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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
C
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A
G
G
T
G
G
A
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C
A
G
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G
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T
G
C
T
G
T
C
A
T
T
A
T
C
C
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C
C
A
C
A
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A
T
C
C
C
T
A
G
C
A
A
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G
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A
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A
A
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C
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G
G
G
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C
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G
A
G
T
G
T
C
A
T
A
G
T
C
G
A
C
G
G
C
C
C
A
G
T
G
G
A
A
C
A
G
T
T
G
G
C
C
C
C
A
G
A
C
T
C
T
G
G
C
C
A
G
G
C
T
A
A
C
T
T
G
A
C
A
A
C
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0
33,884
G
T
T
C
G
G
C
C
C
C
A
G
T
G
C
C
T
T
A
G
C
C
C
A
G
G
G
G
A
A
T
G
C
T
C
C
T
C
C
T
T
G
A
G
A
T
G
A
T
G
A
G
G
T
G
A
C
C
T
G
C
A
G
A
A
T
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0
33,885
C
C
A
G
A
A
C
G
C
T
G
A
A
T
C
C
C
G
A
A
G
A
C
C
C
A
T
C
A
T
T
G
T
C
A
T
C
A
A
G
G
C
C
T
T
C
A
T
C
C
T
T
T
T
C
C
T
C
T
C
T
C
T
T
G
C
0.078278
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0.062622
0
33,886
T
A
A
T
G
T
C
A
C
A
A
G
A
G
A
G
A
G
G
A
A
A
A
G
G
A
T
G
A
A
G
G
C
C
T
T
G
A
T
G
A
C
A
A
T
G
A
T
G
G
G
T
C
T
T
C
G
G
G
A
T
T
C
A
G
G
0.078278
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0
33,887
G
T
A
C
C
C
C
A
G
G
A
A
G
C
C
C
A
G
G
G
G
T
T
C
C
C
C
T
C
C
A
C
C
G
C
T
C
C
C
T
T
T
C
A
A
A
A
T
C
A
C
C
T
A
T
G
C
A
A
A
A
T
A
A
G
T
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0
33,888
T
A
A
C
A
C
A
A
A
A
A
G
A
G
A
C
A
T
T
T
C
T
T
G
T
G
G
C
A
A
T
T
T
T
T
T
T
C
T
T
C
C
T
T
T
T
A
G
A
A
A
A
G
C
A
A
T
T
T
T
T
C
T
T
T
G
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0
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G
A
C
A
C
A
A
A
G
T
C
C
A
T
T
C
C
A
A
A
A
A
T
G
C
A
G
G
A
A
G
A
C
G
T
G
T
A
T
A
C
A
A
T
G
C
T
G
G
G
A
A
T
C
C
C
A
G
G
A
T
C
C
C
C
T
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0
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0
33,890
G
G
A
G
T
C
A
T
A
T
G
A
T
T
T
A
C
C
A
G
A
A
T
G
C
T
G
A
C
T
C
T
C
G
G
A
G
T
C
C
C
A
T
C
A
T
T
G
T
C
A
T
C
A
A
T
G
A
C
G
T
A
A
T
G
T
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0
33,891
T
C
A
T
T
C
T
A
A
T
A
G
A
T
G
A
A
C
T
T
T
T
T
C
C
A
G
C
A
C
C
A
T
T
G
G
G
T
C
C
T
A
G
C
A
A
T
C
C
C
A
A
A
A
T
T
T
C
A
C
C
T
G
A
A
C
0.129159
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0
0
0
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0
33,892
T
C
C
C
A
A
T
C
G
A
T
C
T
T
T
T
C
A
T
T
T
A
A
C
A
T
A
G
C
A
T
A
C
A
T
T
A
T
A
T
T
T
T
C
A
A
C
A
A
T
C
A
A
A
G
G
G
A
A
T
A
T
T
G
C
T
0.09589
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0.037182
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0.029354
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0.054795
0.003914
0.021526
0.011742
0.027397
0.02544
0.064579
0.035225
0
33,893
T
T
T
C
T
G
T
C
C
T
T
C
A
C
T
T
A
A
A
T
G
T
T
T
A
G
C
A
A
G
G
T
T
A
T
C
T
T
G
A
A
T
G
T
T
T
T
G
C
A
T
G
T
C
C
A
A
T
T
C
C
A
A
T
A
A
0.097847
0.029354
0.043053
0.058708
0.035225
0.02544
0.003914
0.027397
0.043053
0.021526
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0.048924
0.033268
0.062622
0.039139
0.023483
0.02544
0.041096
0.005871
0
0.007828
0.003914
0.019569
0.029354
0.043053
0.017613
0.035225
0.009785
0.031311
0.021526
0.048924
0.041096
0
33,894
T
A
T
A
A
T
T
T
G
G
G
T
G
A
A
T
G
T
T
A
T
G
A
T
A
A
T
T
G
T
A
A
C
G
A
A
T
A
T
G
G
A
A
A
T
A
A
T
A
A
A
G
A
T
G
A
A
G
C
C
A
G
C
A
T
T
0.072407
0.021526
0.050881
0.072407
0.048924
0.015656
0.003914
0.035225
0.039139
0.027397
0.019569
0.091977
0.027397
0.054795
0.033268
0.02544
0.015656
0.023483
0.009785
0
0.005871
0.001957
0.041096
0.013699
0.035225
0.015656
0.02544
0.011742
0.015656
0.037182
0.076321
0.031311
0
33,895
T
G
G
G
C
A
A
A
G
A
A
G
A
T
G
C
T
G
C
T
C
T
C
A
G
T
A
T
T
T
C
A
C
G
G
T
A
C
A
G
A
G
A
G
A
A
G
T
C
T
C
A
C
A
A
T
T
T
G
T
A
G
C
A
G
T
0.074364
0.027397
0.052838
0.058708
0.039139
0.017613
0.005871
0.033268
0.04501
0.033268
0.035225
0.046967
0.019569
0.039139
0.04501
0.023483
0.037182
0.023483
0.019569
0.001957
0
0
0.023483
0.031311
0.04501
0.015656
0.041096
0.019569
0.02544
0.029354
0.048924
0.041096
0
33,896
G
G
G
A
A
T
T
T
T
T
A
A
C
T
T
C
A
C
G
G
A
G
C
T
T
A
T
T
C
A
A
A
T
G
G
A
G
A
G
C
A
C
T
T
C
A
T
T
T
T
C
T
C
G
T
G
T
A
A
G
T
A
G
A
G
C
0.068493
0.023483
0.058708
0.078278
0.041096
0.009785
0.007828
0.041096
0.052838
0.023483
0.029354
0.064579
0.013699
0.027397
0.043053
0.023483
0.021526
0.017613
0.011742
0.001957
0.005871
0.003914
0.033268
0.033268
0.056751
0.007828
0.02544
0.015656
0.023483
0.04501
0.060665
0.029354
0
