row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
f_7_ref__25
string
f_8_ref__24
string
f_9_ref__23
string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
f_14_ref__18
string
f_15_ref__17
string
f_16_ref__16
string
f_17_ref__15
string
f_18_ref__14
string
f_19_ref__13
string
f_20_ref__12
string
f_21_ref__11
string
f_22_ref__10
string
f_23_ref__9
string
f_24_ref__8
string
f_25_ref__7
string
f_26_ref__6
string
f_27_ref__5
string
f_28_ref__4
string
f_29_ref__3
string
f_30_ref__2
string
f_31_ref__1
string
f_32_ref_0
string
f_33_ref__1
string
f_34_ref__2
string
f_35_ref__3
string
f_36_ref__4
string
f_37_ref__5
string
f_38_ref__6
string
f_39_ref__7
string
f_40_ref__8
string
f_41_ref__9
string
f_42_ref__10
string
f_43_ref__11
string
f_44_ref__12
string
f_45_ref__13
string
f_46_ref__14
string
f_47_ref__15
string
f_48_ref__16
string
f_49_ref__17
string
f_50_ref__18
string
f_51_ref__19
string
f_52_ref__20
string
f_53_ref__21
string
f_54_ref__22
string
f_55_ref__23
string
f_56_ref__24
string
f_57_ref__25
string
f_58_ref__26
string
f_59_ref__27
string
f_60_ref__28
string
f_61_ref__29
string
f_62_ref__30
string
f_63_ref__31
string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
12,176
G
A
A
A
C
T
G
T
C
A
G
A
T
G
T
G
A
T
G
A
T
C
C
T
G
A
C
A
G
T
G
T
T
C
T
G
C
C
T
G
A
G
T
G
T
T
T
T
T
G
C
C
T
T
G
A
T
C
G
G
A
C
T
G
C
C
0.046967
0.023483
0.04501
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0.037182
0.021526
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0.017613
0.02544
0.04501
0.035225
0.011742
0.019569
0.046967
1
12,177
A
A
G
A
G
G
T
A
T
T
A
C
T
C
A
C
C
A
A
T
T
G
A
T
A
C
A
A
G
T
T
T
T
C
C
C
A
A
T
A
G
T
C
C
T
G
G
G
T
C
A
T
A
A
G
G
C
G
A
A
A
T
A
A
T
C
0.050881
0.033268
0.048924
0.04501
0.041096
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1
12,178
G
A
C
C
A
A
G
A
C
G
A
A
G
A
A
G
A
T
C
A
T
G
T
A
T
G
T
T
T
T
C
C
C
G
G
C
T
G
C
T
C
G
T
A
A
A
G
T
C
T
G
C
A
A
A
G
A
C
A
A
A
G
G
C
C
T
0.056751
0.037182
0.054795
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0.041096
0.029354
0.003914
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0.046967
0.021526
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0.041096
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0.043053
0.050881
0.023483
0.007828
0.003914
0
0.013699
0.02544
0.046967
0.019569
0.037182
0.035225
0.029354
0.023483
0.02544
0.041096
1
12,179
A
T
T
C
A
G
G
A
C
G
A
T
G
C
A
G
A
T
G
G
T
G
A
T
G
G
C
T
A
A
A
T
C
C
A
C
A
A
A
A
G
G
G
T
C
C
A
T
A
A
C
T
A
T
C
A
A
G
T
T
C
A
C
A
A
T
0.058708
0.031311
0.039139
0.041096
0.048924
0.021526
0.001957
0.043053
0.043053
0.023483
0.02544
0.037182
0.037182
0.041096
0.039139
0.039139
0.048924
0.054795
0.021526
0.003914
0.003914
0.005871
0.019569
0.027397
0.041096
0.019569
0.023483
0.021526
0.041096
0.02544
0.031311
0.039139
1
12,180
A
C
T
G
A
G
T
C
T
A
G
C
A
G
A
C
G
T
G
G
A
G
G
G
G
C
T
T
T
C
A
G
T
G
C
T
G
C
G
A
T
C
T
T
T
C
C
G
A
T
T
G
G
T
A
T
T
C
C
A
T
A
T
T
T
A
0.117417
0.035225
0.039139
0.076321
0.021526
0.011742
0.005871
0.033268
0.041096
0.033268
0.02544
0.048924
0.027397
0.031311
0.035225
0.007828
0.029354
0.029354
0.021526
0.005871
0.003914
0.003914
0.041096
0.023483
0.056751
0.009785
0.021526
0.007828
0.041096
0.019569
0.062622
0.031311
1
12,181
A
G
A
C
G
T
G
G
A
G
G
G
G
C
T
T
T
C
A
G
T
G
C
T
G
C
G
A
T
C
T
T
T
C
C
G
A
T
T
G
G
T
A
T
T
C
C
A
T
A
T
T
T
C
T
C
C
A
A
T
T
T
C
T
T
C
0.117417
0.033268
0.039139
0.080235
0.021526
0.009785
0.005871
0.031311
0.039139
0.037182
0.023483
0.048924
0.029354
0.033268
0.033268
0.007828
0.031311
0.029354
0.021526
0.005871
0.003914
0.003914
0.041096
0.019569
0.056751
0.009785
0.02544
0.007828
0.041096
0.019569
0.062622
0.029354
1
12,182
T
T
T
T
T
T
G
T
T
T
G
G
G
T
T
T
T
T
T
T
T
T
T
C
C
T
T
A
G
C
T
C
C
G
A
G
T
C
T
T
C
A
A
A
T
T
G
G
C
C
A
A
A
T
C
C
T
G
G
C
C
C
A
C
C
G
0.097847
0.02544
0.033268
0.064579
0.035225
0.017613
0.001957
0.037182
0.037182
0.023483
0.029354
0.029354
0.02544
0.033268
0.043053
0.031311
0.043053
0.04501
0.029354
0.005871
0.007828
0.003914
0.021526
0.029354
0.043053
0.02544
0.029354
0.02544
0.037182
0.009785
0.037182
0.041096
1
12,183
C
C
A
G
G
C
C
A
T
G
T
G
C
C
T
C
A
T
T
G
T
C
T
T
T
A
T
G
A
T
G
G
T
C
A
T
G
G
T
G
A
T
T
G
G
C
A
A
C
T
T
G
G
T
G
G
T
T
A
G
T
A
C
T
A
A
0.046967
0.027397
0.048924
0.029354
0.041096
0.031311
0.003914
0.04501
0.046967
0.011742
0.039139
0.019569
0.019569
0.048924
0.048924
0.035225
0.033268
0.054795
0.037182
0.005871
0.005871
0.003914
0.031311
0.031311
0.037182
0.031311
0.035225
0.035225
0.031311
0.027397
0.019569
0.035225
1
12,184
T
A
T
C
T
A
C
A
A
A
T
T
A
G
T
A
C
T
A
A
C
C
A
C
C
A
A
G
T
T
G
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
A
A
A
G
A
C
A
A
T
G
A
G
G
C
G
0.050881
0.027397
0.050881
0.029354
0.041096
0.029354
0.003914
0.046967
0.046967
0.013699
0.037182
0.019569
0.019569
0.048924
0.048924
0.035225
0.029354
0.052838
0.035225
0.005871
0.005871
0.003914
0.031311
0.033268
0.039139
0.031311
0.035225
0.033268
0.033268
0.027397
0.019569
0.033268
1
12,185
A
T
A
G
G
T
G
C
T
G
A
A
C
C
T
G
T
T
T
C
T
G
G
C
C
T
T
G
C
T
C
C
T
G
A
G
C
T
C
C
T
T
C
A
G
T
G
C
A
G
A
C
A
A
C
C
T
G
G
C
T
G
C
C
A
C
0.052838
0.041096
0.043053
0.021526
0.041096
0.037182
0.015656
0.031311
0.035225
0.027397
0.043053
0.017613
0.027397
0.037182
0.043053
0.046967
0.050881
0.054795
0.015656
0.009785
0.007828
0.005871
0.011742
0.031311
0.043053
0.017613
0.039139
0.037182
0.033268
0.017613
0.019569
0.043053
1
12,186
G
C
T
G
A
A
C
C
T
G
T
T
T
C
T
G
G
C
C
T
T
G
C
T
C
C
T
G
A
G
C
T
C
C
T
T
C
A
G
T
G
C
A
G
A
C
A
A
C
C
T
G
G
C
T
G
C
C
A
C
A
G
A
T
G
T
0.050881
0.041096
0.043053
0.023483
0.041096
0.037182
0.015656
0.029354
0.035225
0.027397
0.043053
0.013699
0.027397
0.039139
0.04501
0.046967
0.050881
0.056751
0.015656
0.009785
0.007828
0.005871
0.009785
0.031311
0.043053
0.017613
0.041096
0.039139
0.033268
0.017613
0.017613
0.043053
1
12,187
G
C
C
T
T
G
C
T
C
C
T
G
A
G
C
T
C
C
T
T
C
A
G
T
G
C
A
G
A
C
A
A
C
C
T
G
G
C
T
G
C
C
A
C
A
G
A
T
G
A
C
G
A
T
G
G
G
G
A
A
A
T
G
A
A
G
0.04501
0.043053
0.037182
0.023483
0.043053
0.037182
0.015656
0.029354
0.029354
0.029354
0.043053
0.013699
0.027397
0.041096
0.04501
0.048924
0.052838
0.058708
0.013699
0.011742
0.007828
0.007828
0.009785
0.029354
0.041096
0.015656
0.04501
0.043053
0.033268
0.017613
0.017613
0.043053
1
12,188
T
T
A
C
C
C
T
C
A
T
C
C
C
T
T
C
A
A
A
T
C
G
T
G
A
T
A
A
G
G
C
T
C
T
T
A
A
G
G
G
T
C
T
C
A
A
A
G
C
T
C
T
T
A
G
G
G
T
C
C
T
A
A
G
G
G
0.121331
0.029354
0.043053
0.02544
0.033268
0.023483
0.007828
0.021526
0.050881
0.037182
