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Left ventricular function in coronary artery disease. Evaluation of slope of end-systolic pressure-volume line (Emax) and ratio of peak systolic pressure to end-systolic volume (P/Ves). | Left ventricular function was assessed by measurement of systolic pressure-volume variables and ejection fraction in seven normal subjects (group I), five patients with coronary artery disease and normal symmetric left ventricular wall motion (group II) and eight patients with remote myocardial infarction and segmental... | 10.1016/s0735-1097(84)80255-7 | 6,693,649 | D002302:Cardiac Output; D003327:Coronary Disease; D005260:Female; D006321:Heart; D006352:Heart Ventricles; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D010656:Phenylephrine; D011312:Pressure; D013318:Stroke Volume; D013599:Systole | Journal of the American College of Cardiology | 1,984 | D010656:Phenylephrine |
"Whole body" stereotaxy: application of stereotactic endoscopy to operations of herniated lumbar discs. | In order to minimize surgical trauma of operations for lumbar disc prolapses, a modified Laitinen's stereotactic frame was utilized in nine patients. Stereotactic localization of the lesion could be done accurately in all cases. Percutaneous prolapsectomy and nucleotomy was performed successfully in three patients as a... | 10.1007/978-3-7091-6687-1_13 | 1,595,415 | D000328:Adult; D019723:Endoscopes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007405:Intervertebral Disc Displacement; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013238:Stereotaxic Techniques | Acta neurochirurgica. Supplementum | 1,992 | |
Selecting passive and active materials for 1.3 composite power transducers. | 1.3 PZT-polymer composites were fabricated using the dice and fill method with various PZT types and volume fractions. These composites were evaluated for power underwater transducer applications with an air backed and no matching layer configuration. Electrical input and acoustical output powers were monitored as a fu... | 10.1016/s0041-624x(02)00221-4 | 12,160,066 | Ultrasonics | 2,002 | ||
Depression in adolescents with diabetes. | TOPIC
Prevalence and interventions for depression in youth with type 1 diabetes.
PURPOSE
To explore the co-morbidity of youth with diabetes and psychiatric conditions, and evaluate the relationship of youth with co-morbid depression and diabetes on glycemic control, quality of life, family support, behavioral problem... | 10.1111/j.1744-6171.2003.tb00342.x | 12,790,304 | D000293:Adolescent; D000294:Adolescent Behavior; D015928:Cognitive Behavioral Therapy; D003863:Depression; D003922:Diabetes Mellitus, Type 1; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D024802:Nurse's Role; D010353:Patient Education as Topic; D011340:Problem Solving; D012307:Risk Factors; D012... | Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc | 2,003 | D017367:Serotonin Uptake Inhibitors |
Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. | OBJECTIVE
We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS
This was a double-blind, randomized, multicenter, parallel group study of a 24-week treatment w... | 10.2337/dc06-1732 | 17,277,036 | D000218:Adamantane; D000328:Adult; D000368:Aged; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D008297:Male; D008687:Metformin; D008875:Middle Aged; D009570:Nitriles; D011759:Pyrrolidines; D000077597:Vildagliptin | Diabetes care | 2,007 | D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009570:Nitriles; D011759:Pyrrolidines; D008687:Metformin; D000077597:Vildagliptin; D000218:Adamantane |
A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications. | Cyclodextrins (CDs) have brought a revolution in the pharmaceutical field over the last decade. Natural and modified CDs (α-CD and β-CD) have been studied and some have gained US FDA approval or achieved 'Generally Regarded as Safe' (GRAS) status. Another characteristic of CDs is the ease with which they can be induced... | 10.2217/nnm.14.41 | 24,981,652 | D000818:Animals; D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations; D011108:Polymers | Nanomedicine (London, England) | 2,014 | D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations; D011108:Polymers |
Stages of driving behavior change within the Transtheoretical Model (TM). | INTRODUCTION
Many older adults voluntarily restrict their driving or stop driving of their own accord. Driving behavior change may occur in stages, as predicted by the Transtheoretical Model of Behavior Change (TM).
