row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
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string
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string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_32_ref_0
string
f_33_ref__1
string
f_34_ref__2
string
f_35_ref__3
string
f_36_ref__4
string
f_37_ref__5
string
f_38_ref__6
string
f_39_ref__7
string
f_40_ref__8
string
f_41_ref__9
string
f_42_ref__10
string
f_43_ref__11
string
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string
f_45_ref__13
string
f_46_ref__14
string
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string
f_48_ref__16
string
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string
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string
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string
f_52_ref__20
string
f_53_ref__21
string
f_54_ref__22
string
f_55_ref__23
string
f_56_ref__24
string
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string
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string
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string
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string
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string
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string
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string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
7,591
C
A
G
C
T
A
C
A
A
G
T
G
G
G
A
C
T
T
T
G
G
T
G
G
C
T
C
G
T
G
C
A
T
G
A
C
A
G
G
A
G
A
G
G
T
C
A
T
A
A
C
A
G
G
A
A
C
G
A
T
C
A
G
C
A
C
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0
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1
7,592
T
T
C
A
A
A
T
A
C
C
G
T
A
T
A
C
A
T
G
A
T
C
C
T
A
C
C
C
A
G
G
C
C
G
A
A
G
G
A
A
G
G
T
T
C
A
A
T
T
A
C
A
T
T
C
G
G
A
A
C
A
A
C
T
T
G
0.054795
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1
7,593
A
T
C
A
G
T
C
C
T
G
G
C
A
T
A
G
C
G
C
C
T
T
C
C
G
A
T
T
G
A
C
C
C
A
G
A
G
G
A
A
T
C
G
T
C
T
A
C
T
T
T
G
T
G
A
G
A
T
A
C
T
C
C
A
T
G
0.086106
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1
7,594
C
A
G
C
A
T
C
G
G
T
T
C
T
G
C
C
C
T
G
G
G
C
T
T
C
A
A
A
T
A
C
C
C
G
G
T
G
G
G
G
A
A
C
A
A
C
C
A
G
A
C
G
G
C
G
G
T
C
C
A
G
G
A
C
A
T
0.007828
0.015656
0.027397
0.007828
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0.015656
0.015656
0.033268
0.054795
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0.033268
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0.033268
0.09002
0.029354
0.005871
0.001957
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1
7,595
C
A
C
C
G
T
G
G
G
C
C
A
T
A
G
C
A
T
C
T
C
T
A
T
T
G
T
A
G
C
C
C
T
C
T
T
C
G
T
G
G
C
C
A
T
C
A
C
C
A
T
C
C
T
G
G
T
T
G
C
T
C
T
C
A
A
0.029354
0.017613
0.058708
0.017613
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0.007828
0.021526
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0.013699
0.02544
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0.037182
0.041096
0.060665
0.04501
0.003914
0.003914
0.007828
0.02544
0.048924
0.050881
0.017613
0.027397
0.039139
0.046967
0.019569
0.011742
0.033268
1
7,596
C
G
C
C
A
C
C
A
T
G
A
C
C
A
A
C
T
T
C
A
G
C
T
G
G
C
T
G
T
T
G
G
C
A
G
A
A
G
C
C
G
T
C
T
A
C
C
T
G
A
A
C
T
G
C
C
T
C
C
T
G
G
C
C
T
A
0.011742
0.021526
0.027397
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0.023483
0.050881
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0.021526
0.043053
0.043053
0.072407
0.013699
0.011742
0.021526
0.019569
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0.076321
0.086106
0.082192
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0.007828
0.009785
0.064579
0.021526
0.019569
0.023483
0.07045
0.046967
0.015656
0.011742
0.023483
1
7,597
G
G
C
C
T
C
C
A
C
C
T
C
C
C
C
C
A
G
C
T
C
A
A
G
G
A
G
A
G
C
C
T
T
C
T
G
G
T
G
G
C
T
G
G
T
T
C
T
C
G
C
T
G
G
C
T
G
G
G
G
T
G
A
G
C
G
0.011742
0.019569
0.02544
0.001957
0.017613
0.050881
0.005871
0.021526
0.035225
0.043053
0.080235
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0.005871
0.021526
0.017613
0.041096
0.082192
0.091977
0.078278
0.009785
0.003914
0.009785
0.011742
0.060665
0.021526
0.021526
0.031311
0.080235
0.048924
0.013699
0.007828
0.021526
1
7,598
T
C
C
A
A
A
G
A
G
T
G
G
G
A
T
C
A
G
G
A
A
A
A
G
T
G
T
C
G
A
C
T
T
G
G
A
G
A
G
A
C
G
C
C
T
G
C
A
G
G
A
A
A
G
A
C
A
A
A
T
C
C
T
A
G
C
0.043053
0.021526
0.035225
0.023483
0.033268
0.019569
0.007828
0.035225
0.041096
0.023483
0.052838
0.021526
0.039139
0.02544
0.031311
0.04501
0.058708
0.062622
0.058708
0.003914
0.005871
0.009785
0.019569
0.039139
0.041096
0.023483
0.029354
0.039139
0.060665
0.005871
0.007828
0.035225
1
7,599
A
C
T
T
C
C
T
G
C
C
A
G
A
C
A
A
T
G
C
T
G
G
C
C
T
G
G
G
C
A
T
C
C
G
C
C
T
C
C
C
C
C
T
G
G
A
G
C
T
G
G
G
A
C
T
G
G
G
T
T
C
C
T
T
C
T
0.035225
0.017613
0.033268
0.023483
0.031311
0.021526
0.011742
0.029354
0.043053
0.021526
0.048924
0.017613
0.043053
0.050881
0.02544
0.043053
0.050881
0.076321
0.050881
0.003914
0.005871
0.005871
0.019569
0.039139
0.04501
0.023483
0.029354
0.037182
0.07045
0.009785
0.003914
0.031311
1
7,600
A
T
T
G
G
C
C
A
C
T
C
C
A
T
C
T
G
C
C
A
T
T
C
T
T
A
A
G
T
C
T
C
C
T
T
G
G
G
A
G
T
C
T
C
C
C
A
G
A
A
G
A
A
T
T
A
T
G
T
T
A
C
T
A
T
G
0.097847
0.023483
0.037182
0.076321
0.039139
0.009785
0
0.035225
0.050881
0.015656
0.027397
0.056751
0.037182
0.041096
0.048924
0.019569
0.019569
0.021526
0.011742
0.005871
0.009785
0
0.035225
0.039139
0.041096
0.015656
0.019569
0.019569
0.023483
0.02544
0.046967
0.048924
1
7,601
A
T
A
T
T
C
T
T
A
C
A
G
T
T
T
C
A
T
C
A
A
A
A
T
C
C
A
T
A
A
A
A
T
T
G
G
A
C
A
C
A
A
C
T
T
T
G
A
C
A
T
T
G
G
G
A
T
G
A
T
A
A
A
C
A
C
0.088063
0.033268
0.046967
0.072407
0.033268
0.003914
0.005871
0.037182
0.037182
0.02544
0.017613
0.09002
0.041096
0.039139
0.031311
0.017613
0.017613
0.031311
0.015656
0.007828
0.011742
0.001957
0.031311
0.021526
0.046967
0.009785
0.005871
0.017613
0.035225
0.019569
0.07045
0.035225
1
7,602
A
A
G
G
G
T
A
C
T
T
C
T
C
T
T
C
T
A
C
A
G
T
A
A
G
A
A
