row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
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string
f_8_ref__24
string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_33_ref__1
string
f_34_ref__2
string
f_35_ref__3
string
f_36_ref__4
string
f_37_ref__5
string
f_38_ref__6
string
f_39_ref__7
string
f_40_ref__8
string
f_41_ref__9
string
f_42_ref__10
string
f_43_ref__11
string
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string
f_45_ref__13
string
f_46_ref__14
string
f_47_ref__15
string
f_48_ref__16
string
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string
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string
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string
f_52_ref__20
string
f_53_ref__21
string
f_54_ref__22
string
f_55_ref__23
string
f_56_ref__24
string
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string
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string
f_59_ref__27
string
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string
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string
f_62_ref__30
string
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string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
12,476
G
C
C
G
C
C
A
A
T
G
A
G
G
T
C
G
G
G
G
G
T
C
T
C
G
A
A
G
A
T
G
T
C
C
A
G
C
G
C
C
T
C
C
T
C
G
G
C
G
T
C
G
C
G
G
T
G
C
T
G
C
C
G
G
T
A
0.003914
0.013699
0.029354
0.009785
0.009785
0.033268
0.023483
0.017613
0.033268
0.039139
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0.013699
0.017613
0.017613
0.019569
0.050881
0.039139
0.076321
0.07045
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0.058708
0.007828
0.046967
0.031311
0.041096
0.048924
0.088063
0.033268
0.009785
0.003914
0.007828
1
12,477
T
C
T
C
G
T
C
G
A
T
G
C
C
C
C
A
G
A
A
G
G
C
C
A
G
C
T
C
C
T
C
C
T
C
G
A
A
G
A
G
C
G
G
C
C
C
G
C
A
C
A
C
G
T
C
T
G
C
G
G
G
G
C
A
G
C
0.001957
0.005871
0.021526
0.007828
0.013699
0.027397
0.023483
0.011742
0.02544
0.046967
0.039139
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0.017613
0.013699
0.021526
0.050881
0.033268
0.074364
0.09002
0.062622
0.082192
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0.04501
0.021526
0.043053
0.050881
0.107632
0.027397
0.005871
0.001957
0.005871
1
12,478
C
T
C
A
A
T
T
A
C
T
A
C
C
G
C
A
C
C
G
G
C
A
A
G
C
T
G
C
A
C
T
G
C
C
C
C
G
C
A
G
A
C
G
T
G
T
G
C
G
G
G
C
C
G
C
T
C
T
T
C
G
A
G
G
A
G
0.001957
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0.021526
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0.011742
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0.02544
0.013699
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0.046967
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0.072407
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0.005871
0.04501
0.017613
0.046967
0.046967
0.107632
0.027397
0.005871
0.001957
0.007828
1
12,479
G
T
A
A
T
G
T
A
A
C
A
A
G
A
T
C
T
C
A
A
A
A
T
T
A
C
C
A
C
C
T
A
C
T
G
G
C
A
A
A
A
C
A
C
A
A
C
C
A
G
C
T
G
G
C
A
T
A
G
A
T
G
A
G
G
G
0.07045
0.041096
0.043053
0.060665
0.041096
0.033268
0.003914
0.035225
0.035225
0.033268
0.023483
0.046967
0.021526
0.04501
0.043053
0.015656
0.043053
0.04501
0.015656
0.001957
0.003914
0.001957
0.02544
0.013699
0.048924
0.013699
0.027397
0.011742
0.02544
0.043053
0.052838
0.033268
1
12,480
A
T
C
A
G
T
G
G
T
T
G
A
G
T
G
T
T
T
A
T
C
A
T
C
A
G
A
A
G
A
A
G
T
T
T
C
T
C
T
T
A
T
C
C
G
G
A
G
G
A
T
C
A
T
T
G
G
T
C
T
T
T
C
T
C
A
0.074364
0.035225
0.039139
0.050881
0.046967
0.027397
0
0.033268
0.050881
0.019569
0.019569
0.043053
0.041096
0.060665
0.033268
0.041096
0.031311
0.039139
0.003914
0.005871
0.005871
0.003914
0.027397
0.02544
0.048924
0.013699
0.035225
0.011742
0.02544
0.017613
0.043053
0.04501
1
12,481
A
T
C
T
A
C
A
T
A
G
T
C
A
G
A
A
T
G
T
A
A
A
A
T
T
G
C
T
C
A
T
A
T
C
T
A
G
T
G
T
G
A
A
A
C
A
A
C
C
A
G
A
T
T
T
A
G
T
T
A
G
T
T
A
T
G
0.076321
0.031311
0.039139
0.046967
0.046967
0.029354
0
0.029354
0.056751
0.021526
0.023483
0.041096
0.048924
0.046967
0.027397
0.043053
0.046967
0.041096
0.005871
0.005871
0.003914
0.005871
0.02544
0.019569
0.054795
0.011742
0.027397
0.015656
0.02544
0.019569
0.035225
0.046967
1
12,482
G
G
G
A
A
G
A
A
A
T
A
A
T
C
A
T
A
A
A
T
T
T
A
T
T
T
C
A
C
A
G
T
T
G
A
T
G
T
G
T
G
A
C
T
A
C
T
T
T
T
T
C
A
A
G
T
G
T
A
T
G
A
C
T
T
C
0.086106
0.029354
0.041096
0.050881
0.052838
0.02544
0.007828
0.037182
0.056751
0.021526
0.017613
0.029354
0.027397
0.039139
0.035225
0.043053
0.035225
0.04501
0.009785
0.005871
0.005871
0.003914
0.029354
0.027397
0.056751
0.023483
0.013699
0.011742
0.031311
0.027397
0.031311
0.041096
1
12,483
G
A
T
G
G
T
G
C
A
A
A
A
A
C
A
T
T
T
A
T
T
A
T
C
T
T
T
C
T
T
T
G
C
C
A
T
T
T
G
C
T
T
A
G
A
G
G
A
C
T
T
C
A
T
G
C
A
A
T
C
A
C
A
G
A
G
0.109589
0.033268
0.048924
0.043053
0.048924
0.017613
0.009785
0.023483
0.060665
0.02544
0.027397
0.031311
0.027397
0.04501
0.039139
0.029354
0.027397
0.043053
0.009785
0.005871
0.003914
0
0.02544
0.035225
0.050881
0.019569
0.02544
0.011742
0.04501
0.017613
0.035225
0.023483
1
12,484
T
T
G
A
G
A
T
G
A
C
T
G
G
A
A
A
C
A
C
A
G
T
C
C
A
C
T
A
T
C
A
T
C
C
T
G
T
A
C
A
A
A
A
A
A
G
A
A
A
T
A
A
A
G
C
A
A
C
T
C
A
T
T
T
T
A
0.097847
0.031311
0.04501
0.050881
0.041096
0.023483
0.007828
0.023483
0.050881
0.019569
0.031311
0.029354
0.027397
0.043053
0.041096
0.031311
0.029354
0.050881
0.021526
0.007828
0.003914
0
0.017613
0.033268
0.052838
0.017613
0.027397
0.015656
0.050881
0.017613
0.033268
0.02544
1
12,485
G
T
G
C
A
G
G
T
G
G
T
G
G
T
A
A
C
T
G
T
T
T
T
G
G
A
C
T
A
T
G
A
C
A
A
G
A
T
T
G
G
C
A
A
G
A
A
C
G
A
T
G
C
C
A
T
C
G
G
C
A
A
A
G
T
G
0.050881
0.019569
0.056751
0.041096
0.019569
0.021526
0.009785
0.041096
0.046967
0.031311
0.029354
0.04501
0.02544
0.04501
0.037182