33,897
A
A
C
A
C
C
A
C
T
T
A
A
G
T
A
A
T
T
A
T
C
C
A
G
G
T
G
T
G
T
A
A
T
C
T
G
A
G
A
T
T
T
A
A
A
A
G
A
A
A
A
A
A
T
A
A
A
A
T
G
T
T
A
G
A
C
0.16047
0.033268
0.037182
0.091977
0.039139
0.017613
0
0.035225
0.037182
0.013699
0.011742
0.076321
0.029354
0.041096
0.02544
0.021526
0.017613
0.017613
0.007828
0
0.001957
0.001957
0.027397
0.017613
0.031311
0
0.019569
0.003914
0.007828
0.037182
0.105675
0.031311
0
33,898
T
C
A
C
T
G
C
A
T
T
C
A
T
C
T
T
A
C
C
T
T
T
T
C
T
G
A
A
T
G
C
A
T
C
A
C
A
T
T
T
A
A
A
G
C
C
G
C
A
C
T
A
T
G
G
G
G
A
G
C
C
A
C
G
G
C
0.113503
0.02544
0.039139
0.088063
0.027397
0.009785
0.011742
0.037182
0.043053
0.02544
0.005871
0.078278
0.033268
0.043053
0.023483
0.021526
0.027397
0.023483
0.007828
0.003914
0.005871
0.005871
0.029354
0.015656
0.041096
0.017613
0.019569
0.011742
0.011742
0.019569
0.088063
0.04501
0
33,899
C
C
A
C
A
T
T
T
T
C
A
C
C
C
T
T
C
T
T
T
C
T
G
T
A
T
G
T
C
T
T
C
T
G
A
A
T
A
C
C
A
C
T
A
A
T
T
C
T
G
A
A
A
T
A
T
A
A
A
G
T
T
T
T
A
C
0.11546
0.031311
0.041096
0.074364
0.043053
0.019569
0.001957
0.04501
0.035225
0.015656
0.019569
0.082192
0.009785
0.037182
0.035225
0.033268
0.02544
0.027397
0.007828
0
0.001957
0.007828
0.029354
0.019569
0.043053
0.009785
0.027397
0.015656
0.011742
0.033268
0.066536
0.033268
0
33,900
A
T
T
T
A
C
C
T
G
T
A
T
A
A
T
G
G
C
A
G
C
A
T
C
T
A
T
G
G
A
T
G
C
T
T
G
T
A
A
A
A
C
T
G
T
G
A
A
A
C
C
T
G
A
G
G
A
C
C
A
G
T
A
C
T
T
0.135029
0.027397
0.041096
0.064579
0.043053
0.019569
0.001957
0.033268
0.039139
0.019569
0.021526
0.07045
0.037182
0.043053
0.048924
0.007828
0.033268
0.02544
0.007828
0
0.001957
0
0.021526
0.015656
0.037182
0.011742
0.019569
0.011742
0.015656
0.050881
0.048924
0.04501
0
33,901
C
T
C
T
T
C
A
G
T
T
G
G
C
T
G
T
G
T
C
A
C
G
T
A
C
C
T
T
T
C
T
G
C
A
C
T
T
C
T
G
A
A
G
T
A
T
C
A
T
A
T
T
T
T
A
A
A
T
G
T
A
G
G
T
T
A
0.068493
0.041096
0.041096
0.056751
0.052838
0.027397
0.011742
0.033268
0.050881
0.021526
0.02544
0.046967
0.027397
0.041096
0.039139
0.037182
0.031311
0.021526
0.013699
0.001957
0.005871
0.003914
0.021526
0.035225
0.04501
0.017613
0.021526
0.007828
0.013699
0.029354
0.054795
0.052838
0
33,902
C
G
G
G
T
A
G
C
C
T
G
G
G
T
A
T
T
T
T
G
C
G
T
C
C
G
C
A
T
T
G
A
T
A
A
T
A
T
G
A
T
A
G
C
T
G
C
T
G
C
C
G
T
A
A
T
A
G
C
T
C
A
T
T
C
C
0.072407
0.029354
0.046967
0.04501
0.048924
0.023483
0.009785
0.02544
0.052838
0.050881
0.011742
0.050881
0.02544
0.037182
0.054795
0.035225
0.027397
0.041096
0.013699
0.005871
0.005871
0.009785
0.041096
0.02544
0.037182
0.019569
0.031311
0.019569
0.015656
0.023483
0.029354
0.033268
0
33,903
C
G
G
G
G
T
C
T
T
T
G
G
T
G
C
C
T
T
T
G
C
C
G
T
G
G
T
G
C
T
G
G
C
T
G
A
G
C
C
C
A
T
C
C
T
G
C
C
C
T
A
C
G
C
T
C
T
G
G
C
C
T
T
T
G
T
0.027397
0.017613
0.035225
0.007828
0.031311
0.027397
0.017613
0.015656
0.043053
0.043053
0.050881
0.011742
0.02544
0.056751
0.027397
0.035225
0.058708
0.062622
0.066536
0.015656
0.003914
0.005871
0.011742
0.043053
0.027397
0.029354
0.054795
0.052838
0.048924
0.009785
0.005871
0.029354
0
33,904
T
T
T
C
C
T
T
C
T
G
G
T
A
C
T
G
T
G
T
C
T
A
G
C
A
A
C
C
T
A
T
G
C
T
A
C
C
A
A
G
C
T
A
C
C
G
C
G
T
G
G
T
G
G
C
G
C
C
G
T
C
T
G
T
C
A
0.058708
0.021526
0.046967
0.041096
0.054795
0.029354
0.003914
0.02544
0.04501
0.041096
0.035225
0.046967
0.02544
0.027397
0.037182
0.041096
0.046967
0.037182
0.011742
0.011742
0.007828
0.013699
0.031311
0.021526
0.039139
0.021526
0.033268
0.02544
0.029354
0.029354
0.033268
0.02544
0
33,905
A
G
C
C
G
G
C
A
C
T
T
T
C
A
A
A
T
T
C
C
A
C
T
G
T
C
T
C
T
T
T
G
T
A
A
G
G
T
G
A
G
G
C
T
G
T
G
T
A
G
T
G
T
G
G
C
A
G
G
A
T
G
A
G
C
C
0.056751
0.017613
0.050881
0.029354
0.056751
0.029354
0.003914
0.029354
0.046967
0.035225
0.037182
0.031311
0.027397
0.02544
0.043053
0.048924
0.046967
0.039139
0.017613
0.013699
0.007828
0.013699
0.029354
0.023483
0.041096
0.027397
0.037182
0.027397
0.033268
0.02544
0.015656
0.031311
0
33,906
A
T
G
T
A
A
G
A
T
G
T
G
C
C
T
T
T
C
G
C
T
T
T
C
T
G
C
C
A
T
G
A
C
T
G
T
G
A
G
G
C
C
T
C
C
C
C
A
G
C
C
A
T
G
T
G
G
A
A
C
T
G
T
G
A
T
0.060665
0.027397
0.031311
0.04501
0.046967
0.027397
0.001957
0.029354
0.043053
0.035225
0.02544
0.029354
0.029354
0.048924
0.023483
0.043053
0.043053
0.046967
0.054795
0.005871
0.005871
0.005871
0.021526
0.037182
0.027397
0.021526
0.027397
0.021526
0.029354
0.015656
0.050881
0.037182
0
33,907
T
T
G
A
T
C
T
G
G
G
C
A
G
C
C
A
T
G
C
T
G
T
A
G
A
A
C
T
T
C
T
C
C
T
G
G
G
A
T
G
G
C
T
G
C
T
G
T
G
G
C
T
G
C
A
G
G
G
G
A
A
G
G
C
A
T
0.033268
0.027397
0.043053
0.015656
0.035225
0.017613
0.011742
0.035225
0.056751
0.062622
0.031311
0.011742
0.033268
0.017613
0.021526
0.035225
0.07045
0.050881
0.029354
0.021526
0.009785
0.011742
0.02544
0.046967
0.046967
0.009785
0.039139
0.035225
0.048924
0.027397
0.017613
0.019569
0
33,908
C
T
T
A
T
T
T
G
A
A
G
G
G
G
A
G
T
T
G
C
T
G
G
T
G
C
T
G
C
T
T
T
C
A
A
G
T
T
C
C
T
G
C
A
A
A
G
C
T
G
A
A
A
C
C
A
A
G
A
G
C
T
C
C
T
G
0.046967
0.031311
0.058708
0.027397
0.029354
0.029354
0.001957
0.031311
0.052838
0.043053
0.041096
0.007828
0.02544
0.04501
0.039139
0.019569
0.046967
0.04501
0.023483