0.041096
0.015656
0.033268
0.031311
0.02544
0.033268
0.04501
0.031311
0.050881
0.003914
0.007828
0.003914
0.031311
0.031311
0.035225
0.011742
0.041096
0.027397
0.02544
0.011742
0.039139
0.029354
1
12,189
C
C
C
T
A
A
G
A
G
C
T
T
T
G
A
G
A
C
C
C
T
T
A
A
G
A
G
C
C
T
T
A
T
C
A
C
G
A
T
T
T
G
A
A
G
G
G
A
T
G
A
G
G
G
T
A
A
G
A
T
A
C
T
A
A
C
0.121331
0.033268
0.043053
0.02544
0.037182
0.021526
0.007828
0.021526
0.048924
0.037182
0.037182
0.015656
0.033268
0.035225
0.02544
0.033268
0.04501
0.031311
0.050881
0.003914
0.007828
0.003914
0.029354
0.029354
0.035225
0.011742
0.041096
0.027397
0.023483
0.009785
0.043053
0.029354
1
12,190
G
G
G
G
A
T
G
G
C
G
C
C
C
A
C
C
A
A
G
G
C
A
T
T
C
A
C
C
A
C
C
A
C
C
T
G
C
A
T
T
G
G
A
A
G
G
G
G
A
G
G
T
T
G
C
T
C
A
G
T
G
T
T
G
G
T
0.066536
0.031311
0.04501
0.058708
0.048924
0.023483
0.003914
0.033268
0.035225
0.027397
0.029354
0.015656
0.027397
0.046967
0.050881
0.033268
0.037182
0.046967
0.029354
0.003914
0.001957
0.005871
0.019569
0.023483
0.052838
0.027397
0.021526
0.011742
0.043053
0.017613
0.029354
0.050881
1
12,191
C
A
A
C
A
C
T
G
A
G
C
A
A
C
C
T
C
C
C
C
T
T
C
C
A
A
T
G
C
A
G
G
T
G
G
T
G
G
T
G
A
A
T
G
C
C
T
T
G
G
T
G
G
G
C
G
C
C
A
T
C
C
C
C
T
C
0.066536
0.031311
0.043053
0.058708
0.048924
0.023483
0.003914
0.033268
0.035225
0.027397
0.029354
0.015656
0.027397
0.046967
0.050881
0.033268
0.037182
0.046967
0.031311
0.003914
0.001957
0.005871
0.019569
0.023483
0.052838
0.027397
0.021526
0.011742
0.043053
0.017613
0.029354
0.050881
1
12,192
T
C
A
T
G
A
T
G
G
A
G
G
G
G
A
T
G
G
C
G
C
C
C
A
C
C
A
A
G
G
C
A
T
T
C
A
C
C
A
C
C
A
C
C
T
G
C
A
T
T
G
G
A
A
G
G
G
G
A
G
G
T
T
G
C
C
0.066536
0.031311
0.043053
0.058708
0.048924
0.019569
0.003914
0.033268
0.033268
0.027397
0.027397
0.017613
0.029354
0.046967
0.050881
0.033268
0.039139
0.046967
0.033268
0.003914
0.001957
0.005871
0.015656
0.023483
0.052838
0.023483
0.023483
0.013699
0.04501
0.019569
0.029354
0.050881
1
12,193
T
G
G
T
G
G
G
C
G
C
C
A
T
C
C
C
C
T
C
C
A
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T
C
A
T
C
T
T
C
T
G
G
C
T
G
A
T
T
T
T
C
G
0.068493
0.033268
0.046967
0.052838
0.048924
0.019569
0.003914
0.039139
0.035225
0.021526
0.029354
0.015656
0.029354
0.046967
0.048924
0.033268
0.037182
0.04501
0.031311
0.003914
0.001957
0.005871
0.017613
0.023483
0.054795
0.021526
0.023483
0.015656
0.043053
0.02544
0.027397
0.048924
1
12,194
G
A
T
T
T
T
C
A
G
C
A
T
C
A
T
G
G
G
A
G
T
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T
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C
T
A
C
T
G
C
T
T
T
A
A
T
G
A
G
A
C
T
T
T
0.066536
0.035225
0.043053
0.050881
0.052838
0.017613
0.003914
0.033268
0.037182
0.029354
0.02544
0.009785
0.031311
0.048924
0.050881
0.035225
0.04501
0.046967
0.033268
0.003914
0.001957
0.005871
0.011742
0.023483
0.060665
0.015656
0.027397
0.019569
0.039139
0.021526
0.019569
0.052838
1
12,195
T
T
T
C
T
T
T
T
G
T
T
G
A
T
T
G
A
A
G
T
T
A
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G
T
T
C
A
G
G
G
T
G
A
A
G
A
A
G
G
A
G
C
T
0.056751
0.027397
0.046967
0.02544
0.041096
0.021526
0.007828
0.027397
0.060665
0.035225
0.04501
0.027397
0.037182
0.037182
0.037182
0.02544
0.043053
0.033268
0.037182
0.005871
0.003914
0.001957
0.039139
0.039139
0.039139
0.02544
0.019569
0.033268
0.029354
0.019569
0.023483
0.046967
1
12,196
G
A
C
C
T
A
T
C
T
T
T
T
T
C
T
T
T
T
G
T
T
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C
A
A
T
G
A
A
C
A
G
G
T
T
C
A
G
G
G
T
G
A
0.056751
0.027397
0.048924
0.027397
0.039139
0.021526
0.007828
0.02544
0.058708
0.035225
0.046967
0.027397
0.037182
0.037182
0.039139
0.023483
0.041096
0.033268
0.037182
0.005871
0.003914
0.001957
0.037182
0.039139
0.039139
0.02544
0.019569
0.037182
0.029354
0.017613
0.023483
0.048924
1
12,197
G
G
A
G
A
C
C
T
A
T
C
T
T
T
T
T
C
T
T
T
T
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C
A
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C
A
A
T
G
A
A
C
A
G
G
T
T
C
A
G
G
G
0.056751
0.027397
0.046967
0.027397
0.039139
0.021526
0.007828
0.02544
0.058708
0.035225
0.046967
0.029354
0.037182
0.037182
0.039139
0.023483
0.041096
0.033268
0.037182
0.005871
0.003914
0.001957
0.039139
0.039139
0.039139
0.02544
0.019569
0.037182
0.027397
0.017613
0.023483
0.048924
1
12,198
G
G
A
G
A
C
C
T
A
T
C
T
T
T
T
T
C
T
T
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A
C
C
A
A
T
G
A
A
C
A
G
G
T
T
C
A
G
G
C
0.056751
0.027397
0.046967
0.027397
0.039139
0.021526
0.007828
0.02544
0.058708
0.035225
0.046967
0.029354
0.037182
0.037182
0.039139
0.023483
0.041096
0.033268
0.037182
0.005871
0.003914
0.001957
0.039139
0.039139
0.039139
0.02544
0.019569
0.037182
0.027397
0.017613
0.023483
0.048924
1
12,199
C
T
G
A
A
C
C
T
G
T
T
C
A
T
T
G
G
T
G
T
C
A
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A
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G
A
A
A
A
A
G
A
T
A
G
G
T
C
T
C
C
T
A
0.056751
0.027397
0.046967
0.029354
0.039139
0.021526
0.007828
0.02544
0.058708
0.035225
0.046967
0.029354
0.037182
0.037182
0.039139
0.023483
0.041096
0.033268
0.037182
0.005871
0.003914
0.001957
0.039139
0.037182
0.039139
0.02544
0.019569
0.037182
0.027397
0.017613
0.023483
0.048924
1
12,200
G
T
A
G
T
A
C
T
T
C
T
T
C
T
G
T
T
C
T
T
C
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G
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A
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C
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G
A
C
C
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G
A
A
G
T
A
A
A
G
G
A
G
G
G
A
A
G
A
A
G
C
0.054795
0.023483
0.060665
0.027397
0.029354
0.033268
0
0.031311
0.054795
0.035225
0.056751
0.023483
0.029354
0.027397
0.033268
0.017613
0.043053
0.035225
0.035225
0.007828
0.005871
0.005871
0.039139
0.035225
0.054795
0.021526
0.023483
0.021526
0.04501
0.031311
0.023483
0.033268
1
12,201
C
T
T
C
C
C
T
C
C
T
T
T
A
C
T
T
C
G
G
A
G
G
T
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A
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A
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A
A
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A
A
G
T
A
C
T
A
C
A
A
T
A
0.054795
0.023483
0.060665
0.029354
0.029354
0.033268
0
0.031311
0.054795
0.035225
0.056751
0.021526
0.027397
0.027397
0.033268
0.017613
0.043053
0.035225
0.035225
0.007828
0.005871
0.005871
0.037182
0.035225
0.054795
0.021526
0.023483
0.021526
0.04501
0.031311
0.027397
0.033268
1
12,202
T
T
T
C
A
T
G
G
C
A
T
T
G
T
A
G
T
A
C
T
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C
