instance_id stringlengths 9 18 | patient_vignette stringlengths 52 559 | question stringlengths 52 139 | options dict | answer listlengths 1 5 | taxonomy_clinical_department stringclasses 11
values | taxonomy_clinical_system stringclasses 9
values | taxonomy_drug_categories listlengths 1 4 | taxonomy_patient_info_type stringclasses 8
values | taxonomy_population_source stringclasses 3
values | taxonomy_reasoning_operation stringclasses 5
values | benchmark_task_family stringclasses 2
values |
|---|---|---|---|---|---|---|---|---|---|---|---|
CS-A1-006 | A 77-year-old woman is reviewed for routine medication safety. She has no history of syncope and no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Metformin",
"B": "Bisoprolol",
"C": "Loratadine",
"D": "None of the above need to be avoided",
"E": "Famotidine"
} | [
"D"
] | neurology | nervous system | [
"antidiabetics",
"antihistamines",
"h2-receptor antagonists"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-A1-007 | A 75-year-old man has a history of syncope and urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "None of the above need to be avoided",
"B": "Bisoprolol",
"C": "Loratadine",
"D": "Metformin",
"E": "Terazosin"
} | [
"E"
] | neurology | nervous system | [
"alpha-1 receptor blockers"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-A1-008 | A 75-year-old man is reviewed for routine medication safety. He has no history of syncope and no urinary symptoms. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Bisoprolol",
"B": "None of the above need to be avoided",
"C": "Metformin",
"D": "Loratadine",
"E": "Famotidine"
} | [
"B"
] | neurology | nervous system | [
"antidiabetics",
"antihistamines",
"h2-receptor antagonists"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-001 | A 75-year-old man presents for a medication safety review. He has benign prostatic hyperplasia (BPH). He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "None of the above need to be avoided",
"B": "Loratadine",
"C": "Bisoprolol",
"D": "Metformin",
"E": "Oxybutynin"
} | [
"E"
] | urology | urinary system | [
"multiple drug categories (composite rules)"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-002 | A 75-year-old man presents for a medication safety review. He has benign prostatic hyperplasia (BPH). He also has urge urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Bisoprolol",
"B": "Loratadine",
"C": "None of the above need to be avoided",
"D": "Oxybutynin",
"E": "Metformin"
} | [
"C"
] | urology | urinary system | [
"antihistamines",
"antidiabetics"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-003 | A 75-year-old man presents for a medication safety review. He has no benign prostatic hyperplasia. He also has urge urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Loratadine",
"B": "Metformin",
"C": "Oxybutynin",
"D": "Bisoprolol",
"E": "None of the above need to be avoided"
} | [
"E"
] | urology | urinary system | [
"antihistamines",
"antidiabetics"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-004 | A 75-year-old man presents for a medication safety review. He has no benign prostatic hyperplasia. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Metformin",
"B": "Acetaminophen",
"C": "Loratadine",
"D": "None of the above need to be avoided",
"E": "Bisoprolol"
} | [
"D"
] | urology | urinary system | [
"antidiabetics",
"antipyretic analgesics",
"antihistamines"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-005 | A 75-year-old man has benign prostatic hyperplasia. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Oxybutynin",
"B": "Bisoprolol",
"C": "Tolterodine",
"D": "None of the above need to be avoided",
"E": "Metformin"
} | [
"A",
"C"
] | urology | urinary system | [
"multiple drug categories (composite rules)"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-006 | A 75-year-old man has BPH and urge urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Metformin",
"B": "Oxybutynin",
"C": "Tolterodine",
"D": "None of the above need to be avoided",
"E": "Bisoprolol"
} | [
"D"
] | urology | urinary system | [
"antidiabetics"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-007 | A 75-year-old woman has lower urinary tract symptoms but no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Bisoprolol",
"B": "Metformin",
"C": "None of the above need to be avoided",
"D": "Loratadine",
"E": "Acetaminophen"
} | [
"C"
] | urology | urinary system | [
"antidiabetics",
"antihistamines",
"antipyretic analgesics"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-AC-008 | A 75-year-old man has BPH. He has no urinary incontinence. Solifenacin is being considered. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided in this patient? | {
"A": "Loratadine",
"B": "Solifenacin",
"C": "Bisoprolol",
"D": "Metformin",
"E": "None of the above need to be avoided"
} | [
"B"
] | urology | urinary system | [
"multiple drug categories (composite rules)"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-DE-001 | A 78-year-old man is evaluated for medication safety. He has benign prostatic hyperplasia (BPH). He is currently experiencing delirium. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided given this patient's conditions? | {
"A": "Bisoprolol",
"B": "Oxybutynin",
"C": "Acetaminophen",
"D": "Famotidine",
"E": "None of the above need to be avoided"
} | [
"B",
"D"
] | neurology | nervous system | [