0.011742
0.005871
0.007828
0.019569
0.043053
0.050881
0.023483
0.029354
0.033268
0.035225
0.019569
0.027397
0.046967
0
33,909
G
G
G
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
T
C
A
A
T
A
G
C
C
C
G
G
A
C
A
G
G
G
C
C
A
G
C
G
G
G
C
C
G
G
A
A
G
G
C
A
G
C
0.031311
0.023483
0.046967
0.013699
0.04501
0.017613
0.009785
0.027397
0.033268
0.064579
0.048924
0.017613
0.019569
0.023483
0.02544
0.033268
0.078278
0.035225
0.029354
0.027397
0.003914
0.021526
0.011742
0.037182
0.037182
0.021526
0.037182
0.058708
0.035225
0.021526
0.019569
0.043053
0
33,910
A
G
T
C
T
C
A
A
G
G
G
G
A
A
A
G
A
C
C
A
C
A
T
T
T
A
A
G
T
T
T
G
T
T
C
A
T
T
C
C
G
A
G
G
G
A
G
A
C
G
A
C
T
T
A
C
C
A
G
T
T
T
C
A
T
C
0.056751
0.02544
0.052838
0.031311
0.04501
0.011742
0.009785
0.041096
0.058708
0.031311
0.035225
0.009785
0.021526
0.043053
0.029354
0.027397
0.050881
0.035225
0.031311
0.005871
0.007828
0.003914
0.013699
0.048924
0.050881
0.037182
0.023483
0.019569
0.04501
0.017613
0.029354
0.048924
0
33,911
A
A
G
A
A
A
A
G
A
A
A
G
C
A
G
A
A
G
C
C
C
A
G
A
A
T
C
A
T
C
A
T
T
G
T
G
T
C
C
C
T
G
A
T
G
T
A
A
A
G
G
C
A
T
T
A
A
T
G
G
A
G
A
G
T
C
0.037182
0.027397
0.04501
0.023483
0.039139
0.017613
0.005871
0.041096
0.052838
0.043053
0.037182
0.011742
0.021526
0.041096
0.029354
0.027397
0.068493
0.043053
0.037182
0.005871
0.009785
0.005871
0.015656
0.043053
0.050881
0.035225
0.039139
0.02544
0.043053
0.013699
0.017613
0.04501
0
33,912
G
G
G
C
T
C
T
G
G
C
A
C
C
C
A
G
T
G
T
G
T
G
A
T
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C
T
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G
A
A
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A
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A
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G
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C
C
A
G
A
G
A
T
A
A
C
T
G
G
0.029354
0.02544
0.048924
0.02544
0.037182
0.021526
0.003914
0.043053
0.048924
0.041096
0.039139
0.011742
0.023483
0.033268
0.035225
0.031311
0.064579
0.046967
0.048924
0.003914
0.009785
0.005871
0.015656
0.043053
0.04501
0.035225
0.033268
0.02544
0.043053
0.013699
0.019569
0.046967
0
33,913
C
A
T
T
A
G
A
G
A
G
A
A
G
T
T
G
G
A
G
G
T
T
G
T
A
A
G
T
C
C
G
G
C
A
G
G
G
G
G
T
T
C
C
A
A
A
C
T
C
C
T
T
A
T
A
T
G
A
G
T
T
G
A
G
C
T
0.084149
0.056751
0.050881
0.035225
0.050881
0.021526
0.007828
0.031311
0.037182
0.037182
0.039139
0.015656
0.009785
0.031311
0.054795
0.019569
0.037182
0.035225
0.021526
0.011742
0.007828
0
0.021526
0.035225
0.050881
0.021526
0.027397
0.021526
0.043053
0.015656
0.037182
0.029354
0
33,914
G
G
A
G
C
T
G
C
T
C
T
A
T
G
A
A
G
G
A
C
T
G
A
G
G
G
G
C
T
T
C
A
C
G
C
T
T
C
G
A
G
G
C
A
T
C
A
A
C
A
A
C
C
C
A
G
G
G
G
C
C
A
C
A
T
T
0.02544
0.013699
0.031311
0.02544
0.021526
0.033268
0.003914
0.021526
0.029354
0.043053
0.060665
0.017613
0.02544
0.04501
0.017613
0.041096
0.048924
0.054795
0.072407
0.017613
0.007828
0.009785
0.009785
0.066536
0.033268
0.013699
0.035225
0.041096
0.058708
0.011742
0.019569
0.043053
0
33,915
G
G
C
A
G
A
A
G
A
G
A
G
G
T
C
A
G
A
T
C
A
C
T
C
G
C
C
C
A
A
G
T
T
C
T
C
C
C
G
T
A
T
C
C
T
C
C
C
A
C
G
T
G
C
T
T
T
C
A
T
G
A
A
C
A
C
0.017613
0.029354
0.02544
0.013699
0.054795
0.033268
0.019569
0.021526
0.04501
0.033268
0.04501
0.005871
0.027397
0.019569
0.02544
0.060665
0.064579
0.052838
0.062622
0.027397
0.009785
0.013699
0.007828
0.046967
0.033268
0.027397
0.035225
0.039139
0.050881
0.011742
0.009785
0.029354
0
33,916
G
G
G
C
A
G
A
A
G
A
G
A
G
G
T
C
A
G
A
T
C
A
C
T
C
G
C
C
C
A
A
G
T
T
C
T
C
C
C
G
T
A
T
C
C
T
C
C
C
A
C
G
T
G
C
T
T
T
C
A
T
G
A
A
C
G
0.017613
0.029354
0.02544
0.013699
0.054795
0.033268
0.019569
0.021526
0.04501
0.033268
0.04501
0.005871
0.027397
0.019569
0.02544
0.060665
0.064579
0.050881
0.062622
0.027397
0.009785
0.013699
0.007828
0.046967
0.033268
0.027397
0.035225
0.041096
0.050881
0.011742
0.009785
0.029354
0
33,917
G
G
T
G
T
G
C
G
G
A
G
T
G
A
C
C
C
A
C
G
A
C
C
C
C
C
G
A
G
T
A
A
C
C
A
T
C
A
G
G
T
A
C
T
G
G
C
T
C
T
G
C
T
G
T
T
G
A
C
T
C
C
A
G
G
A
0.02544
0.019569
0.031311
0.021526
0.027397
0.041096
0.007828
0.027397
0.033268
0.054795
0.04501
0.015656
0.013699
0.031311
0.023483
0.043053
0.058708
0.062622
0.078278
0.013699
0.007828
0.009785
0.011742
0.058708
0.027397
0.017613
0.029354
0.039139
0.041096
0.023483
0.021526
0.037182
0
33,918
C
C
A
C
A
C
G
G
G
C
A
G
T
C
C
T
G
A
G
A
G
C
T
G
A
A
C
A
A
C
A
A
C
G
C
T
G
C
C
C
G
C
C
A
T
C
T
G
C
T
G
T
A
T
G
A
A
C
T
T
C
A
G
G
G
T
0.046967
0.023483
0.031311
0.009785
0.02544
0.039139
0.009785
0.019569
0.041096
0.056751
0.054795
0.009785
0.023483
0.027397
0.02544
0.02544
0.074364
0.048924
0.041096
0.027397
0.005871
0.011742
0.019569
0.046967
0.027397
0.023483
0.048924
0.046967
0.043053
0.021526
0.011742
0.031311
0
33,919
T
C
C
T
C
A
G
T
T
G
G
G
C
A
T
C
C
C
T
G
G
C
C
G
C
T
G
A
T
G
G
C
T
C
T
G
C
G
G
C
A
G
T
G
G
T
G
A
G
T
T
G
G
G
G
G
A
G
G
G
A
G
T
G
G
G
0.011742
0.019569
0.027397
0.005871
0.017613
0.043053
0.013699
0.023483
0.043053
0.035225
0.068493
0.003914
0.021526
0.023483
0.023483
0.039139
0.074364
