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A novel p.Leu213X mutation in GJB2 gene in a Portuguese family. | INTRODUCTION
Hearing loss is the most common sensory disability and is present in about 1.9 per 1000 infants at birth. The DFNB1 locus (13q11-q12) includes the genes GJB2, coding for connexin 26, and GJB6, encoding connexin 30. More than 100 mutations have been identified associated with autosomal dominant and recessiv... | 23,141,775 | D000293:Adolescent; D002648:Child; D000072259:Connexin 26; D017630:Connexins; D003638:Deafness; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006319:Hearing Loss, Sensorineural; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D010375:Pedigree; D016133:Polymeras... | International journal of pediatric otorhinolaryngology | 2,013 | D017630:Connexins; C000607042:GJB2 protein, human; D000072259:Connexin 26 | |
Identification of a mutant locus by noncomplementation of a transposon insertion library in Saccharomyces cerevisiae. | We describe a new approach for identifying the gene corresponding to a mutation in Saccharomyces cerevisiae. A library of mTn-lacZ/LEU2 insertions is tested for failure to complement the mutation, and the noncomplementing insertion is used to obtain sequence. This approach offers an alternative to cloning by complement... | 10.1093/genetics/158.4.1825 | 11,514,465 | D000483:Alleles; D004247:DNA; D004251:DNA Transposable Elements; D004171:Diploidy; D015723:Gene Library; D005816:Genetic Complementation Test; D005821:Genetic Techniques; D009154:Mutation; D016366:Open Reading Frames; D010957:Plasmids; D012441:Saccharomyces cerevisiae | Genetics | 2,001 | D004251:DNA Transposable Elements; D004247:DNA |
The association between acculturation patterns and mental health symptoms among Eritrean and Sudanese asylum seekers in Israel. | Past research has documented the role acculturation plays in the process of adjustment to new cultures among migrants. Yet little attention has been paid thus far to the role of acculturation in the context of forced migration. In this study we examined the association between acculturation patterns and mental health s... | 10.1037/a0037534 | 25,090,150 | D000069:Acculturation; D000328:Adult; D005002:Ethiopia; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D001523:Mental Disorders; D008603:Mental Health; D008875:Middle Aged; D012036:Refugees; D012959:Socioeconomic Factors; D013313:Stress Disorders, Post-Traumatic; D013397:Sudan; D011795:Surveys and Questi... | Cultural diversity & ethnic minority psychology | 2,015 | |
Glutamine metabolism links growth factor signaling to the regulation of autophagy. | Activation of the PI3K-AKT1-FOXO module by growth factors increases survival and stress resistance. We identified the gene encoding glutamine synthetase (GLUL, glutamate-ammonia ligase) as a novel transcriptional target of this signaling cascade. Growth factor removal increases glutamine synthetase expression and activ... | 10.4161/auto.22152 | 22,996,802 | D000818:Animals; D001343:Autophagy; D017173:Caenorhabditis elegans; D005974:Glutamate-Ammonia Ligase; D005973:Glutamine; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008954:Models, Biological; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases | Autophagy | 2,012 | D036341:Intercellular Signaling Peptides and Proteins; D005973:Glutamine; D058570:TOR Serine-Threonine Kinases; D005974:Glutamate-Ammonia Ligase |
Fluorescent Eimeria bovis sporozoites and meront stages in vitro: a helpful tool to study parasite-host cell interactions. | A fluorescence-based technique was established to trace intracellular sporozoites of Eimeria bovis for tests on gliding motility, invasion, replication and quantification of infection rates in cultured bovine umbilical vein endothelial cells (BUVEC) by laser scanning confocal microscopy and flow cytometry (FCM) analyse... | 10.1007/s00436-007-0849-4 | 18,175,149 | D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D003048:Coccidiosis; D004539:Eimeria; D042783:Endothelial Cells; D004730:Endothelium, Vascular; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006790:Host-Parasite Interactions; D018613:Microscopy, Confocal; D009068:Movement; D034101:Sporozoites; D014471:Umb... | Parasitology research | 2,008 | D005456:Fluorescent Dyes |
Prediction of subclinical left ventricular dysfunction with strain rate imaging in patients with mild to moderate rheumatic mitral stenosis. | BACKGROUND
Left ventricular (LV) long-axis function evaluated by Doppler tissue echocardiography-derived strain rate (SR) imaging has been shown to be a useful index of LV systolic function; however, it has not been evaluated in patients with mitral stenosis (MS). We examined the LV long-axis function of patients with ... | 10.1016/j.echo.2005.09.014 | 16,500,485 | D000328:Adult; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis; D011379:Prognosis; D015203:Reproducibility of Results; D012214:Rheumatic Heart Disease; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013318:Stroke Volu... | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography | 2,006 | |
Stable alpha- and beta-islet cell function after tolerance induction to pancreatic islet allografts in diabetic primates. | Pancreatic islet transplantation (PIT) is an attractive alternative for type 1 diabetic patients. PIT is not yet an effective clinical reality due in part to early loss of functional islet mass. In addition, current immunosuppressive drugs have toxic effects on islets and increase the risk of morbidity and mortality. P... | 10.1034/j.1600-6143.2003.00031.x | 12,603,208 | D000818:Animals; D015415:Biomarkers; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental; D005951:Glucose Tolerance Test; D006084:Graft Rejection; D006146:Guanidines; D007166:Immunosuppressive Agents; D016381:Islets of Langerhans Transplantation; D008253:Macaca mulatta; D008297:Male; D012016:Reference Values... | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 2,003 | D015415:Biomarkers; D001786:Blood Glucose; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus |
Genomic prediction for beef fatty acid profile in Nellore cattle. | The objective of this study was to compare SNP-BLUP, BayesCπ, BayesC and Bayesian Lasso methodologies to predict the direct genomic value for saturated, monounsaturated, and polyunsaturated fatty acid profile, omega 3 and 6 in the Longissimus thoracis muscle of Nellore cattle finished in feedlot. A total of 963 Nellore... | 10.1016/j.meatsci.2017.02.007 | 28,214,693 | D000818:Animals; D017849:Animals, Inbred Strains; D001499:Bayes Theorem; D001938:Brazil; D002417:Cattle; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005240:Feasibility Studies; D023281:Genomics; D006801:Humans; D008297:Male; D008460:Meat; D0089... | Meat science | 2,017 | D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D009124:Muscle Proteins |
A national survey of out-of-hours working and fatigue in consultants in anaesthesia and paediatric intensive care in the UK and Ireland. | The tragic death of an anaesthetic trainee driving home after a series of night shifts prompted a national survey of fatigue in trainee anaesthetists. This indicated that fatigue was widespread, with significant impact on trainees' health and well-being. Consultants deliver an increasing proportion of patient care resu... | 10.1111/anae.14819 | 31,478,198 | D000328:Adult; D000368:Aged; D000072080:Anesthesiologists; D002055:Burnout, Professional; D003253:Consultants; D003422:Critical Care; D003697:Delphi Technique; D005221:Fatigue; D005260:Female; D006304:Health Status; D006801:Humans; D015278:Intensive Care Units, Pediatric; D007494:Ireland; D008297:Male; D008875:Middle A... | Anaesthesia | 2,019 | |
Can high-intensity interval training and small-sided games be effective for improving physical fitness after detraining? A parallel study design in youth male soccer players. | Background
The aim of this study was two-fold: (i) analyze the within-group physical fitness adaptations promoted by a detraining period (4 weeks) followed by an intervention period (4 weeks) using small-sided games (SSGs) or running-based high intensity interval training (HIIT); and (ii) analyze the between-group diff... | 10.7717/peerj.13514 | 35,795,177 | D008297:Male; D006801:Humans; D000293:Adolescent; D012916:Soccer; D000072696:High-Intensity Interval Training; D010809:Physical Fitness; D012420:Running; D012107:Research Design; D000906:Antibodies | PeerJ | 2,022 | D000906:Antibodies |
Levels and spatial distribution of airborne chemical elements in a heavy industrial area located in the north of Spain. | The adverse health effects of airborne particles have been subjected to intense investigation in recent years; however, more studies on the chemical characterization of particles from pollution emissions are needed to (1) identify emission sources, (2) better understand the relative toxicity of particles, and (3) pinpo... | 10.1080/15287394.2014.910156 | 25,072,718 | D000336:Aerosols; D000393:Air Pollutants; D004784:Environmental Monitoring; D007221:Industry; D008011:Lichens; D019216:Metals, Heavy; D009501:Neutron Activation Analysis; D010316:Particle Size; D052638:Particulate Matter; D013030:Spain | Journal of toxicology and environmental health. Part A | 2,014 | D000336:Aerosols; D000393:Air Pollutants; D019216:Metals, Heavy; D052638:Particulate Matter |
Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing. | Cyathostome populations in horses on two farms located in central Italy with a history of fenbendazole (FBZ) resistance were investigated with the Faecal Egg Count Reduction Test to evaluate the susceptibility to oxibendazole and moxidectin. Faecal eggs were collected pre- and post-treatment on each farm and molecularl... | 10.1016/j.exppara.2008.10.001 | 18,950,625 | D000818:Animals; D000969:Antinematodal Agents; D001562:Benzimidazoles; D004351:Drug Resistance; D005243:Feces; D005273:Fenbendazole; D006736:Horses; D018942:Macrolides; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D010270:Parasite Egg Count; D021261:Parasitic Sensitivity Tests; D011897:Random All... | Experimental parasitology | 2,009 | D000969:Antinematodal Agents; D001562:Benzimidazoles; D018942:Macrolides; D015345:Oligonucleotide Probes; C011321:oxibendazole; D005273:Fenbendazole; C027837:moxidectin |
Management of early acute renal failure: focus on post-injury prevention. | PURPOSE OF REVIEW
In this review, we describe our current understanding of various aspects of secondary renal injury and its prevention. Secondary renal injury indicates any injury to the kidney, which occurs after an initial event has already triggered injury to the organ.