"h2-receptor antagonists"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-DE-002 | A 78-year-old man is evaluated for medication safety. He has benign prostatic hyperplasia (BPH). He is fully alert with no delirium. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided given this patient's conditions? | {
"A": "Acetaminophen",
"B": "None of the above need to be avoided",
"C": "Oxybutynin",
"D": "Bisoprolol",
"E": "Famotidine"
} | [
"C"
] | neurology | nervous system | [
"multiple drug categories (composite rules)"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-DE-003 | A 78-year-old man is evaluated for medication safety. He has no BPH. He is currently experiencing delirium. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided given this patient's conditions? | {
"A": "None of the above need to be avoided",
"B": "Famotidine",
"C": "Oxybutynin",
"D": "Bisoprolol",
"E": "Acetaminophen"
} | [
"C"
] | neurology | nervous system | [
"h2-receptor antagonists"
] | composite clinical context | older adults | static risk identification | guideline_following |
CS-DE-004 | A 78-year-old man is evaluated for medication safety. He has no BPH. He is fully alert with no delirium. He has no urinary incontinence. No other significant past medical history; Renal and hepatic function are normal; not on other prescription medications; no known drug allergies. | Which of the following medications should be avoided given this patient's conditions? | {
"A": "Bisoprolol",
"B": "Famotidine",
"C": "Cilostazol",
"D": "Metformin",
"E": "None of the above need to be avoided"
} | [
"E"
] | neurology | nervous system | [
"h2-receptor antagonists",
"pde3 inhibitors/peripheral vascular drugs",
"antidiabetics"
] | composite clinical context | older adults | static risk identification | guideline_following |
DDI-RK-POS-001 | A 72-year-old man with CKD Stage 3b (eGFR 38 mL/min) is currently taking aliskiren for hypertension. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amiloride",
"B": "Metoprolol",
"C": "Amlodipine",
"D": "Omeprazole",
"E": "None of the above"
} | [
"A"
] | cardiology | cardiovascular system | [
"renin-angiotensin system inhibitors"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-RK-POS-002 | A 68-year-old woman with CKD Stage 3a (eGFR 51 mL/min) is currently taking triamterene for fluid retention. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amlodipine",
"B": "Aliskiren",
"C": "Atorvastatin",
"D": "None of the above",
"E": "Metoprolol"
} | [
"B"
] | nephrology | urinary system | [
"potassium-sparing diuretics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-RK-NEG-001 | A 72-year-old man with normal renal function (eGFR 82 mL/min) is currently taking aliskiren for hypertension. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amiloride",
"B": "Metoprolol",
"C": "Amlodipine",
"D": "None of the above",
"E": "Omeprazole"
} | [
"D"
] | cardiology | cardiovascular system | [
"renin-angiotensin system inhibitors"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-OB-POS-001 | A 75-year-old woman is on long-term opioid therapy for chronic musculoskeletal pain. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Lorazepam",
"B": "None of the above",
"C": "Acetaminophen",
"D": "Omeprazole",
"E": "Amlodipine"
} | [
"A"
] | pain medicine | nervous system | [
"opioids"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-OB-POS-002 | A 70-year-old man is on scheduled opioid analgesia for chronic cancer pain. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Atorvastatin",
"B": "Ondansetron",
"C": "Metoprolol",
"D": "Temazepam",
"E": "None of the above"
} | [
"D"
] | pain medicine | nervous system | [
"opioids"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-OG-NEG-001 | A 73-year-old man on long-term opioid therapy is being deliberately transitioned to pregabalin by his physician, with the explicit goal of tapering and discontinuing opioid use. | Which of the following medications would be inappropriate to prescribe during this transition? | {
"A": "Pregabalin",
"B": "None of the above",
"C": "Acetaminophen",
"D": "Omeprazole",
"E": "Metoprolol"
} | [
"B"
] | pain medicine | nervous system | [
"opioids"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-AC-POS-001 | A 70-year-old woman is taking amitriptyline for depression. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "None of the above",
"B": "Diphenhydramine",
"C": "Loratadine",
"D": "Omeprazole",
"E": "Atorvastatin"
} | [
"B"
] | psychiatry | nervous system | [
"tricyclic antidepressants/anticholinergics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-AC-POS-002 | A 74-year-old man is taking hydroxyzine for anxiety. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Cetirizine",
"B": "Dicyclomine",
"C": "Metoprolol",
"D": "None of the above",
"E": "Acetaminophen"
} | [
"B"
] | pulmonology | respiratory system | [
"first-generation antihistamines/anticholinergics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-AC-NEG-001 | A 70-year-old woman is taking amitriptyline for depression. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Loratadine",
"B": "Atorvastatin",
"C": "Omeprazole",
"D": "None of the above",
"E": "Metoprolol"
} | [
"D"
] | psychiatry | nervous system | [
"tricyclic antidepressants/anticholinergics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-POS-001 | A 72-year-old man is currently taking gabapentin for neuropathic pain. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "None of the above",