C
A
G
G
A
T
C
A
A
C
T
T
C
A
A
T
A
G
C
G
T
A
A
T
A
T
T
T
T
T
C
C
T
T
T
A
G
T
A
0.113503
0.048924
0.052838
0.072407
0.041096
0.015656
0.001957
0.041096
0.035225
0.023483
0.02544
0.060665
0.033268
0.029354
0.058708
0.007828
0.02544
0.011742
0.001957
0
0
0.001957
0.031311
0.015656
0.035225
0.003914
0.033268
0.003914
0.017613
0.039139
0.080235
0.037182
1
7,603
A
A
G
C
A
A
A
T
T
A
C
C
T
T
T
T
A
C
A
C
C
A
C
C
A
A
A
T
G
A
T
C
C
A
T
A
G
G
T
C
A
T
A
T
T
G
C
A
G
G
C
T
G
T
T
C
T
C
T
G
A
A
G
A
T
T
0.093933
0.023483
0.037182
0.072407
0.04501
0.027397
0.001957
0.029354
0.031311
0.015656
0.031311
0.054795
0.037182
0.050881
0.043053
0.027397
0.027397
0.037182
0.011742
0.001957
0.003914
0
0.029354
0.015656
0.035225
0.019569
0.019569
0.015656
0.02544
0.033268
0.054795
0.046967
1
7,604
T
T
T
T
G
G
A
A
G
A
T
T
T
C
T
C
C
C
T
G
G
C
T
T
T
C
T
T
C
T
G
C
C
T
G
G
T
C
C
T
C
T
T
G
C
C
T
A
C
A
G
T
T
C
C
C
G
T
A
C
A
G
A
T
T
G
0.09589
0.017613
0.048924
0.076321
0.035225
0.015656
0.003914
0.029354
0.052838
0.023483
0.021526
0.062622
0.039139
0.037182
0.041096
0.023483
0.02544
0.027397
0.005871
0.005871
0.007828
0.001957
0.033268
0.019569
0.04501
0.019569
0.029354
0.011742
0.027397
0.023483
0.056751
0.035225
1
7,605
G
A
A
A
G
A
G
A
C
A
A
T
A
C
A
T
A
T
G
T
C
A
A
G
G
G
C
T
T
G
C
T
C
T
C
C
A
A
T
A
T
T
T
A
G
A
G
T
C
C
A
A
T
C
C
A
C
C
T
A
C
A
A
A
G
T
0.109589
0.027397
0.052838
0.066536
0.04501
0.015656
0
0.023483
0.056751
0.02544
0.015656
0.078278
0.031311
0.041096
0.058708
0.019569
0.019569
0.031311
0.005871
0.001957
0.005871
0
0.019569
0.029354
0.04501
0.017613
0.017613
0.015656
0.017613
0.019569
0.043053
0.043053
1
7,606
A
G
A
G
C
C
C
G
G
C
G
T
T
T
G
C
A
C
G
G
T
G
T
T
T
G
G
A
G
A
T
C
C
C
C
A
C
T
A
C
A
A
C
A
C
T
T
T
T
G
A
C
G
G
T
C
G
G
A
C
A
T
T
T
A
T
0.07045
0.027397
0.043053
0.019569
0.02544
0.037182
0.029354
0.029354
0.031311
0.037182
0.041096
0.007828
0.011742
0.007828
0.027397
0.048924
0.048924
0.033268
0.039139
0.029354
0.019569
0.039139
0.005871
0.041096
0.037182
0.033268
0.039139
0.029354
0.037182
0.013699
0.023483
0.035225
1
7,607
G
A
C
A
A
A
T
T
C
C
A
T
G
A
G
C
T
G
G
G
C
A
C
C
G
A
G
A
T
G
A
T
C
A
T
C
A
C
C
A
A
G
T
C
G
G
G
C
A
G
G
T
A
G
T
T
G
G
G
A
C
T
T
G
G
G
0.023483
0.015656
0.02544
0.023483
0.021526
0.037182
0.005871
0.027397
0.031311
0.060665
0.046967
0
0.023483
0.035225
0.041096
0.039139
0.064579
0.080235
0.07045
0.007828
0.005871
0.003914
0.015656
0.060665
0.019569
0.029354
0.039139
0.037182
0.058708
0.007828
0.003914
0.037182
1
7,608
G
T
G
T
A
A
A
A
T
A
C
A
G
C
T
T
T
T
G
A
T
G
G
G
T
T
T
A
G
G
A
A
C
G
T
C
A
A
A
A
A
G
A
A
C
T
A
G
C
A
T
G
T
C
T
T
C
G
T
G
G
C
C
G
A
T
0.127202
0.054795
0.035225
0.058708
0.058708
0.017613
0.011742
0.039139
0.035225
0.011742
0.015656
0.039139
0.021526
0.033268
0.050881
0.02544
0.027397
0.029354
0.015656
0.009785
0.007828
0.001957
0.027397
0.011742
0.043053
0.015656
0.021526
0.017613
0.021526
0.031311
0.054795
0.027397
1
7,609
T
T
A
G
C
C
T
T
T
T
C
T
T
A
C
C
T
C
T
G
G
A
C
T
T
A
C
C
A
C
A
C
C
A
A
C
T
G
T
T
T
G
T
G
C
C
A
A
T
G
G
T
G
C
A
A
G
T
A
A
A
G
A
C
A
A
0.066536
0.029354
0.058708
0.037182
0.035225
0.021526
0.005871
0.043053
0.054795
0.023483
0.039139
0.027397
0.035225
0.037182
0.041096
0.029354
0.037182
0.037182
0.009785
0
0.007828
0.001957
0.02544
0.037182
0.04501
0.02544
0.021526
0.023483
0.031311
0.021526
0.039139
0.050881
1
7,610
C
T
G
A
T
G
G
A
A
G
A
A
T
A
G
G
G
G
A
A
A
G
G
C
A
C
G
A
C
T
C
A
C
A
G
A
T
G
T
T
C
T
C
C
T
C
T
G
T
A
A
G
A
A
A
A
C
A
C
A
C
A
T
A
C
A
0.076321
0.031311
0.050881
0.046967
0.029354
0.027397
0.013699
0.027397
0.04501
0.033268
0.031311
0.033268
0.02544
0.043053
0.031311
0.035225
0.039139
0.043053
0.019569
0.003914
0.009785
0
0.019569
0.029354
0.058708
0.009785
0.035225
0.021526
0.027397
0.021526
0.039139
0.041096
1
7,611
T
T
A
C
C
T
T
T
T
C
A
A
G
T
G
G
G
C
A
A
T
G
G
G
T
A
C
T
G
T
C
T
C
G
G
A
G
A
A
A
G
G
G
A
A
G
T
A
A
G
T
T
T
G
G
T
C
G
A
T
C
A
T
A
T
G
0.076321
0.029354
0.066536
0.027397
0.037182
0.033268
0.003914
0.029354
0.066536
0.031311
0.033268
0.019569
0.02544
0.039139
0.041096
0.017613
0.037182
0.037182
0.035225
0.005871
0.007828
0.001957
0.019569
0.037182
0.048924
0.033268
0.021526
0.011742
0.031311
0.021526
0.033268
0.039139
1
7,612
T
T
G
C
A
C
C
T
C
T
C
T
G
T
G
A
T
C
A
G
C
T
T
G
T
T
G
T
A
C
T
T
T
C
G
T
A
T
G
T
A
A
A
G
G
A
G
A
T
T
T
C
A
G
A
A
A
A
A
A
C
G
G
T
A
C
0.082192
0.041096
0.039139
0.033268
0.046967
0.021526
0.015656
0.039139
0.037182
0.029354
0.035225
0.029354
0.033268
0.031311
0.039139
0.031311
0.052838
0.017613
0.027397
0.007828
0.005871
0.001957
0.021526
0.027397
0.041096
0.019569
0.039139
0.011742
0.027397
0.031311
0.031311
0.050881
1
7,613
T
T
G
G
T
T
G
A
C
G
G
G
G
G
A
G
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
G
A
G
C
T
G
G
A
G
C
T
G
G
A
G
C
T
G
A
0.023483
0.031311
0.031311
0.007828
0.027397
0.039139
0.001957
0.023483
0.039139
0.093933
0.035225
0.003914
0.007828
0.011742
0.033268
0.035225
0.09589
0.066536
0.068493
0.011742
0.003914
0.021526
0.011742
0.052838
0.029354
0.017613
0.058708
0.033268
0.041096
0.007828
0.009785
0.023483
1
7,614
C
A
T
G
A
A
C
T
G
T
A
G
A
G
T
C
A
G
A
G
C
T
G
A
C
T
T
G
C
C
C
A
C
G
C
C
A
C
C
A
C
T
G
C
C
C
A
C
C
A
T
G
A
T
G
A
C
T
T
T
G
T
G
T
A
A
0.101761
0.02544
0.058708
0.060665
0.037182
0.015656
0.003914
0.043053
0.046967
0.031311
0.021526
0.031311
0.029354
0.039139
0.039139
0.02544
0.029354
0.031311
0.009785
0
0.001957
0.001957
0.033268
0.023483
0.046967
0.013699
0.017613
0.019569
0.017613
0.035225
0.060665
0.046967
1
7,615
C
T
T
C
T
A
C
A
G
A
A
A
C
C
T
G
T
C
T
T
T
T
A
T
C
T
T
C
T
A
A
A
T
C
T
G
A
T
T
T
G
T
T
A
C
C
A
A
C
C
A
G
T
A
G
A
A
A
T
G
G
A
A
C
A
C
0.09589
0.050881
0.041096
0.052838
0.050881
0.021526
0.009785
0.033268
0.052838
0.02544
0.023483
0.041096
0.035225
0.037182
0.043053
0.019569
0.033268
0.027397
0.009785
0
0.005871
0
0.033268
0.027397
0.039139
0.011742
0.023483
0.005871
0.023483
0.033268
0.060665
0.031311
1
7,616
C
T
G
A
G
C
A
G
T
G
G
A
A
T