0.07045
0.082192
0.013699
0.003914
0.011742
0.017613
0.054795
0.021526
0.033268
0.039139
0.058708
0.050881
0.005871
0.007828
0.033268
0
33,920
T
G
C
A
G
G
G
C
C
A
A
G
G
G
C
C
T
G
G
A
A
G
C
A
C
T
T
C
A
C
C
A
C
C
A
G
G
T
G
G
G
C
T
G
C
C
T
A
G
T
A
A
G
G
A
G
G
G
G
A
G
C
C
T
C
T
0.005871
0.007828
0.039139
0.005871
0.019569
0.023483
0.007828
0.017613
0.046967
0.064579
0.078278
0.003914
0.013699
0.011742
0.017613
0.027397
0.082192
0.062622
0.076321
0.017613
0.011742
0.009785
0.015656
0.07045
0.027397
0.023483
0.039139
0.078278
0.056751
0.011742
0.007828
0.017613
0
33,921
C
C
A
T
C
T
T
C
T
A
C
C
C
A
T
T
G
T
T
C
T
A
G
A
A
A
C
A
G
A
G
A
C
T
A
C
G
A
T
G
A
C
A
T
T
G
A
T
G
A
T
G
A
T
G
A
C
C
C
C
T
T
T
A
A
A
0.009785
0.011742
0.02544
0.007828
0.041096
0.035225
0.015656
0.021526
0.037182
0.046967
0.050881
0
0.015656
0.039139
0.011742
0.043053
0.074364
0.062622
0.076321
0.027397
0.009785
0.021526
0.017613
0.037182
0.027397
0.039139
0.037182
0.058708
0.04501
0.019569
0.005871
0.027397
0
33,922
C
C
C
A
C
C
G
G
C
C
C
C
T
T
C
C
C
T
A
T
C
T
C
C
A
C
A
G
G
T
C
C
T
G
C
C
A
G
G
A
C
A
G
C
T
C
C
A
G
G
T
T
C
T
C
A
A
T
C
T
G
G
T
T
G
C
0.029354
0.023483
0.017613
0.029354
0.031311
0.035225
0.011742
0.019569
0.021526
0.048924
0.046967
0.011742
0.029354
0.027397
0.029354
0.037182
0.064579
0.052838
0.056751
0.029354
0.023483
0.017613
0.013699
0.043053
0.02544
0.023483
0.050881
0.043053
0.050881
0.013699
0.015656
0.02544
0
33,923
C
C
C
C
A
G
G
C
A
C
C
C
G
G
T
G
C
T
T
A
C
G
G
A
A
G
A
G
G
C
T
A
C
G
T
T
C
T
T
C
T
C
A
T
T
C
C
T
C
T
G
G
A
G
G
G
T
A
G
A
G
A
G
C
C
T
0.027397
0.017613
0.023483
0.021526
0.033268
0.035225
0.017613
0.021526
0.039139
0.039139
0.062622
0.013699
0.011742
0.019569
0.023483
0.046967
0.058708
0.052838
0.072407
0.019569
0.007828
0.009785
0.023483
0.054795
0.023483
0.029354
0.035225
0.056751
0.04501
0.013699
0.015656
0.027397
0
33,924
T
A
T
G
G
C
G
T
C
T
G
C
C
T
C
C
T
T
C
T
T
C
T
T
C
A
G
C
T
C
T
G
C
G
A
A
G
A
T
G
A
T
G
T
C
G
A
A
G
A
A
C
T
C
C
T
C
C
T
C
G
G
C
C
T
T
0.009785
0.011742
0.054795
0.011742
0.015656
0.033268
0.007828
0.023483
0.052838
0.039139
0.064579
0.005871
0.023483
0.021526
0.02544
0.02544
0.062622
0.054795
0.060665
0.02544
0.015656
0.021526
0.009785
0.052838
0.037182
0.033268
0.039139
0.056751
0.052838
0.009785
0.015656
0.02544
0
33,925
A
C
C
C
A
G
A
C
A
G
G
C
A
A
T
G
T
C
T
T
T
T
C
T
T
C
C
T
C
T
C
T
C
C
G
C
T
G
G
T
A
C
A
A
A
A
G
A
G
G
G
C
C
T
G
G
A
A
G
A
T
G
A
C
C
T
0.058708
0.013699
0.050881
0.02544
0.033268
0.033268
0.011742
0.015656
0.048924
0.046967
0.046967
0.023483
0.021526
0.035225
0.027397
0.035225
0.058708
0.050881
0.039139
0.005871
0.003914
0.013699
0.013699
0.035225
0.033268
0.029354
0.035225
0.041096
0.031311
0.015656
0.029354
0.035225
0
33,926
T
G
A
G
T
G
C
A
G
G
G
A
C
A
G
G
C
T
G
C
T
G
C
G
C
T
C
T
G
T
C
G
C
G
G
G
T
G
C
C
A
G
C
A
G
G
T
G
T
C
G
C
C
C
C
T
C
G
G
T
T
C
C
C
A
T
0.017613
0.015656
0.027397
0.003914
0.027397
0.027397
0.015656
0.021526
0.031311
0.037182
0.058708
0.003914
0.015656
0.023483
0.021526
0.037182
0.07045
0.054795
0.072407
0.039139
0.021526
0.043053
0.009785
0.043053
0.023483
0.031311
0.050881
0.084149
0.041096
0.007828
0.001957
0.019569
0
33,927
C
C
T
C
G
C
T
C
A
G
T
G
A
G
T
G
C
A
G
G
G
A
C
A
G
G
C
T
G
C
T
G
C
G
C
T
C
T
G
T
C
G
C
G
G
G
T
G
C
C
A
G
C
A
G
G
T
G
T
C
G
C
C
C
C
T
0.015656
0.015656
0.029354
0.001957
0.027397
0.027397
0.015656
0.021526
0.031311
0.039139
0.062622
0.003914
0.015656
0.021526
0.021526
0.037182
0.07045
0.052838
0.07045
0.039139
0.021526
0.04501
0.009785
0.04501
0.023483
0.031311
0.050881
0.080235
0.043053
0.007828
0.001957
0.019569
0
33,928
C
G
T
G
G
G
G
C
A
G
G
C
G
G
G
G
C
C
C
A
C
G
G
G
T
A
G
C
C
C
G
T
C
G
A
G
A
A
C
C
A
C
C
A
C
C
T
G
G
G
T
T
G
G
G
G
G
G
A
A
C
A
G
C
C
T
0.009785
0.023483
0.021526
0.009785
0.009785
0.039139
0.005871
0.02544
0.041096
0.033268
0.062622
0.003914
0.019569
0.041096
0.019569
0.033268
0.072407
0.074364
0.101761
0.017613
0.005871
0.005871
0.013699
0.054795
0.031311
0.017613
0.056751
0.062622
0.050881
0.005871
0.003914
0.02544
0
33,929
C
C
T
C
A
A
C
C
T
C
G
A
C
A
A
C
G
G
G
A
T
C
A
T
G
A
A
A
G
T
C
T
C
G
G
A
G
C
C
A
T
G
G
T
G
T
A
T
C
C
A
C
C
C
C
A
C
A
C
C
A
G
T
A
G
T
0.019569
0.019569
0.023483
0.017613
0.062622
0.037182
0.013699
0.023483
0.043053
0.021526
0.064579
0.011742
0.02544
0.019569
0.023483
0.066536
0.066536
0.039139
0.064579
0.015656
0.007828
0.005871
0.009785
0.052838
0.033268
0.041096
0.029354
0.02544
0.056751
0.009785
0.003914
0.04501
0
33,930
T
A
A
A
C
A
A
C
A
T
A
C
C
C
T
T
T
G
G
A
A
A
T
C
C
A
T
A
T
G
C
A
T
G
T
A
T
G
T
G
G
C
A
A
A
T
C
C
C
T
T
A
A
A
A
C
A
A
G
A
T
G
A
T
G
C
0.09002
0.02544
0.037182
0.033268
0.041096
0.023483
0
0.027397
0.046967
0.037182
0.039139
0.035225
0.037182
0.043053
0.033268
0.029354
0.048924
0.039139
0.019569
0.003914
0.007828
0.005871
0.021526
0.043053
0.031311
0.013699
0.037182
0.02544
0.033268
0.021526
0.031311
0.037182
0
33,931
A
C
A
G
A
T
T
C
T
C
C
G
A
T
G
T
G
A
C
A
A
G
A
T
T
G
T
G
G
A
G
A
C
C
A
A
A
G
G
G
T
C
A
G
C
A
G
G
G
A
A
A
A
G
G
A
A
T
G
G
C
C
G
A
G
T