"B": "Lorazepam",
"C": "Metoprolol",
"D": "Omeprazole",
"E": "Acetaminophen"
} | [
"B"
] | neurology | nervous system | [
"gabapentinoids"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-POS-002 | A 75-year-old woman is taking zolpidem for insomnia. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Omeprazole",
"B": "None of the above",
"C": "Amitriptyline",
"D": "Amlodipine",
"E": "Atorvastatin"
} | [
"C"
] | psychiatry | nervous system | [
"z-class hypnotics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-POS-003 | A 68-year-old man is taking quetiapine for bipolar disorder. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Metoprolol",
"B": "Omeprazole",
"C": "Cyclobenzaprine",
"D": "Levothyroxine",
"E": "None of the above"
} | [
"C"
] | psychiatry | nervous system | [
"antipsychotics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-POS-004 | A 71-year-old woman is taking clonazepam for anxiety. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "None of the above",
"B": "Amlodipine",
"C": "Acetaminophen",
"D": "Metoprolol",
"E": "Methocarbamol"
} | [
"E"
] | psychiatry | nervous system | [
"benzodiazepines"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-NEG-001 | A 72-year-old man is currently taking gabapentin for neuropathic pain. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Metoprolol",
"B": "Omeprazole",
"C": "Amlodipine",
"D": "Atorvastatin",
"E": "None of the above"
} | [
"E"
] | neurology | nervous system | [
"gabapentinoids"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-CN-POS-005 | A 78-year-old woman is taking haloperidol for behavioral symptoms of dementia. Her physician is considering additional medications. | Which of the following medications would be inappropriate to add to this patient's regimen? Select all that apply. | {
"A": "Omeprazole",
"B": "Lorazepam",
"C": "Metoprolol",
"D": "Zolpidem",
"E": "None of the above"
} | [
"B",
"D"
] | psychiatry | nervous system | [
"antipsychotics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-LI-POS-001 | A 65-year-old woman with bipolar disorder is taking lithium for mood stabilization. She is newly diagnosed with hypertension. | Which of the following medications would be inappropriate to add to this patient's regimen? Select all that apply. | {
"A": "Lisinopril",
"B": "Amlodipine",
"C": "Metoprolol",
"D": "None of the above",
"E": "Furosemide"
} | [
"A",
"E"
] | psychiatry | nervous system | [
"lithium"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-LI-POS-002 | A 65-year-old woman with bipolar disorder is taking lithium for mood stabilization. She develops lower extremity edema. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amlodipine",
"B": "None of the above",
"C": "Metoprolol",
"D": "Furosemide",
"E": "Atorvastatin"
} | [
"D"
] | psychiatry | nervous system | [
"lithium"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-LI-POS-003 | A 65-year-old man with bipolar I disorder is taking lithium. His new cardiologist is reviewing his medication list for potential interactions. | Which of the following medications would be inappropriate to add to this patient's regimen? Select all that apply. | {
"A": "Atorvastatin",
"B": "None of the above",
"C": "Lisinopril",
"D": "Metoprolol",
"E": "Furosemide"
} | [
"C",
"E"
] | psychiatry | nervous system | [
"lithium"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-AL-POS-001 | A 74-year-old woman with hypertension is taking terazosin. She develops lower extremity edema and her physician considers adding a diuretic. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Furosemide",
"B": "Omeprazole",
"C": "Metoprolol",
"D": "Atorvastatin",
"E": "None of the above"
} | [
"A"
] | cardiology | cardiovascular system | [
"nonselective alpha-1 receptor blockers"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-AL-NEG-001 | A 76-year-old man with hypertension is taking doxazosin. He develops lower extremity edema and his physician considers adding a diuretic. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Furosemide",
"B": "None of the above",
"C": "Omeprazole",
"D": "Metoprolol",
"E": "Atorvastatin"
} | [
"B"
] | cardiology | cardiovascular system | [
"nonselective alpha-1 receptor blockers"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-PH-POS-001 | A 69-year-old man taking phenytoin for epilepsy develops a urinary tract infection. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Trimethoprim-sulfamethoxazole",
"B": "Amoxicillin",
"C": "None of the above",
"D": "Nitrofurantoin",
"E": "Doxycycline"
} | [
"A"
] | neurology | nervous system | [
"antiepileptics"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-TH-POS-001 | A 71-year-old man with COPD is taking theophylline. He reports new heartburn symptoms. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Cimetidine",
"B": "Famotidine",
"C": "None of the above",
"D": "Omeprazole",
"E": "Pantoprazole"
} | [
"A"
] | pulmonology | respiratory system | [
"theophyllines"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-TH-POS-002 | A 71-year-old man with COPD is taking theophylline. He develops an acute respiratory tract infection requiring antibiotics. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amoxicillin",
"B": "Azithromycin",
"C": "None of the above",
"D": "Ciprofloxacin",
"E": "Doxycycline"
} | [
"D"
] | pulmonology | respiratory system | [