RECENT FINDINGS
Analysis of the literature ... | 10.1097/01.ccx.0000184165.02498.14 | 16,292,057 | D058186:Acute Kidney Injury; D001794:Blood Pressure; D002302:Cardiac Output; D006801:Humans; D019194:Ischemic Preconditioning; D007668:Kidney; D020011:Protective Agents; D012079:Renal Circulation | Current opinion in critical care | 2,005 | D020011:Protective Agents |
The impact of obesity-related SNP on appetite and energy intake. | An increasing number of studies have reported a heritable component for the regulation of energy intake and eating behaviour, although the individual polymorphisms and their ‘effect size’ are not fully elucidated. The aim of the present study was to examine the relationship between specific SNP and appetite responses a... | 10.1017/S0007114513000147 | 23,433,430 | D000293:Adolescent; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001066:Appetite; D004435:Eating; D002149:Energy Intake; D005247:Feeding Behavior; D005838:Genotype; D006801:Humans; D020738:Leptin; D008297:Male; D008875:Middle Aged; D009765:Obesity; D020641:Polymorphism, Single Nucleotide; D... | The British journal of nutrition | 2,013 | D020738:Leptin; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human |
[Molecular aspects of human hepatocellular carcinoma]. | It is now evident that development of hepatocellular carcinoma (HCC) in human is associated with a long series of cellular and tissue changes that precede the ultimate development of the cancer. During recent years, enormous progress in molecular research on HCC has been made, particularly in the area of integration of... | 2,536,267 | D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular; D004273:DNA, Neoplasm; D004279:DNA, Viral; D005260:Female; D006509:Hepatitis B; D006515:Hepatitis B virus; D006801:Humans; D008113:Liver Neoplasms; D008114:Liver Neoplasms, Experimental; D008297:Male; D008875:Middle Aged; D009857:Oncogenes... | Gan to kagaku ryoho. Cancer & chemotherapy | 1,989 | D004273:DNA, Neoplasm; D004279:DNA, Viral | |
Science, research and social change in Indigenous health--evolving ways of knowing. | History tells us of the overwhelming destructive influence of exotic culture, politics and knowledge forms upon the worldview and wellbeing of Indigenous Australians. The power of dominant culture to oppress, control and dominate traditional Indigenous ways of knowing and being has been identified as a being a crucial ... | 10.1071/ah090628 | 20,166,912 | D001315:Australia; D006304:Health Status; D006801:Humans; D044468:Native Hawaiian or Other Pacific Islander; D012106:Research; D012586:Science; D012922:Social Change | Australian health review : a publication of the Australian Hospital Association | 2,009 | |
Efficient bioremediation of tannery wastewater by monostrains and consortium of marine Chlorella sp. and Phormidium sp. | This study evaluated the bioremediation potential of two marine microalgae Chlorella sp. and Phormidium sp., both individually and in consortium, to reduce various pollutants in tannery wastewater (TW). The microalgae were grown in hazardous 100% TW for 20 days, and the reductions in biochemical oxygen demand (BOD), ch... | 10.1080/15226514.2017.1374338 | 29,053,344 | D001673:Biodegradation, Environmental; D057919:Biological Oxygen Demand Analysis; D002708:Chlorella; D010758:Phosphorus; D014865:Waste Disposal, Fluid; D062065:Wastewater; D014874:Water Pollutants, Chemical | International journal of phytoremediation | 2,018 | D062065:Waste Water; D014874:Water Pollutants, Chemical; D010758:Phosphorus |
Direct conversion of multilayer molybdenum trioxide to nanorods as multifunctional electrodes in lithium-ion batteries. | In this study we prepared molybdenum trioxide (MoO3) nanorods having average lengths of 0.5-1.5 μm and widths of approximately 100-200 nm through a one-step mechanical break-down process involving favorable fracturing along the crystal direction. We controlled the dimensions of the as-prepared nanorods by applying vari... | 10.1039/c4nr00692e | 24,728,234 | Nanoscale | 2,014 | ||
[Safety evaluation of anticancer drugs circuit in a regional hospital in Tunisia]. | INTRODUCTION
Nowadays, the circuit of drugs is a plague. This situation may cause serious harm to patients. In this context, we conducted a study with the aim to describe and evaluate the circuit of anticancer drugs in a Tunisian regional hospital.
METHODS
This is an evaluative study of the risk of anticancer drugs, ... | 10.11604/pamj.2016.23.30.8600 | 27,200,135 | D000970:Antineoplastic Agents; D004339:Drug Compounding; D004867:Equipment Design; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D014416:Tunisia | The Pan African medical journal | 2,016 | D000970:Antineoplastic Agents |
[Effectiveness of intra-arterial infusion chemotherapy for solitary bone metastasis from lung cancer with radiotherapy--a case report]. | There have been few reports on intra-arterial infusion chemotherapy for metastatic bone cancer because the bone metastasis is multiple in almost all cases. However, selective intra-arterial infusion chemotherapy is thought to be more effective than systemic chemotherapy for solitary bone metastasis. The patient was a 4... | 11,265,406 | D000230:Adenocarcinoma; D000970:Antineoplastic Agents; D001859:Bone Neoplasms; D002945:Cisplatin; D003131:Combined Modality Therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007719:Knee Joint; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage | Gan to kagaku ryoho. Cancer & chemotherapy | 2,001 | D000970:Antineoplastic Agents; D002945:Cisplatin | |
Silencing Op18/stathmin by RNA Interference Promotes the Sensitivity of Nasopharyngeal Carcinoma Cells to Taxol and High-Grade Differentiation of Xenografted Tumours in Nude Mice. | Nasopharyngeal carcinoma (NPC) is a refractory tumour, and chemotherapy is one of the primary treatment modalities. Oncoprotein 18 (Op18)/stathmin is a conserved small cytosolic phosphoprotein and highly expressed in tumours, which plays a vital role in maintaining the malignant phenotype of tumours. Taxol is a clinica... | 10.1111/bcpt.12633 | 27,289,016 | D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D017209:Apoptosis; D002277:Carcinoma; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Mal... | Basic & clinical pharmacology & toxicology | 2,016 | D000972:Antineoplastic Agents, Phytogenic; D050777:Stathmin; C493994:Stmn1 protein, mouse; D017239:Paclitaxel |
Socioeconomic Disparities and Gender Inequalities in Dementia: a Community-Dwelling Population Study from a Middle-Income Country. | The proportion of the world's older adults and of its dementia cases is increasing in low and middle-income countries. This is particularly true in Colombia. There, the number of individuals with dementia may increase five-fold by 2050. Yet research is lacking on dementia in such settings. This work estimates the preva... | 10.1007/s10823-020-09418-4 | 33,247,379 | D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D060825:Cognitive Dysfunction; D003105:Colombia; D003704:Dementia; D005260:Female; D006801:Humans; D007182:Income; D057187:Independent Living; D007843:Latin America; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D01292... | Journal of cross-cultural gerontology | 2,021 | |
Geographical variation and factors associated with unsafe child stool disposal in Ethiopia: A spatial and multilevel analysis. | BACKGROUND
Unsafe disposal of children's stool makes children susceptible to fecal-oral diseases and children remain vulnerable till the stools of all children are disposed of safely. There is a paucity of data on spatial distribution and factors associated with unsafe child stool disposal in Ethiopia. Previous estimat... | 10.1371/journal.pone.0250814 | 33,914,836 | D003430:Cross-Sectional Studies; D005002:Ethiopia; D005191:Family Characteristics; D005243:Feces; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D055361:Multilevel Analysis; D012499:Sanitation; D012959:Socioeconomic Factors; D012984:Software; D062206:Spat... | PloS one | 2,021 | |
Effect of field strength on susceptibility artifacts in magnetic resonance imaging. | In magnetic resonance imaging susceptibility artifacts occur at the interface of substances with large magnetic susceptibility differences, resulting in geometric distortions of the image at those boundaries. The susceptibility artifacts are often subtle on clinical images and if not carefully examined they may lead to... | 10.1016/0895-6111(90)90040-i | 2,272,012 | D006257:Head; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008961:Models, Structural; D012016:Reference Values | Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society | 1,990 | |
Electrochemiluminescence immunosensor based on the quenching effect of CuO@GO on m-CNNS for cTnI detection. | A sandwich-type electrochemiluminescence (ECL) immunosensor based on the resonance energy transfer (RET) was proposed for ultrasensitive detection of cardiac troponin I (cTnI). The RET behavior could be generated between graphite carbon nitride nanosheets (m-CNNS) as donor and copper oxide@graphene oxide (CuO@GO) as ac... | 10.1016/j.ab.2020.114012 | 33,189,703 | D055910:Antibodies, Immobilized; D015374:Biosensing Techniques; D003300:Copper; D055664:Electrochemical Techniques; D031541:Fluorescence Resonance Energy Transfer; D015200:Fluoroimmunoassay; D006108:Graphite; D006801:Humans; D057230:Limit of Detection; D049329:Nanostructures; D017672:Nitrogen Compounds; D015203:Reprodu... | Analytical biochemistry | 2,021 | D055910:Antibodies, Immobilized; D017672:Nitrogen Compounds; D019210:Troponin I; C000628730:graphene oxide; C000629596:graphitic carbon nitride; D006108:Graphite; D003300:Copper; C030973:cupric oxide |
Phenotyping seedlings for selection of root system architecture in alfalfa (Medicago sativa L.). | BACKGROUND
The root system architecture (RSA) of alfalfa (Medicago sativa L.) affects biomass production by influencing water and nutrient uptake, including nitrogen fixation. Further, roots are important for storing carbohydrates that are needed for regrowth in spring and after each harvest. Previous selection for a g... | 10.1186/s13007-021-00825-3 | 34,876,178 | Plant methods | 2,021 | ||
Association between dental caries and molar-incisor hypomineralisation in first permanent molars: A hierarchical model. | OBJECTIVE
To assess whether the prevalence of dental caries is associated with the presence of molar-incisor hypomineralisation (MIH) in first permanent molars (FPMs).