G
T
T
A
A
C
T
A
C
G
T
G
G
A
A
A
C
A
T
C
T
G
C
T
A
A
A
A
C
A
C
G
A
G
C
T
A
A
T
G
T
T
G
A
C
A
A
G
G
T
A
G
0.097847
0.050881
0.043053
0.04501
0.054795
0.019569
0.009785
0.033268
0.058708
0.027397
0.027397
0.031311
0.029354
0.043053
0.033268
0.017613
0.033268
0.02544
0.011742
0
0.001957
0
0.039139
0.031311
0.041096
0.015656
0.017613
0.005871
0.027397
0.035225
0.062622
0.029354
1
7,617
T
G
A
G
C
A
G
T
G
G
A
A
T
G
T
T
A
A
C
T
A
C
G
T
G
G
A
A
A
C
A
T
C
T
G
C
T
A
A
A
A
C
A
C
G
A
G
C
T
A
A
T
G
T
T
G
A
C
A
A
G
G
T
A
A
T
0.099804
0.050881
0.043053
0.04501
0.054795
0.019569
0.009785
0.033268
0.058708
0.027397
0.027397
0.031311
0.029354
0.043053
0.033268
0.017613
0.033268
0.02544
0.011742
0
0.001957
0
0.039139
0.031311
0.041096
0.015656
0.017613
0.005871
0.027397
0.033268
0.062622
0.029354
1
7,618
A
T
C
C
C
T
G
G
C
T
T
T
G
T
A
A
A
C
T
T
G
T
C
C
G
T
A
A
G
T
A
C
C
T
T
C
T
C
C
A
A
T
A
A
T
T
C
C
G
A
T
G
A
T
A
T
C
A
A
A
T
T
T
A
T
G
0.107632
0.031311
0.04501
0.066536
0.04501
0.013699
0.007828
0.035225
0.041096
0.011742
0.011742
0.086106
0.037182
0.029354
0.054795
0.021526
0.021526
0.033268
0.023483
0.005871
0.005871
0.007828
0.021526
0.011742
0.043053
0.009785
0.015656
0.015656
0.023483
0.039139
0.04501
0.031311
1
7,619
T
A
T
C
C
C
T
G
G
C
T
T
T
G
T
A
A
A
C
T
T
G
T
C
C
G
T
A
A
G
T
A
C
C
T
T
C
T
C
C
A
A
T
A
A
T
T
C
C
G
A
T
G
A
T
A
T
C
A
A
A
T
T
T
A
T
0.107632
0.031311
0.04501
0.066536
0.04501
0.013699
0.007828
0.035225
0.041096
0.011742
0.013699
0.086106
0.037182
0.029354
0.052838
0.021526
0.021526
0.033268
0.023483
0.005871
0.005871
0.007828
0.021526
0.011742
0.043053
0.009785
0.015656
0.015656
0.023483
0.039139
0.04501
0.031311
1
7,620
T
A
T
C
C
C
T
G
G
C
T
T
T
G
T
A
A
A
C
T
T
G
T
C
C
G
T
A
A
G
T
A
C
C
T
T
C
T
C
C
A
A
T
A
A
T
T
C
C
G
A
T
G
A
T
A
T
C
A
A
A
T
T
T
A
A
0.107632
0.031311
0.04501
0.066536
0.04501
0.013699
0.007828
0.035225
0.041096
0.011742
0.013699
0.086106
0.037182
0.029354
0.052838
0.021526
0.021526
0.033268
0.023483
0.005871
0.005871
0.007828
0.021526
0.011742
0.043053
0.009785
0.015656
0.015656
0.023483
0.039139
0.04501
0.031311
1
7,621
A
G
T
G
T
C
T
T
T
A
T
C
C
C
T
G
G
C
T
T
T
G
T
A
A
A
C
T
T
G
T
C
C
G
T
A
A
G
T
A
C
C
T
T
C
T
C
C
A
A
T
A
A
T
T
C
C
G
A
T
G
A
T
A
T
T
0.107632
0.031311
0.046967
0.066536
0.043053
0.013699
0.007828
0.035225
0.041096
0.011742
0.013699
0.088063
0.035225
0.029354
0.052838
0.019569
0.019569
0.033268
0.023483
0.005871
0.005871
0.007828
0.023483
0.011742
0.043053
0.009785
0.015656
0.015656
0.023483
0.041096
0.046967
0.029354
1
7,622
A
G
C
C
T
T
C
C
T
T
T
T
C
A
T
T
A
T
C
C
A
G
A
C
G
T
A
C
T
T
T
T
T
T
T
A
A
G
G
C
T
A
C
C
A
T
T
T
C
T
C
C
T
A
T
T
A
A
G
G
A
A
T
T
T
G
0.121331
0.031311
0.043053
0.101761
0.035225
0.017613
0.005871
0.029354
0.035225
0.015656
0.019569
0.072407
0.021526
0.037182
0.041096
0.009785
0.023483
0.02544
0.003914
0.003914
0.005871
0
0.021526
0.011742
0.056751
0.013699
0.013699
0.005871
0.02544
0.033268
0.080235
0.037182
1
7,623
T
A
A
T
A
G
G
A
G
A
A
A
T
G
G
T
A
G
C
C
T
T
A
A
A
A
A
A
A
G
T
A
C
G
T
C
T
G
G
A
T
A
A
T
G
A
A
A
A
G
G
A
A
G
G
C
T
T
T
C
C
A
A
T
T
T
0.119374
0.031311
0.041096
0.103718
0.035225
0.017613
0.005871
0.029354
0.033268
0.017613
0.019569
0.072407
0.021526
0.037182
0.043053
0.009785
0.023483
0.02544
0.003914
0.003914
0.005871
0
0.021526
0.013699
0.052838
0.013699
0.015656
0.005871
0.02544
0.033268
0.080235
0.037182
1
7,624
G
A
T
G
G
G
T
A
A
G
C
T
G
C
C
G
G
A
G
A
A
T
T
T
T
A
A
T
T
T
C
T
C
G
A
A
T
T
G
C
T
G
T
A
A
T
T
G
G
A
A
A
G
C
C
T
T
C
C
T
T
T
T
C
A
T
0.125245
0.033268
0.043053
0.099804
0.031311
0.015656
0.007828
0.033268
0.035225
0.017613
0.017613
0.066536
0.023483
0.033268
0.04501
0.011742
0.021526
0.021526
0.001957
0.003914
0.007828
0
0.023483
0.015656
0.054795
0.013699
0.015656
0.005871
0.021526
0.029354
0.080235
0.043053
1
7,625
G
G
T
A
T
G
C
T
T
A
C
C
T
T
T
C
T
T
C
T
G
A
G
C
T
A
T
A
C
A
A
T
C
G
A
G
C
A
A
G
T
C
C
A
A
A
G
T
C
T
G
C
A
A
G
T
T
T
T
A
T
C
T
G
C
T
0.125245
0.029354
0.048924
0.086106
0.035225
0.021526
0
0.041096
0.039139
0.013699
0.023483
0.078278
0.029354
0.029354
0.048924
0.011742
0.017613
0.015656
0.005871
0
0.003914
0
0.033268
0.017613
0.033268
0.009785
0.019569
0.005871
0.011742
0.046967
0.080235
0.037182
1
7,626
C
A
G
T
T
C
A
G
G
T
G
G
A
C
G
G
T
A
C
C
A
T
A
A
A
G
T
A
A
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T
A
C
C
T
T
G
T
T
A
G
T
A
T
A
C
G
G
C
C
G
A
C
T
A
A
A
A
A
A
C
A
C
A
G
A
0.105675
0.037182
0.041096
0.058708
0.037182
0.02544
0.007828
0.046967
0.035225
0.017613
0.029354
0.064579
0.031311
0.02544
0.031311
0.019569
0.029354
0.027397
0.011742
0.007828
0.005871
0.001957
0.043053
0.015656
0.033268
0.011742
0.013699
0.013699
0.023483
0.046967
0.072407
0.027397
1
7,627
T
G
G
T
T
C
T
A
G
G
C
C
A
G
C
C
C
A
A
G
G
A
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C
T
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C
A
A
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C
A
T
T
G
A
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C
T
T
G
A
A
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A
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T
T
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C
C
A
A
C
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C
A
T
T
A
G
C
0.099804
0.041096
0.066536
0.058708
0.046967
0.017613
0.003914
0.035225
0.033268
0.02544
0.031311
0.033268
0.039139
0.033268
0.056751
0.019569
0.023483
0.029354
0.009785
0.001957
0.001957
0.003914
0.027397
0.007828
0.048924
0.015656
0.011742
0.013699
0.031311
0.027397
0.058708
0.04501
1
7,628
G
G
G
C
G
T
C
G
G
C
G
G
C
G
G
C
C
C
T
C
C
T
G
T
G
G
C
A
G
C
C
G
C
G
T
A
C
T
T
G
G
C
C
T
T
G
A
G
G
C
G
G
T
A
C
T
G
C
T
G
G
G
C
G
G
G
0
0.005871
0.009785
0
0.007828
0.017613
0.035225
0.007828
0.013699
0.064579
0.066536
0
0.013699
0.017613
0.005871
0.029354
0.072407
0.048924
0.054795
0.064579
0.037182
0.082192
0.005871
0.064579
0.009785
0.019569
0.043053
0.131115
0.033268
0.013699
0
0.023483