0.023483
0.035225
0.039139
0.015656
0.011742
0.009785
0.015656
0.031311
0.02544
0.04501
0.02544
0.041096
0.037182
0.021526
0.023483
0.035225
0.043053
1
12,486
T
G
A
A
T
G
T
G
T
G
G
T
A
C
G
C
G
A
T
G
G
A
G
G
T
G
T
A
A
C
T
C
T
A
C
C
A
A
G
G
G
T
T
G
G
A
G
A
A
G
G
G
C
T
G
G
C
T
G
T
A
C
T
C
C
C
0.080235
0.033268
0.041096
0.062622
0.064579
0.021526
0.007828
0.02544
0.058708
0.023483
0.019569
0.066536
0.033268
0.043053
0.039139
0.031311
0.029354
0.021526
0.005871
0
0.003914
0.003914
0.031311
0.02544
0.043053
0.013699
0.017613
0.005871
0.013699
0.041096
0.052838
0.039139
1
12,487
G
G
C
G
G
A
A
G
G
C
A
G
C
C
A
C
T
A
T
G
C
G
C
G
A
G
C
G
G
A
G
G
C
G
C
C
T
G
A
A
G
A
A
G
G
T
C
A
A
C
C
A
G
G
C
T
T
T
C
G
A
A
A
C
C
T
0.011742
0.015656
0.027397
0.009785
0.011742
0.048924
0.015656
0.021526
0.033268
0.056751
0.060665
0.009785
0.019569
0.02544
0.02544
0.039139
0.058708
0.054795
0.033268
0.027397
0.029354
0.029354
0.023483
0.064579
0.023483
0.017613
0.056751
0.056751
0.037182
0.02544
0.003914
0.02544
1
12,488
A
G
G
T
C
A
T
C
T
G
G
G
T
C
A
A
C
T
T
T
C
A
T
T
A
T
T
T
C
T
T
T
C
C
A
G
T
T
T
A
T
A
T
T
A
G
G
T
G
G
C
A
T
C
T
T
G
A
A
T
T
C
T
T
T
A
0.097847
0.033268
0.041096
0.084149
0.04501
0.023483
0.001957
0.029354
0.035225
0.019569
0.023483
0.084149
0.023483
0.019569
0.050881
0.029354
0.037182
0.023483
0.013699
0.007828
0.001957
0
0.023483
0.005871
0.037182
0.021526
0.029354
0.017613
0.013699
0.015656
0.072407
0.037182
1
12,489
T
T
C
A
T
T
A
T
T
T
C
T
T
T
C
C
A
G
T
T
T
A
T
A
T
T
A
G
G
T
G
G
C
A
T
C
T
T
G
A
A
T
T
C
T
T
T
C
A
C
T
G
T
G
C
T
C
C
A
C
C
T
C
T
G
T
0.091977
0.031311
0.041096
0.086106
0.04501
0.021526
0.003914
0.027397
0.033268
0.023483
0.023483
0.084149
0.023483
0.021526
0.052838
0.029354
0.035225
0.023483
0.013699
0.009785
0.001957
0
0.021526
0.005871
0.037182
0.023483
0.031311
0.019569
0.015656
0.013699
0.068493
0.039139
1
12,490
C
A
T
T
A
T
T
T
C
T
T
T
C
C
A
G
T
T
T
A
T
A
T
T
A
G
G
T
G
G
C
A
T
C
T
T
G
A
A
T
T
C
T
T
T
C
A
C
T
G
T
G
C
T
C
C
A
C
C
T
C
T
G
T
A
C
0.091977
0.031311
0.041096
0.086106
0.04501
0.021526
0.003914
0.027397
0.033268
0.021526
0.023483
0.084149
0.023483
0.021526
0.052838
0.029354
0.035225
0.023483
0.013699
0.009785
0.001957
0
0.023483
0.005871
0.037182
0.023483
0.029354
0.019569
0.015656
0.013699
0.07045
0.039139
1
12,491
A
T
T
A
A
G
G
T
T
A
T
T
T
C
T
T
T
T
A
G
G
T
T
A
A
T
A
T
T
A
G
C
C
A
T
C
T
T
T
T
C
T
A
T
A
A
G
C
A
C
T
T
C
T
G
G
A
C
A
A
A
A
A
C
T
T
0.09002
0.031311
0.052838
0.060665
0.037182
0.021526
0.001957
0.039139
0.04501
0.02544
0.023483
0.054795
0.02544
0.043053
0.031311
0.015656
0.033268
0.033268
0.02544
0.001957
0
0.003914
0.027397
0.017613
0.041096
0.017613
0.021526
0.011742
0.02544
0.037182
0.072407
0.031311
1
12,492
T
G
A
A
G
A
A
T
T
C
T
T
T
A
G
A
A
T
T
T
T
T
A
A
T
A
G
A
T
C
C
A
T
T
G
A
T
G
C
C
T
T
C
A
A
G
G
A
C
T
T
T
G
T
A
G
T
G
G
C
A
T
C
T
G
C
0.080235
0.031311
0.052838
0.060665
0.04501
0.017613
0.007828
0.037182
0.068493
0.019569
0.023483
0.031311
0.043053
0.041096
0.035225
0.019569
0.029354
0.019569
0.013699
0
0
0
0.048924
0.017613
0.048924
0.017613
0.021526
0.009785
0.019569
0.039139
0.060665
0.039139
1
12,493
G
A
A
G
G
G
A
T
C
T
G
C
A
G
G
A
A
T
C
G
T
G
T
G
A
C
T
A
A
T
A
A
T
G
T
A
A
A
A
G
A
C
G
T
C
A
C
T
A
A
A
T
T
G
G
T
A
A
G
T
A
A
G
G
A
G
0.09589
0.027397
0.052838
0.062622
0.033268
0.021526
0.011742
0.037182
0.037182
0.035225
0.021526
0.035225
0.039139
0.031311
0.041096
0.035225
0.035225
0.027397
0.015656
0.001957
0.003914
0.001957
0.027397
0.015656
0.029354
0.017613
0.043053
0.009785
0.019569
0.023483
0.07045
0.039139
1
12,494
G
A
A
G
G
G
A
T
C
T
G
C
A
G
G
A
A
T
C
G
T
G
T
G
A
C
T
A
A
T
A
A
T
G
T
A
A
A
A
G
A
C
G
T
C
A
C
T
A
A
A
T
T
G
G
T
A
A
G
T
A
A
G
G
A
A
0.09589
0.027397
0.052838
0.062622
0.033268
0.021526
0.011742
0.037182
0.037182
0.035225
0.021526
0.035225
0.039139
0.031311
0.041096
0.035225
0.035225
0.027397
0.015656
0.001957
0.003914
0.001957
0.027397
0.015656
0.029354
0.017613
0.043053
0.009785
0.019569
0.023483
0.07045
0.039139
1
12,495
C
C
T
T
A
C
T
T
A
C
C
A
A
T
T
T
A
G
T
G
A
C
G
T
C
T
T
T
T
A
C
A
T
T
A
T
T
A
G
T
C
A
C
A
C
G
A
T
T
C
C
T
G
C
A
G
A
T
C
C
C
T
T
C
A
C
0.097847
0.027397
0.052838
0.062622
0.033268
0.021526
0.011742
0.037182
0.037182
0.035225
0.021526
0.035225
0.039139
0.031311
0.041096
0.035225
0.035225
0.027397
0.015656
0.001957
0.003914
0.001957
0.027397
0.015656
0.027397
0.017613
0.043053
0.009785
0.019569
0.023483
0.07045
0.039139
1
12,496
T
A
C
C
A
A
T
T
T
A
G
T
G
A
C
G
T
C
T
T
T
T
A
C
A
T
T
A
T
T
A
G
T
C
A
C
A
C
G
A
T
T
C
C
T
G
C
A
G
A
T
C
C
C
T
T
C
A
G
T
T
T
T
G
A
G
0.103718
0.027397
0.052838
0.062622
0.033268
0.021526
0.011742
0.035225
0.037182
0.035225
0.021526
0.035225
0.039139
0.031311
0.041096
0.035225
0.033268
0.027397
0.015656
0.001957
0.003914
0.001957
0.027397
0.015656
0.027397
0.015656
0.041096
0.009785
0.019569
0.023483
0.074364
0.037182
1
12,497
C
G
T
C
A
A
A
A
C
T
G
A
A
G
G
G
A
T
C
T
G
C
A
G
G
A
A
T
C
G
T
G
T
G
A
C
T
A
A
T
A
A
T
G
T
A
A
A
A
G
A
C
G
T
C
A
C
T
A
A
A
T
T
G
G
C
0.103718
0.027397
0.054795
0.062622
0.031311
0.021526
0.011742
0.035225
0.037182
0.037182
0.021526
0.035225
0.039139
0.031311
0.041096
0.033268
0.033268
0.027397
0.015656
0.001957
0.003914
0.001957
0.027397
0.015656
0.027397
0.015656
0.041096
0.009785
0.019569
0.023483
0.074364
0.037182
1
12,498
C
T
C
T
C
G
T
C
A
A
A
A
C
T
G
A
A
G
G
G
A
T
C
T
G
C
A
G
G
A
A
T
C
G
T
G
T
G
A
C
T
A
A
T
A
A
T
G
T
A
A
A
A
G
A
C
G
T
C
A
C
T
A
A
A
T
0.107632
0.027397
0.054795
0.062622
0.031311
0.021526
0.011742
0.035225
0.037182
0.035225
0.021526
0.035225
0.039139
0.031311
0.041096
0.033268
0.029354
0.027397
0.015656
0.001957
0.003914
0.001957
0.029354
0.015656
0.027397
0.015656
0.039139
0.009785
0.019569
0.023483
0.076321