0.029354
0.009785
0.021526
0.023483
0.04501
0.04501
0.011742
0.015656
0.035225
0.02544
0.068493
0.007828
0.021526
0.02544
0.021526
0.058708
0.064579
0.050881
0.062622
0.021526
0.011742
0.009785
0.009785
0.048924
0.033268
0.041096
0.027397
0.04501
0.050881
0.007828
0.001957
0.046967
0
33,932
G
G
A
G
A
G
G
A
G
A
C
A
G
G
A
C
C
A
T
G
T
G
G
C
T
G
T
C
C
C
C
A
T
C
T
C
T
G
C
T
G
C
T
T
C
T
C
A
T
C
C
T
C
C
C
A
G
G
T
G
A
G
T
G
T
G
0.048924
0.031311
0.050881
0.023483
0.072407
0.021526
0.001957
0.02544
0.054795
0.039139
0.041096
0.017613
0.023483
0.041096
0.04501
0.041096
0.048924
0.035225
0.015656
0.005871
0.005871
0.009785
0.015656
0.04501
0.041096
0.031311
0.031311
0.017613
0.043053
0.017613
0.019569
0.037182
0
33,933
C
A
C
T
T
T
G
G
G
A
A
G
A
C
C
A
C
A
G
T
G
C
A
C
A
G
G
A
C
T
C
A
C
A
C
C
C
A
G
C
C
T
T
G
C
T
G
G
A
G
A
A
A
G
C
C
C
A
T
G
C
C
C
C
A
T
0.037182
0.011742
0.048924
0.015656
0.031311
0.017613
0.009785
0.037182
0.037182
0.039139
0.064579
0.001957
0.015656
0.029354
0.031311
0.046967
0.062622
0.052838
0.050881
0.009785
0.001957
0.001957
0.007828
0.058708
0.039139
0.02544
0.050881
0.04501
0.064579
0.011742
0.005871
0.035225
0
33,934
T
G
C
T
T
A
C
C
C
T
G
A
A
T
T
T
T
G
G
G
T
C
A
A
C
A
C
C
T
C
C
C
C
G
G
T
G
C
T
G
A
G
G
T
T
T
C
G
C
C
C
A
G
G
G
T
T
C
A
C
C
A
C
C
A
T
0.02544
0.021526
0.02544
0.015656
0.033268
0.048924
0.011742
0.013699
0.039139
0.037182
0.054795
0.011742
0.033268
0.037182
0.019569
0.054795
0.068493
0.064579
0.07045
0.009785
0.007828
0.009785
0.003914
0.046967
0.037182
0.019569
0.035225
0.035225
0.04501
0.011742
0.003914
0.046967
0
33,935
C
A
T
G
A
A
T
T
T
G
T
G
T
T
T
T
C
C
A
G
G
C
T
A
C
T
C
C
A
T
T
G
T
C
A
C
T
C
A
A
A
T
C
A
C
C
G
G
T
C
C
A
A
C
A
A
C
A
G
T
G
A
A
T
G
C
0.064579
0.031311
0.039139
0.033268
0.046967
0.037182
0.009785
0.029354
0.021526
0.037182
0.039139
0.017613
0.027397
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0.048924
0.052838
0.048924
0.048924
0.035225
0.017613
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0.009785
0.029354
0.035225
0.033268
0.02544
0.019569
0.048924
0.007828
0.019569
0.050881
0
33,936
C
G
C
T
G
A
C
C
C
T
G
G
A
G
C
A
G
G
A
G
T
A
T
G
C
C
A
T
G
C
A
G
T
G
C
A
G
C
T
G
G
C
A
G
G
A
A
G
A
T
G
C
A
G
A
C
A
G
T
G
A
G
G
A
G
C
0.021526
0.011742
0.04501
0.009785
0.029354
0.029354
0.007828
0.029354
0.041096
0.050881
0.062622
0.013699
0.011742
0.031311
0.017613
0.031311
0.078278
0.056751
0.064579
0.009785
0.005871
0.003914
0.015656
0.046967
0.039139
0.037182
0.039139
0.04501
0.054795
0.015656
0.009785
0.033268
0
33,937
A
G
C
C
A
T
G
G
C
C
T
C
T
A
T
C
A
C
A
A
A
G
G
T
G
G
T
G
G
T
C
A
C
G
A
A
G
C
T
G
A
G
G
G
G
G
C
C
G
A
G
T
G
C
C
C
A
G
C
G
C
C
A
A
A
T
0.037182
0.023483
0.035225
0.015656
0.031311
0.043053
0.019569
0.017613
0.060665
0.046967
0.041096
0.011742
0.009785
0.029354
0.021526
0.048924
0.052838
0.060665
0.035225
0.021526
0.009785
0.015656
0.015656
0.062622
0.033268
0.027397
0.037182
0.041096
0.037182
0.011742
0.019569
0.02544
0
33,938
G
A
G
A
C
A
G
A
C
A
G
A
C
A
C
G
G
A
C
A
A
A
G
A
G
A
A
A
G
A
G
A
C
A
G
A
G
G
T
T
A
G
T
T
G
A
G
C
A
T
C
C
C
A
A
G
G
G
C
A
T
C
C
C
A
T
0.021526
0.02544
0.035225
0.003914
0.041096
0.02544
0.005871
0.031311
0.084149
0.023483
0.054795
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0.019569
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0.019569
0.029354
0.064579
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0.066536
0.023483
0.007828
0.005871
0.017613
0.074364
0.037182
0.043053
0.029354
0.039139
0.054795
0.005871
0.007828
0.027397
0
33,939
C
A
C
T
C
A
C
C
A
G
C
A
C
C
A
C
A
G
C
G
T
G
G
T
A
G
G
C
C
T
C
C
T
G
C
A
G
C
T
C
C
G
G
C
A
C
C
G
T
C
A
C
G
T
C
C
C
T
G
C
C
C
A
C
C
C
0.003914
0.005871
0.02544
0.007828
0.019569
0.039139
0.017613
0.009785
0.027397
0.058708
0.07045
0.001957
0.013699
0.027397
0.009785
0.046967
0.086106
0.064579
0.086106
0.033268
0.005871
0.005871
0.011742
0.043053
0.023483
0.02544
0.058708
0.084149
0.046967
0.007828
0.005871
0.02544
0
33,940
A
A
A
A
C
A
C
A
C
T
C
A
C
T
T
T
T
A
T
C
T
T
G
C
T
G
A
T
A
C
T
G
T
G
G
C
C
T
G
G
G
G
A
A
C
T
G
C
T
G
A
G
C
C
A
G
T
G
T
C
T
T
G
C
A
C
0.035225
0.017613
0.035225
0.013699
0.029354
0.033268
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0.021526
0.033268
0.04501
0.068493
0.015656
0.02544
0.011742
0.027397
0.04501
0.058708
0.056751
0.080235
0.015656
0.015656
0.007828
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0.058708
0.02544
0.015656
0.031311
0.056751
0.052838
0.009785
0.013699
0.023483
0
33,941
G
A
G
A
G
A
A
A
T
G
C
C
T
C
A
C
C
A
G
C
C
A
G
G
A
C
T
T
C
T
G
C
C
G
G
G
G
C
C
G
G
G
T
G
G
C
G
G
C
C
G
C
T
C
T
C
T
C
C
T
C
G
G
C
C
T
0.005871
0.021526
0.033268
0.007828
0.027397
0.043053
0.011742
0.017613
0.046967
0.046967
0.050881
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0.013699
0.023483
0.017613
0.046967
0.07045
0.064579
0.056751
0.039139
0.007828
0.023483
0.013699
0.04501
0.037182
0.027397
0.041096
0.072407
0.041096
0.003914
0.007828
0.027397
0
33,942
C
G
T
G
G
G
G
A
T
C
T
T
G
G
T
A
G
A
G
C
A
C
G
G
C
G