1
7,629
C
C
T
C
T
G
G
G
C
C
A
T
G
C
A
C
T
G
T
C
T
T
C
A
C
A
T
G
T
T
T
C
C
G
G
A
G
G
G
A
G
C
T
T
G
G
G
T
C
T
G
T
G
T
A
A
C
G
C
T
T
A
G
T
G
T
0.041096
0.027397
0.043053
0.031311
0.041096
0.031311
0.007828
0.02544
0.041096
0.033268
0.046967
0.019569
0.015656
0.043053
0.031311
0.037182
0.041096
0.043053
0.031311
0.023483
0.013699
0.009785
0.017613
0.04501
0.041096
0.029354
0.031311
0.043053
0.039139
0.011742
0.02544
0.037182
1
7,630
A
A
T
C
C
C
A
G
G
C
T
G
C
A
C
T
A
A
G
C
G
T
T
A
C
A
C
A
G
A
C
C
C
A
A
G
C
T
C
C
C
T
C
C
G
G
A
A
A
C
A
T
G
T
G
A
A
G
A
C
A
G
T
G
C
T
0.04501
0.027397
0.041096
0.033268
0.041096
0.031311
0.007828
0.023483
0.037182
0.037182
0.04501
0.021526
0.015656
0.043053
0.031311
0.037182
0.039139
0.043053
0.031311
0.023483
0.013699
0.009785
0.021526
0.043053
0.039139
0.027397
0.031311
0.043053
0.037182
0.011742
0.031311
0.035225
1
7,631
C
C
G
A
G
A
G
C
T
G
T
T
G
C
T
G
C
T
G
C
T
C
A
T
G
C
A
G
T
A
C
C
T
G
T
G
C
C
G
A
G
A
G
T
A
C
C
G
C
G
A
T
G
G
G
A
A
C
C
C
A
C
G
T
G
C
0.003914
0.019569
0.011742
0.001957
0.027397
0.043053
0.009785
0.02544
0.021526
0.058708
0.062622
0.001957
0.015656
0.019569
0.015656
0.046967
0.086106
0.062622
0.09002
0.023483
0.017613
0.023483
0.011742
0.058708
0.015656
0.019569
0.048924
0.060665
0.04501
0.019569
0.001957
0.029354
1
7,632
T
G
G
C
C
G
G
G
G
C
G
C
G
G
C
C
C
T
G
G
T
C
T
C
G
G
C
G
G
T
G
G
C
C
T
G
T
A
A
G
A
A
G
G
C
C
T
G
T
A
T
G
C
T
G
G
G
C
C
A
G
T
G
A
G
T
0.009785
0.009785
0.031311
0.007828
0.019569
0.023483
0.017613
0.015656
0.02544
0.046967
0.07045
0.003914
0.013699
0.021526
0.013699
0.035225
0.07045
0.054795
0.082192
0.035225
0.021526
0.043053
0.007828
0.048924
0.029354
0.021526
0.048924
0.088063
0.048924
0.009785
0.005871
0.017613
1
7,633
C
T
G
G
C
C
C
A
G
C
A
T
A
C
A
G
G
C
C
T
T
C
T
T
A
C
A
G
G
C
C
A
C
C
G
C
C
G
A
G
A
C
C
A
G
G
G
C
C
G
C
G
C
C
C
C
G
G
C
C
A
C
T
G
C
T
0.009785
0.007828
0.031311
0.007828
0.017613
0.023483
0.017613
0.015656
0.02544
0.046967
0.07045
0.003914
0.013699
0.021526
0.013699
0.035225
0.07045
0.056751
0.084149
0.035225
0.021526
0.043053
0.007828
0.048924
0.029354
0.021526
0.048924
0.088063
0.048924
0.009785
0.005871
0.017613
1
7,634
G
A
C
G
C
C
C
A
G
C
T
G
C
G
A
G
A
T
C
A
C
C
T
T
C
A
T
C
G
A
G
T
C
G
G
A
G
G
A
G
G
G
C
A
G
T
G
G
C
C
G
G
G
G
C
G
C
G
G
C
C
C
T
G
G
G
0.015656
0.009785
0.039139
0.007828
0.015656
0.02544
0.015656
0.017613
0.02544
0.046967
0.066536
0.003914
0.013699
0.021526
0.019569
0.035225
0.062622
0.058708
0.074364
0.033268
0.021526
0.054795
0.005871
0.048924
0.031311
0.019569
0.04501
0.084149
0.048924
0.009785
0.003914
0.017613
1
7,635
C
C
A
G
G
G
A
G
A
G
A
G
C
G
G
G
G
C
G
G
G
C
T
C
A
C
C
T
G
G
G
G
T
G
C
A
G
C
T
T
G
T
A
C
A
C
G
G
A
G
C
C
A
T
C
C
A
C
G
C
C
C
A
C
A
C
0.011742
0.009785
0.029354
0.009785
0.021526
0.031311
0.029354
0.009785
0.027397
0.050881
0.04501
0
0.019569
0.029354
0.023483
0.035225
0.043053
0.039139
0.068493
0.039139
0.033268
0.099804
0.011742
0.048924
0.019569
0.029354
0.054795
0.048924
0.041096
0.017613
0.005871
0.015656
1
7,636
G
A
G
A
G
C
G
G
G
G
C
G
G
G
C
T
C
A
C
C
T
G
G
G
G
T
G
C
A
G
C
T
T
G
T
A
C
A
C
G
G
A
G
C
C
A
T
C
C
A
C
G
C
C
C
A
C
A
G
T
G
A
T
G
C
C
0.011742
0.009785
0.029354
0.009785
0.021526
0.031311
0.029354
0.011742
0.027397
0.052838
0.043053
0
0.019569
0.029354
0.023483
0.035225
0.043053
0.039139
0.068493
0.039139
0.033268
0.097847
0.011742
0.050881
0.019569
0.029354
0.050881
0.048924
0.041096
0.017613
0.005871
0.017613
1
7,637
C
T
C
G
C
T
G
C
G
G
C
T
C
T
C
G
C
G
C
A
T
G
C
G
G
T
T
G
A
T
G
A
C
G
C
C
C
G
C
C
A
G
C
C
C
C
G
C
C
G
A
G
C
A
C
A
T
G
T
G
C
G
C
A
G
G
0.011742
0.009785
0.021526
0.009785
0.02544
0.027397
0.029354
0.013699
0.02544
0.046967
0.039139
0
0.019569
0.02544
0.021526
0.033268
0.041096
0.039139
0.084149
0.046967
0.039139
0.099804
0.011742
0.050881
0.013699
0.035225
0.043053
0.056751
0.041096
0.017613
0.005871
0.013699
1
7,638
C
C
G
C
C
A
G
C
C
C
C
G
C
C
G
A
G
C
A
C
A
T
G
T
G
C
G
C
A
G
C
G
C
G
C
G
T
A
G
A
C
A
C
G
C
T
C
T
C
G
C
A
G
G
C
G
C
G
G
C
G
C
A
C
G
A
0.013699
0.009785
0.023483
0.005871
0.023483
0.02544
0.027397
0.011742
0.027397
0.052838
0.041096
0
0.019569
0.021526
0.021526
0.029354
0.041096
0.039139
0.086106
0.050881
0.037182
0.099804
0.011742
0.056751
0.013699
0.033268
0.037182
0.060665
0.04501
0.015656
0.003914
0.013699
1
7,639
C
T
T
T
G
C
A
C
C
C
A
C
C
C
T
C
C
T
C
C
T
C
C
G
C
A
C
A
C
C
T
C
T
C
C
A
C
C
T
G
C
G
A
C
A
C
G
A
A
G
C
G
C
G
T
C
T
C
G
A
A
G
G
C
T
C
0.007828
0.003914
0.019569
0.003914
0.017613
0.02544
0.023483
0.015656
0.011742
0.043053
0.07045
0.005871
0.005871
0.019569
0.009785
0.043053
0.056751
0.043053
0.117417
0.052838
0.02544
0.050881
0.007828
0.058708
0.015656
0.027397
0.050881
0.086106
0.052838
0.007828
0.001957
0.017613
1
7,640
T
T
T
G
C
A
C
C
C
A
C
C
C
T
C
C
T
C
C
T
C
C
G
C
A
C
A
C
C
T
C
T
C
C
A
C
C
T
G
C
G
A
C
A
C
G
A
A
G
C
G
C
G
T
C
T
C
G
A
A
G
G
C
T
C
T
0.007828
0.003914
0.019569
0.003914
0.017613
0.02544
0.023483
0.015656
0.011742
0.043053
0.07045
0.005871
0.005871
0.019569
0.009785
0.043053
0.054795
0.043053
0.117417
0.052838
0.02544
0.050881
0.007828
0.058708
0.015656
0.027397
0.050881
0.088063
0.052838
0.007828
0.001957
0.017613
1
7,641
T
G
T
G
C
T
G
C
T
C
A
G
G
C
T
C
G
T
G
G
A
C
G
A
A
A
A
C
C
T
G
C
T
C
T
T
C
C
A
C
G
G
G
G
A
G
G
C
C
T
C
C
G
A
G
C
A
G
C
T
G
C
G
C
A
A
0.009785
0.007828
0.019569
0.005871
0.015656
0.02544
0.031311
0.019569
0.015656
0.046967
0.058708
0.005871
0.009785
0.021526
0.007828
0.052838
0.054795
0.048924
0.109589
0.043053
0.02544
0.04501
0.007828
0.058708
0.019569
0.023483
0.050881
0.074364
0.048924
0.007828
0.005871
0.021526
1
7,642
G
G
G
C
G
A
G
C
T
G
G
T
G
C
G
G
C
T
T
G
T
G
C
T
G
C
T
C
A
G
G
C
T
C
G
T
G
G
A
C
G
A
A
A
A
C
C
T
G
C
T
C
T
T
C
C
A
C
G
G
G
G
A
G
G
C
0.013699
0.007828
0.021526
0.007828
0.015656
0.02544
0.031311
0.017613
0.017613
0.048924
0.058708
0.005871
0.011742
0.023483
0.007828
0.048924
0.054795
0.046967
0.099804
0.041096
0.02544
0.043053
0.009785