METHODS
A cross-sectional study was conducted with a sample of 5368 FPMs from 1342 children aged 8-10 years from Florianopolis, Brazil. Dental caries ... | 10.1111/cdoe.12778 | 35,879,857 | D002648:Child; D006801:Humans; D003731:Dental Caries; D003744:Dental Enamel Hypoplasia; D003430:Cross-Sectional Studies; D000094604:Molar Hypomineralization; D008963:Molar; D015995:Prevalence | Community dentistry and oral epidemiology | 2,023 | |
A molecular epidemiological analysis of tuberculosis trends in South Korea. | Molecular epidemiological data are needed to assess tuberculosis (TB)-management policy outcomes in South Korea. IS6110 restriction fragment-length polymorphism (IS6110-RFLP) and mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) analyses are major molecular epidemiological tools for i... | 10.1016/j.tube.2018.06.003 | 30,029,897 | D000328:Adult; D017677:Age Distribution; D004269:DNA, Bacterial; D005260:Female; D005838:Genotype; D006801:Humans; D020071:Interspersed Repetitive Sequences; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis; D010641:Phenotype; D012150:P... | Tuberculosis (Edinburgh, Scotland) | 2,018 | D004269:DNA, Bacterial |
Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model. | Regulatory agencies currently recommend itraconazole (ITZ) as a strong cytochrome P450 3A (CYP3A) inhibitor for clinical drug-drug interaction (DDI) studies. This work by an International Consortium for Innovation and Quality in Pharmaceutical Development working group (WG) is to develop and verify a mechanistic ITZ ph... | 10.1002/psp4.12449 | 31,215,774 | D019540:Area Under Curve; D051544:Cytochrome P-450 CYP3A; D054796:Drug Dosage Calculations; D004347:Drug Interactions; D018565:Food-Drug Interactions; D006801:Humans; D017964:Itraconazole; D015233:Models, Statistical | CPT: pharmacometrics & systems pharmacology | 2,019 | D017964:Itraconazole; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A |
Effects of Orthoses on Standing Postural Control and Muscle Activity in Children With Cerebral Palsy. | PURPOSE
This exploratory study assessed postural control and muscle activity in children with cerebral palsy while standing barefoot (BF), in prescribed ankle-foot orthoses (AFOs) and in distal control orthoses (DCOs), which stabilized foot-ankle and deliberately aligned the shank.
METHODS
This within-subject study e... | 10.1097/PEP.0000000000000802 | 34,107,523 | D000842:Ankle; D002547:Cerebral Palsy; D002648:Child; D061826:Foot Orthoses; D006801:Humans; D009132:Muscles; D004856:Postural Balance | Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association | 2,021 | |
Prognostic significance of soluble interleukin-2 receptor levels in patients with dilated cardiomyopathy. | BACKGROUND
Activation of T lymphocytes is thought to mediate myocardial dysfunction in dilated cardiomyopathy (CMP), probably through cytotoxic cytokines, but its value as a prognostic factor has not been evaluated.
METHODS
For 2 years we prospectively followed 76 patients (65 males, 11 females, age 49 +/- 7 years) w... | 10.1046/j.1365-2362.2003.01111.x | 12,795,639 | D002311:Cardiomyopathy, Dilated; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015375:Receptors, Interleukin-2; D012720:Severity of Illness Index; D012995:Solubility; D013601:T-Lymphocytes | European journal of clinical investigation | 2,003 | D015375:Receptors, Interleukin-2 |
Engineering pre-vascularized bone-like tissue from human mesenchymal stem cells through simulating endochondral ossification. | Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems, so the vascularization depends on post-implantation angiogenesis from the host, which is often insufficient for repairing large bone defects. In this study, we aimed to create pre-vascularized bone-like tissue from human bone m... | 10.1016/j.biomaterials.2022.121451 | 35,259,584 | D000818:Animals; D001842:Bone and Bones; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D059630:Mesenchymal Stem Cells; D051379:Mice; D018919:Neovascularization, Physiologic; D010012:Osteogenesis; D023822:Tissue Engineering; D054457:Tissue Scaffolds | Biomaterials | 2,022 | |
Nonadditive effects of floral display and spur length on reproductive success in a deceptive orchid. | Pollinators may mediate selection on traits affecting pollinator attraction and effectiveness, and while nonadditive effects of traits influencing the two components of pollination success are expected when seed production is pollen limited, they have been little studied. In a factorial design, we manipulated one putat... | 10.1890/11-0791.1 | 22,352,154 | D000818:Animals; D035264:Flowers; D029595:Orchidaceae; D054817:Pollination; D012641:Selection, Genetic | Ecology | 2,011 | |
Oil mobility in a saturated water-wetted bed of glass beads. | The mobilization of an oil bank in a packed bed of glass beads saturated with an aqueous phase has been studied both theoretically and experimentally. The size of the glass beads was varied in the range between 0.5 and 5mm. Two oils (hexadecane and hexane) with viscosities different for an order of magnitude and densit... | 10.1016/s0304-3894(02)00281-9 | 12,573,846 | D005898:Glass; D008962:Models, Theoretical; D009821:Oils; D010316:Particle Size; D016062:Porosity; D012989:Soil Pollutants; D014783:Viscosity; D014872:Water Movements | Journal of hazardous materials | 2,003 | D009821:Oils; D012989:Soil Pollutants |
Quality of life, psychological wellbeing and resilience: a survey on the Italian population living in a new lodging after the earthquake of April 2009. | OBJECTIVE
The aim of this study is to estimate the quality of life and the psychological wellbeing as a result of the earthquake which occurred the 6th of April 2009 and that struck the population of the city of L'Aquila.
METHODS
A random sample of 281 subjects, from the population that had the possibility of living ... | 10.7416/ai.2014.1957 | 24,452,183 | D000293:Adolescent; D000328:Adult; D055866:Earthquakes; D005260:Female; D006304:Health Status; D006798:Housing; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D055500:Resilience, Psychological; D011795:Surveys and Questionnaires; D055815:Young Adult | Annali di igiene : medicina preventiva e di comunita | 2,014 | |
Investigating thiol-modification on hyaluronan via carbodiimide chemistry using response surface methodology. | Hyaluronan (HA) is a naturally occurring glycosaminoglycan widely researched for its use as a biomaterial in tissue engineering, drug delivery, angiogenesis, and ophthalmic surgeries. The mechanical properties of this biomaterial can be altered to a required extent by chemically modifying the pendant reactive groups. H... | 10.1002/jbm.a.35366 | 25,369,214 | D000577:Amides; D002234:Carbodiimides; D006820:Hyaluronic Acid; D013438:Sulfhydryl Compounds; D013499:Surface Properties | Journal of biomedical materials research. Part A | 2,015 | D000577:Amides; D002234:Carbodiimides; D013438:Sulfhydryl Compounds; D006820:Hyaluronic Acid |
Treatment and surveillance of advanced, metastatic iodine-resistant differentiated thyroid cancer. | PURPOSE OF REVIEW
This review will focus on the management and treatment of metastatic thyroid cancer that is radioactive iodine refractory and review the new drugs and their mechanism of actions as well as their adverse events.