"theophyllines"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-TH-POS-003 | A 71-year-old man with COPD is taking theophylline. His physician is reviewing medications for potential drug interactions. | Which of the following medications would be inappropriate to add to this patient's regimen? Select all that apply. | {
"A": "Famotidine",
"B": "Cimetidine",
"C": "None of the above",
"D": "Azithromycin",
"E": "Ciprofloxacin"
} | [
"B",
"E"
] | pulmonology | respiratory system | [
"theophyllines"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-WA-POS-001 | A 72-year-old woman with persistent atrial fibrillation is taking warfarin. She lives in a rural area with unreliable access to INR monitoring, and her INR levels have been difficult to control. Her cardiologist is considering additional medication for rate or rhythm management. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amiodarone",
"B": "Metoprolol",
"C": "Atenolol",
"D": "Flecainide",
"E": "None of the above"
} | [
"A"
] | cardiology | cardiovascular system | [
"anticoagulants"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-WA-POS-002 | A 72-year-old woman taking warfarin for atrial fibrillation develops a urinary tract infection. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amoxicillin",
"B": "Nitrofurantoin",
"C": "Ciprofloxacin",
"D": "None of the above",
"E": "Doxycycline"
} | [
"C"
] | cardiology | cardiovascular system | [
"anticoagulants"
] | drug interaction | older adults | static risk identification | guideline_following |
DDI-WA-POS-003 | A 72-year-old woman taking warfarin for atrial fibrillation develops a urinary tract infection resistant to first-line antibiotics. | Which of the following medications would be inappropriate to add to this patient's regimen? | {
"A": "Amoxicillin",
"B": "None of the above",
"C": "Trimethoprim-sulfamethoxazole",
"D": "Doxycycline",
"E": "Fosfomycin"
} | [
"C"
] | cardiology | cardiovascular system | [
"anticoagulants"
] | drug interaction | older adults | static risk identification | guideline_following |
RK-CIP-NEG-001 | A 73-year-old woman presents with a complicated urinary tract infection. Her kidney function is stable with an estimated CrCl of 75 mL/min. She has no known drug allergies. Her physician is selecting an antibiotic regimen. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Doxycycline",
"C": "Ciprofloxacin",
"D": "Amoxicillin-clavulanate",
"E": "Azithromycin"
} | [
"A"
] | nephrology | urinary system | [
"fluoroquinolone antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-CIP-POS-001 | A 76-year-old man presents with a complicated urinary tract infection. He has chronic kidney disease with an estimated CrCl of 18 mL/min. His physician is selecting an antibiotic. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Azithromycin",
"C": "Doxycycline",
"D": "Clindamycin",
"E": "Ciprofloxacin"
} | [
"E"
] | nephrology | urinary system | [
"fluoroquinolone antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-NIT-POS-001 | A 72-year-old woman presents with a urinary tract infection. Her estimated CrCl is 18 mL/min. Her physician is selecting an antibiotic. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Azithromycin",
"B": "None of the above",
"C": "Doxycycline",
"D": "Nitrofurantoin",
"E": "Fosfomycin"
} | [
"D"
] | nephrology | urinary system | [
"urinary antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TMP-POS-001 | A 78-year-old woman requires trimethoprim-sulfamethoxazole for Pneumocystis jirovecii prophylaxis. Her estimated CrCl is 22 mL/min. | Which of the following medications requires dose reduction (rather than complete avoidance) given this patient's renal function? | {
"A": "Trimethoprim-sulfamethoxazole",
"B": "None of the above",
"C": "Clindamycin",
"D": "Azithromycin",
"E": "Doxycycline"
} | [
"A"
] | nephrology | urinary system | [
"antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TMP-POS-002 | An 80-year-old man with advanced chronic kidney disease requires antibiotic coverage. His estimated CrCl is 10 mL/min. His physician is reviewing antibiotic options including trimethoprim-sulfamethoxazole. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Trimethoprim-sulfamethoxazole",
"B": "Amoxicillin",
"C": "Azithromycin",
"D": "None of the above",
"E": "Doxycycline"
} | [
"A"
] | nephrology | urinary system | [
"antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-KSP-NEG-001 | A 75-year-old man with heart failure and hypertension is managed with multiple medications. His estimated CrCl is 48 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Triamterene",
"B": "Furosemide",
"C": "Spironolactone",
"D": "Amiloride",
"E": "None of the above"
} | [
"E"
] | nephrology | urinary system | [
"potassium-sparing diuretics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-KSP-POS-001 | A 74-year-old man with chronic kidney disease and multiple comorbidities has an estimated CrCl of 45 mL/min. His physician is reviewing his current medication list for agents that may require dose adjustment. | Which of the following medications requires dose reduction given this patient's renal function? Select all that apply. | {
"A": "None of the above",
"B": "Metoprolol",
"C": "Gabapentin",
"D": "Famotidine",
"E": "Amiloride"
} | [
"C",
"D"
] | nephrology | urinary system | [
"potassium-sparing diuretics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DAB-POS-001 | A 79-year-old woman with nonvalvular atrial fibrillation has an estimated CrCl of 18 mL/min. Her physician is evaluating anticoagulation options. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Warfarin",