T
G
T
G
G
T
C
G
G
C
G
G
G
T
G
G
T
G
C
T
T
G
C
C
A
C
A
T
A
G
T
A
G
A
G
A
A
G
C
T
0.003914
0.015656
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0.031311
0.041096
0.017613
0.015656
0.04501
0.04501
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0.021526
0.056751
0.064579
0.056751
0.068493
0.046967
0.009785
0.031311
0.011742
0.041096
0.031311
0.02544
0.050881
0.072407
0.035225
0.005871
0
0.027397
0
33,943
T
C
C
G
C
T
G
C
A
A
G
T
C
A
C
A
G
C
T
G
G
A
C
C
T
T
G
T
C
T
T
C
T
C
T
G
T
C
A
T
C
G
A
G
A
T
G
G
T
C
T
T
C
A
T
C
G
G
C
G
T
C
C
A
G
C
0.003914
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0.023483
0.005871
0.068493
0.052838
0.023483
0.013699
0.031311
0.027397
0.04501
0.009785
0.021526
0.037182
0.019569
0.09002
0.039139
0.048924
0.068493
0.037182
0.017613
0.023483
0.023483
0.031311
0.021526
0.035225
0.043053
0.043053
0.035225
0.015656
0.001957
0.02544
0
33,944
C
C
C
G
G
C
C
G
C
G
G
G
G
A
C
G
A
C
T
T
G
G
G
C
G
C
C
C
A
G
G
A
C
G
G
G
G
T
C
T
C
C
T
C
A
C
C
G
G
C
A
G
C
C
T
C
T
C
C
A
G
G
C
C
A
A
0.001957
0.005871
0.015656
0
0.015656
0.029354
0.035225
0.021526
0.015656
0.068493
0.046967
0
0.011742
0.011742
0.017613
0.048924
0.074364
0.048924
0.04501
0.056751
0.029354
0.072407
0.003914
0.058708
0.003914
0.027397
0.074364
0.082192
0.043053
0.019569
0
0.013699
0
33,945
G
G
G
G
C
A
T
C
C
T
C
T
G
C
T
G
C
C
G
A
C
G
C
T
G
C
C
A
C
G
G
C
C
T
C
A
C
T
G
C
C
A
A
T
G
T
G
G
C
T
G
C
T
G
C
C
T
G
G
G
G
A
G
G
G
T
0.003914
0.007828
0.02544
0.009785
0.019569
0.041096
0.017613
0.009785
0.031311
0.04501
0.076321
0.003914
0.015656
0.029354
0.015656
0.054795
0.082192
0.09002
0.066536
0.013699
0.007828
0.011742
0.005871
0.050881
0.02544
0.017613
0.048924
0.09002
0.048924
0.007828
0.001957
0.023483
0
33,946
A
G
A
A
A
A
A
G
A
T
T
A
T
T
T
T
C
T
C
A
C
C
G
T
T
C
T
G
G
A
G
G
C
T
A
G
G
A
A
G
T
C
C
A
G
G
A
T
C
A
G
G
G
C
A
C
T
G
G
C
A
A
T
G
T
T
0.041096
0.027397
0.046967
0.031311
0.035225
0.037182
0.005871
0.02544
0.048924
0.017613
0.064579
0.027397
0.039139
0.031311
0.037182
0.043053
0.039139
0.043053
0.035225
0.001957
0.001957
0.005871
0.027397
0.043053
0.033268
0.013699
0.027397
0.035225
0.035225
0.019569
0.035225
0.043053
0
33,947
T
A
T
T
T
G
T
G
T
C
T
T
G
T
C
C
T
T
A
G
A
G
A
G
C
T
A
G
G
C
C
C
T
G
G
A
G
G
T
A
A
C
G
G
G
A
T
G
A
C
C
A
A
A
C
A
G
G
C
C
A
C
A
G
G
C
0.043053
0.027397
0.029354
0.017613
0.050881
0.021526
0.017613
0.02544
0.035225
0.043053
0.043053
0.007828
0.02544
0.039139
0.029354
0.048924
0.054795
0.052838
0.041096
0.019569
0.007828
0.013699
0.017613
0.043053
0.031311
0.027397
0.029354
0.046967
0.04501
0.011742
0.013699
0.039139
0
33,948
C
A
T
G
C
G
C
T
G
C
C
C
A
T
T
C
A
T
T
T
T
C
T
C
C
A
G
C
T
G
C
T
C
C
C
C
A
A
C
C
C
G
G
T
G
C
A
G
C
T
G
C
A
G
C
A
C
C
A
A
A
C
A
G
T
T
0.021526
0.015656
0.039139
0.013699
0.033268
0.023483
0.001957
0.039139
0.029354
0.066536
0.043053
0.001957
0.021526
0.02544
0.027397
0.04501
0.082192
0.064579
0.039139
0.023483
0.005871
0.011742
0.009785
0.046967
0.029354
0.015656
0.054795
0.058708
0.048924
0.019569
0.011742
0.029354
0
33,949
T
C
G
C
G
G
T
C
G
C
A
G
A
A
G
C
T
G
C
C
C
C
A
G
C
G
C
T
C
G
C
A
T
G
G
C
C
C
C
A
A
G
G
A
C
T
T
T
C
T
G
C
C
C
G
A
C
G
G
C
T
C
G
G
C
G
0.003914
0.005871
0.021526
0.001957
0.003914
0.02544
0.013699
0.011742
0.023483
0.062622
0.035225
0
0.003914
0.009785
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0.023483
0.052838
0.041096
0.113503
0.099804
0.029354
0.111546
0.001957
0.056751
0.021526
0.021526
0.033268
0.109589
0.041096
0.003914
0.001957
0.009785
0
33,950
A
C
C
A
T
G
G
G
C
T
T
C
T
C
A
G
A
G
C
A
G
G
G
C
C
G
G
C
A
G
C
G
C
C
T
T
C
A
C
C
C
G
G
A
A
G
A
G
G
C
C
T
T
G
T
A
T
C
T
T
C
T
G
G
A
G
0.021526
0.019569
0.041096
0.011742
0.02544
0.031311
0.013699
0.027397
0.041096
0.031311
0.050881
0.005871
0.011742
0.013699
0.02544
0.04501
0.048924
0.050881
0.086106
0.046967
0.009785
0.027397
0.005871
0.054795
0.035225
0.02544
0.037182
0.058708
0.056751
0.007828
0.011742
0.019569
0
33,951
G
T
C
G
G
T
C
A
G
C
A
G
C
A
G
C
T
G
G
T
A
A
G
C
T
T
C
C
T
G
G
A
T
A
G
A
C
A
G
T
G
G
C
A
G
G
T
C
T
T
G
G
T
G
G
A
A
G
A
G
G
T
G
G
A
G
0.005871
0.015656
0.035225
0.015656
0.035225
0.04501
0.007828
0.033268
0.027397
0.052838
0.048924
0.019569
0.021526
0.029354
0.023483
0.058708
0.078278
0.07045
0.054795
0.007828
0.005871
0.005871
0.011742
0.035225
0.027397
0.023483
0.046967
0.043053
0.039139
0.023483
0.015656
0.035225
0
33,952
G
G
T
G
A
G
G
G
G
C
C
C
G
G
C
G
C
T
G
G
C
T
C
C
T
C
T
G
C
A
C
C
T
G
C
C
G
C
C
G
C
T
G
C
A
G
C
A
G
C
T
C
C
T
T
G
T
A
C
T
C
C
C
G
C
G
0.003914
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0.023483
0.02544
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0.017613
0.02544
0.07045
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0
0.017613
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0.088063
0.064579
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0.007828
0.046967
0
0.050881
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0.019569
0.04501
0.076321
0.056751
0.007828
0.003914
0.02544
0
33,953
G
C
T