0.037182
1
12,499
A
G
A
C
T
T
T
T
C
A
G
C
T
G
A
T
G
G
C
C
A
G
T
T
T
C
T
A
G
C
T
A
C
A
G
C
T
T
C
T
G
A
A
G
A
C
A
A
A
T
C
C
A
T
A
A
A
A
G
T
A
T
G
G
A
T
0.09589
0.041096
0.041096
0.056751
0.060665
0.009785
0.005871
0.043053
0.027397
0.033268
0.015656
0.062622
0.015656
0.041096
0.037182
0.021526
0.041096
0.02544
0.013699
0.003914
0.011742
0.009785
0.019569
0.019569
0.048924
0.015656
0.015656
0.011742
0.023483
0.041096
0.052838
0.037182
1
12,500
G
A
A
A
C
T
G
G
C
C
A
T
C
A
G
C
T
G
A
A
A
A
G
T
C
T
A
C
A
C
T
T
C
G
A
A
C
T
G
G
A
G
C
T
G
T
A
T
G
A
G
C
T
T
T
A
A
A
T
T
C
T
G
A
G
G
0.097847
0.041096
0.041096
0.062622
0.054795
0.011742
0.003914
0.041096
0.029354
0.031311
0.019569
0.060665
0.015656
0.04501
0.035225
0.017613
0.041096
0.027397
0.013699
0
0.011742
0.007828
0.017613
0.021526
0.056751
0.013699
0.011742
0.011742
0.023483
0.037182
0.052838
0.043053
1
12,501
T
C
A
C
T
G
C
T
A
C
T
A
C
A
T
T
A
A
C
A
G
T
A
A
G
T
T
G
G
A
A
C
T
G
A
A
G
G
A
A
T
T
T
T
G
A
G
A
T
G
C
T
G
T
C
A
T
A
G
A
C
A
T
T
T
C
0.117417
0.043053
0.048924
0.074364
0.043053
0.013699
0.003914
0.050881
0.021526
0.029354
0.023483
0.060665
0.017613
0.027397
0.035225
0.015656
0.031311
0.007828
0.013699
0.003914
0.003914
0.003914
0.029354
0.015656
0.027397
0.015656
0.021526
0.007828
0.013699
0.035225
0.105675
0.037182
1
12,502
C
T
C
T
T
G
A
T
G
G
G
A
G
A
C
C
C
T
C
A
T
C
T
G
A
C
A
G
T
T
T
G
T
T
G
T
G
A
T
T
T
A
G
T
C
T
C
A
A
A
A
A
G
G
C
C
A
C
T
T
T
A
G
G
A
C
0.066536
0.031311
0.046967
0.064579
0.046967
0.021526
0
0.027397
0.048924
0.017613
0.037182
0.019569
0.037182
0.046967
0.058708
0.021526
0.031311
0.023483
0.02544
0.003914
0.003914
0.003914
0.021526
0.031311
0.039139
0.02544
0.033268
0.019569
0.02544
0.017613
0.046967
0.054795
1
12,503
G
A
G
G
A
A
T
A
T
G
C
C
T
C
C
A
A
G
A
T
T
A
C
C
A
G
C
C
A
A
T
A
C
A
A
T
G
C
A
G
T
T
G
T
T
T
T
T
A
G
A
C
A
A
C
A
A
T
T
C
C
A
T
T
G
A
0.056751
0.031311
0.048924
0.07045
0.043053
0.027397
0
0.02544
0.050881
0.019569
0.046967
0.017613
0.037182
0.035225
0.062622
0.021526
0.031311
0.027397
0.013699
0.001957
0.003914
0.001957
0.029354
0.033268
0.04501
0.023483
0.031311
0.017613
0.031311
0.019569
0.043053
0.050881
1
12,504
G
C
T
A
A
G
A
T
G
G
A
T
A
A
A
T
C
T
A
A
A
C
A
A
G
A
A
C
A
A
A
A
T
A
A
C
C
A
A
C
T
A
C
G
G
A
A
T
T
G
A
A
A
A
A
G
G
A
G
C
C
C
T
A
A
G
0.064579
0.029354
0.060665
0.062622
0.031311
0.029354
0.001957
0.02544
0.060665
0.029354
0.043053
0.029354
0.021526
0.031311
0.048924
0.017613
0.031311
0.037182
0.013699
0.001957
0.003914
0
0.037182
0.029354
0.07045
0.023483
0.017613
0.015656
0.037182
0.017613
0.033268
0.043053
1
12,505
G
A
G
C
T
G
T
G
A
T
T
T
T
G
G
C
T
C
T
T
T
C
C
A
G
G
G
A
G
A
A
A
T
G
G
A
G
G
C
C
A
G
A
G
A
C
A
A
A
C
A
A
G
T
A
C
T
C
C
G
C
T
C
A
C
C
0.052838
0.029354
0.039139
0.048924
0.043053
0.031311
0.001957
0.021526
0.037182
0.037182
0.050881
0.017613
0.02544
0.041096
0.037182
0.023483
0.056751
0.04501
0.027397
0.007828
0.001957
0.003914
0.017613
0.033268
0.052838
0.021526
0.023483
0.02544
0.046967
0.023483
0.027397
0.046967
1
12,506
G
A
G
C
T
G
T
G
A
T
T
T
T
G
G
C
T
C
T
T
T
C
C
A
G
G
G
A
G
A
A
A
T
G
G
A
G
G
C
C
A
G
A
G
A
C
A
A
A
C
A
A
G
T
A
C
T
C
C
G
C
T
C
A
C
G
0.052838
0.029354
0.039139
0.048924
0.043053
0.031311
0.001957
0.021526
0.037182
0.037182
0.050881
0.017613
0.02544
0.041096
0.037182
0.023483
0.056751
0.04501
0.027397
0.007828
0.001957
0.003914
0.017613
0.033268
0.052838
0.021526
0.023483
0.02544
0.046967
0.023483
0.027397
0.046967
1
12,507
C
C
A
C
A
A
C
G
T
G
C
A
G
T
C
G
C
A
G
G
T
G
G
T
G
G
A
G
G
C
C
T
T
C
A
T
C
C
G
T
T
G
G
C
G
G
C
A
G
C
G
C
T
T
C
G
G
G
A
A
G
C
A
G
G
G
0.043053
0.029354
0.019569
0.011742
0.043053
0.039139
0.009785
0.019569
0.029354
0.041096
0.048924
0.005871
0.031311
0.029354
0.029354
0.050881
0.07045
0.058708
0.058708
0.023483
0.007828
0.017613
0.005871
0.043053
0.023483
0.02544
0.039139
0.043053
0.048924
0.005871
0.007828
0.039139
1
12,508
A
G
G
T
G
G
T
G
G
A
G
G
C
C
T
T
C
A
T
C
C
G
T
T
G
G
C
G
G
C
A
G
C
G
C
T
T
C
G
G
G
A
A
G
C
A
G
G
C
C
A
C
C
T
T
C
C
A
G
A
G
C
C
T
G
T
0.043053
0.029354
0.023483
0.011742
0.043053
0.039139
0.009785
0.021526
0.029354
0.041096
0.050881
0.005871
0.029354
0.027397
0.029354
0.048924
0.068493
0.056751
0.052838
0.023483
0.007828
0.017613
0.007828
0.043053
0.02544
0.027397
0.037182
0.043053
0.048924
0.007828
0.009785
0.039139
1
12,509
G
C
A
G
G
C
T
C
T
G
G
A
A
G
G
T
G
G
C
C
T
G
C
T
T
C
C
C
G
A
A
G
C
G
C
T
G
C
C
G
C
C
A
A
C
G
G
A
T
G
A
A
G
G
C
C
T
C
C
A
C
C
A
C
C
T
0.043053
0.029354
0.023483
0.011742
0.041096
0.039139
0.009785
0.021526
0.029354
0.041096
0.050881
0.005871
0.029354
0.027397
0.029354
0.048924
0.068493
0.056751
0.052838
0.023483
0.007828
0.017613
0.007828
0.043053
0.02544
0.027397
0.037182
0.04501
0.048924
0.007828
0.009785
0.039139
1
12,510
G
T
T
G
C
G
C
T
T
T
T
T
C
A
G
C
T
T
G
G
C
T
T
C
T
A
A
A
A
T
T
T
C
G
G
C
A
T
T
C
T
T
G
T
T
T
T
A
A
T
C
T
C
T
C
C
A
C
C
A
T
T
T
C
C
G
0.109589
0.02544
0.062622
0.064579
0.031311
0.015656
0
0.046967
0.054795
0.031311
0.015656
0.04501
0.019569
0.035225
0.043053
0.017613
0.023483
0.019569
0.009785
0.003914
0.001957
0.005871
0.035225
0.027397
0.048924
0.013699
0.031311
0.005871
0.017613
0.037182
0.062622
0.037182
1
12,511
C
A
G
A
G
G
C
C
A
A
G
A
G
C
A
T
G
G
C
T
C
T
G
G
C
C
G
C
C
T
A
C
C
T
G
A
A
A
A
A
A
A
C
C
C
G
T
A
G
A
T
A
G
C
C
T
C
G
G
A
G
A
C
C
G
T
0.023483
0.015656
0.035225
0.005871
0.015656
0.037182
0.021526
0.011742
0.052838
0.052838
0.043053
0.013699
0.023483
0.015656
0.02544
0.031311
0.060665
0.056751
0.056751
0.041096
0.017613
0.04501
0.017613
0.046967
0.029354
0.029354
0.037182
0.068493
0.035225
0.009785
0.001957
0.021526
1
12,512
A
T
G
C
T
G
T
A
T
G
T
G
T
T
G
T
G
C
C
A
C
A
G
C
T
A
A
T
A
A
T
T
C
C
T
C
C
A
A
G
T
C
C
A
C
A
A
A