"B": "Apixaban",
"C": "None of the above",
"D": "Dabigatran",
"E": "Heparin"
} | [
"D"
] | nephrology | urinary system | [
"direct thrombin inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DOF-NEG-001 | A 72-year-old man with persistent atrial fibrillation is being evaluated for dofetilide for rhythm control. His estimated CrCl is 75 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Flecainide",
"B": "None of the above",
"C": "Dofetilide",
"D": "Amiodarone",
"E": "Metoprolol"
} | [
"B"
] | nephrology | urinary system | [
"antiarrhythmics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DOF-POS-001 | A 76-year-old woman with persistent atrial fibrillation is being considered for dofetilide. Her estimated CrCl is 35 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Dofetilide",
"B": "None of the above",
"C": "Amiodarone",
"D": "Metoprolol",
"E": "Diltiazem"
} | [
"A"
] | nephrology | urinary system | [
"antiarrhythmics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DOF-POS-002 | An 80-year-old man with persistent atrial fibrillation has an estimated CrCl of 12 mL/min. His physician is reviewing antiarrhythmic options. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Amiodarone",
"B": "None of the above",
"C": "Metoprolol",
"D": "Diltiazem",
"E": "Dofetilide"
} | [
"E"
] | nephrology | urinary system | [
"antiarrhythmics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-EDO-POS-001 | A 77-year-old man with atrial fibrillation requires anticoagulation. His estimated CrCl is 30 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Heparin",
"B": "Apixaban",
"C": "None of the above",
"D": "Warfarin",
"E": "Edoxaban"
} | [
"E"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-EDO-POS-002 | An 83-year-old woman with atrial fibrillation has an estimated CrCl of 10 mL/min due to advanced chronic kidney disease. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "None of the above",
"B": "Heparin",
"C": "Warfarin",
"D": "Apixaban",
"E": "Edoxaban"
} | [
"E"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-ENO-POS-001 | A 78-year-old woman with a pulmonary embolism has an estimated CrCl of 18 mL/min. She requires anticoagulation. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Enoxaparin",
"B": "None of the above",
"C": "Apixaban",
"D": "Warfarin",
"E": "Unfractionated heparin"
} | [
"A"
] | nephrology | urinary system | [
"low-molecular-weight heparin anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-FON-POS-001 | A 75-year-old man with a deep vein thrombosis has an estimated CrCl of 18 mL/min. His physician is selecting anticoagulation. Enoxaparin at this CrCl requires dose reduction but can still be used. | Which of the following medications should be avoided (rather than dose-adjusted) given this patient's renal function? | {
"A": "Fondaparinux",
"B": "Apixaban",
"C": "Enoxaparin",
"D": "Warfarin",
"E": "None of the above"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-RIV-POS-001 | A 76-year-old woman with venous thromboembolism has an estimated CrCl of 40 mL/min. Her physician is reviewing anticoagulation options. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Dabigatran",
"B": "None of the above",
"C": "Warfarin",
"D": "Apixaban",
"E": "Rivaroxaban"
} | [
"E"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-RIV-POS-002 | An 81-year-old man with atrial fibrillation has an estimated CrCl of 10 mL/min due to advanced chronic kidney disease. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Heparin",
"B": "Rivaroxaban",
"C": "None of the above",
"D": "Warfarin",
"E": "Apixaban"
} | [
"B"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-BAC-NEG-001 | A 71-year-old woman with spasticity due to multiple sclerosis is being considered for baclofen. Her estimated eGFR is 75 mL/min/1.73 m². | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Diazepam",
"B": "Tizanidine",
"C": "None of the above",
"D": "Cyclobenzaprine",
"E": "Baclofen"
} | [
"C"
] | nephrology | urinary system | [
"muscle relaxants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-BAC-POS-001 | A 75-year-old man with severe spasticity secondary to spinal cord injury has an estimated eGFR of 38 mL/min/1.73 m². | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Cyclobenzaprine",
"B": "Baclofen",
"C": "None of the above",
"D": "Diazepam",
"E": "Tizanidine"
} | [
"B"
] | nephrology | urinary system | [
"muscle relaxants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DUL-POS-001 | A 74-year-old woman with depression and diabetic neuropathy has an estimated CrCl of 18 mL/min. Her physician is considering antidepressant options with dual benefit for neuropathic pain. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "None of the above",
"B": "Sertraline",
"C": "Escitalopram",
"D": "Duloxetine",
"E": "Venlafaxine"
} | [
"D"
] | nephrology | urinary system | [
"antidepressants/analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-GPT-NEG-001 | A 72-year-old man with postherpetic neuralgia has an estimated CrCl of 75 mL/min. His physician is considering neuropathic pain medications. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Amitriptyline",
"B": "Gabapentin",
"C": "None of the above",
"D": "Capsaicin cream",
"E": "Pregabalin"
} | [
"C"
] | nephrology | urinary system | [