0.056751
0.021526
0.02544
0.050881
0.072407
0.048924
0.007828
0.007828
0.023483
1
7,643
G
A
G
C
C
T
G
A
G
C
A
G
C
A
C
A
A
G
C
C
G
C
A
C
C
A
G
C
T
C
G
C
C
C
A
T
G
T
A
C
T
T
G
C
C
A
C
C
T
A
T
G
A
G
C
T
T
C
T
C
A
T
A
C
C
G
0.013699
0.011742
0.023483
0.009785
0.015656
0.02544
0.039139
0.019569
0.017613
0.048924
0.060665
0.005871
0.013699
0.023483
0.011742
0.052838
0.054795
0.04501
0.084149
0.031311
0.02544
0.037182
0.011742
0.056751
0.023483
0.027397
0.052838
0.060665
0.048924
0.007828
0.009785
0.029354
1
7,644
C
C
A
T
G
T
A
C
T
T
G
C
C
A
C
C
T
A
T
G
A
G
C
T
T
C
T
C
A
T
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C
C
T
G
G
A
C
A
T
A
G
G
G
C
A
G
G
T
C
C
A
T
T
A
C
A
T
C
A
G
C
A
G
G
G
0.013699
0.011742
0.02544
0.009785
0.015656
0.02544
0.039139
0.021526
0.017613
0.050881
0.058708
0.005871
0.009785
0.021526
0.015656
0.054795
0.056751
0.046967
0.080235
0.029354
0.02544
0.033268
0.007828
0.058708
0.021526
0.027397
0.058708
0.064579
0.04501
0.007828
0.009785
0.029354
1
7,645
C
C
A
T
G
T
A
C
T
T
G
C
C
A
C
C
T
A
T
G
A
G
C
T
T
C
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C
A
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A
C
C
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G
G
A
C
A
T
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G
G
C
A
G
G
T
C
C
A
T
T
A
C
A
T
C
A
G
C
A
G
G
T
0.013699
0.011742
0.02544
0.009785
0.015656
0.02544
0.039139
0.021526
0.017613
0.050881
0.058708
0.005871
0.009785
0.021526
0.015656
0.054795
0.056751
0.046967
0.080235
0.029354
0.02544
0.033268
0.007828
0.058708
0.021526
0.027397
0.058708
0.064579
0.04501
0.007828
0.009785
0.029354
1
7,646
G
A
G
T
T
C
C
T
G
C
T
G
G
A
G
T
A
T
G
A
C
C
G
C
C
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G
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G
A
C
G
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C
T
C
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C
A
A
A
C
C
C
C
G
G
T
C
A
G
C
A
G
C
T
G
T
A
G
0.017613
0.021526
0.017613
0.011742
0.027397
0.027397
0.013699
0.02544
0.029354
0.048924
0.046967
0.007828
0.017613
0.037182
0.019569
0.027397
0.068493
0.048924
0.091977
0.035225
0.017613
0.019569
0.005871
0.058708
0.017613
0.031311
0.052838
0.050881
0.054795
0.011742
0.013699
0.023483
1
7,647
G
C
G
G
T
C
A
T
A
C
T
C
C
A
G
C
A
G
G
A
A
C
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C
G
T
C
C
A
G
C
T
C
G
C
C
G
G
A
G
T
C
C
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G
A
A
G
G
C
G
C
C
C
C
A
C
T
C
G
G
T
A
T
T
0.019569
0.019569
0.017613
0.013699
0.027397
0.023483
0.013699
0.021526
0.033268
0.050881
0.048924
0.005871
0.013699
0.037182
0.021526
0.023483
0.07045
0.050881
0.088063
0.037182
0.017613
0.021526
0.003914
0.062622
0.019569
0.031311
0.054795
0.052838
0.056751
0.011742
0.009785
0.019569
1
7,648
C
A
G
C
A
G
G
A
A
C
T
C
G
T
C
C
A
G
C
T
C
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C
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C
T
C
G
G
T
A
T
T
G
A
C
G
C
A
C
A
T
G
C
G
0.019569
0.019569
0.017613
0.013699
0.027397
0.02544
0.013699
0.021526
0.031311
0.052838
0.046967
0.005871
0.011742
0.035225
0.021526
0.021526
0.072407
0.052838
0.091977
0.037182
0.017613
0.021526
0.003914
0.058708
0.019569
0.033268
0.054795
0.054795
0.058708
0.011742
0.009785
0.015656
1
7,649
C
A
G
C
T
C
G
C
C
G
G
A
G
T
C
C
C
C
G
A
A
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C
G
G
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G
A
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C
A
C
A
T
G
C
G
G
C
C
C
T
C
G
T
C
C
C
C
C
T
T
0.019569
0.021526
0.019569
0.013699
0.02544
0.02544
0.013699
0.023483
0.031311
0.054795
0.04501
0.005871
0.011742
0.031311
0.023483
0.023483
0.072407
0.054795
0.09002
0.037182
0.017613
0.021526
0.003914
0.058708
0.021526
0.031311
0.054795
0.052838
0.058708
0.011742
0.009785
0.013699
1
7,650
C
C
C
G
A
A
G
G
C
G
C
C
C
C
A
C
T
C
G
G
T
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C
C
C
C
T
C
C
A
C
C
A
G
C
T
C
C
A
C
A
T
C
0.021526
0.021526
0.019569
0.013699
0.027397
0.02544
0.013699
0.021526
0.029354
0.056751
0.04501
0.005871
0.009785
0.031311
0.023483
0.023483
0.072407
0.058708
0.09002
0.037182
0.017613
0.021526
0.003914
0.056751
0.019569
0.031311
0.052838
0.056751
0.058708
0.011742
0.009785
0.011742
1
7,651
C
T
G
C
T
A
C
A
T
G
G
A
G
G
A
G
A
T
G
C
A
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C
G
A
G
G
G
C
C
G
C
A
T
G
T
G
C
G
T
C
A
C
0.023483
0.021526
0.019569
0.011742
0.029354
0.02544
0.009785
0.021526
0.031311
0.054795
0.050881
0.005871
0.007828
0.029354
0.021526
0.023483
0.074364
0.056751
0.091977
0.035225
0.015656
0.021526
0.005871
0.056751
0.021526
0.031311
0.052838
0.058708
0.058708
0.009785
0.009785
0.011742
1
7,652
C
C
C
C
T
C
C
A
C
C
A
G
C
T
C
C
A
C
A
T
T
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C
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C
A
T
T
G
C
A
G
C
C
C
G
T
G
C
C
T
G
G
G
G
T
0.017613
0.019569
0.019569
0.011742
0.031311
0.027397
0.009785
0.019569
0.029354
0.052838
0.056751
0.005871
0.007828
0.029354
0.019569
0.02544
0.078278
0.054795
0.09002
0.035225
0.015656
0.021526
0.005871
0.054795
0.021526
0.031311
0.052838
0.060665
0.058708
0.011742
0.011742
0.011742
1
7,653
C
C
C
G
A
C
C
T
C
C
A
C
C
C
C
A
G
G
C
A
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G
G
A
G
A
T
G
C
A
G
A
A
T
G
T
G
G
A
G
C
A
0.009785
0.019569
0.017613
0.011742
0.031311
0.029354
0.009785
0.019569
0.029354
0.050881
0.060665
0.005871
0.007828
0.029354
0.017613
0.02544
0.080235
0.054795
0.09002
0.035225
0.015656
0.021526
0.007828
0.054795
0.021526
0.031311
0.054795
0.062622
0.058708
0.013699
0.009785
0.011742
1
7,654
G
C
T
G
A
C
A
G
T
C
C
C
C
C
C
G
A
C
C
T
C
C
A
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G
G
C
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C
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A
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C
C
T
G
C
T
A