G
G
A
T
A
A
A
G
A
A
T
C
T
G
C
C
A
T
0.080235
0.033268
0.035225
0.054795
0.048924
0.015656
0
0.04501
0.04501
0.031311
0.019569
0.050881
0.033268
0.043053
0.031311
0.031311
0.054795
0.039139
0.003914
0
0
0
0.029354
0.021526
0.037182
0.019569
0.031311
0.017613
0.02544
0.02544
0.054795
0.041096
1
12,513
A
A
T
T
C
A
A
A
C
C
C
A
G
C
C
A
G
G
T
T
A
T
G
C
C
A
A
C
A
C
T
T
T
G
A
G
G
G
A
T
G
C
A
G
C
T
C
C
C
A
A
A
A
T
G
T
A
T
A
A
G
G
A
A
G
G
0.099804
0.035225
0.046967
0.037182
0.041096
0.011742
0.007828
0.041096
0.027397
0.043053
0.033268
0.033268
0.017613
0.02544
0.043053
0.035225
0.043053
0.033268
0.019569
0.007828
0.009785
0.013699
0.019569
0.033268
0.041096
0.013699
0.031311
0.033268
0.029354
0.017613
0.035225
0.039139
1
12,514
A
G
C
A
G
C
A
G
G
A
G
G
A
A
G
A
A
C
C
C
C
A
G
G
T
G
G
A
C
G
T
A
T
G
G
G
A
G
T
T
G
C
T
G
A
A
G
A
A
C
G
C
G
A
A
A
C
C
C
A
G
T
G
A
G
C
0.027397
0.027397
0.054795
0.009785
0.009785
0.037182
0.015656
0.041096
0.041096
0.046967
0.043053
0.011742
0.011742
0.021526
0.021526
0.027397
0.046967
0.035225
0.052838
0.023483
0.02544
0.041096
0.021526
0.048924
0.050881
0.023483
0.043053
0.02544
0.037182
0.02544
0.019569
0.031311
1
12,515
G
G
G
A
G
T
T
G
C
T
G
A
A
G
A
A
C
G
C
G
A
A
A
C
C
C
A
G
T
G
A
G
T
A
C
G
A
G
A
A
G
A
T
C
G
C
C
T
T
C
C
A
G
T
A
T
G
G
A
A
T
C
A
C
C
C
0.02544
0.027397
0.054795
0.007828
0.007828
0.039139
0.019569
0.037182
0.041096
0.052838
0.043053
0.007828
0.007828
0.019569
0.021526
0.023483
0.050881
0.035225
0.054795
0.02544
0.02544
0.043053
0.019569
0.050881
0.050881
0.029354
0.041096
0.023483
0.041096
0.023483
0.017613
0.031311
1
12,516
G
T
C
G
G
T
G
A
T
T
C
C
A
T
A
C
T
G
G
A
A
G
G
C
G
A
T
C
T
T
C
T
C
G
T
A
C
T
C
A
C
T
G
G
G
T
T
T
C
G
C
G
T
T
C
T
T
C
A
G
C
A
A
C
T
T
0.02544
0.029354
0.054795
0.007828
0.007828
0.039139
0.019569
0.037182
0.041096
0.052838
0.043053
0.007828
0.007828
0.019569
0.021526
0.023483
0.050881
0.035225
0.054795
0.02544
0.02544
0.043053
0.019569
0.050881
0.050881
0.029354
0.041096
0.023483
0.041096
0.021526
0.017613
0.031311
1
12,517
T
G
G
T
G
T
C
T
T
G
T
C
T
G
A
C
A
G
A
G
A
A
A
T
C
C
G
A
A
C
A
C
T
G
G
C
T
A
C
C
A
G
A
A
T
T
C
A
C
G
A
A
C
T
G
C
C
G
T
T
A
A
G
T
T
C
0.060665
0.033268
0.027397
0.052838
0.043053
0.023483
0.013699
0.033268
0.050881
0.023483
0.021526
0.043053
0.031311
0.033268
0.041096
0.033268
0.056751
0.033268
0.011742
0.013699
0.007828
0.011742
0.013699
0.031311
0.039139
0.027397
0.039139
0.023483
0.021526
0.021526
0.033268
0.048924
1
12,518
T
T
T
A
G
T
T
A
G
T
C
C
C
A
T
A
A
C
A
C
T
T
C
T
T
C
C
A
G
A
G
G
C
G
G
A
A
A
T
C
C
T
T
T
T
T
G
A
G
G
A
T
A
T
T
C
C
C
A
A
A
G
A
A
A
G
0.07045
0.037182
0.043053
0.054795
0.039139
0.019569
0.011742
0.035225
0.035225
0.015656
0.035225
0.029354
0.027397
0.041096
0.050881
0.033268
0.029354
0.04501
0.021526
0.003914
0.009785
0.005871
0.013699
0.035225
0.056751
0.021526
0.02544
0.015656
0.048924
0.013699
0.029354
0.04501
1
12,519
C
C
T
G
G
C
T
C
G
C
T
G
A
T
A
A
G
T
T
C
T
G
T
G
A
C
C
A
A
G
C
A
T
G
C
A
A
T
G
T
C
T
T
G
T
C
C
T
G
T
G
G
G
T
T
T
G
A
T
G
C
T
G
G
C
C
0.056751
0.041096
0.035225
0.04501
0.060665
0.021526
0.001957
0.037182
0.043053
0.021526
0.039139
0.029354
0.027397
0.027397
0.046967
0.029354
0.058708
0.043053
0.019569
0.001957
0.009785
0.009785
0.009785
0.037182
0.035225
0.023483
0.031311
0.019569
0.043053
0.029354
0.037182
0.027397
1
12,520
C
T
G
G
C
C
A
G
A
C
A
T
C
C
T
T
C
C
C
A
A
A
C
A
T
G
A
C
A
T
C
A
T
C
A
T
T
T
A
G
G
T
A
A
A
T
A
A
A
C
T
T
C
T
G
G
G
A
C
A
G
C
C
C
T
G
0.080235
0.027397
0.050881
0.035225
0.035225
0.033268
0.001957
0.035225
0.033268
0.02544
0.050881
0.011742
0.027397
0.041096
0.039139
0.035225
0.029354
0.043053
0.033268
0.001957
0.009785
0.005871
0.031311
0.033268
0.048924
0.021526
0.017613
0.02544
0.039139
0.021526
0.02544
0.048924
1
12,521
T
C
A
T
C
G
C
A
T
C
G
A
A
G
G
G
C
T
G
T
C
C
C
A
G
A
A
G
T
T
T
A
T
T
T
A
C
C
T
A
A
A
T
G
A
T
G
A
T
G
T
C
A
T
G
T
T
T
G
G
G
A
A
G
G
C
0.080235
0.027397
0.046967
0.035225
0.039139
0.035225
0.001957
0.037182
0.033268
0.019569
0.052838
0.011742
0.027397
0.039139
0.037182
0.039139
0.031311
0.043053
0.033268
0.001957
0.009785
0.005871
0.031311
0.033268
0.046967
0.021526
0.015656
0.02544
0.037182
0.02544
0.02544
0.048924
1
12,522
T
G
A
A
A
G
T
C
A
C
A
T
T
C
A
T
C
G
C
A
T
C
G
A
A
G
G
G
C
T
G
T
C
C
C
A
G
A
A
G
T
T
T
A
T
T
T
A
C
C
T
A
A
A
T
G
A
T
G
A
T
G
T
C
A
T
0.082192
0.02544
0.048924
0.035225
0.039139
0.031311
0.001957
0.037182
0.035225
0.021526
0.052838
0.011742
0.027397
0.039139
0.035225
0.039139
0.031311
0.041096
0.031311
0.001957
0.009785
0.005871
0.033268
0.033268
0.048924
0.019569
0.017613
0.02544
0.037182
0.02544
0.027397
0.046967
1
12,523
C
T
T
T
T
T
T
T
G
T
T
T
G
T
T
G
T
T
G
T
T
A
A
A
A
G
G
A
T
G
T
T
T
T
T
C
G
A
A
A
T
T
T
G
A
G
C
C
A
C
T
T
G
C
C
T
A
C
C
T
T
T
A
G
T
C
0.09002
0.027397
0.050881
0.046967
0.046967
0.023483
0.001957
0.039139
0.039139
0.019569
0.048924
0.013699
0.02544
0.035225
0.039139
0.033268
0.031311
0.027397
0.023483
0
0.013699
0.003914
0.035225
0.031311
0.052838
0.023483
0.017613
0.017613
0.033268
0.027397
0.033268
0.046967
1
12,524
T
C
C
G
A
A
C
C
C
A
T
G
G
T
G
C
A
T
G
C
C
T
C
T
C
G
A
T
A
G
A
T
C
G
C
A
A
T
G
A
G
T
A
C
C
T
C
A
G
T
T
C
T
T
C
G
T
T
A
T
C
T
T
C
A
T
0.080235
0.019569
0.052838
0.052838
0.031311
0.027397
0.007828
0.027397
0.056751
0.013699
0.046967
0.033268
0.027397
0.039139
0.031311
0.021526
0.035225
0.027397
0.019569
0.005871
0.015656
0.001957
0.019569
0.037182
0.056751
0.02544
0.031311
0.015656
0.037182
0.027397
0.037182
0.037182
1
12,525
A
T
A
C
C
T
G
T
G
G
G
A
C
A
G
G
C
A
G
G
T
A
T
A
G
G
T
C
T
G
T
C
T
C
T
G
C
A
G
G
A
G
C
T
T
G
A
A
C
A
G
C
A
T
C
A
C
C
C
C
T
T
C
A
C
C
0.011742
0.011742
0.011742
0.009785
0.019569
0.027397
0.023483
0.009785
0.019569
0.04501