RECENT FINDINGS
Until recently, there were no efficacious therapeutic modalities for thes... | 10.1097/CCO.0000000000000349 | 28,141,684 | D000970:Antineoplastic Agents; D002454:Cell Differentiation; D006801:Humans; D007457:Iodine Radioisotopes; D011836:Radiation Tolerance; D013964:Thyroid Neoplasms | Current opinion in oncology | 2,017 | D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes |
Genetic diversity of Fusarium pseudocircinatum in the central western region of Mexico: the case of big-leaf mahogany malformation disease. | Fusarium pseudocircinatum is the main causal agent of big-leaf mahogany malformation disease (BLMMD) of mahogany (Swietenia macrophylla) in Mexico. Although, BLMMD is the most important disease for this high-value timber species, there is a lack of information on the genetic variation present in geographically diverse ... | 10.1007/s11033-020-05711-0 | 32,772,344 | D004777:Environment; D005670:Fusarium; D049770:Genes, Mating Type, Fungal; D014644:Genetic Variation; D005838:Genotype; D029582:Meliaceae; D008800:Mexico; D018895:Microsatellite Repeats; D010802:Phylogeny; D010935:Plant Diseases; D018515:Plant Leaves | Molecular biology reports | 2,020 | |
The prevalence of methicillin-resistant staphylococcus aureus among the residents of six nursing homes for the elderly. | Admissions to Irish hospitals from nursing homes are recognized as a high-risk category for methicillin-resistant Staphylococcus aureus (MRSA) colonization. This study was conducted between August 1994 and May 1995 to determine the prevalence of MRSA within six Eastern Health Board elderly care nursing homes. A point p... | 10.1053/jhin.2000.0758 | 10,973,751 | D000368:Aged; D000369:Aged, 80 and over; D001434:Bacteriophage Typing; D003428:Cross Infection; D005260:Female; D006707:Homes for the Aged; D006801:Humans; D007494:Ireland; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009735:Nursing Homes; D015995:Prevalence; D013203:Staphylococcal Infections; D0... | The Journal of hospital infection | 2,000 | |
Phorbol ester induced short- and long-term permeabilization of the blood-CSF barrier in vitro. | Interconnected by tight junctions, the epithelial cells of the choroid plexus form a barrier separating the cerebrospinal fluid (CSF) from blood. Using an in vitro model based on porcine choroid plexus epithelial cells (PCPEC), we investigated the influence of PKC activating phorbol 12-myristate 13-acetate (PMA) on bar... | 10.1016/j.brainres.2005.09.058 | 16,271,356 | D000818:Animals; D001812:Blood-Brain Barrier; D002273:Carcinogens; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid; D002831:Choroid Plexus; D003599:Cytoskeleton; D017097:Electric Impedance; D004847:Epithelial Cells; D066298:In Vitro Techniques; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9... | Brain research | 2,005 | D002273:Carcinogens; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D013755:Tetradecanoylphorbol Acetate |
Effects of organic and aqueous solvents on the electronic absorption and fluorescence of chloroaluminum (III) tetrasulphonated naphthalocyanine. | The effects of various solvents on the ground and excited states of chloroaluminum (III) tetrasulphonated naphthalocyanine (AlNcS(4)) were studied. Both the absorbance and fluorescence spectra were found to be influenced by the hydrogen bond donating ability of various solvents. As the hydrogen bond donating ability of... | 18,967,536 | Talanta | 1,999 | |||
Cutaneous tumoural melanosis: a presentation of complete regression of cutaneous melanoma. | Partial regression is common in cutaneous melanoma; however, complete regression manifesting as tumoural melanosis is rare, conceptually challenging and under-reported. In this study we report on clinical, histological and molecular findings in four cases of completely regressed cutaneous melanoma with nodal or brain m... | 10.1016/j.pathol.2019.01.008 | 31,023,480 | D000368:Aged; D001921:Brain; D005260:Female; D020558:GTP Phosphohydrolases; D006801:Humans; D008198:Lymph Nodes; D008297:Male; D008545:Melanoma; D008548:Melanosis; D008565:Membrane Proteins; D008875:Middle Aged; D009154:Mutation; D009362:Neoplasm Metastasis; D048493:Proto-Oncogene Proteins B-raf; D012878:Skin Neoplasms... | Pathology | 2,019 | D008565:Membrane Proteins; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human |
Syntactic Versus Memory Accounts of the Sentence Comprehension Deficits of Specific Language Impairment: Looking Back, Looking Ahead. | Purpose
Compared with same-age typically developing peers, school-age children with specific language impairment (SLI) exhibit significant deficits in spoken sentence comprehension. They also demonstrate a range of memory limitations. Whether these 2 deficit areas are related is unclear. The present review article aims... | 10.1044/2016_JSLHR-L-15-0325 | 27,973,643 | D002648:Child; D032882:Comprehension; D006801:Humans; D007805:Language Development Disorders; D008568:Memory; D008960:Models, Psychological; D050765:Qa-SNARE Proteins | Journal of speech, language, and hearing research : JSLHR | 2,016 | D050765:Qa-SNARE Proteins |
The Regular Interaction Pattern among Odorants of the Same Type and Its Application in Odor Intensity Assessment. | The olfactory evaluation function (e.g., odor intensity rating) of e-nose is always one of the most challenging issues in researches about odor pollution monitoring. But odor is normally produced by a set of stimuli, and odor interactions among constituents significantly influenced their mixture's odor intensity. This ... | 10.3390/s17071624 | 28,703,760 | D000447:Aldehydes; D000465:Algorithms; D009666:Nose; D009812:Odorants; D012903:Smell | Sensors (Basel, Switzerland) | 2,017 | D000447:Aldehydes |
Precise editing of CLAVATA genes in Brassica napus L. regulates multilocular silique development. | Multilocular silique is a desirable agricultural trait with great potential for the development of high-yield varieties of Brassica. To date, no spontaneous or induced multilocular mutants have been reported in Brassica napus, which likely reflects its allotetraploid nature and the extremely low probability of the simu... | 10.1111/pbi.12872 | 29,250,878 | D029688:Brassica napus; D055786:Gene Knockout Techniques; D017343:Genes, Plant; D010940:Plant Proteins; D019655:Quantitative Trait, Heritable; D012639:Seeds | Plant biotechnology journal | 2,018 | D010940:Plant Proteins |
Prevalence of chest wall deformities in a large sample of Iranian children aged 7-14 years. | OBJECTIVE
Pectus excavatum (PE) and pectus carinatum (PC) are two common chest deformities. We investigated the prevalence of chest wall deformities including PE and PC in Iranian population.