METHOD
This study explored the process of older driver behavior change within the TM framework using i... | 25,142,357 | D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001334:Automobile Driving; D001955:British Columbia; D003657:Decision Making; D004522:Educational Status; D005260:Female; D017144:Focus Groups; D015438:Health Behavior; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008962:Models, Theoreti... | Journal of safety research | 2,014 | ||
Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model. | Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted sub... | 10.3892/or.2015.4281 | 26,397,840 | D000818:Animals; D001854:Bone Marrow Cells; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D004195:Disease Models, Animal; D005347:Fibroblasts; D049452:Green Fluorescent Proteins; D006801:Humans; D051379:Mice; D017154:Stromal Cells; D059016:Tumor Microenvironment; D023041:Xenograft Model Antitumor A... | Oncology reports | 2,015 | D049452:Green Fluorescent Proteins |
Effect of normal and activated human macrophages on Toxoplasma gondii. | Human macrophages derived from in vitro culture of peripheral blood monocytes were studied under a variety of conditions to determine their microbicidal capacity for the obligate intracellular protozoan, Toxoplasma gondii. The effect of macrophages on intracellular Toxoplasma was evaluated morphologically by light and ... | 10.1084/jem.139.5.1154 | 4,132,992 | D000293:Adolescent; D000328:Adult; D000906:Antibodies; D000941:Antigens; D001345:Autoradiography; D002478:Cells, Cultured; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008264:Macrophages; D008297:Male; D008858:Microscopy, Phase-Contrast; D008875:Middle Aged; D009000:Monocytes; D013194:Staining a... | The Journal of experimental medicine | 1,974 | D000906:Antibodies; D000941:Antigens; D014316:Tritium; D013299:Streptodornase and Streptokinase; D013936:Thymidine; D014529:Uridine |
Fibronectin glomerulopathy with monoclonal gammopathy responding to bortezomib plus dexamethasone: a case report. | BACKGROUND
Fibronectin glomerulopathy is a rare, familial glomerular disease characterized by mesangial fibronectin deposition in the glomeruli. It is caused by the genetic defect in fibronectin and does not involve the activation of the immune system. Therefore, glomerular immunoglobulin and complement staining is gen... | 10.1186/s12882-022-03005-0 | 36,451,151 | D005260:Female; D006801:Humans; D000328:Adult; D000069286:Bortezomib; D005353:Fibronectins; D008998:Monoclonal Gammopathy of Undetermined Significance; D007070:Immunoglobulin A; D000911:Antibodies, Monoclonal; D003907:Dexamethasone | BMC nephrology | 2,022 | D000069286:Bortezomib; D005353:Fibronectins; D007070:Immunoglobulin A; D000911:Antibodies, Monoclonal; D003907:Dexamethasone |
Clinical Effect of Ultrasound-Guided Adductor Block on Postoperative Analgesia After Total Knee Replacement. | Objective
To explore the clinical effects of ultrasound-guided adductor block (UGAB) on postoperative analgesia after total knee replacement.
