSPDNADSVPEFQPECNRYMLESAPGSPYNGSIESLLSVEKDMRNRRKLAKAYLLPRESLITLTSFPRLGVREPFTHHPENDPAHSKTSESLFLSGDITSPNARFPSLVANMKSRRGAKVAANIPLYFDTNTPRPFVDPSIPWETGVSPEDRGAIKHDHIYLDTTSFGAGCCCLQVTMQARDVNEARVVYDSLVPITPIMMALTASSPAYRGYLADVDCRWDILEASCDDRTE...
Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2 Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Length: 660 Sequence Mass (Da): 74839
A0A183IH89
MTGKLLHYRNCCFHRVVKNFMIQGGDFTAGNGTGGESIYGGTFADENLELRHDSPFLLSMANRGKDTNCSQFFITTRPTPHLDGVHVVFGKVISGYQINCGELMLVKKSRRRSSGSCSTDEVKITGDRPSKEGAAEAEAKEAESAMTTTPAVEIPDIPPNRFLFRRSKTPEDIKKKENDKEKDKRKEERRDVRERPRTFSRRVLYSKSGHRIRGRGKLR
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. EC: 5.2.1.8 Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Length: 219 Sequence Mass (Da): 24768
A0A815IF77
MRRFPNAHFLVVSDDKSYCKNLFRHRSNIVVTSRTFSIGDDLITLSLCEHSIITGGTFRWWTGYLANDEVIHDKIYPSGCERREYYYPLWFLIDGNVRAYKNGNYTRDVHRG
Pathway: Protein modification; protein glycosylation. EC: 2.4.1.- Subcellular Location: Golgi apparatus Sequence Length: 112 Sequence Mass (Da): 13228 Location Topology: Single-pass type II membrane protein
A0A7C4JBV1
MKDSSIPKKVILASKSDPAAQNIKRHLLRLGNFIEIEKGVYTSQKALLIETSPQSVSLPSGTDEVIVASRHASQSGRPSLTVHVPGLPEKSLLPPASPSTVRAALLELRNQVARLNLPHQVSLEATHHEPGDFAVPITFVEIGSEEKEWVNENAGEAVARAILSALDPHPCKFAIGVGGPHYSPLYTRISFESNIGFGHILSKHAPANVELIRLALEKSSSRMIVLDWKGATREQREICLEISENFGIEVVKAGSLLVKKL
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. EC: 3.1.1.96 Catalytic Activi...
A0A0B7BRW4
YALIGTIHDVIQSKVPFSLGATPFPLDRTTDRMTFFERLKYTIIYIARINFDLFHDSSLVSRFAPHKPYKSINDIAANAEVFIAEVDHILDYPRSVFPNTKLIGGSSASPAKPLVGEFKKFVDESKNGIIVFTFGGSIINVPTQITSKLLSAFQQLDLGVVWKVNITSPDPSRIMTSKWIPQNDLMGHEKAKLFISHCGKNGQYEALYHAVPILCLPIFGDQGYNSERVVIKELGLRADMREASADELASMVKEIVYDGKYTRNMKKASDLYRKLYKVPKKEAAFWLDHVMEYGGAYMRSTAQQMPWYQIFVLDVLAFLF...
Catalytic Activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP EC: 2.4.1.17 Subcellular Location: Membrane Sequence Length: 359 Sequence Mass (Da): 40777 Location Topology: Single-pass membrane protein
A0A815BX94
MDDYSKRCGITSLMGPKRFRPPALTIEDLPNDLDAILISHNHFDHLDYLSVKRLNDRYGERLTWFCGRGTRQWFLVHGVKNVVELDWWEEYHFSKKAVNIAFCPAQHWSRRTAFDMNKALWGGYAVWDHTHKFYVAGDTGYTHNISIFRQIGKKYGPFDLSAIPIGAYEPRWMMEAQHVSPDEAVQIHIDVQSKKSIGIHWGTWALANEYFMEPPEKLSQAVENNQLDPSSFIVVKHGEIFDLS
Cofactor: Binds 2 zinc divalent cations per subunit. EC: 3.1.4.54 Catalytic Activity: H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine Sequence Length: 244 Sequenc...