C
A
T
G
G
A
G
G
A
G
A
T
G
C
T
0.009785
0.021526
0.017613
0.009785
0.031311
0.033268
0.009785
0.019569
0.027397
0.050881
0.062622
0.003914
0.005871
0.027397
0.019569
0.027397
0.078278
0.056751
0.09002
0.035225
0.015656
0.021526
0.009785
0.056751
0.021526
0.031311
0.050881
0.060665
0.060665
0.013699
0.007828
0.011742
1
7,655
T
A
C
G
A
A
G
A
C
C
A
T
C
A
G
T
G
C
G
A
G
G
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C
T
C
C
T
T
G
C
A
C
C
C
C
T
G
C
C
C
C
T
T
G
0.011742
0.013699
0.039139
0.011742
0.033268
0.046967
0.017613
0.017613
0.029354
0.043053
0.052838
0.009785
0.029354
0.041096
0.027397
0.054795
0.062622
0.058708
0.064579
0.015656
0.013699
0.007828
0.011742
0.027397
0.031311
0.019569
0.058708
0.050881
0.029354
0.027397
0.005871
0.035225
1
7,656
G
G
G
G
T
G
C
A
A
G
G
A
G
C
C
C
T
T
A
C
C
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A
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C
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C
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G
A
T
G
G
T
C
T
T
C
G
T
A
G
T
A
G
C
A
G
G
T
0.011742
0.013699
0.039139
0.011742
0.033268
0.04501
0.017613
0.017613
0.029354
0.04501
0.052838
0.009785
0.029354
0.039139
0.027397
0.052838
0.066536
0.056751
0.062622
0.015656
0.013699
0.007828
0.011742
0.027397
0.031311
0.019569
0.060665
0.050881
0.031311
0.027397
0.005871
0.035225
1
7,657
C
A
A
G
G
A
G
C
C
C
T
T
A
C
C
C
A
C
G
A
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C
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C
T
T
C
G
T
A
G
T
A
G
C
A
G
G
A
G
A
T
C
A
T
0.011742
0.013699
0.041096
0.011742
0.033268
0.043053
0.017613
0.017613
0.029354
0.04501
0.056751
0.007828
0.027397
0.039139
0.027397
0.050881
0.066536
0.054795
0.062622
0.015656
0.013699
0.007828
0.011742
0.029354
0.031311
0.019569
0.060665
0.054795
0.029354
0.027397
0.005871
0.035225
1
7,658
T
C
A
T
G
C
C
G
A
C
C
T
C
G
C
A
C
T
G
A
T
G
G
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C
G
T
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G
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C
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A
G
A
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C
A
T
C
G
T
G
G
C
C
A
C
C
G
T
G
T
C
A
T
T
C
C
0.011742
0.015656
0.04501
0.011742
0.033268
0.043053
0.017613
0.019569
0.027397
0.043053
0.058708
0.003914
0.02544
0.033268
0.033268
0.050881
0.062622
0.054795
0.064579
0.015656
0.013699
0.007828
0.011742
0.029354
0.033268
0.021526
0.054795
0.054795
0.031311
0.02544
0.005871
0.039139
1
7,659
G
G
T
G
G
C
A
A
T
G
G
T
G
A
A
T
G
A
C
A
C
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T
G
G
C
C
A
C
G
A
T
G
A
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C
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C
C
T
G
C
T
A
C
T
A
C
G
A
A
G
A
C
C
A
T
C
A
G
T
G
C
G
A
0.011742
0.015656
0.046967
0.009785
0.031311
0.043053
0.017613
0.019569
0.029354
0.043053
0.060665
0.003914
0.02544
0.031311
0.033268
0.050881
0.060665
0.054795
0.066536
0.015656
0.013699
0.007828
0.011742
0.031311
0.033268
0.021526
0.052838
0.056751
0.031311
0.02544
0.005871
0.037182
1
7,660
G
A
A
C
A
A
T
G
T
C
G
T
G
G
G
G
C
T
T
C
T
G
C
G
A
G
A
C
G
C
T
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C
A
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G
G
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G
G
T
G
A
G
G
G
G
G
C
A
C
C
T
G
T
A
C
C
C
0.021526
0.013699
0.041096
0.009785
0.023483
0.033268
0.017613
0.019569
0.031311
0.04501
0.07045
0.015656
0.021526
0.027397
0.02544
0.04501
0.062622
0.048924
0.068493
0.009785
0.017613
0.005871
0.019569
0.043053
0.033268
0.017613
0.056751
0.060665
0.035225
0.019569
0.007828
0.031311
1
7,661
C
A
G
G
T
G
C
C
C
C
C
T
C
A
C
C
C
C
T
C
T
C
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G
T
T
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G
A
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C
G
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C
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C
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C
C
C
C
A
C
G
A
C
A
T
T
G
T
T
C
C
C
T
T
T
0.021526
0.013699
0.043053
0.009785
0.023483
0.033268
0.017613
0.019569
0.031311
0.04501
0.07045
0.017613
0.023483
0.027397
0.02544
0.04501
0.060665
0.046967
0.068493
0.009785
0.017613
0.005871
0.019569
0.043053
0.033268
0.015656
0.056751
0.060665
0.035225
0.019569
0.007828
0.031311
1
7,662
T
C
T
C
C
G
T
T
T
G
A
T
A
G
C
G
T
C
T
C
G
C
A
G
A
A
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C
C
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C
A
C
G
A
C
A
T
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G
T
T
C
C
C
T
T
C
T
G
C
T
C
C
T
G
A
G
G
C
C
T
T
G
A
T
0.023483
0.013699
0.039139
0.011742
0.023483
0.031311
0.017613
0.019569
0.033268
0.046967
0.068493
0.023483
0.02544
0.029354
0.023483
0.043053
0.062622
0.046967
0.062622
0.009785
0.017613
0.005871
0.019569
0.043053
0.033268
0.015656
0.054795
0.060665
0.033268
0.019569
0.007828
0.033268
1
7,663
C
C
T
T
C
T
G
C
T
C
C
T
G
A
G
G
C
C
T
T
G
A
A
G
C
C
C
T
T
G
G
T
C
C
A
G
T
T
G
A
G
A
A
G
G
A
T
G
C
C
C
T
G
T
G
G
G
G
A
G
A
G
A
T
A
G
0.02544
0.015656
0.037182
0.017613
0.029354
0.02544
0.015656
0.021526
0.035225
0.050881
0.062622
0.023483
0.019569
0.02544
0.027397
0.041096
0.07045
0.046967
0.060665
0.007828
0.011742
0.003914
0.019569
0.04501
0.035225
0.013699
0.054795
0.058708
0.033268
0.021526
0.009785
0.033268
1
7,664
C
A
A
G
C
A
T
C
A
G
A
T
G
A
A
A
C
A
C
A
A
G
A
A
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C
T
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C
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C
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C
A
C
C
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C
T
C
C
T
T
T
C
C
T
G
T
G
A
G
G
C
A
C
G
C
0.013699
0.009785
0.043053
0.019569
0.039139
0.023483
0.005871
0.013699
0.043053
0.048924
0.058708
0.007828
0.02544