G
C
A
G
A
C
A
A
C
A
C
A
C
C
T
T
C
C
T
G
A
T
G
G
A
G
G
T
G
C
C
C
G
G
T
A
A
G
T
T
T
C
C
A
A
G
C
A
G
T
G
C
C
G
T
C
T
C
T
G
C
A
T
0.031311
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0.035225
0.04501
0.021526
0.019569
0.033268
0
33,954
T
G
G
C
T
C
C
A
G
A
A
C
G
G
G
T
G
C
C
G
A
T
G
G
C
C
A
G
G
A
T
G
C
G
C
A
G
G
G
A
C
G
G
G
C
T
G
T
A
G
C
C
G
A
G
G
G
C
G
C
T
G
G
G
C
T
0.031311
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0.011742
0.007828
0.017613
0
33,955
T
G
T
T
C
C
T
C
A
C
C
G
A
C
A
C
G
G
A
C
C
C
C
A
A
C
G
A
G
A
A
C
T
T
C
A
G
T
G
C
C
C
A
G
G
G
C
G
A
G
G
A
C
G
A
G
T
G
G
C
C
C
C
C
A
C
0.005871
0.011742
0.019569
0
0.02544
0.041096
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0.019569
0.027397
0.043053
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0.013699
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0.019569
0.021526
0.052838
0.074364
0.04501
0.021526
0
0.021526
0
33,956
G
T
G
T
G
C
C
T
C
C
C
G
C
C
G
A
G
C
G
G
A
G
A
A
T
G
G
A
T
G
A
G
C
C
T
G
T
G
C
G
G
G
C
A
G
A
G
C
A
G
G
G
T
G
A
G
T
G
C
T
G
G
G
C
A
T
0.007828
0.013699
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0.027397
0.04501
0.007828
0.011742
0.031311
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0.064579
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0.017613
0.009785
0.062622
0.017613
0.021526
0.046967
0.066536
0.046967
0.005871
0.003914
0.017613
0
33,957
C
G
G
T
G
G
C
A
G
G
C
T
C
G
G
C
C
G
C
C
G
G
T
T
T
C
G
C
C
C
T
G
T
C
C
G
C
C
T
G
C
C
C
G
C
G
G
T
C
G
G
A
A
C
G
G
C
G
T
T
C
C
C
G
G
G
0.015656
0.013699
0.023483
0.001957
0.005871
0.023483
0.019569
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0.023483
0.04501
0.064579
0
0.005871
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0.009785
0.015656
0.064579
0.046967
0.105675
0.084149
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0.080235
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0.046967
0.029354
0.023483
0.037182
0.111546
0.060665
0.003914
0
0.005871
0
33,958
C
G
A
G
G
C
C
C
A
G
G
A
G
A
G
C
G
G
C
A
G
C
C
A
G
C
G
C
G
G
C
A
C
A
G
C
C
C
G
G
G
A
G
C
T
G
C
G
G
C
C
C
A
C
G
C
C
G
G
A
G
C
C
T
A
G
0.011742
0.005871
0.017613
0.003914
0.013699
0.015656
0.029354
0.009785
0.013699
0.062622
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0.009785
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0.066536
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0.058708
0.015656
0.046967
0.021526
0.099804
0.076321
0.005871
0.001957
0.005871
0
33,959
G
C
C
C
A
G
G
A
G
A
G
C
G
G
C
A
G
C
C
A
G
C
G
C
G
G
C
A
C
A
G
C
C
C
G
G
G
A
G
C
T
G
C
G
G
C
C
C
A
C
G
C
C
G
G
A
G
C
C
T
A
C
G
G
A
A
0.011742
0.005871
0.019569
0.003914
0.013699
0.015656
0.029354
0.009785
0.013699
0.062622
0.050881
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0.009785
0.007828
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0.041096
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0.031311
0.066536
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0.058708
0.017613
0.046967
0.019569
0.097847
0.076321
0.005871
0.001957
0.005871
0
33,960
C
G
G
G
G
C
C
G
G
G
A
A
G
G
G
T
C
G
T
C
G
G
G
G
A
C
G
G
G
G
C
C
C
C
T
G
G
G
A
G
C
C
A
G
C
G
A
G
C
A
T
T
C
C
G
G
C
G
G
G
G
A
C
T
C
T
0.011742
0.007828
0.011742
0.005871
0.021526
0.02544
0.023483
0.011742
0.007828
0.064579
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0.011742
0.011742
0.017613
0.056751
0.046967
0.086106
0.097847
0.04501
0.064579
0.003914
0.054795
0.013699
0.052838
0.02544
0.09589
0.066536
0.003914
0
0.003914
0
33,961
C
C
G
C
T
T
C
G
C
C
C
T
C
G
C
C
T
G
C
C
G
C
C
G
C
T
G
G
C
A
C
C
T
G
C
C
C
C
A
C
C
G
C
C
T
T
T
C
C
G
A
C
C
T
G
G
T
G
G
C
G
C
G
G
A
C
0.003914
0.003914
0.011742
0.003914
0.009785
0.021526
0.009785
0.009785
0.005871
0.062622
0.062622
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0
0.005871
0.007828
0.013699
0.062622
0.046967
0.088063
0.09589
0.043053
0.101761
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0.062622
0.011742
0.031311
0.029354
0.127202
0.054795
0.001957
0
0.003914
0
33,962
G
C
C
A
C
C
A
G
G
T
C
G
G
A
A
A
G
G
C
G
G
T
G
G
G
G
C
A
G
G
T
G
C
C
A
G
C
G
G
C
G
G
C
A
G
G
C
G
A
G
G
G
C
G
A
A
G
C
G
G
G
A
G
C
C
G
0.003914
0.003914
0.011742
0.003914
0.009785
0.021526
0.009785
0.009785
0.005871
0.062622
0.064579
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0
0.005871
0.007828
0.013699
0.064579
0.046967
0.086106
0.093933
0.041096
0.101761
0.003914
0.062622
0.011742
0.031311
0.031311
0.129159
0.052838
0.001957
0
0.003914
0
33,963
G
G
T
C
C
C
G
G
C
C
C
T
C
G
T
C
A
C
C
T
C
T
C
T
C
G
T
G
A
C
C
C
C
G
C
C
C
C
T
C
G
T
C
C
G
C
T
T
T
C
C
C
G
C
A
G
C
C
C
C
G
C
C
C
C
T
0.011742
0.007828
0.023483
0
0.005871
0.037182
0.031311
0.005871
0.017613
0.037182
0.056751
0.001957
0.013699
0.007828
0.009785
0.02544
0.037182
0.037182
0.138943
0.082192
0.043053
0.066536
0.005871
0.052838
0.019569
0.033268
0.023483
0.091977
0.04501
0.013699
0.001957
0.013699
0
33,964
C
T
C
T
C
T
G
G
T
G
G
T
C
C
C
G
G
C
C
C
T
C
G
T
C
A
C
C
T
C
T
C
T
C
G
T
G
A
C
C
C
C