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T
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G
T
C
C
T
G
A
C
C
T
C
C
G
A
A
G
T
A
A
A
T
0.052838
0.023483
0.062622
0.027397
0.029354
0.033268
0
0.029354
0.054795
0.035225
0.058708
0.021526
0.027397
0.029354
0.033268
0.017613
0.043053
0.035225
0.039139
0.007828
0.005871
0.005871
0.037182
0.035225
0.052838
0.019569
0.02544
0.023483
0.041096
0.031311
0.027397
0.033268
1
12,203
A
G
G
A
A
T
C
G
T
C
T
T
T
G
A
T
T
T
T
G
T
C
A
C
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C
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C
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G
A
C
A
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G
T
T
A
T
C
A
T
G
A
T
G
C
T
C
A
T
C
T
G
C
C
A
0.046967
0.031311
0.048924
0.027397
0.041096
0.037182
0.005871
0.02544
0.046967
0.039139
0.043053
0.015656
0.037182
0.04501
0.04501
0.035225
0.039139
0.050881
0.023483
0
0.013699
0.003914
0.015656
0.050881
0.041096
0.021526
0.023483
0.011742
0.043053
0.021526
0.021526
0.046967
1
12,204
G
A
A
C
A
T
C
T
T
C
G
A
C
T
T
C
G
T
G
G
T
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G
T
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G
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A
G
T
G
G
G
G
T
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G
G
G
G
A
A
G
T
A
G
G
C
G
0.039139
0.02544
0.039139
0.029354
0.04501
0.029354
0.005871
0.039139
0.041096
0.021526
0.04501
0.011742
0.037182
0.048924
0.037182
0.046967
0.041096
0.041096
0.033268
0.003914
0.013699
0.003914
0.019569
0.046967
0.039139
0.031311
0.027397
0.021526
0.039139
0.015656
0.019569
0.060665
1
12,205
A
G
A
T
G
C
G
C
C
C
A
A
T
A
C
G
G
G
C
C
A
A
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C
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G
G
G
A
A
A
C
A
A
A
G
T
A
T
T
T
C
T
C
A
T
0.060665
0.029354
0.048924
0.043053
0.037182
0.015656
0.009785
0.019569
0.043053
0.015656
0.046967
0.029354
0.035225
0.048924
0.050881
0.015656
0.037182
0.037182
0.037182
0.007828
0.013699
0.011742
0.009785
0.029354
0.046967
0.021526
0.037182
0.04501
0.033268
0.015656
0.023483
0.043053
1
12,206
T
C
A
G
A
C
G
C
A
A
G
A
T
G
C
G
C
C
C
A
A
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C
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T
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G
A
A
T
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G
G
G
T
T
G
G
G
G
A
A
A
C
A
A
A
G
A
0.058708
0.031311
0.048924
0.043053
0.037182
0.017613
0.009785
0.019569
0.043053
0.019569
0.046967
0.029354
0.035225
0.048924
0.050881
0.015656
0.039139
0.035225
0.035225
0.007828
0.013699
0.011742
0.009785
0.029354
0.046967
0.021526
0.037182
0.041096
0.031311
0.015656
0.023483
0.04501
1
12,207
T
G
T
T
T
C
C
C
C
A
A
C
C
C
T
A
T
T
C
C
G
A
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T
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C
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C
C
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G
T
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T
T
G
G
G
C
G
C
A
T
C
T
T
G
C
G
T
C
T
G
A
T
C
A
G
0.058708
0.031311
0.046967
0.043053
0.037182
0.019569
0.009785
0.017613
0.043053
0.019569
0.046967
0.029354
0.035225
0.048924
0.050881
0.015656
0.041096
0.037182
0.035225
0.007828
0.013699
0.011742
0.009785
0.029354
0.046967
0.019569
0.037182
0.041096
0.031311
0.015656
0.023483
0.04501
1
12,208
T
T
C
C
C
C
A
A
C
C
C
T
A
T
T
C
C
G
A
G
T
C
A
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C
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G
A
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G
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C
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T
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G
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C
A
T
C
T
T
G
C
G
T
C
T
G
A
T
C
A
A
A
G
A
0.058708
0.033268
0.046967
0.043053
0.037182
0.019569
0.009785
0.017613
0.043053
0.019569
0.04501
0.029354
0.035225
0.048924
0.052838
0.015656
0.039139
0.039139
0.035225
0.007828
0.013699
0.011742
0.009785
0.029354
0.046967
0.019569
0.037182
0.041096
0.029354
0.015656
0.023483
0.04501
1
12,209
C
A
A
A
G
G
G
A
T
T
C
G
T
A
C
C
C
T
G
C
T
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T
T
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C
C
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A
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C
C
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C
C
T
G
C
C
C
T
G
T
T
C
A
A
C
A
T
C
G
G
C
C
G
0.050881
0.035225
0.04501
0.037182
0.035225
0.023483
0.007828
0.013699
0.041096
0.021526
0.054795
0.029354
0.039139
0.046967
0.048924
0.013699
0.04501
0.037182
0.041096
0.009785
0.013699
0.011742
0.013699
0.02544
0.04501
0.017613
0.04501
0.043053
0.035225
0.011742
0.023483
0.037182
1
12,210
C
A
G
G
A
A
G
A
G
C
A
G
A
A
G
G
C
C
G
A
T
G
T
T
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A
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C
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C
A
T
T
A
A
G
G
C
A
A
A
G
A
G
C
A
G
G
G
T
0.052838
0.035225
0.046967
0.035225
0.035225
0.023483
0.007828
0.011742
0.041096
0.023483
0.054795
0.027397
0.039139
0.046967
0.048924
0.013699
0.043053
0.039139
0.043053
0.009785
0.013699
0.011742
0.013699
0.027397
0.043053
0.017613
0.039139
0.043053
0.037182
0.011742
0.02544
0.037182
1
12,211
C
C
T
G
C
T
C
T
T
T
G
C
C
T
T
A
A
T
G
A
T
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C
G
G
C
C
T
T
C
T
G
C
T
C
T
T
C
C
T
G
G
T
0.052838
0.035225
0.046967
0.035225
0.035225
0.023483
0.007828
0.011742
0.041096
0.023483
0.054795
0.027397
0.041096
0.046967
0.046967
0.013699
0.043053
0.039139
0.043053
0.009785
0.013699
0.011742
0.013699
0.027397
0.043053
0.017613
0.039139
0.043053
0.037182
0.011742
0.02544
0.037182
1
12,212
T
G
G
C
C
T
G
C
T
G
C
T
G
C
C
C
A
T
C
C
T
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A
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C
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C
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C
C
T
A
G
A
T
A
A
G
G
A
A
C
A
C
C
C
A
G
G
G
A
G
0.033268
0.031311
0.043053
0.023483
0.043053
0.023483
0.005871
0.021526
0.04501
0.027397
0.048924
0.009785
0.046967
0.060665
0.039139
0.02544
0.050881
0.041096
0.043053
0.005871
0.017613
0.001957
0.013699
0.037182
0.043053
0.021526
0.041096
0.037182
0.035225
0.015656
0.015656
0.050881
1
12,213
G
G
C
T
A
C
A
C
T
G
A
A
G
T
T
C
T
C
C
A
G