T1EG16
MAEGGVDKKDSEEELHKEVVELDSKEVVKESACNNNFLQSIAAKFMGLFKSKPEDRSLVSVDLDGVVEFIRSGRCKNIISMAGAGLSTSAGIPDFRSPGSGLYDNLDEYDLPYPAAIFDLSYFKKNPEPFFVLAKNLLPTELIPTPCHHFLKLLHDKGLLMRHYTQNIDTLERLAGLPNEVLVEAHGTFNSGHCLKCRSKYDFDWMKNKIMSDTVPKCMKSGCKGVVKPDVVLFGENLPMKFFSLLIQDFSKCDLLIVLGTSLNVQPFASLVHKVPKKSPRLYVNLQKTSGSSFASWLIGGGSGFKFDDPDNERDVFWKG...
Cofactor: Binds 1 zinc ion per subunit. EC: 2.3.1.286 Catalytic Activity: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide Sequence Length: 352 Sequence Mass (Da): 39451
A0A4Q9P1B9
MATIICRVCLEALQDKTVVSTQCGHLFCSECAGSVFSYIPTPCPICRKPQSSHSLIRLFPEWETPSETVTNTVLGQPAARNVSSPLETPHVVSRLDSDSSTSSTAFQPMSTASRPRRRGLMEDVSGTVDPEAPISTAFRPRRGVPIQLPTARRSVSHTTRSPPSPSDLRRTARGLNAVYVARGPQVTPPVAVVAVQRAPPVTLRSRSMAIAFALDLDISLSRTPRAR
Pathway: Protein modification; protein ubiquitination. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Nucleus Sequence Length: 2...
A0A385I858
WFFGHPEVYILILPGFGLVSHAVMVSSGKPSPFGVPGMFLAITSIGVLGCVVWAHHMFSVGLDMDTRLYFTAATMIIAVPTGIKVFSWLVSFSGSKMLMAPLQLWILGFLFLFTVGGLTGIVLANGTLDLLYHDTYYVVAHFHYV
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A183IDP4
MHGGGFGQFAAVPLNLMSLSKGTAQPSADYFISGSWSKLAAKEASKFLTVTEPIDPPLLQYNEFPEESEWKLNPAAAYAFYCANETIDGLSRDDGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVCDMSSNMATKRIDVSKYGVIFSCTQKTLGIAGLSVVIVRRDLLGHSSARCPSILDYTLQSKANSCFNTPPVFAIYVTRHMLKWMKESGGIVEMQRQTIAKSNMIYEVIDSSHGFYKNRVALRNRSRTTIPFHLLDESMDERFLAQAAERGLHGLRGHRYVNKY
Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. Function: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. EC: 2.6.1.52 Catalytic Activity: 2-oxoglutarate + ...
A0A8H6C4D6
MTSQEIYFYRFLVSKQVFYKSRYTYALVNLKPLVPGHVLVVPLRTNVLRFGDLSPEESVDYMHTLQLIHKFIQKVYKADSLNLAIQDGPESGQSVPHLHTHIIPRHKGDGYGDSIHTMLESDEERVARSESVMSEEAVWLAQNKNDRTPRTSIYDVLSSRLLASVLSIKNSTDLLNDMTSYHISDGGHSYINSIHGSSSKPSQSSAVSKPSSTNTGTNATTTPITLTTPSGATVPSTVSNGISTSTEIASGVFDTLLNDVVMNDDHLYIDEIPLYGEGSTLERLGLKGNKDAGLSL
Function: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside po...
A0A1B3NJN6
MPIVRFINLLSLWSGRVGAVVVVPLVLAMVFEVVSRYAFAAPTQWAFELSYMMMGTIFLLGLSYAVLTDQHVNVDFIHQLLPRRAVATIDAVGYLIMAGMLAWLTNALVGNVASVYRTGEGTGLSAWNPPIWPYRVIYVIGFALFSLQCFAKAIENLLVVFGRATESPAR
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system. Subcellular Location: Cell inner membrane Sequence Length: 170 Sequence Mass (Da): 18745 Location Topology: Multi-pass membrane protein
T1FV65
MWRVPTNLPKCLARTHVAVAVKRNIRTSKVLQSQDVNSAGGGGGGILKKLIALTFAGAGGVVGYSWYDPEFKKLVEENVPYAKECYDAVFQYLPESASTIEDAVKRLPIKTTEITTVPPPVQAPIQEDSKPEVKAEEKVKTKKEREKEKKEEAEKLLKLREENEINQNKALEALLMRTFTESASVMEAAMKSAHSAAEAVKEHTVKLKEALQKVDAKEGEWEAVTRAHDAKVKAMQHFEEVNEKAKQELAKLREVISTGKSNKVTKKNKLLWSTEDEANKLNRSFNTALNEVSKAEADSKVFKEYRDLIKKGKEQFKKEL...