G
C
C
C
C
T
C
G
T
C
C
G
C
T
T
T
C
C
C
G
C
A
G
C
0.011742
0.007828
0.023483
0
0.005871
0.037182
0.033268
0.005871
0.017613
0.035225
0.056751
0.001957
0.013699
0.007828
0.009785
0.02544
0.033268
0.037182
0.1409
0.082192
0.04501
0.066536
0.005871
0.052838
0.019569
0.035225
0.019569
0.093933
0.04501
0.013699
0.001957
0.013699
0
33,965
C
G
T
A
C
C
C
T
C
T
C
T
G
G
T
G
G
T
C
C
C
G
G
C
C
C
T
C
G
T
C
A
C
C
T
C
T
C
T
C
G
T
G
A
C
C
C
C
G
C
C
C
C
T
C
G
T
C
C
G
C
T
T
T
C
G
0.011742
0.007828
0.023483
0
0.005871
0.037182
0.033268
0.005871
0.017613
0.039139
0.056751
0.001957
0.013699
0.007828
0.009785
0.02544
0.035225
0.037182
0.1409
0.078278
0.046967
0.062622
0.005871
0.054795
0.019569
0.035225
0.021526
0.09002
0.04501
0.013699
0.001957
0.013699
0
33,966
G
C
T
T
A
G
C
A
G
G
G
C
T
G
G
G
G
G
G
T
A
T
G
C
C
G
A
G
G
G
C
T
T
C
C
C
C
T
G
G
T
G
G
C
C
G
C
T
C
C
C
C
G
C
A
G
G
T
C
C
C
G
A
C
A
C
0.007828
0.007828
0.02544
0
0.009785
0.035225
0.037182
0.009785
0.019569
0.043053
0.056751
0.001957
0.015656
0.005871
0.009785
0.037182
0.043053
0.037182
0.1409
0.062622
0.04501
0.050881
0.005871
0.050881
0.021526
0.037182
0.033268
0.076321
0.04501
0.009785
0.001957
0.015656
0
33,967
C
A
C
C
C
G
A
C
G
G
G
C
C
T
T
C
C
C
T
C
G
A
C
G
A
G
A
G
C
G
G
C
T
C
C
A
G
C
A
G
T
G
A
G
G
C
G
G
A
G
T
T
G
G
A
G
A
C
C
C
T
C
A
A
T
C
0
0.009785
0.019569
0.001957
0.009785
0.031311
0.029354
0.015656
0.021526
0.04501
0.072407
0
0.011742
0.005871
0.013699
0.035225
0.052838
0.037182
0.107632
0.056751
0.039139
0.043053
0.005871
0.076321
0.017613
0.039139
0.043053
0.072407
0.066536
0.001957
0
0.017613
0
33,968
G
A
C
C
C
T
C
G
T
G
G
G
G
G
C
C
T
G
A
G
C
C
C
T
G
C
G
C
C
C
A
G
C
G
C
A
C
C
G
G
G
G
G
C
T
C
G
T
C
A
T
T
G
A
G
G
G
T
C
T
C
C
A
A
C
T
0
0.005871
0.023483
0.001957
0.007828
0.033268
0.027397
0.011742
0.021526
0.046967
0.078278
0
0.003914
0.005871
0.013699
0.037182
0.052838
0.035225
0.109589
0.062622
0.035225
0.039139
0.005871
0.076321
0.017613
0.037182
0.046967
0.082192
0.060665
0.001957
0
0.017613
0
33,969
C
G
G
T
G
C
T
G
G
A
G
A
G
G
G
A
C
C
T
G
G
A
G
C
T
G
A
G
C
C
T
C
C
G
G
C
C
G
G
G
C
C
T
G
G
A
G
G
C
G
C
C
A
C
C
C
T
T
C
C
C
C
G
G
T
G
0.003914
0.011742
0.02544
0.009785
0.009785
0.041096
0.019569
0.005871
0.021526
0.048924
0.084149
0.007828
0.011742
0.017613
0.021526
0.027397
0.048924
0.041096
0.078278
0.052838
0.017613
0.043053
0.013699
0.072407
0.017613
0.027397
0.039139
0.072407
0.064579
0.007828
0.009785
0.02544
0
33,970
A
A
A
G
C
T
G
C
T
G
A
G
T
A
T
A
G
G
C
A
G
C
A
T
A
T
C
C
T
C
C
A
C
C
T
G
T
A
C
A
G
G
G
A
G
G
G
G
T
G
T
T
C
A
A
G
C
A
T
C
C
C
T
G
G
A
0.007828
0.007828
0.033268
0.005871
0.021526
0.04501
0.007828
0.017613
0.037182
0.046967
0.078278
0.009785
0.017613
0.029354
0.019569
0.029354
0.093933
0.066536
0.082192
0.007828
0.001957
0.005871
0.017613
0.035225
0.02544
0.033268
0.056751
0.062622
0.046967
0.021526
0.001957
0.02544
0
33,971
G
G
C
A
T
G
G
C
C
A
A
A
G
C
T
G
C
T
G
A
G
T
A
T
A
G
G
C
A
G
C
A
T
A
T
C
C
T
C
C
A
C
C
T
G
T
A
C
A
G
G
G
A
G
G
G
G
T
G
T
T
C
A
A
G
C
0.007828
0.007828
0.033268
0.005871
0.023483
0.04501
0.007828
0.017613
0.039139
0.04501
0.076321
0.009785
0.017613
0.029354
0.019569
0.031311
0.091977
0.066536
0.086106
0.007828
0.001957
0.005871
0.017613
0.035225
0.02544
0.033268
0.056751
0.060665
0.04501
0.021526
0.001957
0.02544
0
33,972
C
C
G
C
T
C
T
A
T
G
G
A
G
T
C
C
A
G
C
C
C
T
G
C
C
A
G
C
A
G
C
T
T
G
T
A
A
A
A
A
A
C
A
T
G
G
A
A
G
C
T
C
C
G
C
T
C
A
G
C
C
T
G
G
G
C
0.011742
0.007828
0.027397
0.001957
0.027397
0.033268
0.001957
0.02544
0.037182
0.04501
0.082192
0.007828
0.013699
0.015656
0.013699
0.039139
0.072407
0.046967
0.09002
0.029354
0.007828
0.011742
0.02544
0.068493
0.011742
0.023483
0.04501
0.074364
0.050881
0.017613
0.011742
0.021526
0
33,973
A
G
C
T
G
G
G
G
T
G
G
T
C
A
C
C
A
T
G
G
T
G
A
T
A
G
T
G
G
C
T
C
T
T
C
T
G
G
A
G
G
A
A
G
G
T
G
T
G
G
T
C
C
G
T
G
G
C
C
T
A
G
G
A
G
C
0.02544
0.015656
0.02544
0.007828
0.031311
0.04501
0.011742
0.023483
0.02544
0.039139
0.072407
0.011742
0.021526
0.021526
0.02544
0.048924
0.054795
0.054795
0.064579
0.021526
0.017613
0.015656
0.02544
0.054795
0.017613
0.029354
0.029354
0.056751
0.046967
0.017613
0.007828
0.033268
0
33,974
C
A
G
C
C
A
A
C
A
G
C
T
G
T
T
G
G
A
G
G
A
A
T
G
T
G
T
G
A
A
G
A
C
A
G
G
C
T
G
T
G
A
G
G
G
C
G
A
A
A
A
A
G
A
G
A
T
G
A
T
T
A
G
G
T
T
0.033268
0.021526
0.029354
0.019569
0.031311
0.031311
0.009785
0.029354
0.052838
0.039139
0.04501
0.007828
0.035225
0.031311
0.019569
0.037182
0.068493
0.050881
0.050881
0.015656
0.013699
0.007828
0.019569
0.048924
0.035225
0.029354
0.02544
0.04501
0.035225
0.013699
0.017613
0.048924
0
33,975
A
C
A
G
C
T
G
T
T
G
G
C
T
G
A
C
C
G
T
C
T
G
C
C
T
C
A
T
C
T
A
C
C
C
T
T
G
G
G
C
C
A
G
A
T
G
C
T
G
G
T
G
A
C
A
G
A
G
C
T
G
G
G
G
A
A
0.035225
0.02544
0.033268
0.023483
0.033268
0.029354
0.009785
0.033268
0.056751
0.039139
0.035225
0.009785
0.031311
0.033268
0.023483
0.035225
0.068493
0.056751
0.058708
0.009785
0.007828
0.003914
0.021526
0.041096
0.035225
0.029354
0.029354
0.039139
0.031311
0.015656
0.023483
0.041096
0