0.04501
0.021526
0.050881
0.062622
0.054795
0.052838
0.013699
0.011742
0.011742
0.015656
0.043053
0.041096
0.015656
0.050881
0.068493
0.037182
0.005871
0.009785
0.035225
1
7,665
T
G
G
T
G
A
A
G
G
T
G
G
G
A
G
A
A
G
G
T
G
A
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G
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G
G
G
C
A
G
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G
G
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G
C
G
T
G
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A
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A
C
C
A
A
A
C
A
C
C
A
G
A
T
G
T
A
C
T
C
C
C
0.005871
0.007828
0.031311
0.001957
0.035225
0.04501
0.005871
0.027397
0.029354
0.035225
0.074364
0.003914
0.013699
0.019569
0.015656
0.056751
0.074364
0.072407
0.091977
0.019569
0.003914
0.009785
0.011742
0.050881
0.017613
0.041096
0.027397
0.064579
0.056751
0.007828
0.007828
0.033268
1
7,666
A
G
T
G
C
C
A
C
C
C
A
G
G
T
C
C
A
G
G
G
A
G
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G
G
A
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C
C
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A
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G
C
A
C
A
G
A
G
A
G
A
A
G
T
G
T
G
T
C
A
G
G
0.013699
0.009785
0.035225
0.003914
0.031311
0.046967
0.005871
0.031311
0.029354
0.029354
0.074364
0.003914
0.013699
0.017613
0.019569
0.054795
0.068493
0.064579
0.09002
0.021526
0.005871
0.009785
0.011742
0.048924
0.021526
0.04501
0.027397
0.054795
0.056751
0.007828
0.007828
0.037182
1
7,667
T
G
T
G
G
T
A
C
C
T
G
A
G
C
C
T
T
C
T
G
G
G
G
T
G
G
A
G
C
G
C
A
C
G
T
A
G
G
T
G
G
G
C
A
G
C
A
T
C
T
T
C
A
C
A
C
T
G
G
C
C
T
C
T
T
T
0.011742
0.011742
0.021526
0.005871
0.017613
0.041096
0.009785
0.019569
0.041096
0.052838
0.066536
0
0.023483
0.02544
0.007828
0.041096
0.080235
0.062622
0.082192
0.023483
0.011742
0.009785
0.009785
0.068493
0.02544
0.023483
0.043053
0.058708
0.052838
0.011742
0.005871
0.033268
1
7,668
C
C
T
T
C
T
G
G
G
G
T
G
G
A
G
C
G
C
A
C
G
T
A
G
G
T
G
G
G
C
A
G
C
A
T
C
T
T
C
A
C
A
C
T
G
G
C
C
T
C
T
T
C
A
T
G
G
G
T
C
T
C
C
A
G
A
0.005871
0.009785
0.021526
0.003914
0.017613
0.041096
0.009785
0.019569
0.041096
0.052838
0.068493
0
0.021526
0.029354
0.007828
0.043053
0.078278
0.064579
0.084149
0.023483
0.011742
0.009785
0.009785
0.07045
0.02544
0.023483
0.043053
0.062622
0.052838
0.011742
0.001957
0.033268
1
7,669
A
G
G
T
G
A
T
G
A
G
A
C
G
G
A
T
G
C
A
G
A
A
G
G
A
G
A
T
G
G
A
C
C
G
C
G
G
C
C
T
G
A
G
G
C
T
G
G
A
G
A
C
C
C
A
T
G
A
A
G
A
G
G
C
C
T
0
0.005871
0.027397
0.003914
0.019569
0.043053
0.009785
0.015656
0.050881
0.046967
0.066536
0
0.02544
0.033268
0.007828
0.039139
0.078278
0.060665
0.086106
0.02544
0.009785
0.009785
0.009785
0.064579
0.029354
0.031311
0.039139
0.056751
0.052838
0.011742
0.001957
0.037182
1
7,670
A
T
G
G
G
T
C
T
C
C
A
G
C
C
T
C
A
G
G
C
C
G
C
G
G
T
C
C
A
T
C
T
C
C
T
T
C
T
G
C
A
T
C
C
G
T
C
T
C
A
T
C
A
C
C
T
T
C
T
T
C
A
G
G
T
T
0.003914
0.007828
0.029354
0.003914
0.019569
0.043053
0.009785
0.019569
0.050881
0.046967
0.064579
0
0.02544
0.033268
0.007828
0.039139
0.076321
0.060665
0.084149
0.021526
0.009785
0.009785
0.011742
0.064579
0.029354
0.029354
0.039139
0.052838
0.050881
0.013699
0.003914
0.037182
1
7,671
T
T
G
A
A
C
T
T
T
T
T
C
A
G
A
C
A
C
T
C
C
A
C
A
G
T
C
T
C
C
T
G
T
C
T
G
T
G
C
A
T
C
A
T
G
G
A
T
G
C
T
A
C
C
G
T
G
G
A
G
C
G
T
T
G
A
0.009785
0.013699
0.033268
0.007828
0.029354
0.031311
0.009785
0.033268
0.039139
0.031311
0.060665
0.003914
0.007828
0.027397
0.033268
0.043053
0.072407
0.072407
0.093933
0.015656
0.007828
0.005871
0.011742
0.046967
0.017613
0.043053
0.048924
0.07045
0.04501
0.003914
0.003914
0.02544
1
7,672
G
T
T
T
T
T
G
G
C
T
T
C
A
G
G
A
G
T
G
A
C
G
G
T
G
T
C
C
C
A
C
T
C
A
G
G
G
G
A
C
G
G
G
A
A
C
T
G
C
A
G
A
A
G
G
A
A
A
C
A
G
C
G
C
C
T
0.007828
0.011742
0.035225
0.005871
0.015656
0.04501
0.015656
0.013699
0.035225
0.043053
0.074364
0.001957
0.021526
0.02544
0.02544
0.050881
0.064579
0.068493
0.086106
0.017613
0.003914
0.013699
0.005871
0.060665
0.027397
0.027397
0.035225
0.062622
0.052838
0
0
0.04501
1
7,673
G
A
T
C
C
T
G
T
A
C
A
T
C
C
T
G
C
T
C
G
T
G
G
G
C
T
A
C
C
C
A
C
C
C
T
T
C
T
G
G
G
A
C
G
A
G
G
A
C
C
A
G
C
A
C
A
A
G
C
T
G
T
A
C
C
T
0.001957
0
0.027397
0.009785
0.027397
0.04501
0.013699
0.011742
0.027397
0.050881
0.076321
0.003914
0.021526
0.023483
0.013699
0.068493
0.074364
0.060665
0.091977
0.019569
0.005871
0.005871
0.015656
0.048924
0.023483
0.017613
0.054795
0.068493
0.043053
0.011742
0
0.035225
1
7,674
G
T
G
A
G
G
G
C
T
C
T
G
C
A
C
C
C
A
C
C
T
G
G
C
A
T
C
A
G
C
C
T
C
G
C
T
G
T
A
G
T
A
C
T
C
T
C
T
C
G
C
C
A
C
A
A
T
G
T
C
T
T
C
A
A
T
0.009785
0.009785
0.027397
0.011742
0.027397
0.07045
0.009785
0.023483
0.035225
0.037182
0.050881
0.009785
0.035225
0.04501
0.017613
0.082192
0.050881
0.084149
0.054795
0.001957
0.005871
0.013699
0.013699
0.052838
0.019569
0.021526
0.029354
0.033268
0.033268
0.017613
0.009785
0.054795
1
7,675
T
G
A
G
T
C
T
G
A
C
C
T
C
G
A
C
A
A
G
G
T
C
T
T
C
C
A
C
T
T
G
C
C
C
A
C
C
A
C
C
A
C
T
T
T
C
A
T
C
G
G
G
G
G
A
C
A
G
G
A
A
T
C
A
G
T
0.084149
0.019569
0.04501
0.027397
0.031311
0.019569
0.001957
0.035225
0.048924
0.031311
0.043053
0.037182
0.027397
0.029354
0.023483
0.029354
0.056751
0.043053
0.039139
0.007828
0.009785
0.003914
0.021526
0.035225
0.041096
0.029354
0.033268
0.033268
0.041096
0.009785
0.027397
0.033268
1
7,676
G
A
T
C
C
C
T
G
C
C
C
T
C
A
A
G
A
C
C
A
T
C
A
T
T
G
A
C
A
A
G
T
C
T
A
G
T
G
A
G
A
A
T
G
G
C
G
T
G
G
A
C
T
A
C
G
T
G
A
T
C
A
T
G
G
A
0.021526
0.015656
0.035225
0.015656
0.031311
0.046967
0.005871
0.027397
0.037182
0.033268
0.074364
0.001957
0.023483
0.029354
0.037182
0.043053
0.066536
0.058708
0.035225
0.003914
0.007828
0.017613
0.013699
0.058708
0.02544
0.029354
0.037182
0.046967
0.043053
0.023483
0.003914
0.048924
1
7,677
A
G
A
A
A
C
C
A
G
G
T
T
G
G
G
C
G
C
G
C
C
C
T
T
G
G
C
T
G
T
A
C
C
T
G
T
G
T
G
G
C
A
T
G
C
C
C
A
T
G
A
T
C
A
C
G
T
A
G
T
C
C
A
C
G
T
0.027397