Methods
From March 2022 to June 2022, 60 patients in the First Affiliated Hospital of Chongqing Medical University were included. They were divided into control (n = 30) and ul... | 37,820,664 | Alternative therapies in health and medicine | 2,023 | |||
Steric Constraints Induced Frustrated Growth of Supramolecular Nanorods in Water. | A unique example of supramolecular polymerisation in water based on monomers with nanomolar affinities, which yield rod-like materials with extraordinarily high thermodynamic stability, yet of finite length, is reported. A small library of charge-neutral dendritic peptide amphiphiles was prepared, with a branched nonap... | 10.1002/chem.201503616 | 26,555,139 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,015 | ||
Sodium oxybate for the treatment of fibromyalgia. | INTRODUCTION
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that is synthesized within the CNS, mostly from its parent compound gamma amino butyric acid (GABA). GHB acts as a neuromodulator/neurotransmitter to affect neuronal activity of other neurotransmitters and so, stimulate the release of growth hormone. ... | 10.1517/14656566.2011.589836 | 21,679,091 | D000759:Adjuvants, Anesthesia; D000818:Animals; D017277:Drug Approval; D005356:Fibromyalgia; D006801:Humans; D010146:Pain; D011485:Protein Binding; D018080:Receptors, GABA-B; D012893:Sleep Wake Disorders; D012978:Sodium Oxybate; D014481:United States; D014486:United States Food and Drug Administration | Expert opinion on pharmacotherapy | 2,011 | D000759:Adjuvants, Anesthesia; D018080:Receptors, GABA-B; D012978:Sodium Oxybate |
Return to Work of Cancer Survivors. | Due to improving treatment options, the number of so-called long-term cancer survivors is steadily increasing. Current studies assume that more than 60% of adults survive their cancer. These patients have a variety of problems (chemotherapy-induced neuropathy, fatigue, etc.) that require very special care. In addition ... | 10.1159/000485079 | 29,183,032 | D000328:Adult; D000073116:Cancer Survivors; D006801:Humans; D009369:Neoplasms; D011788:Quality of Life; D062707:Return to Work; D012917:Social Adjustment; D013315:Stress, Psychological | Oncology research and treatment | 2,017 | |
Hirudin versus heparin for use in whole blood in vitro biocompatibility models. | Heparin has traditionally been a widely used anticoagulant in blood research, but has been shown to be inappropriate for work with the complement system because of its complement-interacting properties. In this work, we have compared the effects of heparin with those of the specific thrombin inhibitor hirudin on comple... | 10.1002/jbm.a.32034 | 18,470,919 | D001672:Biocompatible Materials; D001792:Blood Platelets; D002448:Cell Adhesion; D003167:Complement Activation; D015926:Complement C3a; D015938:Complement Membrane Attack Complex; D006493:Heparin; D006629:Hirudins; D006801:Humans; D007962:Leukocytes; D008954:Models, Biological; D009000:Monocytes; D011143:Polyvinyl Chlo... | Journal of biomedical materials research. Part A | 2,009 | D001672:Biocompatible Materials; D015938:Complement Membrane Attack Complex; D006629:Hirudins; D015926:Complement C3a; D011143:Polyvinyl Chloride; D006493:Heparin; D013925:Thromboplastin |
Cholesterol is not synthesized in membranes bearing 3-hydroxy-3-methylglutaryl coenzyme A reductase. | We have shown previously that newly synthesized lanosterol and cholesterol in homogenates of cultured human fibroblasts do not have the same equilibrium buoyant density as the 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in the smooth endoplasmic reticulum (SER) (Lange, Y., and Steck, T. L. (1985) J. Bi... | 3,558,346 | D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol; D004721:Endoplasmic Reticulum; D005347:Fibroblasts; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases; D066298:In Vitro Techniques; D007425:Intracellular Membranes; D007810:Lanosterol; D008099:Liver; D008297:Male; D051381:Rats; D011919:Rats, Inbr... | The Journal of biological chemistry | 1,987 | D007810:Lanosterol; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases | |
Mechanisms of resistance off NSCLC to interferons. | Interferons (IFNs) are naturally occurring cytokines which have pleiotropic actions including regulation of cell growth and differentiation, important for control of tumour growth and development. In this study we investigated the association between the presence of IFN genes in NSCLC cell lines, receptor expression an... | 10.3892/ijo.10.5.933 | 21,533,466 | International journal of oncology | 1,997 | ||
Isolation and characterization of peroxisomes from the liver of normal untreated rats. | The classic method of Leighton et al. [(1968) J. Cell Biol. 37, 482-513] for the isolation of peroxisomes from rat liver involves the use of Triton WR-1339 which alters the biochemical properties of this organelle and requires the specialized type Beaufay-rotor which is not easily available. We have employed Metrizamid... | 10.1111/j.1432-1033.1985.tb08920.x | 3,996,409 | D000818:Animals; D002374:Catalase; D002458:Cell Fractionation; D002499:Centrifugation, Density Gradient; D005260:Female; D005404:Fixatives; D006651:Histocytochemistry; D008099:Liver; D008793:Metrizamide; D008830:Microbodies; D051381:Rats; D011919:Rats, Inbred Strains | European journal of biochemistry | 1,985 | D005404:Fixatives; D002374:Catalase; D008793:Metrizamide |
Clinical interpretation of the flash continuous glucose monitoring data out of range in type 2 diabetes: A real-world study. | AIMS
Flash continuous glucose monitoring system (FCGM) reports nocturnal hypoglycemia with low accuracy in low blood glucose. In our study, we aimed to evaluate the accuracy and clinic profile of FCGM data out of range in T2DM.