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A
C
A
A
T
T
A
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G
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A
A
G
A
G
A
T
G
A
G
0.021526
0.02544
0.039139
0.019569
0.035225
0.023483
0.003914
0.031311
0.043053
0.041096
0.037182
0.009785
0.052838
0.056751
0.039139
0.029354
0.052838
0.050881
0.043053
0.007828
0.019569
0.007828
0.015656
0.04501
0.031311
0.019569
0.04501
0.035225
0.037182
0.019569
0.013699
0.046967
1
12,214
G
T
C
T
G
C
A
C
T
T
T
C
C
T
C
T
G
T
G
G
C
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G
G
C
A
A
T
G
T
A
C
A
T
G
T
T
C
A
C
G
A
C
0.027397
0.02544
0.041096
0.019569
0.035225
0.023483
0.001957
0.031311
0.043053
0.037182
0.039139
0.007828
0.052838
0.056751
0.043053
0.029354
0.050881
0.050881
0.043053
0.007828
0.015656
0.007828
0.015656
0.043053
0.031311
0.019569
0.04501
0.035225
0.039139
0.017613
0.013699
0.048924
1
12,215
A
G
A
T
C
T
G
G
G
A
G
A
A
G
T
T
C
G
A
C
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A
C
T
G
T
A
A
G
C
T
G
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C
A
G
A
C
T
T
T
G
0.021526
0.017613
0.048924
0.019569
0.027397
0.023483
0.005871
0.033268
0.046967
0.037182
0.037182
0.009785
0.050881
0.046967
0.037182
0.031311
0.043053
0.054795
0.046967
0.015656
0.017613
0.015656
0.015656
0.046967
0.033268
0.021526
0.041096
0.031311
0.052838
0.019569
0.013699
0.035225
1
12,216
G
G
T
C
C
T
G
G
G
A
G
A
T
A
G
C
G
G
G
G
A
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G
G
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A
G
A
G
C
G
G
T
T
C
G
T
G
G
C
A
T
C
0.027397
0.011742
0.043053
0.017613
0.02544
0.027397
0.009785
0.029354
0.043053
0.041096
0.037182
0.013699
0.043053
0.039139
0.041096
0.035225
0.04501
0.052838
0.041096
0.02544
0.017613
0.021526
0.013699
0.050881
0.023483
0.027397
0.054795
0.031311
0.056751
0.017613
0.007828
0.027397
1
12,217
A
G
T
T
G
G
A
C
A
T
C
C
T
G
C
G
G
C
A
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G
T
G
T
C
T
G
0.031311
0.015656
0.043053
0.017613
0.02544
0.029354
0.009785
0.027397
0.043053
0.041096
0.039139
0.013699
0.041096
0.037182
0.039139
0.033268
0.04501
0.052838
0.041096
0.02544
0.017613
0.021526
0.015656
0.046967
0.027397
0.02544
0.054795
0.031311
0.056751
0.017613
0.011742
0.021526
1
12,218
A
G
T
T
G
G
A
C
A
T
C
C
T
G
C
G
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C
A
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A
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G
T
G
T
C
T
T
0.031311
0.015656
0.043053
0.017613
0.02544
0.029354
0.009785
0.027397
0.043053
0.041096
0.039139
0.013699
0.041096
0.037182
0.039139
0.033268
0.04501
0.052838
0.041096
0.02544
0.017613
0.021526
0.015656
0.046967
0.027397
0.02544
0.054795
0.031311
0.056751
0.017613
0.011742
0.021526
1
12,219
A
A
G
A
C
A
C
T
T
T
G
G
A
A
G
G
A
T
T
G
G
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G
C
T
G
C
C
G
C
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G
G
A
T
G
T
C
C
A
A
C
T
0.033268
0.015656
0.043053
0.017613
0.02544
0.029354
0.009785
0.027397
0.043053
0.041096
0.039139
0.013699
0.041096
0.037182
0.039139
0.033268
0.04501
0.052838
0.041096
0.02544
0.017613
0.021526
0.015656
0.046967
0.027397
0.023483
0.054795
0.031311
0.056751
0.017613
0.011742
0.021526
1
12,220
A
A
G
A
C
A
C
T
T
T
G
G
A
A
G
G
A
T
T
G
G
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G
C
T
G
C
C
G
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A
G
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A
T
G
T
C
C
A
A
C
A
0.033268
0.015656
0.043053
0.017613
0.02544
0.029354
0.009785
0.027397
0.043053
0.041096
0.039139
0.013699
0.041096
0.037182
0.039139
0.033268
0.04501
0.052838
0.041096
0.02544
0.017613
0.021526
0.015656
0.046967
0.027397
0.023483
0.054795
0.031311
0.056751
0.017613
0.011742
0.021526
1
12,221
C
T
G
T
G
A
A
G
C
C
G
T
C
T
C
G
G
G
G
C
C
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G
C
C
C
A
C
A
T
T
G
C
A
A
G
G
G
G
C
C
T
C
0.015656
0.015656
0.029354
0.003914
0.037182
0.039139
0.017613
0.023483
0.033268
0.054795
0.062622
0
0.007828
0.011742
0.021526
0.050881
0.074364
0.043053
0.091977
0.023483
0.013699
0.011742
0.011742
0.056751
0.02544
0.037182
0.046967
0.043053
0.048924
0.013699
0.001957
0.031311
1
12,222
C
G
C
T
G
G
T
G
A
C
C
T
G
C
A
C
G
T
G
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C
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C
C
T
G
C
C
G
G
G
G
G
G
C
C
T
G
G
T
G
C
G
0.011742
0.015656
0.031311
0.003914
0.035225
0.039139
0.017613
0.023483
0.033268
0.050881
0.066536
0
0.007828
0.011742
0.019569
0.050881
0.074364
0.041096
0.097847
0.023483
0.013699
0.011742
0.011742
0.056751
0.027397
0.035225
0.048924
0.043053
0.048924
0.013699
0.001957
0.031311
1
12,223
C
T
C
C
C
G
C
A
C
C
A
G
C
A
C
T
A
C
T
G
T
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C
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G
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G
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C
C
C
C
T
T
G
C
A
A
T
G
T
G
G
G
C
T
C
T
T
0.009785
0.015656
0.029354
0.005871
0.033268
0.039139
0.017613
0.021526
0.035225
0.046967
0.066536
0
0.007828
0.015656
0.021526
0.048924
0.07045
0.04501
0.097847
0.023483
0.013699
0.011742
0.011742
0.060665
0.027397
0.033268
0.048924
0.04501
0.050881
0.013699
0.001957
0.029354
1
12,224
C
T
C
C
C
C
T
C
C
T
C
C
C
G
C
A
C
C
A
G
C
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C
A
G
G
T
A
G
G
C
C
C
C
T
T
G
C
A
A
T
G
G
0.011742
0.015656
0.031311
0.005871
0.033268
0.039139
0.017613
0.021526
0.033268
0.04501
0.068493
0.001957
0.007828
0.015656
0.021526
0.048924
0.066536
0.04501
0.101761
0.023483
0.013699
0.011742
0.011742
0.056751
0.027397
0.033268
0.046967
0.046967
0.050881
0.013699
0.003914
0.027397
1
12,225
C
T
C
C
C
C
T
C
C
T
C
C
C
G
C
A
C
C
A
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C
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C
A
G
G
T
A
G
G
C
C
C
C
T
T
G
C
A
A
T
G
A
0.011742
0.015656
0.031311
0.005871
0.033268
0.039139
0.017613
0.021526
0.033268
0.04501
0.068493
0.001957
0.007828
0.015656
0.021526
0.048924
0.066536
0.04501
0.101761
0.023483
0.013699
0.011742
0.011742
0.056751
0.027397
0.033268
0.046967
0.046967
0.050881
0.013699
0.003914
0.027397
1
12,226
G
C
C
T
C
C
C
C
T
C
C
T
C
C
C
G
C
A
C
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A
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C
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G
G
C
A
G
G
T
A
G
G
C
C
C
C
T
T
G
C
A
A
T