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Subcellular Location: Mitochondrion inner membrane Sequence Length: 69...
A0A183PD56
MISAIKHHNKNIVSHEEGPNIPSDQSIVNSIYDLVNNLGSLAARLLFLPLEESCHFMFSQCIQRDVSPNKQDKKLLMDAFRMLKTALRISSLIAWIGVTYAQANSRLLLMIYAGHRLADNYVAVNLLQLYSAYVLLLAWNGSTEALLNSAMSTVEKVFHVYYINKFLAKIDEPTNIEKQNNLDDDDNDSSCSSSGKSSTFVVLSNCEMEKFSNISLLSLMFPSYSEMCILSISLVCTLISQYFFCCSFGILWMILHGTITFGFLFITLIIIYYEEVDILQLIQNRLPSPLRYKKSQ
Function: May be involved in N-linked oligosaccharide assembly. Subcellular Location: Membrane Sequence Length: 296 Sequence Mass (Da): 33581 Location Topology: Multi-pass membrane protein
A0A183J936
MFVIDKSRYDTTDCYLHPCNAPYNDVDLQYDPNTYSLLVENGVDTMLAKHVAHLFIRDPLQVYKGRIEQDDKLSSEHFETIQSSNWLNMRFKPPPIDASSIGWRVEFRPTEVQLTDFENAAYVCFVVLLTRVMLSYHIIFTIPISEVNENMKRAQK
Pathway: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. EC: 6.3.2.2 Catalytic Activity: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate Sequence Length: 156 Sequence Mass (Da): 18225
A0A183ISY6
MILFGCSKPNHPTGGVWDCEHHSVCDKENPKILFSWARNAPSLSLPDNVGVAVGGDSGIDNYVVQVHYNAKFTGEVLDYSGVVLNVTSLKPRYFADVLLMVSSAYYNIPPHMSEVALNISCTYYGPTPLHIFAYRTHAHSLGRIITGYNILNDQWTLIGKGNPQWPQRFYPTTPEVVAEPGSILAAQCIFNSTTRDTVTYIGAHGKNEMCNFYMYIYVESEYGTMLKQLGECLDSNDTKLFAKYPAEARKPLERNPLLEMEANMTMERFGEN
Cofactor: Binds 2 Cu(2+) ions per subunit. EC: 1.14.17.3 Catalytic Activity: a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical Sequence Length: 272 Sequence Mass (Da): 30484
A0A183NHC3
MFCLNVEIVQCFGFLSYGVLSNRSPTYKRLRAKQLVEVNYLCVHKKLRSKRMAPVLIREVTRRVHLRGRFQALFTSGTLLPKPVSKCRYWHRPLNPRKLLECGFSHLTHNMTLQRTIKLYRLPEAPLVKGFRQMTKKDVPKAWPLLSEYLEKFNIHPIFTKEEFQHFFVPRDDVVYSFIVENGDGQITDFCSFYVLPSSVMKSKQHNSLRAAYSFYNVSTVTPWPALIQDMLISAKQVSLHIYSC
Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. EC: 2.3.1.97 Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] Sequence Length: 245 Sequence Mass (Da): 28681
A0A1S1NT41
MRLRFTGSCAGVPSRQRNVSGLTLQPEHSRRWYLIDCGEGTQHQLMRMSLSLARLEAVLITHVHGDHCYGLPGLLASASMAGRRTPLTLIGPQAVWTFLTAVRETTGLHLDFPLHFIDAATLTESLVLTEFTITAAALSHGIECHGYAFEERGIEASLDTARLEADGVPRGPLWGRLQKGETVYDAQGRQLKGEHYQLMARRPRRLVVSGDNNVPARLTGLCQGADLLVHEATYTEEVIERLGTDNGHCSAARIAAFAEAEGVPNLLLTHFSPRYGRDRRAQNSMAELEREARDRYTGCLALAEDLQPYVLSREGELIIA...
Cofactor: Binds 2 Zn(2+) ions. Function: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. EC: 3.1.26.11 Catalytic Activity: Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA pr...