METHODS
FCGM data out of range were measured in T2DM patients at eight-time points of a da... | 10.1016/j.diabres.2021.108989 | 34,331,978 | D001786:Blood Glucose; D015190:Blood Glucose Self-Monitoring; D003924:Diabetes Mellitus, Type 2; D006801:Humans; D007003:Hypoglycemia | Diabetes research and clinical practice | 2,021 | D001786:Blood Glucose |
Antrochoanal Polyp and Migrated Dental Implant in the Ipsilateral Maxillary Sinus. | Antrochoanal polyp is usually a benign solitary mass lesion originated from maxillary sinus mucosa and emerging through maxillary ostium. We report a rare case of antrochoanal polyp and migrated dental implant in the ipsilateral maxillary sinus. Clinicians should be aware that ACP may have other concomitant conditions ... | 10.1177/01455613221106205 | 35,634,654 | Ear, nose, & throat journal | 2,022 | ||
Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study. | This case report describes a sudden cardiac death in an apparent healthy 11-month-old infant caused by a multifocal cardiac rhabdomyoma. Parents reported that a few days before the child had fallen to the ground getting a little superficial injury to the scalp. The authors hypothesize that it may have been a transient ... | 10.1186/1746-1596-7-169 | 23,206,573 | D014408:Biomarkers, Tumor; D016757:Death, Sudden, Cardiac; D005260:Female; D006338:Heart Neoplasms; D006352:Heart Ventricles; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D009378:Neoplasms, Multiple Primary; D012207:Rhabdomyoma; D047368:Tumor Burden | Diagnostic pathology | 2,012 | D014408:Biomarkers, Tumor |
Detecting and treating shoulder impingement syndrome: the role of scapulothoracic dyskinesis. | The shoulder joint is most appropriately referred to as the "shoulder complex," since its total range of motion depends on four interworking articulations. The scapula is central in proficient shoulder activity, and rotator cuff muscles will not operate optimally if the scapula is poorly positioned. Dynamic scapular st... | 10.3810/psm.2003.07.431 | 20,086,472 | The Physician and sportsmedicine | 2,003 | ||
Towards the identification of humic ligands associated with iron transport through a salinity gradient. | Humic ligands from boreal rivers have been identified as important sources of iron-binding ligands to the coastal marine environment but remain poorly characterized. A novel method using Fourier transformed infrared spectroscopy (FTIR) was used to identify and quantify iron-binding ligands present in a boreal river in ... | 10.1038/s41598-022-19618-2 | 36,109,552 | D000475:Alkenes; D002244:Carbon; D002264:Carboxylic Acids; D004987:Ethers; D007501:Iron; D008024:Ligands; D018977:Micronutrients; D054712:Salinity; D012623:Seawater | Scientific reports | 2,022 | D000475:Alkenes; D002264:Carboxylic Acids; D004987:Ethers; D008024:Ligands; D018977:Micronutrients; D002244:Carbon; D007501:Iron |
Mesenteric panniculitis: an unusual cause of dyspepsia in a hemodialysis patient. | Many patients with chronic renal failure have dyspeptic symptoms. However, mesenteric panniculitis as a cause of dyspepsia has not been described in this patient group. We report a 78-year-old hemodialysis patient who was admitted because of intractable dyspepsia. Investigations with ultrasonography, endoscopy and bari... | 10.5414/cnp71224 | 19,203,522 | D000368:Aged; D003937:Diagnosis, Differential; D004415:Dyspepsia; D006801:Humans; D007676:Kidney Failure, Chronic; D008297:Male; D015436:Panniculitis, Peritoneal; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed | Clinical nephrology | 2,009 | |
Drinking habits and sickness absence: the contribution of working conditions. | AIMS