0.011742
0.015656
0.031311
0.005871
0.033268
0.039139
0.017613
0.021526
0.033268
0.046967
0.066536
0.001957
0.007828
0.015656
0.021526
0.048924
0.068493
0.04501
0.099804
0.023483
0.013699
0.011742
0.011742
0.056751
0.027397
0.033268
0.046967
0.046967
0.050881
0.013699
0.003914
0.027397
1
12,227
A
G
G
A
G
G
G
G
A
G
G
C
A
C
C
C
C
C
A
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C
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C
A
C
A
G
G
G
A
G
C
T
C
T
G
C
A
G
G
G
G
G
C
0.007828
0.015656
0.021526
0.005871
0.033268
0.039139
0.017613
0.023483
0.035225
0.04501
0.060665
0.001957
0.007828
0.011742
0.019569
0.052838
0.072407
0.052838
0.111546
0.027397
0.013699
0.015656
0.013699
0.054795
0.019569
0.033268
0.050881
0.052838
0.048924
0.011742
0.003914
0.017613
1
12,228
G
C
C
C
C
C
T
G
C
A
G
A
G
C
T
C
C
C
T
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T
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A
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C
C
T
G
G
G
G
G
T
G
C
C
T
C
C
C
C
T
C
C
T
0.007828
0.015656
0.021526
0.005871
0.033268
0.039139
0.017613
0.023483
0.035225
0.04501
0.060665
0.001957
0.007828
0.011742
0.017613
0.052838
0.074364
0.052838
0.111546
0.027397
0.013699
0.015656
0.013699
0.054795
0.019569
0.033268
0.050881
0.052838
0.048924
0.011742
0.003914
0.017613
1
12,229
C
G
G
G
G
C
T
G
C
G
G
G
A
A
C
T
T
G
C
A
C
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C
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A
C
C
G
A
G
T
T
C
G
T
C
A
A
C
C
A
C
T
A
G
0.005871
0.013699
0.019569
0.005871
0.029354
0.039139
0.015656
0.023483
0.031311
0.048924
0.060665
0.001957
0.007828
0.011742
0.015656
0.052838
0.072407
0.056751
0.117417
0.029354
0.013699
0.015656
0.015656
0.056751
0.019569
0.029354
0.050881
0.056751
0.050881
0.011742
0.003914
0.015656
1
12,230
C
T
C
A
G
G
G
C
T
C
C
C
C
T
T
C
C
T
G
G
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A
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T
G
C
C
T
T
G
G
T
G
G
A
G
T
G
T
G
T
G
G
A
0.009785
0.013699
0.013699
0.013699
0.021526
0.052838
0.007828
0.027397
0.037182
0.041096
0.072407
0.003914
0.011742
0.005871
0.015656
0.060665
0.086106
0.072407
0.080235
0.019569
0.007828
0.003914
0.013699
0.064579
0.023483
0.02544
0.043053
0.060665
0.050881
0.007828
0.001957
0.029354
1
12,231
G
G
C
T
C
C
C
C
T
T
C
C
T
G
G
T
G
C
A
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A
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C
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T
G
G
T
G
G
A
G
T
G
T
G
T
G
G
G
T
G
A
G
G
0.009785
0.013699
0.013699
0.013699
0.021526
0.052838
0.007828
0.027397
0.039139
0.041096
0.07045
0.003914
0.011742
0.005871
0.015656
0.060665
0.084149
0.072407
0.080235
0.019569
0.007828
0.003914
0.013699
0.064579
0.023483
0.027397
0.043053
0.060665
0.050881
0.007828
0.001957
0.029354
1
12,232
A
C
T
G
C
T
C
A
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C
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T
C
C
T
C
T
G
C
A
C
C
A
G
G
A
A
G
G
G
G
C
0.009785
0.013699
0.013699
0.013699
0.019569
0.052838
0.007828
0.027397
0.039139
0.041096
0.07045
0.003914
0.013699
0.005871
0.015656
0.058708
0.086106
0.074364
0.080235
0.019569
0.007828
0.003914
0.013699
0.064579
0.023483
0.02544
0.043053
0.060665
0.050881
0.007828
0.001957
0.029354
1
12,233
C
T
T
G
A
C
G
G
C
C
A
C
A
C
T
C
T
C
A
C
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G
C
C
A
T
A
G
C
G
G
C
C
T
T
T
T
C
C
T
G
G
0.02544
0.031311
0.033268
0.007828
0.035225
0.037182
0.009785
0.021526
0.050881
0.031311
0.060665
0.005871
0.021526
0.015656
0.021526
0.046967
0.07045
0.054795
0.080235
0.017613
0.011742
0.011742
0.013699
0.048924
0.027397
0.023483
0.039139
0.062622
0.033268
0.001957
0.021526
0.02544
1
12,234
C
C
A
G
G
A
C
T
G
T
T
C
A
T
C
C
C
T
C
G
A
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C
T
C
A
C
C
G
T
G
C
C
A
C
A
A
G
C
C
C
C
C
0.035225
0.029354
0.029354
0.031311
0.035225
0.035225
0.007828
0.021526
0.04501
0.029354
0.056751
0.005871
0.021526
0.015656
0.021526
0.046967
0.066536
0.050881
0.076321
0.015656
0.011742
0.011742
0.009785
0.046967
0.021526
0.021526
0.039139
0.056751
0.031311
0.001957
0.04501
0.02544
1
12,235
C
G
G
T
G
A
G
A
G
T
G
T
G
G
C
C
G
T
C
A
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T
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C
T
G
G
T
T
C
C
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G
G
A
G
A
C
T
G
G
0.043053
0.029354
0.029354
0.039139
0.035225
0.033268
0.007828
0.021526
0.043053
0.029354
0.054795
0.005871
0.021526
0.015656
0.023483
0.046967
0.062622
0.050881
0.072407
0.011742
0.011742
0.011742
0.009785
0.046967
0.021526
0.019569
0.035225
0.056751
0.029354
0.001957
0.052838
0.02544
1
12,236
C
A
G
C
T
G
C
G
T
G
C
T
C
G
A
G
T
T
G
C
G
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C
C
T
G
T
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A
A
A
G
G
T
T
G
T
0.007828
0.017613
0.031311
0.007828
0.029354
0.041096
0.017613
0.023483
0.041096
0.058708
0.04501
0
0.015656
0.023483
0.035225
0.048924
0.066536
0.058708
0.060665
0.017613
0.019569
0.027397
0.019569
0.050881
0.011742
0.037182
0.054795
0.054795
0.02544
0.009785
0.009785
0.031311
1
12,237
A
C
A
G
C
T
G
C
G
T
G
C
T
C
G
A
G
T
T
G
C
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G
C
C
T
G
T
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T
G
C
A
G
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A
A
G
G
T
T
C
0.007828
0.017613
0.031311
0.007828
0.029354
0.041096
0.017613
0.023483
0.041096
0.058708
0.04501
0
0.015656
0.023483
0.035225
0.046967
0.066536
0.058708
0.060665
0.017613
0.019569
0.027397
0.019569
0.050881
0.011742
0.039139
0.054795
0.054795
0.02544
0.009785
0.009785
0.031311
1
12,238
A
G
A
C
A
T
G
A
C
C
T
C
C
C
G
C
A
A
C
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C
A
C
T
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C
C
A
C
G
A
G
C
A
C
G
G
C
T
C
0.005871
0.015656
0.02544
0.007828
0.027397
0.04501
0.017613
0.021526
0.039139
0.058708
0.04501
0
0.015656
0.023483
0.027397
0.046967
0.07045
0.054795
0.068493
0.023483
0.019569
0.037182
0.019569
0.048924
0.011742
0.039139
0.052838
0.056751
0.021526
0.009785
0.009785
0.033268
1
12,239
C
T
A
C
C
A
C
G
A
G
C
A
C
G
G
C
T
C
C
C
T
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G
C
T
G
G
A
G
C
C
C
C
A
T
C
T
G
G
C
T
C
C
0.007828
0.013699
0.027397
0.005871
0.031311
0.041096
0.017613
0.017613
0.039139
0.060665
0.048924
0
0.013699
0.023483
0.027397
0.050881
0.066536
0.048924
0.068493