METHODS
25587 children and adolescents aged 7-14 years consisting of 13586 (53.1%) males and 12001 (46.9%) females were studie... | 23,056,708 | Iranian journal of pediatrics | 2,010 | |||
Multicomponent type II anion relay chemistry (ARC): one-pot syntheses of 2,3-disubstituted furans and thiophenes. | Effective, one-pot syntheses of 2,3-disubstituted furans and thiophenes, exploiting 2-tert-butyldimethylsilyl-3-formylfuran and -thiophene as the respective bifunctional linchpins, have been developed. The synthetic protocol involves multicomponent type II Anion Relay Chemistry (ARC) mediated by a solvent-controlled C(... | 10.1021/ol900434k | 19,301,924 | D000838:Anions; D020650:Combinatorial Chemistry Techniques; D005663:Furans; D008094:Lithium; D015394:Molecular Structure; D009942:Organometallic Compounds; D013876:Thiophenes | Organic letters | 2,009 | D000838:Anions; D005663:Furans; D009942:Organometallic Compounds; D013876:Thiophenes; D008094:Lithium |
Purification and characterization of a novel vascular endothelial cell growth inhibitor secreted by macrophage-like U-937 cells. | A human histiocytic lymphoma cell line, U-937 cells, secretes several vascular endothelial cell growth inhibitors including leukemia inhibitory factor, oncostatin M, tumor necrosis factor-alpha, and transforming growth factor-beta1. Characterization of partially purified fractions from the conditioned media of phorbol ... | 10.1093/oxfordjournals.jbchem.a022296 | 9,990,136 | D000818:Animals; D002417:Cattle; D004730:Endothelium, Vascular; D006131:Growth Inhibitors; D006801:Humans; D008264:Macrophages; D018919:Neovascularization, Physiologic; D017421:Sequence Analysis; D013755:Tetradecanoylphorbol Acetate; D020298:U937 Cells | Journal of biochemistry | 1,999 | D006131:Growth Inhibitors; D013755:Tetradecanoylphorbol Acetate |
Omitting axilla lymphadenectomy even by positive sentinel lymph node: a change in breast cancer treatment practice. | Sentinel lymph node biopsy (SLNB) has been a reliable technique to accurately predict the axilla node status in women with breast cancer with clinically negative lymph nodes. Based on predictive accuracy evidence from large-scale clinical trials, SLNB has become the current standard of care in breast cancer, preventing... | 10.2217/whe.11.46 | 21,790,334 | Women's health (London, England) | 2,011 | ||
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits in a young woman: A case report. | BACKGROUND
Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a newly recognized rare disease. The renal pathology is characterized by prominent manifestations of membranous hyperplasia, which are easy to misdiagnose. The clinical symptoms are severe. Massive proteinuria and hy... | 10.12998/wjcc.v9.i10.2357 | 33,869,614 | World journal of clinical cases | 2,021 | ||
FGF-2 isoforms of 18 and 22.5 kDa differentially modulate t-PA and PAI-1 expressions on the pancreatic carcinoma cells AR4-2J: consequences on cell spreading and invasion. | Pancreatic tumors overexpress FGF-2 and t-PA, but the implication of the growth factor in t-PA synthesis and t-PA-dependent tumor invasion remains unknown. FGF-2 is present in different isoforms: The 18 kDa FGF-2 is secreted, while the 22.5 kDa one is nuclearized and exerts intracrine regulations bypassing cell-surface... | 10.1002/(sici)1097-0215(20000215)85:4<555::aid-ijc18>3.0.co;2-h | 10,699,930 | D000818:Animals; D002455:Cell Division; D003094:Collagen; D004318:Doxycycline; D004338:Drug Combinations; D005109:Extracellular Matrix; D016222:Fibroblast Growth Factor 2; D015972:Gene Expression Regulation, Neoplastic; D007700:Kinetics; D007797:Laminin; D051379:Mice; D008819:Mice, Nude; D008970:Molecular Weight; D0162... | International journal of cancer | 2,000 | D004338:Drug Combinations; D007797:Laminin; D017395:Plasminogen Activator Inhibitor 1; D020033:Protein Isoforms; D011509:Proteoglycans; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2; C059485:matrigel; D003094:Collagen; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator... |
Effective immunity to dental caries: gastric intubation of Streptococcus mutans whole cells or cell walls induces protective immunity in gnotobiotic rats. | Gnotobiotic rats were given Streptococcus mutans 6715 whole cells (WC), purified cell walls (CW), or cell wall lysate by gastric intubation (GI), and assessments were made of humoral immune responses in serum and saliva and of caries protection. Levels of secretory immunoglobulin A (IgA) and IgG antibodies to S. mutans... | 10.1128/iai.39.2.645-654.1983 | 6,832,813 | D000818:Animals; D000907:Antibodies, Bacterial; D000918:Antibody Specificity; D002473:Cell Wall; D003731:Dental Caries; D005856:Germ-Free Life; D007114:Immunization; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007441:Intubation, Gastrointestinal; D051381:Rats;... | Infection and immunity | 1,983 | D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins |
[Metachronous Bilateral Hemothorax Due to Reverse Chance Type Thoracic Fracture]. | Metachronous bilateral hemothorax due to reverse Chance type thoracic fracture is very rare. In this case, we experienced a case of metachronous bilateral hemothorax, triggered by a thoracic fracture in which the anterior component of the spine collapsed, so-called reverse Chance type thoracic fracture. An 83-year-old ... | 28,595,220 | D000063:Accidents, Traffic; D000369:Aged, 80 and over; D004322:Drainage; D005260:Female; D050723:Fractures, Bone; D006491:Hemothorax; D006801:Humans; D013896:Thoracic Diseases; D014057:Tomography, X-Ray Computed | Kyobu geka. The Japanese journal of thoracic surgery | 2,017 | ||
Pre-screening workers to overcome bias amplification in online labour markets. | Groups have access to more diverse information and typically outperform individuals on problem solving tasks. Crowdsolving utilises this principle to generate novel and/or superior solutions to intellective tasks by pooling the inputs from a distributed online crowd. However, it is unclear whether this particular insta... | 10.1371/journal.pone.0249051 | 33,755,712 | D000328:Adult; D015982:Bias; D063045:Crowdsourcing; D005260:Female; D006801:Humans; D007586:Job Application; D007600:Judgment; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving; D011795:Surveys and Questionnaires | PloS one | 2,021 | |
Implementation of individually tailored treatment plans in a group-based intervention for women with mixed vulvo-vaginal and sexual health concerns following cancer treatment: A feasibility study. | PURPOSE
This study evaluated a professionally-led, group-based vulvo-vaginal and sexual health (VSH) workshop for women diagnosed with cancer. The study goals were to: (1) implement and assess a novel group intervention for diverse VSH concerns; (2) explore post-workshop changes in symptom bother, motivation to use VSH... | 10.1016/j.ejon.2022.102236 | 36,827,834 | D006801:Humans; D005260:Female; D055815:Young Adult; D000328:Adult; D008875:Middle Aged; D000368:Aged; D000369:Aged, 80 and over; D000074384:Sexual Health; D005240:Feasibility Studies; D012725:Sexual Behavior; D009369:Neoplasms; D011795:Surveys and Questionnaires | European journal of oncology nursing : the official journal of European Oncology Nursing Society | 2,023 | |
Outcome after femoral neck fractures: a comparison of Harris Hip Score, Eq-5d and Barthel Index. | INTRODUCTION
The objective of this study was to evaluate the discriminatory ability and responsiveness of the Harris Hips Score, the Barthel Index and the Eq-5d (Euroqol) in an unselected population of patients with displaced femoral neck fracture.
METHODS
Data were collected at 4 and 12 months after surgery from a p... | 10.1016/j.injury.2008.03.027 | 18,656,868 | D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D004812:Epidemiologic Methods; D005260:Female; D005265:Femoral Neck Fractures; D005593:Fracture Fixation, Internal; D006305:Health Status Indicators; D006621:Hip Joint; D006801:Humans; D008297:Male; D008... | Injury | 2,008 | |
Transepithelial transport of Cerulenin across Caco-2 cell monolayers. | The transepithelial transport of Cerulenin across Caco-2 cell monolayers was examined in this study. The permeated amounts of Cerulenin were measured by HPLC method to calculate the permeation rate and the apparent permeability coefficient (P(app)). The transport of Cerulenin was independent on apical pH and exhibited ... | 10.1007/BF03191153 | 19,645,214 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001692:Biological Transport; D018938:Caco-2 Cells; D002569:Cerulenin; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D054872:Fatty Acid Synthesis Inhibitors; D006801:Humans; D007408:Intestinal A... | European journal of drug metabolism and pharmacokinetics | 2,009 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D054872:Fatty Acid Synthesis Inhibitors; D002569:Cerulenin |
Infant and young child feeding indicators across nine East and Southeast Asian countries: an analysis of National Survey Data 2000-2005. | OBJECTIVE
To compare infant and young child feeding practices in children aged 0-23 months across nine East and Southeast Asian countries.
DESIGN
Secondary analyses of cross-sectional data from available Demographic and Health Surveys (DHS; Indonesia, Philippines, Timor-Leste, Cambodia and Vietnam), Multiple Indicato... | 10.1017/S1368980010000844 | 20,441,662 | D001210:Asia, Southeastern; D001903:Bottle Feeding; D001942:Breast Feeding; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005202:Asia, Eastern; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D00723... | Public health nutrition | 2,010 | |
Assessment of IcareONE rebound tonometer for self-measuring intraocular pressure. | PURPOSE
To evaluate the precision of the IcareONE rebound tonometer, which was developed for self-measuring intraocular pressure (IOP) and to compare IcareONE measurement with Goldmann applanation tonometry (GAT).
METHODS
Twenty-four healthy eyes and 81 glaucomatous eyes were enrolled. IOP measurements (three times p... | 10.1111/aos.12108 | 23,586,927 | D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension; D011446:Prospective Studies; D015203:Reproducibility of Resul... | Acta ophthalmologica | 2,014 | |
[Patients suffered from enlarged vestibular aqueduct syndrome in Chifeng deaf and dumb school detected by Pendred's syndrome gene hot spot mutation screening]. | OBJECTIVE
To investigate the incidence of hot spot mutation of PDS gene by genetic screening testing method in Chifeng City, Inner Mongolia. The feasibility and effectiveness of genetic screening method in finding enlarged vestibular aqueduct syndrome were confirmed by temporal bone CT scan.