The main aim was to examine whether drinking habits including average, binge and problem drinking are associated with self-certified and medically confirmed sickness absence among middle-aged municipal employees. Another aim was to examine whether psychosocial and physical working conditions and work arrangements ... | 10.1177/1403494809350519 | 19,828,773 | D000041:Absenteeism; D000328:Adult; D000428:Alcohol Drinking; D019973:Alcohol-Related Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018582:Sick Leave; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D017132:Workplace | Scandinavian journal of public health | 2,009 | |
Wnt6 induces the specification and epithelialization of F9 embryonal carcinoma cells to primitive endoderm. | Epithelial-to-mesenchymal transitions (EMTs) play key roles in the normal development of an organism as well as its demise following the metastasis of a malignant tumour. An EMT during early mouse development results in the differentiation of primitive endoderm into the parietal endoderm that forms part of the parietal... | 10.1016/j.cellsig.2007.11.001 | 18,160,257 | D021581:Active Transport, Cell Nucleus; D000818:Animals; D019521:Body Patterning; D003994:Bucladesine; D019556:COS Cells; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D017077:Culture Media, Conditioned; D017868:Cyclic AMP-Dependent Protein Kinases; D054278:Embryonal Carcinoma St... | Cellular signalling | 2,008 | C495267:CTNNB1 protein, mouse; D017077:Culture Media, Conditioned; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; C000604429:Snai1 protein, mouse; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D051153:Wnt Proteins; C095936:Wnt6 protein, mouse; D051176:beta Catenin; D014212:Tret... |
Halonium-initiated electrophilic cascades of 1-alkenoylcyclopropane carboxamides: efficient access to dihydrofuropyridinones and 3(2H)-furanones. | Halonium-initiated cascade reaction of 1-alkenoylcyclopropane carboxamides was developed, which leads to the production of dihydrofuropyridinones and 3(2H)-furanones, respectively, depending on the property of substituents on the enone moiety. | 10.1039/c1cc15319f | 22,016,885 | Chemical communications (Cambridge, England) | 2,011 | ||
Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat. | BACKGROUND
The aim of the present study was to evaluate the effect of a moderate diet restriction on the progression of preneoplastic foci into hepatocellular carcinomas (HCCs) and whether such an effect was related to altered cell proliferation, apoptosis, and/or tumour contents of lipid-soluble antioxidants.
METHOD... | 10.1080/003655200750024588 | 10,672,840 | D015073:2-Acetylaminofluorene; D000818:Animals; D000975:Antioxidants; D017209:Apoptosis; D002273:Carcinogens; D002455:Cell Division; D004052:Diethylnitrosamine; D018450:Disease Progression; D002149:Energy Intake; D005982:Glutathione Transferase; D008099:Liver; D008114:Liver Neoplasms, Experimental; D008297:Male; D01008... | Scandinavian journal of gastroenterology | 2,000 | D000975:Antioxidants; D002273:Carcinogens; D014451:Ubiquinone; D014810:Vitamin E; D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene; D005982:Glutathione Transferase |
[Assessing adolescent's health in school medicine: quality of life as a complement to clinical indicators]. | UNLABELLED
Current medical practices of school health for adolescents are more based on the screening of specific physical problems than on psychosocial and subjective aspects of their health.
OBJECTIVES
This study aimed at evaluating the usefulness of a quality of life (QoL) questionnaire during the consultations.