0.02544
0.019569
0.043053
0.017613
0.054795
0.013699
0.035225
0.052838
0.054795
0.02544
0.007828
0.005871
0.033268
1
12,240
C
T
C
C
C
T
C
T
A
C
G
A
C
T
T
T
C
T
G
C
A
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G
G
C
T
C
T
G
A
G
G
C
T
A
G
C
T
G
T
G
T
G
0.007828
0.013699
0.027397
0.005871
0.029354
0.04501
0.017613
0.017613
0.033268
0.056751
0.048924
0
0.015656
0.027397
0.027397
0.052838
0.060665
0.050881
0.07045
0.027397
0.019569
0.04501
0.017613
0.050881
0.013699
0.033268
0.052838
0.056751
0.02544
0.007828
0.005871
0.035225
1
12,241
T
G
G
A
G
C
C
C
C
A
T
C
T
G
G
C
T
C
T
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C
C
T
G
G
C
G
C
A
C
C
T
G
C
A
C
G
T
G
C
0.013699
0.015656
0.027397
0.011742
0.031311
0.039139
0.017613
0.019569
0.033268
0.056751
0.046967
0
0.013699
0.029354
0.029354
0.052838
0.058708
0.04501
0.058708
0.027397
0.019569
0.04501
0.017613
0.052838
0.015656
0.031311
0.058708
0.054795
0.02544
0.007828
0.007828
0.035225
1
12,242
A
C
C
G
A
A
G
A
T
C
T
C
C
A
C
G
T
G
C
A
G
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G
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C
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A
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C
C
G
C
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G
A
C
A
C
A
G
C
T
A
G
C
C
T
C
A
G
A
G
C
C
A
T
0.015656
0.017613
0.02544
0.011742
0.031311
0.039139
0.017613
0.019569
0.035225
0.050881
0.048924
0
0.013699
0.029354
0.029354
0.050881
0.058708
0.04501
0.058708
0.027397
0.019569
0.04501
0.013699
0.056751
0.019569
0.031311
0.056751
0.054795
0.027397
0.007828
0.005871
0.035225
1
12,243
T
A
C
C
G
A
A
G
A
T
C
T
C
C
A
C
G
T
G
C
A
G
G
T
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C
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C
C
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G
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C
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C
A
T
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C
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A
C
A
C
A
G
C
T
A
G
C
C
T
C
A
G
A
G
C
C
T
0.015656
0.017613
0.02544
0.011742
0.031311
0.039139
0.017613
0.019569
0.035225
0.050881
0.048924
0
0.013699
0.029354
0.029354
0.050881
0.058708
0.04501
0.058708
0.027397
0.019569
0.04501
0.013699
0.056751
0.019569
0.029354
0.056751
0.054795
0.029354
0.007828
0.005871
0.035225
1
12,244
C
T
A
G
C
T
G
T
G
T
C
C
G
C
G
G
C
A
T
G
C
G
G
C
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G
G
C
G
C
A
C
C
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C
A
C
G
T
G
G
A
G
A
T
C
T
T
C
G
G
T
A
C
A
C
A
G
G
G
C
A
A
G
0.015656
0.017613
0.027397
0.009785
0.031311
0.039139
0.017613
0.017613
0.037182
0.050881
0.048924
0
0.013699
0.027397
0.031311
0.050881
0.056751
0.041096
0.060665
0.029354
0.019569
0.046967
0.013699
0.056751
0.019569
0.029354
0.058708
0.054795
0.027397
0.007828
0.005871
0.035225
1
12,245
A
G
C
T
G
T
G
T
C
C
G
C
G
G
C
A
T
G
C
G
G
C
C
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G
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C
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C
C
T
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C
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C
G
T
G
G
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G
A
T
C
T
T
C
G
G
T
A
C
A
C
A
G
G
G
C
A
A
A
C
G
0.015656
0.017613
0.027397
0.009785
0.031311
0.039139
0.017613
0.017613
0.037182
0.050881
0.048924
0
0.013699
0.027397
0.031311
0.052838
0.056751
0.043053
0.060665
0.029354
0.019569
0.046967
0.013699
0.056751
0.017613
0.029354
0.058708
0.054795
0.02544
0.007828
0.005871
0.035225
1
12,246
C
T
G
T
G
T
C
C
G
C
G
G
C
A
T
G
C
G
G
C
C
T
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G
C
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C
A
C
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T
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C
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T
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G
A
G
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T
C
G
G
T
A
C
A
C
A
G
G
G
C
A
A
A
C
C
A
T
0.015656
0.017613
0.027397
0.009785
0.031311
0.039139
0.019569
0.017613
0.037182
0.050881
0.046967
0
0.013699
0.027397
0.031311
0.052838
0.056751
0.043053
0.058708
0.029354
0.021526
0.046967
0.013699
0.056751
0.017613
0.029354
0.058708
0.054795
0.02544
0.007828
0.005871
0.035225
1
12,247
G
C
G
G
T
G
G
G
C
A
A
T
G
G
C
T
G
G
T
T
T
G
C
C
C
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G
T
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C
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A
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C
T
C
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C
G
T
G
C
A
G
G
T
G
C
G
C
C
A
G
G
C
C
G
C
G
0.015656
0.019569
0.027397
0.009785
0.035225
0.039139
0.019569
0.019569
0.037182
0.050881
0.046967
0
0.013699
0.027397
0.031311
0.052838
0.058708
0.039139
0.050881
0.029354
0.021526
0.046967
0.013699
0.054795
0.019569
0.031311
0.058708
0.054795
0.023483
0.007828
0.005871
0.037182
1
12,248
T
G
A
C
C
A
G
C
A
C
A
T
T
G
C
G
G
C
T
C
T
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G
A
A
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C
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G
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G
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C
A
A
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G
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C
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G
T
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T
G
C
C
C
T
G
T
G
T
A
C
C
G
A
A
G
G
0.021526
0.021526
0.029354
0.011742
0.035225
0.039139
0.017613
0.017613
0.039139
0.048924
0.043053
0.001957
0.015656
0.029354
0.033268
0.054795
0.054795
0.043053
0.046967
0.029354
0.019569
0.046967
0.013699
0.050881
0.02544
0.02544
0.058708
0.052838
0.023483
0.007828
0.005871
0.035225
1
12,249
G
C
T
C
T
T
G
A
C
C
A
G
C
A
C
A
T
T
G
C
G
G
C
T
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A
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C
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G
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G
G
G
C
A
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T
G
G
C
T
G
G
T
T
T
G
C
C
C
T
G
T
G
T
A
C
A
0.021526
0.021526
0.029354
0.011742
0.035225
0.041096
0.017613
0.017613
0.039139
0.046967
0.043053
0.001957
0.017613
0.031311
0.033268