A0A0B7B0I7
MVLSQLLLRKRVGQAFVLLGLTTTIMCLWIAQHEWEYHSSDTHSLRRHLNGDKVREYVFVNALLDEIHGDADIKQDSNDYNDMLQQKISDKSSEPSFQEPCPLYPSDVLVGRLAGIKECVAPEELALMYPDVEVGGRVRPKNCTAAEKVAIIIPFRKRFTHLYILMNNLIPLLQRQLIDARFFIIEQAMPTTFNRASLFNIGFLEALKFDNYDCFIFHDVDLIPLNDKNLYRCDDHPIHFAVAMDKYNYQLPYKTYFGGVVGFTKEQYLKINGNSNLYFGWGGEDDDLYERIINKKYEIARPYNDVGKYDMIRHIQDSGN...
Pathway: Protein modification; protein glycosylation. Function: Catalyses the transfer of galactose onto proteins or lipids. EC: 2.4.1.- Subcellular Location: Membrane Sequence Length: 404 Sequence Mass (Da): 46953 Location Topology: Single-pass type II membrane protein
T1G1I0
EEKPVKIDKWDGSALKNALDDHTKKIFKEKFGYVESFRLMDGRLILCTISVVFALFAFAWDYIYPFPKSRDVLIICIYYTYFVMMLVLTIYMTYIEKGCFMLALEKDKTMLDPDNIWKLTSKLKRFDDKYELHISYTNGISKKNKSGHFVKSVCNFFDEEGQLCENSFEKEVLNLHASLSPNKKEN
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the tr...
A0A183J6C5
MDCLNQLGSVPWIVNKRVLDVMLTIFRDKGDEKLSIPRSPWNLPKLPKIISADHQEMVKIXXXXXXXXXXXXXXXXXXXXXXEIKKLRTKVYSLWCATLYKLSIANHFRDRVLFFPHNLDFRGRVYPFPRYFNHIGDDVSRGLLKFAKGYPLGKDGLNWLKLHCVNLTGSKKRDAVAIRLKYAEEKMDDILDSADNPLTGRRWWTKSDEPWQTLACCIEIADAVRSPNPEEHICHFPVHQDGSCNGLQHYAALGRDSIGAHQVNLRAVDTPQDVYSGVATLVEAKRQRDAAAGMAIAQSLKGVVKRKLVKQTVMTTVYGV...
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. EC: 2.7.7.6 Catalytic Activity: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) Sequence Length: 470 Sequence Mass (Da): 54268
A0A2D0V164
LLTDRNFNTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGMISQIIPTFVAKKQIFGYLGMVYAMLSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWLATIFGGTLRLDTPMLWAMGFVFLFTLGGLTGVVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWLGKITGYCYNELYGKAHFWLMFIGVNLTFFPQHFLGLTGFPRRYSDFADYFAGWNLVSSLGSTISIVGVVFFIYIIYDVYVWEEQFIAWIEDGGESWASLEWAHFSPPSFHTYEVLPLLYDADKNIKYFRMF...
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A7G9AE66
EDFDRREIVRKTWGREGLVNGEQIQRVFLLGTPKNRTVLATWETLMHQESQTYRDILLWDFTDTFFNLTLKEIHFLSWAAEFCHNVKFIFKGDADVFVNVENIVDFLKRHDPTEDLFVGDIIYNARPIRVRKSKYYIPESMYGLSIYPAYAGGGGFLLSSCTMRKLSRACREVELFPIDDVFLGMCLQRISLKPILHEGFKTFGIVKPSAAPHLQTFDPCFYKDLMVVHSLKVA
EC: 2.4.1.- Subcellular Location: Golgi apparatus membrane Sequence Length: 234 Sequence Mass (Da): 27157 Location Topology: Single-pass type II membrane protein
T1EE36
MEYMATSSPSSSPEWPAKFSHIRKVLGRAGPLSCPDFEPGPENLNFLQNVCKVLIIGAGGLGCELLKDLALFGFCNIHIIDMDTIDLSNLNRQFLFRHHDIGKPKAIVAAEFIKSRISDCNVTPHYAKIQDFYSEFYREFHIIVCGLDSIVARRWINGLLVSMLVYDDDGNLDQSSIIPLVDGGTEGFKGNVRVILPGLTPCIECTLDFYPPQVNYPLCTIAHTPRLPEHCIEYVRLLLWPKENPFGDTVSIDGDNPEHIQWILKKAVERGNEFNIHDITYRLTQGVVKNIIPAVASTNAVIAALCATEVFKLAVSCYSP...