METHODS
DNA were extracte... | 17,007,371 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005820:Genetic Testing; D034381:Hearing Loss; D006801:Humans; D026901:Membrane Transport Proteins; D017354:Point Mutation; D000076988:Sulfate Transporters; D013577:Syndrome; D014723:Vestibular Aqueduct; D015837:Vestibular Disea... | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | 2,006 | D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters | |
Noninvasive high-frequency oscillatory ventilation as respiratory support in preterm infants: a meta-analysis of randomized controlled trials. | BACKGROUND
Noninvasive high-frequency oscillatory ventilation (nHFOV), a relatively new modality, is gaining popularity despite scarce evidence. This meta-analysis was designed to evaluate the efficacy and safety of nHFOV as respiratory support in premature infants.
METHODS
We searched MEDLINE, EMBASE, CINAHL, and Co... | 10.1186/s12931-019-1023-0 | 30,876,411 | D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D063087:Noninvasive Ventilation; D016032:Randomized Controlled Trials as Topic; D012127:Respiratory Distress Syndrome, Newborn | Respiratory research | 2,019 | |
Parallel Prefetching for Canonical Ensemble Monte Carlo Simulations. | In order to enable large-scale molecular simulations, algorithms must efficiently utilize multicore processors that continue to increase in total core count over time with relatively stagnant clock speeds. Although parallelized molecular dynamics (MD) software has taken advantage of this trend in computer hardware, sin... | 10.1021/acs.jpca.0c05242 | 32,841,030 | The journal of physical chemistry. A | 2,020 | ||
Diagnosis of small round cell tumors of childhood. | Primitive tumors, especially in children, can be extremely difficult to diagnose by conventional means. A wide variety of new methods have appeared in biomedical research that are applicable to diagnosis. These include (but are not limited to) tissue culture, cytogenetics, molecular genetics, and immunophenotypic analy... | 3,285,915 | D000911:Antibodies, Monoclonal; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007158:Immunologic Techniques; D009447:Neuroblastoma; D010524:Peripheral Nervous System Neoplasms; D012208:Rhabdomyosarcoma; D012512:Sarcoma, Ewing; D014407:Tumor Cells, Cultured | Bulletin du cancer | 1,988 | D000911:Antibodies, Monoclonal | |
[Overviews - status quo, potentials and perspectives]. | The increase in scientific literature has led reviewers to conduct overviews, hereby creating a new publication type. Overviews of reviews may have several advantages. For example, they can be conducted in a shorter time frame, they offer the opportunity of providing decision makers with a broader summary of the eviden... | 24,315,329 | D019317:Evidence-Based Medicine; D005858:Germany; D006801:Humans; D015201:Meta-Analysis as Topic; D011643:Publishing; D012107:Research Design; D012196:Review Literature as Topic | Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen | 2,013 | ||
Can computed tomography--assisted virtual endoscopy be an innovative tool for detecting urethral tissue pathologies? | OBJECTIVE
To test if virtual endoscopy (VE) enabled by 3-dimensional computed tomographic (CT) scanner with supporting software allows for practical clinical interrogation and evaluation of the urethral lumen and anatomy in an animal model.
METHODS
Assessment of urethral anatomy and repair results was performed in 18... | 24,485,996 | D000818:Animals; D003558:Cystoscopy; D004285:Dogs; D004724:Endoscopy; D021621:Imaging, Three-Dimensional; D008297:Male; D023421:Models, Animal; D012984:Software; D014057:Tomography, X-Ray Computed; D014521:Urethra; D014522:Urethral Diseases; D014525:Urethral Stricture; D001743:Urinary Bladder; D014554:Urination | Urology | 2,014 | ||
Power wheelchair range testing and energy consumption during fatigue testing. | The range of a power wheelchair depends on many factors including: battery type, battery state, wheelchair/rider weight, terrain, the efficiency of the drive train, and driving behavior. The purpose of this study was to evaluate the feasibility of three methods of estimating power wheelchair range. Another significant ... | 8,592,297 | D011211:Electric Power Supplies; D013314:Stress, Mechanical; D014910:Wheelchairs | Journal of rehabilitation research and development | 1,995 | ||
Unreadiness for hospital discharge predicts readmission among cardiac patients: results from the national DenHeart survey. | AIMS
Readiness for hospital discharge describes a patient's perception of feeling prepared to leave the hospital. In mixed patient populations, readiness for hospital discharge has shown to predict readmission and mortality in the short term. The objectives of a population of men and women with cardiac diseases, were t... | 10.1093/eurjcn/zvab017 | 33,713,110 | D000359:Aftercare; D003430:Cross-Sectional Studies; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D010351:Patient Discharge; D010359:Patient Readmission | European journal of cardiovascular nursing | 2,021 | |
[Sintering prophylaxis of a vertebral body replacement: anterior cement augmentation of vertebral end plates]. | Due to the increasing number of elderly patients with osteoporosis, the incidence of more complex operations demanding a vertebral body replacement is increasing in this population. Cement augmentation of pedicle screws helps to prevent screw pullout. Similarly it is possible to augment the end plates in anterior spine... | 10.1007/s00132-010-1604-6 | 20,607,473 | D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements; D001863:Bone Screws; D004867:Equipment Design; D005593:Fracture Fixation, Internal; D006358:Hot Temperature; D006801:Humans; D015990:Placebo Effect; D012086:Reoperation; D016103:Spinal Fractures; D013123:Spinal Fusion; D016896:Treatment Outcome; D054854:Ver... | Der Orthopade | 2,010 | D001843:Bone Cements |
Purification and characterization of an (ADP-ribose)n glycohydrolase from human erythrocytes. | An (ADP-ribose)n glycohydrolase from human erythrocytes was purified approximately 13,000-fold and characterized. On sodium dodecyl sulfate/polyacrylamide gel the purified enzyme appeared homogeneous and had an estimated relative molecular mass (Mr) of 59,000. Amino acid analysis showed that the enzyme had a relatively... | 10.1111/j.1432-1033.1990.tb19093.x | 2,379,504 | D000246:Adenosine Diphosphate Ribose; D000596:Amino Acids; D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes; D006026:Glycoside Hydrolases; D006168:Guinea Pigs; D006657:Histones; D006801:Humans; D008930:Mitochondria, Liver; D009711:Nuc... | European journal of biochemistry | 1,990 | D000596:Amino Acids; D006657:Histones; D009711:Nucleotides; D000246:Adenosine Diphosphate Ribose; D011189:Potassium Chloride; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase |
In vitro evaluation of the strength of the conical implant-to-abutment joint in two commercially available implant systems. | STATEMENT OF PROBLEM
The cone-screw abutment has been shown to diminish micromovement, reducing the burden of component loosening and fracture. However, it is unclear whether the conical taper and joint design influence strength of the interface, with respect to unfavorable bending moments.
PURPOSE
This comparative s... | 10.1016/s0022-3913(00)70016-3 | 10,793,390 | D000044:Dental Abutments; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019232:Dental Restoration Failure; D003799:Dental Stress Analysis; D004548:Elasticity; D019544:Equipment Failure Analysis; D006801:Humans; D018583:Pliability; D018709:Statistics, Nonparametric | The Journal of prosthetic dentistry | 2,000 | D015921:Dental Implants |
Time lag of glucose from intravascular to interstitial compartment in humans. | The accuracy of continuous interstitial fluid (ISF) glucose sensing is an essential component of current and emerging open- and closed-loop systems for type 1 diabetes. An important determinant of sensor accuracy is the physiological time lag of glucose transport from the vascular to the interstitial space. We performe... | 10.2337/db13-1132 | 24,009,261 | D000328:Adult; D001692:Biological Transport; D001786:Blood Glucose; D005260:Female; D005947:Glucose; D006801:Humans; D008297:Male; D017551:Microdialysis; D008875:Middle Aged | Diabetes | 2,013 | D001786:Blood Glucose; D005947:Glucose |
Humanization in healthcare arises from the need for a holistic approach to illness. | Suffering is not only exclusive to patients or their relatives, but also to the health professionals, who feel to be at the center of the depersonalization process. Over-technification and the fact that the disease process is sometimes the only focal point of our activities, together with the ever-increasing influence ... | 10.1016/j.medin.2017.08.002 | 29,132,912 | D000359:Aftercare; D001291:Attitude of Health Personnel; D002055:Burnout, Professional; D003142:Communication; D003159:Community-Institutional Relations; D003219:Confidentiality; D004645:Empathy; D006694:Holistic Health; D006801:Humans; D007362:Intensive Care Units; D009042:Motivation; D009147:Music Therapy; D010361:Pa... | Medicina intensiva | 2,018 | |
[Clinical analysis of liver transplantation in end-stage autoimmune liver diseases]. | OBJECTIVE
To explore the clinical characteristics and long-term prognosis of recipients with end-stage autoimmune liver diseases (AILD) after liver transplantation.