0.054795
0.054795
0.04501
0.04501
0.029354
0.019569
0.046967
0.011742
0.050881
0.02544
0.02544
0.058708
0.050881
0.023483
0.009785
0.003914
0.035225
1
12,250
A
C
A
C
A
G
G
G
C
A
A
A
C
C
A
G
C
C
A
T
T
G
C
C
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A
T
G
T
G
C
T
G
G
T
C
A
A
G
A
G
C
A
A
G
0.021526
0.021526
0.029354
0.011742
0.035225
0.041096
0.017613
0.017613
0.039139
0.046967
0.04501
0.001957
0.017613
0.031311
0.033268
0.054795
0.054795
0.043053
0.043053
0.029354
0.019569
0.046967
0.011742
0.050881
0.02544
0.02544
0.058708
0.050881
0.02544
0.009785
0.003914
0.035225
1
12,251
A
C
A
G
G
G
C
A
A
A
C
C
A
G
C
C
A
T
T
G
C
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G
T
G
C
T
G
G
T
C
A
A
G
A
G
C
A
A
C
C
C
0.021526
0.021526
0.029354
0.011742
0.035225
0.041096
0.017613
0.017613
0.039139
0.04501
0.04501
0.001957
0.017613
0.031311
0.033268
0.054795
0.054795
0.04501
0.043053
0.029354
0.019569
0.046967
0.011742
0.050881
0.02544
0.02544
0.058708
0.050881
0.02544
0.009785
0.003914
0.035225
1
12,252
A
C
T
G
C
A
G
G
T
T
G
C
T
C
T
T
G
A
C
C
A
G
C
A
C
A
T
T
G
C
G
G
C
T
C
T
T
G
A
A
G
T
C
G
C
G
G
T
G
G
G
C
A
A
T
G
G
C
T
G
G
T
T
T
G
A
0.021526
0.021526
0.027397
0.011742
0.035225
0.041096
0.017613
0.017613
0.039139
0.046967
0.043053
0.001957
0.017613
0.031311
0.031311
0.054795
0.056751
0.046967
0.039139
0.029354
0.019569
0.046967
0.011742
0.052838
0.02544
0.02544
0.058708
0.050881
0.027397
0.009785
0.003914
0.035225
1
12,253
C
C
C
C
G
C
C
C
G
G
C
T
C
A
C
C
C
A
G
G
T
C
G
G
C
G
A
T
G
C
A
A
C
A
C
T
G
C
A
G
G
T
T
G
C
T
C
T
T
G
A
C
C
A
G
C
A
C
A
T
T
G
C
G
G
T
0.021526
0.023483
0.02544
0.011742
0.031311
0.039139
0.017613
0.017613
0.039139
0.04501
0.048924
0.001957
0.017613
0.031311
0.031311
0.048924
0.054795
0.046967
0.039139
0.029354
0.019569
0.046967
0.011742
0.058708
0.027397
0.023483
0.056751
0.050881
0.037182
0.009785
0.003914
0.031311
1
12,254
C
C
C
C
G
C
C
C
G
G
C
T
C
A
C
C
C
A
G
G
T
C
G
G
C
G
A
T
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A
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C
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G
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G
C
T
C
T
T
G
A
C
C
A
G
C
A
C
A
T
T
G
C
G
G
A
0.021526
0.023483
0.02544
0.011742
0.031311
0.039139
0.017613
0.017613
0.039139
0.04501
0.048924
0.001957
0.017613
0.031311
0.031311
0.048924
0.054795
0.046967
0.039139
0.029354
0.019569
0.046967
0.011742
0.058708
0.027397
0.023483
0.056751
0.050881
0.037182
0.009785
0.003914
0.031311
1
12,255
G
C
G
C
G
C
C
C
C
T
G
C
C
C
C
G
C
C
C
G
G
C
T
C
A
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G
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C
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T
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C
A
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C
T
G
C
A
G
G
T
T
G
C
T
C
T
T
G
A
C
C
A
A
0.021526
0.02544
0.02544
0.011742
0.031311
0.041096
0.017613
0.017613
0.041096
0.04501
0.048924
0.001957
0.015656
0.031311
0.031311
0.048924
0.054795
0.048924
0.041096
0.029354
0.017613
0.04501
0.011742
0.058708
0.027397
0.023483
0.056751
0.048924
0.037182
0.009785
0.003914
0.029354
1
12,256
T
G
A
A
G
G
G
C
G
C
G
C
C
C
C
T
G
C
C
C
C
G
C
C
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C
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C
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G
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C
G
G
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G
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T
G
C
A
A
C
A
C
T
G
C
A
G
G
T
T
G
C
T
C
T
G
0.021526
0.02544
0.02544
0.011742
0.029354
0.043053
0.017613
0.017613
0.039139
0.04501
0.050881
0.001957
0.017613
0.027397
0.031311
0.048924
0.056751
0.050881
0.041096
0.029354
0.017613
0.04501
0.011742
0.058708
0.027397
0.021526
0.056751
0.048924
0.039139
0.009785
0.003914
0.027397
1
12,257
T
C
T
G
C
T
C
G
T
C
C
A
G
C
A
C
C
T
C
G
G
G
T
G
C
C
A
T
G
T
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C
C
G
C
T
T
G
G
T
G
C
C
C
A
C
T
C
T
C
G
G
G
T
T
G
T
T
G
C
C
G
A
T
G
T
0.013699
0.011742
0.023483
0.007828
0.035225
0.037182
0.011742
0.02544
0.033268
0.027397
0.062622
0
0.02544
0.033268
0.023483
0.054795
0.072407
0.076321
0.076321
0.019569
0.011742
0.007828
0.005871
0.046967
0.017613
0.02544
0.050881
0.074364
0.048924
0.015656
0.001957
0.021526
1
12,258
G
G
A
T
C
T
G
C
T
C
G
T
C
C
A
G
C
A
C
C
T
C
G
G
G
T
G
C
C
A
T
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T
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C
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T
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G
G
T
G
C
C
C
A
C
T
C
T
C
G
G
G
T
T
G
T
T
G
C
C
G
C
0.013699
0.011742
0.023483
0.007828
0.031311
0.039139
0.011742
0.02544
0.033268
0.027397
0.062622
0
0.02544
0.033268
0.023483
0.054795
0.072407
0.078278
0.076321
0.019569
0.011742
0.007828
0.005871
0.046967
0.017613
0.02544
0.050881
0.074364
0.048924
0.015656
0.001957
0.021526
1
12,259
C
A
A
C
A
A
C
C
C
G
A
G
A
G
T
G
G
G
C
A
C
C
A
A
G
C
G
G
T
A
C
A
T
G
G
C
A
C
C
C
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A
G
G
T
G
C
T
G
G
A
C
G
A
G
C
A
G
A
T
C
C
G
C
A
G
0.013699
0.011742
0.021526
0.007828
0.031311
0.039139
0.011742
0.02544
0.033268
0.027397
0.062622
0
0.02544
0.033268
0.021526
0.054795
0.074364
0.080235
0.076321
0.019569
0.011742
0.007828
0.005871
0.046967
0.017613
0.02544
0.050881
0.074364
0.048924
0.015656
0.001957
0.021526
1
12,260
C
G
T
G
C
G
G
A
T
C
T
G
C
T
C
G
T
C
C
A
G
C
A
C
C
T
C
G
G
G
T
G
C
C
A
T
G
T
A
C
C
G
C
T
T
G
G
T
G
C
C
C
A
C
T
C
T
C
G
G
G
T
T
G
T
T
0.013699
0.011742
0.021526
0.007828
0.031311
0.039139
0.011742
0.02544
0.033268
0.029354
0.062622
0
0.02544
0.033268
0.019569
0.054795
0.076321
0.080235
0.076321
0.019569
0.011742
0.007828
0.005871
0.046967
0.017613
0.02544
0.048924
0.074364
0.048924
0.015656
0.001957
0.021526
1
12,261
G
G
A
C
T
G
C
T
T
T
G
A
G
T
C
C
T
A
C
A
A
G
T
G
G
A
C
T
G
A
C
A
T
C
T
G
G
G
C
C
T
T
T
G
G
C
C
T
G
G
T
G
C
T
G
T
G
G
G
A
G
A
T
T
G
A
0.023483
0.017613
0.023483
0.007828
0.035225
0.04501
0.005871
0.02544
0.027397
0.031311
0.066536
0.005871
0.02544
0.027397
0.019569
0.050881
0.080235
0.07045
0.072407
0.017613
0.011742
0.007828
0.005871
0.043053
0.015656
0.029354
0.043053
0.062622
0.04501
0.013699
0.013699
0.029354
1
12,262
G
G
G
C
A
A
T
C
T
C
C
C
A
C
A
G
C
A
C
C
A
G
G
C
C
A
A
A
G
G
C
C
C
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G
A
T
G
T
C
A
G
T
C
C
A
C
T
T
G
T
A
G
G
A
C
T
C
A
A
A
G
C
A
G
A