0.015656
0.039139
0.017613
0.037182
0.041096
0.005871
0.031311
0.037182
0.029354
0.068493
0.001957
0.021526
0.037182
0.039139
0.04501
0.062622
0.060665
0.033268
0.001957
0.001957
0.017613
0.015656
0.048924
0.02544
0.027397
0.041096
0.048924
0.041096
0.027397
0.005871
0.04501
1
7,678
A
G
A
A
G
A
T
C
T
G
T
T
C
C
A
G
C
T
C
C
T
T
C
C
T
G
A
T
G
A
C
A
T
T
T
G
C
A
A
G
C
A
C
G
T
T
C
A
G
C
C
G
C
C
C
T
C
T
G
G
A
A
C
G
T
C
0.023483
0.02544
0.035225
0.02544
0.035225
0.033268
0.013699
0.015656
0.043053
0.043053
0.050881
0.009785
0.027397
0.035225
0.037182
0.037182
0.056751
0.056751
0.062622
0.011742
0.009785
0.003914
0.015656
0.04501
0.035225
0.019569
0.043053
0.04501
0.043053
0.015656
0.013699
0.031311
1
7,679
C
A
C
C
T
T
C
T
T
G
C
C
C
T
T
C
T
T
G
C
C
C
T
C
C
T
C
T
T
C
C
A
T
A
T
C
G
C
C
G
C
G
T
G
C
G
G
C
T
C
C
C
G
C
G
G
C
C
C
G
C
C
C
G
G
C
0.005871
0.005871
0.027397
0.001957
0.011742
0.02544
0.007828
0.009785
0.011742
0.039139
0.039139
0.003914
0.003914
0.009785
0.013699
0.029354
0.037182
0.041096
0.16047
0.111546
0.019569
0.103718
0.003914
0.031311
0.021526
0.015656
0.02544
0.136986
0.029354
0.003914
0
0.011742
1
7,680
T
G
G
G
C
C
C
G
T
G
G
A
G
G
C
A
T
G
C
T
G
C
C
T
G
G
T
C
A
T
C
C
T
G
G
C
T
G
C
A
G
A
G
A
G
C
A
A
G
G
T
G
A
G
A
C
T
T
T
C
T
C
G
C
C
G
0.011742
0.017613
0.017613
0.003914
0.023483
0.029354
0.003914
0.037182
0.041096
0.04501
0.066536
0
0.009785
0.029354
0.013699
0.046967
0.097847
0.07045
0.076321
0.007828
0.005871
0.009785
0.007828
0.064579
0.019569
0.023483
0.062622
0.074364
0.039139
0.005871
0.005871
0.031311
1
7,681
G
A
C
T
G
T
C
C
A
G
G
T
C
G
G
C
G
T
G
A
C
A
G
C
C
G
G
C
G
C
T
C
C
G
T
G
G
C
A
G
T
G
C
G
C
G
C
C
C
T
G
C
T
C
C
G
C
C
G
A
G
A
A
G
C
T
0.001957
0.009785
0.005871
0
0.015656
0.029354
0.021526
0.019569
0.029354
0.054795
0.033268
0
0.015656
0.015656
0.013699
0.041096
0.072407
0.048924
0.048924
0.078278
0.02544
0.113503
0
0.056751
0.001957
0.031311
0.064579
0.09589
0.035225
0.003914
0
0.015656
1
7,682
T
G
G
G
C
G
C
C
G
C
G
T
G
C
G
G
C
G
T
G
G
C
G
A
C
T
G
C
A
C
G
C
T
G
C
G
C
C
C
G
G
G
G
A
C
T
C
A
G
T
T
G
C
C
G
C
G
C
G
C
T
G
C
C
G
G
0.001957
0.013699
0.007828
0
0.019569
0.029354
0.021526
0.023483
0.021526
0.056751
0.04501
0
0.003914
0.007828
0.015656
0.037182
0.078278
0.031311
0.076321
0.074364
0.017613
0.097847
0.007828
0.052838
0.003914
0.033268
0.074364
0.080235
0.039139
0.009785
0.001957
0.015656
1
7,683
C
C
C
C
G
G
A
A
T
G
C
A
G
C
T
T
G
A
T
G
T
G
C
C
G
G
A
G
C
A
G
G
T
T
G
C
C
C
T
T
C
T
G
G
G
T
G
A
A
T
G
A
G
G
C
C
C
C
G
C
A
C
T
G
A
C
0.02544
0.02544
0.021526
0.021526
0.019569
0.031311
0.019569
0.029354
0.029354
0.041096
0.052838
0.001957
0.021526
0.021526
0.023483
0.037182
0.064579
0.039139
0.062622
0.04501
0.007828
0.017613
0.015656
0.050881
0.031311
0.031311
0.048924
0.046967
0.058708
0.005871
0.011742
0.039139
1
7,684
A
G
G
G
C
T
T
C
T
C
C
C
C
G
G
A
A
T
G
C
A
G
C
T
T
G
A
T
G
T
G
C
C
G
G
A
G
C
A
G
G
T
T
G
C
C
C
T
T
C
T
G
G
G
T
G
A
A
T
G
A
G
G
C
C
T
0.021526
0.02544
0.02544
0.017613
0.019569
0.031311
0.019569
0.029354
0.029354
0.043053
0.052838
0.001957
0.019569
0.021526
0.02544
0.037182
0.064579
0.039139
0.062622
0.04501
0.007828
0.017613
0.013699
0.050881
0.033268
0.033268
0.048924
0.046967
0.058708
0.005871
0.009785
0.041096
1
7,685
A
G
A
G
G
T
G
G
C
A
T
T
T
G
A
A
G
G
G
C
T
T
C
T
C
C
C
C
G
G
A
A
T
G
C
A
G
C
T
T
G
A
T
G
T
G
C
C
G
G
A
G
C
A
G
G
T
T
G
C
C
C
T
T
C
C
0.015656
0.02544
0.02544
0.013699
0.021526
0.031311
0.019569
0.029354
0.027397
0.043053
0.052838
0.001957
0.017613
0.02544
0.023483
0.037182
0.062622
0.041096
0.072407
0.04501
0.007828
0.017613
0.013699
0.050881
0.031311
0.033268
0.050881
0.048924
0.060665
0.005871
0.009785
0.037182
1
7,686
G
C
C
C
C
G
G
A
C
T
G
C
A
T
C
C
A
G
G
G
G
A
C
C
T
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C
C
G
G
A
G
T
G
C
G
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C
C
T
C
A
G
G
T
G
G
C
C
A
G
T
G
A
G
G
G
C
G
T
C
C
C
T
C
C
0.013699
0.017613
0.023483
0.017613
0.029354
0.029354
0.017613
0.027397
0.031311
0.031311
0.054795
0.005871
0.017613
0.029354
0.023483
0.04501
0.056751
0.043053
0.088063
0.041096
0.007828
0.019569
0.009785
0.054795
0.029354
0.031311
0.054795
0.043053
0.066536
0.007828
0.003914
0.027397
1
7,687
C
T
T
T
A
T
G
T
T
C
C
T
C
T
A
A
A
G
A
G
C
T
T
C
G
C
T
G
T
T
T
A
T
A
G
C
T
T
C
G
G
C
C
A
C
A
A
T
A
T
C
C
A
C
A
T
T
T
G
T
G
A
G
G
T
C
0.07045
0.035225
0.046967
0.041096
0.031311
0.027397
0.011742
0.023483
0.029354
0.050881
0.041096
0.015656
0.003914
0.02544
0.04501
0.029354
0.043053
0.046967
0.043053
0.015656
0.007828
0.015656
0.017613
0.037182
0.039139
0.005871
0.04501
0.04501
0.031311
0.023483
0.037182
0.017613
1
7,688
C
G
G
C
C
G
C
C
A
G
C
T
C
T
T
T
G
A
T
G
T
G
T
T
C
C
C
A
G
G
C
C
C
G
C
T
G
C
A
C
A
T
G
G
G
C
A
G
A
T
T
C
C
A
C
C
G
T
G
C
G
A
G
A
A
G
0.041096
0.019569
0.039139
0.021526
0.035225
0.02544
0.011742
0.027397
0.043053
0.043053
0.052838
0.003914
0.015656
0.02544
0.033268
0.039139
0.066536
0.046967
0.033268
0.023483
0.007828
0.015656
0.009785
0.050881
0.037182
0.02544
0.048924
0.050881
0.046967
0.015656
0.009785
0.033268
1
7,689
G
T
G
T
G
G
A
A
G
T
C
A
T
T
C
T
G
G
G
G
C
T
T
G
T
C
T
G
C
T
T
T
C
G
G
C
T
A
A
A
G
G
T
T
T
G
T
C
T
A
C
A
T
C
T
A
T
T
C
C
A
T
T
C
T
T
0.056751
0.027397
0.04501
0.039139
0.043053
0.015656
0.005871
0.027397
0.046967
0.04501
0.031311
0.011742
0.011742
0.048924
0.029354
0.029354
0.056751
0.046967
0.027397
0.015656
0.001957
0.015656
0.021526
0.029354
0.054795
0.021526
0.037182
0.046967
0.031311
0.013699
0.027397
0.037182
1
7,690
A
A
A
T
C
T
G
T
G
T
G
G
A
A
G
T
C
A
T
T
C
T
G
G
G
G
C
T
T
G
T
C
T
G
C
T
T
T
C
G
G
C
T
A
A
A
G
G
T
T
T
G
T
C
T
A
C
A
T
C
T
A
T
T
C
G
0.056751
0.027397
0.046967
0.037182
0.043053
0.015656
0.005871
0.027397
0.04501
0.046967
0.033268
0.011742
0.011742
0.048924
0.029354
0.029354
0.054795
0.046967
0.027397
0.015656
0.001957
0.013699
0.023483
0.029354
0.052838
0.021526
0.035225
0.048924
0.031311
0.013699
0.029354
0.037182
1