... | 10.1016/j.arcped.2004.07.025 | 15,596,331 | D000293:Adolescent; D003863:Depression; D006304:Health Status; D006801:Humans; D000297:Psychology, Adolescent; D011788:Quality of Life; D012572:School Health Services; D011795:Surveys and Questionnaires | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | 2,004 | |
[Radiotherapy for non-small-cell bronchial cancers: definitions of volumes, patient selection. Recommendations of the International Association for the Study of Lung Cancer (IASLC)]. | Chemoradiation is the standard treatment of unresectable, locally advanced non-small cell lung cancer, with a mean dose of 60-66 Gy, excluding escalation dose schemes. The standard treated volume includes primary tumor, ipsilateral hilar and mediastinal nodes, supraclavicular and contralateral nodes as well, regardless... | 10.1016/s1278-3218(98)80091-7 | 9,868,404 | D002283:Carcinoma, Bronchogenic; D002289:Carcinoma, Non-Small-Cell Lung; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011879:Radiotherapy Dosage; D014057:Tomography, X-... | Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique | 1,998 | |
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity. | Vibrio is a model organism for the study of quorum sensing (QS) signaling and is used to identify QS-interfering drugs. Naturally occurring fimbrolides are important tool compounds known to affect QS in various organisms; however, their cellular targets have so far remained elusive. Here we identify the irreversible fi... | 10.1002/anie.201508052 | 26,609,793 | D001688:Biological Products; D008156:Luciferases; D049449:Luminescence; D014733:Vibrio | Angewandte Chemie (International ed. in English) | 2,016 | D001688:Biological Products; D008156:Luciferases |
Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG. | BACKGROUND
The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.
CASE PRESENTATION
We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and w... | 10.1186/s40164-016-0051-4 | 27,468,365 | Experimental hematology & oncology | 2,015 | ||
CA 125 secretion by peritoneal mesothelial cells. | AIMS
To investigate the secretion of the tumour marker CA 125 by cultured human mesothelial cells; to determine if secretion of CA 125 could be observed by activating the mesothelial monolayers with different cytokines.
METHODS
Mesothelial cells were isolated from human omentum and cultured to confluent monolayers on... | 10.1136/jcp.47.3.263 | 8,163,699 | D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D016207:Cytokines; D004848:Epithelium; D004926:Escherichia coli; D006801:Humans; D007375:Interleukin-1; D008070:Lipopolysaccharides; D008954:Models, Biological; D010538:Peritonitis; D014409:Tumor Necrosis Factor-alpha | Journal of clinical pathology | 1,994 | D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha |
National Institutes of Health Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity. | On 5 and 6 December 2017, the National Institutes of Health (NIH) convened the Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity to identify the status of methods for assessing natural experiments to reduce obesity, areas in which these methods could be improved, and research needs ... | 10.7326/M18-0501 | 29,710,235 | D015982:Bias; D035843:Biomedical Research; D003625:Data Collection; D006291:Health Policy; D006801:Humans; D009316:National Institutes of Health (U.S.); D009765:Obesity; D011159:Population Surveillance; D012107:Research Design; D014481:United States | Annals of internal medicine | 2,018 | |
Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro. | The reduced form of vitamin C, ascorbic acid (AA), has been related with gene expression and cell differentiation in the cerebral cortex. In neurons, AA is mainly oxidized to dehydroascorbic acid (DHA); however, DHA cannot accumulate intracellularly because it induces metabolic changes and cell death. In this context, ... | 10.3390/antiox9121276 | 33,327,638 | Antioxidants (Basel, Switzerland) | 2,020 | ||
Interaction between tumor necrosis factor-alpha and leptin-induced inhibition of cardiac contractile function in isolated ventricular myocytes. | Pro-inflammatory factors such as the adipokine leptin and cytokine tumor necrosis factor-alpha (TNFalpha) have been implicated in the onset of myocardial dysfunction in ischemia-reperfusion injury, sepsis, heart failure, viral myocarditis and cardiac allograft rejection. Although circulating TNFalpha and leptin levels ... | 10.1016/j.cyto.2005.09.010 | 16,298,137 | D000818:Animals; D002469:Cell Separation; D006352:Heart Ventricles; D066298:In Vitro Techniques; D020738:Leptin; D008297:Male; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha | Cytokine | 2,005 | D020738:Leptin; D014409:Tumor Necrosis Factor-alpha |
ProFit revisited. | PURPOSE
An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data.