"gabapentinoids"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-GPT-POS-001 | A 79-year-old woman with chronic kidney disease and several comorbidities has an estimated CrCl of 45 mL/min. Her physician is reviewing her medications for potential dose adjustments. | Which of the following medications requires dose reduction given this patient's renal function? Select all that apply. | {
"A": "Colchicine",
"B": "None of the above",
"C": "Amlodipine",
"D": "Cimetidine",
"E": "Levetiracetam"
} | [
"A",
"D",
"E"
] | nephrology | urinary system | [
"gabapentinoids"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-LEV-POS-001 | A 75-year-old woman with epilepsy on levetiracetam has an estimated CrCl of 55 mL/min. Her neurologist is reviewing her medications. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Phenytoin",
"C": "Lamotrigine",
"D": "Levetiracetam",
"E": "Valproic acid"
} | [
"D"
] | nephrology | urinary system | [
"antiepileptics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-NSA-NEG-001 | A 71-year-old man with osteoarthritis seeks oral analgesic options. His estimated CrCl is 48 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Ibuprofen",
"B": "Acetaminophen",
"C": "Celecoxib",
"D": "None of the above",
"E": "Naproxen"
} | [
"D"
] | nephrology | urinary system | [
"nsaids/antipyretic analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-NSA-POS-001 | A 77-year-old woman with chronic kidney disease has an estimated CrCl of 25 mL/min. Her physician is reviewing her current medications for agents that should be avoided. | Which of the following medications should be avoided given this patient's renal function? Select all that apply. | {
"A": "Losartan",
"B": "Amiloride",
"C": "Duloxetine",
"D": "None of the above",
"E": "Acetaminophen"
} | [
"B",
"C"
] | nephrology | urinary system | [
"nsaids/antipyretic analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TRA-POS-001 | A 76-year-old woman with moderate chronic pain has an estimated CrCl of 18 mL/min. Her physician is considering tramadol immediate-release for pain management. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Lidocaine patch",
"B": "Tramadol immediate-release",
"C": "Capsaicin cream",
"D": "None of the above",
"E": "Acetaminophen"
} | [
"B"
] | nephrology | urinary system | [
"opioid-like analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TRA-POS-002 | A 77-year-old man with chronic low back pain has an estimated CrCl of 18 mL/min. His physician is considering tramadol extended-release for pain management. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Tramadol extended-release",
"B": "None of the above",
"C": "Acetaminophen",
"D": "Lidocaine patch",
"E": "Capsaicin cream"
} | [
"A"
] | nephrology | urinary system | [
"opioid-like analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-H2B-POS-001 | An 80-year-old man with chronic kidney disease has an estimated CrCl of 22 mL/min. His physician is reviewing his current medications for agents that should be avoided. | Which of the following medications should be avoided given this patient's renal function? Select all that apply. | {
"A": "Triamterene",
"B": "Fondaparinux",
"C": "Lisinopril",
"D": "None of the above",
"E": "Warfarin"
} | [
"A",
"B"
] | nephrology | urinary system | [
"h2-receptor blockers"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-COL-POS-001 | A 75-year-old man with an acute gout flare has an estimated CrCl of 18 mL/min. His physician is selecting treatment. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Methylprednisolone",
"B": "Colchicine",
"C": "None of the above",
"D": "Febuxostat",
"E": "Prednisone"
} | [
"B"
] | nephrology | urinary system | [
"antigout agents"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-PRO-POS-001 | A 75-year-old woman with gout and chronic kidney disease has an estimated CrCl of 18 mL/min. Her physician is selecting urate-lowering therapy. Colchicine at this CrCl requires dose reduction but can be used. | Which of the following medications should be avoided (rather than dose-adjusted) given this patient's renal function? | {
"A": "Febuxostat",
"B": "Colchicine",
"C": "Probenecid",
"D": "None of the above",
"E": "Allopurinol"
} | [
"C"
] | nephrology | urinary system | [
"antigout agents"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-NIT-NEG-001 | A 70-year-old woman with recurrent urinary tract infections has a stable estimated CrCl of 60 mL/min. Her physician is selecting an antibiotic for prophylaxis or treatment. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Amoxicillin",
"B": "Cephalexin",
"C": "Fosfomycin",
"D": "None of the above",
"E": "Nitrofurantoin"
} | [
"D"
] | nephrology | urinary system | [
"urinary antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TMP-NEG-001 | A 71-year-old man with a bacterial infection requires antibiotic therapy. His estimated CrCl is 45 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Azithromycin",
"B": "Doxycycline",
"C": "None of the above",
"D": "Trimethoprim-sulfamethoxazole",
"E": "Amoxicillin"
} | [
"C"
] | nephrology | urinary system | [
"antibacterials"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DAB-NEG-001 | A 74-year-old man with nonvalvular atrial fibrillation requires long-term anticoagulation. His estimated CrCl is 55 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Heparin",
"B": "Dabigatran",
"C": "None of the above",
"D": "Apixaban",
"E": "Warfarin"
} | [
"C"
] | nephrology | urinary system | [