0.046967
0.013699
0.011742
0.019569
0.011742
0.02544
0.046967
0.02544
0.054795
0.091977
0.035225
0.099804
0.007828
0.054795
0.017613
0.029354
0.033268
0.107632
0.033268
0.013699
0.003914
0.02544
1
12,526
G
T
A
T
A
G
G
T
C
T
G
T
C
T
C
T
G
C
A
G
G
A
G
C
T
T
G
A
A
C
A
G
C
A
T
C
A
C
C
C
C
T
T
C
A
C
C
G
C
C
A
C
G
C
C
A
C
G
C
C
C
C
G
A
G
G
0.011742
0.011742
0.011742
0.009785
0.019569
0.027397
0.023483
0.009785
0.019569
0.041096
0.04501
0.013699
0.007828
0.019569
0.011742
0.02544
0.043053
0.02544
0.054795
0.103718
0.033268
0.103718
0.007828
0.052838
0.017613
0.029354
0.033268
0.11546
0.031311
0.013699
0.003914
0.021526
1
12,527
C
C
T
C
G
G
G
G
C
G
T
G
G
C
G
T
G
G
C
G
G
T
G
A
A
G
G
G
G
T
G
A
T
G
C
T
G
T
T
C
A
A
G
C
T
C
C
T
G
C
A
G
A
G
A
C
A
G
A
C
C
T
A
T
A
C
0.011742
0.011742
0.011742
0.009785
0.019569
0.027397
0.023483
0.009785
0.019569
0.041096
0.04501
0.013699
0.007828
0.019569
0.011742
0.02544
0.043053
0.02544
0.054795
0.103718
0.033268
0.105675
0.007828
0.050881
0.017613
0.029354
0.033268
0.11546
0.031311
0.013699
0.003914
0.021526
1
12,528
C
T
T
T
G
T
A
G
G
T
G
A
A
A
T
T
G
G
A
A
T
C
C
T
T
T
G
C
A
G
T
G
C
C
C
T
C
C
A
G
A
A
A
A
T
A
A
A
G
T
A
A
A
G
C
C
A
T
G
G
A
C
A
G
A
A
0.088063
0.019569
0.058708
0.050881
0.035225
0.019569
0
0.033268
0.039139
0.031311
0.027397
0.035225
0.041096
0.048924
0.04501
0.02544
0.033268
0.04501
0.02544
0.001957
0.001957
0
0.013699
0.02544
0.037182
0.017613
0.027397
0.019569
0.035225
0.02544
0.046967
0.04501
1
12,529
C
T
G
T
C
C
A
T
G
G
C
T
T
T
A
C
T
T
T
A
T
T
T
T
C
T
G
G
A
G
G
G
C
A
C
T
G
C
A
A
A
G
G
A
T
T
C
C
A
A
T
T
T
C
A
C
C
T
A
C
A
A
A
G
A
T
0.088063
0.019569
0.058708
0.050881
0.035225
0.019569
0
0.033268
0.039139
0.031311
0.027397
0.035225
0.039139
0.048924
0.04501
0.02544
0.033268
0.04501
0.02544
0.001957
0.001957
0
0.013699
0.02544
0.039139
0.017613
0.027397
0.019569
0.035225
0.02544
0.046967
0.04501
1
12,530
G
C
T
G
C
T
G
G
G
T
A
T
T
G
T
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
0.066536
0.021526
0.058708
0.048924
0.039139
0.035225
0.005871
0.029354
0.043053
0.02544
0.046967
0.021526
0.011742
0.031311
0.033268
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.046967
0.02544
0.013699
0.029354
0.035225
0.033268
0.048924
0.029354
1
12,531
C
T
G
G
G
T
A
T
T
G
T
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
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T
G
G
G
T
C
G
T
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G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
0.062622
0.021526
0.058708
0.048924
0.041096
0.035225
0.005871
0.029354
0.043053
0.02544
0.046967
0.023483
0.011742
0.033268
0.033268
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.02544
0.013699
0.029354
0.033268
0.035225
0.048924
0.029354
1
12,532
T
A
C
C
T
C
G
G
C
C
C
T
T
C
T
C
A
G
T
T
C
G
C
T
A
C
G
A
C
C
C
A
T
A
C
A
C
C
C
A
A
A
G
G
A
T
T
G
A
G
G
T
C
T
T
G
G
A
C
A
A
T
A
C
C
C
0.060665
0.021526
0.056751
0.048924
0.043053
0.035225
0.005871
0.029354
0.043053
0.02544
0.04501
0.023483
0.011742
0.033268
0.035225
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.02544
0.013699
0.029354
0.033268
0.037182
0.048924
0.029354
1
12,533
T
G
T
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
A
0.062622
0.023483
0.056751
0.048924
0.043053
0.035225
0.005871
0.029354
0.043053
0.02544
0.04501
0.023483
0.011742
0.033268
0.035225
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.037182
0.048924
0.029354
1
12,534
G
T
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
G
A
0.062622
0.023483
0.056751
0.048924
0.043053
0.035225
0.005871
0.029354
0.043053
0.02544
0.04501
0.023483
0.011742
0.035225
0.033268
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.037182
0.048924
0.029354
1
12,535
G
T
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
G
T
0.062622
0.023483
0.056751
0.048924
0.043053
0.035225
0.005871
0.029354
0.043053
0.02544
0.04501
0.023483
0.011742
0.035225
0.033268
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.037182
0.048924
0.029354
1
12,536
C
C
A
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
G
C
A
C
0.062622
0.023483
0.054795
0.048924
0.043053
0.035225
0.005871
0.029354
0.043053
0.02544
0.043053
0.027397
0.011742
0.035225
0.033268
0.029354
0.031311
0.043053
0.031311
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.037182
0.048924
0.029354
1
12,537
A
G
A
C
C
T
C
A
A
T
C
C
T
T
T
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
G
C
A
G
C
A
G
0.062622
0.023483
0.054795
0.048924
0.043053
0.033268
0.005871
0.029354
0.043053
0.02544
0.043053
0.033268
0.011742
0.035225
0.033268
0.029354
0.031311
0.043053
0.029354
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.035225
0.048924
0.029354
1
12,538
T
T
G
C
T
G
C
C
A
C
A
A
T
A
C
C
T
C
G
G
C
C
C
T
T
C
T
C
A
G
T
T
C
G
C
T
A
C
G
A
C
C
C
A
T
A
C
A
C
C
C
A
A
A
G
G
A
T
T
G
A
G
G
T
C
A
0.062622
0.023483
0.054795
0.048924
0.043053
0.033268
0.005871
0.029354
0.043053
0.02544
0.043053
0.033268
0.011742
0.035225
0.033268
0.029354
0.031311
0.043053
0.029354
0.007828
0.015656
0.005871
0.015656
0.039139
0.04501
0.023483
0.013699
0.029354
0.031311
0.037182
0.046967
0.029354
1
12,539
G
G
G
T
G
T
A
T
G
G
G
T
C
G
T
A
G
C
G
A
A
C
T
G
A
G
A
A
G
G
G
C
C
G
A
G
G
T
A
T
T
G
T
G
G
C
A
G
C
A
A
A
G
T
T
C
C
T
A
A
G
A
C
C
A
T
0.060665
0.02544
0.052838
0.046967
0.048924
0.031311
0.005871
0.029354
0.041096
0.02544
0.041096
0.035225
0.011742
0.039139
0.031311
0.031311
0.029354
0.043053
0.029354
0.007828
0.015656
0.005871
0.017613
0.039139
0.043053
0.021526
0.013699
0.029354
0.031311
0.037182
0.050881
0.027397
1
12,540
T
T
G
G
T
C
T
T
A
G
G
A
A
C
T
T
T
G
C
T
G
C
C
A
C
A
A
T
A
C
C
T
C
G
G
C
C
C
T
T
C
T
C
A
G
T
T
C
G
C
T
A
C
G
A
C
C
C
A
T
A
C
A