0.023483
0.017613
0.023483
0.007828
0.035225
0.04501
0.005871
0.02544
0.027397
0.033268
0.066536
0.005871
0.02544
0.027397
0.019569
0.050881
0.082192
0.068493
0.072407
0.017613
0.011742
0.007828
0.005871
0.041096
0.015656
0.029354
0.043053
0.064579
0.043053
0.013699
0.013699
0.029354
1
12,263
G
G
T
C
C
G
G
C
G
G
G
C
A
A
T
C
T
C
C
C
A
C
A
G
C
A
C
C
A
G
G
C
C
A
A
A
G
G
C
C
C
A
G
A
T
G
T
C
A
G
T
C
C
A
C
T
T
G
T
A
G
G
A
C
T
T
0.02544
0.017613
0.021526
0.009785
0.037182
0.04501
0.005871
0.02544
0.027397
0.033268
0.064579
0.005871
0.02544
0.02544
0.019569
0.052838
0.080235
0.068493
0.072407
0.017613
0.011742
0.007828
0.005871
0.041096
0.017613
0.029354
0.041096
0.062622
0.043053
0.013699
0.013699
0.031311
1
12,264
C
C
C
T
C
A
C
C
A
T
T
C
A
C
G
A
T
G
G
T
C
C
G
G
C
G
G
G
C
A
A
T
C
T
C
C
C
A
C
A
G
C
A
C
C
A
G
G
C
C
A
A
A
G
G
C
C
C
A
G
A
T
G
T
C
A
0.02544
0.017613
0.023483
0.011742
0.037182
0.046967
0.005871
0.023483
0.023483
0.033268
0.062622
0.009785
0.027397
0.029354
0.021526
0.050881
0.078278
0.068493
0.068493
0.017613
0.011742
0.007828
0.005871
0.037182
0.015656
0.027397
0.041096
0.062622
0.039139
0.017613
0.017613
0.033268
1
12,265
T
G
T
A
G
G
G
T
G
G
G
C
C
C
T
C
A
C
C
A
T
T
C
A
C
G
A
T
G
G
T
C
C
G
G
C
G
G
G
C
A
A
T
C
T
C
C
C
A
C
A
G
C
A
C
C
A
G
G
C
C
A
A
A
G
G
0.02544
0.017613
0.023483
0.015656
0.037182
0.046967
0.005871
0.023483
0.021526
0.033268
0.062622
0.013699
0.027397
0.029354
0.021526
0.050881
0.076321
0.068493
0.068493
0.017613
0.011742
0.007828
0.005871
0.033268
0.015656
0.027397
0.041096
0.062622
0.039139
0.017613
0.019569
0.031311
1
12,266
A
T
T
T
C
C
A
G
G
C
A
T
C
G
T
G
G
A
G
G
A
C
T
A
T
A
G
A
C
C
A
C
C
C
T
T
C
T
A
T
G
A
T
G
T
G
G
T
G
C
C
C
A
A
T
G
A
C
C
C
C
A
G
C
T
G
0.027397
0.017613
0.023483
0.02544
0.041096
0.041096
0.005871
0.02544
0.048924
0.023483
0.052838
0.023483
0.023483
0.048924
0.021526
0.048924
0.052838
0.068493
0.048924
0.007828
0.001957
0.003914
0.031311
0.043053
0.02544
0.029354
0.031311
0.046967
0.041096
0.017613
0.021526
0.029354
1
12,267
A
T
T
T
C
C
A
G
G
C
A
T
C
G
T
G
G
A
G
G
A
C
T
A
T
A
G
A
C
C
A
C
C
C
T
T
C
T
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T
G
A
T
G
T
G
G
T
G
C
C
C
A
A
T
G
A
C
C
C
C
A
G
C
T
T
0.027397
0.017613
0.023483
0.02544
0.041096
0.041096
0.005871
0.02544
0.048924
0.023483
0.052838
0.023483
0.023483
0.048924
0.021526
0.048924
0.052838
0.068493
0.048924
0.007828
0.001957
0.003914
0.031311
0.043053
0.02544
0.029354
0.031311
0.046967
0.041096
0.017613
0.021526
0.029354
1
12,268
T
G
T
C
C
T
C
A
A
A
G
C
T
G
G
G
G
T
C
A
T
T
G
G
G
C
A
C
C
A
C
A
T
C
A
T
A
G
A
A
G
G
G
T
G
G
T
C
T
A
T
A
G
T
C
C
T
C
C
A
C
G
A
T
G
A
0.02544
0.019569
0.021526
0.02544
0.039139
0.043053
0.005871
0.023483
0.048924
0.023483
0.054795
0.023483
0.023483
0.04501
0.021526
0.046967
0.054795
0.07045
0.052838
0.007828
0.001957
0.003914
0.031311
0.043053
0.02544
0.029354
0.031311
0.050881
0.041096
0.015656
0.019569
0.029354
1
12,269
T
G
A
C
C
C
C
A
G
C
T
T
T
G
A
G
G
A
C
A
T
G
A
A
G
A
A
G
G
T
G
G
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G
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G
T
G
T
G
G
A
T
C
A
G
C
A
G
A
C
C
C
C
C
A
C
C
A
T
C
C
C
T
A
C
0.021526
0.015656
0.023483
0.02544
0.029354
0.04501
0.005871
0.023483
0.048924
0.023483
0.058708
0.019569
0.02544
0.043053
0.017613
0.043053
0.056751
0.074364
0.064579
0.007828
0.001957
0.003914
0.031311
0.04501
0.02544
0.031311
0.02544
0.050881
0.04501
0.013699
0.021526
0.031311
1
12,270
T
G
A
A
G
A
A
G
G
T
G
G
T
G
T
G
T
G
T
G
G
A
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C
A
G
C
A
G
A
C
C
C
C
C
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C
C
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C
C
C
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A
C
C
G
G
C
T
G
G
C
T
G
C
A
G
A
C
C
C
G
T
0.021526
0.013699
0.027397
0.021526
0.029354
0.048924
0.005871
0.019569
0.048924
0.023483
0.064579
0.019569
0.02544
0.039139
0.017613
0.046967
0.056751
0.074364
0.066536
0.007828
0.001957
0.003914
0.027397
0.04501
0.031311
0.029354
0.023483
0.050881
0.046967
0.013699
0.013699
0.033268
1
12,271
C
C
C
A
C
G
C
C
A
T
C
C
T
A
G
T
C
C
C
A
G
C
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C
C
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C
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C
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C
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C
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C
C
A
G
C
C
G
G
T
T
A
G
G
G
A
T
G
G
T
G
G
T
0.021526
0.011742
0.029354
0.015656
0.033268
0.048924
0.005871
0.019569
0.052838
0.027397
0.064579
0.015656
0.027397
0.035225
0.015656
0.052838
0.058708
0.076321
0.064579
0.007828
0.001957
0.003914
0.029354
0.04501
0.031311
0.029354
0.019569
0.054795
0.04501
0.011742
0.009785
0.033268
1
12,272
C
A
C
C
A
T
C
C
C
T
A
A
C
C
G
G
C
T
G
G
C
T
G
C
A
G
A
C
C
C
G
G
T
G
A
G
G
C
C
T
C
T
G
C
T
G
G
G
A
C
T
A
G
G
A
T
G
G
C
G
T
G
G
G
G
G
0.021526
0.011742
0.029354
0.015656
0.033268
0.048924
0.005871
0.019569
0.052838
0.027397
0.062622
0.015656
0.027397
0.035225
0.015656
0.054795
0.058708
0.076321
0.064579
0.007828
0.001957
0.003914
0.029354
0.04501
0.031311
0.029354
0.019569
0.054795
0.04501
0.011742
0.009785
0.033268
1
12,273
A
G
C
G
C
G
G
T
G
A
G
T
C
G
G
G
C
A
G
A
G
G
G
G
T
T
T
G
G
G
T
A
C
C
A
G
C
A
C
T
C
C
C
G
C
A
T
C
A
T
C
T
G
A
G
C
T
A
G
G
C
C
T
G
A
A
0.02544
0.005871
0.027397
0.015656
0.019569
0.037182
0
0.017613
0.078278
0.035225
0.060665
0.007828
0.031311
0.027397
0.017613
0.039139
0.056751
0.046967
0.082192
0.015656
0.007828
0.015656
0.017613
0.09002
0.023483
0.015656
0.048924
0.037182
0.048924
0.013699
0.007828
0.02544
1
12,274
T
C
A
G
A
T
G
A
T
G
C
G
G
G
A
G
T
G
C
T
G
G
T
A
C
C
C
A
A
A
C
C
C
C
T
C
T
G
C
C
C
G
A
C
T
C
A
C
C
G
C
G
C
T
G
C
G
G
A
T
C
A
A
G
A
T
0.02544
0.005871
0.023483
0.015656
0.017613
0.035225
0
0.015656
0.076321
0.041096
0.060665
0.007828
0.031311
0.027397
0.015656
0.035225
0.062622
0.046967
0.084149
0.015656
0.007828
0.015656
0.017613
0.09002
0.02544
0.013699
0.048924
0.039139
0.048924
0.013699
0.007828
0.027397
1
12,275
G
A
T
G
C
G
G
G
A
G
T
G
C
T
G
G
T
A
C
C
C
A
A
A
C
C
C
C
T
C
T
G
C
C
C
G
A
C
T
C
A
C
C
G
C
G
C
T
G
C
G
G
A
T
C
A
A
G
A
A
G
A
C
A
C
A
0.02544
0.007828
0.023483
0.015656
0.017613
0.037182
0
0.015656
0.074364
0.041096
0.060665
0.007828
0.031311
0.027397
0.015656
0.035225
0.064579
0.046967
0.084149
0.015656
0.007828
0.015656
0.017613
0.088063
0.023483
0.013699
0.048924
0.039139
0.046967
0.013699
0.007828
0.029354
1