"direct thrombin inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-EDO-NEG-001 | A 71-year-old woman with deep vein thrombosis requires anticoagulation. Her estimated CrCl is 65 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Warfarin",
"C": "Edoxaban",
"D": "Heparin",
"E": "Apixaban"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-ENO-NEG-001 | A 70-year-old man with a pulmonary embolism requires bridging anticoagulation. His estimated CrCl is 48 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Apixaban",
"B": "None of the above",
"C": "Warfarin",
"D": "Unfractionated heparin",
"E": "Enoxaparin"
} | [
"B"
] | nephrology | urinary system | [
"low-molecular-weight heparin anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-FON-NEG-001 | A 72-year-old woman with a deep vein thrombosis is being evaluated for anticoagulation. Her estimated CrCl is 48 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Apixaban",
"B": "None of the above",
"C": "Warfarin",
"D": "Fondaparinux",
"E": "Enoxaparin"
} | [
"B"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-RIV-NEG-001 | A 73-year-old man with atrial fibrillation is being considered for rivaroxaban. His estimated CrCl is 65 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Dabigatran",
"C": "Rivaroxaban",
"D": "Warfarin",
"E": "Apixaban"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-DUL-NEG-001 | A 69-year-old woman with depression and generalized anxiety disorder has an estimated CrCl of 48 mL/min. Her psychiatrist is selecting an antidepressant. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Duloxetine",
"B": "Sertraline",
"C": "Escitalopram",
"D": "Venlafaxine",
"E": "None of the above"
} | [
"E"
] | nephrology | urinary system | [
"antidepressants/analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-LEV-NEG-001 | A 68-year-old man with epilepsy managed with levetiracetam has an estimated CrCl of 90 mL/min. His neurologist is reviewing his antiepileptic regimen. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Valproic acid",
"C": "Lamotrigine",
"D": "Levetiracetam",
"E": "Phenytoin"
} | [
"A"
] | nephrology | urinary system | [
"antiepileptics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TRA-NEG-001 | A 73-year-old man with moderate chronic back pain has an estimated CrCl of 48 mL/min. His physician is considering tramadol for pain management. | Which of the following medications requires dose reduction or avoidance given this patient's renal function? | {
"A": "Acetaminophen",
"B": "Tramadol",
"C": "None of the above",
"D": "Lidocaine patch",
"E": "Capsaicin cream"
} | [
"C"
] | nephrology | urinary system | [
"opioid-like analgesics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-H2B-NEG-001 | A 74-year-old man with GERD requiring acid suppression has an estimated CrCl of 65 mL/min. His physician is selecting a medication. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Famotidine",
"C": "Nizatidine",
"D": "Omeprazole",
"E": "Cimetidine"
} | [
"A"
] | nephrology | urinary system | [
"h2-receptor blockers"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-COL-NEG-001 | A 70-year-old man with a history of gout has an estimated CrCl of 48 mL/min. His physician is evaluating colchicine therapy for gout prophylaxis. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Probenecid",
"B": "Prednisone",
"C": "Febuxostat",
"D": "None of the above",
"E": "Colchicine"
} | [
"D"
] | nephrology | urinary system | [
"antigout agents"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-PRO-NEG-001 | A 71-year-old man with hyperuricemia and recurrent gout has an estimated CrCl of 48 mL/min. His physician is considering urate-lowering therapy. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Colchicine",
"B": "Febuxostat",
"C": "Probenecid",
"D": "None of the above",
"E": "Allopurinol"
} | [
"D"
] | nephrology | urinary system | [
"antigout agents"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-AMI-POS-001 | A 74-year-old man with hypertension and peripheral edema has been managed with amiloride. His estimated CrCl is 18 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "None of the above",
"B": "Furosemide",
"C": "Amlodipine",
"D": "Amiloride",
"E": "Metoprolol"
} | [
"D"
] | nephrology | urinary system | [
"antiarrhythmics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-SPI-POS-001 | A 76-year-old woman with heart failure with reduced ejection fraction is managed with spironolactone for aldosterone blockade. Her estimated CrCl is 18 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Sacubitril-valsartan",
"B": "Spironolactone",
"C": "None of the above",
"D": "Carvedilol",
"E": "Furosemide"
} | [
"B"
] | nephrology | urinary system | [
"aldosterone receptor antagonists"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-TRI-POS-001 | A 71-year-old man with hypertension and peripheral edema is prescribed triamterene for diuresis. His estimated CrCl is 18 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Metoprolol",
"B": "Triamterene",
"C": "Amlodipine",
"D": "None of the above",
"E": "Furosemide"
} | [
"B"
] | nephrology | urinary system | [
"potassium-sparing diuretics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-GAB-POS-001 | A 77-year-old woman with postherpetic neuralgia has an estimated CrCl of 35 mL/min. Her physician is considering gabapentin for neuropathic pain. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Gabapentin",
"B": "None of the above",