C
C
T
0.060665
0.02544
0.052838
0.046967
0.046967
0.031311
0.005871
0.031311
0.041096
0.02544
0.041096
0.035225
0.011742
0.039139
0.031311
0.031311
0.029354
0.043053
0.029354
0.007828
0.015656
0.005871
0.017613
0.039139
0.043053
0.021526
0.013699
0.029354
0.031311
0.037182
0.050881
0.027397
1
12,541
T
C
A
A
G
C
C
T
G
T
G
G
T
T
T
T
G
G
T
C
T
T
A
G
G
A
A
C
T
T
T
G
C
T
G
C
C
A
C
A
A
T
A
C
C
T
C
G
G
C
C
C
T
T
C
T
C
A
G
T
T
C
G
C
T
T
0.060665
0.023483
0.050881
0.046967
0.046967
0.031311
0.005871
0.029354
0.037182
0.027397
0.043053
0.035225
0.011742
0.039139
0.031311
0.031311
0.031311
0.04501
0.033268
0.007828
0.015656
0.005871
0.017613
0.039139
0.039139
0.021526
0.013699
0.031311
0.033268
0.037182
0.050881
0.02544
1
12,542
G
A
G
C
T
A
G
T
G
G
C
T
C
A
C
C
T
T
T
G
T
C
A
C
C
A
C
C
T
C
A
C
C
T
T
A
C
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
0.031311
0.029354
0.039139
0.019569
0.039139
0.035225
0.009785
0.037182
0.048924
0.029354
0.046967
0.013699
0.023483
0.029354
0.033268
0.048924
0.054795
0.060665
0.048924
0.005871
0.001957
0.001957
0.015656
0.050881
0.035225
0.021526
0.029354
0.037182
0.043053
0.021526
0.019569
0.037182
1
12,543
T
T
T
G
T
C
A
C
C
A
C
C
T
C
A
C
C
T
T
A
C
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
0.033268
0.027397
0.037182
0.021526
0.039139
0.033268
0.009785
0.035225
0.046967
0.033268
0.043053
0.013699
0.023483
0.031311
0.037182
0.048924
0.054795
0.064579
0.046967
0.005871
0.001957
0.001957
0.015656
0.050881
0.033268
0.019569
0.031311
0.039139
0.041096
0.021526
0.019569
0.037182
1
12,544
A
G
T
T
C
C
A
G
C
C
C
C
T
C
T
A
T
T
A
C
G
T
G
G
C
A
G
A
G
A
G
T
T
T
T
A
A
T
G
A
T
G
C
C
A
A
G
G
A
G
A
A
A
G
T
A
A
G
G
T
G
A
G
G
T
A
0.037182
0.027397
0.037182
0.02544
0.039139
0.031311
0.009785
0.035225
0.046967
0.033268
0.043053
0.013699
0.023483
0.031311
0.035225
0.046967
0.054795
0.062622
0.046967
0.005871
0.001957
0.001957
0.015656
0.050881
0.033268
0.017613
0.031311
0.039139
0.041096
0.023483
0.021526
0.035225
1
12,545
C
T
C
A
C
C
T
T
A
C
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
C
T
G
G
A
A
C
T
C
C
A
0.037182
0.027397
0.037182
0.02544
0.039139
0.029354
0.009785
0.035225
0.046967
0.033268
0.043053
0.013699
0.023483
0.031311
0.035225
0.046967
0.054795
0.060665
0.046967
0.005871
0.001957
0.001957
0.015656
0.050881
0.033268
0.017613
0.035225
0.039139
0.041096
0.023483
0.021526
0.035225
1
12,546
A
C
C
T
T
A
C
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
C
T
G
G
A
A
C
T
C
C
G
T
G
C
0.037182
0.02544
0.037182
0.02544
0.041096
0.029354
0.009785
0.035225
0.046967
0.033268
0.043053
0.013699
0.023483
0.033268
0.033268
0.048924
0.054795
0.060665
0.046967
0.005871
0.001957
0.001957
0.015656
0.050881
0.033268
0.017613
0.033268
0.039139
0.041096
0.023483
0.021526
0.035225
1
12,547
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
C
T
G
G
A
A
C
T
C
C
G
T
G
A
C
A
G
T
G
T
G
0.037182
0.021526
0.037182
0.02544
0.041096
0.031311
0.007828
0.037182
0.046967
0.033268
0.04501
0.015656
0.023483
0.033268
0.031311
0.048924
0.054795
0.060665
0.046967
0.005871
0.001957
0
0.019569
0.050881
0.031311
0.017613
0.033268
0.039139
0.041096
0.02544
0.021526
0.033268
1
12,548
T
T
T
C
T
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
C
T
G
G
A
A
C
T
C
C
G
T
G
A
C
A
G
T
G
T
T
0.037182
0.021526
0.037182
0.02544
0.041096
0.031311
0.007828
0.037182
0.046967
0.033268
0.04501
0.015656
0.023483
0.033268
0.031311
0.048924
0.054795
0.060665
0.046967
0.005871
0.001957
0
0.019569
0.050881
0.031311
0.017613
0.033268
0.039139
0.041096
0.02544
0.021526
0.033268
1
12,549
C
C
T
T
G
G
C
A
T
C
A
T
T
A
A
A
A
C
T
C
T
C
T
G
C
C
A
C
G
T
A
A
T
A
G
A
G
G
G
G
C
T
G
G
A
A
C
T
C
C
G
T
G
A
C
A
G
T
G
T
A
A
T
T
T
C
0.037182
0.023483
0.037182
0.02544
0.039139
0.031311
0.007828
0.037182
0.048924
0.033268
0.043053
0.015656
0.023483
0.033268
0.031311
0.048924
0.052838
0.060665
0.04501
0.005871
0.001957
0
0.021526
0.050881
0.033268
0.017613
0.033268
0.039139
0.039139
0.027397
0.021526
0.033268
1
12,550
A
G
A
C
A
G
C
C
A
T
C
C
A
A
A
A
T
T
A
C
A
C
T
G
T
C
A
C
G
G
A
G
T
T
C
C
A
G
C
C
C
C
T
C
T
A
T
T
A
C
G
T
G
G
C
A
G
A
G
A
G
T
T
T
T
C
0.037182
0.023483
0.039139
0.02544
0.039139
0.029354
0.007828
0.037182
0.048924
0.037182
0.041096
0.017613
0.023483
0.035225
0.031311
0.046967
0.048924
0.056751
0.04501
0.005871
0.001957
0
0.023483
0.052838
0.035225
0.015656
0.031311
0.037182
0.039139
0.027397
0.021526
0.037182
1
12,551
G
G
A
G
A
A
G
A
C
A
G
C
C
A
T
C
C
A
A
A
A
T
T
A
C
A
C
T
G
T
C
A
C
G
G
A
G
T
T
C
C
A
G
C
C
C
C
T
C
T
A
T
T
A
C
G
T
G
G
C
A
G
A
G
A
T
0.037182
0.023483
0.039139
0.02544
0.037182
0.027397
0.007828
0.037182
0.050881
0.037182
0.041096
0.017613
0.02544
0.037182
0.031311
0.043053
0.048924
0.056751
0.043053
0.005871
0.001957
0
0.02544
0.052838
0.035225
0.015656
0.031311
0.037182
0.039139
0.027397
0.023483
0.037182
1
12,552
C
T
T
G
G
G
G
C
C
T
A
C
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T
G
G
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T
G
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A
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A
A
G
A
C
A
A
0.039139
0.019569
0.041096
0.035225
0.035225
0.02544
0.005871
0.043053
0.046967
0.037182
0.041096
0.017613
0.02544
0.035225
0.031311
0.039139
0.046967
0.054795
0.041096
0.003914
0.001957
0
0.027397
0.052838
0.035225
0.013699
0.023483
0.037182
0.039139
0.035225
0.029354
0.039139
1
12,553
T
G
G
T
T
C
C
T
G
T
G
A
A
G
G
T
C
A
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A
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A
T
G
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C
T
A
0.052838
0.02544
0.029354
0.046967
0.041096
0.037182
0.001957
0.031311
0.035225