METHODS
A retrospective study was conducted. The data of 147 end-stage autoimmune liver diseases recipients who underwent liver transplantation admitted ... | 10.3760/cma.j.issn.2095-4352.2019.11.017 | 31,898,573 | D000328:Adult; D058625:End Stage Liver Disease; D005260:Female; D019693:Hepatitis, Autoimmune; D006801:Humans; D008107:Liver Diseases; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies | Zhonghua wei zhong bing ji jiu yi xue | 2,019 | |
Risk Factors and Clinical Impacts of Post-Pancreatectomy Acute Pancreatitis After Pancreaticoduodenectomy: A Single-Center Retrospective Analysis of 298 Patients Based on the ISGPS Definition and Grading System. | Background
The definition and grading system of post-pancreatectomy acute pancreatitis (PPAP) has recently been proposed by ISGPS. This study aimed to put this definition and classification into practice and investigate the potential risk factors and clinical impacts of PPAP.
Methods
Demographic and perioperative dat... | 10.3389/fsurg.2022.916486 | 35,860,201 | Frontiers in surgery | 2,022 | ||
Impact of Depression Severity on Patient-Reported Outcome Measures Following Multilevel Anterior Cervical Discectomy and Fusion. | BACKGROUND
Few studies have investigated the effects of preoperative depression and multilevel procedures on patient-reported outcomes (PROs) following anterior cervical discectomy and fusion (ACDF). This study aims to determine the impact of preoperative depression on PROs in single vs multilevel ACDF procedures.
ME... | 10.14444/8180 | 35,177,533 | International journal of spine surgery | 2,022 | ||
POD-Galerkin FSI Analysis for Flapping Motion. | FSI simulations of flapping motions have been widely investigated to develop a flapping-wing micro air vehicle. Because an intensive parametric study is important for the product design, a computationally efficient model is required. The purpose of the present study was to develop a reduced-order model of flapping moti... | 10.3390/biomimetics8070523 | 37,999,164 | Biomimetics (Basel, Switzerland) | 2,023 | ||
Corneal transplantation in aniridia-related keratopathy with a two-year follow-up period, an uncommon disease with precarious course. | PURPOSE
The purpose of this study is to study the frequency, surgical transplantation technique and outcome in patients with aniridia-related keratopathy (ARK) with two-year follow-up period.
METHODS
A retrospective registry-study including all ARK cases performed in Sweden and Denmark between 2001 and 2016 and regis... | 10.1111/aos.15229 | 35,945,658 | D006801:Humans; D003316:Corneal Diseases; D003315:Cornea; D005500:Follow-Up Studies; D012189:Retrospective Studies; D019736:Prostheses and Implants; D016039:Corneal Transplantation; D015948:Keratoplasty, Penetrating; D015783:Aniridia; D014786:Vision Disorders | Acta ophthalmologica | 2,023 | |
Bow-and-arrow sign on point-of-care ultrasound for diagnosis of pacemaker lead-induced heart perforation: A case report and literature review. | BACKGROUND
Pacemaker lead-induced heart perforation is a rare but life-threatening complication of pacemaker implantation, and timely diagnosis remains a challenge for clinicians. Here, we report a case of pacemaker lead-induced cardiac perforation rapidly diagnosed by a "bow-and-arrow" sign on point-of-care ultrasound... | 10.12998/wjcc.v11.i7.1615 | 36,926,400 | World journal of clinical cases | 2,023 | ||
Systematic review of general practice end-of-life symptom control. | BACKGROUND
End of life care (EoLC) is a fundamental role of general practice, which will become more important as the population ages. It is essential that general practice's role and performance of at the end of life is understood in order to maximise the skills of the entire workforce.
OBJECTIVE
To provide a compre... | 10.1136/bmjspcare-2017-001374 | 29,353,252 | D058006:General Practice; D058005:General Practitioners; D006801:Humans; D010819:Physician's Role; D063189:Symptom Assessment; D013727:Terminal Care | BMJ supportive & palliative care | 2,018 | |
Urethral dilatation compared with cystoscopy alone in the treatment of women with recurrent frequency and dysuria. | The relative merits of cystoscopy alone and cystoscopy plus urethral dilatation were compared in a randomised study of women with recurrent frequency and dysuria. One hundred women were studied before and at least 6 months after operation. A detailed questionnaire was completed, the severity of the symptoms was scored ... | 10.1111/j.1464-410x.1988.tb05089.x | 3,401,660 | D000328:Adult; D003558:Cystoscopy; D004106:Dilatation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D012008:Recurrence; D014521:Urethra; D014555:Urination Disorders; D014563:Urodynamics | British journal of urology | 1,988 | |
Brain abnormalities in a case of malonyl-CoA decarboxylase deficiency. | Malonyl-CoA decarboxylase (MCD) deficiency is an extremely rare inborn error of metabolism that presents with metabolic acidosis, hypoglycemia, and/or cardiomyopathy. Patients also show neurological signs and symptoms that have been infrequently reported. We describe a girl with MCD deficiency, whose brain MRI shows wh... | 10.1016/j.ymgme.2005.09.009 | 16,275,149 | D061085:Agenesis of Corpus Callosum; D001921:Brain; D001928:Brain Diseases, Metabolic; D001933:Brain Stem; D002262:Carboxy-Lyases; D002478:Cells, Cultured; D002531:Cerebellum; D002540:Cerebral Cortex; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D004435:Eating; D005260:Female; D005347:Fibroblasts; D006801... | Molecular genetics and metabolism | 2,006 | D002262:Carboxy-Lyases; C021532:malonyl-CoA decarboxylase |
Interaction between endogenous bacterial flora and latent HIV infection. | Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment ... | 10.1128/CVI.00766-12 | 23,616,411 | D017088:AIDS-Related Opportunistic Infections; D001419:Bacteria; D001424:Bacterial Infections; D006678:HIV; D015658:HIV Infections; D006801:Humans; D056265:Microbial Interactions; D064307:Microbiota | Clinical and vaccine immunology : CVI | 2,013 | |
Evaluating the impacts of cannabis legalization: The International Cannabis Policy Study. | An increasing number of jurisdictions have legalized non-medical cannabis use, including Canada in October 2018 and several US states starting in 2012. The policy measures implemented within these regulated markets differ with respect to product standards, labelling and warnings, public education, retail policies, mark... | 10.1016/j.drugpo.2020.102698 | 32,113,149 | The International journal on drug policy | 2,020 | ||
Exercise metaboreflex activation and endothelial function impairment in atrial fibrillation. | Exercising muscle hypoperfusion stimulates afferents (metaboreceptors) involved in the regulation of ventilation. Atrial fibrillation (AF), particularly when combined with diseases causing endothelial (ED) impairment, such as hypertension (HP) and diabetes mellitus (DM), depresses the ED activity and enhances exercise ... | 10.1152/ajpheart.00437.2006 | 16,815,988 | D000368:Aged; D000975:Antioxidants; D001205:Ascorbic Acid; D001281:Atrial Fibrillation; D001916:Brachial Artery; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2; D004311:Double-Blind Method; D004452:Echocardiography; D004554:Electric Countershock; D004730:Endothelium, Vascular; D015444:Exercise; D0052... | American journal of physiology. Heart and circulatory physiology | 2,006 | D000975:Antioxidants; D001205:Ascorbic Acid |
Parsimonious Potential Energy Surface Expansions Using Dictionary Learning with Multipass Greedy Selection. | Potential energy surfaces fit with basis set expansions have been shown to provide accurate representations of electronic energies and have enabled a variety of high-accuracy dynamics, kinetics, and spectroscopy applications. The number of terms in these expansions scales poorly with system size, a drawback that challe... | 10.1021/acs.jpclett.1c02721 | 34,525,799 | The journal of physical chemistry letters | 2,021 | ||
Angiotensin II-induced ET and PGI2 release in rat aortic endothelial cells is mediated by PKC. | Angiotensin II (Ang II) has been shown to stimulate the release of immunoreactive endothelin (ET) from cultured bovine ECs. Also, Ang II activates phospholipase A2 (PLA2) in various tissues, resulting in the release of arachidonic acid and formation of prostaglandins. We used rat aortic endothelial cells to investigate... | 10.1054/plef.1999.0079 | 10,509,866 | D000804:Angiotensin II; D000818:Animals; D001011:Aorta; D002417:Cattle; D016232:Endothelins; D004730:Endothelium, Vascular; D011464:Epoprostenol; D008297:Male; D011493:Protein Kinase C; D051381:Rats | Prostaglandins, leukotrienes, and essential fatty acids | 1,999 | D016232:Endothelins; D000804:Angiotensin II; D011464:Epoprostenol; D011493:Protein Kinase C |
Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. | Breast milk is one possible route of exposure to environmental chemicals, including phenols and chlorinated organic chemicals for breast-fed infants. We developed a highly sensitive method of analyzing breast milk for triclocarban (3,4,4'-trichlorocarbanilide) and eight phenolic compounds: bisphenol A (BPA), 4-tert-oct... | 10.1016/j.jchromb.2005.11.050 | 16,377,264 | D002224:Carbanilides; D005591:Chemical Fractionation; D002851:Chromatography, High Pressure Liquid; D004785:Environmental Pollutants; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D013058:Mass Spectrometry; D008895:Milk, Human; D009862:Online Systems; D010636:Phenols; D012680:Sensitivity and Specif... | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | 2,006 | D002224:Carbanilides; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010636:Phenols; C009540:triclocarban |