METHODS
The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured... | 10.1002/mrm.24703 | 23,475,809 | D001923:Brain Chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D012984:Software; D012986:Software Validation | Magnetic resonance in medicine | 2,014 | |
Infrared and Raman spectroscopy study of Si1-xGexO2 solid solutions with α-quartz structures. | Single crystals of α-quartz-type Si1-xGexO2 (x < 0.12), grown under hydrothermal conditions in NH4F solutions, were investigated using infrared (IR) and Raman spectroscopy. Compositional dependencies of the IR absorption spectra were found both for the fundamental and combination vibrations. With an increase in Ge cont... | 10.1016/j.saa.2020.118168 | 32,151,985 | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | 2,020 | ||
Safety of smartwatches and their chargers in patients with cardiac implantable electronic devices. | AIMS
Cardiac implantable electronic devices (CIEDs) are susceptible to electromagnetic interference (EMI). Smartwatches and their chargers could be a possible source of EMI. We sought to assess whether the latest generation smartwatches and their chargers interfere with proper CIED function.
METHODS AND RESULTS
We in... | 10.1093/europace/euaa220 | 33,038,213 | D017147:Defibrillators, Implantable; D011211:Electric Power Supplies; D004574:Electromagnetic Fields; D004581:Electronics; D005260:Female; D006801:Humans; D060526:Magnetic Fields; D008297:Male; D010138:Pacemaker, Artificial | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | 2,021 | |
[Clinical characteristics and influencing factors of children with parent-reported food allergy]. | Objective: To analyze the clinical characteristics and influencing factors of children with parent-reported food allergy (FA), thus providing empirical evidence for facilitating the effective utilization of medical history information and promoting better health education for parents. Methods: A cross-sectional study w... | 10.3760/cma.j.cn112140-20211215-01047 | 35,768,355 | D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005512:Food Hypersensitivity; D006801:Humans; D008297:Male; D010290:Parents; D015995:Prevalence; D011795:Surveys and Questionnaires | Zhonghua er ke za zhi = Chinese journal of pediatrics | 2,022 | |
Mercury ions impact the kinetic and thermal stabilities of human lens γ-crystallins via direct metal-protein interactions. | Loss of metal homeostasis may be involved in several age-related diseases, such as cataracts. Cataracts are caused by the aggregation of lens proteins into light-scattering high molecular weight complexes that impair vision. Environmental exposure to heavy metals, such as mercury, is a risk factor for cataract developm... | 10.1016/j.jinorgbio.2023.112159 | 36,827,733 | D006801:Humans; D038222:gamma-Crystallins; D008628:Mercury; D002386:Cataract; D009154:Mutation; D007477:Ions | Journal of inorganic biochemistry | 2,023 | D038222:gamma-Crystallins; D008628:Mercury; D007477:Ions |
The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis. | OBJECTIVE
To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA).
METHODS
Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V beta 6.7), a... | 10.1002/art.1780380114 | 7,818,578 | D000293:Adolescent; D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006684:HLA-DR Antigens; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alph... | Arthritis and rheumatism | 1,995 | D005819:Genetic Markers; D006684:HLA-DR Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta |
The hazardous waste management system--Environmental Protection Agency. Interim final amendments to interim final and final rules. | The Resource Conservation and Recovery Act (RCRA) requires that EPA set regulatory standards for all facilities which treat, store, or dispose of hazardous waste. In partial implementation of its requirement, on January 23, 1981, EPA set regulatory standards for incinerators that burn hazardous waste. These regulations... | 10,255,871 | D012037:Refuse Disposal; D014481:United States; D014484:United States Environmental Protection Agency | Federal register | 1,982 | ||
Experts' Misinterpretation of Box Plots - a Dual Processing Approach. | Recent studies have shown that students often misinterpret the area of the box in box plots as representing the frequency or proportion of observations in that interval, while it actually represents density. This misinterpretation has been shown to be based on the saliency of this area and can be explained by heuristic... | 10.5334/pb.az | 30,479,411 | Psychologica Belgica | 2,014 | ||