0.021526
0.039139
0.046967
0.037182
0.04501
0.041096
0.039139
0.04501
0.054795
0.033268
0.001957
0
0
0.019569
0.033268
0.033268
0.021526
0.02544
0.015656
0.041096
0.027397
0.027397
0.048924
1
12,554
C
A
T
A
A
A
G
G
C
A
T
A
T
G
G
T
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C
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T
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C
A
C
A
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G
A
0.052838
0.02544
0.031311
0.046967
0.041096
0.037182
0.001957
0.031311
0.037182
0.019569
0.039139
0.046967
0.037182
0.04501
0.041096
0.039139
0.043053
0.054795
0.035225
0.001957
0
0
0.019569
0.033268
0.035225
0.019569
0.02544
0.013699
0.043053
0.027397
0.027397
0.046967
1
12,555
C
T
C
C
A
T
A
A
A
G
G
C
A
T
A
T
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G
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A
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T
T
C
A
C
T
0.052838
0.02544
0.029354
0.046967
0.041096
0.037182
0.001957
0.031311
0.039139
0.019569
0.037182
0.046967
0.041096
0.04501
0.039139
0.039139
0.043053
0.054795
0.035225
0.001957
0
0
0.019569
0.033268
0.035225
0.019569
0.02544
0.013699
0.043053
0.027397
0.027397
0.046967
1
12,556
A
C
T
C
C
A
T
A
A
A
G
G
C
A
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A
T
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G
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A
A
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A
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A
C
C
T
T
C
A
G
0.052838
0.02544
0.031311
0.046967
0.041096
0.037182
0.001957
0.031311
0.039139
0.019569
0.037182
0.046967
0.041096
0.04501
0.039139
0.039139
0.043053
0.052838
0.035225
0.001957
0
0
0.019569
0.033268
0.035225
0.019569
0.02544
0.013699
0.043053
0.027397
0.027397
0.046967
1
12,557
G
A
G
A
C
T
C
C
A
T
A
A
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G
C
A
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A
A
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A
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T
A
T
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A
C
C
T
G
0.054795
0.02544
0.031311
0.04501
0.041096
0.037182
0.001957
0.031311
0.039139
0.019569
0.037182
0.046967
0.041096
0.04501
0.039139
0.039139
0.043053
0.052838
0.035225
0.001957
0
0
0.019569
0.033268
0.035225
0.019569
0.02544
0.013699
0.043053
0.027397
0.027397
0.046967
1
12,558
C
T
G
T
A
A
T
T
C
A
C
C
A
A
A
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G
A
T
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T
T
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G
C
A
0.054795
0.02544
0.031311
0.046967
0.043053
0.037182
0.001957
0.031311
0.039139
0.019569
0.035225
0.046967
0.039139
0.046967
0.041096
0.041096
0.041096
0.054795
0.035225
0.001957
0
0
0.019569
0.033268
0.035225
0.019569
0.02544
0.009785
0.041096
0.027397
0.027397
0.046967
1
12,559
C
A
G
G
A
G
C
C
C
A
G
C
A
C
C
A
T
A
T
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C
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A
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A
G
T
A
A
A
0.054795
0.027397
0.029354
0.048924
0.041096
0.041096
0.001957
0.031311
0.033268
0.021526
0.033268
0.043053
0.037182
0.046967
0.043053
0.041096
0.039139
0.058708
0.035225
0.003914
0
0.001957
0.019569
0.029354
0.035225
0.019569
0.02544
0.013699
0.041096
0.027397
0.027397
0.046967
1
12,560
T
C
C
A
G
A
T
T
T
A
C
T
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G
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A
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A
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T
0.054795
0.027397
0.027397
0.046967
0.039139
0.041096
0.001957
0.029354
0.035225
0.021526
0.033268
0.043053
0.041096
0.046967
0.039139
0.041096
0.043053
0.062622
0.037182
0.003914
0
0.001957
0.019569
0.029354
0.035225
0.019569
0.021526
0.013699
0.04501
0.023483
0.027397
0.046967
1
12,561
T
C
C
A
T
T
C
C
A
G
A
T
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T
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C
A
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A
A
A
G
G
G
0.054795
0.027397
0.029354
0.04501
0.039139
0.041096
0.001957
0.029354
0.035225
0.021526
0.033268
0.043053
0.041096
0.046967
0.039139
0.041096
0.043053
0.062622
0.037182
0.003914
0
0.001957
0.017613
0.029354
0.037182
0.019569
0.021526
0.013699
0.04501
0.023483
0.027397
0.046967
1
12,562
A
C
C
C
A
G
G
G
A
G
A
G
A
A
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G
G
A
C
T
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C
A
T
C
A
G
G
T
G
C
A
C
C
C
A
G
A
G
A
G
0.058708
0.031311
0.039139
0.043053
0.039139
0.039139
0
0.02544
0.04501
0.017613
0.048924
0.031311
0.037182
0.029354
0.033268
0.041096
0.046967
0.056751
0.04501
0
0.001957
0.001957
0.02544
0.02544
0.048924
0.007828
0.017613
0.033268
0.035225
0.02544
0.031311
0.037182
1
12,563
T
A
C
A
G
G
A
A
A
T
T
G
G
C
C
T
T
G
C
C
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T
G
A
A
A
A
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C
T
C
G
C
C
A
C
A
G
T
A
T
0.066536
0.029354
0.043053
0.043053
0.041096
0.035225
0
0.02544
0.043053
0.017613
0.050881
0.033268
0.035225
0.029354
0.031311
0.041096
0.04501
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.02544
0.048924
0.007828
0.015656
0.033268
0.035225
0.023483
0.035225
0.037182
1
12,564
A
T
T
A
C
A
G
G
A
A
A
T
T
G
G
C
C
T
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C
A
T
T
G
A
A
A
A
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C
T
C
G
C
C
A
C
A
G
T
0.066536
0.029354
0.041096
0.043053
0.041096
0.035225
0
0.027397
0.043053
0.015656
0.050881