Pathway: Protein modification; protein neddylation. Function: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. EC: 6.2.1.64 Catalytic Activity: ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine. Sequence L...
H9LDA7
YIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYTKTFQGPPHGIQVERDKSNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEAIFKSQAETGEIKGHYLNATAGTSEEMMKRAECARELGVPIVMHDYLTGGFTANTSLAHYCRNNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPG...
Cofactor: Binds 1 Mg(2+) ion per subunit. Catalytic Activity: 2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O EC: 4.1.1.39 Subcellular Location: Plastid Sequence Length: 379 Sequence Mass (Da): 42192
V5IQZ6
MNDISDNSSNSLANGGTVANSDIPKDGTGVLSIDPWLEPFKDTLKSRYSKAQSWIDTINKTEGGLEKFSRGTEIFGFNVDKDNTITYREWAPNAKQASLIGEFNNWDRNAHRMKKNEFGVFEITIPPTANGQPAIPHNSKIKITLELPDGQWVDRLPAWIKYVTQDLSVSPAYEARFWNPPQSERYTFKHKRPSKPESLRIYEAHVGISSPECKVATYKEFTKTMLPRIKNLGYNAIQLMAIMEHAYYASFGYQVNSFFAASSRYGPPEDLKELVDTAHAMGIAVLLDVVHSHASKNVLDGLNEFDGTDHQYFHGGGRGK...
Pathway: Glycan biosynthesis; glycogen biosynthesis. EC: 2.4.1.18 Catalytic Activity: Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. Sequence Length: 705 Sequence Mass (Da): 80524
T1F2C9
MKRQKCFYFNDDDEPKKKKFNADLDSLILDTNPDCIDHTSSPRFRYPTEVGFFSLDSESNFRDDNSSLTYLYGKRLKNKKLNLDLKVGYDTFVGKKENDIQGLGDIFKWISLHPPFNTLTKKGEKLKSLQTDFICWRGLLRKFLCTPYELNENWLIIVRKFKGTHYLVEIKTDEKKQEEREQTTRLKEMSYWGFKFEQYMTTEKPDGKPVTNVPVNNHKQFVSVFLEEKLIAKKIKMTRYKLLKWWSQSILIGVKKIVAGFRDDDGIVREVTKLYTKNIPDQCQSIRNAWNPKVCFNFLDKLLDFIRENVTDENRSYMFE...
Function: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. EC: 3.6.1.- Subcellular Location: Nucleus Sequence Length: 429 Sequence Mass (Da): 49664
T1FQG8
MCHLICRYHQCVFISVHSWKQVVGPVWIAVIYVNQVAYAVSLVAEGSKMDETSECFSLSKLNVRHLVAIILFALATNVQYKTFAYLASLRRNKAGHVVTTNYKPPNAGMFQQLNLSSPHYFAEIVIYFAVLVAMGTNCLTWMTVTYCVACHMTYLAYVTHQYYLDTFSNVYPKHRNIIIPFLF
Pathway: Protein modification; protein glycosylation. Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-gly...
A0A1E7U006
MRARFVPPLILVLLLVILQWQLWNGRGSVREVAQLRTQLADQKDANAKAALNNERLASEVNDLKDGLEMVEERARAELGMVKPNEVFVQIAH
Function: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Subcellular Location: Cell inner membrane Sequence Length: 92 Sequence Mass (Da): 10416 Location Topolog...
T1FZU4
LSSGNSSNDLASLFECPVCFDYALPPIMQCQSGHIVCSHCRPKLQFCPTCRGALGNIRNLAMEKVASQVLFPCRYMSNGCEASLPHTDKANHEDGCEFRPYNCPCPGASCKWQGSLEQVMPHLLQQHKSITTLQGEDIVFLATDINLPGAVDWVMMQTCFGHHFMLVLEKQEKSEGNQLFYTIVQLIGTRKQAESFAYRLELNGQKRRLTWEATPRSIHDGVQSAINSSDCLVFDTNVARLFADNGNLSINVTINTC
Pathway: Protein modification; protein ubiquitination. Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ub...