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. | ADAs play a pivotal role in regulating the level of adenosine, a signaling molecule controlling a variety of cellular responses by binding to and activating four ADRs. Two enzymes, ADA1 and ADA2, are known to possess ADA activity in humans. Although the structure of ADA1 and its role in lymphocytic activation have been... | 10.1189/jlb.1109764 | 20,453,107 | D056704:Adaptive Immunity; D000243:Adenosine Deaminase; D002454:Cell Differentiation; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D007113:Immunity, Innate; D036341:Intercellular Signaling Peptides and Proteins; D008264:Macrophages; D009000:Monocytes; D006377:T-Lymphocytes, Helper-Inducer | Journal of leukocyte biology | 2,010 | D036341:Intercellular Signaling Peptides and Proteins; C408373:ADA2 protein, human; D000243:Adenosine Deaminase |
Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines. | Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6-diaminouracil derivatives and various carboxylic acids using the recently de... | 10.3389/fchem.2019.00056 | 30,834,241 | Frontiers in chemistry | 2,019 | ||
Rupture of the perivisceral aorta: atherosclerotic versus mycotic aneurysm. | Twelve patients with rupture of the perivisceral abdominal aorta were admitted to the UCLA Medical Center between 1984 and 1996. Six patients had atherosclerotic thoracoabdominal aneurysms (TAA) which ruptured in the visceral segment of the aorta. The remaining 6 patients proved to have ruptured mycotic aneurysm (MA). ... | 10.1007/s100169900057 | 9,236,987 | D000368:Aged; D000785:Aneurysm, Infected; D017544:Aortic Aneurysm, Abdominal; D017545:Aortic Aneurysm, Thoracic; D001019:Aortic Rupture; D001161:Arteriosclerosis; D001807:Blood Vessel Prosthesis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors... | Annals of vascular surgery | 1,997 | |
Variability of the lower limb symmetry index associated with the gait parameters in the overweight adult population with flatfoot: a case-control study. | Background: Adult acquired flatfoot is characterized by a medial arch collapse during monopodal support in the stance phase, developing eversion of the calcaneus and abduction of the forefoot linked to the hindfoot. The purpose of our research was to analyze the dynamic symmetry index in the lower limbs comparing patie... | 10.3389/fbioe.2023.1189309 | 37,388,764 | Frontiers in bioengineering and biotechnology | 2,023 | ||
Nutrigenomic studies on hilsa to evaluate flesh quality attributes and genes associated with fatty acid metabolism from the rivers Hooghly and Padma. | The Indian shad hilsa (Tenualosa ilisha), a commercially important food fish rich in oils, enjoys high consumer preference in the South Asian countries owing to its unique flavour and culinary properties. The present study was undertaken with the primary objective of determining the flesh quality attributes of hilsa in... | 10.1016/j.foodres.2017.10.017 | 29,389,608 | D000596:Amino Acids; D000818:Animals; D005227:Fatty Acids; D005399:Fishes; D005504:Food Analysis; D006801:Humans; D007194:India; D050356:Lipid Metabolism; D008297:Male; D008903:Minerals; D018482:Muscle, Skeletal; D054647:Nutrigenomics; D009753:Nutritive Value; D012333:RNA, Messenger; D045483:Rivers; D017747:Seafood; D0... | Food research international (Ottawa, Ont.) | 2,018 | D000596:Amino Acids; D005227:Fatty Acids; D008903:Minerals; D012333:RNA, Messenger |
Intermediate filaments as histologic markers: an overview. | Determination of the type of intermediate filaments (IFs) present in a cell or tissue can yield information about its origin. Thus cells can be grouped into six different classes, i.e. epithelial cells characterized by cytokeratins, most but not all neurones characterized by neurofilaments (NFs), glial cells characteri... | 10.1111/1523-1747.ep12540811 | 6,190,955 | D000818:Animals; D003599:Cytoskeleton; D005455:Fluorescent Antibody Technique; D006801:Humans; D007381:Intermediate Filament Proteins; D007633:Keratins; D008545:Melanoma; D012867:Skin; D013274:Stomach Neoplasms; D014746:Vimentin | The Journal of investigative dermatology | 1,983 | D007381:Intermediate Filament Proteins; D014746:Vimentin; D007633:Keratins |
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