[Water birthing: retrospective review of 2625 water births. Contamination of birth pool water and risk of microbial cross-infection]. | UNLABELLED
The aim of this study was to document the practice of 2625 water births at Vipiteno over the period 1997-2009 and compare outcome and safety with normal vaginal delivery. The microbial load of the birth pool water was analyzed, and neonatal infection rates after water birth and after land delivery were compa... | 20,595,945 | D003428:Cross Infection; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D014871:Water Microbiology | Minerva ginecologica | 2,010 | ||
Control of vocal production in budgerigars (Melopsittacus undulatus): selective reinforcement, call differentiation, and stimulus control. | Budgerigars were trained to make a specific call using a real-time automated call recognition system and food reward. Calls produced by the bird were followed by food only if they were similar enough to a template call. The selective reinforcement of a particular call type increased the similarity of the bird's call to... | 10.1016/s0376-6357(97)00041-7 | 24,896,668 | Behavioural processes | 1,997 | ||
The Impact of Polypharmacy on Patient Outcomes in Older Adults With Cancer. | Polypharmacy is prevalent in older adults with cancer and may be advantageous for the management of certain chronic disease states, but uncertainty exists regarding potential hazards and consequences. Cancer-related therapy adds to the prevalence of polypharmacy, which can lead to compromised cancer management plans (i... | 10.1097/PPO.0000000000000277 | 28,731,943 | D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D064420:Drug-Related Side Effects and Adverse Reactions; D015577:Geriatric Assessment; D006801:Humans; D009369:Neoplasms; D017063:Outcome Assessment, Health Care; D019338:Polypharmacy; D011159:Population Surveillance | Cancer journal (Sudbury, Mass.) | 2,017 | |
Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo. | Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulato... | 10.3390/md16040099 | 29,561,805 | D000818:Animals; D037421:Anthozoa; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D051379:Mice; D015394:Molecular Structure; D000067996:RAW 264.7 Cells | Marine drugs | 2,018 | D000893:Anti-Inflammatory Agents; D004224:Diterpenes |
Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons. | We show that the pro-apoptotic proteins Bax and Bak trigger apoptosis when over-expressed in sympathetic neurons cultured in the presence of NGF. This effect can be blocked with z-VAD-fmk, a peptide inhibitor of caspases, but not with anti-apoptotic chemical compounds such as antioxidants or proteasome inhibitors. Thes... | 10.1097/00001756-199801050-00004 | 9,592,040 | D000111:Acetylcysteine; D000590:Amino Acid Chloromethyl Ketones; D000818:Animals; D017209:Apoptosis; D003546:Cysteine Endopeptidases; D015853:Cysteine Proteinase Inhibitors; D003676:Deferoxamine; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009474:Neurons; D010726:Phosphodiesterase Inhibitors; D011518:Pro... | Neuroreport | 1,998 | D000590:Amino Acid Chloromethyl Ketones; C494774:Bak1 protein, rat; C494828:Bax protein, rat; D015853:Cysteine Proteinase Inhibitors; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010726:Phosphodiesterase Inhibitors; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D050998:bcl-2 Ho... |
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. | The sodium channel NaV1.7 has emerged as a promising target for the treatment of pain based on strong genetic validation of its role in nociception. In recent years, a number of aryl and acyl sulfonamides have been reported as potent inhibitors of NaV1.7, with high selectivity over the cardiac isoform NaV1.5. Herein, w... | 10.1021/acs.jmedchem.7b01826 | 29,737,846 | D000595:Amino Acid Sequence; D000818:Animals; D004285:Dogs; D015195:Drug Design; D004355:Drug Stability; D006801:Humans; D007700:Kinetics; D051379:Mice; D008968:Molecular Conformation; D062556:NAV1.7 Voltage-Gated Sodium Channel; D010146:Pain; D051381:Rats; D013449:Sulfonamides; D061567:Voltage-Gated Sodium Channel Blo... | Journal of medicinal chemistry | 2,018 | D062556:NAV1.7 Voltage-Gated Sodium Channel; D013449:Sulfonamides; D061567:Voltage-Gated Sodium Channel Blockers |
Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. | 1. Many studies have shown that hyperhomocysteinaemia is a risk factor for atherosclerotic vascular disease. A mutation (C-677T) in the gene coding for the methylenetetrahydrofolate reductase (MTHFR) enzyme has been shown to produce a thermolabile form of the enzyme. Homozygosity for this mutation has been correlated w... | 9,730,850 | D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography; D003327:Coronary Disease; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008131:London; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D000587:Oxidoreductases Acting on CH-NH Group Dono... | Clinical science (London, England : 1979) | 1,998 | D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2) | |
Reference Intervals of Mitochondrial DNA Copy Number in Peripheral Blood for Chinese Minors and Adults. | BACKGROUND
Mitochondrial DNA (mtDNA) content measured by different techniques cannot be compared between studies, and age- and tissue-related control values are hardly available. In the present study, we aimed to establish the normal reference range of mtDNA copy number in the Chinese population.
METHODS
Two healthy ... | 10.4103/0366-6999.216395 | 29,052,564 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D056915:DNA Copy Number Variations; D004272:DNA, Mitochondrial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008928:M... | Chinese medical journal | 2,017 | D004272:DNA, Mitochondrial |
The remittance advice, auditing for compliance. | Resubmitting claims can be costly in terms of both time and lost revenue. The remittance advice and return to provider reports received by laboratories from carriers/intermediaries are an excellent source for investigating compliance matters. The Department of Health and Human Services, Office of Inspector General, has... | 11,793,526 | D005375:Financial Audit; D019983:Guideline Adherence; D007345:Insurance Claim Review; D007753:Laboratories; D014481:United States; D014483:United States Dept. of Health and Human Services | Clinical leadership & management review : the journal of CLMA | 2,000 | ||
Dramatic Shape Changes Occur as Cytochrome c Folds. | Extensive experimental studies on the folding of cytochrome c (Cyt c) make this small protein an ideal target for atomic detailed simulations for the purposes of quantitatively characterizing the structural transitions and the associated time scales for folding to the native state from an ensemble of unfolded states. W... | 10.1021/acs.jpcb.0c05802 | 32,840,372 | D045304:Cytochromes c; D007700:Kinetics; D017510:Protein Folding; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction | The journal of physical chemistry. B | 2,020 | D045304:Cytochromes c |
The tetrapeptide AcSDKP, an inhibitor of the cell-cycle status for normal human hematopoietic progenitors, has no effect on leukemic cells. | The tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) inhibits the entry into DNA synthesis of murine spleen colony-forming units (CFU-S) and protects these cells during chemotherapy. This synthetic peptide also inhibits the growth of normal human marrow progenitors granulocyte-macrophage colony-forming units (CFU-GM) and... | 1,544,396 | D000328:Adult; D000368:Aged; D002453:Cell Cycle; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA; D004305:Dose-Response Relationship, Drug; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006412:Hematopoietic Stem Cells; D006801:Humans; D007377:Interleukin-3; D007951:Leukemia, Mye... | Experimental hematology | 1,992 | D007377:Interleukin-3; D009842:Oligopeptides; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D004247:DNA; C058504:goralatide | |
Dental eruption in afrotherian mammals. | BACKGROUND
Afrotheria comprises a newly recognized clade of mammals with strong molecular evidence for its monophyly. In contrast, morphological data uniting its diverse constituents, including elephants, sea cows, hyraxes, aardvarks, sengis, tenrecs and golden moles, have been difficult to identify. Here, we suggest r... | 10.1186/1741-7007-6-14 | 18,366,669 | D000818:Animals; D002508:Cephalometry; D048293:Didelphis; D020454:Dugong; D004606:Elephants; D007568:Jaw; D008322:Mammals; D009811:Odontometry; D009929:Organ Size; D014078:Tooth Eruption; D004490:Xenarthra | BMC biology | 2,008 | |
Classification of schizophrenia using feature-based morphometry. | The objective of this study was to use a combined local descriptor, namely scale invariance feature transform (SIFT), and a non linear support vector machine (SVM) technique to automatically classify patients with schizophrenia. The dorsolateral prefrontal cortex (DLPFC), considered a reliable neuroanatomical marker of... | 10.1007/s00702-011-0693-7 | 21,904,897 | D000328:Adult; D001921:Brain; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D012559:Schizophrenia | Journal of neural transmission (Vienna, Austria : 1996) | 2,012 |
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