"C": "Amitriptyline",
"D": "Lamotrigine",
"E": "Lidocaine patch"
} | [
"A"
] | nephrology | urinary system | [
"gabapentinoids"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-PRE-POS-001 | A 73-year-old man with diabetic peripheral neuropathy has an estimated CrCl of 35 mL/min. His physician is considering pregabalin for pain management. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Pregabalin",
"C": "Capsaicin cream",
"D": "Duloxetine",
"E": "Amitriptyline"
} | [
"B"
] | nephrology | urinary system | [
"gabapentinoids"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-CIM-POS-001 | A 75-year-old man with GERD is managed with cimetidine. His estimated CrCl is 30 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "None of the above",
"B": "Omeprazole",
"C": "Pantoprazole",
"D": "Calcium carbonate",
"E": "Cimetidine"
} | [
"E"
] | nephrology | urinary system | [
"h2-receptor blockers"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-FAM-POS-001 | A 72-year-old woman with peptic ulcer disease is treated with famotidine. Her estimated CrCl is 30 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Omeprazole",
"B": "Sucralfate",
"C": "Misoprostol",
"D": "None of the above",
"E": "Famotidine"
} | [
"E"
] | nephrology | urinary system | [
"h2-receptor blockers"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-NIZ-POS-001 | A 69-year-old man with GERD is currently taking nizatidine. His estimated CrCl is 30 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Sucralfate",
"B": "Pantoprazole",
"C": "Nizatidine",
"D": "None of the above",
"E": "Calcium carbonate"
} | [
"C"
] | nephrology | urinary system | [
"h2-receptor blockers"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-AMI-NEG-001 | A 74-year-old man with hypertension managed with amiloride has an estimated CrCl of 48 mL/min. | Which of the following medications should be avoided given this patient's renal function? | {
"A": "Amiloride",
"B": "Furosemide",
"C": "Metoprolol",
"D": "None of the above",
"E": "Amlodipine"
} | [
"D"
] | nephrology | urinary system | [
"antiarrhythmics"
] | dose threshold | older adults | static risk identification | guideline_following |
RK-GAB-NEG-001 | A 70-year-old woman with chronic neuropathic pain managed with gabapentin has an estimated CrCl of 75 mL/min. | Which of the following medications requires dose reduction given this patient's renal function? | {
"A": "Duloxetine",
"B": "Amitriptyline",
"C": "None of the above",
"D": "Gabapentin",
"E": "Oxycodone"
} | [
"C"
] | nephrology | urinary system | [
"gabapentinoids"
] | dose threshold | older adults | static risk identification | guideline_following |
TS-RIV-001 | A 78-year-old man with non-valvular atrial fibrillation has an estimated CrCl of 10 mL/min. His physician is determining the appropriate rivaroxaban regimen for stroke prevention. | Which of the following rivaroxaban prescriptions is most appropriate given this patient's renal function? | {
"A": "Do not prescribe rivaroxaban in this patient",
"B": "Rivaroxaban 20 mg daily",
"C": "Rivaroxaban 15 mg daily",
"D": "None of the above",
"E": "Rivaroxaban 2.5 mg twice daily"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
TS-RIV-002 | A 78-year-old man with non-valvular atrial fibrillation has an estimated CrCl of 35 mL/min. His physician is determining the appropriate rivaroxaban regimen for stroke prevention. | Which of the following rivaroxaban prescriptions is most appropriate given this patient's renal function? | {
"A": "None of the above",
"B": "Rivaroxaban 15 mg daily",
"C": "Do not prescribe rivaroxaban in this patient",
"D": "Rivaroxaban 20 mg daily",
"E": "Rivaroxaban 2.5 mg twice daily"
} | [
"B"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
TS-RIV-003 | A 78-year-old man with non-valvular atrial fibrillation has an estimated CrCl of 60 mL/min. His physician is determining the appropriate rivaroxaban regimen for stroke prevention. | Which of the following rivaroxaban prescriptions is most appropriate given this patient's renal function? | {
"A": "Rivaroxaban 20 mg daily",
"B": "Rivaroxaban 15 mg daily",
"C": "None of the above",
"D": "Rivaroxaban 2.5 mg twice daily",
"E": "Do not prescribe rivaroxaban in this patient"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
TS-EDO-001 | A 74-year-old woman with venous thromboembolism has an estimated CrCl of 10 mL/min. Her physician is selecting an edoxaban regimen for anticoagulation. | Which of the following edoxaban prescriptions is most appropriate given this patient's renal function? | {
"A": "Edoxaban 15 mg daily",
"B": "Do not prescribe edoxaban in this patient",
"C": "Edoxaban 30 mg daily",
"D": "Edoxaban 60 mg daily",
"E": "None of the above"
} | [
"B"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
TS-EDO-002 | A 74-year-old woman with venous thromboembolism has an estimated CrCl of 35 mL/min. Her physician is selecting an edoxaban regimen for anticoagulation. | Which of the following edoxaban prescriptions is most appropriate given this patient's renal function? | {
"A": "Edoxaban 30 mg daily",
"B": "None of the above",
"C": "Edoxaban 15 mg daily",
"D": "Do not prescribe edoxaban in this patient",
"E": "Edoxaban 60 mg daily"
} | [
"A"
] | nephrology | urinary system | [
"factor xa inhibitors/anticoagulants"
] | dose threshold | older adults | static risk identification | guideline_following |
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