0.033268
0.035225
0.029354
0.031311
0.043053
0.04501
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.02544
0.048924
0.007828
0.015656
0.033268
0.035225
0.023483
0.035225
0.037182
1
12,565
T
G
G
C
G
A
G
C
T
T
T
T
C
A
A
T
G
T
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G
G
C
C
A
A
T
T
T
C
C
T
G
T
A
A
T
T
G
G
A
0.064579
0.029354
0.041096
0.043053
0.041096
0.035225
0
0.027397
0.043053
0.015656
0.052838
0.033268
0.035225
0.029354
0.031311
0.043053
0.04501
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.027397
0.048924
0.007828
0.015656
0.033268
0.035225
0.023483
0.031311
0.039139
1
12,566
C
C
C
C
C
A
A
T
T
A
C
A
G
G
A
A
A
T
T
G
G
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C
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T
G
A
A
T
A
C
A
T
T
G
A
A
A
A
G
C
T
C
G
C
0.064579
0.029354
0.041096
0.039139
0.041096
0.035225
0
0.027397
0.043053
0.015656
0.052838
0.033268
0.035225
0.029354
0.031311
0.043053
0.04501
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.027397
0.050881
0.007828
0.015656
0.033268
0.037182
0.023483
0.031311
0.039139
1
12,567
T
A
T
T
T
T
C
C
C
C
C
A
A
T
T
A
C
A
G
G
A
A
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C
C
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G
G
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C
A
C
C
T
G
A
T
G
A
A
T
A
C
A
T
T
G
A
A
A
T
0.062622
0.029354
0.039139
0.043053
0.041096
0.035225
0
0.027397
0.041096
0.015656
0.054795
0.033268
0.035225
0.029354
0.033268
0.043053
0.04501
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.027397
0.050881
0.007828
0.015656
0.033268
0.037182
0.023483
0.027397
0.041096
1
12,568
T
T
C
A
T
C
A
G
G
T
G
C
A
C
C
C
A
G
A
G
A
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T
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C
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T
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A
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G
G
G
G
A
A
A
A
T
A
G
A
A
C
C
T
G
T
T
C
C
0.060665
0.027397
0.041096
0.043053
0.039139
0.035225
0
0.027397
0.043053
0.015656
0.054795
0.033268
0.033268
0.02544
0.033268
0.04501
0.046967
0.052838
0.04501
0
0.001957
0.001957
0.02544
0.029354
0.052838
0.007828
0.017613
0.035225
0.037182
0.021526
0.02544
0.041096
1
12,569
G
G
C
T
A
A
A
A
A
A
T
C
C
A
T
T
C
C
T
T
A
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G
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A
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G
A
T
C
T
G
A
A
A
A
C
A
A
G
G
G
C
A
C
A
G
0.058708
0.02544
0.04501
0.031311
0.033268
0.031311
0
0.023483
0.052838
0.031311
0.050881
0.023483
0.033268
0.048924
0.021526
0.027397
0.048924
0.039139
0.043053
0.005871
0.005871
0.003914
0.017613
0.046967
0.052838
0.015656
0.02544
0.021526
0.041096
0.019569
0.02544
0.048924
1
12,570
A
T
G
T
G
C
C
C
T
T
G
T
T
T
T
C
A
G
A
T
C
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C
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C
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C
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T
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A
G
G
A
A
T
G
G
A
T
T
T
T
T
T
A
G
C
A
0.058708
0.02544
0.04501
0.029354
0.033268
0.031311
0
0.023483
0.052838
0.031311
0.050881
0.023483
0.033268
0.048924
0.021526
0.027397
0.048924
0.039139
0.043053
0.005871
0.005871
0.003914
0.017613
0.046967
0.052838
0.015656
0.02544
0.021526
0.043053
0.019569
0.02544
0.048924
1
12,571
A
A
A
A
A
A
T
C
C
A
T
T
C
C
T
T
A
C
C
T
G
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A
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T
G
A
A
A
A
C
A
A
G
G
G
C
A
C
A
T
G
T
C
A
0.062622
0.02544
0.04501
0.029354
0.033268
0.031311
0
0.023483
0.052838
0.031311
0.050881
0.023483
0.033268
0.046967
0.021526
0.027397
0.048924
0.039139
0.043053
0.005871
0.005871
0.003914
0.017613
0.04501
0.054795
0.015656
0.02544
0.021526
0.043053
0.019569
0.02544
0.046967
1
12,572
G
G
G
A
C
A
T
G
T
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C
C
C
T
T
G
T
T
T
T
C
A
G
A
T
C
G
C
A
G
C
T
T
T
G
C
C
C
A
G
T
T
T
T
C
C
C
A
G
G
T
A
A
G
G
A
A
T
G
G
A
T
T
T
T
G
0.064579
0.02544
0.04501
0.031311
0.033268
0.031311
0
0.023483
0.050881
0.031311
0.050881
0.023483
0.031311
0.046967
0.021526
0.027397
0.048924
0.039139
0.043053
0.005871
0.005871
0.003914
0.017613
0.04501
0.054795
0.015656
0.02544
0.021526
0.043053
0.019569
0.02544
0.046967
1
12,573
C
A
T
T
C
C
T
T
A
C
C
T
G
G
G
A
A
A
A
C
T
G
G
G
C
A
A
A
G
C
T
G
C
G
A
T
C
T
G
A
A
A
A
C
A
A
G
G
G
C
A
C
A
T
G
T
C
C
C
A
A
C
A
G
C
T
0.064579
0.02544
0.046967
0.029354
0.033268
0.031311
0
0.021526
0.054795
0.031311
0.050881
0.02544
0.031311
0.046967
0.021526
0.027397
0.048924
0.039139
0.043053
0.005871
0.005871
0.003914
0.015656
0.046967
0.054795
0.015656
0.02544
0.021526
0.043053
0.015656
0.02544
0.046967
1
12,574
T
T
C
A
G
T
G
A
C
A
T
C
T
G
C
C
A
T
G
A
G
C
T
G
T
T
G
G
G
A
C
A
T
G
T
G
C
C
C
T
T
G
T
T
T
T
C
A
G
A
T
C
G
C
A
G
C
T
T
T
G
C
C
C
A
A
0.064579
0.023483
0.04501
0.029354
0.029354
0.035225
0
0.019569
0.052838
0.031311
0.056751
0.021526
0.031311
0.043053
0.021526
0.02544
0.050881
0.039139
0.046967
0.005871
0.005871
0.003914
0.017613
0.046967
0.050881
0.017613
0.031311
0.023483
0.043053
0.017613
0.02544
0.043053
1
12,575
A
A
A
G
C
T
G
C
G
A
T
C
T
G
A
A
A
A
C
A
A
G
G
G
C
A
C
A
T
G
T
C
C
C
A
A
C
A
G
C
T
C
A
T
G
G
C
A
G
A
T
G
T
C
A
C
T
G
A
A
A
G
A
C
A
G
0.064579
0.023483
0.04501
0.027397
0.029354
0.035225
0
0.019569
0.052838
0.035225
0.056751
0.021526
0.029354
0.043053
0.021526
0.02544
0.052838
0.039139
0.046967
0.005871
0.005871
0.003914
0.017613
0.046967
0.048924
0.017613
0.033268
0.023483
0.043053
0.017613
0.02544
0.041096
1